CN116636619A - A collagen peptide composition for improving immunity and anti-aging - Google Patents

Abstract

The invention discloses a collagen peptide composition for improving immunity and resisting aging. Belonging to the technical field of health-care food. The composition comprises the following components in parts by weight: 55-70 parts of collagen peptide, 35-50 parts of whey protein, 20-30 parts of haematococcus pluvialis, 10-25 parts of hericium erinaceus polysaccharide and 3-10 parts of spina date seed. Compared with the prior art, the invention has the beneficial effects that: (1) The collagen peptide composition adopts natural raw materials, has scientific formula and rich nutrition, and has the functions of maintaining beauty and keeping young, delaying aging and improving immunity. (2) The components of the composition are matched with each other, and the composition has synergistic effect, so that the absorption and utilization of collagen peptide can be promoted.

Description

A collagen peptide composition for improving immunity and anti-aging

technical field

The invention relates to the technical field of health food, in particular to a collagen peptide composition for improving immunity and anti-aging.

Background technique

Collagen is an extracellular protein, which is the most abundant protein in the human body, accounting for more than 30% of the total protein in the body. Collagen is rich in amino acids such as glycine, proline, and hydroxyproline needed by the human body, and is the most important component of the extracellular matrix. In the composition of human skin, 70% is composed of collagen. When collagen is insufficient, not only skin and bone problems will occur, but internal organs will also be adversely affected. In other words, collagen is an indispensable and important component for maintaining normal body activities. It is also a substance that keeps the body young and prevents aging.

Collagen is a macromolecular protein and cannot be directly absorbed by the human body. Collagen peptide is a kind of product that is produced from fresh animal tissues rich in collagen (including skin, bone, tendon, tendon, scale, etc.) through extraction, hydrolysis, and refining, with a relative molecular mass of less than 10,000 Da. Collagen peptides have high digestibility and absorption. Generally speaking, the smaller the molecular weight, the better the solubility and the better the absorption.

Most of the existing collagen peptides are used as health care products, which have many benefits for the human body. Due to their wide coverage, this makes them have no main effect. At present, most of the methods of compounding various substances are used to achieve the effect of promoting the absorption of various substances and compounding functions, but the compounding effect is not ideal.

To sum up, how to provide a multifunctional collagen peptide composition with good composite effect is an urgent problem to be solved by those skilled in the art.

Contents of the invention

In view of this, the present invention provides a collagen peptide composition for improving immunity and anti-aging.

In order to achieve the above object, the present invention adopts the following technical solutions:

A collagen peptide composition for improving immunity and anti-aging, comprising the following components in parts by mass: 55-70 parts of collagen peptide, 35-50 parts of whey protein, 20-30 parts of Haematococcus pluvialis, 10-25 parts of Hericium erinaceus polysaccharide and 3-10 parts of jujube seed.

Beneficial effects obtained: Collagen is a kind of natural protein with unique structure, which is widely distributed in cartilage, bone, skin, hair, tendon, blood vessel and other tissues, and plays the role of protecting the body and supporting organs. Collagen peptides can provide the necessary nutrients for skin regeneration, promote skin repair, and provide strong support for the dermis, thereby keeping the skin elastic.

Whey protein is a kind of protein extracted from milk. Its physiological function is mainly to supply growth, participate in the formation of enzymes, hormones and some vitamins, regulate the physiological functions of the body, and enhance immunity.

Haematococcus pluvialis is a single-celled green algae in freshwater, which can produce a large amount of carotenoids under certain conditions, most of which are astaxanthin. Astaxanthin has a strong ability to scavenge free radicals and plays an important role in human health.

Hericium erinaceus polysaccharide is rich in a variety of nutrients beneficial to the human body, which can stimulate and enhance the immune function of the human body, so that the body can better resist the invasion of pathogens and prevent the occurrence of various diseases. In addition, it also has the function of anti-oxidation.

The components of jujube seed are complex, but most of them have been identified. Among them, the content of jujube seed saponins A and B, total flavonoids and fatty oil are relatively large, and there are also alkaloids, vitamins and trace elements. The efficacy of Suanzaoren is generally recognized by everyone, and the clear pharmacological effects are mainly sedative and hypnotic effects, and anti-anxiety and depression effects.

Further, a collagen peptide composition for improving immunity and anti-aging includes the following components in parts by mass: 65 parts of collagen peptide, 44 parts of whey protein, 28 parts of Haematococcus pluvialis, Hericium erinaceus 13 parts of polysaccharide and 5 parts of jujube seed.

Further, the collagen peptide is tilapia skin collagen peptide.

Further, the molecular weight of the collagen peptide is 1200-1500 Daltons.

A collagen peptide health food for improving immunity and anti-aging, comprising the above-mentioned composition.

It should be noted that when using the composition of the present invention to prepare health food, other functional ingredients such as elastin peptides, enzymes, natural substance extracts, fruit and vegetable powders, probiotics, etc. can also be added to the health food.

