CN116616756A - A continuous blood glucose monitoring system and its control method - Google Patents

Abstract

The present application provides a continuous blood glucose monitoring system and its control method, which relate to the field of test control. The method includes: after the continuous blood glucose monitoring system is awakened, immediately obtain multiple current values generated by the sensor within a predetermined period at a predetermined frequency; Whether the initial current value generated by the sensor is zero, and if so, then: remove the initial current value from multiple current values to obtain the current value sequence, and judge whether the current values in the current value sequence increase sequentially, and the current in the current value sequence Whether the absolute value of the slope of the value is not less than the preset number of absolute values of the slope is not less than the preset number, and if so: control the continuous blood glucose monitoring system to start blood glucose monitoring. This application can avoid the inconsistency of the start time of the continuous blood glucose monitoring system caused by manual operation, so as to ensure the accuracy of the measurement value of the continuous blood glucose monitoring system, and at the same time, prevent the implanted sensor from being repeated without being removed from the body. use.

Description

A continuous blood glucose monitoring system and its control method

technical field

The present application relates to the field of test control, in particular to a dynamic blood glucose monitoring system and a control method thereof.

Background technique

After the implantable sensor in the continuous glucose monitoring system (Continuous Glucose Monitoring System, CGMS) is implanted in the body, it needs to be connected to the transmitter through an external Bluetooth device, and the continuous glucose monitoring system will start testing through manual operation. Not convenient enough to use, not smart enough. And the manual operation will cause the implantable sensor to be implanted in the body, and the start time of the test will be inconsistent (for example, it will start immediately after implantation, and it will start after a few minutes or hours after implantation, and the difference in start time will affect Algorithm), thus affecting the measurement accuracy of the continuous blood glucose monitoring system.

In addition, after the continuous blood glucose monitoring system automatically ends the monitoring after the expiration date is reached, the user may reset the transmitter by unconventional means without removing the used sensor from the body, thereby reusing the sensor, resulting in inaccurate test values Or the test is abnormal, causing the user to take wrong remedial measures, such as the wrong timing or dosage of medication, which may even affect the life of the user in serious cases.

Therefore, how to avoid the inconsistency of the start time of the continuous blood glucose monitoring system caused by manual operation, so as to ensure the accuracy of the measurement value of the continuous blood glucose monitoring system, and at the same time, prevent the implanted sensor from being repeated without being removed from the body Use is a technical problem to be solved urgently by those skilled in the art.

Contents of the invention

In order to solve the above-mentioned technical problems, the present application provides a control method of a continuous blood glucose monitoring system, which can avoid the inconsistency of the test start time of the continuous blood glucose monitoring system caused by manual operation, thereby ensuring the accuracy of the measurement value of the continuous blood glucose monitoring system, At the same time, the implanted sensor is prevented from being reused without being removed from the body. The present application also provides a continuous blood glucose monitoring system, which has the same technical effect.

The first object of the present application is to provide a control method for a continuous blood glucose monitoring system.

The above-mentioned application purpose one of the present application is achieved through the following technical solutions:

A control method for a continuous blood glucose monitoring system, comprising:

After the continuous blood glucose monitoring system is woken up, it immediately obtains multiple current values generated by the sensor within a predetermined period at a predetermined frequency;

Judging whether the initial current value generated by the sensor is zero, if so, then: removing the initial current value from a plurality of the current values to obtain a current value sequence, and judging whether the current values in the current value sequence are sequentially Incremental, and whether the absolute value of the slope of the current value in the current value sequence is not less than the preset slope absolute value is not less than the preset number, if so:

Controlling the continuous blood glucose monitoring system to start blood glucose monitoring.

Preferably, in the control method of the continuous blood glucose monitoring system, when it is determined that the current values in the current value sequence increase sequentially, and the absolute value of the slope of the current value in the current value sequence is not less than the preset absolute value of the slope After the quantity is not less than the preset quantity, it also includes:

It is judged whether the slope values of a plurality of consecutive current values in the current value sequence are not equal, and if so, the continuous blood glucose monitoring system is controlled to start blood glucose monitoring.

Preferably, in the control method of the continuous blood glucose monitoring system, after it is determined that the slope values of a plurality of consecutive current values in the current value sequence are not equal, it further includes:

Judging whether the proportion of current values in the current value sequence in the preset current value interval including the endpoint is not lower than the preset proportion, and if so, controlling the continuous blood glucose monitoring system to start blood glucose monitoring.

Preferably, in the control method of the continuous blood glucose monitoring system, when it is judged that the current value in the current value sequence is within the preset current value interval including the endpoint, the ratio of the number of current values is not lower than the preset ratio, Also includes:

Acquiring the first difference number of current value differences between adjacent current values in the current value sequence that is not less than the preset difference lower limit, and the current value difference between adjacent current values in the current value sequence is not greater than The second difference quantity of the preset difference upper limit;

Judging whether the first difference number is not less than a first preset threshold, and whether the second difference number is not less than a second preset threshold, and if so, controlling the continuous blood glucose monitoring system to start blood glucose monitoring.

Preferably, in the control method of the continuous blood glucose monitoring system, after the control of the continuous blood glucose monitoring system to start blood glucose monitoring, it further includes:

Judging whether the total number of glucose concentration values acquired by the continuous blood glucose monitoring system exceeds the preset total, or judging whether the total duration of the current collected by the continuous blood glucose monitoring system exceeds the preset duration, and if one of them is yes, then control the dynamic The blood glucose monitoring system stops blood glucose monitoring.

