CN116650755A - A micro-injection pump management and control system and method - Google Patents

Abstract

The invention relates to a control system and method for a micro-injection pump. The system also includes: a processing unit for controlling the volumetric flow rate of fluid pushed by the first pump unit and the second pump unit; a mixing part for mixing at least two fluids. The diffusion of at least two fluids driven by the first pump unit and the second pump unit, and the concentration of the mixed fluid in the mixing part is adjusted under the control of the first pump unit and the second pump unit by the processing unit. For the present invention, multiple pump units can be used for mixed fluid supply, and the manual operation can be used as an automated process for micro-injection pumps, and the various structures provided reduce the fluid consumption caused by the combined use of multiple pump units. Diffusion, uneven concentration, less mixing time, etc.

Description

A micro-injection pump management and control system and method

technical field

The invention relates to the technical field of medical devices, in particular to a control system and method for a micro-injection pump.

Background technique

Micro-infusion pump (micro-pump for short) is a new type of pumping instrument, which can pump a small amount of liquid medicine into the body accurately, micro-quantity, uniformly and continuously. So that the drug can maintain effective blood drug concentration in the body. Microsyringe pumps, which can inject medical solutions to patients with high precision, have been used in the medical field for a long time. The micro-injection pump is configured to hold syringes of different sizes and types, and can accurately deliver the drug solution in the syringe by driving the piston pressing part for pressing the plunger of the syringe to press the plunger.

The reason why the micropumps in the prior art do not adopt the working mode of mixed injection of multiple syringes is that the mixed injection of multiple syringes is likely to cause fluctuations in fluid concentration. The main reasons for this fluctuation are: when multiple syringes are mixed and injected, the diffusion of the fluid at the mixing place will lead to uneven concentration of the mixed fluid; Affects the mixing of minor ingredients.

Chinese patent CN110772684B discloses a micro-injection pump for automatic dressing change and its working method, including infusion tube, multiple liquid-liquid converters, piston type water press, stepper motor, first and second dressing self-holding electromagnets , capillary and microcontroller, the microcontroller controls the action of the first and second dressing self-maintaining electromagnets, first opens the first branch, disconnects the second branch, uses the first liquid-liquid isolator to infuse, when the micro When the controller detects that the pressures at both ends of the first and second pressure sensing detection capillaries are equal, the infusion of the first liquid-liquid converter is completed. One branch, open the second branch, and use the second liquid-liquid converter for infusion; this patent can accurately detect the flow of liquid medicine in the infusion tube, and at the same time automatically deliver another medicine after one kind of medicine is infused , Realized the automatic control of dressing change, greatly reduced the workload of medical staff and ensured the continuity of infusion. But the defect of this patent is: still need medical personnel to carry out manual operation for the injection of mixed fluid, increased the workload of medical personnel. The injected fluid cannot be adjusted as the patient's condition changes, resulting in poor usability. Though this patent can carry out the replacement of medicinal liquid, for the medicinal liquid that needs to mix immediately, it still can't solve the problem that the workload of medical personnel is bigger.

Chinese patent CN103955236B discloses a fluid control system for medical testing equipment, which includes several small pumps for sucking liquid, and matching micro-control valves for controlling flow, and for transporting liquid and connecting the small pumps and micro-pumps The liquid feeding pipe of the control valve, through which the small pump is respectively connected to the liquid bottle containing the sample liquid and the micro control valve, is provided at the end nozzle of the liquid feeding pipe through the micro control valve for collecting and fixing the liquid feeding Tube pin plate. The system is compact in structure, easy to install and maintain, effectively improves its work efficiency in medical testing equipment, performs more targeted high-precision liquid sampling procedures, and can highly cooperate with other components of medical testing equipment for flexible integration and application. However, this patent cannot be used in micro-injection pumps, and is only used for liquid sample addition configuration. Although it has a high-precision detection function, it cannot improve work efficiency for micro-injection of patients, and cannot be used for micro-injection. Pump liquid distribution and concentration control.

In addition, on the one hand, due to differences in the understanding of those skilled in the art; The present invention does not possess the characteristics of these prior art, on the contrary, the present invention already possesses all the characteristics of the prior art, and the applicant reserves the right to add relevant prior art to the background technology.

Contents of the invention

Aiming at the deficiencies of the prior art, the present invention provides a micro-injection pump management and control system, which at least includes a first pump unit and a second pump unit. The first pump unit and the second pump unit are used to push at least two fluids for mixed injection. The system further includes: a processing unit for controlling the volumetric flow rate of fluid pushed by the first pump unit and the second pump unit; and a mixing unit for mixing at least two fluids. The mixing portion reduces diffusion of at least two fluids pushed by the first pump unit and the second pump unit in such a manner as to set a constricted flow portion, and in the processing unit to the first pump unit and the second pump unit The concentration of the mixed fluid in the mixing section is adjusted under the control of the pump unit. For the present invention, multiple pump units can be used for mixed fluid supply, and the operation that needs to be done manually can be used as an automated process for micro-injection pumps, and the various structures set reduce the fluid consumption caused by the combined use of multiple pump units. Diffusion, uneven concentration, less mixing time, etc. The above arrangement can also reduce the viscosity of the fluid to the pipeline, and avoid part of the fluid remaining in the pipeline. Overcome the adhesion of the pipeline to the fluid by continuous pumping, and prevent the influence of adhesion on the concentration of the fluid. The invention reduces the interference of the adsorption on the concentration by reducing the adsorption of the fluid to the pipeline wall.

