CN1188161C - Medicines for treating cervical vertebra illness - Google Patents
Medicines for treating cervical vertebra illness Download PDFInfo
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- CN1188161C CN1188161C CNB02159080XA CN02159080A CN1188161C CN 1188161 C CN1188161 C CN 1188161C CN B02159080X A CNB02159080X A CN B02159080XA CN 02159080 A CN02159080 A CN 02159080A CN 1188161 C CN1188161 C CN 1188161C
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Abstract
The present invention discloses a Chinese medicine for treating cervical spondylosis, which is prepared from the following crude drugs: astragalus root, Chinese angelica, radix paeoniae alba, fleece-flower root, barbary wolfberry fruit, mistletoe, pilose antler, rhizoma drynariae, clematis root, garden balsam stem, moschus, pueraria root and hemlock parsley. The medicine can be prepared into different clinical dosage forms, the total effective rate for treating cervical spondylosis is 90.00%, and the effective healing rate is 46.67%.
Description
Technical field
The invention relates to the Chinese medicine of treatment cervical spondylosis, is to be according to composition of prescription with Traditional Chinese medical theory, and the medicine according to certain preparation process is prepared from belongs to the field of Chinese medicines.
Background technology
Cervical spondylosis is a kind of disease that causes because of cervical vertebra and surrounding tissue regression thereof, belongs to the category of cervical vertebra strain, is commonly encountered diseases clinically, frequently-occurring disease.Particularly common in the middle-aged and elderly people.Along with modern society's rhythm of life is accelerated, working method changes, and computer, air-conditioning are extensive use of, and people suffer the wind-cold damp pathogen invasion and attack and bend the neck probability to increase considerably, and cause the cervical spondylosis sickness rate constantly to rise, and age of onset constantly shift to an earlier date.In case suffer from this disease, often touching difficulty more not only influences the cervical region nerve root, blood vessel, spinal cord, dizziness appears, headache, neck aching pain in should and back, upper limb radiating pain, symptoms such as weakness of the lower extremities, and often feed through to histoorgans such as the heart, cerebrovascular, gastrointestinal tract, and can induce cerebrovascular accident, coronary heart disease etc.Scholarly forecast, to mid-term in this century, this disease will become a kind of modern disease that accompanies with modern society, and it is the status that the lumbago and skelalgia of main inducing rises to the clinical main disease of orthopedics department that cervical spondylosis will replace with the physical work.Therefore, the research of relevant cervical spondylosis is the important topic of modern medical service health care.Chinese medicine is one of important means of cervical spondylosis non-operative treatment, and in recent years, traditional Chinese massage, acupuncture and treatment by Chinese herbs cervical spondylosis all obtain better curative effect.But the pathologic basis of further investigation cervical spondylosis and control new technique are given full play to important channel and direction that the Chinese medicine advantage is still research at present and in the future.
Summary of the invention
Medicine of the present invention is according to the clinical empirical summary composition of prescription, and prescription is carried out pharmacology, pharmacodynamic study and clinical experimental study develops.
The raw material of preparation medicine of the present invention is formed by weight as follows:
Radix Astragali 400-800 weight portion Radix Angelicae Sinensis 150-350 weight portion Radix Paeoniae Alba 150-350 weight portion
Radix Polygoni Multiflori 150-350 weight portion Fructus Lycii 200-400 weight portion Herba Visci 100-250 weight portion
Cornu Cervi Pantotrichum 1-10 weight portion Rhizoma Drynariae 150-350 weight portion
The raw material of preparation medicine of the present invention also contains the component of following weight ratio:
Radix Clematidis 250-450 weight portion Herba speranskiae tuberculatae 150-350 weight portion Moschus 0.5-2 weight portion
Radix Puerariae 150-350 weight portion
The raw material of preparation medicine of the present invention further also contains Rhizoma Chuanxiong 150-350 weight portion.
The raw material preferred weight proportioning of preparation medicine of the present invention is:
Radix Astragali 500-700 weight portion Radix Angelicae Sinensis 200-300 weight portion Radix Paeoniae Alba 200-300 weight portion
Radix Polygoni Multiflori 200-300 weight portion Fructus Lycii 250-350 weight portion Herba Visci 150-200 weight portion
Cornu Cervi Pantotrichum 2-8 weight portion Rhizoma Drynariae 200-300 weight portion Radix Clematidis 300-400 weight portion
Herba speranskiae tuberculatae 200-300 weight portion Moschus 0.8-1.5 weight portion Radix Puerariae 200-300 weight portion
Rhizoma Chuanxiong 200-300 weight portion
The optimum weight proportioning of above-mentioned raw materials is:
The Radix Astragali 600 weight portion Radix Angelicae Sinensis 240 weight portion Radix Paeoniae Albas 240 weight portions
Radix Polygoni Multiflori Preparata 240 weight portion Fructus Lycii 320 weight portion Herba Viscis 160 weight portions
Cornu Cervi Pantotrichum 5 weight portion Rhizoma Drynariae 240 weight portion Radix Clematidis 320 weight portions
Herba speranskiae tuberculatae 240 weight portion Moschus 1 weight portion Radix Puerariae 240 weight portions
Rhizoma Chuanxiong 240 weight portions
Radix Polygoni Multiflori in the middle of said medicine is formed preferably uses Radix Polygoni Multiflori Preparata.
