CN117537199A

CN117537199A - Connecting rod multistage locking sterile connection device, butt joint device, system and connection method

Info

Publication number: CN117537199A
Application number: CN202311282831.8A
Authority: CN
Inventors: 俞晓琳; 王峰; 李澳东; 潘建
Original assignee: Joymed Technology (shanghai) Ltd
Current assignee: Joymed Technology (shanghai) Ltd
Priority date: 2023-09-28
Filing date: 2023-09-28
Publication date: 2024-02-09

Abstract

The invention discloses a connecting rod multi-stage locking sterile connection device, a docking device, a system and a connection method, and relates to the technical field of sterile connectors. The key points of the technical solution include a main body, a connecting rod, a locking member, an isolation film and Sealing ring; the main body is provided with a pipe head, and the sealing ring is connected with the pipe head in the main body; the isolation film covers the side of the sealing ring away from the pipe head; the connecting rod is hinged with the main body; the main body is provided with a friction wall, the connecting rod and the friction wall They are arranged symmetrically on both sides of the pipe head axis; the locking member is connected to the connecting rod, and the locking member is used to apply pressure of different sizes to the resistance wall, and part or all of this pressure is used to convert into axial extrusion of the sealing ring. pressure. The construction of the sterile fluid passage in the present invention is achieved by applying axial extrusion forces of different sizes to the sealing rings, which effectively reduces the possibility of displacement of the two sealing rings when the isolation film is withdrawn, ensuring the reliability of the sterile fluid passage. .

Description

Connecting rod multistage locking sterile connection device, butt joint device, system and connection method

Technical Field

The invention relates to the technical field of aseptic connectors, in particular to a connecting rod multistage locking aseptic connecting device, a butt joint device, a system and a connecting method.

Background

In the fields of biology, medicine, etc., it is often necessary to connect different containers together under aseptic conditions to construct a sterile fluid pathway. In the prior art, aseptic connectors are often used to connect two containers.

A sterile coupling connector as disclosed in chinese patent CN216201461U, comprising a connector body and a barrier film; a limiting groove is formed in one end of the connector main body, and the axial lead of the limiting groove and the axial lead of the connector main body are on the same straight line; a connecting piece is arranged in the limiting groove, and the connecting piece is connected with the limiting groove in a clamping way; the connector comprises a connector main body, wherein a dustproof protection cover is arranged on the connector main body, and two clamping pieces with different lengths are respectively arranged at two ends of the dustproof protection cover; the clamping pieces are respectively connected with the clamping blocks in a clamping way, and the clamping blocks are respectively arranged on the outer surface of the connector main body; the isolating film covers the connecting piece and is welded with the surface of the connector main body, and one end of the isolating film is of a laminated structure and is welded on the upper surface of the dustproof protective cover.

In the patent, the two aseptic coupling connectors are fastened at one time through the fastening structure, and the isolation films on the two aseptic coupling connectors are pulled apart after fastening, so that the aseptic fluid passage can be opened. In order to ensure the tightness between the two aseptic coupling connectors after the isolating membrane is extracted, the connecting pieces in the two aseptic coupling connectors after being buckled can apply larger pressure to the isolating membrane so as to ensure that the two connecting pieces can tightly abut after the isolating membrane is extracted. The pressure can cause excessive friction between the isolating membrane and the connecting pieces, when the isolating membrane is pulled away, the two connecting pieces are easy to displace, the tightness of the sterile fluid passage is affected, and the reliability of the sterile coupling connector is deteriorated.

For the above reasons, the structure of existing aseptic connectors is still further optimized.

Disclosure of Invention

Aiming at the defects existing in the prior art, the invention aims to provide the connecting rod multi-stage locking sterile connecting device, which is characterized in that axial extrusion forces with different magnitudes are applied to a fluid passage of the connecting rod multi-stage locking sterile connecting device, when smaller axial extrusion forces are applied, isolation films are pulled away, the possibility of displacement of two sealing rings is reduced, a foundation is laid for establishing a reliable sterile fluid passage for increasing the axial extrusion forces subsequently, and the reliability of final sterile connection is ensured.