It can be combined with an acceptable carrier, diluent or flavoring agent through the existing preparation process to make a health food for oral preparation.

Further, the oral preparation may be powder, pill, tablet, granule, capsule or liquid preparation.

Further, the health food contains more than 50% of the composition.

It can be seen from the above-mentioned technical scheme that compared with the prior art, the beneficial effects obtained by the present invention are as follows: (1) The collagen peptide composition of the present invention adopts natural raw materials, has a scientific formula, is rich in nutrition, and has the functions of beautifying the skin and delaying aging. , Improving the role of immunity. (2) The components of the composition of the present invention cooperate with each other to synergize and promote the absorption and utilization of the collagen peptide.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

The medicaments required by the present invention are conventional experimental medicaments, which are purchased from commercially available channels; the unmentioned experimental methods are conventional experimental methods, and will not be repeated here.

Example 1

A collagen peptide composition for improving immunity and anti-aging, comprising the following components by mass: 55 parts of collagen peptide, 35 parts of whey protein, 20 parts of Haematococcus pluvialis, and 10 parts of Hericium erinaceus polysaccharide And jujube seed 3 parts.

The collagen peptide is tilapia skin collagen peptide.

Example 2

A collagen peptide composition for improving immunity and anti-aging, comprising the following components by mass: 70 parts of collagen peptide, 50 parts of whey protein, 30 parts of Haematococcus pluvialis, and 25 parts of Hericium erinaceus polysaccharide And 10 parts of Suanzaoren.

The collagen peptide is tilapia skin collagen peptide.

Example 3

A collagen peptide composition for improving immunity and anti-aging, comprising the following components by mass: 65 parts of collagen peptide, 44 parts of whey protein, 28 parts of Haematococcus pluvialis, and 13 parts of Hericium erinaceus polysaccharide And 5 parts of Suanzaoren.

The collagen peptide is tilapia skin collagen peptide.

Comparative example 1

A collagen peptide composition for improving immunity and anti-aging, comprising the following components by mass: 75 parts of collagen peptide, 30 parts of whey protein, 33 parts of Haematococcus pluvialis, and 5 parts of Hericium erinaceus polysaccharide And jujube seed 1 part.

The collagen peptide is tilapia skin collagen peptide.

Comparative example 2

A collagen peptide composition for improving immunity and anti-aging, comprising the following components by mass: 50 parts of collagen peptide, 55 parts of whey protein, 15 parts of Haematococcus pluvialis, and 30 parts of Hericium erinaceus polysaccharide And 11 parts of Suanzaoren.

The collagen peptide is tilapia skin collagen peptide.

Comparative example 3

A collagen peptide composition for improving immunity and anti-aging, comprising the following components by mass: 80 parts of collagen peptide, 15 parts of whey protein, 18 parts of Haematococcus pluvialis, and 30 parts of Hericium erinaceus polysaccharide And Suanzaoren 15 parts.

The collagen peptide is tilapia skin collagen peptide.

Comparative example 4

A collagen peptide composition for improving immunity and anti-aging, comprising the following components in parts by mass: 65 parts of collagen peptide, 44 parts of whey protein, and 28 parts of Haematococcus pluvialis.

The collagen peptide is tilapia skin collagen peptide.

Comparative example 5

A collagen peptide composition for improving immunity and anti-aging, comprising the following components in parts by mass: 65 parts of collagen peptide, 44 parts of whey protein, and 5 parts of jujube seed.

The collagen peptide is tilapia skin collagen peptide.

Experiment 1

The anti-aging effects of the compositions of Examples 1 to 3 and Comparative Examples 1 to 5 were studied on the natural aging mouse model, and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione Glycerin peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) were detected.

90 16-month-old ICR female mice, weighing 33-40 g, were selected and randomly divided into 9 groups (ie, the control group and the experimental group). There was no significant difference in the condition of the mice among the groups. Dosing is as follows:

Experimental group 1 was administered the composition (0.1g/kg) of Example 1;

Experimental group 2 was administered the composition (0.1g/kg) of Example 2;

Experimental group 3 was administered the composition (0.1g/kg) of embodiment 3;

Experimental group 4 was given the composition (0.1g/kg) of Comparative Example 1;

Experimental group 5 was given the composition (0.1g/kg) of Comparative Example 2;

Experimental group 6 was administered the composition (0.1g/kg) of comparative example 3;

Experimental group 7 was administered the composition (0.1g/kg) of Comparative Example 4;

Experimental group 8 was given the composition (0.1g/kg) of comparative example 5;

The control group was intragastrically administered the same amount of normal saline.

After continuous administration for 60 days, the eyeballs were removed to take serum samples, and kits were used to detect the content of MDA, SOD, GSH-Px and T-AOC in serum.

The experimental results are shown in Table 1.

