CN116832725A - Material airtight circulation processing line - Google Patents

Abstract

The invention belongs to the technical field of material circulation equipment, and particularly relates to a material closed circulation treatment line, which comprises the following components: the opening of the charging barrel is provided with a first valve body which is used for sealing the opening; the material processing device, the first import department of material processing device is equipped with the second valve body, and the first exit of material processing device is equipped with the third valve body, and second valve body and third valve body are used for sealed material processing device, and second valve body and third valve body are used for dismantling with first valve body and be connected. According to the material airtight circulation processing line provided by the invention, when the equipment is required to be moved, the equipment can be conveniently disassembled, and meanwhile, the tightness of the equipment is maintained, so that the operability and the mobility of the equipment are improved.

Description

Material airtight circulation processing line

Technical Field

The invention relates to the technical field of material circulation equipment, in particular to a material closed circulation treatment line.

Background

In the pharmaceutical industry or the chemical industry, the production circulation of some materials may cause certain harm to human bodies, and also may cause pollution and damage to the environment; in addition, exposure of these materials to the environment may also be contaminated with contaminants in the environment, leading to the failure of the drug or chemical agent.

In the related art, materials are generally circulated in a closed environment, for example, the pharmaceutical industry generally uses occupational contact limit (occupational exposure limits, OEL for short) to reflect the level that workers do not cause acute or chronic health damage to the body during long-term repeated contact in the occupational activities, and generally, drugs are classified into five classes according to dangerous categories, namely, occupational exposure classification (Occupational Exposure Band, OEB for short), so as to define the closed measures required to be used by the related drug production equipment and the closed conditions to be achieved.

However, in the related art, after the drug production device meets the corresponding sealing condition, the device flexibility is poor, and the requirements of drug production on the operability and the mobility of the device cannot be met.

Disclosure of Invention

The invention provides a material closed circulation processing line which is used for solving the defect that the flexibility of closed equipment in the related technology is poor and the requirements of drug production on the maneuverability and mobility of the equipment cannot be met; when the mobile equipment is needed, the equipment can be conveniently detached, and meanwhile, the tightness of the equipment is kept, so that the operability and the mobility of the equipment are improved.

The invention provides a material closed circulation treatment line, which comprises:

the feeding device comprises a feeding barrel, wherein a first valve body is arranged at an opening of the feeding barrel and used for controlling the opening to be opened or closed;

the material processing device, material processing device's first import department is equipped with the second valve body, material processing device's first exit is equipped with the third valve body, the second valve body with the third valve body is used for sealing or opening material processing device, just the second valve body with the third valve body is used for with first valve body can dismantle the connection.

According to the material closed circulation treatment line provided by the invention, the material treatment device comprises a wet granulator, and the second valve body is arranged on the wet granulator; and the second valve body is used for controlling the first inlet of the wet granulator to be opened or closed.

According to the material airtight circulation treatment line provided by the invention, the wet granulator is provided with the discharging plug and the plug driving piece, the discharging plug is movably arranged in the second outlet of the wet granulator in a penetrating way, the plug driving piece is connected with the discharging plug, and the plug driving piece is used for driving the discharging plug to seal or open the second outlet.

According to the material airtight circulation treatment line provided by the invention, the wet granulator is also internally provided with the material propeller, and the material propeller is used for pushing the granulated material to the second outlet.

According to the material closed circulation treatment line provided by the invention, the material treatment device further comprises a wet granulator, and the wet granulator is communicated with the second outlet in a sealing way.

According to the material closed circulation treatment line provided by the invention, the material treatment device further comprises a fluidized bed, the fluidized bed is communicated with the wet granulator, and the fluidized bed is used for drying the particles of the wet granulator.

According to the material airtight circulation treatment line provided by the invention, the wet granulator and the fluidized bed are communicated through the connecting pipeline, the connecting pipeline is provided with the control valve, and the control valve is used for controlling the wet granulator and the fluidized bed to be communicated or disconnected.

According to the material closed circulation treatment line provided by the invention, the material treatment device further comprises a dry granulator, and the dry granulator is communicated with the fluidized bed; the first outlet of the dry granulator is provided with the third valve body.

According to the material airtight circulation processing line provided by the invention, the first valve body is one of the AB valves, and the second valve body and the third valve body are the other one of the AB valves.

According to the material closed circulation treatment line provided by the invention, the material closed circulation treatment line further comprises a mixing device, wherein the mixing device is used for being connected with the charging barrel and driving the charging barrel.