According to a preferred embodiment, the high-velocity fluid in the first pump unit and the trace fluid in the second pump unit are mixed in the mixing part, and the first pump unit and the second pump A unit generates a fluid flow rate to produce a continuously variable concentration fluid at the mixing section under control by the processing unit. The mixing part set up in the present invention can realize the establishment of the concentration gradient of the fluid through the setting of the confluence pipe and the detection area, without the need for secondary dispensing, and can directly continuously adjust the concentration required by the patient.

According to a preferred embodiment, the processing unit is configured to: control the flow of the first fluid into the mixing part within a first period of time and quantitatively deliver the second fluid within a second period of time; the first pump unit The first fluid in the pump unit is pumped during the first time period, and the second pump unit produces a second fluid having a mirrored flow rate opposite to the first fluid during the second time period to achieve A flow rate control of the mixed fluid of the combination of the first fluid and the second fluid. In order to obtain a good therapeutic effect, it is very important to precisely control the concentration gradient of the mixed fluid. Unexpected or uncontrolled movement of fluids can alter the resulting concentration gradient. Due to the very slow flow rate of the fluid in the micropump, even very small fluid movements are insignificant against larger injection systems.

According to a preferred embodiment, the flow channel of the constricted flow part can be arranged at the intersection of the first pipeline and the second pipeline of the first pump unit and the second pump unit, or the constricted flow part The flow channels can be arranged on the first pipeline and the second pipeline. The flow path cross-sectional area of the constricted flow portion decreases as the first and second conduits extend toward the mixing section. The cross-sectional area of the junction of the first pipeline and the second pipeline is reduced to reduce fluid diffusion, thereby improving the concentration accuracy of the obtained mixed fluid.

According to a preferred embodiment, the first pump unit and the second pump unit send the first fluid and the second fluid into the mixing part in a manner of independently pushing fluids of different components to perform the mixed fluid Injection, wherein the total volume flow rate of the mixed fluid injected by the first pump unit and the second pump unit is kept constant or adjusted based on the judgment of the processing unit on the patient's need for medication.

According to a preferred embodiment, a junction of the first pipeline and the second pipeline is further provided with a confluence pipe, and the confluence pipe has a first confluence form and a second confluence form. When the pressure of the mixed fluid collected in the manifold to the restrictor of the mixing part reaches a threshold value, the restrictor is turned on so that the mixed fluid enters the patient, or the processing unit based on The required mixing conditions of at least two fluids control the transition of the flow restrictor between the conducting state and the blocking state.

According to a preferred embodiment, the restrictor restricts the delivery of the mixed fluid towards the patient, so that when at least two syringes push the fluid to be mixed to the manifold, the fluid to be mixed is at the manifold tube stacking. At least two injectors respectively push the fluid to be mixed into the manifold from the first pipeline and the second pipeline, and the fluid to be mixed pushed into the manifold causes the manifold to flow from the first manifold The morphology transitions to the second confluent morphology. The resistance of the syringe plunger can easily cause the plunger to crawl or engage in non-sliding friction, causing brief pauses in fluid flow. At this time, the expansion and contraction of the confluence pipe makes it have a tendency to change from the second confluence form to the first confluence form, so that the confluence pipe replenishes the suspended fluid and realizes continuous injection of fluid.

According to a preferred embodiment, the mixed fluid is pushed by the first pump unit and the second pump unit into the detection area between the manifold and the restrictor at a predetermined fluid flow rate, so that The detection area achieves the desired mixed fluid concentration, wherein the processing unit establishes a fluid concentration gradient by changing the fluid flow rates of the first pump unit and the second pump unit.

The present invention also relates to a method for controlling a micro-injection pump, the method comprising: pushing at least two fluids for mixed injection; controlling the volume flow of the fluid pushed by the first pump unit and the second pump unit; reducing the diffusion of at least two fluids pushed by the first pump unit and the second pump unit, and adjusting the mixed fluid in the mixing part under the control of the first pump unit and the second pump unit by the processing unit concentration.

According to a preferred embodiment, the method further includes: mixing the high-velocity fluid in the first pump unit and the trace fluid in the second pump unit in the mixing part, the first A pump unit and a second pump unit generate fluid flow rates to produce a continuously variable concentration fluid at the mixing section under control by the processing unit.

Description of drawings

Figure 1 is a schematic diagram of the simplified module connection relationship of a micro-injection pump management and control system according to a preferred embodiment of the present invention;

Fig. 2 is a simplified structural schematic diagram of a mixing section of a preferred embodiment provided by the present invention;

Fig. 3 is a simplified structural schematic diagram of a constricted flow part of a preferred embodiment provided by the present invention.

List of reference signs

1: processing unit; 2: first pump unit; 3: second pump unit; 4: mixing part; 5: manifold; 6: first pipeline; 7: second pipeline; 8: restrictor; 9 : detection area; 10: contraction flow part.

Detailed ways

A detailed description will be given below in conjunction with the accompanying drawings.

In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "vertical", "upper", "lower" and "horizontal" are based on the orientation or positional relationship shown in the drawings, and are only for It is convenient to describe the present invention and simplify the description, but does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and thus should not be construed as limiting the present invention.

