CN116725917A - Acne-removing composition and preparation method and application thereof - Google Patents

Abstract

The invention discloses an anti-acne composition and its preparation method and application. The anti-acne composition of the present invention contains antibacterial ingredients, oil-controlling and acne mark-fading ingredients, anti-inflammatory and soothing ingredients, repairing ingredients, supramolecular solvents, and Neosolue ^TM -Aqulio; targeting the stages and mechanisms of acne formation, multi-dimensional targets inhibit acne . First, anti-inflammatory and soothing ingredients are combined with repairing ingredients and antibacterial ingredients are delivered deep into the acne muscles by supramolecular solvents and Neosolue ^TM -Aqulio to unclog pores, relieve acne swelling and pain, regulate oil secretion, remove redness and repair, and fade acne marks, etc. Efficacy; Finally, it is compounded with Pionin, which has a bactericidal effect, to accelerate the re-establishment of microecological balance; ultimately, it can achieve short-term anti-inflammatory, redness and soothing to long-term oil control, repair, acne mark removal, and microecological balance, thereby improving acne-related skin problems. question.

Description

An anti-acne composition and its preparation method and application

Technical field

The invention relates to the field of cosmetics, and in particular to an anti-acne composition and its preparation method and application.

Background technique

Acne, also known as acne and pimples, mostly occurs in adolescence, but after puberty, the androgens in the body slowly fade away, and acne can often be relieved or cured naturally. However, with the rapid development of society, people's life and work pressure are increasing, eating too exciting food, staying up late and other reasons, more and more adults have facial acne, which has a certain impact on people's psychology and social life.

At present, the pathogenesis of acne has not been fully studied. It is generally believed that the rise of male hormones (mainly testosterone) in the body converts 5a-reductase in hair follicles and sebaceous glands into more active dihydrotestosterone, which promotes biochemical reactions and makes oil The secretion is increased, and at the same time, the sebaceous ducts and hair follicle cells are excessively keratinized, thereby sealing the sebaceous ducts or hair follicle ducts, forming acne and forming an anaerobic microenvironment that is conducive to the colonization of Propionibacterium acnes. In an anaerobic environment, Propionibacterium acnes proliferates in large numbers, produces lipolytic enzymes, decomposes sebum and produces free acid, which stimulates hair follicles and causes inflammation, causing damage to the hair follicle wall and rupture, and accumulated sebum entering the dermis, causing insufficiency around the hair follicles. inflammatory response. Therefore, people's demand for skin care products with anti-acne properties is increasing.

Currently, the solutions for acne on the market mainly use retinoic acid, antibiotics, hormones, salicylic acid, azelaic acid, fruit acids, pure plant extracts, laser acne removal and other solutions to treat acne, but they all exist. Certain limitations. Although retinoic acid, antibiotics, and hormones are effective in treating acne, long-term use can cause dependence. Once you stop using it, acne may reoccur; acid products are highly irritating to the skin, and if used for a long time, it will cause Increases skin sensitivity; pure plant extract products are targeted to a certain extent, although relatively mild, but the results are slow; laser acne removal uses physical methods to quickly remove acne, but cannot fundamentally cure acne. Most of these anti-acne products mainly use sterilization and anti-inflammatory as their main functions to treat early-stage acne, but pay less attention to the later-stage skin repair and elimination of acne marks.

Therefore, the existing technology still needs to be improved and developed.

Contents of the invention

In order to improve the all-round efficacy of anti-acne products, the purpose of the present invention is to provide an anti-acne composition and its preparation method and application, so as to solve the problem that existing anti-acne compositions cannot comprehensively and efficiently remove acne, and achieve a short-term Anti-inflammatory, redness and soothing to long-term oil control, repair, acne mark removal, microecological balance, thereby improving acne-related problems.

The technical solution of the present invention is as follows:

A first aspect of the present invention provides an anti-acne composition, wherein, by weight, the anti-acne composition includes: 0.05-0.1 parts of Pionin, 5-12 parts of Potassium Azelayldiglycinate, 1 part -3 parts Sophora flavescens root extract, 0.01-2 parts Gentian extract, 1-3 parts White Willow Bark extract, 1-3 parts Kava pepper extract, 1-3 parts Licorice extract, 1-17 parts Purslane extract, 1-5 parts glycerol glucoside, 1-45 parts polyol, 1-20 parts supramolecular solvent, 1-20 parts Neosolue ^TM -Aqulio.

