CN117398216A - Multipurpose gas generating, quantitative conveying and metering device and application thereof - Google Patents
Multipurpose gas generating, quantitative conveying and metering device and application thereof Download PDFInfo
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- CN117398216A CN117398216A CN202311561216.0A CN202311561216A CN117398216A CN 117398216 A CN117398216 A CN 117398216A CN 202311561216 A CN202311561216 A CN 202311561216A CN 117398216 A CN117398216 A CN 117398216A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/10—Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces
- B01D46/12—Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces in multiple arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
- G01F1/05—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects
- G01F1/34—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
- G01P5/00—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft
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- Animal Behavior & Ethology (AREA)
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Abstract
The invention discloses a multipurpose gas generating, quantitative conveying and metering device and application thereof. The invention has a multi-purpose new infectious disease pathogen transmission path identification device for identifying whether the new infectious disease pathogen is transmitted through air transmission, environmental object surface contact transmission or direct contact transmission; animal dosing, immunization device (via air route); the development device of the air pollution/poisoning animal model generates a pollution model (such as a CO/pollutant poisoning model) by setting air to quantitatively and regularly CO-feed specific substances; an air hypoxia/drunk model construction device (setting air hypoxia, oxygen enrichment, or a change of a certain air composition); poisoning biological oxygen supply recovery model devices (such as CO poisoning recovery, chlorine poisoning, etc.); nebulization therapy model means (mouse cough response nebulization therapy model); high-efficient filter screen filter effect evaluation device.
Description
Technical Field
The invention relates to the technical field of medical tests, in particular to a multipurpose gas generating, quantitative conveying and metering device and application thereof.
Background
In recent decades, worldwide human witnessed an unclear outbreak and prevalence of new infectious diseases, such as ebola, zhai ka, monkey pox, new crown, fever with thrombocytopenia syndrome; there are also many infectious diseases, which are re-developed by changing the traditional transmission way due to drug resistance enhancement, genetic evolution, co-infection, etc., such as monkey pox, phthisis, and hepatitis C epidemic, etc., which cause serious threat and profound influence on global public health and social economy. Over 80% of outbreaks of new infectious diseases have been caused by zoonotic or vector-transmitted pathogens in the past 70 years, wherein wild animals are important hosts of many zoonotic pathogens, and part of vector organisms can also be used as transmission vectors of some new infectious diseases, and mice, hedgehog, shrew, ticks and the like are transmission vectors and preservation hosts of many new infectious diseases. In the initial stage of epidemic situation occurrence, human beings have insufficient knowledge of pathogens of some new infectious diseases, have unclear knowledge of transmission ways, are difficult to accurately and effectively prevent and control measures, and are easy to cause epidemic situation transmission and spread; therefore, a device is needed that can quickly determine the way and manner of infection of a newly developed infectious disease.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides a multipurpose gas generating, quantitative conveying and metering device and application thereof.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the multipurpose gas generating, quantitative conveying and metering device comprises a test tube, wherein the input end of the test tube is provided with a generator, and the output end of the test tube is respectively connected with an airflow impact absorption bottle and a negative pressure flow meter through an exhaust tube b;
the test tube is sequentially provided with an airflow check valve a, a filter screen b, an animal chamber a, an airflow check valve b, an animal chamber b and a filter screen a from an input end to an output end, an air inlet pipe b and an air speed monitor b are respectively arranged between the filter screen b and the animal chamber a, an air inlet pipe a and an air speed monitor a are respectively arranged between the airflow check valve b and the animal chamber b, and the animal chamber a and the airflow check valve b are connected with an airflow impact absorption bottle through an exhaust tube a.
Preferably, the two ends of the animal room a are respectively provided with the wire netting c and the wire netting d, and the two ends of the animal room b are respectively provided with the wire netting a and the wire netting b.
Preferably, the ultraviolet lamp is arranged on both sides of the filter screen b and the airflow check valve b.
Preferably, the air inlet pipe a, the air inlet pipe b, the air exhaust pipe a and the air exhaust pipe b are all provided with control valves.