According to the material airtight circulation treatment line, the first valve body is arranged at the opening of the charging barrel, the second valve body is arranged at the first inlet of the material treatment device, and the third valve body is arranged at the first outlet of the material treatment device; the second valve body and the third valve body are detachably connected with the first valve body; thus, when the materials are required to be subjected to airtight treatment, the first valve body and the second valve body of the charging barrel can be connected; at the moment, the first valve body and the second valve body can be simultaneously opened, so that the airtight circulation of materials among devices is ensured, and operators are protected; or connecting the first valve body and the third valve body of the charging barrel to form closed circulation of materials; when the materials are required to be transferred, the first valve body, the second valve body and the third valve body can be respectively closed; in this way, in the material processing device, the second valve body and the third valve body are closed, so that a closed or airtight space is formed, and the pollution of the external environment to the interior of the material processing device can be avoided; in addition, for the materials in the charging barrel, as the first valve body is closed, the materials are sealed in the charging barrel and isolated from the external environment, and the pollution of the external environment to the materials can be avoided; in addition, the flexibility of transferring and circulating the materials is improved, the material cylinder can be conveniently detached from the material treatment equipment and the materials are transferred to the next procedure for treatment, and the operability and the mobility of the equipment are improved.

Drawings

In order to more clearly illustrate the invention or the technical solutions of the prior art, the following description will briefly explain the drawings used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are some embodiments of the invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of the overall structure of a material closed circulation processing line according to an embodiment of the present invention;

FIG. 2 is a schematic diagram of a cartridge in a material containment flow processing line according to an embodiment of the present disclosure;

FIG. 3 is a schematic diagram of a structure of a material cylinder and a material processing device in a material closed circulation processing line according to an embodiment of the present invention;

fig. 4 is a schematic structural diagram of the cooperation of a wet granulator and a wet granulator in a material closed circulation treatment line according to an embodiment of the present invention;

FIG. 5 is a schematic diagram of a wet granulator in a material closed flow treatment line and a fluidized bed in cooperation with each other according to an embodiment of the present invention;

FIG. 6 is a schematic diagram of the cooperation of a fluidized bed and a dry granulator in a material closed circulation treatment line according to an embodiment of the present invention;

fig. 7 is a schematic structural diagram of a mixing device and a charging barrel in a material closed circulation processing line according to an embodiment of the present invention.

Reference numerals:

10-a charging barrel; 20-a material handling device; 30-a mixing device;

110-a first valve body; 201-a first inlet; 202-a first outlet; 210-a second valve body; 220-a third valve body; 230-a wet granulator; 231-discharging plugs; 232-plug drive; 233-a second outlet; 234—a material pusher; 240-wet granulator; 250-fluidized bed; 260-connecting a pipeline; 261-control valve; 270-a dry granulator; 280-a frame.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

In the description of the embodiments of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the embodiments of the present invention and simplifying the description, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the embodiments of the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In describing embodiments of the present invention, it should be noted that, unless explicitly stated and limited otherwise, the terms "coupled," "coupled," and "connected" should be construed broadly, and may be either a fixed connection, a removable connection, or an integral connection, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium. The specific meaning of the above terms in embodiments of the present invention will be understood in detail by those of ordinary skill in the art.

In embodiments of the invention, unless expressly specified and limited otherwise, a first feature "up" or "down" on a second feature may be that the first and second features are in direct contact, or that the first and second features are in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the embodiments of the present invention. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.

In the pharmaceutical or chemical industry, the throughput of solid preparations is enormous, and the most one is in contact with daily life, such as solid tablets, granules, capsules, etc. which are usually taken. It is understood that some drugs have certain side effects or toxicity to normal organisms, and in the production process, operators may cause great harm to human bodies if the protection is improper.

In addition, for some medicines containing active ingredients, the medicines can be polluted and destroyed by exposure to the environment, and the medicines can be polluted by pollutants existing in the environment, so that the curative effect of the medicines is destroyed.

In the related art, the product is completely isolated from operators and the external environment by the airtight circulation of materials, so that the operators and the environment are protected, and in addition, the medicine can be protected from pollution.

However, in the related art, after the drug production device meets the corresponding sealing condition, the device flexibility is poor, and the requirements of drug production on the operability and the mobility of the device cannot be met.

Fig. 1 is a schematic overall structure of a material sealed circulation processing line provided by an embodiment of the present invention, and fig. 2 is a schematic structural diagram of a material cylinder in the material sealed circulation processing line provided by the embodiment of the present invention.

Referring to fig. 1 and 2, an embodiment of the present invention provides a material closed circulation processing line, including: a cartridge 10 and a material handling device 20.