Optionally, the polyol is at least one of butanediol and pentanediol.

Optionally, the supramolecular solvent is betaine citric acid.

Optionally, in parts by weight, the anti-acne composition consists of the following components: 0.05-0.1 parts of Pionin, 5-12 parts of potassium azelayldiglycinate, 1-3 parts of Sophora flavescens root extract, 0.01-2 parts gentian extract, 1-3 parts white willow bark extract, 1-3 parts kava pepper extract, 1-3 parts licorice extract, 1-17 parts purslane extract, 1-5 parts glyceryl glucoside, 1-45 parts polyol, 1-20 parts betaine citric acid, 1-20 parts Neosolue ^TM -Aqulio.

The second aspect of the present invention provides a method for preparing the anti-acne composition of the present invention, which includes the steps of: mixing 0.05-0.1 parts of Pionin, 5-12 parts of Potassium Azelayldiglycinate, 1-3 parts Sophora flavescens root extract, 0.01-2 parts gentian extract, 1-3 parts white willow bark extract, 1-3 parts kava pepper extract, 1-3 parts licorice extract, 1-17 parts purslane The extract, 1-5 parts of glycerol glucoside, 1-45 parts of polyol, 1-20 parts of supramolecular solvent, and 1-20 parts of Neosolue ^TM -Aqulio are mixed and stirred to obtain the anti-acne composition.

Optionally, in parts by weight, the preparation method of the anti-acne composition specifically includes the steps:

Mix 0.05-0.1 parts of Pionin, 1-3 parts of Kava pepper extract, 1-20 parts of betaine citric acid, and 1-25 parts of butylene glycol, and heat and dissolve to obtain solution 1;

Add 1-5 parts of glycerol glucoside, 5-15 parts of pentylene glycol, and 1-20 parts of Neosolue ^TM -Aqulio to solution 1 in sequence, and stir ultrasonically to obtain solution 2;

Mix 20-50 parts of deionized water, 0.01-2 parts of gentian extract, and 1-5 parts of butanediol, heat to dissolve, then add 1-3 parts of licorice extract, and 1-3 parts of Sophora flavescens root extract in sequence. After dissolving 1-3 parts of white willow bark extract into a light yellow liquid, add 5-12 parts of potassium azelayldiglycinate and 1-17 parts of purslane extract, and stir to obtain solution 3;

Add solution 2 to solution 3 and stir evenly to obtain an anti-acne composition.

Optionally, the sophora flavescens root extract, gentian extract, white willow bark extract, kava pepper extract, licorice extract, and purslane extract are all obtained by extraction with betaine citric acid.

A third aspect of the present invention provides an application of the anti-acne composition of the present invention in the preparation of anti-acne products.

Optionally, the anti-acne product is an anti-acne serum.

Beneficial effects: The present invention provides an anti-acne composition, which contains antibacterial ingredients, oil control and lightening acne mark ingredients, anti-inflammatory and soothing ingredients, repair ingredients, supramolecular solvents, Neosolue ^TM -Aqulio; targeting the stage of acne formation And the mechanism, multi-dimensional targets inhibit acne. First, anti-inflammatory and soothing ingredients are combined with repairing ingredients and antibacterial ingredients are delivered deep into the acne muscles by supramolecular solvents and Neosolue ^TM -Aqulio to unclog pores, relieve acne swelling and pain, regulate oil secretion, remove redness and repair, and fade acne marks, etc. Efficacy; Finally, it is compounded with Pionin, which has a bactericidal effect, to accelerate the re-establishment of microecological balance; ultimately, it can achieve short-term anti-inflammatory, redness and soothing to long-term oil control, repair, acne mark removal, and microecological balance, thereby improving acne-related skin problems. question.

Description of drawings

Figure 1 shows the trend of the per capita number of acne.

Figure 2 shows the trend of the per capita number of inflammatory papules.

Figure 3 shows the trend of the per capita number of pustules.

Figure 4 shows the change trend of Pillsbury grading scores.

Figure 5 is a chart showing the change trend of acne (red-green) value a* value.

Figure 6 shows the change trend in acne size and volume.

Figures 7-11 are all pictures of the human test results of the anti-acne essence.

Detailed ways

The present invention provides an anti-acne composition and its preparation method and application. In order to make the purpose, technical solution and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention and are not intended to limit the present invention.