According to the preparation process of routine, above-mentioned raw materials can be prepared into clinical medicine dosage form commonly used, for example, pill, tablet, granule, oral liquid, capsule, unguentum, Emulsion, masticatory, injection etc.Can add conventional drug excipient in the middle of the said medicine preparation as required, for example flavoring agent, dispersant, binding agent, thickening agent, lubricant, diluent etc.
The preparation technology of medicine capsule of the present invention is as follows:
Choose raw material according to the above-mentioned raw materials proportioning, wherein Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder, and be standby.Herba Visci, Radix Puerariae, Rhizoma Chuanxiong add the ethanol extraction secondary, and each 1-2 hour, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; Eight flavors such as all the other Radixs Astragali decoct with water secondary, and amount of water is advisable not have powder, decocts 1-2 hour for the first time, decocts 0.5-1 hour for the second time, collecting decoction filters, and filtrate decompression concentrates, and adds ethanol, cold preservation (2～2 ℃) is spent the night or 24 hours, filters, and filtrate recycling ethanol concentrates.Merge above two kinds of thick pastes, add appropriate amount of starch (the starch addition can be according to the denseness adjustment of thick paste, and those of ordinary skill in the art can easily determine according to the record of textbook), mixing, drying is ground into fine powder, adds Cornu Cervi Pantotrichum, the Moschus fine powder, mixing sieves, and incapsulates, promptly.
Medicine of the present invention has vital energy benefiting and the kidney invigorating, and the effect of promoting blood circulation to remove obstruction in the collateral is used for cervical spondylosis (neck type, spondylotic radiculopathy), deficiency of the liver and kindey, syndrome of blood stasis due to qi deficiency.Disease is seen nuchal pain and heaviness, aching pain in should and back, and disease of hand, limbs wither soft unable, and be dizzy waits disease.And press " new Chinese medicine treatment cervical spondylosis clinical research guideline " and carry out clinical observation, the result shows, medicine capsule treatment cervical spondylosis deficiency of the liver and kindey of the present invention, neck pain, aching pain in should and back due to the syndrome of blood stasis due to qi deficiency, the limbs flaccidity is weak, disease of hand is unable, and Mental fatigue shape is tired, dizziness and headache, Hiccough and deaf, or instability of gait, the dyskinesia, light red tongue, thready pulse weak person has significant curative effect, total effective rate is 90.00%, and cure-remarkable-effectiveness rate is 46.67%.Medicine capsule of the present invention is improving aspect the symptom, improves evident in efficacyly just to clash into sign, learns by statistics and handles, and treats the forward and backward significant difference that relatively has.
The influence of experimental example 1 medicine xylol induced mice auricle edema of the present invention
(1) test material:
Medicine and reagent: neck relieving capsule (trade name of medicine of the present invention), specification: the 0.53g/ grain, every is equivalent to crude drug 3.086g, and the time spent is mixed with desired concn with distilled water, the unit of providing: Shandong bio-pharmaceutical institute, lot number: 20000623; JINGFUKANG KELI, specification: the 10g/ bag, Hebei province Chengde Traditional Chinese Medicine Group Co., Ltd produces, lot number: 20000613; Bacillus calmette-guerin vaccine, 10mg/ props up, Lanzhou Inst. of Biological Products, Ministry of Public Health, lot number: 950406; Lanoline, Shanghai reagent one factory, lot number: 91-01-01.
Animal: Kunming mouse, the Wistar rat provides by Shandong University's Experimental Animal Center, the quality certification number: Shandong kinoplaszm word 200001003.
Instrument: XZC-2B type autocontrol temperature hot-plate instrument, Shandong Academy of Medical Sciences maintenance of equipment supply station; 722 type spectrophotometers, Shanghai the 3rd analytical tool factory.
(2) method and result:
Get 50 of body weight 28-30g male mices, be divided into the heavy dose of group of neck relieving capsule (4.0g/kg) at random, dosage group (2.0g/kg) in the neck relieving capsule, neck relieving capsule small dose group (1.0g/kg), JINGFUKANG group (13.3g/kg) and blank group.Every day gastric infusion once, irritate the long-pending 0.5ml/20g of body of stomach, for three days on end, matched group is irritated the isopyknic distilled water of stomach.After the last administration 30ul dimethylbenzene is applied to two sides, mouse right ear exterior feature front and back and causes inflammation, left auricle in contrast.Cause scorching back 30 minutes mice is caused death, take off left and right auricle with diameter 9mm card punch at identical position, weigh, calculating left and right auricle weight difference is the swelling degree.The results are shown in Table 1.