Preferably, the generator comprises an aerosol generator, an atomizer and a contaminant particle generator.
Preferably, both the filter screen a and the filter screen b are rotatable.
A multipurpose gas generating, metering and metering device use, comprising in particular:
application 1: identification of a new infectious disease pathogen transmission pathway;
application 2: dosing and immunization of animals;
and 3: constructing an air pollution and poisoning animal model;
application 4: constructing an air hypoxia and drunk oxygen model;
use 5: building an oxygen supply recovery model of poisoning organisms;
application 6: constructing an atomization treatment model;
application 7: and (5) evaluating the filtering effect of the filter screen.
Preferably, in use, the air flow check valve b is closed and the animal chamber a is placed in an infected animal; the air flows in from the air flow check valve a, passes through the filter screen b and the wire gauze c, reaches the animal chamber a, continuously moves forward through the exhaust pipe a to reach the air flow impact absorption bottle, and detects whether the liquid in the bottle contains pathogens.
Compared with the prior art, the invention has the beneficial effects that: the invention has the following functions and advantages:
1. a new infectious disease pathogen transmission path identification device for identifying whether the new infectious disease pathogen is transmitted through air transmission, environmental object surface contact transmission or direct contact transmission;
2. animal dosing, immunization device (via air route);
3. the development device of the air pollution/poisoning animal model generates a pollution model (such as a CO/pollutant poisoning model) by setting air to quantitatively and regularly CO-feed specific substances;
4. an air hypoxia/drunk model construction device (setting air hypoxia, oxygen enrichment, or a change of a certain air composition);
5. poisoning biological oxygen supply recovery model devices (such as CO poisoning recovery, chlorine poisoning, etc.);
6. nebulization therapy model means (mouse cough response nebulization therapy model);
7. high-efficient filter screen filter effect evaluation device.
Drawings
In order to more particularly and intuitively illustrate an embodiment of the present invention or a technical solution in the prior art, a brief description of the drawings is provided below, which are required to be used in the description of the embodiment or the prior art.
FIG. 1 is a schematic diagram of a multipurpose gas generating, metering and metering apparatus;
FIG. 2 is a schematic diagram of a multipurpose gas generating, metering and metering device for identifying the path of transmission of a pathogen of a new infectious disease.
In the figure: the air flow check valve a1, the ultraviolet lamp 2, the air inlet pipe a3, the animal chamber a4, the wind speed monitor a5, the wire netting a6, the wire netting b7, the test tube 8, the filter net a9, the negative pressure flow meter 10, the generator 11, the filter net b12, the air inlet pipe b13, the wind speed monitor b14, the wire netting c15, the wire netting d16, the air flow check valve b17, the animal chamber b18, the exhaust tube a19, the air flow impact absorbing bottle 20 and the exhaust tube b21.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments.
Referring to fig. 1, a multipurpose gas generating, quantitative conveying and metering device comprises a test tube 8, wherein the input end of the test tube 8 is provided with a generator 11, and the output end is respectively connected with a gas flow impact absorption bottle 20 and a negative pressure flow meter 10 through a suction tube b 21;
the test tube 8 is sequentially provided with an airflow check valve a1, a filter screen b12, an animal chamber a4, an airflow check valve b17, an animal chamber b18 and a filter screen a9 from the input end to the output end, an air inlet pipe b13 and an air speed monitor b14 are respectively arranged between the filter screen b12 and the animal chamber a4, an air inlet pipe a3 and an air speed monitor a5 are respectively arranged between the airflow check valve b17 and the animal chamber b18, and the animal chamber a4 and the airflow check valve b17 are connected with an airflow impact absorption bottle 20 through an exhaust pipe a 19.
In this embodiment, the wire netting c15 and the wire netting d16 are installed respectively at the both ends of animal room a4, and the wire netting a6 and the wire netting b7 are installed respectively at the both ends of animal room b18 for the protection avoids the animal to float in experimental pipe 8.