At present, most acne products mainly use sterilization and anti-inflammation as their main functions to treat early-stage acne, but pay less attention to the later-stage skin repair and elimination of acne marks. In response to the above problems, it is important to provide a product with oil control, antibacterial, anti-inflammatory, repairing, and lightening acne marks.

Specifically, embodiments of the present invention provide an anti-acne composition, wherein, in parts by weight, the anti-acne composition includes: 0.05-0.1 parts of Pionin, 5-12 parts of Potassium Azelayldiglycinate, 1 part -3 parts Sophora flavescens root extract, 0.01-2 parts Gentian extract, 1-3 parts White Willow Bark extract, 1-3 parts Kava pepper extract, 1-3 parts Licorice extract, 1-17 parts Purslane extract, 1-5 parts glycerol glucoside, 1-45 parts polyol, 1-20 parts supramolecular solvent, 1-20 parts Neosolue ^TM -Aqulio.

Among them, Pionin and Potassium Azelayldiglycinate are used as antibacterial ingredients; Sophora flavescens root extract is used as an oil control and acne mark reducing ingredient; Gentian extract, white willow bark extract, kava pepper extract, and licorice extract , purslane extract as anti-inflammatory and soothing ingredients; glyceryl glucoside and polyol as repair ingredients.

This embodiment focuses on the stages and mechanisms of acne formation and uses multi-dimensional targets to inhibit acne. Firstly, supramolecular solvents are used to extract plants to obtain higher bioavailability and more stable plant extracts (i.e. plant extracts); secondly, plant extracts are combined with glycerol glucoside and azelayldiglycinate potassium by supramolecular solvents, Neosolue ^TM -Aqulio Delivered to the depths of acne muscles, it can achieve the effects of unclogging pores, relieving acne swelling and pain, regulating oil secretion, removing redness and repairing, and diluting acne marks. It is then combined with Pionin, which has bactericidal effect, to accelerate the re-establishment of microecological balance; finally It can achieve short-term anti-inflammation, redness and soothing to long-term oil control, repair, acne mark removal, and microecological balance, thereby improving acne-related problems. That is, betaine citric acid and Neosolue ^TM -Aqulio can act as penetration enhancers to deliver active ingredients deep into acne-prone skin.

In some embodiments, the polyol is at least one of butanediol and pentanediol. Wherein, the pentylene glycol is used as a preservative, and the butylene glycol is used as a solvent on the one hand, and a moisturizing agent on the other hand.

In some embodiments, the supramolecular solvent is betaine citric acid.

In some embodiments, the anti-acne composition consists of the following components in parts by weight: 0.05-0.1 parts of Pionin, 5-12 parts of azelayl diglycinate potassium, and 1-3 parts of Sophora flavescens root extract. 0.01-2 parts of gentian extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1 -5 parts glyceryl glucoside, 1-45 parts polyol, 1-20 parts betaine citric acid, 1-20 parts Neosolue ^TM -Aqulio.

Pionin, also called quaternary ammonium salt-73. Propionibacterium acnes is resistant to conventional fungicides, but due to the special mechanism of action of Pionin, only a very low dosage is needed to inhibit P. acnes and other bacteria and various fungi to a certain extent, and regulate the microecology Balance, inhibit the unbridled growth of acne, and improve acne symptoms.

Potassium azelayldiglycinate: It is a derivative of the famous anti-acne ingredient azelaic acid. Potassium azelayldiglycinate obtained through structural modification can be easily added to the formula, with better permeability and less irritation. It has been reduced a lot. It can inhibit skin oil secretion and peel off excess cutin. It has a good effect in regulating oil secretion. It has a stronger whitening effect and can effectively eliminate inflammation and fade acne marks.

Kava pepper extract: Kava pepper is a perennial upright shrub medicinal plant of the Piperaceae family. Its roots and rhizomes can be used as medicine. Its main medicinal ingredients are kavalactone, anesthetic capsaicin, anesthetic capsaicin, etc. Kava pepper extract has skin penetration, can inhibit fungi, reduce inflammation and analgesia, inhibit testosterone 5α-reductase activity, prevent excessive secretion of sebum, and reduce acne.

