CN116634647A - A minimally invasive plasma treatment device and system - Google Patents

Abstract

The invention discloses a minimally invasive plasma treatment device and a minimally invasive plasma treatment system, wherein the minimally invasive plasma treatment device comprises a flexible medium pipe and an electrode, the flexible medium pipe is made of flexible insulating materials, and the pipe diameter of the flexible medium pipe is below millimeter level; the flexible medium tube comprises a hollow inner cavity, a gas input end for receiving working gas and a jet end for emitting plasma jet. The minimally invasive plasma treatment device can be used in the field of biomedical interventional therapy, wherein a flexible insulating microtubule below a millimeter level is adopted as a medium tube, is easy to bend and operate, can enter a living body to treat by utilizing atmospheric plasma jet flow, ensures the safety of entering the living body, and realizes the safety of minimally invasive interventional therapy and interventional therapy.

Description

A minimally invasive plasma treatment device and system

technical field

The invention relates to the technical field of plasma jets, in particular to a minimally invasive plasma treatment device and system.

Background technique

Atmospheric pressure-cooled plasma is an emerging research field in recent years. Atmospheric pressure-cooled plasma can be generated under atmospheric pressure, the particle temperature is close to room temperature, contains a large number of active particles, the particles are small, and the energy is concentrated. It is used in many fields such as Environmental protection, nano-manufacturing, chip etching and other fields have broad application prospects. Moreover, since the atmospheric pressure-cooled plasma is close to room temperature, it will not cause obvious thermal damage to the human body, and can effectively inactivate various bacteria, fungi, viruses and other disease microorganisms, and is widely used in the field of plasma medicine. Among them, the use of atmospheric-pressure low-temperature plasma to treat cancer has attracted widespread attention in the field of cancer therapy. However, cancer treatment usually needs to intervene in organisms, which puts forward higher requirements for plasma processing devices, and the current plasma generation devices usually cannot meet the requirements of interventional therapy, which limits its application in biomedical interventional therapy.

Contents of the invention

The present invention aims to solve at least one of the technical problems existing in the prior art. Therefore, the present invention proposes a minimally invasive plasma treatment device and system.

In a first aspect of the present invention, a minimally invasive plasma treatment device is proposed, which includes: a flexible dielectric tube and an electrode; the material of the flexible dielectric tube is selected from flexible insulating materials, and the diameter of the flexible dielectric tube is within mm Below the level; the flexible dielectric tube includes a hollow inner cavity, a gas input end for receiving working gas, and a jet end for emitting plasma jet.

According to the embodiment of the present invention, the minimally invasive plasma processing device has at least the following beneficial effects: the minimally invasive plasma processing device adopts a flexible dielectric tube and electrodes, and the flexible dielectric tube includes a hollow inner cavity, a gas input port for receiving working gas, and an exit plasma The jet end of the body jet, the flexible dielectric tube is made of flexible insulating material, and its diameter is below the millimeter level. The minimally invasive plasma treatment device can be used in the field of biomedical interventional therapy, wherein the flexible insulating microtube below the millimeter level is used as the medium tube , which is easy to bend and operate, can enter the living body and use the atmospheric plasma jet for treatment, and ensure the safety of entering the living body, so as to realize the minimally invasive interventional treatment and ensure the safety of the interventional treatment.

In some embodiments of the present invention, the electrodes are selected from any one or a combination of ring electrodes and needle electrodes;

The ring-shaped electrode is sheathed on the outer wall of the flexible dielectric tube close to the jet end, and an insulating sleeve is also sleeved on the flexible dielectric tube, and the insulating sleeve covers the ring-shaped electrode;

The needle-shaped electrode is disposed inside the hollow cavity at a position close to the jet end.

That is, in some embodiments, the electrode can be a needle-shaped electrode built in the hollow cavity close to the jet end; in some embodiments, the outer wall of the flexible medium tube near the jet end can be used alone At the same time, an insulating sleeve can be sleeved on the flexible dielectric tube, and the insulating sleeve covers the ring electrode; in some embodiments, the above needle electrode can also be used to cooperate with the ring electrode.