In the description of the present invention, it should also be noted that, unless otherwise clearly specified and limited, the terms "installation", "installation", "connection" and "connection" should be understood in a broad sense, for example, it may be a fixed connection, It can also be a detachable connection, or an integral connection; it can be a mechanical connection, or it can be an electrical connection; it can be a direct connection, or an indirect connection through an intermediary, or an internal communication between two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention according to specific situations.

The term "fluid" generally refers to any flowable medium or composition, such as liquids, gases, vapors, supercritical fluids, combinations thereof, or ordinary meanings understood by those skilled in the art.

Example 1

The invention relates to a control system and method for a micro-injection pump to solve the technical problems existing in the micro-pump in the prior art. The system may comprise a microsyringe pump body having at least a first pump unit 2 and a second pump unit 3 . The first pump unit 2 and the second pump unit 3 are used to push at least two fluids for mixed injection. In this embodiment, the first pump unit 2 and the second pump unit 3 can be connected with driving motors to push the syringes on the first pump unit 2 and the second pump unit 3 for precise microinjection. The system also comprises a processing unit 1 for controlling the volumetric flow of fluid propelled by the first pump unit 2 and the second pump unit 3 .

Preferably, the processing unit 1 may be a general purpose computer comprising a memory for storing program instructions for controlling the first pump unit 2 and the second pump unit 3 . Preferably, the processing unit 1 may comprise a magnetic disk drive, an optical disk drive or other suitable components for reading instructions contained on a medium readable by the processing unit 1 to control the first pump unit 2 and the second pump unit 3 . Preferably, the processing unit 1 is also used for receiving, analyzing and displaying information transmitted from each detection unit. Preferably, the processing unit 1 can also be externally connected with respective input devices, including a display, a mouse, a keyboard or other suitable components known to those skilled in the art, for receiving and displaying operations of medical personnel. Preferably, the processing unit 1 controls the first pump unit 2 and the second pump unit 3 to output smooth and continuous fluid in a stable manner. As is known to those skilled in the art, the first pump unit 2 and the second pump unit 3 can generate a volume flow down to one nanoliter per minute. Preferably, the first pump unit 2 and the second pump unit 3 are controlled to generate a mixed fluid at the mixing end of the syringe. The mixed fluid has a ratio that changes continuously over time at the mixing end to create a continuous concentration gradient.

According to a preferred embodiment, the main body of the micro-injection pump further includes a display unit and a control panel. The control panel can be a non-touch screen button structure, so as to reduce failures and unusable situations of touch screen failure. The display unit is used for displaying information required to be displayed by the processing unit 1 . The micro syringe pump main body also includes an abnormality detection unit. The abnormality detection unit is used to detect the abnormality of the first pump unit 2 and/or the second pump unit 3 . The above-mentioned abnormal situation is, for example, a situation in which the installation of the syringe provided on the first pump unit 2 and/or the second pump unit 3 deviates. The present invention can detect the installation state of the syringe and the first pump unit 2 and/or the second pump unit 3 through the abnormality detection unit. Only when the detection state of the abnormality detection unit is normal, the processing unit 1 controls the first pump unit 2 and/or the second pump unit 3 to perform micro-injection. Preferably, the power source for injecting the syringe by the first pump unit 2 and the second pump unit 3 is also provided with a sensor. The sensor can be a pressure sensor or a sensor for detecting the output power of the power source, so as to obtain the pressure of the power source on the syringe or the output power of the power source. When the pressure sensor detects that the pressure of the power source on the syringe is too large, or when the output power of the power source is too large, it is determined that the pipeline from the syringe to the patient is blocked, resulting in restricted fluid flow. Preferably, the first pump unit 2 and the second pump unit 3 are provided with a decompression component, so as to perform decompression treatment when the processing unit 1 judges that the fluid flow in the pipeline is restricted. The pressure relief component can be, for example, a valve or orifice with a membrane attached to or placed inside the syringe, but is not limited thereto. Preferably, the various components and/or sensors are communicatively connectable. It should be noted that each component of the microinfusion pump can be supplied with current by an external power supply, and has a built-in power storage component (not shown), and can also supply current through the power storage component. The above-mentioned abnormality detection unit can be a photoelectric sensor, by detecting the position of the syringe or the position of the first pump unit 2 and/or the second pump unit 3 or whether the syringe is engaged with the first pump unit 2 and/or the second pump unit 3 to judge The installed state of the syringe. Preferably, the above abnormality detection unit can also directly detect the position of the first pump unit 2 and/or the second pump unit 3 by using a micro switch. The abnormality detection unit can also use a variety of sensors for detection, such as size detection sensors, etc., which will not be described in detail here.

When microfluid injection is performed on a patient through a micropump, due to the need to continuously deliver the fluid to the patient for a long period of time, when the delivered fluid concentration is small or the time required for continuous delivery is long, the respective injection fluids will be triggered. question. For example, when delivering a fluid with a low concentration, since the mixed fluid is a one-time configuration, the patient often needs a fluid with a low concentration at the beginning of the fluid injection, and after a certain amount of fluid is injected, the concentration needs to be increased to achieve optimal therapeutic effect. At this time, medical personnel need to replace the syringe and reconfigure the mixed fluid, resulting in wasting a lot of time, and even the suspension of the injection greatly reduces the effect of the medical fluid treatment. For another example, if the medical fluid remains in a mixed state for a long time, the drug effect may change. That is, some medical fluids need to be mixed and injected immediately, so that medical personnel need to mix and inject corresponding fluids in a fixed time period.