Purslane extract: Purslane is rich in flavonoids and polysaccharides, which has good antibacterial, anti-inflammatory, anti-inflammatory and analgesic effects. It can relieve skin sensitivity and inhibit the production and production of allergic mediators and inflammatory factors. Release to reduce damage to the skin from foreign objects.

Sophora flavescens root extract: The main active ingredient of Sophora flavescens root extract is matrine, which has broad-spectrum antibacterial properties and can balance oil secretion, dredge and shrink pores, fade acne marks, and promote the growth and repair of damaged skin.

Gentian extract: The root is mainly used for medicinal and cosmetic purposes. It can promote blood circulation, increase cell vitality, accelerate metabolism, and has antioxidant and anti-inflammatory activities.

Licorice extract: Licorice extract can be used in cosmetics for skin care, anti-inflammation, redness repair, and acne scar reduction. Licorice extract can effectively reduce melanin synthesis and enhance skin immunity. It can also resist inflammation and reduce oxidation rate. It can prevent skin sensitivity and soothe allergic or irritated skin.

White willow bark extract: White willow bark extract, also known as natural aspirin, its main active ingredients are salicin and dextran. Salicin is an oxidase inhibitor that can be turned into salicylic acid after metabolism by the human body. Because it contains plant flavonoids, it is gentler than salicylic acid when it directly acts on the skin. Salicin has the effect of exfoliating and removing acne, gently removes dead skin cells on the skin surface, accelerates the shedding of aging skin cells, regulates the physiological activity of the skin's stratum corneum, and makes the skin even and shiny.

Glyceryl glucoside: It is a glycoside compound composed of glucose and glycerol connected through glycosidic bonds. As resurrection grass essence, it can unlock aquaporin, enhance cell activity, and repair skin.

Betaine citric acid: Betaine citric acid not only has the moisturizing and moisture-locking effect of betaine, but also has the anti-inflammatory and bactericidal effect of citric acid. Betaine citric acid can accelerate the renewal of cuticles, improve the clogging of pores and horn plugs, and promote the metabolic growth of skin cells. . In its NaDESs (natural deep eutectic solvent) supramolecular system, due to the amphipathic nature of the supramolecular solvent, it can greatly improve the solubility of other active ingredients, effectively promote penetration, quickly open skin cell channels, and create smooth, healthy and good skin.

Neosolue ^TM -Aqulio: It can temporarily open the lipids between adjacent cells by affecting the lipids in the stable structure between keratinocytes. At the same time, the hydrophilic part of the structure can help the penetration of water-soluble active ingredients, thereby improving the skin absorption effect.

The embodiment of the present invention provides a method for preparing the anti-acne composition as described above, which includes the steps of: adding 0.05-0.1 parts of Pionin, 5-12 parts of potassium azelayldiglycinate, and 1-3 parts of Sophora flavescens. Root extract, 0.01-2 parts gentian extract, 1-3 parts white willow bark extract, 1-3 parts kava pepper extract, 1-3 parts licorice extract, 1-17 parts purslane extract , 1-5 parts of glycerol glucoside, 1-45 parts of polyol, 1-20 parts of supramolecular solvent, and 1-20 parts of Neosolue ^TM -Aqulio are mixed and stirred to obtain the anti-acne composition.

In some embodiments, the preparation method of the anti-acne composition specifically includes the steps of:

Mix 0.05-0.1 parts of Pionin, 1-3 parts of Kava pepper extract, 1-20 parts of betaine citric acid, and 1-25 parts of butylene glycol, and heat and dissolve to obtain solution 1;

Add 1-5 parts of glycerol glucoside, 5-15 parts of pentylene glycol, and 1-20 parts of Neosolue ^TM -Aqulio to solution 1 in sequence, and stir ultrasonically to obtain solution 2;

Mix 20-50 parts of deionized water, 0.01-2 parts of gentian extract, and 1-5 parts of butanediol, heat to dissolve, then add 1-3 parts of licorice extract, and 1-3 parts of Sophora flavescens root extract in sequence. After dissolving 1-3 parts of white willow bark extract into a light yellow liquid, add 5-12 parts of potassium azelayldiglycinate and 1-17 parts of purslane extract, and stir to obtain solution 3;

Add solution 2 to solution 3 and stir evenly to obtain an anti-acne composition.