In some embodiments of the invention, the ring electrode is configured to generate a glow discharge plasma jet, and the needle electrode is configured to generate a glow discharge plasma jet or an arc depending on the exit distance from the jet end The discharge plasma jet can then control different discharge modes according to different electrode structures to achieve different treatment methods.

In some embodiments of the present invention, the distance between the needle-shaped electrode and the outlet of the jet end is 10-15 mm. At this distance, the needle-shaped electrodes can be configured to generate glow discharge plasma jets, which can reduce or even avoid damage to organisms caused by tip discharge.

In some embodiments of the invention, the needle electrode is less than 10 mm from the outlet of the jet end, at which distance the needle electrode can be configured to generate an arc discharge plasma jet.

In some embodiments of the present invention, the electrode adopts a ring electrode, and the flexible dielectric tube cooperates with the jacket-type ring electrode, and an insulating sleeve is further set to cover the ring electrode, which can effectively avoid the traditional plasma generation device. When the metal probe is too close to the target, it is easy to cause arc discharge and damage the tissue; the coating setting of the outer insulating sleeve of the ring electrode on the flexible dielectric tube can avoid the problem of accidental discharge easily caused by the traditional needle electrode. Realize precise plasma interventional therapy for tumors; in addition, the ring-shaped electrode covered by an insulating sleeve is set on the flexible dielectric tube, which increases the treatment area of the atmospheric pressure-cooled plasma compared with the needle-shaped electrode, making it easier to concentrate the treatment In tumor tissue, improve the free radical production rate and treatment efficiency, and avoid accidental discharge. The minimally invasive plasma treatment device can control the active substances produced according to different voltages, and realize the treatment of tumors by the atmospheric pressure-cooled plasma in the target object. It can safely enter the body to achieve the purpose of precise tumor treatment.

In some embodiments of the present invention, the insulating sleeve is a thermoplastic pipe.

In some embodiments of the present invention, the material of the flexible medium pipe is selected from silica gel, polyvinyl alcohol (PVA), polyester (PET), polyimide (PI), polyether ether ketone (PEEK), thermoplastic Any of polyurethane elastomer rubber (TPU). The polyester (PET) can be at least one of polyethylene naphthalate (PEN), polymethacrylate (PMMA), and polycarbonate (PC).

In some embodiments of the present invention, the diameter of the flexible medium pipe is 1-8 mm.

In some embodiments of the present invention, the electrodes are metal electrodes.

In some embodiments of the present invention, the material of the electrodes is selected from any one of tungsten, copper, aluminum and stainless steel.

In a second aspect of the present invention, a minimally invasive plasma treatment system is proposed, comprising:

Any minimally invasive plasma treatment device proposed in the first aspect of the present invention;

A power supply electrically connected to the electrodes in the minimally invasive plasma treatment device;

A working gas source is connected to the gas input end in the minimally invasive plasma processing device.

In some embodiments of the present invention, the minimally invasive plasma treatment system further includes a step-up transformer connected between the power supply and the electrodes.

In some embodiments of the present invention, the working gas source is connected to the gas input end of the minimally invasive plasma processing device through a pipeline, and a gas valve and a gas flow meter are arranged on the pipeline, and the gas The flow meter is arranged between the gas valve and the gas input end.

