CN116688335A - Drivable medicine-releasing and sampling integrated capsule - Google Patents

Abstract

The application discloses a drivable drug release and sampling integrated capsule, and relates to the technical field of medical appliances. Can realize accurate position and accurate dosage of drug targeted release in human intestinal tracts and almost noninvasive tissue sampling. The capsule comprises a housing; the shell is provided with a first external thread and an internal thread with the same rotation direction; the tail part of the device is provided with a first medicine outlet, and the head part is provided with a sampling needle; a sleeve and a plunger are arranged in the shell; the sleeve is a cylinder with an opening at one end, and the plunger comprises a thread section and an optical axis section; the screw thread section is provided with a second external screw thread matched with the internal screw thread, the optical axis section stretches into the sleeve and can axially slide in the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose Chu Yaoqiang; a second medicine outlet is arranged on the side wall of the medicine storage cavity; the plunger can push the sleeve to move along the axial direction of the shell; when the sleeve moves to the bottom of the shell, the first medicine outlet is communicated with the second medicine outlet; the first external thread and the second external thread are both magnetic.

Description

Driven drug release and sampling integrated capsule

technical field

The present application relates to the technical field of medical devices, in particular to a drivable integrated capsule for drug release and sampling.

Background technique

Traditional treatment methods, such as surgery and drug therapy, have gradually exposed some shortcomings in long-term use. From the point of view of modern medical technology, these are relatively rough treatment methods. For example, surgery must open a wound on the skin, and it will also damage the tissues along the way. Traditional medication also makes the drug enter the blood circulation to act on the whole body, so it is a relatively inefficient treatment method.

In addition, most of the drugs ingested by swallowing pills or capsules are processed by the stomach and liver, and only a small part enters the blood circulation, and only a small part of this small part reaches the affected area in the end. Therefore, the amount of drugs that doctors arrange for patients is much higher than the amount of drugs that patients finally take effect. The excess amount of medicine inevitably brings various side effects to patients, especially some medicines with larger side effects.

With the development of technology, people began to pursue more sophisticated treatment methods. For example, minimally invasive surgery, or even non-invasive surgery, which minimizes the wound; and targeted drugs with precise effects, targeted delivery, etc. Capsules were born out of such needs. Thanks to its small enough overall size, targeted drug delivery can be achieved. The capsule can be equipped with some control mechanisms, such as miniature cameras, sampling needles, miniature sampling graspers, etc., to complete some fine operations.

For example, the capsule endoscope has been used in many hospitals. The patient swallows a capsule-sized endoscope, and the capsule endoscope completes a complete shooting of the entire length of the stomach and intestines along with the circulation of the stomach. examine. This kind of capsule endoscope can complete the inspection without the patient's perception, which greatly reduces the pain of the patient. However, the existing capsule endoscope can only be used for detection, cannot complete treatment, and cannot achieve precise positioning.

Contents of the invention

The embodiment of the present application provides a drivable integrated capsule for drug release and sampling, which can realize targeted release of drugs at precise positions and precise dosages in the human intestinal tract, and almost non-invasive tissue sampling.

To achieve the above purpose, on the one hand, the embodiments of the present application provide a drivable drug release and sampling integrated capsule, including a shell; the outer wall of the shell is provided with a first external thread, and the internal wall is provided with an internal thread The rotation direction of the first external thread and the internal thread is the same; the tail of the shell is provided with a first drug outlet, and the head is provided with a sampling needle; the shell is provided with a sleeve and a plunger; The sleeve is a cylinder with an opening at one end; the sleeve is slidably connected with the housing; the plunger includes a threaded section and an optical axis section; Two external threads, the optical axis section extends into the sleeve and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose a storage medicine chamber; the side wall of the medicine storage chamber is provided with a second medicine outlet; the plunger can push the sleeve to move axially along the housing; when the sleeve runs to the bottom of the housing , the first drug outlet communicates with the second drug outlet; both the first external thread and the second external thread are magnetic.