In some embodiments, the sophora flavescens root extract, gentian extract, white willow bark extract, kava pepper extract, licorice extract, and purslane extract are all obtained by extraction with betaine citric acid. . The plant extracts used are extracted from betaine and citric acid. The active ingredients of the plant extracts extracted in this way have higher bioavailability and stability.

The embodiment of the present invention provides an application of the anti-acne composition as described above in preparing an anti-acne product.

In some embodiments, the anti-acne product is an anti-acne serum.

The anti-acne composition of this embodiment can exert the effects of dissolving keratin plugs, controlling oil, antibacterial, anti-inflammatory, soothing and removing redness, repairing and diluting acne marks. Through all-round anti-acne, it can achieve short-term anti-inflammatory and anti-acne treatment. Redness soothing to long-term oil control, repair, acne mark removal, microecological balance, thereby improving acne-related problems.

The present invention will be further described below through specific examples.

Comparative example 1

Add 0.05 parts of Pionin, 1 part of Kava pepper extract, and 25 parts of butylene glycol to the beaker, heat and dissolve them to obtain solution 1. Add 5 parts of glycerol glucoside, 5 parts of pentanediol, and 10 parts of Neosolue ^TM -Aqulio to solution 1 in sequence, and sonicate and stir evenly to obtain solution 2. Take another beaker, add 31.95 parts of deionized water and 2 parts of gentian extract into the beaker, heat and dissolve them, then add 2 parts of licorice extract, 1 part of Sophora flavescens root extract, and 1 part of white willow tree in sequence. After the skin extract is dissolved, add 10 parts of potassium azelayldiglycinate and 1 part of purslane extract, and stir evenly to obtain solution 3. Add solution 2 to solution 3 and stir evenly to obtain anti-acne composition 1.

Comparative example 2

Add 0.05 parts of Pionine, 1 part of kava pepper extract, 25 parts of butylene glycol, and 1 part of betaine citric acid into the beaker, and heat and dissolve them to obtain solution 1. Add 5 parts of glycerol glucoside, 5 parts of pentanediol, and 10 parts of Neosolue ^TM -Aqulio to solution 1 in sequence, and sonicate and stir evenly to obtain solution 2. Take another beaker, add 31.95 parts of deionized water and 2 parts of gentian extract into the beaker, heat and dissolve them, then add 2 parts of licorice extract, 1 part of Sophora flavescens root extract, and 1 part of white willow tree in sequence. After the skin extract is dissolved, add 10 parts of potassium azelayldiglycinate and 1 part of purslane extract and stir to obtain solution 3. Add solution 2 to solution 3 and stir evenly to obtain anti-acne composition 2.

Comparative example 3

Add 0.05 parts of Pionin, 1 part of kava pepper extract, 3 parts of betaine citric acid, and 12 parts of butylene glycol into the beaker, and heat and dissolve them to obtain solution 1. Add 5 parts of glycerol glucoside, 15 parts of pentanediol, and 10 parts of Neosolue ^TM -Aqulio to solution 1 in sequence, and sonicate and stir evenly to obtain solution 2. Take another beaker, add 31.95 parts of deionized water, 2 parts of gentian extract, and 3 parts of butylene glycol into the beaker. After heating and dissolving, add 2 parts of licorice extract and 1 part of Sophora flavescens root extract. After the substance and 1 part of white willow bark extract are dissolved, add 10 parts of potassium azelayldiglycinate and 1 part of purslane extract and stir evenly to obtain solution 3. Add solution 2 to solution 3 and stir evenly to obtain anti-acne composition 3.

Example 1

Add 0.05 parts of Pionin, 1 part of kava pepper extract, 5 parts of betaine citric acid, and 25 parts of butylene glycol into the beaker, and heat and dissolve them to obtain solution 1. Add 5 parts of glycerol glucoside, 5 parts of pentanediol, and 10 parts of Neosolue ^TM -Aqulio to solution 1 in sequence, and sonicate and stir evenly to obtain solution 2. Take another beaker, add 31.95 parts of deionized water and 2 parts of gentian extract into the beaker, heat and dissolve them, then add 2 parts of licorice extract, 1 part of Sophora flavescens root extract, and 1 part of white willow tree in sequence. After the skin extract is dissolved, add 10 parts of potassium azelayldiglycinate and 1 part of purslane extract, and stir evenly to obtain solution 3. Add solution 2 to solution 3 and stir evenly to obtain anti-acne composition 4.