Description of drawings

The present invention will be further described below in conjunction with accompanying drawing and embodiment, wherein:

FIG. 1 is a schematic structural view of an embodiment of a minimally invasive plasma treatment device of the present invention;

2 is a schematic structural view of an embodiment of the minimally invasive plasma processing system of the present invention;

Fig. 3 is a workflow diagram of the minimally invasive plasma treatment system shown in Fig. 2 applied to a living body;

Fig. 4 is a voltage waveform diagram generated by applying different DC voltages to the power supply in the minimally invasive plasma processing system shown in Fig. 2 and passing through the step-up transformer;

Fig. 5 is an optical generation and emission spectrum diagram of the atmospheric pressure He plasma jet generated by the minimally invasive plasma processing device driven by the minimally invasive plasma processing system shown in Fig. 2 under the drive of 6V input voltage;

Fig. 6 is an optical generation and emission spectrum diagram of the atmospheric pressure He plasma jet generated by the minimally invasive plasma processing device driven by the minimally invasive plasma processing system shown in Fig. 2 driven by an input voltage of 9V;

Fig. 7 is an optical generation and emission spectrum diagram of the atmospheric pressure He plasma jet generated by the minimally invasive plasma processing device driven by the minimally invasive plasma processing system shown in Fig. 2 under the input voltage of 12V;

Fig. 8 is a schematic structural view of another embodiment of the minimally invasive plasma treatment device of the present invention;

Fig. 9 is a schematic structural diagram of another embodiment of the minimally invasive plasma treatment device of the present invention.

Detailed ways

Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

In the description of the present invention, several means more than one, and multiple means more than two. Greater than, less than, exceeding, etc. are understood as not including the original number, and above, below, within, etc. are understood as including the original number. If the description of the first and second is only for the purpose of distinguishing the technical features, it cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features relation.

In the description of the present invention, unless otherwise clearly defined, words such as setting, installation, and connection should be understood in a broad sense, and those skilled in the art can reasonably determine the specific meanings of the above words in the present invention in combination with the specific content of the technical solution.

In the description of the present invention, reference to the terms "one embodiment," "some embodiments," "exemplary embodiments," "examples," "specific examples," or "some examples" is intended to mean that the embodiments are A specific feature, structure, material, or characteristic described by or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Please refer to FIG. 1 . FIG. 1 shows a schematic structural diagram of an embodiment of a minimally invasive plasma treatment device of the present invention. As shown in Figure 1, the minimally invasive plasma treatment device 10 includes a flexible dielectric tube 11 and electrodes, wherein the flexible dielectric tube 11 includes a hollow cavity 113, a gas input end 111 for receiving a working gas, and a jet end for emitting a plasma jet 112; in this embodiment, the electrode is a ring-shaped electrode 12, and the ring-shaped electrode 12 is sleeved on the outer wall of the flexible dielectric tube 11 close to the jet end 112; the outer wall of the flexible dielectric tube 11 is also sleeved with an insulating sleeve 13, And the insulating sleeve 13 covers the ring electrode 12 .

Wherein, the flexible medium pipe 11 is a hollow tubular structure, specifically a hollow inner cavity 113 . The material of the flexible medium tube 11 is selected from flexible insulating materials. The material needs to ensure biocompatibility and stability when entering the organism. The stability includes that after the flexible medium tube 11 enters the organism, even if it is bent, it can also ensure flexibility. The connectivity of the medium pipe 11, the material of the flexible medium pipe 11 can be silica gel, polyvinyl alcohol (PVA), polyester (PET), polyimide (PI), polyether ether ketone (PEEK), thermoplastic polyurethane elastic At least one of body rubber (TPU), polyester (PET) can use at least one of polyethylene naphthalate (PEN), polymethacrylate (PMMA), polycarbonate (PC) First, the flexible dielectric tube 11 is made of a flexible insulating material, which is easy to bend, thereby making it easier to operate, which can effectively avoid the problem that the metal microneedle of the traditional minimally invasive plasma treatment device is easy to cause damage, and ensure the safety of entering the living body. The diameter of the flexible medium tube 11 is below the millimeter level, so as to facilitate the preparation of a miniature minimally invasive plasma treatment device that can safely enter the body to treat lesions. For example, the flexible medium tube 11 can be a millimeter tube (such as a diameter of 1 to 8 mm), microtubes, nanotubes. The length of the flexible medium pipe 11 is not limited, and can be specifically designed according to actual needs.