Preferably, in the control method of the continuous blood glucose monitoring system, the absolute value of the preset slope and the preset number are determined by the following steps:

Acquiring a plurality of detected current value sequences obtained by excluding the initial current value obtained by performing current detection at the predetermined frequency within the predetermined period by the plurality of sensors in the simulated detection environment;

calculating the absolute value of the slope of each current value in each of the detected current value sequences to obtain a plurality of slope absolute value sequences;

From each of the slope absolute value sequences, respectively select the minimum value among the preset number of larger values in the slope absolute value, to obtain a slope absolute value selection sequence including a plurality of the minimum values;

Using the absolute value of the slope to select the minimum value in the sequence as the absolute value of the preset slope;

Wherein, the preset number is any value among 3, 4 or 5.

Preferably, in the control method of the continuous blood glucose monitoring system, the preset current value range and the preset ratio are determined by the following steps:

Acquiring a plurality of detected current value sequences obtained by excluding the initial current value obtained by performing current detection at the predetermined frequency within the predetermined period by the plurality of sensors in the simulated detection environment;

Obtaining the minimum value in each sequence of detected current values to form a lower limit sequence including multiple minimum values of current values;

Obtaining the maximum value in each sequence of detected current values to form an upper limit sequence containing a plurality of maximum current values;

taking the minimum value in the lower limit sequence as the lower limit of the preset current value interval, and taking the maximum value in the upper limit sequence as the upper limit of the preset current value interval;

Wherein, the preset ratio is any value from 0.7 to 1.

Preferably, in the control method of the continuous blood glucose monitoring system, the preset difference lower limit and the preset difference upper limit are determined by the following steps:

Acquiring a plurality of detected current value sequences obtained by excluding the initial current value obtained by performing current detection at the predetermined frequency within the predetermined period by the plurality of sensors in the simulated detection environment;

calculating the absolute value of the difference between all adjacent current values in each sequence of detected current values to obtain a plurality of absolute value sequences of the difference;

From each sequence of absolute difference values, respectively select the first minimum value among the first preset threshold and larger values in the absolute value difference, and obtain the first minimum value containing a plurality of the first minimum values sequence;

From each of the difference absolute value sequences, respectively select the first maximum value among the second preset threshold smaller values in the difference absolute value, and obtain the second maximum value containing a plurality of the first maximum values sequence;

The minimum value in the first sequence is used as the preset difference lower limit, and the maximum value in the second sequence is used as the preset difference upper limit.

Preferably, in the control method of the continuous blood glucose monitoring system, the first preset threshold is any value among 3, 4 and 5;

The second preset threshold is the number of current values in the current value sequence minus one.

The second purpose of the present application is to provide a continuous blood glucose monitoring system.

The above-mentioned application purpose two of the present application is achieved through the following technical solutions:

A continuous blood glucose monitoring system, comprising: a sensor and a data processing unit for receiving signals collected by the sensor, and the data processing unit is used for executing instructions to implement the method described in any one of the control methods for the above continuous blood glucose monitoring system .

In the above technical solution, after the continuous blood glucose monitoring system is woken up, it immediately obtains multiple current values generated by the sensor within a predetermined period at a predetermined frequency. Among them, the sensor has not been exposed to glucose before implantation, so the initial current generated after the sensor starts to operate The value is zero. After the sensor is implanted and operated, if the sensor is not removed from the body, the initial current value of the sensor will not be zero; further, by judging whether the initial current value generated by the sensor is zero, and only when the initial current value of the sensor When the value is zero, it is possible to trigger the continuous blood glucose monitoring system to start blood glucose monitoring, thereby preventing the patient from resetting the device through unconventional means without removing the sensor, and preventing the implanted sensor from being reused. Further, the initial current value is removed from the plurality of current values to obtain the current value sequence, and by judging whether the current value in the current value sequence increases sequentially, and the absolute value of the slope of the current value in the current value sequence is not less than the preset slope absolute value Whether the number of values is not less than the preset number can determine whether the sensor is operating normally. When the conditions are met, the continuous blood glucose monitoring system will be automatically controlled to start blood glucose monitoring, so as to avoid manual operation. Time inconsistency, so as to ensure the accuracy of the measurement value of the continuous blood glucose monitoring system.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments described in this application. Those skilled in the art can also obtain other drawings based on these drawings without creative work.

FIG. 1 is a schematic flowchart of a control method of a continuous blood glucose monitoring system provided in an embodiment of the present application;

FIG. 2 is another schematic flowchart of a control method of a continuous blood glucose monitoring system provided in an embodiment of the present application;

Fig. 3 is a schematic structural diagram of a continuous blood glucose monitoring system provided in an embodiment of the present application.

Detailed ways

In order to enable those skilled in the art to better understand the technical solution in the application, the technical solution in the embodiment of the application will be clearly and completely described below, obviously, the described embodiment is only a part of the embodiment of the application , but not all examples. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of this application.

In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of these features. In the description of the present application, the meanings of "plurality" and "several" are two or more, unless otherwise specifically defined.

If a flow chart is used in the present application, the flow chart is used to illustrate the operations performed by the system according to the embodiment of the present application. It should be understood that the preceding or following operations are not necessarily performed in the exact order. Instead, various steps may be processed in reverse order or simultaneously. At the same time, other operations can be added to these procedures, or a certain step or steps can be removed from these procedures.

It should also be noted that, herein, terms such as "comprises", "comprises" or any other variation thereof are intended to cover a non-exclusive inclusion such that an article or device comprising a series of elements includes not only those elements, but also Contains other elements not expressly listed, or also includes elements inherent in the article or equipment. Without further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of additional identical elements in an article or device comprising the aforementioned element.