In this embodiment, the ultraviolet lamp 2 is installed on both sides of the filter screen b12 and the airflow check valve b17 for ultraviolet sterilization, and the control valves are installed on the air inlet pipe a3, the air inlet pipe b13, the air exhaust pipe a19 and the air exhaust pipe b21, so as to control each pipeline.
In this embodiment, the generator 11 includes an aerosol generator, an atomizer, and a pollutant particle generator, which are selected according to actual needs.
In this embodiment, the filter screen a9 and the filter screen b12 are rotatable, and whether the filter screen a9 and the filter screen b12 are beneficial to the selection can be performed according to actual needs, and the filter screen a9 and the filter screen b12 are rotated to be parallel to the airflow, so that the filter screen a9 and the filter screen b12 cannot play a role in filtration.
A multipurpose gas generating, metering and metering device use, comprising in particular:
application 1: identification of a new infectious disease pathogen transmission pathway;
application 2: dosing and immunization of animals;
and 3: constructing an air pollution and poisoning animal model;
application 4: constructing an air hypoxia and drunk oxygen model;
use 5: building an oxygen supply recovery model of poisoning organisms;
application 6: constructing an atomization treatment model;
application 7: and (5) evaluating the filtering effect of the filter screen.
As shown in fig. 2, in the use 1, the air flow check valve b17 is closed, and the animal chamber a4 is infected with an animal; air flows in from the air flow check valve a1, passes through the filter screen b12 and the wire gauze c15, reaches the animal chamber a4, and continuously passes through the exhaust pipe a19 to reach the air flow impact absorption bottle 20, and whether the liquid in the bottle contains pathogens or not is detected.
If the animal is negative, the air is excluded from spreading, the air flow check valve b17 is continuously closed, the infected animal in the animal chamber a4 is taken out, the air flow fully flows, the uninfected animal is put into the animal chamber a4, the infection condition of the small animal is detected after the longest incubation period, the animal can be spread through environmental contact, otherwise, the animal can not be spread through environmental contact, the uninfected animal and the infected animal are put into the animal chamber a4 at the same time, the infection condition of the uninfected animal is detected after the long incubation period, and the animal can be spread through contact.
If positive, the pathogen may spread via air.
And continuously closing the airflow check valve b17, taking out the animal chamber a4 to infect the animal, allowing the airflow to flow fully, putting the uninfected animal into the animal chamber a4, detecting the infection condition of the small animal after the longest incubation period, wherein the infection condition of the small animal is positive, and the infection condition can be transmitted through environmental contact, otherwise, the infection condition of the small animal is negative, and the infection condition can not be transmitted through the environmental contact.
Closing the air extraction pipe a19, opening the air flow one-way valve b17, continuing to move forward from the animal chamber a4 to pass through the animal chamber b18, enabling the air to reach the air flow impact absorption bottle 20 through the air extraction pipe b21, and detecting the infection condition of the animal in the animal chamber b18 through a longest incubation period, wherein if the air flow impact absorption bottle is positive, the air can be transmitted through the air, and the air flow impact absorption bottle 20 can be detected to verify the effect of the high-efficiency filter screen, otherwise, if the air flow impact absorption bottle is negative, the air cannot be transmitted through the air.
In the application 2, animal dosing and immunization, the animal dosing monitors the absorption amount of the medicine by monitoring the residual air dosage of the air flow impacting the absorption bottle 20, and the device can accurately, rapidly, quantitatively and regularly dose; in the process of administration, the administration dosage can be conveniently monitored.
Immunization animals immunized by inhalation method are placed in an animal room a4, and an aerosol generator generates vaccine aerosol at fixed time and fixed quantity according to the requirement; after inoculation is finished, the aerosol generator is closed, the air valve is opened, vaccine in the pipeline environment is replaced, the respiratory tract infection path is simulated, and the vaccine is inhaled to generate antibodies.
