CN116236550A - Light traditional Chinese medicine formula preparation for treating novel coronavirus infection and preparation method thereof - Google Patents
Light traditional Chinese medicine formula preparation for treating novel coronavirus infection and preparation method thereof Download PDFInfo
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Abstract
Description
技术领域technical field
本发明涉及一种治疗新型冠状病毒感染轻型的中药配方制剂及其制备方法,属于中药配方制备领域。The invention relates to a traditional Chinese medicine formula preparation for treating mild novel coronavirus infection and a preparation method thereof, belonging to the field of traditional Chinese medicine formula preparation.
背景技术Background technique
民间医药是中华民族长期同疾病作斗争的过程中产生的医药宝库,是我国现有中医药资源的重要组成部分,开发民间医药可为治疗常见病、多发病、疑难病等的治疗探寻新的药物组方。新型冠状病毒感染是一种传染性很强的传染病,冬季流行迅猛,新型冠状病毒感染轻型的临床表现主要有恶寒发热,肌肉酸痛,干咳,咳嗽痰少,痰粘难咯,咽痛,咽痒,口淡无味或食欲减退,纳差乏力,神疲体倦,腹泻,鼻塞流涕甚或嗅觉减退,眼痛眼痒甚或结膜炎。风与寒合,侵袭肺卫,故见恶寒、鼻塞流涕甚或嗅觉减退,郁而化热故见发热、咽痛;风寒挟湿,邪犯肌腠,故见肌肉酸痛,湿阻中焦,故见口淡无味或食欲减退、纳差乏力、神疲体倦、腹泻、恶心呕吐;风寒挟燥,邪气犯肺或郁而化热灼肺津生内燥致肺失宣肃,故见干咳、咳嗽痰少、痰粘难咯、咽痒;风寒湿燥犯肝经,故见眼痛眼痒眼干甚或结膜炎。当前中医治疗新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证的的民间中药药物相对较少,针对这一现状,探索开发治疗新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证提供不同配伍的中药药物,为治疗新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证选择药物提供新的途径。Folk medicine is a treasure house of medicine produced during the long-term struggle of the Chinese nation against diseases. It is an important part of my country's existing traditional Chinese medicine resources. The development of folk medicine can explore new methods for the treatment of common diseases, frequently-occurring diseases, and difficult diseases. Drug prescription. The new coronavirus infection is a highly contagious infectious disease, which spreads rapidly in winter. The mild clinical manifestations of the new coronavirus infection mainly include chills, fever, muscle aches, dry cough, cough with little sputum, sticky sputum, and sore throat. Itchy throat, tasteless mouth or loss of appetite, anorexia, fatigue, diarrhea, stuffy nose and runny nose or loss of sense of smell, sore and itchy eyes or even conjunctivitis. Wind and cold combine to attack the lungs and guards, resulting in aversion to cold, runny nose or even hyposmia, fever and sore throat due to stagnation and heat transformation; wind and cold combined with dampness, evils invade the muscles and interstitial areas, resulting in muscle aches, dampness blocking the middle burner , so see tasteless mouth or loss of appetite, anorexia, fatigue, fatigue, diarrhea, nausea and vomiting; wind-cold dryness, evil qi attacking the lungs or stagnation and heat burning in the lungs and body fluid, resulting in internal dryness of the lungs, so see Dry cough, cough with little phlegm, sticky phlegm, itchy throat; wind, cold, dampness and dryness violate the liver meridian, so eye pain, itching, dry eyes or even conjunctivitis can be seen. At present, there are relatively few folk traditional Chinese medicines for the treatment of mild cases of new coronavirus infection and the syndrome of wind-cold and dampness and dryness in the common cold. Provide different compatibility of traditional Chinese medicines, and provide a new way to choose medicines for the treatment of mild cases of new coronavirus infection and common cold syndrome of wind-cold with dampness and dryness.
发明内容Contents of the invention
本发明所要解决的是为治疗新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证选择药物提供新途径的技术问题。What the present invention aims to solve is the technical problem of providing a new way to select medicines for the treatment of light-type novel coronavirus infection and common cold syndrome of wind-cold with dampness and dryness.