Specifically, in the embodiment of the invention, the material closed circulation processing line can be a production process circulation/flow line, or a process circulation/flow line of the processes of material granulation, pretreatment, intermediate treatment and the like.

It will be appreciated that cartridge 10 is typically used to hold materials such as various pre-samples, intermediates or finished products in pharmaceutical applications. Accordingly, the cartridge 10 typically has a cavity (which may also be referred to as a receiving space or cavity in some examples) therein for receiving material, and one end of the cartridge 10 has an opening that communicates with the cavity and the external environment for adding material to the cartridge 10 or removing material from the cartridge 10.

In the embodiment of the present invention, the material cylinder 10 may be made of stainless steel, aluminum alloy, or the like. In some examples, cartridge 10 may also be made of plastic, such as food grade plastic or medical grade plastic.

Referring to fig. 1 and 2, in the embodiment of the present invention, a first valve body 110 is disposed at an opening of a cartridge 10, and the first valve body 110 is used for closing the opening.

It is understood that in the embodiment of the present invention, the first valve body 110 may be any one of a manual valve or an electric valve.

When specifically provided, the first valve body 110 may be connected to the rim of the cartridge 10 by a flange. That is, a flange may be disposed at the edge of the cartridge 10, and a flange may be disposed on the first valve body 110, and the two flanges are fastened and sealed by a connection member such as a bolt, a screw, or a screw, so as to ensure the tightness of the connection between the first valve body 110 and the cartridge 10.

In an alternative example of embodiment of the present invention, a gasket may be provided between the flange on the first valve body 110 and the flange on the rim of the cartridge 10. When the sealing gasket is specifically arranged, the sealing gasket can be selectively arranged according to the actual sealing grade. By way of illustration, in one specific example, the seal rating of the gasket may be set according to the seal rating of OEB4 in embodiments of the present invention.

It will be appreciated that in embodiments of the present invention, the sealing of the first valve body 110 to the cartridge 10 may also be provided according to the corresponding sealing rating requirements, such as the OEB4 sealing rating mentioned in the previous embodiments of the present invention.

Referring to fig. 1, in the embodiment of the present invention, a second valve body 210 is disposed at a first inlet 201 of a material handling device 20, a third valve body 220 is disposed at a first outlet 202 of the material handling device 20, the second valve body 210 and the third valve body 220 are used for sealing the material handling device 20, and the second valve body 210 and the third valve body 220 are used for being detachably connected with the first valve body 110.

Specifically, in the embodiment of the present invention, the first inlet 201 may be specifically an inlet of the material handling device 20, that is, after the material exits from the opening of the barrel 10, the material enters the material handling device 20 from the first inlet 201 to be handled, and specifically, in the material handling device 20, the material may be subjected to granulation. Of course, it will be appreciated that in some possible examples, the material handling apparatus 20 may also be configured to perform some other process on the material, such as a drying process, a tabletting process, etc. The material handling device 20 may perform some conventional processes in pharmaceutical processes on materials, and may refer to a process for handling materials in related art, which is not described in detail in this embodiment of the present invention.

In a specific arrangement, the opening edge of the first inlet 201 may be provided with a flange, and the second valve body 210 may be connected and fixed with the material handling device 20 through the flange. In the embodiment of the present invention, the first valve body 110 and the second valve body 210 may be in airtight fit. For example, an extension portion may be provided at a side of the first valve body 110 facing the second valve body 210, and the extension portion may be inserted into the second valve body 210 and hermetically coupled with the second valve body 210. In other possible examples, an extension may be provided on the second valve body 210, and the extension of the second valve body 210 may be inserted into the first valve body 110, thereby forming a sealed fit between the second valve body 210 and the first valve body 110. It will be appreciated that in some examples, a locking structure may also be provided on either the first valve body 110 or the second valve body 210, and after the first valve body 110 is mated with the second valve body 210, the locking structure may be locked, thereby ensuring a tight mating of the first valve body 110 with the second valve body 210. The locking structure may specifically be a clip disposed on one of the first valve body 110 and the second valve body 210, where one end of the clip is clamped and fixed with the other of the first valve body 110 and the second valve body 210, so as to ensure tightness after the first valve body 110 and the second valve body 210 are mutually connected and matched.

When the material transferring device is specifically used, materials can be placed into the material barrel 10, for example, the first valve body 110 of the material barrel 10 is in butt joint with the outlet of the material adding device, the materials are added into the material barrel 10, and then the first valve body 110 is closed, so that the materials in the material barrel 10 are sealed, transferred or transferred, harm to operators or environment in the material transferring process can be avoided, and the condition that the environment pollutes the materials can be avoided.