In this embodiment, the plasma jet is generated by exciting a single electrode, specifically, a ring-shaped single electrode, that is, the ring-shaped electrode 12 . The ring electrode 12 may be configured to generate a glow discharge plasma jet. The ring electrode 12 can be a metal electrode, and its material can be tungsten, copper, aluminum, stainless steel and the like. The ring-shaped metal electrode is sleeved on the outer wall of the flexible insulating dielectric tube, and plasma can be generated by the principle of dielectric barrier discharge during operation. The use of the ring electrode 12 can effectively increase the plasma production area, making it easier to concentrate the treatment on the tumor tissue, and improve the free radical production rate and treatment efficiency. In addition, the annular electrode 12 can specifically adopt an annular high-voltage electrode (that is, an annular high-voltage single electrode). The plasma excited by the annular high-voltage electrode will be more stable during the working process, avoiding the danger of high-voltage discharge. Generally, the distance between the ring electrode 12 and the nozzle of the jet end of the flexible dielectric tube 11 is controlled to be 5-15 mm.

The insulating sleeve 13 is a thermoplastic tube, which is used to wrap the ring electrode 12. Specifically, it can wrap the ring electrode 12 to play the role of insulation and protection, so as to avoid accidental discharge and realize precise plasma interventional treatment of tumors. Moreover, the ring electrode 12 can generally be led out through a wire 14 to facilitate connection with a power source.

Please refer to FIG. 2 . FIG. 2 shows a schematic structural diagram of an embodiment of the minimally invasive plasma processing system of the present invention. As shown in FIG. 2 , the minimally invasive plasma processing system includes a minimally invasive plasma processing device 10 , a power source 20 and a working gas source 30 . Wherein, the structure of the minimally invasive plasma processing device 10 is shown in Figure 1, and will not be repeated here; the power supply 20 is electrically connected to the annular electrode 12 in the minimally invasive plasma processing device 10; the working gas source 30 is connected to the minimally invasive plasma processing device 10; The gas input terminal 111 in the plasma processing apparatus 10 is connected.

In this embodiment, the power supply 20 adopts a low-voltage direct current power supply, the electrode at the first end of the power supply 20 is connected to the ring electrode, and the electrode at the other end is grounded. In addition, the minimally invasive plasma treatment system also includes a step-up transformer 40, which is connected between the power supply 20 and the annular electrode 12 of the minimally invasive plasma treatment device 10, for converting the low-voltage direct current provided by the low-voltage direct-current power supply into high-voltage alternating current. The safety and reliability of the minimally invasive plasma processing system can be improved through the coordinated arrangement of the power supply 20 and the step-up transformer 40 above. Specifically, the voltage converted by the step-up transformer 40 is 4-6 kV, and the frequency is 16-20 kHz.

The working gas source 30 is used for the supply of working gas, specifically, a gas cylinder can be used; the working gas can be He, Ar, N ₂ , O ₂ or their mixed gases, and rare gases such as helium are generally used as the medium. In this embodiment, the working gas source 30 is connected to the gas input port 111 in the plasma jet generator 10 through a pipeline 31, and the pipeline 31 is provided with a gas valve 32 and a gas flowmeter 33, and the gas flowmeter 33 is located at Between the gas valve 32 and the gas input port 111 . Through the coordinated arrangement of the gas valve 32 and the gas flow meter 33 , the flow rate of the working gas entering the hollow cavity 113 of the flexible medium pipe 11 can be easily controlled.

When the above minimally invasive plasma processing system is working, the working gas in the working gas source 30 is delivered to the hollow inner cavity 113 of the flexible medium tube 11 through the pipeline 31 through the monitoring and control of the gas valve 32 and the gas flow meter 33; turn on the power supply 20 , the low-voltage direct current provided by the power supply 20 is converted into high-voltage alternating current by the step-up transformer 40, and transmitted to the annular electrode 12 of the minimally invasive plasma treatment device 10, and then the flexible dielectric tube 11 is covered by the annular electrode 12 covered by the insulating sleeve 13 The working gas at the corresponding position is broken down to generate a discharge, so that a uniform low-temperature plasma can be generated under atmospheric pressure in the form of a dielectric barrier discharge. The plasma treatment device adopts an external ring electrode, and the generated plasma jet is thicker and less likely to cause damage to the tissue.