In order to achieve the above purpose, the present invention provides the following technical solutions: a connecting rod multistage locking sterile connection device comprises a main body, a connecting rod, a locking member, an isolation film and a sealing ring; the main body is provided with a tube head, and the sealing ring is fixed in the main body and communicated with the tube head; the isolating film is fixed on the main body and is attached to one side of the sealing ring, which is away from the pipe head; the connecting rod comprises a hinge part and a limiting part, the limiting part is arranged at one end of the hinge part, and the other end of the hinge part is hinged with the main body; the main body is provided with an abutting wall, and the hinge part and the abutting wall are symmetrically arranged on two sides of the axis of the pipe head respectively; the locking component is connected with the limiting part and is used for applying pressure with different magnitudes to the abutting wall, and part or all of the pressure is used for being converted into axial extrusion force to the sealing ring.

The invention is further provided with: the locking component comprises a cam part and a handle part, the cam part is hinged with the limiting part, and the handle part is fixedly connected with the cam part; the wheel surface of the cam part is divided into a plurality of sections, namely an initial section, a primary locking section and N locking sections in sequence, wherein N is greater than or equal to two, and according to the sequence, the radial distance from each section of wheel surface to the rotation axis of the cam part is sequentially increased; the interference wall is used for abutting against the wheel surface of the other sections except the initial section.

The invention is further provided with: the main body is provided with a lock hole which is arranged perpendicular to the axis direction of the tube head; when the abutting wall abuts against the N times of locking sections, the handle portion is inserted into the lock hole, and the wall of the lock hole, which is far away from one side of the isolation film, is in friction contact with the handle portion so as to prevent the cam portion from reversely rotating.

The invention is further provided with: the lock hole is provided with the locking piece on the pore wall of one side of keeping away from the isolation film, be provided with the locked groove that is used for holding the locking piece on the handle portion, one side that the locking piece is close to the isolation film is used for supporting tight locked groove inner wall.

The invention is further provided with: the locking component further comprises a convex hull, the convex hull is arranged on the M times of locking sections of the cam part, M is smaller than N, a cantilever is arranged on the abutting wall, and when the convex hull abuts against the cantilever, the abutting wall blocks one side, close to the (M+1) times of locking sections, of the convex hull.

The invention is further provided with: the conflict wall is provided with a chute for accommodating the convex hull.

The invention is further provided with: the limiting part is provided with a positioning mark, and the locking member is provided with a locking mark; when the positioning mark and the locking mark are aligned, the abutting wall abuts against the M locking sections, and M is smaller than N.

The invention is further provided with: the main body is provided with positioning bulges and positioning grooves for accommodating the positioning bulges, the positioning bulges and the positioning grooves are in one-to-one correspondence, and the positioning bulges and the positioning grooves which are mutually corresponding are respectively and symmetrically arranged on two sides of the axis of the pipe head.

The invention is further provided with: the device also comprises a pull ring which is fixedly connected with the isolation film.

The invention is further provided with: the pull ring is provided with a male buckle and a spigot for being clamped with the male buckle.

The invention is further provided with: the inner side of the sealing ring is provided with a first annular groove, the outer side of the sealing ring is provided with a second annular groove, and the groove walls of the first annular groove and the second annular groove are arc-shaped.

The invention is further provided with: the cross-sectional area of the first annular groove is greater than the cross-sectional area of the second annular groove.

The invention is further provided with: the protective cover is positioned on one side of the isolating film, which is away from the main body, and is detachably and fixedly connected with the main body.

The invention also provides a sterile butt joint device, which comprises a first sterile connecting device and a second sterile connecting device, wherein fluid channels are arranged in the first sterile connecting device and the second sterile connecting device, the first sterile connecting device and the second sterile connecting device form a sterile circulation channel for fluid to flow after being in butt joint, and the first sterile connecting device and the second sterile connecting device are locked by the connecting rod in a multistage manner.