Further, the first drug outlet is a plurality of first radial holes arranged at the bottom of the side wall of the housing; the plurality of first radial holes are evenly distributed along the circumference of the housing; the second The drug outlet is a plurality of second radial holes arranged on the side wall of the sleeve; when the sleeve runs to the bottom of the housing, the second radial holes are connected with the first radial holes. There is a one-to-one correspondence with the positions of the holes.

Further, the outer side wall of the sleeve is provided with ribs extending in the axial direction, and the inner side wall of the housing is provided with sliding grooves matching the ribs.

Further, micro-thorns are provided on the tail end surface of the shell.

Further, an annular groove is provided on the inner side wall of the housing, and a boss matching the annular groove is provided on the head of the sleeve, and the boss can move along the axial direction of the annular groove. slide.

On the other hand, the embodiment of the present application also provides a second drivable drug release and sampling integrated capsule, which includes a shell; the outer wall of the shell is provided with a first external thread, and the inner wall is provided with an internal thread; the The rotation direction of the first external thread and the internal thread are the same; the tail of the shell is provided with a first drug outlet; the shell is provided with a sleeve and a plunger; the sleeve is a circle with an opening at one end barrel; the sleeve is slidably connected with the housing; the plunger includes a threaded section and an optical axis section; the threaded section is provided with a second external thread matching the internal thread, and the optical axis section It protrudes into the sleeve and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose a drug storage cavity; the drug storage cavity A second drug outlet is provided on the side wall; the plunger can push the sleeve to move axially along the housing; when the sleeve runs to the bottom of the housing, the first drug outlet and The second drug outlet is connected; the head of the plunger is provided with a drive rod; the head of the shell is provided with a limit sleeve; the end of the drive rod away from the plunger extends out of the limit sleeve and is connected Sampling pliers; both the first external thread and the second external thread are magnetic.

Further, the first drug outlet is a plurality of first radial holes arranged at the bottom of the side wall of the housing; the plurality of first radial holes are evenly distributed along the circumference of the housing; the second The drug outlet is a plurality of second radial holes arranged on the side wall of the sleeve; when the sleeve runs to the bottom of the housing, the second radial holes are connected with the first radial holes. There is a one-to-one correspondence with the positions of the holes.

Further, the outer side wall of the sleeve is provided with ribs extending in the axial direction, and the inner side wall of the housing is provided with sliding grooves matching the ribs.

Further, micro-thorns are provided on the tail end surface of the shell.

Further, an annular groove is provided on the inner side wall of the housing, and a boss matching the annular groove is provided on the head of the sleeve, and the boss can move along the axial direction of the annular groove. slide.

Compared with the prior art, the present application has the following beneficial effects:

1. The drug-releasing and sampling-integrated capsule that can be driven in the embodiment of the present application is aimed at the affected part of the gastrointestinal tract. By manipulating the external magnetic drive system, it can realize targeted and fixed-point drug release, thereby precisely controlling the amount of drug used, reducing side effects, and at the same time ensuring the treatment of the affected part. Get adequate medical treatment.

2. The drug release and sampling integrated capsule that can be driven in the embodiment of the present application has both drug release and sampling functions, and it can complete the two functions of drug release and tissue sampling once inserted.

3. The drug-releasing and sampling-integrated capsule that can be driven in the embodiment of the present application performs tissue sampling, which helps doctors better understand the condition of the affected area, and saves the patient from surgery, catheterization and guide wire, etc., and relieves the pain of the patient.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present application. Those skilled in the art can also obtain other drawings based on these drawings without creative work.

Fig. 1 is a schematic structural view of an integrated capsule for drug release and sampling that can be driven in an embodiment of the present application;

Fig. 2 is a schematic structural view of an actuatable drug release and sampling integrated capsule according to another embodiment of the present application.

Detailed ways

The following will clearly and completely describe the technical solutions in the embodiments of the application with reference to the drawings in the embodiments of the application. Apparently, the described embodiments are only some of the embodiments of the application, not all of them. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of this application.

In the description of this application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", The orientations or positional relationships indicated by "top", "bottom", "inner", "outer", etc. are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the application and simplifying the description, rather than indicating or implying References to devices or elements must have a particular orientation, be constructed, and operate in a particular orientation and therefore should not be construed as limiting the application.