In the application 3, PM2.5 or other pollutant particle generators are placed at the position of the generator 11, gas with corresponding particle concentration is generated at fixed time, fixed quantity and fixed concentration, the gas is released into the device, after the suction time is reached, the particle generators are removed, the clean air generator is connected, and the atmospheric dust haze fine particles (airborne fine particulate matter, PM 2.5) refer to fine particles with the diameter equal to or smaller than 2.5um in the total suspended particles in the atmosphere, and the fine particles are derived from artificial or natural pollution sources and have complex and variable components. The existing animal model is built by a one-time, short-time and large-concentration exposure method, the whole pathological occurrence and development process of the long-term chronic disease of PM2.5 damage to the organism is difficult to dynamically and systematically observe, the standard animal model of PM2.5 damage to the organism is not seen at home and abroad before, the lack of a stable animal model becomes the bottleneck problem of PM2.5 damage organism research, and the research and application of prevention measures are limited. Therefore, a proper animal model and a research method are established, objective and accurate research means can be provided for evaluating PM2.5 damage organism research, and a new idea is provided for research of a research mechanism. The device aims at the core problems of 3 infection duration of (1) infection approaches (2) infection concentration (3) and constructs an animal injury model. Other contaminants in the atmosphere such as CO, SO2, etc. can also be modeled by this device.
In the application 4, PM2.5 or other pollutant particle generators are placed at the position of the generator 11, gas with corresponding particle concentration is generated at fixed time, fixed quantity and fixed concentration, the gas is released into the device, after the inhalation time is reached, the particle generators are removed, the clean air generator is connected, and the oxygen concentration in the closed space is reduced to cause the animal to inhale the animal model with insufficient oxygen to cause the hypoxia injury of the animal. The animal hyperbaric oxygen chamber is a special experimental oxygen chamber designed for experimental animals, and can be used for the study of hypobaric oxygen and hyperbaric oxygen simultaneously. The method has two manual and automatic operation modes, and can be used for simulating the plateau environment and manufacturing animal models such as cerebral edema, pulmonary arterial hypertension and the like.
In the application 5, the air flow check valve a1, the air inlet pipe b13, the air flow check valve b17 and the air exhaust pipe a19 are closed, the device is used for simulating that oxygen is firstly supplied and then supplied, the time of the cell oxygen-deficient reoxygenation model is required to be determined according to experimental conditions, and generally, the time of the cell oxygen-deficient reoxygenation model is required to be at least 30 minutes. Within this 30 minutes, the cells are in an anoxic state, during which the cells are subjected to a lack of oxygen, resulting in reduced activity within the cells and an affected metabolic level of the cells. Then, the cells will recover to normal oxygen state, and the activity and metabolism level of the cells will recover to normal, thereby completing the experiment of the hypoxia reoxygenation model of the cells.
In use 6, an atomization treatment model is built, an atomizer is placed at the generator 11, animals in the animal chambers a4 and b18 are atomized, and cough or tracheal/bronchial constriction reactions of humans can sometimes cause hypoxia, even asphyxia, such as asthma, in a short time; respiratory diseases such as bronchiectasis also in need of nebulization treatment; the atomized administration is characterized by small fogdrops, deep into the airway, quick absorption and better treatment effect.
In application 7, the filter screen filter effect evaluation is performed by placing the device in a biosafety cabinet, placing pathogenic microorganisms to be filtered in a culture medium or deionized water, releasing aerosol containing the pathogenic microorganisms according to a preset concentration, particle size and time by an aerosol generator, monitoring the pathogenic microorganisms in an airflow impact absorption bottle 20 by a PCR/RT-PCR method, monitoring the filter effect of a high-efficiency filter, and various high-efficiency filters are provided, wherein the high-efficiency filter has an activated carbon filter and a non-woven filter according to different filter materials. The high-efficiency filter is widely applied to industries such as medicine, biology, food, electronics and the like because of the high-efficiency filtering performance, mainly filters particles which cannot be seen by naked eyes in air and bacteria which cause harm to health, and has a filtering effect far higher than that of a common filtering material. As is well known, many of the airborne dust is invisible to the naked eye, and the fine dust enters the lungs by breathing and can cause some injury to the human body over time. Moreover, if the machine equipment of the factory is operated for a long time, dust is covered, so that not only the service performance is affected, but also the abrasion is accelerated, and the service life is affected. The high-efficiency filter has quite good filtering performance due to the large dust containing area of the high-efficiency filter. Typically, high efficiency filters require one cleaning for one to two months of use.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.