The influence (n=10) of table 1 neck relieving capsule xylol induced mice auricle edema
Group dosage (g/kg) left and right sides auricle weight difference P value
(mg， X±SD)
Matched group-27.05 ± 6.50---
Neck relieving capsule 4.0 17.75 ± 7.66＜0.01
Neck relieving capsule 2.0 19.60 ± 6.92＜0.05
Neck relieving capsule 1.0 24.95 ± 6.61＞0.05
JINGFUKANG 13.3 19.90 ± 6.03＜0.05
The result shows that the big or middle dosage of neck relieving capsule can make mice auricle swelling obviously alleviate, and shows that this medicine has tangible antiinflammatory action.
The influence of rat toes swelling due to experimental example 2 on Carrageenan
(1) experiment material: with experimental example 1
(2) method and result: get 50 of healthy male rats, body weight 170-180g is divided into 5 groups at random, be respectively the heavy dose of group of neck relieving capsule (3.2g/kg), middle dosage group (1.6g/kg), small dose group (0.8g/kg), positive control JINGFUKANG group (10.0 fens g/kg) and distilled water matched group.Every day gastric infusion once, volume 2ml/200g, for three days on end, the blank group is irritated the isopyknic distilled water of stomach.Respectively organized the excellent metapedes of number after the last administration in 1 hour? subcutaneous injection 1% carrageenin 0.05ml causes inflammation, and mensuration causes before the inflammation and causes 1,2,3,4,5 hour the sufficient volume in scorching back respectively, and sufficient volume difference saw Table 2 as the swelling degree before and after calculating caused inflammation.
The influence of rat toes swelling due to the table 2. neck relieving capsule on Carrageenan (n=10, X ± SD)
Group dosage causes scorching back different time swelling degree (ml)
g/kg 1h 2h 3h 4h 5h
Matched group--0.80 ± 0.37 0.87 ± 0.26 0.86 ± 0.34 0.98 ± 0.26 1.11 ± 0.43
Neck relieving capsule 3.2 0.24 ± 0.23
*0.37 ± 0.23
*0.39 ± 0.27
*0.81 ± 0.32 0.96 ± 0.14
Neck relieving capsule 1.6 0.29 ± 0.24
*0.39 ± 0.24
*0.63 ± 0.37 0.81 ± 0.41 0.92 ± 0.28
Neck relieving capsule 0.8 0.73 ± 0.31 0.80 ± 0.39 0.92 ± 0.34 1.11 ± 0.32 1.13 ± 0.21
JINGFUKANG 10.0 0.45 ± 0.29
*0.55 ± 0.29
*0.92 ± 0.31 1.10 ± 0.38 0.98 ± 0.31
*P＜0.05,
*Compare with matched group P＜0.01
The result shows that the big or middle dosage group of neck relieving capsule has obvious inhibitory action causing the pedal swelling that scorching back 3 and 2 hours inner opposite angle forks dish glue causes respectively.
3 pairs of bullate influences of rat granuloma of experimental example
(1) experiment material: with experimental example 1.
(2) method and result:
Cotton balls is prepared: accurately take by weighing medical absorbent cotton 20mg and make cotton balls, every cotton balls adds green grass or young crops, each 0.1mg/0.2ml of streptomycin, dries standby for 50 ℃ behind the autoclaving.
Get 40 of male rats, body weight 170-180g uses the ether light anaesthesia, under the aseptic condition, and median incision of lower abdomen, the subcutaneous cotton balls of respectively inserting of each Mus bilateral groin.Postoperative is divided into 5 groups at random by body weight, is respectively the heavy dose of group of neck relieving capsule (3.2g/kg), middle dosage group (1.6g/kg), small dose group (0.8g/kg), positive control JINGFUKANG group (10.0g/kg) and distilled water matched group.Began to irritate stomach the same day in performing the operation, once a day, continuous 7 days, irritate the long-pending 2ml/200g of body of stomach, matched group is given the equal-volume distilled water, the 8th day execution animal, peel off cotton balls, 60 ℃ of bakings were weighed in 12 hours, calculated granulation weight (the cotton balls weight-cotton balls original weight of granulation weight=band granulation tissue).The results are shown in Table 3.
The influence (n=16) of table 3. pair rat granuloma hamartoplasia
Group dosage granulation tissue weight P value
(mg， X±SD)
Matched group--49.15 ± 7.86---
Neck relieving capsule 3.2 42.80 ± 8.80＜0.05
Neck relieving capsule 1.6 46.94 ± 6.57＞0.05
Neck relieving capsule 0.8 48.56 ± 6.98＞0.05
JINGFUKANG 10.0 43.19 ± 6.00＜0.05
The result shows that neck relieving capsule heavy dose can suppress rat granuloma hamartoplasia more significantly.Middle low dose of effect is not obvious.
Experimental example 4 analgesic activities
(1) experiment material: with experimental example 1.
