CN117481859A - Magnetic resonance-mediated ischemic stroke induction device and method - Google Patents
Magnetic resonance-mediated ischemic stroke induction device and method Download PDFInfo
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- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
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- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
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Abstract
The invention discloses a magnetic resonance mediated ischemic cerebral apoplexy inducing device, which comprises: the optical fiber pushing unit comprises a push-pull rod and a sleeve, wherein the push-pull rod is inserted into the sleeve, and a cavity is formed between the push-pull rod and the sleeve; the optical fiber is arranged at the tail end of the push-pull rod; when the volume of the cavity is changed, the push-pull rod stretches to drive the optical fiber at the tail end to displace. The invention also discloses a magnetic resonance mediated ischemic cerebral apoplexy induction method, which comprises the following steps: anesthesia is carried out on experimental animals and the experimental animals are fixed on an ischemic cerebral apoplexy induction device mediated by magnetic resonance; image positioning is carried out by magnetic resonance, and optical fiber fixed-point implantation is carried out by adopting an ischemic cerebral apoplexy inducing device; injecting a photosensitizer into the vascular system of the animal; the fiber is stimulated at one or more location sites and laser irradiation induces embolization. The magnetic resonance mediated ischemic cerebral apoplexy induction device and method provided by the invention can induce cerebral apoplexy in magnetic resonance, and provide reliable and safe experimental basis for clinical research.
Description
Technical Field
The invention relates to the technical field of experimental equipment, in particular to a magnetic resonance mediated ischemic cerebral apoplexy induction device and method.
Background
Stroke (Stroke) refers to a narrowing, occlusion or rupture of an artery in the brain caused by various factors, which causes acute cerebral blood circulation disorders and blood supply to the brain to be blocked, and then causes cerebral nerve dysfunction. Has become a disease with high morbidity and mortality. Cerebral stroke is divided into ischemic and hemorrhagic forms. Among them, ischemic cerebral apoplexy accounts for about 80%, and its causes include thrombosis (cerebral thrombosis of blood clot), embolism, hypoperfusion and venous thrombosis, which cause cerebral blood supply insufficiency, leading to brain tissue dysfunction and necrosis. Hemorrhagic stroke includes cerebral hemorrhage and subarachnoid hemorrhage, accounting for about 10% -27% of all stroke types.
Currently, nmr is clinically used to examine internal organ and tissue changes such as tumors, blood vessels, nerve compression, hydroorgan and ligaments in a subject. Meanwhile, MRI can present multi-angle and multi-plane imaging to all parts of the human body, is easier to analyze, and has obvious value for diagnosing early tumor and brain diseases. However, when the detection is performed, the object containing the metal substance cannot enter the detection space, and if the metal object enters the magnetic resonance machine room, the metal object is attracted by the magnetic field and may be quickly sucked into the machine, so that serious danger is caused. This constitutes a potential life hazard for both the patient and the medical staff and results in serious damage to the object and the machine itself. This may cause a fire or machine failure, causing expensive repair and maintenance costs to the equipment.
Currently, there are a number of ways to induce stroke in the brain of animals to build animal models of stroke, such as: (1) Rodent and non-human primate local craniotomy, endothelin-1 is administered to the local middle cerebral artery to induce vascular occlusion to achieve ischemia [ Dai P, huang H, zhang L, et al a pilot study on transient ischemic stroke induced with endothelin-1in the rhesus monkeys[J ]. Sci Rep,2017,7:45097 ]; (2) The winged approach craniotomy is followed by mechanical arterial occlusion resulting in ischemia [ Wu D, chen J, hussain M, et al selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: efficacy depending on eperfusion status [ J ]. J Cereb Blood Flow Metab,2020, 40 (7): 1415-1426 ]; (3) The micro embolic blocking method [ Wang CX, yaag Y, yang T, et al A focal embolic model of cerebral ischemia in rat: introduction and evaluation [ J ]. Brain Res Protocols,2001, (7): 115-200 ]; (4) intravascular thrombus blocking; [ Koizumi J, yoshida Y, nakazawa T, et al.
Experimental studies of ischemia brain edema: A new experimental model of cerebral embolismin rats in which recirculation can be introduced in the ischemia area [ J ]. Jpn J Stroke,1986,8:l-8 ]; (5) photochemically induced thrombosis; study of photochemically induced rat cerebral infarction models [ Li Gongge, zhang Maoyue, tong Etang ], stroke and neurological diseases 1996,3 (3): 126 ].