In addition, after transferring the material to the material handling apparatus 20, the first valve body 110 and the second valve body 210 may be cooperatively connected, and after sealing is ensured; the first valve body 110 and the second valve body 210 are opened to deliver material into the material handling device 20 for processing.

In addition, after the material processing device 20 processes the processed material, the first valve body 110 and the third valve body 220 of the material barrel 10 can be connected in a matched manner, so that after sealing is ensured, the first valve body 110 and the third valve body 220 are opened, and the processed material is transferred into the material barrel 10, so that the transfer circulation of the material barrel 10 to the material is facilitated. It should be understood that, in the embodiment of the present invention, the specific arrangement manner of the third valve body 220 may be the same as or similar to that of the second valve body 210, and in addition, the mating connection manner of the third valve body 220 and the first valve body 110 may also be the same as or similar to that of the second valve body 210, and specific reference may be made to the detailed description of the second valve body 210 in the foregoing embodiment of the present invention, which is not repeated in the embodiment of the present invention.

In the material airtight circulation processing line provided by the embodiment of the invention, the first valve body 110 is arranged at the opening of the charging barrel 10, the second valve body 210 is arranged at the first inlet 201 of the material processing device 20, and the third valve body 220 is arranged at the first outlet 202 of the material processing device 20; the second valve body 210 and the third valve body 220 are detachably connected with the first valve body 110; thus, when the material needs to be subjected to sealing treatment, the first valve body 110 and the second valve body 210 of the charging barrel 10 can be connected; at this time, the first valve body 110 and the second valve body 210 can be opened at the same time, so that the airtight circulation of the materials between the devices is ensured, and the operators are protected; alternatively, the first valve body 110 of the cartridge 10 is connected to the third valve body 220 to form a closed circulation of the material; when the material is required to be transferred, the first valve body 110, the second valve body 210 and the third valve body 220 can be respectively closed; in this way, in the material handling apparatus 20, since the second valve body 210 and the third valve body 220 are closed, a closed or airtight space is formed, and pollution to the interior of the material handling apparatus 20 caused by the external environment can be avoided; in addition, for the material in the material cylinder 10, as the first valve body 110 is closed, the material is sealed in the material cylinder 10 and isolated from the external environment, and the pollution of the external environment to the material can be avoided; in addition, flexibility in material transfer circulation is improved, and the material cartridge 10 can be conveniently detached from the material handling apparatus and transferred to the next process for handling, thereby improving the operability and portability of the apparatus.

Fig. 3 is a schematic structural diagram of a material cylinder and a material processing device in a material closed circulation processing line according to an embodiment of the present invention.

Referring to fig. 1 and 3, in an alternative example of the embodiment of the present invention, the material handling apparatus 20 includes a wet granulator 230, and the second valve body 210 is disposed on the wet granulator 230; and the second valve body 210 is used to seal the first inlet 201 of the wet granulator 230.

Specifically, referring to fig. 1, in the embodiment of the present invention, the wet granulator 230 includes a machine body, and a wet granulation pot is arranged in the machine body, and when the first valve body 110 and the second valve body 210 of the charging barrel 10 are in butt joint during specific granulation, the second valve body 210 and the first valve body 110 are opened in sequence, and the material enters into the wet granulation pot for granulation. When specifically setting up, still be equipped with parts such as reducing gear box, pivot, first driving motor on the fuselage, first driving motor passes through the reducing gear box and is connected with the pivot, and the pivot extends to in the fuselage to be connected with wet granulation pot, so, first driving motor carries out the pelletization through driving wet granulation pot.

As a specific example of an embodiment of the present invention, the wet granulator 230 may be specifically a pan-changeable wet granulator 230. Thus, the granulating pan of the wet granulator 230 can be conveniently replaced, and a proper granulating pan can be conveniently selected according to different materials or different granulating particle sizes, so that the utilization rate of equipment is improved.

With continued reference to fig. 3, in embodiments of the present invention, when specifically configured, a feed hopper (also referred to as a feed hopper in some examples) may be disposed on the body of the wet granulator 230, where the bottom end of the feed hopper is in communication with the interior of the body of the wet granulator 230 (e.g., may be connected by a flange), and the top end of the feed hopper is connected to the second valve body 210 by a flange. That is, in the embodiment of the present invention, during the feeding process of the material handling apparatus 20, the material cylinder 10 may be located at/above the top of the material handling apparatus 20, so that the material flow may be transferred into the material handling apparatus 20 by using gravity, and the energy required for the material flow may be saved. Referring to fig. 3, the material may flow from the cartridge 10 into the wet granulator 230 in the direction indicated by the arrow in fig. 3 for granulation.