(2) method and result:
Hot plate method: the Healthy female mice (body weight 20 ± 2g) 50 of preliminary election pain valve (55 ± 0.5 ℃ of hot plate temperatures) in 30 seconds, be divided into the heavy dose of group of neck relieving capsule (4.0g/kg) at random, dosage group (2.0g/kg) in the neck relieving capsule, JINGFUKANG group (13.3g/kg) and blank group.Every day gastric infusion once, volume 0.5ml/20g, for three days on end, the blank group is given isopyknic distilled water.With 1,2,3 hour pain threshold values after the administration of XZC-2B type autocontrol temperature hot-plate instrument survey mice.The results are shown in Table 4.
Table 4. pair mice hot plate causes the influence (n=10) of pain
Different time pain threshold values behind the group dosage medicine (s, X ± SD)
(g/kg) 1h 2h 3h
Matched group--22.60 ± 5.93 28.70 ± 7.69 25.30 ± 6.16
Neck relieving capsule 4.0 29.90 ± 11.57 39.00 ± 10.18
*32.50 ± 13.86
Neck relieving capsule 2.0 27.10 ± 6.57 39.00 ± 12.00
*31.90 ± 9.49
Neck relieving capsule 1.0 27.70 ± 10.25 26.20 ± 12.27 25.30 ± 7.80
JINGFUKANG 13.3 35.20 ± 14.53 40.50 ± 15.95
*29.60 ± 6.55
*Compare with matched group P＜0.05
The result shows that the big or middle dosage of neck relieving capsule can obviously improve the pain valve of mice in 2 hours after administration, shows that this medical instrument has good analgesic activity.
Writhing method: get 50 of 20 ± 2g mices, male and female half and half are divided into the heavy dose of group of neck relieving capsule (4.0g/kg), dosage group (2.0g/kg) in the neck relieving capsule, neck relieving capsule small dose group (1.0g/kg), JINGFUKANG group (13.3g/kg) and blank group at random.Every day gastric infusion once, for three days on end, irritate the long-pending 0.5ml/20g of body of stomach, matched group is given isopyknic distilled water.After the last administration 1.5 hours, the acetic acid 0.1ml/10g of lumbar injection 0.6%, record respectively organized and turn round the body number of times in the mice 15 minutes.See Table 5.
The influence of table 5. pair mouse writhing reaction (n=10, X ± SD)
Group dosage is turned round body number of times/15 minute P value
Blank group--25.50 ± 10.35---
Neck relieving capsule 4.0 16.20 ± 8.52＜0.05
Neck relieving capsule 2.0 22.90 ± 7.23＞0.05
Neck relieving capsule 1.0 23.10 ± 6.97＞0.05
JINGFUKANG 13.3 15.00 ± 8.86＜0.05
The result shows, the mice stomachache that the heavy dose of Dichlorodiphenyl Acetate of neck relieving capsule causes has significant analgesia role, in, low dose of effect is not obvious.
The influence of 5 pairs of mouse peritoneal capillary permeabilities of experimental example
(1) experiment material: with experimental example 1.
(2) method and result:
Get 50 of healthy male mices, body weight 20-22g is divided into the heavy dose of group of neck relieving capsule (4.0g/kg), dosage group (2.0g/kg) in the neck relieving capsule, neck relieving capsule small dose group (1.0g/kg), JINGFUKANG group (13.3g/kg) and blank group at random.Every day gastric infusion once, irritate the long-pending 0.1ml/20g of body of stomach, for three days on end, matched group is given isopyknic distilled water.After the last administration 1.5 hours, the azovan blue 0.1ml/10g of tail vein injection 0.5%, the glacial acetic acid 0.1ml/10g of lumbar injection 0.6% immediately, put to death mice after 15 minutes, with 5ml normal saline flushing abdominal cavity, with centrifugal 15 minutes of the flushing liquor 3000r that collects, get supernatant in 722 type spectrophotometer 590nm places survey shading value.The results are shown in Table 6.
The influence of table 6. pair mouse peritoneal capillary permeability (n=10, X ± SD)
Group dosage OD value P value
Blank group--0.478 ± 0.118--
Neck relieving capsule 4.0 0.269 ± 0.090＜0.01
Neck relieving capsule 2.0 0.335 ± 0.071＜0.01
Neck relieving capsule 1.0 0.405 ± 0.082＞0.05
JINGFUKANG 13.3 0.292 ± 0.072＜0.01
It is hyperfunction that the result shows that the big or middle dosage of neck relieving capsule can obviously reduce the mouse peritoneal capillary permeability that acetic acid causes, low dose of effect is not obvious.
The therapeutical effect of 6 pairs of rat assist agent arthritis primary affections of experimental example
(1) experiment material: with experimental example 1.
(2) method and result:
The preparation of Freund ' s Freund's complete adjuvant: warm abundant mixing with under 2: 1 in 70 ℃ of liquid paraffin and the lanolines, autoclaving, every milliliter adds bacillus calmette-guerin vaccine 10mg and fully grinds mixing then, and it is standby to make the Freund Freund's complete adjuvant.