When the above minimally invasive plasma treatment system acts on organisms, the entire working process can be divided into five stages, as shown in Figure 3, which are: when the plasma jet does not touch the organism, when the plasma jet touches the organism , continue to approach, when the flexible medium tube touches the living body, and when the minimally invasive plasma treatment device enters the living body. Among them, when the plasma jet touches the organism, the end of the jet is slender and obvious, as shown in (a) in Figure 3; while when the plasma jet touches the organism, the plasma jet is brighter, as shown in Figure 3 (b) As shown; when the plasma jet continues to approach the organism, the jet becomes shorter and brighter, as shown in (c) in Figure 3; until the flexible medium tube touches the organism as shown in (d) in Figure 3 and as shown When the minimally invasive plasma treatment device shown in (e) in Fig. 2 enters a living body, the plasma jet will diverge and cannot be observed.

In addition, the inventor used the minimally invasive plasma processing system shown in Figure 2 to conduct experiments on living organisms (mice), specifically using helium as the working gas, and setting three different DC power input voltages, 6V and 9V respectively. , 12V, after testing the above DC voltage passes through the step-up transformer to produce a stable positive selection voltage waveform, as shown in Figure 4, where (a), (b), (c) respectively represent 6V, 9V, 12V The sinusoidal waveforms generated by the DC voltage through the step-up transformer correspond to output voltages of 5.28kV, 7.92kV and 9.84kV respectively.

Then test the optical emission spectrum (ie OES) of the atmospheric pressure He plasma jet generated by the minimally invasive plasma processing device driven by the above three different input voltages (6V, 9V, 12V), the measurement range is 315nm to 800nm, The OES of five working stages at the same position was measured under each set of voltages, namely, when the plasma jet does not touch the organism, when the plasma jet touches the organism, continues to approach, when the flexible dielectric tube touches the organism, and minimally invasive plasma When the body treatment device enters the organism, the results obtained are shown in Figures 5 to 7, where (a) to (e) respectively represent when the plasma jet does not touch the organism, when the plasma jet touches the organism, continues to approach, and flexibly The optical generation emission spectrum of the normal-pressure He plasma jet generated by the minimally invasive plasma processing device when the dielectric tube contacts the living body and when the minimally invasive plasma processing device enters the living body. The peaks in Figures 5-7 indicate the presence of key chemical elements reactive nitrogen (RNS) and reactive oxygen species (ROS) in the plasma jet. Specifically, it can be seen from (a) in Figures 5 to 7 that there are N ₂ , N ₂ ⁺ , He and O species in the plasma jet in the initial state (when the plasma jet does not touch the organism); compared to (a ) the data of the state shown in the figure, (b) shows that when the plasma jet touches the organism, the data increases; and as the plasma jet continues to approach the organism, the OES result does not change significantly; but when the flexible dielectric tube When in contact with organisms, the outlet of the jet end of the flexible medium tube abuts the contact surface, which is equivalent to the contact surface closing the jet end outlet of the flexible medium tube. Except for the peak value of He, the values of other species are significantly reduced, even It cannot be measured; and when the minimally invasive plasma treatment device has completely entered the organism, because the organism conducts electricity, the ring electrode is in contact with the organism through the insulating sleeve. As the material increases, the value will rise and remain at a stable stage. The change in the effect of the above minimally invasive plasma generating device applied to a living body can reflect laterally the safety of the device acting on a living body. In addition, by comparing the test results shown in Figure 5, Figure 6 and Figure 7, it can be seen that as the input voltage gradually increases from 6V to 12V, the peak value at the same stage increases with the increase of voltage, and the peak value of OES shown in Figure 7 Highest.

