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CN117050725B - Radiation blocking and sterilizing dual-function complexing agent and preparation method and application thereof - Google Patents

Radiation blocking and sterilizing dual-function complexing agent and preparation method and application thereof Download PDF

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CN117050725B
CN117050725B CN202310925538.2A CN202310925538A CN117050725B CN 117050725 B CN117050725 B CN 117050725B CN 202310925538 A CN202310925538 A CN 202310925538A CN 117050725 B CN117050725 B CN 117050725B
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composite agent
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CN117050725A (en
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刘利达
孙松美
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Shandong Hengyi High Tech Industry Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F1/00—Shielding characterised by the composition of the materials
    • G21F1/02—Selection of uniform shielding materials
    • G21F1/10—Organic substances; Dispersions in organic carriers

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
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  • High Energy & Nuclear Physics (AREA)
  • Materials Engineering (AREA)
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  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

The invention belongs to the technical field of radiation protection and disinfection and sterilization, and in particular relates to a radiation blocking and sterilization dual-function complexing agent, a preparation method and application thereof. The radiation blocking and sterilizing dual-function complexing agent at least comprises a neutron protective compound, a nuclear radiation protective compound and a sterilizing compound, and the complexing agent is a liquid preparation. The invention provides a radiation blocking and sterilizing dual-function complexing agent for the first time, which can be used for air spray purification or wet towel impregnating solution and the like, thereby playing roles in removing radiation dust, aerosol in the air, erasing nuclear pollution operation table, doors and windows of hospital wards and the like and nuclear pollution areas dust, and meanwhile, sterilizing components in the complexing agent can play multiple roles in killing bacteria, viruses, preventing corrosion and the like, and can be applied to various nuclear facility environments and scenes, so that the complexing agent has good practical application value.

Description

Radiation blocking and sterilizing dual-function complexing agent and preparation method and application thereof
Technical Field
The invention belongs to the technical field of radiation protection and sterilization, and particularly relates to a radiation blocking and sterilization dual-function complexing agent, a preparation method and application thereof.
Background
The information disclosed in the background of the invention is only for enhancement of understanding of the general background of the invention and is not necessarily to be taken as an admission or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.
There are a large number of radioactive dust, aerosols, etc. in the radiology department environment of medical institutions. Compared with medical imaging departments and radiotherapy departments, the radiation dose monitoring data of the nuclear medicine department radiological staff is 4-10 times of that of other departments, and related researches on nuclear medicine workplace nuclear protection products are needed to be carried out. Besides the harm of radioactive dust, aerosol and the like, the radiation medical working environment and other places of a hospital need to be sterilized and disinfected regularly, so that the development of products with sterilization and nuclear radiation prevention functions in the radiation medical working environment has higher scientific research value and higher practical application value.
The radioactive materials in the radiology department environment mainly comprise beta rays (99%) and gamma rays (1%) emitted by medical nuclides such as iodine 131 (I-131), technetium 99 (Tc-99), fluorine 18 (18-F) and the like. In addition to nuclear contamination with radiopharmaceuticals, neutrons generated when radioisotopes are prepared in hospitals using cyclotrons are another major source of radiation contamination. Thus, hospital nuclear radiation protection products need to be protected from both neutrons and radiation.
The inventor researches find that boron 10 is the most commonly used element with the least toxicity at present, but no report on the compound of boron 10 is available for researching the compound of other chemical elements, boron 10 and bactericides based on the compound of boron 10, and the most commonly used radiation protection element is lead at present. However, lead element can only be added as a solid sample in nuclear radiation-proof products, and liquid products such as lead element can cause serious harm to the surrounding environment and human body, and nontoxic or low-toxicity substitute elements must be searched. Therefore, how to configure a liquid nuclear radiation protection product and have a sterilizing function at the same time is still a technical problem to be solved in the art.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a radiation blocking and sterilizing dual-function complexing agent, a preparation method and application thereof, so that the dual-function complexing agent can be used as a wet towel impregnating solution and an air spraying liquid raw material for removing nuclear radiation dust, aerosol, bacteria, viruses and the like on the air and object surfaces in a nuclear polluted environment. Based on the above results, the present invention has been completed.
In order to achieve the technical purpose, the technical scheme provided by the invention is as follows:
In a first aspect, the invention provides a radiation blocking and sterilizing dual-function complexing agent, which at least comprises a neutron shielding compound, a nuclear radiation shielding compound and a sterilizing compound, wherein the complexing agent is a liquid preparation;
the neutron shielding compound is boron 10 acid or a nontoxic compound containing boron 10 element, and further can be boric acid.