In the description of this application, it should be noted that unless otherwise specified and limited, the terms "installation", "connection", and "connection" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection. Connected, or integrally connected; For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood in specific situations.

The terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, a feature defined as "first" and "second" may explicitly or implicitly include one or more of these features. In the description of the present application, unless otherwise specified, "plurality" means two or more.

Example 1:

Referring to FIG. 1 , an embodiment of the present application provides a drivable capsule for drug release and sampling. Its working environment is intestinal environment. The drivable drug release and sampling integrated capsule specifically includes a shell 1 , a sleeve 2 , a plunger 3 and a sampling needle 4 .

The shell 1 is a hollow cylindrical structure with a closed head and a bottom cover at the tail. Specifically, the outer wall of the housing 1 is provided with a first external thread 11, and the inner wall is provided with an internal thread 12; the first external thread 11 and the internal thread 12 have the same direction of rotation; On the outer wall, the internal thread 12 has only one section, which is arranged close to the head of the housing 1 . Both the first external thread 11 and the internal thread 12 are magnetic. In order to reduce the weight of the entire capsule, in the process of processing, the body of the shell 1 can be processed with plastic, and then the outer and inner parts of the plastic are nested with a magnetic material and processed with a first external thread 11 and an internal thread 12, so that Both the first external thread 11 and the internal thread 12 are magnetic. It should be noted that the housing 1 can also be processed directly with magnetic materials, so as to ensure that both the first external thread 11 and the internal thread 12 are magnetic. The specific processing method is selected according to the actual situation and is not limited here.

The end face of the tail of the shell 1 is provided with micro-thorns 13 , the top cover is provided with a through hole, and the through hole is provided with a sampling needle 4 , and the inner cavity of the sampling needle 4 communicates with the inner cavity of the shell 1 . In order to reduce components, the sampling needle 4 is integrally formed with the housing 1 . The bottom of the side wall is provided with a first drug outlet. The first drug outlets are a plurality of first radial holes 14 uniformly distributed along the circumference of the housing 1 .

The casing 1 is provided with a sleeve 2 and a plunger 3 . Wherein, the sleeve 2 is a cylinder with an opening at one end. The sleeve 2 is slidably connected with the shell 1 . Specifically, the outer wall of the sleeve 2 is provided with ribs extending in the axial direction, and the inner wall of the housing 1 is provided with a slide groove 15 matching with the ribs. Thereby, it is possible to prevent the sleeve 2 from turning when it slides. An annular groove 16 is also provided on the inner side wall of the housing 1 , and a boss 21 matching the annular groove 16 is arranged on the head of the sleeve 2 , and the boss 21 can slide along the axial direction of the annular groove 16 . Thereby, guiding properties can be enhanced. It should be noted that the annular groove 16 here may also be an undercut groove.

The plunger 3 includes a threaded section 31 and an optical axis section 32. The threaded section 31 is provided with a second external thread 33 matching the internal thread 12, and the second external thread 33 is also magnetic. The optical axis section 32 protrudes into the sleeve 2 and can slide along the axial direction of the sleeve 2 , and the bottom surface of the optical axis section 32 , the bottom surface of the sleeve 2 and the inner side wall of the sleeve 2 enclose the drug storage cavity 5 . The effect of medicine storage chamber 5 is equivalent to medicine storehouse, and liquid medicine is stored in it. A second medicine outlet is provided on the side wall of the medicine storage cavity 5 . The second drug outlet is a plurality of second radial holes 51 . The number of the second radial holes 51 is equal to the number of the first radial holes 14 .

The plunger 3 can push the sleeve 2 to move axially along the casing 1. When the sleeve 2 is not pushed to the bottom of the casing 1, the second radial hole 51 and the first radial hole 14 are staggered from each other, and the second radial hole 51 is blocked by the side wall of the housing 1, and the medicine in the medicine storage cavity 55 cannot flow out. When the sleeve 2 runs to the bottom of the housing 1, the positions of the second radial holes 51 and the first radial holes 14 correspond one-to-one. At this time, the medicine storage chamber 5 communicates with the outside, and the plunger 3 pushes the inside of the medicine storage chamber 5. The liquid medicine flows out. It should be noted that the capsule after installation is closed.