Therefore, the above minimally invasive plasma treatment device uses a flexible dielectric tube, which is easy to bend and easier to operate, and can ensure the safety of entering the living body; it cooperates with the jacket-type annular electrode, and is further sleeved with an insulating sleeve to cover The ring electrode can effectively avoid arc discharge and damage to the tissue when the metal probe is too close to the target in the traditional minimally invasive plasma processing device; the coating setting of the outer insulating sleeve of the ring electrode on the flexible dielectric tube can avoid The traditional needle-shaped electrode is prone to accidental discharge, which can realize precise plasma interventional therapy for tumors; moreover, the ring-shaped electrode covered with an insulating sleeve is set on the flexible dielectric tube, which increases the efficiency compared with the use of needle-shaped electrodes. Larger atmospheric pressure cooling plasma treatment area makes it easier to focus on tumor tissue, improves free radical production rate and treatment efficiency, and avoids accidental discharge. The device is easy to use and easy to operate, and can control the active substances produced according to different voltages to realize the treatment of tumors with atmospheric pressure-cooled plasma in the target object. The body can safely enter the body to achieve the purpose of precise tumor treatment.

In addition, please refer to FIG. 8 , which shows a schematic structural diagram of another embodiment of the minimally invasive plasma treatment device of the present invention. As shown in Fig. 8, the minimally invasive plasma treatment device includes a flexible dielectric tube 11a and electrodes. Wherein, the flexible dielectric tube 11 a is basically the same as the flexible dielectric tube 11 in the minimally invasive plasma processing device shown in FIG. 1 , and details will not be repeated here.

In this embodiment, the electrode is a needle-shaped electrode 12a, which is installed in the hollow cavity of the flexible medium tube 11a at a position close to the jet end. The needle electrode 12a can be configured to generate a glow discharge plasma jet or an solitary discharge plasma jet according to the distance from the outlet of the flexible dielectric tube 11a, so that different discharge modes can be controlled to achieve different treatment methods.

Specifically, in some embodiments, the needle-shaped electrode 12a can be controlled to be 10-15cm away from the outlet of the jet end of the flexible dielectric tube 11a. At this distance, the needle-shaped electrode can be configured to generate glow discharge plasma jets, which can reduce or even Avoid the damage of the tip to the organism, and improve the safety of its application in interventional therapy. In some other embodiments, the distance between the needle electrode 12a and the jet end of the flexible dielectric tube 11a can also be controlled to be less than 10mm. At this distance, the needle electrode 12a can be configured to generate arc discharge plasma jets; under high voltage working conditions Under the condition, the needle-shaped electrode 12a in the tube may emit sharp discharge, which is harmful to the living body, but it can be used for cutting, surgery, burning, etc. in the medical field. For example, ophthalmologists and dermatologists can use solitary light discharge for surgical cutting and cutting Open, as well as the treatment of squamous cell carcinoma, removal of moles, etc. Thus, according to the needs of treatment, the installation position of the electrodes can be adjusted, so as to control different discharge modes and realize different treatment methods.

The above minimally invasive plasma processing device can be similar to that shown in Figure 2, and cooperate with the power supply and working gas source to construct a micro plasma system, wherein one end electrode of the power supply is electrically connected to the needle-shaped electrode 12a in the minimally invasive plasma processing device , the electrode at the other end is grounded, and the working gas source is connected to the gas input end in the minimally invasive plasma processing device.

Furthermore, please refer to FIG. 9 , which shows a schematic structural diagram of another embodiment of the minimally invasive plasma treatment device of the present invention. As shown in Fig. 9, the minimally invasive plasma treatment device includes a flexible dielectric tube 11b and an electrode 12b. Wherein, the flexible dielectric tube 11b is basically the same as the flexible dielectric tube 11 in the minimally invasive plasma processing device shown in FIG. 1 , and details will not be repeated here.