Claims (8)
1. The multipurpose gas generating, quantitative conveying and metering device comprises a test tube (8), and is characterized in that the input end of the test tube (8) is provided with a generator (11), and the output end of the test tube is respectively connected with an airflow impact absorption bottle (20) and a negative pressure flowmeter (10) through an exhaust tube b (21);
the test tube (8) is sequentially provided with an airflow check valve a (1), a filter screen b (12), an animal chamber a (4), an airflow check valve b (17), an animal chamber b (18) and a filter screen a (9) from an input end to an output end, an air inlet pipe b (13) and an air speed monitor b (14) are respectively arranged between the filter screen b (12) and the animal chamber a (4), an air inlet pipe a (3) and an air speed monitor a (5) are respectively arranged between the airflow check valve b (17) and the animal chamber b (18), and the animal chamber a (4) and the airflow check valve b (17) are connected with an airflow impact absorption bottle (20) through an exhaust pipe a (19).
2. The multipurpose gas generating, quantitative conveying and metering device according to claim 1, wherein the wire netting c (15) and the wire netting d (16) are respectively installed at two ends of the animal chamber a (4), and the wire netting a (6) and the wire netting b (7) are respectively installed at two ends of the animal chamber b (18).
3. The multipurpose gas generating, quantitative conveying and metering device according to claim 2, wherein the ultraviolet lamp (2) is installed on both sides of the filter screen b (12) and the airflow check valve b (17).
4. A multipurpose gas generating, quantitative delivering and metering device according to claim 3, wherein control valves are installed on the gas inlet pipe a (3), the gas inlet pipe b (13), the gas exhaust pipe a (19) and the gas exhaust pipe b (21).
5. A multipurpose gas generating, metering device as claimed in claim 4, characterized in that said generator (11) comprises an aerosol generator, an atomizer and a pollutant particle generator.
6. A multipurpose gas generating, metering device as claimed in claim 5, wherein both the filter screen a (9) and the filter screen b (12) are rotatable.
7. Use of a multipurpose gas generating, metering and dosing device according to any of claims 1 to 6, characterized in that it comprises in particular:
application 1: identification of a new infectious disease pathogen transmission pathway;
application 2: dosing and immunization of animals;
and 3: constructing an air pollution and poisoning animal model;
application 4: constructing an air hypoxia and drunk oxygen model;
use 5: building an oxygen supply recovery model of poisoning organisms;
application 6: constructing an atomization treatment model;
application 7: and (5) evaluating the filtering effect of the filter screen.
8. Use of a multipurpose gas generating, metering and metering device according to claim 7, characterized in that in use (1) the air flow check valve b (17) is closed and the animal chamber a (4) is placed in infected animals; air flows in from the air flow check valve a (1), passes through the filter screen b (12) and the wire gauze c (15) and reaches the animal chamber a (4), and the air flow continuously passes through the exhaust pipe a (19) and reaches the air flow impact absorption bottle (20) to detect whether the liquid in the bottle contains pathogens or not.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311561216.0A CN117398216A (en) | 2023-11-21 | 2023-11-21 | Multipurpose gas generating, quantitative conveying and metering device and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311561216.0A CN117398216A (en) | 2023-11-21 | 2023-11-21 | Multipurpose gas generating, quantitative conveying and metering device and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117398216A true CN117398216A (en) | 2024-01-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311561216.0A Pending CN117398216A (en) | 2023-11-21 | 2023-11-21 | Multipurpose gas generating, quantitative conveying and metering device and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117398216A (en) |
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2023
- 2023-11-21 CN CN202311561216.0A patent/CN117398216A/en active Pending
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