The invention also provides a sterile connection system which comprises a first container, a second container and a sterile connector for communicating the first container and the second container, wherein the sterile connector is adopted.

The invention also provides a sterile connection method which is applied to the connecting rod multistage locking sterile connection device and comprises the following steps:

s1, providing two connecting rod multistage locking sterile connection devices with the same structure, and performing sterile treatment on both sides of two isolation films;

s2, butting the two connecting rod multistage locking sterile connection devices to enable one sides of the two isolation films, which deviate from the corresponding sealing rings, to be attached, aligning the two sealing rings, and rotating the two connecting rods to enable the locking member of each connecting rod multistage locking sterile connection device to be opposite to the abutting wall;

s3, applying pressure to the abutting wall through the locking component to enable the two isolation films to be closely attached, and extracting the two isolation films to form a sterile fluid passage;

s4, increasing the pressure exerted by the locking component on the abutting wall, increasing the axial extrusion received by the two sealing rings, and reinforcing the sterile fluid passage.

In summary, compared with the prior art, the invention has the following beneficial effects:

1. the invention has no male-female separation, and a user does not need to waste time and experience for distinguishing the male and female when constructing the sterile fluid channel, thereby improving the sterile connection efficiency.

2. The construction of the sterile fluid passage is realized by applying axial extrusion forces with different magnitudes to the sealing rings, so that the possibility of displacement of the two sealing rings when the isolating film is pulled away is effectively reduced, and the reliability of the sterile fluid passage is ensured.

3. According to the invention, the pull ring which can be connected in a buckling manner is additionally arranged on the isolation films, and the two isolation films are removed simultaneously through the buckling connection of the pull ring.

4. According to the invention, the first annular groove and the second annular groove are arranged inside and outside the sealing ring, so that the variation of CV value in the sealing ring is reduced.

Drawings

FIG. 1 is a schematic view of a connecting rod multi-stage locking aseptic connecting apparatus;

FIG. 2 is a front view of the connecting rod multi-stage locking aseptic connecting apparatus;

FIG. 3 is a side view of a connecting rod multi-stage locking aseptic connection apparatus;

FIG. 4 is a top view of the connecting rod multi-stage locking aseptic connection apparatus;

FIG. 5 is a schematic diagram showing an isolation film;

FIG. 6 is a cross-sectional view showing the internal structure of the main body;

FIG. 7 is a schematic diagram of a two-bar multi-stage locking aseptic connection apparatus prior to connection;

FIG. 8 is a cross-sectional view of an initial segment of the cam portion as opposed to the interference wall;

FIG. 9 is a schematic view of a two-bar multi-stage locking aseptic connecting apparatus in a one-time locked condition;

FIG. 10 is a cross-sectional view of the two-link multi-stage locking aseptic connecting apparatus in a one-time locked condition;

FIG. 11 is a schematic view of a two-bar multi-stage locking aseptic connecting apparatus in a secondary locked condition;

FIG. 12 is a cross-sectional view of the two-bar multi-level locking aseptic connecting apparatus in a secondary locked condition;

fig. 13 is a full cross-sectional view of the seal ring.

In the figure: 1. a main body; 11. a tube head; 12. a conflicting wall; 121. a chute; 122. a cantilever; 13. a lock hole; 14. a locking piece; 2. a connecting rod; 21. a hinge part; 22. a limit part; 221. positioning marks; 3. a locking member; 31. a cam section; 32. a handle portion; 321. a locking groove; 322. locking the mark; 33. convex hulls; 4. a separation film; 5. a seal ring; 51. a first annular groove; 52. a second annular groove; 6. a protective cover; 61. a claw; 71. positioning the bulge; 72. a positioning groove; 8. a pull ring; 81. a male buckle; 82. and (5) a spigot.

