CN117599012A - Preparation method of nose comfort tablet - Google Patents

Abstract

The invention provides a preparation method of a nose comfort tablet, which comprises the following steps: mixing fructus Xanthii, flos Chrysanthemi Indici, herba Centipedae, radix Angelicae Dahuricae, radix Saposhnikoviae, herba Ecliptae, radix Paeoniae alba, glycyrrhrizae radix and fructus Tribuli, pulverizing, micronizing to obtain second powder, mixing with water, extracting in a microwave and ultrasonic synergistic extraction tank, filtering, and concentrating to obtain soft extract; adding Arisaema cum bile fine powder and medicinal starch, granulating, drying, adding chlorpheniramine maleate, magnesium stearate, oleum herba Pogostemonis, and oleum Menthae Dementholatum, tabletting, and sugar coating. The preparation method adopts superfine grinding to treat the raw materials, and combines microwave-ultrasonic synergistic extraction to facilitate the full dissolution of active ingredients, avoid the damage of high temperature to the active ingredients, and the prepared nasal comfort tablet has high curative effect. Moreover, the method is simple to operate, is suitable for quality control, is convenient for industrial production, and has good application prospect.

Description

Preparation method of nasal comfort tablets

Technical field

The invention belongs to the field of medical technology, and specifically relates to a preparation method of nasal comfort tablets.

Background technique

According to reports, one in six people worldwide suffers from various rhinitis, and the incidence of rhinitis in China is much higher than this figure. Rhinitis is a common disease. Rhinitis is an inflammatory disease of the nasal cavity. It is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. The main pathological changes of rhinitis are nasal mucosal congestion, Swelling, exudation, hyperplasia, atrophy or necrosis, etc. Especially today, when environmental pollution is becoming more and more serious and there are more and more unpredictable and extreme weather conditions, there are more and more rhinitis patients, and they tend to be younger, and rhinitis seems to be minor. The disease is actually very harmful. It greatly affects the five senses of the human body during the onset period and brings great pain to the work and life of rhinitis patients. If it is not effectively treated for a long time, it will induce a variety of serious diseases and even be life-threatening. .

The Nasal Comfort Tablets are collected in the seventh volume of the Ministry of Health’s Drug Standards for Traditional Chinese Medicine Preparations. It is made from Xanthium sibiricum, wild chrysanthemum, gooseberry, angelica dahurica, sapsroot, moxa lotus, white peony root, binanxing, licorice, tribulus terrestris and chlorpheniramine maleate as raw materials. Nose Comfort Tablets have the effects of clearing away heat, reducing inflammation, and clearing the orifice. It is used to treat sneezing, runny nose, nasal congestion, headache caused by chronic rhinitis, allergic rhinitis, and chronic sinusitis. It is easy to use and has extremely broad market sales prospects.

However, there are currently many production processes for nasal comfort tablets, resulting in uneven quality of nasal comfort tablets. In addition, the use of traditional processes to prepare nasal comfort tablets has shortcomings such as low efficacy. Therefore, it is necessary to improve the preparation method of nasal comfort tablets.

Contents of the invention

In view of the shortcomings of the existing technology, the technical problem to be solved by the present invention is to provide a preparation method for nasal comfort tablets. This method uses ultrafine pulverization to process the raw materials, combined with microwave-ultrasonic collaborative extraction, which is conducive to the full dissolution of the active ingredients, and The destruction of active ingredients by high temperature is avoided, and the prepared nasal comfort tablets have high curative effect.

In order to achieve the purpose of the present invention, the present invention adopts the following technical solutions:

The invention provides a method for preparing nasal comfort tablets, which method includes:

(1) Weigh 364g of Xanthium sibiricum, 145g of wild chrysanthemum, 218g of Herbivorous Goose, 109g of Angelica dahurica, 109g of Fangfeng, 218g of Asparagus chinensis, 145g of white peony root, 70g of Dannanxing, 73g of licorice, 218g of Tribulus terrestris, and chlorobenzene maleate. Namin 0.3g, spare;

(2) Crush the Dananxing weighed in step (1) and pass it through a 80-100 mesh sieve to obtain Dananxing fine powder;

(3) Mix the Xanthium angustifolia, wild chrysanthemum, geese, angelica dahurica, sapsroot, moxa lotus, white peony root, licorice, and tribulus terrestris weighed in step (1), and then use a grinder to crush them for 1h-2h to obtain the first A powder, and then grind the first powder in an ultrafine pulverizer for 0.5-1h to prepare a second powder;

(4) Add water to the second powder prepared in step (3) to mix, and then add microwave and ultrasonic waves to a cooperative extraction tank for extraction. The extract is filtered and concentrated to obtain a thick paste;

(5) Add the binanxin fine powder from step (2) to the thick paste prepared in step (4), and then add an appropriate amount of auxiliary medicinal starch, mix well, and make granules. After drying, add the powder from step (1) and weigh Mix chlorpheniramine maleate with an appropriate amount of magnesium stearate, patchouli oil, and peppermint oil, press into tablets, and coat with sugar to obtain nasal comfort tablets.