为了解决上述技术问题,本发明采用如下技术方案:In order to solve the above technical problems, the present invention adopts the following technical solutions:
治疗新型冠状病毒感染轻型的中药配方制剂,原料及重量配比分别为:夜寒苏2份、麒麟草2份、鸡屎藤1份、苦荞头1份、红景天1份、山银花叶1份、岩白菜1份、蛹虫草1份、苦杏仁0.75份。The traditional Chinese medicine formula preparation for treating mild cases of novel coronavirus infection, raw materials and weight ratios are: 2 parts of Yehansu, 2 parts of Eurytheca chinensis, 1 part of Caulis chinensis, 1 part of tartary buckwheat head, 1 part of rhodiola rosea, and mountain silver flower leaves 1 part, 1 part rock cabbage, 1 part Cordyceps militaris, 0.75 part bitter almond.
治疗新型冠状病毒感染轻型的中药配方制剂的制备方法,包括如下步骤:The preparation method of the traditional Chinese medicine formula preparation for the treatment of light novel coronavirus infection comprises the following steps:
步骤一:将夜寒苏2份、麒麟草2份、鸡屎藤1份、苦荞头1份、红景天1份、山银花叶1份、岩白菜1份、蛹虫草1份、苦杏仁0.75份投入粉碎机中粉碎达120目以上,过七号筛既得混合粉状物备用;Step 1: Take 2 parts of Yehansu, 2 parts of Eurytheca militaris, 1 part of Gallus chinensis, 1 part of tartary buckwheat head, 1 part of Rhodiola rosea, 1 part of mountain silver flower leaves, 1 part of rock cabbage, 1 part of Cordyceps militaris, and bitter almonds Put 0.75 parts into the pulverizer and pulverize to more than 120 mesh, and pass through the No. 7 sieve to obtain the mixed powder for later use;
步骤二:将步骤一所得混合粉状物分装每小包6克封装入聚乙烯塑料袋中密封。Step 2: Divide the mixed powder obtained in Step 1 into 6 grams per packet and seal it in a polyethylene plastic bag.
所述混合粉状物, 与相应的药用辅料配伍, 可制成胶囊剂、 片剂、 丸剂、 冲剂及颗粒剂,包装为每袋6克。The mixed powder, compatible with corresponding pharmaceutical excipients, can be made into capsules, tablets, pills, granules and granules, and the packaging is 6 grams per bag.
采用本中药的配方制剂的有益效果:The beneficial effect of adopting the formula preparation of this Chinese medicine:
本发明为发掘祖国医学和丰富祖国医药学具有积极意义,可广泛用于新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证,为治疗新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证增加了有效方便安全经济适宜的治疗药物,并具有疗效好的特点,储存运输方便;配方多来自民间中草药,目前各家中医医疗机构使用较少,药源丰富有一定的保障。价格较低亷,为新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证的患者提供安全、经济、方便、适宜的选择用药的新途径。The present invention is of positive significance for discovering the traditional Chinese medicine and enriching the medical science of the motherland, and can be widely used for mild cases of novel coronavirus infection and common cold with wind-cold dampness and dryness, and for the treatment of mild cases of novel coronavirus infection and common cold with wind-cold dampness and dryness. The syndrome has added effective, convenient, safe, economical and suitable therapeutic drugs, which have the characteristics of good curative effect and are convenient for storage and transportation; most of the formulas come from folk Chinese herbal medicines, which are rarely used by various Chinese medical institutions at present, and the rich sources of medicines have a certain guarantee. The price is relatively low, and it provides a safe, economical, convenient and suitable new way to choose medication for patients with mild new coronavirus infection and common cold with dampness and dryness syndrome.
具体实施方式Detailed ways
下面对本发明作进一步详细说明:The present invention is described in further detail below:
治疗新型冠状病毒感染轻型的中药配方制剂,原料及重量配比分别为:夜寒苏2份、麒麟草2份、鸡屎藤1份、苦荞头1份、红景天1份、山银花叶1份、岩白菜1份、蛹虫草1份、苦杏仁0.75份。The traditional Chinese medicine formula preparation for treating mild cases of novel coronavirus infection, raw materials and weight ratios are: 2 parts of Yehansu, 2 parts of Eurytheca chinensis, 1 part of Caulis chinensis, 1 part of tartary buckwheat head, 1 part of rhodiola rosea, and mountain silver flower leaves 1 part, 1 part rock cabbage, 1 part Cordyceps militaris, 0.75 part bitter almond.