The continuous blood glucose monitoring system is an innovative technological breakthrough in the field of blood glucose monitoring, which reflects the blood glucose level by continuously monitoring the glucose concentration in the subcutaneous intercellular fluid. The continuous blood glucose monitoring system can accurately and automatically record the patient's blood glucose level and related events (medication, insulin, diet and exercise, etc.), and download complete single-day blood glucose diagrams, multi-day blood glucose diagrams, blood glucose diagrams before and after meals, specific Time-segment blood sugar chart and statistical data table report, from which you can understand comprehensive blood sugar information, discover many rules of high blood sugar, low blood sugar and blood sugar fluctuations that are not easy to find at ordinary times, and understand the relationship between oral medicine, insulin, diet, exercise, etc. and blood sugar It provides a valuable clinical basis for formulating and evaluating rationalized and individualized hypoglycemic treatment programs, and effectively helps diabetic patients to educate and improve patients' understanding and compliance with diabetes.

The embodiment of this application is written in a progressive manner.

As shown in Figure 1, the embodiment of the present application provides a control method for a continuous blood glucose monitoring system, including:

S101. After the continuous blood glucose monitoring system is woken up, immediately obtain multiple current values generated by the sensor within a predetermined period at a predetermined frequency;

In S101, the continuous blood glucose monitoring system may include a sensor and a transmitter. The function of the sensor is to react with the glucose in the subcutaneous tissue fluid to generate current; The generated current value data is processed to obtain the blood sugar value and then sent to the external client. Wherein, the internal circuit of the transmitter may include a device wake-up circuit, an IV conversion and voltage amplification circuit, an ADC acquisition circuit, a data processing and control circuit of a Bluetooth MCU, and a Bluetooth data transmission circuit. Specifically, the transmitter can be woken up by detecting the status of the device through the device wake-up circuit, so that the transmitter provides an excitation voltage that triggers the sensor to start running. After the transmitter is woken up, it starts to monitor the current value generated by the sensor. When glucose reacts with the sensor, A current will be generated, and the current will pass through the IV conversion and voltage amplification circuit, and then the collected voltage data will be transmitted to the Bluetooth MCU through the ADC acquisition circuit, and the Bluetooth MCU can obtain the corresponding current value after calculation. The predetermined period and predetermined frequency can be determined according to actual application requirements. For example, the predetermined period can be set to three minutes, and the predetermined frequency can be set to collect once every 10 seconds, and the present application is not limited thereto. It should be noted that the transmitter can also be designed for other types of circuits, and the sensor can use existing blood glucose sensors, such as electrochemical blood glucose sensors, etc., and dynamic blood glucose monitoring systems, and can also reasonably use other types of functional modules to collect the sensor generated The current value is not limited by this application.

S102. Determine whether the initial current value generated by the sensor is zero, if so, execute S103;

In S102, after the continuous blood glucose monitoring system is woken up, it immediately starts to obtain the current value generated by the sensor, and can also obtain the initial current value generated by the sensor. Among them, the sensor has not been exposed to glucose before implantation, so the current generated after the sensor starts to operate The initial current is zero. After the sensor is implanted and operated, if the sensor is not removed from the body, the initial current of the sensor will not be zero. In this step, by judging whether the initial current value generated by the sensor is zero, and only when the initial current value of the sensor is zero, it is possible to trigger the continuous blood glucose monitoring system to start blood glucose monitoring, thereby preventing the patient from passing through the sensor without removing the sensor. Resetting the device by unconventional means can prevent the implanted sensor from being reused, resulting in inaccurate test values or abnormal test results.

S103. Excluding the initial current value from multiple current values to obtain a current value sequence, and judging whether the current values in the current value sequence increase sequentially, and the absolute value of the slope of the current value in the current value sequence is not less than the preset absolute value of the slope Whether the quantity is not less than the preset quantity, if so, execute S104;

In S103, the initial current value is zero, which has a large gap with other obtained current values, which is not conducive to subsequent comparison and judgment. Therefore, the initial current value is firstly removed from the multiple current values to obtain a current value sequence. When the sensor is implanted and working normally, the current value will rise with a certain slope. By judging whether the current value in the current value sequence increases sequentially, it can be determined whether the current value generated by the sensor is in a rising state. By judging the current value in the current value sequence. Whether the absolute value of the slope of the value is not less than the preset number of the absolute value of the slope is not less than the preset number, can determine whether the slope of the current value meets the start-up requirements, and the calculation method of the slope of the current value can be determined according to actual application requirements , for example, it can be calculated by two points, that is, the slope calculated by the current current value and a subsequent current value is used as the slope of the current point; it can also be calculated by three points, that is, the current current value and the current value before and after it are calculated separately The average value of the two slopes obtained is used as the slope of the current current value, which can also be calculated in other ways, and the present application is not limited thereto. The slope of the current value generated during normal operation after the sensor is implanted is related to the performance of the sensor itself. Therefore, the absolute value of the preset slope and the preset number can be determined by performing batch tests on the same type of sensors in the same batch in advance. According to statistics, the absolute value of the preset slope can be consistent with the calculation method of the slope of the current value in this step during the statistical calculation process, and the absolute value of the preset slope and the preset number can also be obtained directly by other means. This application does not limited to this.

S104. Control the continuous blood glucose monitoring system to start blood glucose monitoring.

In S104, when the current value in the current value sequence increases sequentially, and the absolute value of the slope of the current value in the current value sequence is not less than the preset slope absolute value, the continuous blood glucose monitoring system is automatically controlled To start blood glucose monitoring, there is no need for personnel to manually start the detection, so as to avoid the inconsistency of the start time of the continuous blood glucose monitoring system caused by manual operation, thereby ensuring the accuracy of the measurement value of the continuous blood glucose monitoring system.