Grouping and administration: 50 of male rats, body weight 180-200g is divided into 5 groups at random, is respectively the heavy dose of group of neck relieving capsule (3.2g/kg), middle dosage group (1.6g/kg), small dose group (0.8g/kg), positive control JINGFUKANG group (10.0g/kg) and matched group.Every day gastric infusion once, continuous 10 days, irritate the long-pending 2ml/200g of body of stomach, matched group is given isopyknic distilled water, after administration in the 7th day, respectively organize the right back toes intradermal injection of Mus Freund ' s Freund's complete adjuvant 0.1ml in 1.5 hours and cause inflammation, with rat foot volume determination instrument survey cause scorching before and cause scorching back 6 18 and respectively organized the right back sufficient volume of Mus in 72 hours, calculate cause scorching before and after sufficient volume difference be the swelling degree.Influence to the rat assist agent arthritis arthroncus sees Table 7.
The influence of table 7. pair adjuvant arthritis rats foot swelling (n=10, X ± SD)
Group dosage causes scorching front and back different time paw swelling (ml)
G/kg 6 hours 18 hours 72 hours
Matched group-1.54 ± 0.37 1.85 ± 0.36 2.57 ± 0.52
Neck relieving capsule 3.2 1.20 ± 0.33
*1.44 ± 0.46
*1.96 ± 0.57
*
Neck relieving capsule 1.6 1.38 ± 0.45 1.53 ± 0.52 2.10 ± 0.62
Neck relieving capsule 0.8 1.75 ± 0.20 1.77 ± 0.32 2.25 ± 0.46
JINGFUKANG 10.0 1.27 ± 0.33 1.51 ± 0.43 1.92 ± 0.57
*
*Compare with matched group P＜0.05
The result shows that foot swelling has the obvious suppression effect to neck relieving capsule heavy dose to adjuvant arthritis rats, in, low dose of do not have an obviously effect.
In sum, the rat toes swelling that mice auricle swelling that medicine xylol of the present invention causes and carrageenin cause has good inhibitory effect, it is hyperfunction to suppress glacial acetic acid induced mice abdominal cavity capillary permeability, rat granuloma hamartoplasia there is good inhibitory effect, the mice stomachache that the mice hot plate causes bitterly and acetic acid brings out is had analgesic activity preferably; Toes swelling to rat assist agent arthritis has therapeutical effect preferably.
Preferred forms
Embodiment 1
Radix Astragali 400g Radix Angelicae Sinensis 150g Radix Paeoniae Alba 150g
Radix Polygoni Multiflori 150g Fructus Lycii 200g Herba Visci 100g
Cornu Cervi Pantotrichum 1g Rhizoma Drynariae 150g Radix Clematidis 250g
Herba speranskiae tuberculatae 150g Moschus 0.5g Radix Puerariae 150g
Rhizoma Chuanxiong 150g
Choose raw material according to the above-mentioned raw materials proportioning, wherein Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder, and be standby.Herba Visci, Radix Puerariae, Rhizoma Chuanxiong add the ethanol extraction secondary, and each 1 hour, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; Eight flavors such as all the other Radixs Astragali decoct with water secondary, and amount of water is advisable not have powder, decocts 1 hour for the first time, decocts 0.5 hour for the second time, collecting decoction filters, and filtrate decompression concentrates, and adds ethanol, cold preservation (2～2 ℃) is spent the night, and filters, and filtrate recycling ethanol concentrates.Merge above two kinds of thick pastes, add appropriate amount of starch, mixing, drying is ground into fine powder, adds Cornu Cervi Pantotrichum, the Moschus fine powder, mixing sieves, and incapsulates, promptly.
Embodiment 2
Radix Astragali 800g Radix Angelicae Sinensis 350g Radix Paeoniae Alba 350g
Radix Polygoni Multiflori 350g Fructus Lycii 400g Herba Visci 250g
Cornu Cervi Pantotrichum 10g Rhizoma Drynariae 350g Radix Clematidis 450g
Herba speranskiae tuberculatae 350g Moschus 2g Radix Puerariae 350g
Rhizoma Chuanxiong 350g
Choose raw material according to the above-mentioned raw materials proportioning, wherein Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder, and be standby.Herba Visci, Radix Puerariae, Rhizoma Chuanxiong add 80% ethanol extraction secondary, and each 2 hours, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; Eight flavors such as all the other Radixs Astragali decoct with water secondary, and amount of water is advisable not have powder, decocts 2 hours for the first time, decocts 1 hour for the second time, collecting decoction filters, and filtrate decompression concentrates, and adds ethanol and makes and contain the alcohol amount and reach 80%, cold preservation (2～2 ℃) 24 hours filters, and filtrate recycling ethanol concentrates.Merge above two kinds of thick pastes, add appropriate amount of starch, mixing, drying is ground into fine powder, adds Cornu Cervi Pantotrichum, the Moschus fine powder, mixing sieves, and incapsulates, promptly.