When a patient is injected with a microinjection pump, since the fluid injection process takes a long time, the volume of the injected fluid is small (such as nanoliter fluid) or the duration of the required injection is long , can lead to clinical problems with fluid injection. For example, during the injection of a certain fluid, since the required fluid flow rate is small and much smaller than the internal volume of the infusion tube, the tiny amount of fluid will remain in the infusion tube, that is, it may adhere to the inner wall of the infusion tube , resulting in unpredictable changes in the dose of fluid injected into the patient. For another example, when a patient needs to inject a mixed fluid, some fluids with special properties need to be mixed and injected in time, otherwise the therapeutic effect will be affected, and the micro-injection pump needs to work for a long time, and the mixed fluid may not be injected for a long time. changes in the nature of the human body. Based on the above defects, the present invention proposes a micro-injection pump management and control system capable of real-time mixing.

According to a preferred embodiment, the mixing ends of the first pump unit 2 and the second pump unit 3 are provided with a mixing part 4 for mixing fluids. It should be noted that the present invention lists the first pump unit 2 and the second pump unit 3 connected through the mixing part 4 and the pipeline, but it does not mean that the third pump unit or the fourth pump unit cannot be set on this basis . Preferably, the first pump unit 2 and the second pump unit 3 micro-pump the required fluid to the patient. Preferably, at least two syringes on the first pump unit 2 and the second pump unit 3 are connected to the mixing section 4 by tubing. Preferably, at least two syringes are fluidly delivered through separate lines and merge into the same line. Preferably, the mixing part 4 is detachably connectable to the syringe via a Luer connector.

According to a preferred embodiment, the mixing part 4 comprises a first pipeline 6 and a second pipeline 7 respectively connected to different syringes. A confluence pipe 5 is provided at the junction of the first pipeline 6 and the second pipeline 7 . The first pipeline 6, the second pipeline 7 and the manifold 5 form a "Y"-shaped structure. The confluence pipe 5 has a first confluence form and a second confluence form. Preferably, the confluence tube 5 is initially in the first confluence configuration and gradually transforms into the second confluence configuration after the fluid is injected. The first confluence form is a tightened state, and at this time the volume of the confluence pipe 5 is relatively small. The second confluence state is a relaxed state, and at this time the volume of the confluence pipe 5 is relatively large. The manifold 5 serves as a mixing chamber in which one or more fluids can be briefly mixed. Preferably, the flow restrictor 8 is arranged downstream of the manifold 5 . The restrictor 8 is, for example, a pressure valve or a pressure membrane. When the pressure of the mixed fluid collected in the manifold 5 reaches a threshold value, the restrictor 8 conducts to allow the mixed fluid to enter the patient's body. For example, when the opening pressure is between 0.17 MPa and 0.21 MPa, the fluid is allowed to flow out from the manifold 5 . Preferably, the restrictor 8 can also use a valve assembly that automatically switches between the conducting state and the blocking state. When the restrictor 8 is in the conduction state, the mixed fluid is allowed to flow from the manifold 5 into the body of the patient. When the restrictor 8 is in a closed state, it restricts the mixed fluid from flowing out of the manifold 5 . Preferably, the processing unit 1 controls the transition of the flow restrictor 8 between the conducting state and the blocking state based on the required mixing conditions of at least two fluids. The mixing conditions mentioned above refer to the required concentrations and volumes of the different fluids.

According to a preferred embodiment, before the mixed fluid is injected into the patient, the restrictor 8 is in a closed state. At least two syringes are prestored with fluids to be mixed at a certain concentration. Preferably, the restrictor 8 restricts the delivery line of the mixed fluid towards the patient so that the fluid to be mixed accumulates in the manifold 5 when at least two syringes push the fluid to be mixed to the manifold 5 . At this time, the confluence pipe 5 is in the first confluence configuration. Preferably, at least two injectors push the fluid to be mixed into the manifold 5 from the first line 6 and the second line 7 respectively. The fluid to be mixed pushed into the manifold 5 causes the manifold 5 to change from the first manifold configuration to the second manifold configuration. In the above case, the manifold 5 accommodates a certain amount of fluid pushed from at least two syringes, and gradually expands into a second manifold configuration. The second confluence form is the maximum volume of the confluence pipe 5 . Preferably, the manifold 5 maintains the second manifold configuration and has no tendency to return to the first manifold configuration. The manifold 5 allows at least two microfluidics to mix therein. Under the control of the processing unit 1, or under the continuous pressurized injection of at least two syringes, the restrictor 8 turns into a conduction state and no longer restricts the mixed fluid from entering the patient's body. The mixed fluid is thus injected into the patient during the continuous pumping of the microsyringe pump. The present invention transforms the traditional working process of mixing first and then injecting into pushing first, then mixing, and finally injecting through the first pump unit 2 and the second pump unit 3 . This saves medical personnel from performing multiple rationing of drug concentrations, and the mixing ratio can be automatically adjusted. The provided manifold 5 serves as a mixing chamber at the same time, so that at least two fluids can be mixed in real time during the injection process. The confluence tube 5 of the present invention is also used to supplement the stability of the fluid flow rate. When the micropump performs low-speed drug administration, it is easy to cause needle tip bleeding and coagulation blockage. The manifold 5 has a certain degree of flexibility, so that when the needle piston crawls and the flow rate fluctuates, the flow rate is supplemented by a certain deformation force, so that the injected mixed fluid has continuity. For example, when a patient needs to inject mixed fluids at an injection rate of 10ml/h, the resistance of the syringe plunger can easily cause the plunger to crawl or engage in non-sliding friction, resulting in a short pause in fluid flow. At this time, the expansion and contraction of the confluence pipe 5 makes it have a tendency to change from the second confluence form to the first confluence form, so that the confluence pipe 5 replenishes the suspended fluid and realizes the continuous injection of the fluid.