The nuclear radioprotective compound is selected from non-toxic or low-toxic soluble compounds containing elements including but not limited to bismuth, tungsten, tantalum, lanthanum, cerium, and further selected from any one or more of potassium bismuth citrate, ammonium bismuth citrate, sodium tungstate, sodium tantalate, lanthanum chloride, and cerium chloride.
The bactericidal compound is selected from any one or more of sodium benzoate, benzalkonium chloride, chlorhexidine gluconate, benzethonium chloride and benzalkonium bromide.
In a second aspect of the present invention, there is provided a method for preparing the above-mentioned radiation blocking and sterilizing bifunctional complexing agent, the method comprising:
s1, dispersing the neutron shielding compound into water, adding a stabilizer, and stirring to obtain a solution A;
s2, adding the nuclear ray protection compound into the solution A prepared in the step S1, and stirring and dissolving by ultrasonic to obtain a solution B;
And S3, adding the bactericidal compound into the solution B and stirring to obtain the bactericidal compound.
In a third aspect, the present invention provides the use of the above-described radiation blocking and disinfecting dual-function complexing agent for preparing a disinfecting nuclear radiation resistant product.
The beneficial technical effects of one or more of the technical schemes are as follows:
The technical scheme provides a radiation blocking and sterilizing dual-function complexing agent product for the first time, the product can be used for air spray purification or wet towel impregnating solution, plays roles in removing radiation dust and aerosol in air, erasing nuclear pollution areas such as a nuclear pollution operation table, doors and windows of hospital wards and the like, and meanwhile, sterilizing components in the complexing agent can play multiple roles in killing bacteria, viruses, preventing corrosion and the like, and can be applied to various nuclear facility environments and scenes, so that the complexing agent has good practical application value.
Detailed Description
It should be noted that the following detailed description is illustrative and is intended to provide further explanation of the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present invention. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.
The invention will now be further illustrated with reference to specific examples, which are given for the purpose of illustration only and are not intended to be limiting in any way. The reagents, consumables, etc. used in the examples described below are commercially available unless otherwise specified, and are usually used under conventional conditions or under conditions recommended by the reagent company.
In one exemplary embodiment of the present invention, a dual radiation blocking and sterilization functional complexing agent is provided, the complexing agent comprising at least a neutron shielding compound, a nuclear radiation shielding compound, and a sterilization compound, the complexing agent being a liquid formulation.
The neutron protecting compound is boron 10 acid or a nontoxic compound containing boron 10 element, and further, as the abundance of boron-10 and boron-11 in the natural boron element is 19.78% and 80.22%, respectively, high-dose natural boron element can be adopted to replace boron-10 as a neutron protecting material, and therefore, the neutron protecting compound can also be boric acid.
The nuclear radioprotective compound is selected from non-toxic or low-toxic soluble compounds containing elements including but not limited to bismuth, tungsten, tantalum, lanthanum, cerium, and further selected from any one or more of potassium bismuth citrate, ammonium bismuth citrate, sodium tungstate, sodium tantalate, lanthanum chloride, and cerium chloride.
The bactericidal compound is selected from any one or more of sodium benzoate, benzalkonium chloride, chlorhexidine gluconate, benzethonium chloride and benzalkonium bromide.
When the nuclear radiation protective compound is selected from soluble bismuth-containing compounds, the bactericidal compound may be selected from sodium benzoate, but ammonium and amino-containing bactericides (such as benzalkonium chloride, benzethonium chloride, benzalkonium bromide, etc.) are not suitable because the compounding thereof is prone to cause precipitation problems, and the problem of analyzing the formation of precipitates of ammonium bactericides is that ammonium or amine groups ionize in water to form weakly basic hydroxide ions, which react with soluble bismuth-containing compounds (such as bismuth potassium citrate) to cause precipitation of bismuth, so that ammonium and amino-containing bactericides are not suitable.
Wherein the mass ratio of the neutron shielding compound to the nuclear radiation shielding compound to the bactericidal compound is 0.5-10:0.05-100:0.01-0.5, and further is 0.5-5:0.05-1:0.01-0.2.
The solvent of the complexing agent is water, and further deionized water.