Preferably, in step (4):

The volume ratio of the second powder to water is 1:4-6.

The ultrasonic frequency is 30-40KHz and the power is 0.8-1KW; the microwave frequency is 1500-1600MHz and the power is 2-2.5KW; the collaborative extraction temperature is 55-65°C and the extraction time is 1.5-2.5h.

The concentration uses a vacuum concentration tank. During the concentration process, the vacuum degree is controlled to 0.04-0.06Mpa.

Preferably, in step (5):

Add the Dannanxing fine powder from step (2) to the thick paste prepared in step (4), then add an appropriate amount of auxiliary medicinal starch, mix in a trough mixer, and then put it into a swing granulator to pass through a 12-mesh sieve. Wet the granules, and then put them into a one-step granulator to dry for 30 to 45 minutes. Control the temperature at 50 to 60°C to control the moisture content of the granules within 5%. Stop drying, pour out, and put them into a swing granulator to pass through a 14-mesh sieve. Granules, and finally put the prepared granules into the mixing equipment, add the chlorpheniramine maleate weighed in step (1) and an appropriate amount of magnesium stearate, patchouli oil, and peppermint oil, mix well, press into tablets, and wrap Sugar coating, you get nasal comfort tablets.

Compared with the existing technology, the present invention has the following beneficial effects:

The invention provides a method for preparing nasal comfort tablets. The method uses ultrafine pulverization to process the raw materials, and then combines microwave-ultrasonic collaborative extraction, which is beneficial to the full dissolution of the active ingredients and avoids damage to the active ingredients at high temperatures. The preparation method The nasal comfort tablets have high efficacy, which can reduce the amount of oral medication and reduce the side effects of oral medications on the human liver. Moreover, this method is simple to operate, suitable for quality control, convenient for industrial production, and has good application prospects.

Detailed ways

The embodiments of the present invention are described in detail below. The examples are given to better illustrate the content of the present invention. They are only used to explain the present invention and cannot be understood as limiting the present invention.

If specific techniques or conditions are not specified in the examples, the techniques or conditions described in literature in the field shall be followed, or the product instructions shall be followed. If the manufacturer of the reagents or instruments used is not indicated, they are all conventional products that can be purchased through regular channels.

Example 1: Preparation method of nasal comfort tablets, including:

(1) Weigh 364g of Xanthium sibiricum, 145g of wild chrysanthemum, 218g of Herbivorous Goose, 109g of Angelica dahurica, 109g of Fangfeng, 218g of Asparagus chinensis, 145g of white peony root, 70g of Dannanxing, 73g of licorice, 218g of Tribulus terrestris, and chlorobenzene maleate. Namin 0.3g;

(2) Crush the Dananxing weighed in step (1) and pass it through an 80-mesh sieve to obtain Dananxing fine powder;

(3) Mix the Xanthium angustifolia, wild chrysanthemum, geese, angelica dahurica, saspermum, moxibustion root, white peony root, licorice, and tribulus terrestris weighed in step (1), and then use a grinder to crush it for 1 hour to obtain the first powder body, and then pulverize the first powder in an ultrafine pulverizer for 0.5h to obtain a second powder;

(4) Add 4 times the volume of water to the second powder prepared in step (3), stir and mix, and then add microwave and ultrasonic waves to a cooperative extraction tank for extraction. The ultrasonic frequency is 30KHz and the power is 0.8KW; microwave The frequency is 1500MHz, the power is 2KW; the collaborative extraction temperature is 55°C, and the extraction time is 1.5h; the obtained extract is filtered, and the filtrate is concentrated using a vacuum concentration tank. The vacuum degree is controlled to 0.04Mpa, and the extract is concentrated to a density of 1.30~1.35 When, a thick paste is made;