According to a preferred embodiment, a detection area 9 is also provided between the manifold 5 and the restrictor 8 . The detection area 9 can be analyzed by a detection unit. The fluid driven by at least two syringes in the manifold 5 undergoes passive mixing and sufficient interaction of the fluid components. Preferably, the detection unit may include acquiring measurements (eg concentration) of the mixed fluid by some data acquisition technique. The detection unit is operatively connected to the processing unit 1 for receiving and storing measurements obtained from the detection area 9 . The processing unit 1 is able to analyze the measurement results and present the results in a readable form to medical personnel. The above-mentioned detection area 9 is, for example, a micro-scale channel and/or a fluid mixing area with a microfluidic chip. Specifically, microfluidic chips are fabricated using solid substrates common in the field of micromachining, such as silicon dioxide substrates, glass, quartz, silicon or polysilicon, and other known substrates. At least two substrates constitute the detection zone 9 for monitoring of fluid parameters. Preferably, the processing unit 1 performs a specific analysis when the fluid passes through the detection zone 9 . The mixed fluid properly enters the detection area 9 at a predetermined fluid flow rate under the push of the micro-injection pump, so as to achieve the required fluid concentration in the detection area 9 . Preferably, the processing unit 1 establishes a fluid concentration gradient by changing the fluid flow rate. Preferably, the fluid concentration gradient varies with time. Preferably, the fluid concentration gradient is the change in fluid concentration in time along a certain period of time in time. For example, when the initial pumped pituitary hormone concentration required by a patient due to gastrointestinal bleeding is 0.2 U/min, if the patient’s symptoms are not relieved from bleeding, the concentration gradient needs to be continuously increased until 0.4 U/min. For conventional medical methods, it is necessary to configure 0.2U/min of pituitary hormone required for a certain period of time (for example, one hour), and pump it into the patient's body, and then observe the patient's physical state. If the injection has no obvious effect, a higher concentration of vasopressin is prepared and injected. As a result, a large amount of time of medical personnel is wasted, and various clinical situations of operational errors are prone to occur. The mixing unit 4 set up in the present invention, through the arrangement of the manifold 5 and the detection area 9, can realize the establishment of the concentration gradient of the fluid, without the need for secondary dispensing, and directly continuously adjust the concentration required by the patient. Preferably, the fluid concentration gradient can also be regarded as the concentration change with the volume change when the fluid flows through a space point. For example, after injecting a certain amount of mixed fluid, change its concentration before injecting. In order to obtain a good therapeutic effect, it is very important to precisely control the concentration gradient of the mixed fluid. Unexpected or uncontrolled movement of fluids can alter the resulting concentration gradient. Due to the very slow flow rate of the fluid in the micropump, even very small fluid movements are insignificant against larger injection systems. Likewise, the diffusion of dissolved chemicals in a fluid can change the concentration of a mixed fluid independent of fluid flow. This diffusive transport can be very important in micropumps, which have small spaces and very slow flow rates.

According to a preferred embodiment, the detection unit can detect the concentration of the mixed fluid in the detection area 9 by means of fluorescence monitoring of the mixed fluid. The concentration of the chemical contained in the mixed fluid is directly proportional to the intensity of the fluorescence. For the fluorescence detection described above, any type of light path known to those skilled in the art can be used. The excitation light source can be any suitable light source LS, such as a green He-Ne laser, a red diode laser, and the like. The detection unit may comprise a light detector for detecting fluorescence from and/or through the detection zone 9 where the reaction takes place. The detection unit may also use a photomultiplier tube. The detection unit can also use other optical configurations, such as fiber optics to transmit light from the excitation source to the detection region 9 and from the fluid in the detection region 9 to the photodetectors. The detection means of the above detection unit can also include phosphorescence, fluorescence variants (eg polarized fluorescence, fluorescence emission spectroscopy, etc.) and other non-optical techniques using sensors placed in the fluid flow (eg pH or other ion selective electrodes, etc.).

The layout of the manifold 5 and the detection area 9 is shown in the figure. The first pipeline 6 and the second pipeline 7 input two fluids. The first pump unit 2 and the second pump unit 3 are propelled through the first line 6 and the second line 7 respectively and mix at the fluid mixing junction. Preferably, the system may also include more than two pump units and pipelines for mixing more than two separated fluids of different components in the mixing part 4 . Preferably, the mixing part 4 can mix by means of diffusion or by a fluid pipeline structure with a special structure that generates eddy currents, preferably a Y-shaped junction. Preferably, the detection area 9 can be a return-type pipeline structure to allow enough time for detection.