After the implantable sensor in the existing continuous blood glucose monitoring system is implanted in the body, it needs to connect the transmitter through an external bluetooth device, and the continuous blood glucose monitoring system will start testing only through manual operation. Not convenient enough to use, not smart enough. Moreover, the manual operation will cause the implantable sensor to be implanted in the body, and the time to start the test will be inconsistent, thereby affecting the accuracy of the measurement value of the continuous blood glucose monitoring system. In addition, after the continuous blood glucose monitoring system automatically ends the monitoring when the service life is reached, the user may reset the transmitter by unconventional means without removing the sensor from the body, thereby reusing the sensor, which may cause inaccurate test values or Test abnormalities lead users to take wrong remedial measures, such as the wrong timing or dosage of medication, which may even affect the safety of users in serious cases.

In the above embodiment, after the continuous blood glucose monitoring system is woken up, it immediately acquires multiple current values generated by the sensor within a predetermined period at a predetermined frequency. Among them, the sensor is not exposed to glucose before implantation, so the initial current generated after the sensor starts to operate The value is zero. After the sensor is implanted and operated, if the sensor is not removed from the body, the initial current value of the sensor will not be zero; further, by judging whether the initial current value of the sensor is zero, and only when the initial current value of the sensor When it is zero, it is possible to trigger the continuous blood glucose monitoring system to start blood glucose monitoring, thereby preventing the patient from resetting the device by unconventional means without removing the sensor, and preventing the implanted sensor from being reused. Further, the initial current value is removed from the plurality of current values to obtain the current value sequence, and by judging whether the current value in the current value sequence increases sequentially, and the absolute value of the slope of the current value in the current value sequence is not less than the preset slope absolute value Whether the number of values is not less than the preset number can determine whether the sensor is operating normally. When the conditions are met, the continuous blood glucose monitoring system will be automatically controlled to start blood glucose monitoring, so as to avoid manual operation. Time inconsistency, so as to ensure the accuracy of the measurement value of the continuous blood glucose monitoring system.

In other embodiments of the present application, the absolute value of the preset slope and the preset number can be determined by the following steps:

S201. Obtain a plurality of detection current value sequences obtained by excluding the initial current value obtained by performing current detection by multiple sensors in the simulated detection environment at a predetermined frequency within a predetermined period;

In S201, multiple sensors of the same type and batch can be extracted according to the type of sensor used in the dynamic blood glucose detection system, and under the simulated detection environment, the current test is performed based on the same predetermined period and predetermined frequency as in step S101, Obtain multiple detection current value sequences after excluding the initial current value. Among them, the number of sensors can be determined according to the actual test requirements. For example, the number of sensors can be 100, and the reliability of the test can be guaranteed by a certain amount of test data .

S202. Calculate the absolute value of the slope of each current value in each sequence of detected current values to obtain multiple absolute value sequences of slopes;

In S202, the calculation method of the slope of each current value in each detected current value sequence can be determined according to actual application requirements, for example, it can adopt the above-mentioned two-point calculation or three-point calculation method, which can be compared with step S103 The calculation method of the slope of the current value in is consistent. By calculating the slope absolute value of each current value sequence in each detection current value sequence, one slope absolute value sequence corresponding to each detection current value sequence can be obtained.

S203. From each slope absolute value sequence, respectively select the minimum value among the preset number of larger values in the slope absolute value to obtain a slope absolute value selection sequence including multiple minimum values, wherein the preset number is 3, Any value from 4 or 5.

In S203, specifically, for each slope absolute value sequence, the minimum value among a preset number of larger values in the slope absolute value may be selected, and then a slope absolute value selection sequence is formed based on all selected minimum values.

S204. Using the absolute value of the slope to select the minimum value in the sequence as the absolute value of the preset slope;

In S204, the minimum value in the selection sequence of the absolute value of the slope is used as the absolute value of the preset slope.

The absolute value of the preset slope determined by the above steps can represent that the slope of the current value generated by the sensor meets the standard of the start-up condition, and can accurately reflect the performance of the sensor; by judging that the absolute value of the slope of the current value in the current value sequence is not less than the preset Whether the number of absolute values of the slope is not less than the preset number can more accurately determine whether the sensor is operating normally, and when the condition is met, the continuous blood glucose monitoring system is automatically controlled to start blood glucose monitoring.

In a specific embodiment, 100 sensors can be randomly selected, and the dynamic blood glucose monitoring system can be used for current detection in a simulated detection environment. After the dynamic blood glucose monitoring system is woken up, the current value generated by a sensor can be collected every 10 seconds, and all the current values can be recorded. The current value of the sensor in the first three minutes is obtained by excluding the initial current value of 100 detected current value sequences.

Suppose the detection current value sequence of a certain sensor A among 100 sensors is as follows: 22.6, 26.4, 28.5, 34.2, 42.3, 50.8, 58.6, 69.7, 85.2, 97.3, 82.4, 70.2, 63.4, 55.3, 49.5, 44.9, 40.8 , 36.3, the unit is nA, take 10 seconds as a unit length of abscissa, 10nA as a unit length of ordinate, every line connecting two adjacent current values has a slope, then the formula for calculating the absolute value of the slope is as follows:

|Slope|=|(Y2-Y1)|/10

In the formula, Y2 represents the later current value among the two adjacent current values, and Y1 represents the previous current value among the two adjacent current values.

Then the absolute value sequence of the slope of the adjacent current value of sensor A (taking one decimal place) is: 0.4, 0.2, 0.6, 0.8, 0.9, 0.8, 1.1, 1.6, 1.2, 1.5, 1.2, 0.7, 0.8, 0.6, 0.5 , 0.4, 0.5.

For the absolute value sequence of the slope of sensor A, when the preset number is 3, select the minimum value 1.2 among the three larger values (ie: 1.6, 1.5, 1.2) in the absolute value of the slope, that is to say, the sensor A has at least three adjacent current values whose slopes have an absolute value ≥ 1.2.