The working principle of Embodiment 1 of the present application is as follows:

The drug-sampling integrated capsule that can be driven and released in the embodiment of the present application is controlled by an external magnetic drive system, and the external magnetic drive system can apply forward and reverse rotating magnetic fields. The external magnetic drive system is a prior art and will not be described in detail here.

In order to reach the target position, the external magnetic control system applies a positive rotating magnetic field, the capsule rotates as a whole, and is screwed forward under the action of the first external thread 11 on the surface of the shell 1. At this time, the forward trend of the plunger 3 in the shell 1 Also be close to the direction of sampling needle 4, thus can not extrude liquid medicine at this moment. When the capsule moves to the target position as a whole, tissue sampling or drug release can be selected. It should be noted that the tissue sampling and drug release operations can be completed sequentially, and the two can be performed in no particular order, or only the tissue sampling or drug release operations can be completed.

If tissue sampling is performed, control the external magnetic drive system to adjust the rotation direction of the magnetic field, so that the sampling needle 4 faces the sampling area, and then the capsule is rotated forward until the sampling needle 4 penetrates the tissue, and then the magnetic field is rotated in the opposite direction, and the capsule is reversed. The rotating sampling needle 4 is withdrawn, and some tissues will remain in the sampling needle 4, thereby completing the sampling operation.

If the drug release operation is performed, the magnetic field needs to be reversely rotated. The capsule retreats to the nearby tissue wall, and the microthorns 13 at the bottom of the capsule penetrate into the tissue, so that the shell 1 is fixed. Then the magnetic field is continued to rotate in reverse, and the plunger 3 inside the capsule is screwed into the bottom. Due to the incompressibility of the liquid in the drug storage cavity 5 , the sleeve 2 will be pushed out first, and the second radial hole 51 on the sleeve 2 is aligned with the first radial hole 14 on the casing 1 . Then, the plunger 3 continues to screw in to the bottom, and slowly pushes the liquid medicine inside the medicine storage chamber 55 out of the capsule to complete the medicine release.

Example 2:

Referring to FIG. 2 , the embodiment of the present application also provides a drivable integrated capsule for drug release and sampling. Its working environment is intestinal environment. The difference between the embodiment 2 and the embodiment is only that in the embodiment 2, the sampling forceps 6 are used to replace the sampling needle 4 . Specifically, the head of the plunger 3 is provided with a drive rod 7, and the head of the housing 1 is provided with a limit sleeve 8, and the end of the drive rod 7 away from the plunger 3 extends out of the limit sleeve 8 and is connected to the sampling forceps 6. When the plunger 3. When moving in the axial direction, the driving rod 7 is driven, and then the sampling forceps 6 are driven to close to complete sampling. It should be noted that, in order to reduce components, the limiting sleeve 8 and the housing 1 are integrally formed.

The working principle of Embodiment 2 of the present application is as follows:

The drug sampling integrated capsule that can be driven and released in the embodiment of the present application is also controlled by an external magnetic drive system. The driving principle and drug release principle are the same as those in Example 1, and will not be described in detail here.

When tissue sampling is performed, the external magnetic drive system is controlled to adjust the rotation direction of the magnetic field, so that the sampling forceps 6 are opened and fully embedded in the tissue. At this time, the sampling forceps 6 contains a tissue block inside and is wrapped by tissue outside, and then the magnetic field is rotated in the opposite direction, and the plunger 3. The traction force transmitted to the sampling forceps 6 will cause the sampling forceps 6 to close first, and then, because the resistance between the sampling forceps 6 and the tissue decreases, the capsule will continue to be reversely driven, and the sampling forceps 6 will break away from the tissue to complete the sampling process.

The above are only specific implementation methods of this application, but the protection scope of this application is not limited thereto. Any changes or replacements within the technical scope disclosed in this application shall be covered within the protection scope of this application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.