However, at present, no operation can be synchronously operated in a magnetic resonance machine room to induce operation, and various changes when the occurrence of the cerebral apoplexy is missed and observed, so that the development of medical treatment during the occurrence period of the cerebral apoplexy is a great obstacle.
Disclosure of Invention
The invention aims to provide a magnetic resonance mediated ischemic cerebral apoplexy induction device and a magnetic resonance mediated ischemic cerebral apoplexy induction method, which can induce cerebral apoplexy (Stroke) in magnetic resonance and provide reliable and safe experimental basis for clinical research.
The invention provides the following technical scheme:
a magnetic resonance mediated ischemic stroke inducing device, the device comprising:
the optical fiber pushing unit comprises a push-pull rod and a sleeve, wherein the push-pull rod is inserted into the sleeve, and a cavity is formed between the push-pull rod and the sleeve;
the optical fiber is arranged at the tail end of the push-pull rod;
when the volume of the cavity is changed, the push-pull rod stretches to drive the optical fiber at the tail end to displace.
Further, the device comprises a fiber laser connected with the optical fiber, and the light emission of the fiber laser is controlled by the control unit.
Further, as an aspect of the present invention, the apparatus includes:
the pressure push-pull unit comprises a first push-pull rod and a first sleeve, wherein the first push-pull rod is partially inserted into the first sleeve, and the first push-pull rod and the first sleeve form a first chamber;
the optical fiber pushing unit comprises a second push-pull rod and a second sleeve, wherein the second push-pull rod is partially inserted into the second sleeve, and a second cavity is formed between the second push-pull rod and the second sleeve; the second chamber is connected with the first chamber through a pipeline;
and fluid is distributed among the first chamber, the second chamber and the pipeline, the volume of the first chamber is changed through the expansion and contraction of the first push-pull rod, the volume of the second chamber is changed along with the expansion and contraction of the second push-pull rod, and the second push-pull rod drives the optical fiber at the tail end to displace.
When the first push-pull rod moves/stretches to change the size of the first chamber, fluid flows back between the first chamber and the second chamber through the light path, so that the size of the second chamber is adjusted accordingly, the second push-pull rod is driven to move to stretch, and then the tail end light ray is driven to displace.
Further, as an aspect of the present invention, the chamber is connected to a hydraulic pump, a pneumatic pump, or an electric motor through a pipe, and the volume of the chamber is changed by the hydraulic pump, the pneumatic pump, or the electric motor.
Further, the device comprises a rotary fixing seat and a rotary bracket, wherein one end of the rotary fixing seat is fixed with an optical fiber pushing unit, and the optical fiber pushing unit is used for adjusting the angle of the optical fiber pushing unit in the vertical direction (the angle of the optical fiber at the tail end of the push-pull rod or the optical fiber at the tail end of the second push-pull rod in the vertical direction); one end of the rotary support is connected with the rotary fixing seat and is used for adjusting the angle of the optical fiber pushing unit (the push-pull rod and the optical fiber at the tail end of the push-pull rod or the angle of the optical fiber at the tail end of the second push-pull rod and the optical fiber at the vertical direction) in the horizontal direction.
Further, the device comprises a placement table, a first fixing frame and a second fixing frame which are arranged on two sides of the placement table, wherein a placement space is formed between the first fixing frame and the placement table and between the second fixing frame and the placement table; the other end of the rotary support is connected with the first fixing frame or the second fixing frame.
Further, the fluid is a gas or a liquid, the gas is selected from air, and the liquid is selected from purified desquamated water or glycerin.
The magnetic resonance mediated ischemic cerebral apoplexy induction device provided by the invention can induce cerebral ischemia in magnetic resonance device equipment, induce cerebral ischemia in a magnetic resonance space with high magnetic field quantity, and perform single multi-point induction/stimulation or multiple multi-point induction/stimulation by means of optical fiber fixed-point implantation so as to cause embolism at different positions in the brain, thereby simulating different types of strokes, generating cerebral conditions which are closer to actual conditions, providing reliable and safe experimental basis for clinical research, and being beneficial to treatment experiment.