In another specific embodiment of the present invention, the dual function radiation blocking and sterilizing compound may further contain a common auxiliary material component such as a stabilizer, wherein the stabilizer may be ethylene glycol, and the stabilizer may effectively improve the stability of the active ingredient. The content of the glycol in the complexing agent is 0.1-1% (w/w).
In still another embodiment of the present invention, there is provided a method for preparing the above-mentioned radiation blocking and sterilizing bifunctional complexing agent, the method comprising:
s1, dispersing the neutron shielding compound into water, adding a stabilizer, and stirring to obtain a solution A;
s2, adding the nuclear ray protection compound into the solution A prepared in the step S1, and stirring and dissolving by ultrasonic to obtain a solution B;
And S3, adding the bactericidal compound into the solution B and stirring to obtain the bactericidal compound.
In the step S1, the mass ratio of the neutron shielding compound to water is 1:5-1000, further 1:10-100, and the water is deionized water.
The stabilizer may be ethylene glycol.
In yet another embodiment of the present invention, there is provided the use of the above-described radiation blocking and disinfecting dual-function complexing agent for preparing a disinfecting nuclear radiation resistant product.
The sterilization and nuclear radiation protection product can be any product containing the complexing agent, such as air spraying, wet tissues, devices, equipment, systems (such as a sprayer) and the like carrying the complexing agent, and is not particularly limited herein, and meanwhile, the sterilization and nuclear radiation protection product can be applied to any nuclear pollution environment, particularly environments with pollutants such as radioactive dust, aerosol, bacterial virus and the like, including but not limited to medical institutions, scientific research institutions, nuclear power stations and the like with radioactive sources (such as corresponding nuclear devices and equipment).
The invention is further illustrated by the following examples, which are not to be construed as limiting the invention. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention. The following examples are test methods in which specific conditions are noted, and are generally conducted under conventional conditions.
Example 1
To 100mL of deionized water, 0.2g of bismuth potassium citrate was added, and the solution was stirred and dissolved, and to this solution, 2g of boric acid was further added, and stirring and dissolution were carried out, to obtain a clear and transparent solution, 0.8g of ethylene glycol was added, and 0.05g of benzethonium chloride was added, and dispersed under stirring. A large amount of white precipitate is found to be generated in the stirring and dissolving process, which indicates that the stable sterilizing and nuclear radiation preventing dual-function compound preparation cannot be obtained by compounding bismuth potassium citrate, boric acid, ethylene glycol and benzethonium chloride.
Example 2
To 100mL of deionized water, 0.2g of bismuth potassium citrate was added, and the solution was stirred and dissolved, and to this solution, 2g of boric acid was further added, and stirring and dissolution were continued, to obtain a clear and transparent solution, and 0.8g of ethylene glycol was added, and 0.05g of chlorhexidine gluconate was added, and dispersed under stirring. A large amount of white precipitate is found to be generated in the stirring and dissolving process, which indicates that the stable sterilizing and nuclear radiation preventing dual-function compound preparation cannot be obtained by compounding bismuth potassium citrate, boric acid, ethylene glycol and chlorhexidine gluconate.
Example 3
To 100mL of deionized water, 0.2g of bismuth potassium citrate was added, and the solution was stirred and dissolved, and to this solution, 2g of boric acid was further added, and stirring and dissolution were carried out, to obtain a clear and transparent solution, 0.8g of ethylene glycol was added, and 0.05g of benzalkonium chloride was added, and the solution was dispersed under stirring. A large amount of white precipitate is found to be generated in the stirring and dissolving process, which indicates that the stable sterilizing and nuclear radiation preventing dual-function compound preparation cannot be obtained by compounding bismuth potassium citrate, boric acid, ethylene glycol and benzalkonium chloride.
Example 4
To 100mL of deionized water, 0.2g of bismuth potassium citrate was added, and the solution was stirred and dissolved, and to this solution, 2g of boric acid was further added, and stirring and dissolution were carried out, to obtain a clear and transparent solution, 0.8g of ethylene glycol was added, and 0.05g of benzalkonium bromide was added, and dispersed under stirring. A large amount of white precipitate is found to be generated in the stirring and dissolving process, which indicates that the stable sterilizing and nuclear radiation preventing dual-function compound preparation cannot be obtained by compounding bismuth potassium citrate, boric acid, ethylene glycol and benzalkonium bromide.