Detailed Description

The technical solutions of the present invention will be clearly described below with reference to the accompanying drawings, and it is obvious that the described embodiments are not all embodiments of the present invention, and all other embodiments obtained by a person skilled in the art without making any inventive effort are within the scope of protection of the present invention.

It should be noted that, the positional or positional relationship indicated by the terms such as "center", "upper", "lower", "horizontal", "left", "right", "front", "rear", "lateral", "longitudinal", etc. are based on the positional or positional relationship shown in the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or element to be referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention.

As shown in fig. 1 to 6, in a preferred embodiment of the present invention, a connecting rod multi-stage locking aseptic connection apparatus is a basic structure, and the connecting rod multi-stage locking aseptic connection apparatus includes a main body 1, a connecting rod 2, a locking member 3, an isolation film 4, and a sealing ring 5.

The main body 1 is provided with a tube head 11, in this embodiment, the tube head 11 is a pagoda-type tube head, and the pagoda-type tube head has stronger connection strength with other fluid channels. The sealing ring 5 is fixed in the main body 1 and is communicated with the pipe head 11, and one side of the sealing ring 5, which is away from the pipe head, protrudes out of one side of the main body, which is away from the pipe head; the isolating film 4 is fixed on the main body 1 and is attached to one side of the sealing ring 5 away from the pipe head 11, and the isolating film 4 is welded on the main body 1 in the embodiment; the connecting rod 2 comprises a hinge part 21 and a limit part 22, wherein the limit part 22 is arranged at one end of the hinge part 21, and the other end of the hinge part 21 is hinged with the main body 1; the main body 1 is provided with an abutting wall 12, and the hinge part 21 and the abutting wall 12 are symmetrically arranged on two sides of the axis of the pipe head 11 respectively; the locking member 3 is connected to the limiting portion 22, and the locking member 3 is configured to apply pressure of different magnitudes to the abutting wall 12, and part or all of the pressure is configured to be converted into an axial pressing force on the seal ring 5.

The hinge 21 and the interference wall 12 are in this embodiment distributed 180 ° around the axis of the tube head 11.

Specifically, the present embodiment further includes a protective cover 6, where the protective cover 6 is located on a side of the isolation film 4 facing away from the main body 1 and is detachably and fixedly connected to the main body 1, so as to protect the isolation film 4. When the two-connecting-rod multistage locking sterile connecting device needs to be connected, the protective cover 6 is detached from the main body 1. In this embodiment, four claws 61 are provided on the protection cover 6, and connection between the protection cover 6 and the main body 1 is achieved through clamping between the four claws 61 and the main body 1.

As shown in fig. 7-12, the locking member 3 includes a cam portion 31 and a handle portion 32, the cam portion 31 is hinged with the limit portion 22, and the handle portion 32 is fixedly connected with the cam portion 31; the wheel surface of the cam part 31 is divided into a plurality of sections, which are an initial section, a primary locking section and N locking sections in sequence, wherein N is greater than or equal to two, and according to the sequence, the radial distance from each section of the wheel surface to the rotation axis of the cam part 31 is increased in sequence; the abutment wall 12 is intended to abut against other segment flanks than the initial segment. As the radial distance of the wheel surface section against the abutment wall 12 from the rotation axis of the cam portion 31 increases, the pressure exerted by the cam portion 31 against the abutment wall 12 increases accordingly, thereby increasing the axial compression force to which the seal ring 55 is subjected. In this embodiment, the cam 31 has a cam surface divided into three sections, namely an initial section, a primary locking section and a secondary locking section.

Specifically, the abutting wall 12 is configured as an arc-shaped abutting wall to increase the contact area between the abutting wall 12 and the cam portion 31.