The invention also provides a magnetic resonance mediated ischemic cerebral apoplexy induction method, which comprises the following steps:
(1) Anesthesia is carried out on experimental animals and the experimental animals are fixed on the magnetic resonance mediated ischemic cerebral apoplexy induction device;
(2) Image positioning is carried out by magnetic resonance, and optical fiber fixed-point implantation is carried out by adopting an ischemic cerebral apoplexy inducing device;
(3) Injecting a photosensitizer into the vascular system of the animal;
(4) The fiber is stimulated at one or more location sites and laser irradiation induces embolization.
Further, in step (2): when the volume of the cavity or the second cavity is increased, the push-pull rod or the second push-pull rod stretches to drive the optical fiber to be implanted; and the implantation position of the optical fiber is controlled by rotating the fixing seat and the rotating bracket.
Further, the method controls stroke embolic volume by adjusting laser shot intensity, photosensitizer concentration, and stimulation duration.
Further, in the step (4), during the fixed-point implantation of the optical fiber, the angle of the push-pull rod or the second push-pull rod in the vertical direction and the horizontal direction is respectively adjusted through the fixing seat and the rotating bracket, so that the optical fiber stops at two or more positions to induce embolism of different brain areas.
The magnetic resonance mediated ischemic cerebral apoplexy induction method provided by the invention can be used for manufacturing single-point or multi-point stimulation with different depths or multi-point stimulation with different positions, and can be used for controlling the embolism volume of the cerebral apoplexy by adjusting parameters (such as laser intensity, photosensitizer concentration, stimulation duration time and the like) induced by the cerebral apoplexy so as to simulate various possible conditions and facilitate various tests of clinical experiments.
Therefore, compared with the prior art, the magnetic resonance mediated ischemic cerebral apoplexy induction device and method provided by the invention overcome the defect that the induction operation can not be carried out with magnetic resonance in the past, can carry out induction with different depths and multiple points, and can track the occurrence of lesions in real time, and are methods or equipment which cannot be achieved by the traditional method.
Drawings
FIG. 1 is a schematic perspective view of a side front view of a magnetic resonance-mediated ischemic stroke inducing device according to an embodiment of the present invention.
Fig. 2 is a schematic perspective view of a magnetic resonance-mediated ischemic stroke inducing device according to an embodiment of the present invention.
FIG. 3 is a schematic perspective view of a magnetic resonance-mediated ischemic stroke inducing device according to one embodiment of the present invention.
FIG. 4 is a flow chart of a method for magnetic resonance mediated ischemic stroke induction in an embodiment of the present invention.
Detailed Description
In order to more particularly describe the present invention, the following detailed description of the technical scheme of the present invention is provided with reference to the accompanying drawings and the specific embodiments. It should be understood that these descriptions are merely provided to further illustrate the features and advantages of the present invention and are not intended to limit the scope of the claims.
As shown in fig. 1-3, the magnetic resonance mediated ischemic cerebral apoplexy inducing device 1 according to the present embodiment is combined with a placement table 11, and a first fixing frame 12 and a second fixing frame 13 are respectively disposed on two sides of the placement table 11, and the first fixing frame 12 and the second fixing frame 13 form a head placement space 14 with the placement table 11.
The induction device 1 comprises an optical fiber propulsion mechanism 15, and the specific structure is as follows:
the pressure push-pull unit 151 includes a first push-pull rod 1511 and a first sleeve 1512, the first push-pull rod 1511 is partially inserted into the first sleeve 1512, and the first push-pull rod 1511 and the first sleeve 1512 form a first chamber 1513;
the optical fiber pushing unit 152 includes a second push-pull rod 1521 and a second sleeve 1522, wherein the second push-pull rod 1521 is partially inserted into the second sleeve 1522, and a second chamber 1523 is formed between the second push-pull rod 1521 and the second sleeve 1522;
an optical fiber 153 disposed at the end of the second push-pull rod 1521;
the optical fiber propulsion units 152 of the pressure push-pull units 151 are connected through pipelines;
fluid is distributed among the first chamber 1513, the second chamber 1523 and the pipeline, the volume of the first chamber 1513 is changed through the expansion and contraction of the first push-pull rod 1511, the volume of the second chamber 1523 is changed along with the change, and the second push-pull rod 1521 expands and contracts to drive the optical fiber 153 at the tail end to displace.