According to the above process, a total of 100 minimum values corresponding to the requirements are obtained, and a slope absolute value selection sequence including 100 minimum values is formed.

Finally, take the absolute value of the slope and select the minimum value in the sequence as the absolute value of the preset slope value of this batch of sensors. It should be noted that the above specific embodiments are only examples, and the currents of different sensor schemes are different. The absolute value of the preset slope value needs to be set according to the corresponding sensor scheme. The absolute value of the preset slope value can also use other reasonable methods obtained, the application is not limited thereto.

In other embodiments of the present application, when it is determined that the current values in the current value sequence are increasing sequentially, and the absolute value of the slope of the current value in the current value sequence is not less than the preset number of slope absolute values is not less than the preset number ,Also includes:

S301. Determine whether the slope values of consecutive current values in the current value sequence are not equal, and if so, perform the step of controlling the continuous blood glucose monitoring system to start blood glucose monitoring.

In S301 , under normal circumstances, the current value collected by the sensor should fluctuate to a certain extent, and accordingly, the slope value of the current value in the current value sequence will also vary to a certain extent. In this step, the calculation method of the slope of the current value can refer to the above S103, and the fluctuation state of the slope is evaluated by judging whether the slope values of a plurality of consecutive current values in the current value sequence are not equal. A plurality of continuous current values can be set according to actual needs, for example, it can be 3, 5 or other numbers in a row, which is not limited in this application. In this step, when it is judged that the slope values of consecutive multiple adjacent current values in the current value sequence are equal, it can be determined that there is no change in the slope, that is, the change in the slope value of the current value does not meet the start-up requirements. When it is judged that the current When the slope values of multiple consecutive current values in the value sequence are not equal, it can be determined that there is a certain fluctuation in the slope, that is, the change in the slope value of the current value meets the start-up requirements, and then triggers the dynamic blood glucose monitoring system to start blood glucose monitoring. Based on the above judgment process, By adding the judging condition of slope fluctuation, it is possible to more accurately evaluate whether the sensor is in a normal working state.

In other embodiments of the present application, after it is determined that the slope values of the consecutive current values in the current value sequence are not equal, the method further includes:

S401. Judging whether the current value in the current value sequence is within the preset current value interval including the endpoint, and whether the proportion of the current value is not lower than the preset proportion, and if so, execute the step of controlling the dynamic blood glucose monitoring system to start blood glucose monitoring .

In S401, the preset current range and the preset ratio can be set according to actual application requirements, for example, they can be obtained statistically based on the sensor type in a batch test. The preset current value interval is used as the upper and lower limit standards of the start-up threshold of the current value generated by the sensor, and is used to verify whether the sensor is in a normal working state. Based on the above judgment process, by setting the current value in the current value sequence to the preset value containing the endpoint The judging condition of whether the quantity ratio of the current value in the current value interval is not lower than the preset ratio can more accurately evaluate whether the sensor is in a normal working state.

In other embodiments of the present application, the preset current range can be determined by the following steps:

S501. Obtain a plurality of detection current value sequences obtained by excluding the initial current value obtained by performing current detection by multiple sensors in the simulated detection environment at a predetermined frequency within a predetermined period;

In S501, for its specific implementation details, reference may be made to the above S201.

S502. Obtain the minimum value in each sequence of detected current values to form a lower limit sequence including multiple minimum values of current values;

S503. Obtain the maximum value in each detected current value sequence to form an upper limit sequence including multiple current value maximum values;

In S502 and S503, specifically, according to the minimum value and maximum value in each detected current value sequence, a lower limit sequence including all current value minimums and an upper limit sequence including all current value maximum values may be respectively constructed. It should be noted that the execution order of S502 and S503 may be interchanged, or may be executed at the same time, which does not affect the implementation of this embodiment.

S504. The minimum value in the lower limit sequence is used as the lower limit of the preset current value interval, and the maximum value in the upper limit sequence is used as the upper limit of the preset current value interval;

In S504, the minimum value in the lower limit sequence is used to characterize the lower limit standard of the start threshold of the current value generated by this type of sensor; the maximum value in the upper limit sequence is used to characterize the start threshold of the current value generated by this type of sensor upper limit standard.

The preset current value interval determined through the above steps can represent that the current value generated by the sensor meets the upper and lower limit standards of the start-up condition, and can accurately reflect the performance of the sensor. By judging that the current value in the current value sequence is within the preset current value including the endpoint Whether the proportion of the current value in the interval is not lower than the preset proportion can more accurately determine whether the sensor is operating normally. When the conditions are met, the dynamic blood glucose monitoring system is automatically controlled to start blood glucose monitoring.

In some embodiments, the preset ratio is any value from 0.7 to 1, that is, when the current value in the current value sequence not lower than the preset ratio is within the preset current value range, it is considered that the current sensor is working normally , and then automatically control the continuous blood glucose monitoring system to start blood glucose monitoring.

In a specific embodiment, 100 sensors can be randomly selected, and the dynamic blood glucose monitoring system can be used for current detection in a simulated detection environment. After the dynamic blood glucose monitoring system is woken up, the current value generated by a sensor can be collected every 10 seconds, and all the current values can be recorded. The current value of the sensor in the first three minutes is obtained by excluding the initial current value of 100 detected current value sequences.

Suppose the detection current value sequence of a certain sensor A among 100 sensors is as follows: 22.6, 26.4, 28.5, 34.2, 42.3, 50.8, 58.6, 69.7, 85.2, 97.3, 82.4, 70.2, 63.4, 55.3, 49.5, 44.9, 40.8 , 36.3, the unit is nA.