Example 2

Add 0.05 parts of Pionin, 1 part of kava pepper extract, 5 parts of betaine citric acid, and 25 parts of butylene glycol into the beaker, and heat and dissolve them to obtain solution 1. Add 2 parts of glycerol glucoside, 8 parts of pentanediol, and 10 parts of Neosolue ^TM -Aqulio to solution 1 in sequence, and sonicate and stir evenly to obtain solution 2. Take another beaker, add 31.95 parts of deionized water and 2 parts of gentian extract into the beaker, heat and dissolve them, then add 2 parts of licorice extract, 1 part of Sophora flavescens root extract, and 1 part of white willow tree in sequence. After the skin extract is dissolved, add 10 parts of potassium azelayldiglycinate and 1 part of purslane extract, and stir evenly to obtain solution 3. Add solution 2 to solution 3 and stir evenly to obtain anti-acne composition 5.

Example 3

Add 0.05 parts of Pionin, 1 part of kava pepper extract, 5 parts of betaine citric acid, and 12 parts of butylene glycol into the beaker, and heat and dissolve them to obtain solution 1. Add 5 parts of glycerol glucoside, 15 parts of pentanediol, and 10 parts of Neosolue ^TM -Aqulio to solution 1 in sequence, and sonicate and stir evenly to obtain solution 2. Take another beaker, add 31.95 parts of deionized water, 2 parts of gentian extract, and 3 parts of butylene glycol. After heating and dissolving, add 2 parts of licorice extract and 1 part of Sophora flavescens root extract. After dissolving the substance and 1 part of white willow bark extract, add 10 parts of potassium azelayldiglycinate and 1 part of purslane extract and stir evenly to obtain solution 3. Add solution 2 to solution 3 and stir evenly to obtain anti-acne composition 6.

Application Examples 1-3 and Application Comparative Examples 1-3 are respectively Example 1-3 and Comparative Example 1-3 to prepare an anti-acne essence with a mass fraction of 4% of the anti-acne composition.

The anti-acne essence is made of the following raw materials and their parts by weight: 86.27 parts of deionized water, 0.8 parts of DC2501, 2 parts of dipropylene glycol, 0.15 parts of allantoin, 0.5 parts of glycerol glucoside, and 0.08 parts of Sclerotinia gel. , 4 parts of anti-acne composition, 4 parts of algal plant extract, 0.4 parts of cymene, 0.5 parts of Htsoft-56888, 0.2 parts of dipotassium glycyrrhizinate, 0.1 part of arginine, and 1 part of ceramide.

The preparation method of the anti-acne essence is as follows:

1. Add the formula amount of DC2501, dipropylene glycol, allantoin, glyceryl glucoside, and Sclerotinia jelly to deionized water in turn and homogenize, stir evenly, and heat to dissolve to obtain solution a;

2. Stir and cool down, add the formula amount of Acne 6, algal plant extract, cymene, 5668, dipotassium glycyrrhizinate, arginine, and ceramide to the solution a obtained in step 1 in sequence, stir evenly, and obtain the above of acne serum.

1. Antibacterial effect test:

This test will use the agar dilution method to mix and dissolve different concentrations of bacteriostatic agents in agar medium, and then inoculate bacteria. Based on the growth of bacteria, the lowest concentration of antibacterial substances that inhibit the growth of the test bacteria is determined. The lowest concentration that inhibits the growth of the test bacteria is the minimum inhibitory concentration (Minimal Inhibitory Concentration, MIC).

Table 1. Antibacterial effect of anti-acne composition

Group Experimental strains Minimum inhibitory concentration (MIC) Example 3 Propionibacterium acnes 2%

From the above data, it can be seen that the minimum inhibitory concentration of the composition against Propionibacterium acnes is 2%, indicating the antibacterial effect of the composition on acne.

2. Human efficacy test:

Preferably, the anti-acne essence prepared from the anti-acne composition of Embodiment 3 is subjected to a human efficacy test on the anti-acne essence:

Test site: Facial skin.

Test subjects: Select 30 subjects with mild, moderate and severe facial acne, aged 18-65 years old.

Test method: On the 0th day after applying the product, use a positioning film to delineate the acne lesions on the subject's face and count the number of acne, inflammatory papules, and pustules on the entire face for scoring; then the laboratory technicians will conduct the test The skin image analysis system Antera-3D collects images; on the 2nd, 5th, 7th, 14th, and 28th day after applying the product, the subjects were again collected images by the skin image analysis system Antera-3D.