The specific working process of the optical fiber propulsion mechanism 15 is as follows:
when the first push-pull rod 1511 moves to change the size of the first chamber 1513, the fluid flows between the second chamber 1523 and the first chamber 1513 via the conduit, so that the size of the second chamber 1523 is adjusted, i.e., the second push-pull rod 1521 is moved. For example: when the first push-pull rod 1511 is pressed inward, the space of the first chamber 1513 is forced to be smaller, so that the fluid moves toward the second chamber 1523 through the pipe body, and thus the second chamber 1523 presses the second push-pull rod 1521 to move outward due to the inflowing fluid, so that the space volume of the second chamber 1523 is increased. During this process, the outward movement of the second push-pull rod 1521 represents the further outward movement (i.e., deep into the brain) of the optical fiber 153. Conversely, when the space of the first chamber 1513 is enlarged due to the outward pulling of the first push-pull rod 1511, the fluid will flow back to the first chamber 1513 again, and the pressure of the second chamber 1523 is reduced due to the decrease of the fluid, so that the second push-pull rod 1521 will retract inwards, which represents the forward and reverse movement of the optical fiber 153, which is the direction of moving out from the brain.
The fluid may be air, a specific gas or a liquid.
In this embodiment, the optical fiber 153 is disposed at one end of the second push-pull rod 1521. The induction device 1 further comprises a rotation fixing seat 154 and a rotation bracket 18, wherein one end of the rotation fixing seat 154 is fixed with the optical fiber propulsion unit 152, and is used for adjusting the angle of the optical fiber propulsion unit 152 in the vertical direction, so that the optical fiber propulsion unit 152 can vertically rotate; one end of the rotary bracket 18 is connected with a rotary fixing seat 154 for adjusting the angle of the optical fiber propulsion unit 152 in the horizontal direction; the other end of the rotary bracket 18 is arranged on the second fixing frame 13.
In the present embodiment, at least one head position auxiliary positioning mechanism 16 is provided beside the placement table 11. In addition, the head placement space 14 and the head position auxiliary positioning mechanism 16 are used for respectively accommodating and positioning the head of the experimental animal (such as macaque) so as to facilitate the ischemic brain modeling.
In the present embodiment, a fiber laser 17 is further included and connected to the optical fiber 153, the laser 17 can control the light emitting intensity and duration of the optical fiber 153, and the pressure pushing unit 151 further controls the position and depth of the optical fiber 153.
In this embodiment, the device further comprises two measuring tapes 19, which are parallel to each other and have equal heights, and are respectively disposed between the first fixing frame 12 and the second fixing frame 13, so as to measure the length of the head of the experimental animal.
As another embodiment of the present invention, the pressure push-pull unit 151 may be replaced with a hydraulic pump, a pneumatic pump, or an electric motor to control the hydraulic propulsion, and the same control effect may be achieved by simply displacing the metal-containing structure, the motor, or the electric part outside the Magnetic Resonance Imaging (MRI) room and connecting the same through a pipeline.
Referring to fig. 4, a flowchart illustrating steps of a method for operating an ischemic stroke device for magnetic resonance imaging according to the present invention includes the following steps:
s1: fixing the experimental animal on the magnetic resonance mediated ischemic cerebral apoplexy induction device 1;
s2: positioning in combination with the image;
s3: performing optical fiber 153 site-specific implantation by adopting a magnetic resonance mediated ischemic stroke induction device 1;
s4: single or multi-point stimulation is performed, resulting in embolism.
In step S4, during the fixed-point implantation of the optical fiber 153, the optical fiber pushing unit 152 is adjusted by the pressure pushing unit 151, the rotation fixing base 154 and the rotation bracket 18, so that the optical fiber 153 is stopped at two or more positions to induce embolism at different positions.
Furthermore, since the induction device 1 provided by the invention is made of non-metal materials, namely various plastic materials or materials which are not affected by magnetic force, the induction device can be controlled in real time in Magnetic Resonance Imaging (MRI).
In addition, the method for operating the magnetic resonance mediated ischemic cerebral apoplexy induction device provided by the invention comprises the following steps: image positioning is carried out by matching with magnetic resonance, namely image scanning of a magnetic resonance structure is carried out, ischemia sites are determined, accurate three-dimensional space coordinates of the ischemia sites are measured, and modeling of brain structure positioning and blood vessel positioning is realized.