It can be seen from the above that the minimum current value of the detection current value sequence of sensor A is 22.6nA, and the maximum current value is 97.3nA. Similarly, according to the detection current value sequence of 99 sensors in the same batch as sensor A, a total of 100 can be obtained. The maximum current value and the minimum current value of the detected current value sequence form a lower limit sequence containing 100 minimum current values and an upper limit sequence containing 100 maximum current values.

Finally, take the minimum value of the lower limit sequence as the lower limit of the preset current value interval of this batch of sensors, and take the maximum value of the upper limit sequence as the upper limit of the preset current value interval of this batch of sensors, thereby obtaining the preset current value interval. It should be noted that the currents of different sensor schemes are different, and the preset current value interval needs to be set according to the corresponding sensor scheme. The preset current value interval can also be obtained by other reasonable methods, and the application is not limited thereto.

In other embodiments of the present application, after it is determined that the current value in the current value sequence is within the preset current value interval including the endpoint, the ratio of the number of current values is not lower than the preset ratio, further comprising:

S601. Obtain the first difference number of the current value difference between adjacent current values in the current value sequence that is not less than the preset difference lower limit, and the current value difference between adjacent current values in the current value sequence is not greater than the preset value The second difference amount of the upper limit of the difference;

In S601, the lower limit of the preset difference and the upper limit of the preset difference can be set according to actual application requirements. For example, they can be obtained statistically based on the batch test of the sensor type, which is used as the difference between adjacent current values generated by the sensor Satisfy the upper and lower limit criteria of the start-up condition, which is used to verify whether the sensor is in normal working condition. In some embodiments, in order to facilitate numerical comparison, the difference between adjacent current values can be taken as an absolute value, and then compared with a preset lower limit or upper limit of the difference, which does not affect the implementation of this embodiment.

S602. Determine whether the first difference number is not less than the first preset threshold, and whether the second difference number is not less than the second preset threshold, and if so, execute the step of controlling the continuous blood glucose monitoring system to start blood glucose monitoring .

In S602, the first preset threshold and the second preset threshold can be set according to actual application requirements. Based on the above judgment process, by setting whether the first difference number is not less than the first preset threshold, and the second The judging condition of whether the number of differences is not less than the second preset threshold can more accurately evaluate whether the sensor is in a normal working state.

In other embodiments of the present application, the preset difference lower limit and the preset difference upper limit are determined by the following steps:

S701. Obtain a plurality of detected current value sequences obtained by excluding the initial current value obtained by performing current detection by a plurality of sensors in the simulated detection environment at a predetermined frequency within a predetermined period;

In S701, for its specific implementation details, reference may be made to the above S201.

S702. Calculate the absolute value of the difference between all adjacent current values in each detected current value sequence, and obtain multiple absolute value sequences of the difference;

In S702, by calculating the absolute difference values of all adjacent current values in each detected current value sequence, one sequence of absolute difference values corresponding to each detected current value sequence can be obtained.

S703. From each difference absolute value sequence, respectively select the first minimum value among the first preset threshold and larger values in the difference absolute value, and obtain a first sequence including multiple first minimum values;

In S703, specifically, for each difference absolute value sequence, the first minimum value among the first preset threshold and larger values in the difference absolute value can be selected, and then according to all selected first minimum values, a The first sequence, the first sequence is used for the selection of the subsequent preset difference lower limit.

S704. From each absolute difference sequence, respectively select the first maximum value among the second preset threshold smaller values in the absolute difference value, and obtain a second sequence containing multiple first maximum values;

In S704, specifically, for each difference absolute value sequence, the first maximum value among the second preset threshold smaller values in the difference value absolute value can be selected, and then according to all selected first maximum values, a The second sequence, the second sequence is used for the selection of the subsequent preset difference upper limit.

It should be noted that the execution order of S703 and S704 may be interchanged, or may be executed at the same time, which does not affect the implementation of this embodiment.

S705. Use the minimum value in the first sequence as the preset difference lower limit, and use the maximum value in the second sequence as the preset difference upper limit.

In S705, the minimum value in the first sequence is used as the lower limit of the preset difference, and the maximum value in the second sequence is used as the upper limit of the preset difference. The minimum value in the first sequence can be understood as the value generated by each sensor The difference between adjacent current values meets the lower limit standard of the start-up condition, and the maximum value in the second sequence can be understood as the difference between adjacent current values generated by each sensor meets the upper limit standard of the start-up condition.

The lower limit of the preset difference and the upper limit of the preset difference determined by the above steps can represent that the difference between adjacent current values generated by the sensor meets the upper and lower limit standards of the start-up condition, and can accurately reflect the performance of the sensor. By judging the number of the first difference Whether it is not less than the first preset threshold and whether the second difference is not less than the second preset threshold can more accurately determine whether the sensor is operating normally. When the conditions are met, the continuous blood glucose monitoring system is automatically controlled to start the blood glucose monitor.

In some embodiments, the first preset threshold is any value among 3, 4, and 5; the second preset threshold is the number of current values in the current value sequence minus 1. Correspondingly, it can be understood that in the above S704 In , from each sequence of absolute values of differences, respectively select the maximum value in the absolute value of differences, and obtain the second sequence containing all the maximum values.

In a specific embodiment, 100 sensors can be randomly selected, and the dynamic blood glucose monitoring system can be used for current detection in a simulated detection environment. After the dynamic blood glucose monitoring system is woken up, the current value generated by a sensor can be collected every 10 seconds, and all the current values can be recorded. The current value of the sensor in the first three minutes is obtained by excluding the initial current value of 100 detected current value sequences.