Based on the problems that ammonium and amino-containing bactericides are compounded with bismuth potassium citrate, boric acid and ethylene glycol to generate precipitation, the problem of analysis of the formation of the precipitation of the ammonium bactericides is that ammonium or amino groups are ionized in water to generate weak alkaline hydroxide ions, and the weak alkaline hydroxide ions react with bismuth potassium citrate to cause bismuth to separate out, so that the implementation scheme is further adjusted by adjusting the bactericides.
Example 5
Adding 0.2g of bismuth potassium citrate into 100mL of deionized water, stirring for dissolution, continuously adding 2g of boric acid into the solution, stirring for dissolution to obtain a clear and transparent solution, adding 0.8g of ethylene glycol for stirring for dispersion, adding 0.04g of sodium benzoate, and stirring for dissolution to obtain the clear and transparent solution. The bismuth potassium citrate, boric acid, ethylene glycol and sodium benzoate are compounded to obtain the stable sterilizing and nuclear radiation preventing dual-function compound preparation. A piece of non-woven fabric of 18cm multiplied by 21cm is immersed in 5mL of the preparation to prepare a wet towel, the wet towel is used for wiping a stainless steel tabletop exposed in a 131 I environment with an activity concentration of 3000Bq/m 3 for 1m 2, the activity concentration of 131 I on the tabletop before and after wiping is tested, the removal rate of 131 I is found to be 99.7%, escherichia coli is cultured on the surface of the similar stainless steel, and the removal rate of the wet towel to escherichia coli can reach 99.5%.
Example 5 illustrates that the bactericidal and nuclear radiation-proof dual-function composite preparation obtained by compounding bismuth potassium citrate, boric acid, ethylene glycol and sodium benzoate has good performance.
To further explore the feasibility of using other ingredients in combination with a nuclear radiation protective element to obtain a dual-function composite formulation for sterilization and nuclear radiation protection, we further replaced bismuth potassium citrate with sodium tungstate to obtain the following examples.
Example 6
Adding 0.3g of sodium tungstate into 100mL of deionized water, stirring for dissolution, continuously adding 2g of boric acid into the solution, stirring for dissolution to obtain a clear and transparent solution, adding 0.8g of ethylene glycol for stirring for dispersion, adding 0.05g of benzethonium chloride, and stirring for dissolution to obtain the clear and transparent solution. The sodium tungstate, boric acid, glycol and benzethonium chloride are compounded to obtain the stable bactericidal and nuclear radiation-proof dual-function composite preparation. A piece of non-woven fabric of 18cm multiplied by 21cm is immersed in 5mL of the compound preparation to prepare a wet towel, the wet towel is used for wiping a stainless steel tabletop exposed in a 131 I environment with an activity concentration of 3000Bq/m 3 for 1m 2, the activity concentration of 131 I on the tabletop before and after wiping is tested, the removal rate of 131 I is found to be 95%, escherichia coli is cultured on the surface of the similar stainless steel, and the removal rate of the wet towel to escherichia coli can reach 99.9%.
Example 7
Example 7 differs from example 6 in that 0.05g of benzethonium chloride was replaced by 0.05g of chlorhexidine gluconate and a clear, transparent solution was obtained after stirring to dissolve. The sodium tungstate, boric acid, glycol and benzethonium chloride are compounded to obtain the stable bactericidal and nuclear radiation-proof dual-function composite preparation. A piece of non-woven fabric of 18cm multiplied by 21cm is immersed in 5mL of the compound preparation to prepare a wet tissue, the wet tissue is used for wiping a stainless steel tabletop exposed in a 131 I environment with an activity concentration of 3000Bq/m 3 to obtain a 1m 2 activity concentration of 131 I on the tabletop before and after wiping, the removal rate of 131 I is found to be 94%, escherichia coli is cultured on the surface of the similar stainless steel, and the removal rate of the wet tissue to escherichia coli can reach 99.5%.
Example 8
Example 8 differs from example 6 in that 0.05g of benzethonium chloride was replaced by 0.04g of sodium benzoate, and a clear and transparent solution was obtained after stirring to dissolve. The sodium tungstate, boric acid, glycol and sodium benzoate are compounded to obtain the stable dual-functional composite preparation for sterilization and nuclear radiation prevention. A piece of non-woven fabric of 18cm multiplied by 21cm is immersed in 5mL of the compound preparation to prepare a wet towel, the wet towel is used for wiping a stainless steel tabletop exposed in a 131 I environment with an activity concentration of 3000Bq/m 3 for 1m 2, the activity concentration of 131 I on the tabletop before and after wiping is tested, the removal rate of 131 I is found to be 95%, escherichia coli is cultured on the surface of the similar stainless steel, and the removal rate of the wet towel to escherichia coli can reach 99.4%.