According to a preferred embodiment, the first pump unit 2 and the second pump unit 3 enter the mixing part 4 with independent and different fluids for injection of the mixed fluid. Preferably, the total volume flow injected by the first pump unit 2 and the second pump unit 3 is kept constant during operation or varied based on the patient's medication requirements. Preferably, the flow ratios of the fluids delivered by the individual pump units can be controlled over time so that the concentration gradient of the mixture varies over time. Preferably, when the mixed fluid passes through the detection area 9, the detection unit detects the flowing mixed fluid at predetermined intervals. Measurements of the mixed fluid passing through the detection zone 9 can be plotted as a time and concentration dependent curve of the mixed fluid.

The reason why the micropumps in the prior art do not adopt the working mode of mixed injection of multiple syringes is that the mixed injection of multiple syringes is likely to cause fluctuations in fluid concentration. The main reasons for this fluctuation are: when multiple syringes are mixed and injected, the diffusion of the fluid at the mixing place will lead to uneven concentration of the mixed fluid; Affects the mixing of minor ingredients. For example, when the flow rate and the flow rate of the fluid in the input first pipeline 6 are greater than the flow rate and flow rate of the fluid in the second pipeline 7, the low flow rate flow will cause the fluid in the first pipeline 6 with high flow rate flow to flow into the second pipeline. The pipeline 7 causes part of the fluid to accumulate in the second pipeline 7 or the connection between the first pipeline 6 and the second pipeline 7, so that the fluid concentration is reduced. Specifically, the Y-junction comprises a first conduit 6 and a second conduit 7 with different fluids. The two fluids flow adjacently. At this time, the high-velocity fluid in the first pipeline 6 diffuses into the second pipeline 7 . When the fluid with a low flow rate in the second pipeline 7 is pushed into the mixing part 4, the diffused fluid is first pushed into the mixing part 4, so that the fluid mixing in the mixing part 4 is nonlinear and the injected fluid exists Minor error.

As mentioned above, when the fluid diffuses from one line to another line at the mixing junction, sudden changes in the concentration of the mixed fluid may be caused. At this point, fluid diffusion can be described by Fick's law:

Wherein, F is the fluid flow rate (mole/second), _Dc is the diffusion coefficient (centimeter square/second), ΔC is the concentration difference between the first pipeline 6 and the second pipeline 7, and Δx is the first pipeline 6 and The distance of the second pipeline 7. It can be obtained from the above formula that reducing the distance between the first pipeline 6 and the second pipeline 7 can reduce the occurrence of diffusion. Preferably, the cross-sectional area of the junction of the first pipeline 6 and the second pipeline 7 is reduced to reduce fluid diffusion. Preferably, the cross-sectional area of the first pipeline 6 and the second pipeline 7 is smaller than that of the mixing part 4 . Preferably, the cross-sectional area of the junction of the first pipeline 6 and the second pipeline 7 gradually decreases to form a constricted fluid flow.

According to a preferred embodiment, the first line 6 and the second line 7 comprise a flow channel with a constricted flow portion 10 to reduce fluid dispersion. The fluids in the first pipeline 6 and the second pipeline 7 are mixed by the mixing part 4 . Preferably, the flow rate of the fluid in the first pipeline 6 and the second pipeline 7 is varied, so as to adjust the concentration gradient of the patient's fluid at the mixing part 4 . In this embodiment, the flow channel of the constricted flow part 10 can be arranged at the intersection along the first pipeline 6 and the second pipeline 7, or the flow channel of the constricted flow part 10 can be provided at the first pipeline 6 and the second pipeline. Any part of the pipeline 7. The farther the flow path of the constricted flow portion 10 is from the mixing portion 4, the less effective the flow path of the constricted flow portion 10 is in reducing the diffusion effect of the fluid. Preferably, the flow channel cross-sectional area of the constricted flow portion 10 decreases as the first conduit 6 and the second conduit 7 extend toward the mixing portion 4 . The lines in the mixing section 4 can likewise be provided with a narrower cross-sectional area. Preferably, the diffusion effect can also be reduced by increasing the fluid resistance in the first pipeline 6 and/or the second pipeline 7 .