(5) Add the Dannanxing fine powder from step (2) to the thick paste prepared in step (4), then add an appropriate amount of auxiliary medicinal starch, mix in a trough mixer, and then put it into a swing granulator to pass Make wet granules through a 12-mesh sieve, and then put them into a one-step granulator to dry for 30 minutes. Control the temperature at 50°C to control the moisture content of the granules within 5%. Stop drying, pour out, and put them into a swing granulator through a 14-mesh sieve for granulation. , finally put the prepared granules into the general mixing equipment, add the chlorpheniramine maleate weighed in step (1) and an appropriate amount of magnesium stearate, 0.5ml patchouli oil, 0.5ml peppermint oil, mix well, and press Tablets, sugar-coated, to obtain 1,000 nasal comfort tablets (0.2g each).

Example 2: Preparation method of nasal comfort tablets, including:

(1) Weigh 364g of Xanthium sibiricum, 145g of wild chrysanthemum, 218g of Herbivorous Goose, 109g of Angelica dahurica, 109g of Fangfeng, 218g of Asparagus chinensis, 145g of white peony root, 70g of Dannanxing, 73g of licorice, 218g of Tribulus terrestris, and chlorobenzene maleate. Namin 0.3g;

(2) Crush the Dananxing weighed in step (1) and pass it through a 100-mesh sieve to obtain Dananxing fine powder;

(3) Mix the Xanthium angustifolia, wild chrysanthemum, geese, angelica dahurica, sapsroot, moxa lotus, white peony root, licorice, and tribulus terrestris weighed in step (1), and then grind them with a grinder for 2 hours to obtain the first powder. body, and then pulverize the first powder in an ultrafine pulverizer for 1 hour to obtain a second powder;

(4) Add 4 times the volume of water to the second powder prepared in step (3), stir and mix, and then add microwave and ultrasonic waves to a collaborative extraction tank for extraction. The ultrasonic frequency is 40KHz and the power is 1KW; The microwave frequency is 1600MHz, the power is 2.5KW; the collaborative extraction temperature is 65°C, and the extraction time is 2.5h; the obtained extract is filtered, and the filtrate is concentrated using a vacuum concentration tank. The vacuum degree is controlled to 0.06Mpa, and the extract is concentrated to When the density is 1.30~1.35, a thick paste is produced;

(5) Add the Dannanxing fine powder from step (2) to the thick paste prepared in step (4), then add an appropriate amount of auxiliary medicinal starch, mix in a trough mixer, and then put it into a swing granulator to pass Make wet granules through a 12-mesh sieve, and then put them into a one-step granulator to dry for 45 minutes. Control the temperature at 60°C so that the moisture content of the granules is within 5%. Stop drying, pour out, and put them into a swing granulator through a 14-mesh sieve for granulation. , finally put the prepared granules into the general mixing equipment, add the chlorpheniramine maleate weighed in step (1) and an appropriate amount of magnesium stearate, 0.5ml patchouli oil, 0.5ml peppermint oil, mix well, and press Tablets, sugar-coated, to obtain 1,000 nasal comfort tablets (0.2g each).

clinical experiments

1. Traditional Chinese Medicine Diagnostic Standards

Refer to the Traditional Chinese Medicine Industry Standard of the People's Republic of China "Standards for the Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes" issued by the State Administration of Traditional Chinese Medicine.

2. Research objects

This experimental case selected 90 patients with chronic rhinitis who were 20-60 years old and met the diagnostic criteria and visited the otolaryngology clinic, and were randomly divided into 3 groups.

3. Research methods

Treatment group 1: Oral administration of the Nashin Comfort Tablets prepared in Example 1, 3 times a day, 4 tablets at a time, 7 days as a course of treatment, and continuous administration of 2 courses of treatment.

Treatment group 2: Oral administration of the Nashin Comfort Tablets prepared in Example 2, 3 times a day, 4 tablets at a time, 7 days as one course of treatment, and 2 consecutive courses of treatment.

Control group: Take commercially available Xinfeng Pharmaceutical Nasal Comfort Tablets orally, 3 times a day, 4 tablets at a time, 7 days as a course of treatment, and take 2 consecutive courses of treatment.

No other therapeutic drugs and methods will be used during the entire treatment process, and observations and evaluations will be conducted on the 1st, 7th, 9th, 12th, and 14th days of treatment. The results are shown in Table 1.

Observe symptoms: sneezing, runny nose, nasal congestion, headache, turbinate swelling, mucosal and nasal secretions, tongue and pulse conditions.