Embodiment 3
Radix Astragali 500g Radix Angelicae Sinensis 200g Radix Paeoniae Alba 200g
Radix Polygoni Multiflori 200g Fructus Lycii 250g Herba Visci 150g
Cornu Cervi Pantotrichum 2g Rhizoma Drynariae 200g Radix Clematidis 300g
Herba speranskiae tuberculatae 200g Moschus 0.8g Radix Puerariae 200g
Rhizoma Chuanxiong 200g
Choose raw material according to the above-mentioned raw materials proportioning, wherein Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder, and be standby.Herba Visci, Radix Puerariae, Rhizoma Chuanxiong add the ethanol extraction secondary, and each 1 hour, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; Eight flavors such as all the other Radixs Astragali decoct with water secondary, and amount of water is advisable not have powder, decocts 1 hour for the first time, decocts 0.5 hour for the second time, collecting decoction filters, and filtrate decompression concentrates, and adds ethanol and makes and contain the alcohol amount and reach 70%, cold preservation (2～2 ℃) is spent the night, and filters, and filtrate recycling ethanol concentrates.Merge above two kinds of thick pastes, add appropriate amount of starch, mixing, drying is ground into fine powder, adds Cornu Cervi Pantotrichum, the Moschus fine powder, mixing sieves, and incapsulates, promptly.
Embodiment 4
Radix Astragali 700g Radix Angelicae Sinensis 300g Radix Paeoniae Alba 300g
Radix Polygoni Multiflori 300g Fructus Lycii 350g Herba Visci 200g
Cornu Cervi Pantotrichum 8g Rhizoma Drynariae 300g Radix Clematidis 400g
Herba speranskiae tuberculatae 300g Moschus 1.5g Radix Puerariae 300g
Rhizoma Chuanxiong 300g
Choose raw material according to the above-mentioned raw materials proportioning, wherein Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder, and be standby.Herba Visci, Radix Puerariae, Rhizoma Chuanxiong add the ethanol extraction secondary, and each 2 hours, merge extractive liquid, filtered, and it is 1.30～1.32 thick paste that filtrate recycling ethanol, concentrating under reduced pressure become relative density; Eight flavors such as all the other Radixs Astragali decoct with water secondary, and amount of water is advisable not have powder, decocted 2 hours for the first time, decocted 1 hour for the second time, collecting decoction filters, filtrate decompression concentrates, add ethanol and make, cold preservation (2～2 ℃) 24 hours filters, filtrate recycling ethanol, being condensed into relative density is the thick paste of 1.30～1.35 (60 ℃).Merge above two kinds of thick pastes, add appropriate amount of starch, mixing, drying is ground into fine powder, adds Cornu Cervi Pantotrichum, the Moschus fine powder, mixing sieves, and incapsulates, promptly.
Embodiment 5
Radix Astragali 600g Radix Angelicae Sinensis 240g Radix Paeoniae Alba 240g
Radix Polygoni Multiflori Preparata 240g Fructus Lycii 320g Herba Visci 160g
Cornu Cervi Pantotrichum 5g Rhizoma Drynariae 240g Radix Clematidis 320g
Herba speranskiae tuberculatae 240 Moschus 1g Radix Puerariae 240g
Rhizoma Chuanxiong 240g
More than 13 the flavor, Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder.Herba Visci, Radix Puerariae, Rhizoma Chuanxiong add 70% ethanol extraction secondary, and each 2 hours, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; All the other Radixs Astragali etc. eight flavor decocts with water secondary, and 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrate decompression concentrates, and adds ethanol and makes and contain the alcohol amount and reach 70%, and cold preservation (2～2 ℃) 24 hours filters, and filtrate recycling ethanol concentrates.Merge above two kinds of thick pastes, add appropriate amount of starch, mixing, drying is ground into fine powder, adds Cornu Cervi Pantotrichum, the Moschus fine powder, mixing sieves, and incapsulates, and makes 1000, promptly.
Embodiment 6
Radix Astragali 400g Radix Angelicae Sinensis 150g Radix Paeoniae Alba 150g
Radix Polygoni Multiflori 150g Fructus Lycii 200g Herba Visci 100g
Cornu Cervi Pantotrichum 1g Rhizoma Drynariae 150g
Above medicine, Pulveratum Cornu Cervi Pantotrichum is broken into fine powder.Herba Visci adds 70% ethanol extraction secondary, and each 2 hours, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; All the other medicines decoct with water secondary, and 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrate decompression concentrates, and add ethanol and make and contain the alcohol amount and reach 70%, and cold preservation (2～2 ℃) 24 hours filters, and filtrate recycling ethanol concentrates.Merge above two kinds of thick pastes, add appropriate amount of starch, mixing, drying is ground into fine powder, adds velvet powder, and mixing sieves, and incapsulates, and makes 1000, promptly.