Claims (10)

1. A drug-releasing and sampling integrated capsule that can be driven is characterized in that it comprises a shell; the outer wall of the shell is provided with a first external thread, and the inner wall is provided with an internal thread; the first external thread and the The rotation direction of the internal thread is the same; the tail of the shell is provided with a first drug outlet, and the head is provided with a sampling needle; the shell is provided with a sleeve and a plunger; the sleeve is a circular tube with an opening at one end. barrel; the sleeve is slidably connected with the housing; the plunger includes a threaded section and an optical axis section; the threaded section is provided with a second external thread matching the internal thread, and the optical axis section protruding into the inside of the sleeve and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose a drug storage cavity; the drug storage cavity A second drug outlet is provided on the side wall; the plunger can push the sleeve to move axially along the housing; when the sleeve moves to the bottom of the housing, the first drug outlet and The second drug outlet is connected; the first external thread and the second external thread are both magnetic. 2. The drivable drug release and sampling integrated capsule according to claim 1, wherein the first drug outlet is a plurality of first radial holes arranged at the bottom of the side wall of the housing; The first radial holes are uniformly distributed along the circumference of the housing; the second drug outlets are a plurality of second radial holes arranged on the side wall of the sleeve; when the sleeve runs to the When referring to the bottom of the housing, the positions of the second radial holes correspond to the positions of the first radial holes. 3. The driveable drug release and sampling integrated capsule according to claim 1, characterized in that, the outer wall of the sleeve is provided with ribs extending in the axial direction, and the inner wall of the shell is provided with a The chute that the rib is matched with. 4. The drivable drug release and sampling integrated capsule according to claim 1, characterized in that micro-thorns are provided on the end surface of the tail of the shell. 5. The driveable drug release and sampling integrated capsule according to claim 1, characterized in that, an annular groove is also provided on the inner side wall of the housing, and an annular groove corresponding to the annular groove is arranged on the head of the sleeve. A suitable boss, the boss can slide along the axial direction of the ring groove. 6. A drug-releasing and sampling integrated capsule that can be driven, characterized in that it includes a shell; the outer wall of the shell is provided with a first external thread, and the inner wall is provided with an internal thread; the first external thread and the The rotation direction of the internal thread is the same; the tail of the shell is provided with a first drug outlet; the shell is provided with a sleeve and a plunger; the sleeve is a cylinder with an opening at one end; the sleeve and The housing is slidably connected; the plunger includes a threaded section and an optical axis section; the threaded section is provided with a second external thread adapted to the internal thread, and the optical axis section extends into the inside of the sleeve and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose a drug storage cavity; the side wall of the drug storage cavity is provided with a second drug outlet; the plunger can push the sleeve to move axially along the housing; when the sleeve moves to the bottom of the housing, the first drug outlet and the second drug outlet Connected; the head of the plunger is provided with a drive rod; the head of the shell is provided with a limit sleeve; the end of the drive rod away from the plunger extends out of the limit sleeve and is connected to the sampling forceps; the first Both the external thread and the second external thread are magnetic. 7. The drivable drug release and sampling integrated capsule according to claim 6, wherein the first drug outlet is a plurality of first radial holes arranged at the bottom of the side wall of the housing; a plurality of The first radial holes are uniformly distributed along the circumference of the housing; the second drug outlets are a plurality of second radial holes arranged on the side wall of the sleeve; when the sleeve runs to the When referring to the bottom of the housing, the positions of the second radial holes correspond to the positions of the first radial holes. 8. The driveable drug release and sampling integrated capsule according to claim 6, characterized in that, the outer wall of the sleeve is provided with ribs extending in the axial direction, and the inner wall of the shell is provided with a The chute that the rib is matched with. 9 . The drivable drug release and sampling integrated capsule according to claim 6 , characterized in that micro-thorns are provided on the tail end surface of the shell. 10 . 10. The drivable drug release and sampling integrated capsule according to claim 6, characterized in that, an annular groove is provided on the inner side wall of the shell, and a ring groove is arranged on the head of the sleeve corresponding to the annular groove. A suitable boss, the boss can slide along the axial direction of the ring groove.