Clinical efficacy evaluation standards

(1) Cure: Symptoms such as sneezing, nasal congestion, runny nose, headache, etc. disappear, nasal examination is normal, and the score is 0.

(2) Markedly effective: the main symptoms and signs are significantly improved (50-70%), and the points are reduced by 2/3.

(3) Effective: Symptoms such as sneezing, nasal congestion, runny nose, headache, etc. are alleviated, local physical signs are significantly improved, and the points are reduced by 1/3.

(4) Invalid: There is no significant improvement in symptoms and signs, and no change in points.

Table 1: Therapeutic effects of Nashu Comfort Tablets

As can be seen from Table 1, the nasal comfort tablets prepared by the preparation method of the present invention have obvious therapeutic effects on chronic rhinitis, and their therapeutic effects are significantly higher than those of the currently commercially available nasal comfort tablets. Moreover, the preparation method of the present invention is simple to operate, suitable for quality control, convenient for industrial production, and has good application prospects.

Obviously, the above-mentioned embodiments are only examples to clearly illustrate the present invention, but are not intended to limit the implementation of the present invention. Various changes and modifications can be made to the present invention by those skilled in the art without departing from the spirit and scope of the invention. In this way, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and equivalent technologies, the present invention is also intended to include these modifications and variations.

Claims (5)

1. A method of preparing a nasal comfort tablet, the method comprising:

(1) Weighing 364g of fructus xanthil, 145g of wild chrysanthemum, 218g of centipeda minima, 109g of angelica dahurica, 109g of radix sileris, 218g of eclipta alba, 145g of white peony root, 70g of arisaema cum bile, 73g of liquorice, 218g of caltrop and 0.3g of chlorpheniramine maleate for later use;

(2) Crushing the arisaema cum bile weighed in the step (1), and sieving the crushed arisaema cum bile by a 80-100-mesh sieve to obtain arisaema cum bile fine powder;

(3) Mixing the cocklebur fruit, the wild chrysanthemum flower, the centipeda minima, the angelica dahurica, the radix sileris, the eclipta alba, the liquorice and the caltrop which are weighed in the step (1), crushing for 1-2 hours by adopting a crusher to obtain first powder, and then putting the first powder into an ultrafine crusher to crush for 0.5-1 hour to obtain second powder;

(4) Adding water into the second powder prepared in the step (3) for mixing, then adding the mixture into a microwave and ultrasonic synergistic extraction tank for extraction, and filtering and concentrating the extract to obtain thick paste;

(5) Adding the arisaema cum bile fine powder obtained in the step (4) into the thick paste obtained in the step (2), adding a proper amount of auxiliary material medical starch, uniformly mixing, granulating, drying, adding chlorpheniramine maleate and a proper amount of magnesium stearate, patchouli oil and peppermint oil which are weighed in the step (1), uniformly mixing, tabletting, and coating with sugar to obtain the nasal comfort tablet.

2. The method according to claim 1, wherein in the step (4), the volume ratio of the second powder to water is 1:4-6.

3. The method according to claim 1, wherein in the step (4), the ultrasonic frequency is 30-40KHz and the power is 0.8-1KW; the microwave frequency is 1500-1600MHz, and the power is 2-2.5KW; the synergistic extraction temperature is 55-65 ℃; the extraction time is 1.5-2.5h.

4. The method according to claim 1, wherein in the step (4), the concentration is performed in a vacuum concentration tank, and the vacuum degree is controlled to be 0.04-0.06 Mpa during the concentration.

5. The preparation method of claim 1, wherein in the step (5), the arisaema cum bile fine powder of the step (2) is added into the thick paste prepared in the step (4), then a proper amount of auxiliary material medical starch is added, the mixture is uniformly mixed in a groove type mixer, then the mixture is put into a swing type granulator to be wet through a 12-mesh sieve, the mixture is put into a one-step granulator to be dried for 30 to 45 minutes, the temperature is controlled to be 50 to 60 ℃ to ensure that the water content of the particles is controlled to be within 5 percent, the mixture is stopped to be dried, poured out, put into a swing type granulator to be sieved through a 14-mesh sieve for finishing, and finally the prepared particles are put into a total mixing device, and then the chlorpheniramine maleate weighed in the step (1) and a proper amount of magnesium stearate, the sesame oil and the peppermint oil are added, uniformly mixed, pressed into tablets and sugar-coated to obtain the nose comfort tablet.