Specifically, the main body 1 is provided with a lock hole 13 which is arranged perpendicular to the axial direction of the tube head 11; when the abutting wall 12 abuts against the N number of locking sections, i.e. the secondary locking section in this embodiment, the handle portion 32 is inserted into the lock hole 13, and the wall of the lock hole 13 on the side away from the isolation film 4 is in frictional contact with the handle portion 32, so as to prevent the cam portion from rotating reversely. By the arrangement, even if the two-connecting-rod multi-stage locking sterile connecting device is affected by vibration after being connected, the position of the locking member 3 is not easy to change, and the connection reliability of the two-connecting-rod multi-stage locking sterile connecting device is further improved.

Specifically, the hole wall of the side, far away from the isolation film 4, of the lock hole 13 is provided with a locking piece 14, the handle portion 32 is provided with a locking groove 321 for accommodating the locking piece 14, and the side, close to the isolation film 4, of the locking piece 14 is used for abutting against the inner wall of the locking groove 321. By the arrangement, the main body 1 is only in friction contact with the handle part 32 through the locking block 14, so that the contact area between the main body 1 and the handle part 32 is reduced, the pressure of the main body 1 on the handle part 32 is improved, the friction force between the main body 1 and the handle part 32 is increased, and the possibility that the handle part 32 is separated from the lock hole 13 due to vibration is further reduced.

Specifically, in the present embodiment, when the contact wall 12 is abutted against the N times of locking section of the cam portion 31, that is, the second time of locking section in the present embodiment, the contact wall 12 is elastically deformed, so as to increase the fastening force between the contact wall 12 and the cam portion 31, and further improve the connection reliability of the two-link multistage locking sterile connection device. The elastic deformation of the abutting wall 12 when abutting against the secondary locking section is shown in fig. 12 where the main body 1 overlaps the cam portion 31.

Specifically, the locking member 3 further includes a convex hull 33, where the convex hull 33 is disposed on M locking segments of the cam portion 31, where M is smaller than N, and the M locking segments in this embodiment are primary locking segments. The cantilever 122 is disposed on the abutting wall 12, and when the convex hull 33 abuts against the cantilever 122, the abutting wall 12 is blocked at one side of the convex hull 33 close to the (m+1) locking section, so as to prevent the cam portion 31 from reversely rotating. In this embodiment, the (m+1) secondary locking section is a secondary locking section.

In this embodiment, the cantilever arm 122 is provided with a bevel for guiding the convex hull 33 to scratch the cantilever arm 122, so as to prevent the cantilever arm 122 from blocking the rotation of the cam portion 31.

Specifically, the sliding groove 121 for accommodating the convex hull 33 is formed in the abutting wall 12, and the possibility that the convex hull 33 abuts against the abutting wall 12 is effectively avoided due to the sliding groove 121, so that the convex hull 33 cannot interfere with the abutting of the primary locking section and the abutting wall 12.

Specifically, the limiting portion 22 is provided with a positioning mark 221, and the locking member 3 is provided with a locking mark 322; the locating marks 221 and the locking marks 322 can help the user determine the relative position between the M locking segments and the interference wall 12, with the interference wall 12 abutting against the M locking segments when the locating marks 221 and the locking marks 322 are aligned, with M being less than N. In this embodiment, the M locking segments are primary locking segments.

Specifically, the main body 1 is provided with a positioning protrusion 71 and a positioning groove 72 for accommodating the positioning protrusion 71, the positioning protrusion 71 and the positioning groove 72 are in one-to-one correspondence, and the positioning protrusion 71 and the positioning groove 72 which are corresponding to each other are symmetrically arranged at two sides of the axis of the pipe head 11 respectively. When all the positioning projections 71 of one connecting rod multi-stage locking aseptic connecting apparatus are inserted into all the positioning recesses 72 of the other connecting rod multi-stage locking aseptic connecting apparatus, the seal rings 5 of the two connecting rod multi-stage locking aseptic connecting apparatuses are aligned. In this embodiment, two positioning protrusions 71 and two positioning grooves 72 are provided, and all the positioning protrusions 71 and the positioning grooves 72 are arranged at intervals and uniformly distributed around the axis of the pipe head 11.