Suppose the detection current value sequence of a certain sensor A among 100 sensors is as follows: 22.6, 26.4, 28.5, 34.2, 42.3, 50.8, 58.6, 69.7, 85.2, 97.3, 82.4, 70.2, 63.4, 55.3, 49.5, 44.9, 40.8 , 36.3, the unit is nA.

The absolute value of the difference between two adjacent current values=|Y2-Y1|, where Y2 represents the current value after the two adjacent current values, and Y1 represents the previous current among the two adjacent current values value.

Correspondingly, the calculated absolute value sequence of the difference of sensor A is 3.8, 2.1, 5.7, 8.1, 8.5, 7.8, 11.1, 15.5, 12.1, 14.9, 12.2, 6.8, 8.1, 5.8, 4.6, 4.1, 4.5.

For the difference absolute value sequence of sensor A, when the first preset threshold value is 3, select the first minimum value 12.2 among the three larger values (ie: 15.5, 14.9, 12.2) in the difference absolute value, That is to say, sensor A has the difference absolute value of at least three adjacent current values ≥ 12.2; in the case that the second preset threshold value is 17, select 17 smaller values in the difference absolute value (ie: 15.5, 15.5, that is, all adjacent The absolute value of the difference of the current value is ≦15.5.

According to the above process, a total of 100 sensors corresponding to the first minimum value and first maximum value meeting the requirements are obtained, respectively forming a first sequence containing 100 first minimum values and a second sequence containing 100 first maximum values.

Finally, the minimum value of the first sequence is taken as the preset difference lower limit of this batch of sensors, and the maximum value of the second sequence is taken as the preset difference upper limit of this batch of sensors. It should be noted that the above specific embodiments are only examples, and the currents of different sensor schemes are different. The lower limit of the preset difference and the upper limit of the preset difference need to be set according to the corresponding sensor scheme. The upper limit of the difference may also be obtained by using other reasonable methods, and the present application is not limited thereto.

As shown in Figure 2, in another embodiment of the present application, another method for controlling a continuous blood glucose monitoring system is provided, including:

S801. After the continuous blood glucose monitoring system is woken up, immediately obtain multiple current values generated by the sensor within a predetermined period at a predetermined frequency;

S802. Determine whether the initial current value generated by the sensor is zero, if so, execute S803;

S803. Remove the initial current value from multiple current values to obtain a current value sequence, and determine whether the current values in the current value sequence increase sequentially, and the absolute value of the slope of the current value in the current value sequence is not less than the preset absolute value of the slope Whether the quantity is not less than the preset quantity, if so, execute S804;

Wherein, for specific implementation details of S801 to S803, reference may be made to the above S101 to S103.

S804. Determine whether the slope values of consecutive current values in the current value sequence are not equal, and if so, execute S805;

Wherein, for specific implementation details of S804, reference may be made to the foregoing S301.

S805. Determine whether the current value in the current value sequence is within the preset current value interval including the endpoint, and whether the proportion of the number of current values is not lower than the preset proportion, and if so, execute S806;

Wherein, for specific implementation details of S805, reference may be made to the above S401.

S806. Obtain the first difference number of the current value difference between adjacent current values in the current value sequence that is not less than the preset difference lower limit, and the current value difference between adjacent current values in the current value sequence is not greater than the preset value The second difference amount of the upper limit of the difference;

S807. Determine whether the first difference number is not less than the first preset threshold, and whether the second difference number is not less than the second preset threshold, and if so, execute S808;

Wherein, for specific implementation details of S806 to S807, reference may be made to the above S601 to S602.

S808. Control the continuous blood glucose monitoring system to start blood glucose monitoring;

Wherein, for specific implementation details of S808, reference may be made to the above S104.

S809. Determine whether the total number of glucose concentration values acquired by the continuous blood glucose monitoring system exceeds the preset total, or determine whether the total duration of current collection by the continuous blood glucose monitoring system exceeds the preset duration, and if one of them is yes, execute S810;

In S809, after the continuous blood glucose monitoring system starts blood glucose monitoring, by judging whether the total number of glucose concentration values acquired by the continuous blood glucose monitoring system exceeds the preset total, or judging whether the total duration of current collection by the continuous blood glucose monitoring system exceeds the preset duration, Determine if the continuous glucose monitoring system has reached the end of life. The total number of presets and the preset duration can be determined according to actual application requirements. For example, the total number of presets can be 7200. When the total number of glucose concentration values is greater than 7200, the continuous blood glucose monitoring system has reached the service life.

S810. Control the continuous blood glucose monitoring system to stop the blood glucose monitoring.

In S810, when one of the judgment conditions in S809 is met, that is, when the continuous blood glucose monitoring system reaches the service life, the continuous blood glucose monitoring system is automatically controlled to stop the blood glucose monitoring without manual operation by personnel.

In this embodiment, by judging whether the initial current value generated by the sensor is zero, it is possible to prevent the user from resetting the device by unconventional means and then performing a second start test after the service life has expired without removing the sensor. , based on the judgment process from S802 to S807 above, it is possible to more accurately evaluate whether the sensor is in a normal working state; when the preset judgment conditions are met, the continuous blood glucose monitoring system can be automatically controlled to start blood glucose monitoring, so as to avoid manual operation. The time when the continuous blood glucose monitoring system starts to test is inconsistent, so as to ensure the accuracy of the measurement value of the continuous blood glucose monitoring system. By judging whether the continuous blood glucose monitoring system has reached the use period, when the use period is reached, the blood glucose monitoring can be automatically stopped without manual operation by personnel.

As shown in Figure 3, in another embodiment of the present application, a continuous blood glucose monitoring system 10 is also provided, including: a sensor 11 and a data processing unit 12 for receiving signals collected by the sensor 11, the data processing unit 12 is used for Executing instructions to implement the method described in any one of the above-mentioned continuous blood glucose monitoring system control methods.