According to a preferred embodiment, as mentioned above, when the fluid in the first pipeline 6 and/or the second pipeline 7 remains stationary at the mixing part 4, the fluid from the second pipeline 7 and/or the first pipeline The fluid in path 6 can diffuse or flow into a stationary fluid. The static fluid mentioned above, for example, needs to adjust the concentration of the mixed fluid to temporarily stop the fluid delivery of a certain pump unit. The longer a stationary fluid remains stationary, the greater the amount of diffusing fluid and, therefore, the less precise the concentration. Thus, the amount of diffusing fluid can be reduced by reducing the time that the stationary fluid remains stationary. Preferably, the processing unit 1 is configured to: control the flow of the first fluid into the mixing part 4 during the first time period and quantitatively deliver the second fluid during the second time period. Preferably, the first time period can partially coincide with the second time period. Preferably, the processing unit 1 controls the quantitative mixing of different fluids in different time periods. Preferably, the system comprises a first pump unit 2 providing a high flow rate during a first period of time and a second pump unit 3 providing a trace amount of fluid during a second period of time. Preferably, the high flow rate fluid in the first pump unit 2 and the microfluid in the second pump unit 3 are mixed in the mixing part 4 . Preferably, the second time period can be started synchronously with the first time period. The specific numerical value of the quantitative supply depends on the chemical parameters of the mixed fluid to be configured. The first pump unit 2 and the second pump unit 3 are used to generate a fluid flow rate to achieve a continuously variable concentration fluid at the mixing section 4 . The first pump unit 2 and the second pump unit 3 can continuously generate fluid with a constant total volume flow. The first fluid in the first pump unit 2 is pumped during the first time period, and the second pump unit 3 produces a mirrored flow rate during the second time period, so as to control the combined flow rate of the first fluid and the second fluid. Since the relative flow velocity of the flow of the first pump unit 2 and the second pump unit 3 is not zero at any time, when any one of the fluid in the first pipeline 6 or the second pipeline 7 remains static, there is The minimum time period, such that fluid diffusion effects are reduced. While achieving the above effects, the control of the concentration gradient of the mixed fluid over time is simultaneously realized. The aforementioned mirror image flow rate means that: the flow rate of the first fluid and the flow rate of the second fluid are in a mirror image complementary state, that is, the sum of the flow rates of the first fluid and the second fluid is greater than zero. The technical effect of such an arrangement is that the fluid requiring a high flow rate is delivered to the mixing part 4 within the first time period, and a small amount of fluid is delivered within the second time period. Traditional micro-dose preparation is by dosing the components of the fluid and by mixing two or more successive fluids to form a mixed fluid for injection. Medical personnel need to configure a certain amount of mixed fluid in advance, and then inject the mixed fluid through a micro-infusion pump. For the present invention, multiple pump units can be used for mixed fluid supply, and the operation that needs to be done manually can be used as an automated process for micro-injection pumps, and the various structures set reduce the fluid consumption caused by the combined use of multiple pump units. Diffusion, uneven concentration, less mixing time, etc. The above arrangement can also reduce the viscosity of the fluid to the pipeline, and avoid part of the fluid remaining in the pipeline. Overcome the adhesion of the pipeline to the fluid by continuous pumping, and prevent the influence of adhesion on the concentration of the fluid. The invention reduces the interference of the adsorption on the concentration by reducing the adsorption of the fluid to the pipeline wall. For the mixed injection of multiple types of fluids, if one or more of the multiple types of fluids to be mixed needs to be mixed with a small amount of injection, and the other or more fluids need to be more For high-capacity mixing, it is difficult for conventional microsyringe pumps to maintain the flow of different kinds of fluids pushed from different syringes at the beginning of mixing of several kinds of fluids. That is, when the required flow rate of one or more fluids is too large, while the required flow rate of another or more fluids is too small, it will cause the mixed fluid formed by the micro-injection pump to be difficult to perform continuous mixing work. . The first time period and the second time period set by the present invention supply and mix the high-capacity fluid and the microfluid respectively. Compared with the traditional quantitative mixing of several fluids, the invention can reduce the workload of medical personnel, realize the mixing of fluids through an automated process, and solve the problem of uncontrollable flow rate caused by mechanical mixing. For example, when one or more of the fluids is required in a small amount, the continuous mixed fluid will greatly reduce its exit flow rate, that is, the high-capacity fluid needs to cooperate with the injection of a small amount of fluid to reduce the overall injection of the mixed fluid. This leads to various problems such as low injection accuracy of the mixed fluid. The present invention quantitatively mixes the fluids required by different volumes according to their respective time periods, and provides continuous controllable flow rate and high-precision mixed fluids through the cooperation of multiple pump units, restrictors and constricted flow parts 10.

Specifically, in the case that the concentration of the fluid injected into the patient needs to be changed, the adjustment of the fluid concentration can be realized by adjusting the first pump unit 2 and the second pump unit 3 . The restrictor 8 can be in a closed state to pump the mixed fluid into the patient after the concentration of the mixed fluid in the manifold 5 reaches the corresponding requirement, or continuously change the fluid concentration based on the concentration gradient of the fluid until the threshold required by the patient is reached. For example, a mixture of nitroglycerin and sodium chloride solution is infused to relieve angina in patients. The mixing rate of the initial injection was 10 μg/min, and then increased by 5–10 μg every 5 to 10 minutes, with a maximum of 200 μg/min. In this regard, the mixed injection of the present invention can realize the adjustment of concentration and flow rate by adjusting the injection amount of nitroglycerin. For another example, when injecting lidocaine into a patient, it needs to be injected at a rate of 25 mg/min as the initial injection, and the injection is suspended after 2 to 3 minutes, and if necessary, it is injected at a rate of 50 mg every five minutes for one hour. The total amount is within 300mg. Finally, the injection was maintained at a rate of 1 mg to 4 mg/min. For this injection method, repeated operations are required for the traditional medical personnel to perform the configuration injection process to complete micro-pumping. However, for the present invention, the above-mentioned discontinuous operations can be completed only after automatic operations such as mixing, injection, and pause are performed. The invention can realize continuous concentration adjustment of mixed fluid and adjustment of pumping rate and time.

Throughout the text, the features introduced by "preferably" are only optional, and should not be interpreted as having to be set. Therefore, the applicant reserves the right to waive or delete relevant preferred features at any time. It should be noted that the above-mentioned specific embodiments are exemplary, and those skilled in the art can come up with various solutions inspired by the disclosure of the present invention, and these solutions also belong to the scope of the disclosure of the present invention and fall within the scope of this disclosure. within the scope of protection of the invention. Those skilled in the art should understand that the description and drawings of the present invention are illustrative rather than limiting to the claims. The protection scope of the present invention is defined by the claims and their equivalents. The description of the present invention contains a number of inventive concepts, such as "preferably", "according to a preferred embodiment" or "optionally" all indicate that the corresponding paragraph discloses an independent concept, and the applicant reserves the right to propose a division based on each inventive concept right to apply.