As an alternative example of the embodiment of the present invention, the first valve body 110 may be an a valve of the AB valve, and the second valve body 210 may be a B valve of the AB valve.

Specifically, in some alternative examples of embodiments of the invention, the AB valve may also be referred to as an αβ valve, typically comprising one active valve and one passive valve. In the embodiment of the present invention, the first valve body 110 may be an active valve, and the second valve body 210 is a passive valve; of course, in some examples, the first valve body 110 may also be a passive valve and the second valve body 210 an active valve. That is, in some examples, the first valve body 110 may also be a B valve of an AB valve and the second valve body 210 may be an a valve of the AB valve.

Embodiments of the present invention utilize one of the AB valves as the first valve body 110 and the other of the AB valves as the second valve body 210; in this way, the connection fitting and the disassembly of the first valve body 110 and the second valve body 210 are facilitated; after the first valve body 110 and the second valve body 210 are coupled together, a desired level of sealing, such as OEB4 sealing in the previous embodiments of the present invention, can be achieved. In addition, the sealing performance in the process of drug or material transfer can be ensured, and the damage to operators or the environment can be avoided; the valve body can be conveniently disinfected and sterilized, and the sterile environment for material circulation is ensured.

It is understood that in the embodiment of the present invention, the third valve body 220 may also be a B valve or an a valve of the AB valve; for example, in the case where the first valve body 110 is the a valve of the AB valve, the third valve body 220 is the B valve of the AB valve, and in the case where the first valve body 110 is the B valve of the AB valve, the third valve body 220 is the a valve of the AB valve.

Fig. 4 is a schematic structural diagram of the cooperation of a wet granulator and a wet granulator in a material closed circulation treatment line according to an embodiment of the present invention.

In an alternative example of the embodiment of the present invention, the wet granulator 230 is provided with a discharge plug 231 and a plug driving member 232, the discharge plug 231 is movably disposed in the second outlet 233 of the wet granulator 230, the plug driving member 232 is connected with the discharge plug 231, and the plug driving member 232 is used for driving the discharge plug 231 to close or open the second outlet 233.

Specifically, in the embodiment of the present invention, the discharging plug 231 may be a silica gel pad made of medical silica gel, and the discharging plug 231 may be sealed and disposed in the second outlet 233; that is, the peripheral wall of the discharge plug 231 is hermetically connected to the inner wall of the second outlet 233. It will be appreciated that, in general, the silica gel has a certain deformation amount, and thus, after the discharging plug 231 is in sealing/airtight connection with the second outlet 233, the discharging plug may also move along the axial direction of the second outlet 233, i.e. have a certain degree of freedom in the axial direction of the second outlet 233.

In the embodiment of the present invention, the plug driving element 232 may specifically be a driving mechanism such as a piston cylinder, an air cylinder, an electric cylinder or a linear motor; the output shaft of the plug driver 232 may be disposed through the second outlet 233 and connected to the discharge plug 231. In a specific setting, the discharging plug 231 may be fixedly connected with the output shaft of the plug driving member 232, so that when the output shaft of the plug driving member 232 moves along the axial direction of the second outlet 233, the discharging plug 231 is driven to move, and the second outlet 233 is closed or opened.

Specifically, in the embodiment of the present invention, when the wet granulator 230 performs granulation, referring to fig. 4, the plug driving member 232 may drive the discharge plug 231 to move along the direction shown by the x-axis in fig. 4, so as to seal the second outlet 233; after the wet granulator 230 completes granulation, the plug driver 232 drives the discharge plug 231 to move in the y direction in fig. 4, thereby opening the second outlet 233.

It can be appreciated that, in a specific arrangement, in the embodiment of the present invention, an observation window may be provided on the body of the wet granulator 230, and the observation window may be specifically made of transparent materials such as tempered glass, high borosilicate, etc., so as to facilitate an operator to observe the granulation progress in the wet granulator 230.

In some possible examples, wet granulator 230 may also determine the time to granulate based on the different materials, as well as the amount of material (e.g., volume of material, mass, particle size of granulate, etc.), and determine whether the wet granulation process is complete by the time to granulate.

In the embodiment of the invention, the second outlet 233 of the wet granulator 230 is plugged and opened through the discharging plug 231 and the plug driving piece 232, so that the second outlet 233 is conveniently plugged during granulation, and after granulation, the second outlet 233 is opened, thereby improving the convenience of plugging and opening the second outlet 233; in addition, the tightness of the material treatment equipment in the whole material treatment circulation process is ensured.