In this embodiment, the electrode 12b is composed of a ring electrode and a needle electrode. Wherein, the ring electrode is basically the same in structure and arrangement as the ring electrode 12 in the minimally invasive plasma treatment device shown in FIG. The outer wall is also covered with an insulating sleeve, and the insulating sleeve covers the ring-shaped electrode; the structure and arrangement of the needle-shaped electrode are basically the same as those in the minimally invasive plasma processing device shown in Figure 8. The position in the hollow cavity of the flexible medium tube 11b is close to the jet end.

The electrode in the minimally invasive plasma treatment device adopts a double-electrode structure, which is easier to excite a stable plasma jet, and different structures can control different discharge modes, which are applicable and meet different treatment needs. In a specific application, the minimally invasive plasma processing device can cooperate with the power supply and the working gas source to construct a micro plasma system as shown in Figure 2, wherein, one end electrode of the power supply is connected to the needle-shaped electrode in the minimally invasive plasma processing device. The electrodes are electrically connected, the other end is electrically connected to the ring electrode, and the working gas source is connected to the gas input end of the minimally invasive plasma processing device.

The above minimally invasive plasma treatment devices can be used in the field of biomedical interventional therapy. Among them, flexible insulating microtubes below the millimeter level are used as medium tubes, which are easy to bend and operate, and can enter living organisms for treatment with atmospheric plasma jets. Ensure the safety of entering the living body, realize the use of minimally invasive interventional therapy and ensure the safety of interventional therapy.

The above-mentioned embodiments only express several implementation modes of the present invention, and the description thereof is relatively specific and detailed, but should not be construed as limiting the patent scope of the present invention. It should be noted that, for those skilled in the art, several modifications and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention.

Claims (10)

1. A minimally invasive plasma processing device, which is characterized by comprising a flexible medium tube and an electrode; the flexible medium pipe is made of flexible insulating materials, and the pipe diameter of the flexible medium pipe is below millimeter level; the flexible medium tube comprises a hollow inner cavity, a gas input end for receiving working gas and a jet end for emitting plasma jet.

2. The minimally invasive plasma processing apparatus according to claim 1, wherein the electrode is selected from one or a combination of two of a ring-shaped electrode and a needle-shaped electrode;

the annular electrode is sleeved on the outer wall of the flexible medium pipe, which is close to the jet end, and the flexible medium pipe is also sleeved with an insulating sleeve, and the insulating sleeve covers the annular electrode;

the needle electrode is arranged in the hollow inner cavity at a position close to the jet end.

3. The minimally invasive plasma processing apparatus according to claim 2, wherein the ring electrode is configured to generate a glow discharge plasma jet; the needle electrode is configured to generate a glow discharge plasma jet or an islanding discharge plasma jet according to an exit distance from the jet end.

4. The minimally invasive plasma treatment device according to claim 2, wherein the needle electrode is 10-15 mm from the outlet of the jet end.

5. The minimally invasive plasma treatment device of claim 2, wherein the insulating sleeve is a thermoplastic tube.

6. The minimally invasive plasma processing apparatus according to claim 1, wherein the flexible dielectric tube is made of at least one material selected from the group consisting of silicone rubber, polyvinyl alcohol, polyester, polyimide, polyetheretherketone, and thermoplastic polyurethane elastomer rubber.

7. The minimally invasive plasma processing apparatus according to claim 1, wherein the electrode is a metal electrode; preferably, the electrode is made of any one of tungsten, copper, aluminum and stainless steel.

8. A minimally invasive plasma processing system, comprising:

the minimally invasive plasma processing apparatus of any of claims 1 to 7;

the power supply is electrically connected with the electrode in the minimally invasive plasma treatment device;

and the working gas source is connected with a gas input end in the minimally invasive plasma processing device.

9. The minimally invasive plasma processing system according to claim 8, further comprising a step-up transformer connected between the power source and the electrode.

10. The minimally invasive plasma processing system according to claim 8, wherein the working gas source is connected to a gas input in the minimally invasive plasma processing apparatus through a pipeline, a gas valve and a gas flow meter are provided on the pipeline, and the gas flow meter is provided between the gas valve and the gas input.