Table 1 The results of the mouse anti-aging experiment

MDA (nmol/ml) SOD(U/ml) GSH-Px(U/ml) T-AOC(U/ml) control group 26.58 205.41 207.77 11.94 Experimental group 1 15.89 357.88 522.15 23.01 Experimental group 2 16.29 348.22 516.78 23.55 Experimental group 3 13.21 360.58 542.33 24.89 Experimental group 4 20.77 281.53 306.74 16.02 Experimental group 5 22.31 263.52 352.56 17.35 Experimental group 6 19.11 274.55 325.69 16.78 Experimental group 7 20.45 280.06 311.03 15.44 Experimental group 8 20.31 277.09 295.43 15.88

The above results show that, compared with the control group, the composition prepared by the present invention significantly reduces the MDA content in the mouse serum, significantly increases the SOD and GSH-Px activities, and significantly increases the T-AOC level. It shows that the composition of the present invention can effectively anti-aging.

Experiment 2

The compositions of Examples 1-3 and Comparative Examples 1-5 were tested.

Objects in each group: 50 volunteers, aged 35-60, female. Symptoms are: sagging, oily skin, enlarged pores, and dull complexion. There were no significant differences in skin condition between the groups.

The test subject took the composition of the embodiment or the comparative example every day, 2 g each time, once a day. Evaluation after one month.

evaluation standard:

(1) Significant effect: the skin is more hydrated, the oil output is significantly reduced, the enlarged pores are significantly improved, and the whiteness is increased by 30%;

(2) Effective: the skin is moisturized, the oil production is reduced, the enlarged pores are slightly improved, and the whiteness is increased by 10%;

(3) Ineffective: no obvious improvement or aggravation of symptoms before and after taking.

The results are shown in Table 2.

Table 2 Test results

Significantly effective (person) effective (person) invalid (person) Example 1 38 11 1 Example 2 35 15 0 Example 3 42 8 0 Comparative example 1 twenty two 25 3 Comparative example 2 25 twenty two 3 Comparative example 3 28 19 3 Comparative example 4 17 28 5 Comparative example 5 15 28 7

Experiment 3

Take 100 ICR mice, and after 2 days of adaptive feeding, take 10 mice as the normal control group, and inject 0.2ml/mouse of S180 cell suspension (1×10 ⁷ cells/ml) subcutaneously into the rest of the mice to create immunity. low model. Afterwards, the modeled 90 mice were divided into the model group and the experimental group, and there was no significant difference in the condition of the mice among the groups. Dosing is as follows:

Experimental group 1 was administered the composition (0.1g/kg) of Example 1;

Experimental group 2 was administered the composition (0.1g/kg) of Example 2;

Experimental group 3 was administered the composition (0.1g/kg) of embodiment 3;

Experimental group 4 was given the composition (0.1g/kg) of Comparative Example 1;

Experimental group 5 was given the composition (0.1g/kg) of Comparative Example 2;

Experimental group 6 was administered the composition (0.1g/kg) of comparative example 3;

Experimental group 7 was administered the composition (0.1g/kg) of Comparative Example 4;

Experimental group 8 was given the composition (0.1g/kg) of comparative example 5;

The model group was intragastrically administered the same amount of normal saline.

One month after the administration, the effect on the proliferation function of mouse T lymphocytes was determined. The results are shown in Table 3.

Table 3 Effects on mouse T lymphocyte proliferation function

The proliferation function of T lymphocytes was evaluated by judging the stimulation index (SI). It can be seen from Table 3 that compared with the normal control group, the T lymphocyte proliferation function of the model group mice was significantly decreased; compared with the model group mice, the experimental group could significantly improve the T lymphocyte proliferation function of the mice. It shows that the composition of the present invention can improve immunity.

Each embodiment in this specification is described in a progressive manner, each embodiment focuses on the difference from other embodiments, and the same and similar parts of each embodiment can be referred to each other.

The above description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention will not be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (6)

1. A collagen peptide composition for improving immunity and anti-aging, characterized in that it comprises the following components in parts by mass: 55-70 parts of collagen peptide, 35-50 parts of whey protein, and Pluvialis red ball 20-30 parts of algae, 10-25 parts of Hericium erinaceus polysaccharide and 3-10 parts of wild jujube seed. 2. A kind of collagen peptide composition that improves immunity as claimed in claim 1, is characterized in that, comprises the component of following mass fraction: 65 parts of collagen peptides, 44 parts of whey protein, rain 28 parts of raw Haematococcus, 13 parts of Hericium erinaceus polysaccharide and 5 parts of wild jujube kernel. 3. A collagen peptide composition for improving immunity and anti-aging according to any one of claims 1 and 2, wherein the collagen peptide is tilapia skin collagen peptide. 4. A collagen peptide composition for improving immunity and anti-aging according to any one of claims 1 or 2, characterized in that the molecular weight of the collagen peptide is 1200-1500 Daltons. 5. A collagen peptide health food for improving immunity and anti-aging, characterized in that it comprises the composition according to any one of claim 1 or 2. 6. A collagen peptide health food for improving immunity and anti-aging according to claim 5, characterized in that, the health food contains more than 50% of the composition.