With continued reference to fig. 3 and 4, in an alternative example of an embodiment of the present invention, a material pusher 234 is further provided in the wet granulator 230, and the material pusher 234 is configured to drive the wet granulator 230 to the second outlet 233 to complete the granulation of the material.

It will be appreciated that in embodiments of the present invention, after granulation is completed in wet granulator 230, the granulated material may be transferred to a subsequent processing mechanism for processing. This requires the movement of the material. In the embodiment of the present invention, the material pusher 234 is disposed in the wet granulator 230, so that the material can be conveniently moved to the second outlet 233 and transferred from the second outlet 233 to the subsequent processing mechanism for processing.

Specifically, in the embodiment of the present invention, the material pusher 234 may be a screw pusher or a pushing mechanism such as a cylinder, a piston cylinder, an electric cylinder, and a linear motor; referring to fig. 4, the material mover 234 may specifically move or move material in the y-direction of fig. 4 to the second outlet 233. That is, in the embodiment of the present invention, the moving or driving direction of the material pusher 234 to the material may be the same as, the same as or similar to the moving direction of the discharging plug 231 to open the second outlet 233; that is, in the embodiment of the present invention, the material pusher 234 may drive or move the material while the plug driving member 232 drives the discharging plug 231 to open the second outlet 233, so that the material is timely discharged from the second outlet 233, thereby ensuring the continuity of material processing.

With continued reference to fig. 4, in an alternative example of an embodiment of the invention, the material handling apparatus 20 further includes a wet granulator 240, the wet granulator 240 being in sealed communication with the second outlet 233.

Specifically, referring to fig. 4, in the embodiment of the present invention, a connection pipe 260 may be connected between the wet granulator 240 and the wet granulator 230, where the connection pipe 260 may specifically be connected to the second outlet 233 in the vertical direction, so that the material may enter the wet granulator 240 under the action of gravity, and the energy required to be consumed in the material circulation process may be reduced.

When specifically configured, the connecting pipe 260 may be connected to the wet granulator 240 by a flange; the connection pipe 260 may be a pipe made of stainless steel, among others.

As a specific example of an embodiment of the present invention, the connection pipe 260 may also be a hose made of polyurethane (Thermoplastic Urethane, abbreviated as TPU) material, wherein the diameter of the hose may be 3.5-4.5 inches. It will be appreciated that in embodiments of the invention, the hose may be of other dimensions, and in particular may be determined based on the throughput of material per unit time. In addition, other types of materials may be selected for the hose, and the material of the hose in the embodiment of the present invention is only shown as a specific example, and the specific material of the hose is not limited thereto. In a specific example of an embodiment of the invention, the hose may have a diameter of 3.5 inches.

According to the embodiment of the invention, the hose is used for connecting the wet granulator 230 and the wet granulator 240, so that the problem that the wet granulator 230 and the wet granulator 240 are difficult to mount and align due to mounting errors can be avoided, the requirement on the mounting precision between the wet granulator 230 and the wet granulator 240 can be reduced, and the mounting efficiency of the wet granulator 230 and the wet granulator 240 during mounting is improved.

Fig. 5 is a schematic structural diagram of the cooperation of the wet granulator and the fluidized bed in the material airtight circulation treatment line provided by the embodiment of the invention.

Referring to fig. 5, in another alternative example of an embodiment of the present invention, the material handling apparatus 20 further includes a fluidized bed 250, the fluidized bed 250 being in communication with the wet granulator 240, the fluidized bed 250 being configured to dry particulate matter from the wet granulator 240.

Specifically, in the embodiment of the present invention, the wet granulator 240 and the fluidized bed 250 may be connected by a TPU hose, where the TPU hose may be disposed obliquely with respect to the axis of the wet granulator 240, so, referring to fig. 5, the fluidized bed 250 may be disposed on one side of the wet granulator 240, so as to ensure that the fluidized bed 250 has a sufficient space in the vertical direction, and ensure that the wet granulator 240 is sufficiently fluidized and dried to obtain the granules after finishing wet granulation.

In a specific arrangement, in an embodiment of the present invention, the angle of inclination between the axis of soft turning of the TPU and the axis of the wet granulator 240 may be 30 ° -45 °, which facilitates the entry of material from the wet granulator 240 into the bin of the fluidized bed 250 under the force of gravity.