Claims (10)

1. A microinjection pump control system, characterized in that it comprises at least a first pump unit (2) and a second pump unit (3), wherein the first pump unit (2) and the second pump unit (3) ) for pushing at least two fluids for mixed injection, wherein the system also includes: A processing unit (1), used for controlling the volumetric flow rate of fluid pushed by the first pump unit (2) and the second pump unit (3); A mixing section (4) for mixing at least two fluids, wherein, The mixing part (4) reduces diffusion of at least two fluids pushed by the first pump unit (2) and the second pump unit (3) in a manner of setting a constricted flow part (10), and in the The processing unit (1) adjusts the concentration of the mixed fluid in the mixing part (4) under the control of the first pump unit (2) and the second pump unit (3). 2. The microinjection pump management and control system according to claim 1, characterized in that, the first fluid in the first pump unit (2) and the second fluid in the second pump unit (3) are Mixing in the mixing section (4), the first pump unit (2) and the second pump unit (3) generate a fluid flow rate to be generated at the mixing section (4) by the control of the processing unit (1) Continuously variable concentration fluid. 3. The micro-injection pump management and control system according to claim 1 or 2, characterized in that the processing unit (1) is configured as: Controlling the flow of the first fluid into the mixing part (4) during a first period of time and quantitatively delivering the second fluid during a second period of time; the first fluid in the first pump unit (2) The fluid is pumped during the first period of time, and the second pump unit (3) generates a second fluid with a mirror image flow rate opposite to the first fluid during the second period of time to achieve the The flow rate of the mixed fluid of the combination of the first fluid and the second fluid is controlled. 4. The micro-injection pump management and control system according to any one of claims 1-3, characterized in that, the flow channel of the constricted flow part (10) can be set in the first pump unit (2) and the second pump unit (2) the junction of the first line (6) and the second line (7) of the pump unit (3), or The flow channel of the constricted flow part (10) can be arranged on the first pipeline (6) and the second pipeline (7), wherein, The flow channel cross-sectional area of the constricted flow part (10) decreases as the first pipeline (6) and the second pipeline (7) extend toward the mixing part (4). 5. The micro-injection pump management and control system according to any one of claims 1-4, characterized in that, the first pump unit (2) and the second pump unit (3) independently push fluids of different components sending the first fluid and the second fluid into the mixing part (4) for injection of the mixed fluid, wherein, The total volume flow rate of the mixed fluid injected by the first pump unit (2) and the second pump unit (3) is kept constant or adjusted based on the judgment of the processing unit (1) on the patient's need for medication. 6. The micro-injection pump management and control system according to any one of claims 1-5, characterized in that, the junction of the first pipeline (6) and the second pipeline (7) is provided with a confluence A pipe (5), the confluence pipe (5) has a first confluence form and a second confluence form, wherein, When the pressure of the mixed fluid collected in the manifold (5) on the restrictor (8) of the mixing part (4) reaches a threshold value, the restrictor (8) conducts to make the the mixed fluid enters the patient, or The processing unit (1) controls the transition of the flow restrictor (8) between the conducting state and the blocking state based on the required mixing conditions of at least two fluids. 7. The microinjection pump management and control system according to any one of claims 1 to 6, characterized in that, the restrictor (8) restricts the delivery of the mixed fluid toward the patient, so that when at least two syringes are about to When the mixed fluid is pushed to the manifold (5), the fluid to be mixed is accumulated in the manifold (5), wherein, At least two injectors respectively push the fluid to be mixed into the manifold (5) from the first pipeline (6) and the second pipeline (7), and push the fluid to be mixed into the manifold (5) Fluid causes said manifold (5) to transition from said first manifold configuration to said second manifold configuration. 8. The micro-injection pump management and control system according to any one of claims 1-7, characterized in that the mixed fluid is driven by the first pump unit (2) and the second pump unit (3) at a predetermined rate The fluid flow rate enters the detection area (9) between the manifold (5) and the restrictor (8), so as to achieve the required mixed fluid concentration in the detection area (9), wherein, The processing unit (1) establishes a fluid concentration gradient by changing the fluid flow rates of the first pump unit (2) and the second pump unit (3). 9. A micro-injection pump control method, characterized in that the method comprises, pushes at least two fluids for mixed injection; controlling the volumetric flow rate of fluid pushed by the first pump unit (2) and the second pump unit (3); Diffusion of at least two fluids pushed by said first pump unit (2) and second pump unit (3) is reduced in such a way that a constricted flow portion (10) is provided, and in the treatment unit (1) to said second pump unit The concentration of the mixed fluid in the mixing part (4) is adjusted under the control of a pump unit (2) and a second pump unit (3). 10. The microinjection pump control method according to claim 9, characterized in that the method further comprises: The first fluid in the first pump unit (2) and the second fluid in the second pump unit (3) are mixed in the mixing part (4), and the first pump unit (2) and A second pump unit (3) generates a fluid flow rate to produce a continuously variable concentration of fluid at said mixing section (4) controlled by said processing unit (1).