Specifically, the present embodiment further includes a pull ring 8, where the pull ring 8 is fixedly connected to the release film 4, so that the user can remove the release film 4 from the main body 1.

Specifically, the pull ring 8 is provided with a male buckle 81 and a spigot 82 for being clamped with the male buckle 81, and the pull ring 8 of the two-connecting-rod multi-stage locking sterile connecting device can be fixed together through the cooperation of the male buckle 81 and the spigot 82.

As shown in fig. 13, a first annular groove 51 is formed on the inner side of the sealing ring 5, and a groove wall in the cross section of the first annular groove 51 is in a circular arc shape. When the sealing ring 5 is axially extruded, the first annular groove 51 can limit the expansion of the inner side of the sealing ring 5, so that the variation of the fluid coefficient, namely the CV value, in the sealing ring 5 is reduced.

Specifically, a second annular groove 52 is disposed on the outer side of the sealing ring 5, the groove wall in the cross section of the second annular groove 52 is circular arc, and the circular arc groove wall center line of the first annular groove 51 is coplanar with the circular arc groove wall center line of the second annular groove 52. The first annular groove 51 and the second annular groove 52 are matched with each other to limit expansion of the inner side and the outer side of the sealing ring 5, and further reduce the variation of CV values in the sealing ring 5.

Specifically, the groove depth of the first annular groove 51 is greater than or equal to the groove depth of the second annular groove 52, wherein the groove depth refers to the depth of the groove perpendicular to the axial direction of the pipe head 11, and meanwhile, the groove wall radius of the first annular groove 51 is greater than the groove wall radius of the second annular groove 52, so that the cross-sectional area of the second annular groove 52 is ensured to be smaller than that of the first annular groove 51, and when the sealing ring 5 is subjected to axial pressure, the expansion trend of the inner side and the outer side of the sealing ring 5 is relatively balanced, and the variation of the CV value in the sealing ring 5 is further reduced.

The embodiment also provides an aseptic butt joint device, which comprises a first aseptic connecting device and a second aseptic connecting device, wherein the first aseptic connecting device and the second aseptic connecting device are internally provided with fluid channels, the first aseptic connecting device and the second aseptic connecting device form an aseptic circulating channel for fluid to flow after being in butt joint, and the first aseptic connecting device and the second aseptic connecting device are respectively locked with the aseptic connecting device by adopting the connecting rod multistage locking mode.

The embodiment also provides a sterile connection system, which comprises a first container, a second container and a sterile connector for communicating the first container and the second container, wherein the sterile connector is adopted by the sterile connector.

The embodiment also provides an aseptic connection method which is applied to the connecting rod multistage locking aseptic connection device and comprises the following steps:

s1, providing two connecting rod multistage locking sterile connection devices with the same structure, and carrying out sterile treatment on two sides of two isolation films 4; specifically, two connecting rod multistage locking sterile connection devices with the same structure are provided, the protective cover 6 is removed, two surfaces of the two isolation films 4 are subjected to sterile treatment, and the two tube heads 11 are connected with containers or pipelines which need to be subjected to sterile connection.

S2, butting the two connecting rod multistage locking sterile connection devices, enabling one sides of the two isolation films 4, which deviate from the corresponding sealing rings 5, to be attached, enabling the two sealing rings 5 to be aligned, rotating the two connecting rods 2, enabling the locking member 3 of each connecting rod multistage locking sterile connection device to be opposite to the abutting wall 12, and achieving the state that the initial section of the convex wheel part 31 is aligned with the abutting wall 12 in the embodiment.

S3, applying pressure to the abutting wall 12 through the locking component 3 to enable the two isolation films 4 to be closely attached, and drawing out the two isolation films 4 to form a sterile fluid passage; the rotatable cam portion 31 in the present embodiment presses the abutting wall 12 by abutting the abutting wall 12 against the other tread sections of the cam portion 31 other than the initial section. When the two isolation films 4 are pulled out, the two pull rings 8 can be connected together through the cooperation of the male buckle 81 and the spigot 82, so that the two isolation films 4 can be removed simultaneously.