As a specific example of an embodiment of the invention, referring to fig. 5, a TPU hose may be connected specifically at a middle position of the fluidized bed 250, and an air inlet/air inlet of the fluidized bed 250 may be provided at the bottom; in this way, the material entering the bin of the fluidized bed 250 from the middle can be fluidized and dried by air intake or air intake from the bottom. Referring to fig. 5, in some alternative examples of embodiments of the invention, the gas vent of the fluidized bed 250 may be provided at the top of the fluidized bed 250. It will be appreciated that in the embodiment of the present invention, the exhaust port of the fluidized bed 250 may be connected to a purifying apparatus (not shown in the drawings) through a pipeline, and the purifying apparatus may be provided with a filtering member, a cyclone dust removing mechanism or other dust removing mechanisms, so as to remove dust from materials carried in the gas exhausted from the fluidized bed 250, and exhaust clean gas, thereby avoiding pollution to the external environment.

In an alternative example of an embodiment of the present invention, the diameter of the TPU hose connected between the wet granulator 240 and the fluidized bed 250 may be 3 inches to 5 inches, and as a specific example, the diameter of the TPU hose may be 3 inches.

It should be noted that, the numerical values and the numerical ranges related to the embodiments of the present invention are approximate values, and may have a certain range of errors under the influence of the manufacturing process, and those errors may be considered to be negligible by those skilled in the art.

It will be appreciated that in embodiments of the present invention, a control valve 261 may be provided on the TPU hose, and that the control valve 261 may close off or connect the TPU hose between the wet granulator 240 and the fluidized bed 250.

In some alternative examples of embodiments of the invention, the control valve 261 may be in particular an electric valve or a pneumatic valve; the wet granulator 240 may be provided with an observation window, through which an operator can determine whether wet granulation is completed; of course, in some examples, it may be determined whether wet finishing is completed by the wet finishing time, and after the wet finishing is completed, the control valve 261 may be opened.

As a specific example of an embodiment of the present invention, the control valve 261 may also be a manual valve, such as a manual butterfly valve. After the operator confirms that wet granulation is complete, the manual valve may be opened so that the material in the wet granulator 240 enters the bin of the fluidized bed 250 under the force of gravity.

It will be appreciated that in some examples of embodiments of the present invention, the overall radial dimension of the fluidized bed 250 may be greater than the radial dimension of the wet granulator 240, so that when the material is dried in the bin of the fluidized bed 250, the material has enough space to fluidize, so that the contact area between the material and the drying gas can be increased, and the drying efficiency is improved.

It will also be appreciated that in embodiments of the present invention, a viewing window is also provided on the fluidized bed 250 to facilitate an operator in determining whether the fluidized drying process is complete.

Fig. 6 is a schematic structural diagram of the cooperation of a fluidized bed and a dry granulator in a material closed circulation treatment line according to an embodiment of the present invention.

Referring to fig. 6, in some alternative examples of embodiments of the invention, the material handling apparatus 20 further includes a dry granulator 270, the dry granulator 270 being in communication with the fluidized bed 250; the first outlet 202 of the dry pelletizer 270 is provided with a third valve body 220.

Specifically, in embodiments of the present invention, the dry granulator 270 may be disposed at the bottom outlet of the fluidized bed 250, i.e., the dry granulator 270 is in communication with the bottom outlet of the fluidized bed 250. The dry granulator 270 and the fluidized bed 250 may also be in communication via TPU hoses when specifically configured. Here, the TPU hose may have a diameter of 4 inch TPU hose. It will be appreciated that the TPU hose may be of other sizes, and this is not a limitation in embodiments of the present invention.

Referring to fig. 6, in the embodiment of the present invention, the bottom of the fluidized bed 250 may be configured to have a necking structure, or in some examples, the bottom of the fluidized bed 250 may be configured to have a funnel-shaped structure, so that the dried material of the fluidized bed 250 can be collected in a concentrated manner conveniently.

It should be understood that, in the embodiment of the present invention, the control valve 261 may also be disposed on the TPU hose between the fluidized bed 250 and the dry granulator 270, where the control valve 261 may be the same as or similar to the control valve 261 in the previous example of the embodiment of the present invention, and specific reference may be made to the detailed description in the previous embodiment, which is not repeated in the embodiment of the present invention.

It will be appreciated that in embodiments of the present invention, the third valve body 220 is disposed at the first outlet 202 of the dry pelletizer 270; in a specific arrangement, the third valve body 220 may also be connected to the rim of the first outlet 202 by a flange. For a specific description of the third valve body 220, reference may be made to the detailed description of the foregoing embodiments of the present invention, which will not be repeated herein.