Embodiment 7
Radix Astragali 800g Radix Angelicae Sinensis 350g Radix Paeoniae Alba 350g
Radix Polygoni Multiflori 350g Fructus Lycii 400g Herba Visci 100g
Cornu Cervi Pantotrichum 10g Rhizoma Drynariae 350g
Above medicine, Pulveratum Cornu Cervi Pantotrichum is broken into fine powder.Herba Visci adds 70% ethanol extraction secondary, and each 2 hours, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; All the other medicines decoct with water secondary, and 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrate decompression concentrates, and add ethanol and make and contain the alcohol amount and reach 70%, and cold preservation (2～2 ℃) 24 hours filters, and filtrate recycling ethanol concentrates.Merge above two kinds of thick pastes, add appropriate amount of starch, mixing, drying is ground into fine powder, adds velvet powder, and mixing sieves, and incapsulates, and makes 1000, promptly.
Embodiment 8
Radix Astragali 400g Radix Angelicae Sinensis 150g Radix Paeoniae Alba 150g
Radix Polygoni Multiflori 150g Fructus Lycii 200g Herba Visci 100g
Cornu Cervi Pantotrichum 1g Rhizoma Drynariae 150g Radix Clematidis 250g
Herba speranskiae tuberculatae 150g Moschus 0.5g Radix Puerariae 150g
Above medicine, Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder.Herba Visci, Radix Puerariae add 70% ethanol extraction secondary, and each 2 hours, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; All the other medicines decoct with water secondary, and 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrate decompression concentrates, and add ethanol and make and contain the alcohol amount and reach 70%, and cold preservation (2～2 ℃) 24 hours filters, and filtrate recycling ethanol concentrates.Merge above two kinds of thick pastes, add appropriate amount of starch, mixing, drying is ground into fine powder, adds Cornu Cervi Pantotrichum, the Moschus fine powder, mixing sieves, and incapsulates, and makes 1000, promptly.
Embodiment 9
Radix Astragali 800g Radix Angelicae Sinensis 350g Radix Paeoniae Alba 350g
Radix Polygoni Multiflori 350g Fructus Lycii 400g Herba Visci 250g
Cornu Cervi Pantotrichum 10g Rhizoma Drynariae 350g Radix Clematidis 450g
Herba speranskiae tuberculatae 350g Moschus 2g Radix Puerariae 350g
Above medicine, Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder.Herba Visci, Radix Puerariae add 70% ethanol extraction secondary, and each 2 hours, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; All the other medicines decoct with water secondary, and 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrate decompression concentrates, and add ethanol and make and contain the alcohol amount and reach 70%, and cold preservation (2～2 ℃) 24 hours filters, and filtrate recycling ethanol concentrates.Merge above two kinds of thick pastes, add appropriate amount of starch, mixing, drying is ground into fine powder, adds Cornu Cervi Pantotrichum, the Moschus fine powder, mixing sieves, and incapsulates, and makes 1000, promptly.
Claims (10)
1, a kind of medicine for the treatment of cervical spondylosis is characterised in that its effective ingredient mainly is to be made by the raw material of following weight portion:
Radix Astragali 400-800 weight portion Radix Angelicae Sinensis 150-350 weight portion
Radix Paeoniae Alba 150-350 weight portion Radix Polygoni Multiflori 150-350 weight portion
Fructus Lycii 200-400 weight portion Herba Visci 100-250 weight portion
Cornu Cervi Pantotrichum 1-10 weight portion Rhizoma Drynariae 150-350 weight portion.
2, medicine according to claim 1 is characterized in that also having in the raw material:
Radix Clematidis 250-450 weight portion Herba speranskiae tuberculatae 150-350 weight portion
Moschus 0.5-2 weight portion Radix Puerariae 150-350 weight portion.
3, medicine according to claim 2 is characterized in that also containing in the raw material Rhizoma Chuanxiong 150-350 weight portion.
4, medicine according to claim 3 is characterized in that said raw material weight ratio is:
Radix Astragali 500-700 weight portion Radix Angelicae Sinensis 200-300 weight portion
Radix Paeoniae Alba 200-300 weight portion Radix Polygoni Multiflori 200-300 weight portion
Fructus Lycii 250-350 weight portion Herba Visci 150-200 weight portion
Cornu Cervi Pantotrichum 2-8 weight portion Rhizoma Drynariae 200-300 weight portion
Radix Clematidis 300-400 weight portion Herba speranskiae tuberculatae 200-300 weight portion
Moschus 0.8-1.5 weight portion Radix Puerariae 200-300 weight portion
Rhizoma Chuanxiong 200-300 weight portion.
5, medicine according to claim 4 is characterized in that said raw material weight ratio is
The Radix Astragali 600 weight portion Radix Angelicae Sinensis 240 weight portions
The Radix Paeoniae Alba 240 weight portion Radix Polygoni Multiflori Preparatas 240 weight portions
Fructus Lycii 320 weight portion Herba Viscis 160 weight portions
Cornu Cervi Pantotrichum 5 weight portion Rhizoma Drynariae 240 weight portions
Radix Clematidis 320 weight portion Herba speranskiae tuberculataes 240 weight portions
Moschus 1 weight portion Radix Puerariae 240 weight portions
Rhizoma Chuanxiong 240 weight portions.