And S4, increasing the pressure applied by the locking member 3 to the abutting wall 12, namely rotating to a state that the abutting wall 12 abuts against the N times of locking sections, increasing the axial extrusion received by the two sealing rings 5, reinforcing the sterile fluid passage, and improving the reliability of the sterile fluid passage.

In summary, in this embodiment, the aseptic fluid passage is constructed by applying axial extrusion forces with different magnitudes to the sealing rings 5, so that the possibility of displacement of the two sealing rings 5 when the isolation film 4 is pulled away is effectively reduced, and the reliability of the aseptic fluid passage is ensured. Secondly, the embodiment is of a design which is not separated from a male part and a female part, and can improve sterile connection efficiency. In addition, in this embodiment, the pull ring 8 capable of being connected in a snap manner is additionally installed on the isolation film 4, and the two isolation films 4 can be removed simultaneously through the snap connection of the pull ring 8. Finally, the structure of the sealing ring 5 is optimized, and the variation of the CV value in the sealing ring 5 is reduced through the design of the groove.

The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A connecting rod multi-stage locking sterile connection device, characterized by: including a main body (1), a connecting rod (2), a locking member (3), an isolation film (4) and a sealing ring (5); A pipe head (11) is provided on the main body (1), the sealing ring (5) is fixed in the main body (1) and communicates with the pipe head (11); the isolation film (4) is fixed on the main body (1) and fit with the side of the sealing ring (5) away from the pipe head (11); the connecting rod (2) includes a hinge portion (21) and a limiting portion (22), and the limiting portion (22) is arranged on the hinged joint. One end of the hinge part (21), the other end of the hinge part (21) is hinged with the main body (1); the main body (1) is provided with a resistance wall (12), the hinge part (21) and the resistance wall (12) are respectively on the tube The two sides of the axis of the head (11) are symmetrically arranged; the locking member (3) is connected to the limiting portion (22), and the locking member (3) is used to apply different sizes of pressure to the resistance wall (12). The pressure Part or all of is used to convert into axial extrusion force on the sealing ring (5).

2. A connecting rod multi-stage locking sterile connection device according to claim 1, characterized in that: the locking member (3) includes a cam portion (31) and a handle portion (32), and the cam portion (31) 31) is hinged with the limiting part (22), and the handle part (32) and the cam part (31) are fixedly connected; the wheel surface of the cam part (31) is divided into multiple sections, namely the initial section, the primary locking section,..., N times of locking segments, where N is greater than or equal to two. According to this sequence, the radial distance of each segment of the wheel surface from the rotation axis of the cam part (31) increases sequentially; the resistance wall (12) is used to interact with other than the initial segment The other segments are offset by each other.

3. A connecting rod multi-stage locking sterile connection device according to claim 2, characterized in that: the main body (1) is provided with a lock hole (13) perpendicular to the axis of the tube head (11). ); when the resistance wall (12) is against the N locking sections, the handle portion (32) is inserted into the lock hole (13), and the lock hole (13) is away from the hole wall on the side of the isolation film (4) and the handle portion (32) ) friction contact to prevent the cam part (31) from rotating reversely.

4. A connecting rod multi-stage locking sterile connection device according to claim 3, characterized in that: a locking block ( 14), the handle part (32) is provided with a lock groove (321) for accommodating the lock block (14), and the side of the lock block (14) close to the isolation film (4) is used to resist the lock groove (321) inner wall.

5. A connecting rod multi-stage locking sterile connection device according to claim 2, characterized in that: the locking member (3) further includes a convex hull (33), and the convex hull (33) is provided with On the M locking sections of the cam part (31), M is smaller than N, and a cantilever (122) is provided on the conflicting wall (12). When the convex bulge (33) and the cantilever (122) are in contact, the conflicting The wall (12) blocks the side of the convex hull (33) close to the (M+1) secondary locking section.