In addition, the operation method of the magnetic resonance mediated ischemic cerebral apoplexy inducing device provided by the invention is characterized in that the optical fiber is precisely implanted into the molding position at a fixed point, and after rose bengal is injected intravenously, the optical fiber laser 17 is used for carrying out laser irradiation to induce vascular occlusion, so as to construct focal cerebral embolism.
Furthermore, the magnetic resonance imaging can also evaluate the nerve injury of the brain after modeling so as to perfect the image evaluation system of the existing cerebral ischemia animal model.
The detailed operation method of this embodiment is as follows:
1. anesthesia: the experimental animals were anesthetized and fixed to the ischemic stroke induction device suitable for magnetic resonance mediation.
2. Photosensitive dye injection: a photosensitizing dye (e.g., rose bengal) is injected into the vascular system of an animal. The photosensitizing dye circulates in the blood vessel and subsequently generates reactive oxygen species (reactive oxygen species, ROS) under the influence of light, resulting in localized vascular endothelial cell damage, thrombosis and vascular occlusion.
3. Illumination: the light source is irradiated on cerebral blood vessels at different positions of animals through laser or optical fiber, and middle cerebral artery (middle cerebral artery, MCA), cortical blood vessels, deep cerebral small blood vessels and the like are usually selected. The intensity and timing of the illumination needs to be precisely controlled to ensure adequate thrombosis and occlusion of the blood vessel.
4. Thrombosis and vascular occlusion: under the action of light, active oxygen generated by the photosensitive dye causes local vascular endothelial cell injury, triggers platelet aggregation and thrombosis, finally blocks cerebral vessels and simulates the pathophysiological process of a human apoplexy patient.
5. Model evaluation: the severity of cerebral ischemia and the success rate of the model caused by the photointerruption method are evaluated by methods such as neural function scoring, brain tissue staining, cerebral infarction volume measurement and the like.
In summary, the magnetic resonance mediated ischemic cerebral apoplexy induction method and the magnetic resonance mediated ischemic cerebral apoplexy induction method provided by the invention can generate an induction ischemic cerebral model to simulate the treatment of cerebral apoplexy of a human body, and the model can provide reliable and safe experimental basis for clinical research.
The above examples are only preferred embodiments of the present invention, and are merely for illustrating the present invention, not for limiting the present invention, and those skilled in the art should not be able to make any changes, substitutions, modifications and the like without departing from the spirit of the present invention.
Claims (10)
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| WO1999015237A1 (en) * | 1997-09-24 | 1999-04-01 | United States Surgical Corporation | Devices and methods for performing transmyocardial revascularization |
| US6471692B1 (en) * | 1998-06-24 | 2002-10-29 | Laser Industries Ltd. | System and method for manipulating movement of an energy emitting device within a body cavity |
| US20030191461A1 (en) * | 2000-04-07 | 2003-10-09 | Synergetics, Inc., A Corporation | Directional laser probe |
| CN101299972A (en) * | 2005-10-31 | 2008-11-05 | 爱尔康公司 | Extended Trumpet Illuminator |
| US20160310323A1 (en) * | 2015-04-24 | 2016-10-27 | Katalyst Surgical, Llc | Steerable laser probe and methods of use |
| CN116392727A (en) * | 2023-04-23 | 2023-07-07 | 张晨 | Implantable Fiber Optic Devices |
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2023
- 2023-11-02 CN CN202311447459.1A patent/CN117481859B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999015237A1 (en) * | 1997-09-24 | 1999-04-01 | United States Surgical Corporation | Devices and methods for performing transmyocardial revascularization |
| US6471692B1 (en) * | 1998-06-24 | 2002-10-29 | Laser Industries Ltd. | System and method for manipulating movement of an energy emitting device within a body cavity |
| US20030191461A1 (en) * | 2000-04-07 | 2003-10-09 | Synergetics, Inc., A Corporation | Directional laser probe |
| CN101299972A (en) * | 2005-10-31 | 2008-11-05 | 爱尔康公司 | Extended Trumpet Illuminator |
| US20160310323A1 (en) * | 2015-04-24 | 2016-10-27 | Katalyst Surgical, Llc | Steerable laser probe and methods of use |
| CN116392727A (en) * | 2023-04-23 | 2023-07-07 | 张晨 | Implantable Fiber Optic Devices |
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