The test results are shown in Figure 1-11. It can be seen from Figure 1-11:

After using Acne Treatment Essence D28:

1. The number of acne per capita decreased by 26.09% compared with the basic value, which is a significant difference;

2. The per capita number of inflammatory papules decreased by 33.06% compared with the basic value, which is a significant difference;

3. The per capita number of pustules decreased by 40.63% compared with the basic value, which is a significant difference;

4. Pillsbury grading score decreased by 24.82% compared with the basic value, which is a significant difference;

5. The (red-green) a* value of the acne area decreased by 24.10% compared with the basic value, which is a significant difference;

6. The volume of acne decreased by 80.95% compared with the base value, which is a significant difference.

7. Figures 7-11 show images collected at different times when subjects used anti-acne serum. It can be seen intuitively that the anti-acne serum has the effect of improving acne.

The above results indicate that the test sample has anti-acne efficacy.

Based on the above test results, it is shown that the anti-acne composition of this embodiment can repair the skin barrier, relieve skin inflammation, reduce redness caused by skin inflammatory reaction, and can be used in the field of skin barrier repair skin care products.

It should be understood that the application of the present invention is not limited to the above examples. Those of ordinary skill in the art can make improvements or changes based on the above descriptions. All these improvements and changes should fall within the protection scope of the appended claims of the present invention.

Claims (9)

1. An acne-removing composition is characterized by comprising the following components in parts by weight: 0.05-0.1 part of pride, 5-12 parts of potassium azenoyl diglycolate, 1-3 parts of kuh-seng root extract, 0.01-2 parts of gentian extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohols, 1-20 parts of supermolecular solvents and 1-20 parts of Neosolue ^TM -Aqulio。

2. The acne-removing composition according to claim 1, wherein the polyhydric alcohol is at least one of butylene glycol and pentylene glycol.

3. The acne-removing composition of claim 1, wherein the supramolecular solvent is betaine citric acid.

4. The acne-removing composition according to claim 1, wherein the acne-removing composition comprises the following components in parts by weight: 0.05-0.1 part of pride, 5-12 parts of potassium nonyldiglycolate, 1-3 parts of kuh-seng root extract, 0.01-2 parts of gentian extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohols, 1-20 parts of betaine citric acid and 1-20 parts of Neosolue ^TM Aqualio, 20-50 parts deionized water.

5. A method for preparing the acne-removing composition according to any one of claims 1 to 4, comprising the steps of: mixing 0.05-0.1 part of pride, 5-12 parts of potassium nonyldiglycolate, 1-3 parts of radix Sophorae Flavescentis extract, 0.01-2 parts of radix Gentianae extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract and 13 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohol, 1-20 parts of supermolecular solvent and 1-20 parts of neonolue ^TM -aqualio mixing, stirring to obtain the acne-removing composition.

6. The method for preparing the acne-removing composition according to claim 5, wherein the method for preparing the acne-removing composition specifically comprises the following steps in parts by weight:

mixing 0.05-0.1 part of Piaoning, 1-3 parts of kava extract, 1-20 parts of betaine citric acid and 1-25 parts of butanediol, and heating for dissolving to obtain solution 1;

sequentially mixing 1-5 parts of glyceroglycosides, 1-15 parts of pentanediol and 1-20 parts of Neosolue ^TM Aqualio is added to solution 1 and stirred ultrasonically to give solution 2;

mixing 20-50 parts of deionized water, 0.01-2 parts of gentian extract and 1-5 parts of butanediol, heating and dissolving, sequentially adding 1-3 parts of licorice extract, 1-3 parts of radix sophorae flavescentis extract and 1-3 parts of white willow bark extract, dissolving into light yellow liquid, adding 5-12 parts of potassium azedarachyl glycinate and 1-17 parts of purslane extract, and stirring to obtain solution 3;

adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition.

7. The method of preparing an anti-acne composition according to claim 5, wherein the kuh-seng extract, gentian extract, white willow bark extract, kava extract, licorice extract, purslane extract are all obtained by extraction with betaine citric acid.

8. Use of the anti-acne composition of any one of claims 1-5 for the preparation of an anti-acne product.

9. The use according to claim 8, wherein the anti-acne product is an anti-acne concentrate.