In this way, during the process of circulating the material in the material processing device 20, the third valve body 220 may be in a closed state, or during the process of dry granulation in the dry granulator 270, the third valve body 220 may be in a closed state, so as to ensure that the whole circulating process of the material in the material processing device 20 is in a sealed or sealed state, and reduce damage to operators and the environment; in addition, the material can be prevented from being polluted by the environment, and the drug effect of the drug is ensured.

After the material treatment is completed, the first valve body 110 and the third valve body 220 on the material barrel 10 can be connected in a matched manner, and the third valve body 220 and the first valve body 110 are opened in sequence, so that the dried and granulated material is transferred into the material barrel 10, and the material barrel 10 is conveniently removed to transfer or move after the material barrel 10 is sealed through the first valve body 110, so that the material can be treated in other working procedures.

Fig. 7 is a schematic structural diagram of a mixing device and a charging barrel in a material closed circulation processing line according to an embodiment of the present invention.

For example, referring to fig. 7, in another alternative example of the embodiment of the present invention, the material circulation processing line further includes a mixing device 30, where the mixing device 30 is used to connect with the cartridge 10 and drive the cartridge 10.

Specifically, referring to fig. 7, in the embodiment of the present invention, the barrel 10 may be detached from the material handling device 20, then connected to the rotating shaft of the mixing device 30, and then the driving motor on the mixing device 30 drives the rotating shaft, so that the barrel 10 vibrates or rotates, thereby mixing the materials in the barrel 10. In some possible examples, a manipulator may be provided on the axis of rotation of the mixing device 30, by which the cartridge 10 is held.

After mixing, the cartridge 10 may be transferred to a subsequent processing step, such as tabletting or capsule filling.

In an alternative example of an embodiment of the present invention, the material is hermetically circulated to process the wire steps, steps or ladders and the rack 280; the material handling apparatus 20 is disposed on a frame 280, and a step, step or cat ladder is connected to the frame 280. In this way, the operator is facilitated to transport and connect the cartridge 10 to the material handling device 20.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. A material closed circulation processing line, comprising:

a first valve body (110) is arranged at the opening of the charging barrel (10), and the first valve body (110) is used for controlling the opening to be opened or closed;

the material handling device (20), first import (201) department of material handling device (20) is equipped with second valve body (210), first export (202) department of material handling device (20) is equipped with third valve body (220), second valve body (210) with third valve body (220) are used for sealed or open material handling device (20), just second valve body (210) with third valve body (220) are used for with first valve body (110) detachable connection.

2. The material closed circulation processing line according to claim 1, wherein the material processing device (20) comprises a wet granulator (230), and the second valve body (210) is disposed on the wet granulator (230); and the second valve body (210) is used for controlling the first inlet (201) of the wet granulator (230) to be opened or closed.

3. The material airtight circulation treatment line according to claim 2, wherein a discharge plug (231) and a plug driving member (232) are disposed on the wet granulator (230), the discharge plug (231) movably penetrates through a second outlet (233) of the wet granulator (230), the plug driving member (232) is connected with the discharge plug (231), and the plug driving member (232) is used for driving the discharge plug (231) to close or open the second outlet (233).

4. A material circulation treatment line according to claim 3, characterized in that a material pusher (234) is further arranged in the wet granulator (230), and the material pusher (234) is used for pushing the granulated material to the second outlet (233).

5. A material closed flow processing line according to claim 3, characterized in that the material handling device (20) further comprises a wet granulator (240), the wet granulator (240) being in sealed communication with the second outlet (233).

6. The material containment flow processing line of claim 5, wherein the material handling apparatus (20) further comprises a fluidized bed (250), the fluidized bed (250) being in communication with the wet granulator (240), the fluidized bed (250) being configured to dry the granulated material from the wet granulator (240).

7. The material closed circulation treatment line according to claim 6, wherein the wet granulator (240) and the fluidized bed (250) are communicated through a connecting pipeline (260), a control valve (261) is arranged on the connecting pipeline (260), and the control valve (261) is used for controlling the wet granulator (240) and the fluidized bed (250) to be communicated or disconnected.

8. The material containment flow processing line of claim 6, wherein the material handling apparatus (20) further comprises a dry granulator (270), the dry granulator (270) in communication with the fluidized bed (250); the first outlet (202) of the dry granulator (270) is provided with the third valve body (220).

9. The material closed flow processing line according to any one of claims 1 to 8, wherein the first valve body (110) is one of AB valves, and the second valve body (210) and the third valve body (220) are the other one of AB valves.

10. The material closed circulation processing line according to any one of claims 1-8, further comprising a mixing device (30), wherein the mixing device (30) is configured to be connected to the cartridge (10) and to drive the cartridge (10).