Examples 6-8 illustrate that the dual-function composite preparation for sterilization and nuclear radiation prevention can be obtained by compounding sodium tungstate, boric acid, ethylene glycol and an ammonium disinfectant or a sodium benzoate or chlorhexidine type sterilization disinfectant.
Example 9
Example 9 differs from example 6 in that 0.3g of sodium tungstate was replaced by 0.3g of sodium tantalate, the remaining compounds being identical, and a clear transparent solution was obtained after stirring to dissolve. The sodium tantalate, boric acid, glycol and benzethonium chloride are compounded to obtain the stable bactericidal and nuclear radiation-proof dual-function composite preparation. A piece of non-woven fabric of 18cm multiplied by 21cm is immersed in 5mL of the compound preparation to prepare a wet towel, the wet towel is used for wiping a stainless steel tabletop exposed in a 131 I environment with an activity concentration of 3000Bq/m 3 for 1m 2, the activity concentration of 131 I on the tabletop before and after wiping is tested, the removal rate of 131 I is found to be 90%, escherichia coli is cultured on the surface of the similar stainless steel, and the removal rate of the wet towel to escherichia coli can reach 99.9%.
Example 10
Example 10 differs from example 6 in that 0.3g of sodium tungstate was replaced by 0.5g of lanthanum chloride, the remaining compounds being identical, and a clear transparent solution was obtained after stirring to dissolve. The lanthanum chloride, boric acid, glycol and benzethonium chloride are compounded to obtain the stable sterilizing and nuclear radiation preventing dual-function compound preparation. A piece of non-woven fabric of 18cm multiplied by 21cm is immersed in 5mL of the compound preparation to prepare a wet towel, the wet towel is used for wiping a stainless steel tabletop exposed in a 131 I environment with an activity concentration of 3000Bq/m 3 for 1m 2, the activity concentration of 131 I on the tabletop before and after wiping is tested, the removal rate of 131 I is found to be 80%, escherichia coli is cultured on the surface of the similar stainless steel, and the removal rate of the wet towel to escherichia coli can reach 99.9%.
The invention is not a matter of the known technology.
The above embodiments are provided to illustrate the technical concept and features of the present invention and are intended to enable those skilled in the art to understand the content of the present invention and implement the same, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made in accordance with the spirit of the present invention should be construed to be included in the scope of the present invention.

Claims (13)

1.一种辐射阻断及杀菌双功能复合剂，其特征在于，所述复合剂至少包含中子防护化合物、核射线防护化合物以及杀菌化合物；所述复合剂为液体制剂；1. A radiation blocking and sterilization dual-function composite agent, characterized in that the composite agent at least comprises a neutron protection compound, a nuclear radiation protection compound and a sterilization compound; the composite agent is a liquid preparation; 其中，所述中子防护化合物为硼10酸或可溶性含硼10元素的无毒化合物；所述无毒化合物为硼酸；Wherein, the neutron protection compound is boric acid or a soluble non-toxic compound containing boron 10 element; the non-toxic compound is boric acid; 所述核射线防护化合物选自无毒或低毒的含有包括铋，钨，钽，镧，铈元素的可溶性化合物，可溶性化合物选自柠檬酸铋钾、柠檬酸铋铵、钨酸钠、钽酸钠、氯化镧和氯化铈中的任意一种或多种；The nuclear radiation protection compound is selected from non-toxic or low-toxic soluble compounds containing bismuth, tungsten, tantalum, lanthanum and cerium elements, and the soluble compound is selected from any one or more of potassium bismuth citrate, ammonium bismuth citrate, sodium tungstate, sodium tantalate, lanthanum chloride and cerium chloride; 当所述可溶性化合物选自柠檬酸铋钾、柠檬酸铋铵中的任意一种或多种时，所述杀菌化合物选自苯甲酸钠；When the soluble compound is selected from any one or more of potassium bismuth citrate and ammonium bismuth citrate, the bactericidal compound is selected from sodium benzoate; 当所述可溶性化合物选自钨酸钠、钽酸钠、氯化镧和氯化铈中的任意一种或多种时，所述杀菌化合物选自苯甲酸钠、苯扎氯铵、氯己定葡萄糖酸盐、苄索氯铵和苯扎溴铵中的任意一种或多种。