Wherein, the sensor 11 may adopt an existing blood glucose sensor, such as an electrochemical blood glucose sensor and the like. Data processing unit 12 may include one or more processing cores. The data processing unit 12 can be at least one of a specific application integrated circuit, a digital signal processor, a digital signal processing device, a programmable logic device, a field programmable gate array, a central processing unit, a controller, a microcontroller and a microprocessor kind. It can be understood that, for different devices, the electronic device used to realize the functions of the above-mentioned data processing unit 12 may also be other.

The above description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present application will not be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (10)

1. A method of controlling a dynamic blood glucose monitoring system, comprising:

after the dynamic blood glucose monitoring system is awakened, a plurality of current values generated by the sensor in a preset period are immediately acquired according to a preset frequency;

judging whether an initial current value generated by the sensor is zero, if so, then: removing the initial current values from the current values to obtain a current value sequence, judging whether the current values in the current value sequence are sequentially increased, judging whether the number of the absolute values of the slopes of the current values in the current value sequence is not less than the preset absolute values of the slopes, and if yes, judging whether the number of the absolute values of the slopes of the current values in the current value sequence is not less than the preset number:

and controlling the dynamic blood glucose monitoring system to start blood glucose monitoring.

2. The method according to claim 1, wherein after judging that the current values in the current value series are sequentially increased and that the absolute value of the slope of the current values in the current value series is not less than the preset absolute value of the slope by not less than the preset number, further comprising:

judging whether slope values of a plurality of continuous current values in the current value sequence are unequal, and if yes, controlling the dynamic blood glucose monitoring system to start blood glucose monitoring.

3. The method of claim 2, wherein upon determining that the slope values of successive ones of the sequence of current values are not equal, further comprising:

judging whether the current value number ratio of the current value in the current value sequence in a preset current value interval containing the end points is not lower than a preset ratio, and if yes, controlling the dynamic blood glucose monitoring system to start blood glucose monitoring.

4. The method of claim 3, further comprising, after determining that the current value in the sequence of current values is within the preset current value interval including the endpoint, a number of current values having a ratio not lower than a preset ratio:

acquiring a first difference value number of which the current value difference value of adjacent current values in the current value sequence is not smaller than a preset difference value lower limit, and a second difference value number of which the current value difference value of adjacent current values in the current value sequence is not larger than a preset difference value upper limit;

judging whether the first difference value is not less than a first preset threshold value or not, and whether the second difference value is not less than a second preset threshold value or not, if yes, controlling the dynamic blood glucose monitoring system to start blood glucose monitoring.

5. The method of any one of claims 1-4, further comprising, after said controlling said dynamic blood glucose monitoring system to begin blood glucose monitoring:

Judging whether the total number of the glucose concentration values acquired by the dynamic blood glucose monitoring system exceeds a preset total number or judging whether the total time length of the current acquired by the dynamic blood glucose monitoring system exceeds a preset time length, and if one of the total time lengths is yes, controlling the dynamic blood glucose monitoring system to stop blood glucose monitoring.

6. The method of claim 1, wherein the preset slope absolute value and the preset number are determined by:

acquiring a plurality of detection current value sequences obtained by current detection of a plurality of sensors in an analog detection environment according to the preset frequency in the preset period and removing initial current values;

calculating the absolute value of the slope of each current value in each detected current value sequence to obtain a plurality of slope absolute value sequences;

respectively selecting the minimum value of the preset number of larger values in the absolute value of the slope from each absolute value sequence of the slope to obtain a absolute value selection sequence of the slope containing a plurality of minimum values;

selecting the minimum value in the sequence as the absolute value of the preset slope by using the absolute value of the slope;

wherein the preset number is any of 3, 4 or 5.

7. A method according to claim 3, wherein the preset current value interval and the preset duty cycle are determined by the steps of:

acquiring a plurality of detection current value sequences obtained by current detection of a plurality of sensors in an analog detection environment according to the preset frequency in the preset period and removing initial current values;

obtaining the minimum value in each detection current value sequence to form a lower limit sequence containing a plurality of current value minimum values;

obtaining the maximum value in each detection current value sequence to form an upper limit sequence containing a plurality of current value maximum values;

taking the minimum value in the lower limit sequence as the lower limit of the preset current value interval, and taking the maximum value in the upper limit sequence as the upper limit of the preset current value interval;

wherein the preset duty cycle is any value from 0.7 to 1.

8. The method of claim 4, wherein the lower preset difference limit and the upper preset difference limit are determined by:

acquiring a plurality of detection current value sequences obtained by current detection of a plurality of sensors in an analog detection environment according to the preset frequency in the preset period and removing initial current values;

Calculating the absolute difference values of all adjacent current values in each detection current value sequence to obtain a plurality of absolute difference value sequences;

respectively selecting a first minimum value of the first preset threshold values in the absolute value of the difference value from each absolute value sequence of the difference value to obtain a first sequence containing a plurality of first minimum values;

respectively selecting a first maximum value of the second preset threshold values in the absolute value of the difference value from each absolute value sequence of the difference value to obtain a second sequence containing a plurality of first maximum values;

and taking the minimum value in the first sequence as the preset difference lower limit and the maximum value in the second sequence as the preset difference upper limit.

9. The method of claim 8, wherein,

the first preset threshold is any value among 3, 4 and 5;

the second preset threshold is the number of current values in the sequence of current values minus 1.

10. A dynamic blood glucose monitoring system, comprising: a sensor and a data processing unit for receiving sensor acquisition signals, the data processing unit for executing instructions to implement the method of any one of claims 1 to 9.