6, medicine according to claim 5, it is characterized in that it prepares according to following method: Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder, and Herba Visci, Radix Puerariae, Rhizoma Chuanxiong add the ethanol extraction secondary, each 1-2 hour, merge extractive liquid, filtered, filtrate recycling ethanol, concentrating under reduced pressure; All the other eight flavors decoct with water secondary, decoct 1-2 hour for the first time, decoct 0.5-1 hour for the second time, collecting decoction filters, and filtrate decompression concentrates, and adds ethanol,-2～2 ℃ of cold preservations are spent the night or 24 hours, filter, and filtrate recycling ethanol concentrates, merge above two kinds of thick pastes, add starch, mixing, drying, be ground into fine powder, add Cornu Cervi Pantotrichum, the Moschus fine powder, mixing sieves, and incapsulates.
7,, it is characterized in that it prepares according to following method according to the medicine of claim 6:
Cornu Cervi Pantotrichum, Moschus powder are broken into fine powder, and Herba Visci, Radix Puerariae, Rhizoma Chuanxiong add the ethanol extraction secondary, and each 2 hours, merge extractive liquid, filtered filtrate recycling ethanol, concentrating under reduced pressure; All the other eight flavors decoct with water secondary, and 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and filtrate decompression concentrates, and adds ethanol,-2～2 ℃ of cold preservation 24 hours filters, and filtrate recycling ethanol is condensed into relative density and is 1.30～1.35 thick paste, merge above two kinds of thick pastes, add starch, mixing, drying, be ground into fine powder, add Cornu Cervi Pantotrichum, Moschus fine powder, mixing, sieve, incapsulate, make 1000.
8,, it is characterized in that its dosage form is any in the middle of pill, tablet, granule, oral liquid, capsule, unguentum, Emulsion, masticatory and the injection according to any medicine among the claim 1-5.
9, according to said any medicine of claim 1-5, it is characterized in that wherein having added drug excipient.
10,, it is characterized in that said excipient is one or more in the middle of flavoring agent, dispersant, binding agent, thickening agent, lubricant and the diluent according to the said medicine of claim 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02159080XA CN1188161C (en) | 2002-12-31 | 2002-12-31 | Medicines for treating cervical vertebra illness |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02159080XA CN1188161C (en) | 2002-12-31 | 2002-12-31 | Medicines for treating cervical vertebra illness |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1424097A CN1424097A (en) | 2003-06-18 |
| CN1188161C true CN1188161C (en) | 2005-02-09 |
Family
ID=4753233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB02159080XA Expired - Lifetime CN1188161C (en) | 2002-12-31 | 2002-12-31 | Medicines for treating cervical vertebra illness |
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| Country | Link |
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| CN (1) | CN1188161C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394068B (en) * | 2013-08-20 | 2015-04-01 | 李运峰 | Drug for curing acute attack of cervical spondylotic radiculopathy |
| CN111467411A (en) * | 2020-04-20 | 2020-07-31 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for preventing and treating diabetic complications and preparation method and application thereof |
| CN111317769A (en) * | 2020-04-20 | 2020-06-23 | 鲁南制药集团股份有限公司 | Application of traditional Chinese medicine composition in treatment of postoperative complications of arthroscopic surgery |
| CN111544492A (en) * | 2020-06-24 | 2020-08-18 | 鲁南厚普制药有限公司 | Application of radix Angelicae sinensis and radix astragali blood circulation promoting preparation in preparing medicine for treating eyeground vascular diseases and preparation method thereof |
| CN113181297A (en) * | 2021-03-20 | 2021-07-30 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for treating cervical spondylosis and preparation method thereof |
| CN115192654B (en) * | 2021-04-09 | 2023-06-06 | 山东新时代药业有限公司 | New medical application of radix angelicae sinensis blood-activating preparation |
| CN115607607A (en) * | 2021-07-14 | 2023-01-17 | 鲁南制药集团股份有限公司 | Application of radix angelicae sinensis and astragalus membranaceus blood activating preparation in preparation of medicines for treating dysmenorrhea and preparation method of preparation |
-
2002
- 2002-12-31 CN CNB02159080XA patent/CN1188161C/en not_active Expired - Lifetime
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| Publication number | Publication date |
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| CN1424097A (en) | 2003-06-18 |
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Assignee: LUNAN HOPE PHARMACEUTICAL Co.,Ltd. Assignor: LUNAN PHARMACEUTICAL Group Corp. Contract record no.: 2010370000515 Denomination of invention: Medicament for treating cervical spondylosis Granted publication date: 20050209 License type: Exclusive License Open date: 20030618 Record date: 20100909 |
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