When the soluble compound is selected from any one or more of sodium tungstate, sodium tantalate, lanthanum chloride and cerium chloride, the bactericidal compound is selected from any one or more of sodium benzoate, benzalkonium chloride, chlorhexidine gluconate, benzethonium chloride and benzalkonium bromide. 2.如权利要求1所述辐射阻断及杀菌双功能复合剂，其特征在于，所述中子防护化合物、核射线防护化合物以及杀菌化合物的质量比为0.5-10：0.05-100：0.01-0.5。2. The radiation blocking and sterilization dual-function composite agent according to claim 1, characterized in that the mass ratio of the neutron protection compound, the nuclear ray protection compound and the sterilization compound is 0.5-10:0.05-100:0.01-0.5. 3.如权利要求1所述辐射阻断及杀菌双功能复合剂，其特征在于，所述复合剂的溶剂为水。3. The radiation blocking and sterilization dual-function composite agent as claimed in claim 1, characterized in that the solvent of the composite agent is water. 4.如权利要求3所述辐射阻断及杀菌双功能复合剂，其特征在于，所述复合剂的溶剂为去离子水。4. The radiation blocking and sterilization dual-function composite agent as claimed in claim 3, characterized in that the solvent of the composite agent is deionized water. 5.如权利要求1所述辐射阻断及杀菌双功能复合剂，其特征在于，所述辐射阻断及杀菌双功能复合剂还含有稳定剂。5. The radiation blocking and sterilization dual-function composite agent as claimed in claim 1, characterized in that the radiation blocking and sterilization dual-function composite agent further contains a stabilizer. 6.如权利要求5所述的辐射阻断及杀菌双功能复合剂，其特征在于，所述稳定剂为乙二醇；所述乙二醇在复合剂中的含量为0.1-1％，w/w。6. The radiation blocking and sterilization dual-function composite agent according to claim 5, characterized in that the stabilizer is ethylene glycol; the content of the ethylene glycol in the composite agent is 0.1-1%, w/w. 7.权利要求1-6任一项所述辐射阻断及杀菌双功能复合剂的制备方法，其特征在于，所述制备方法包括：7. The method for preparing the radiation blocking and sterilization dual-function composite agent according to any one of claims 1 to 6, characterized in that the method comprises: S1、将所述中子防护化合物分散至水中，加入稳定剂搅拌得A液；S1. Dispersing the neutron protection compound into water, adding a stabilizer and stirring to obtain liquid A; S2、向步骤S1制得的A液中加入所述核射线防护化合物，超声搅拌溶解得B液；S2, adding the nuclear radiation protection compound to the solution A obtained in step S1, and dissolving by ultrasonic stirring to obtain solution B; S3、向B液中加入所述杀菌化合物搅拌后即得。S3, adding the bactericidal compound into liquid B and stirring to obtain the product. 8.如权利要求7所述的制备方法，其特征在于，所述步骤S1中，中子防护化合物与水的质量比为1：5-1000。8. The preparation method according to claim 7, characterized in that in step S1, the mass ratio of the neutron protection compound to water is 1:5-1000. 9.如权利要求8所述的制备方法，其特征在于，所述步骤S1中，中子防护化合物与水的质量比为1：10-100。9 . The preparation method according to claim 8 , characterized in that in step S1 , the mass ratio of the neutron protection compound to water is 1:10-100. 10.如权利要求8或9所述的制备方法，其特征在于，所述水为去离子水。10. The preparation method according to claim 8 or 9, characterized in that the water is deionized water. 11.如权利要求8或9所述的制备方法，其特征在于，所述稳定剂为乙二醇。11. The preparation method according to claim 8 or 9, characterized in that the stabilizer is ethylene glycol. 12.权利要求1-6任一项所述辐射阻断及杀菌双功能复合剂在制备杀菌防核辐射产品中的应用。12. Use of the radiation blocking and sterilization dual-function composite agent according to any one of claims 1 to 6 in the preparation of sterilization and nuclear radiation protection products. 13.如权利要求12所述的应用，其特征在于，所述杀菌防核辐射产品为含有所述复合剂的任意产品，包括空气喷雾、湿巾以及承载有所述复合剂的装置、设备和系统。13. The use according to claim 12, characterized in that the sterilization and nuclear radiation protection product is any product containing the compound, including air spray, wet wipes, and devices, equipment and systems carrying the compound.
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