6. A connecting rod multi-level locking sterile connection device according to claim 5, characterized in that a chute (121) for accommodating the bulge (33) is provided on the resistance wall (12).

7. A connecting rod multi-stage locking sterile connection device according to claim 2, characterized in that: the limiting part (22) is provided with a positioning mark (221), and the locking member (3 ) is provided with a locking mark (322); when the positioning mark (221) and the locking mark (322) are aligned, the conflicting wall 12 offsets the M locking sections, and M is smaller than N.

8. A connecting rod multi-stage locking sterile connection device according to any one of claims 1 to 7, characterized in that: the main body (1) is provided with a positioning protrusion (71) and a positioning protrusion for accommodating the positioning The positioning groove (72) of the protrusion (71) corresponds to the positioning protrusion (71) and the positioning groove (72) one by one. The corresponding positioning protrusion (71) and the positioning groove (72) are respectively located on the pipe head. (11) Both sides of the axis are arranged symmetrically.

9. A connecting rod multi-level locking sterile connection device according to any one of claims 1 to 7, characterized in that: it also includes a pull ring (8), the pull ring (8) and the isolation film (4 ) fixed connection.

10. A connecting rod multi-level locking sterile connection device according to claim 9, characterized in that: the pull ring (8) is provided with a male buckle (81) and is used to connect with the male buckle (81) Snap-on stop (82).

11. A connecting rod multi-stage locking sterile connection device according to any one of claims 1 to 7, characterized in that: a first annular groove (51) is provided inside the sealing ring (5), and the A second annular groove (52) is provided outside the sealing ring (5), and the groove walls of the first annular groove (51) and the second annular groove (52) are both arc-shaped.

12. A connecting rod multi-level locking sterile connection device according to claim 11, characterized in that: the cross-sectional area of the first annular groove (51) is larger than the cross-sectional area of the second annular groove (52) area.

13. A connecting rod multi-level locking sterile connection device according to any one of claims 1 to 7, characterized in that: it also includes a protective cover (6), the protective cover (6) is located on the isolation film (4 ) is away from the side of the main body (1) and is removably and fixedly connected to the main body (1).

14. A sterile docking device, including a first sterile connection device and a second sterile connection device. Both the first sterile connection device and the second sterile connection device are provided with fluid channels inside the first sterile connection device and the second sterile connection device. The second aseptic connection device is docked to form a sterile circulation channel for fluid flow, which is characterized in that: the first aseptic connection device and the second aseptic connection device both adopt the connecting rod according to any one of claims 1-13 Multi-stage locking sterile connection device.

15. A sterile connection system, including a first container, a second container, and a sterile docking device connecting the first container and the second container, characterized in that: the sterile docking device adopts a sterile docking device as claimed in claim 14 Sterile docking adapter.

16. A sterile connection method, characterized in that: applied to the connecting rod multi-stage locking sterile connection device according to any one of claims 1-13, including the following steps:

S1. Provide two connecting rod multi-level locking sterile connection devices with the same structure, and perform sterile treatment on both sides of the two isolation films (4);

S2. Connect the two connecting rod multi-stage locking sterile connection devices so that the sides of the two isolation films (4) facing away from their corresponding sealing rings (5) are in contact with each other. At the same time, align the two sealing rings (5) and rotate the two connecting rod, so that the locking member (3) of each connecting rod multi-stage locking sterile connection device is opposite to the resistance wall (12);

S3. Apply pressure to the resisting wall (12) through the locking member (3) so that the two isolation films (4) are in close contact with each other, and then pull out the two isolation films (4) to form a sterile fluid path;

S4. Increase the pressure exerted by the locking member (3) on the resistance wall (12), increase the axial compression of the two sealing rings (5), and strengthen the sterile fluid passage.