治疗新型冠状病毒感染轻型的中药配方制剂的制备方法,包括如下步骤:The preparation method of the traditional Chinese medicine formula preparation for the treatment of light novel coronavirus infection comprises the following steps:
步骤一:将夜寒苏2份、麒麟草2份、鸡屎藤1份、苦荞头1份、红景天1份、山银花叶1份、岩白菜1份、蛹虫草1份、苦杏仁0.75份投入粉碎机中粉碎达120目以上,过七号筛既得混合粉状物备用;Step 1: Take 2 parts of Yehansu, 2 parts of Eurytheca militaris, 1 part of Gallus chinensis, 1 part of tartary buckwheat head, 1 part of Rhodiola rosea, 1 part of mountain silver flower leaves, 1 part of rock cabbage, 1 part of Cordyceps militaris, and bitter almonds Put 0.75 parts into the pulverizer and pulverize to more than 120 mesh, and pass through the No. 7 sieve to obtain the mixed powder for later use;
步骤二:将步骤一所得混合粉状物分装每小包6克封装入聚乙烯塑料袋中密封。Step 2: Divide the mixed powder obtained in Step 1 into 6 grams per packet and seal it in a polyethylene plastic bag.
所述混合粉状物, 与相应的药用辅料配伍, 可制成胶囊剂、 片剂、 丸剂、 冲剂及颗粒剂,包装为每袋6克。The mixed powder, compatible with corresponding pharmaceutical excipients, can be made into capsules, tablets, pills, granules and granules, and the packaging is 6 grams per bag.
本发明的中药配方制剂的功效为解表清里,健脾化痰,润肺止咳,用于符合《新型冠状病毒感染诊疗方案(试行第十版)》中新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证的患者。症见恶寒发热(体温<38.5℃),肌肉酸痛,干咳,咳嗽痰少,痰粘难咯,咽痛,咽痒,口淡无味或食欲减退,纳差乏力,鼻塞流涕甚或嗅觉减退,舌红或淡红,苔黄腻或白、白腻,脉浮紧、浮或浮数。The efficacy of the traditional Chinese medicine formula preparation of the present invention is to relieve the exterior and clear the interior, invigorate the spleen and resolve phlegm, moisten the lungs and relieve cough, and is used for mild cases of novel coronavirus infection and common cold with wind-cold Patients with syndrome of dampness and dryness. Symptoms include aversion to cold and fever (body temperature < 38.5°C), muscle aches, dry cough, cough with little sputum, sticky sputum, sore throat, itchy throat, tasteless mouth or loss of appetite, anorexia and fatigue, nasal congestion and runny nose or even loss of sense of smell. Red or light red tongue, yellow greasy or white, white greasy fur, floating tight, floating or floating pulse.
用法用量: 12岁以上儿童及成人每次6-9克,6-12岁儿童每次3-6g, 每日3次,饭后服用。若有眼痛眼痒眼干甚或结膜炎患者用菊花、石斛各10g泡水吞服本制剂6-9克,饭后服用。禁忌症:禁用于妊娠期妇女、《新型冠状病毒感染诊疗方案(试行第十版)》危重型,慎用于体温>38.5℃、发热>3天、基础病有靶器官损伤者、基础病控制不良者、婴幼儿、《新型冠状病毒感染诊疗方案(试行第十版)》中型、重型。Usage and dosage: Children over 12 years old and adults take 6-9 grams each time, children 6-12 years old take 3-6g each time, 3 times a day, take after meals. If the patient has eye pain, itching, dry eyes or even conjunctivitis, soak 10 g of chrysanthemum and dendrobium in water and swallow 6-9 grams of this preparation, and take it after meals. Contraindications: contraindicated in pregnant women, critically ill according to "Diagnosis and Treatment Plan for Novel Coronavirus Infection (Trial Version 10), use with caution in patients with body temperature > 38.5°C, fever > 3 days, underlying disease with target organ damage, underlying disease control Poor patients, infants, medium and severe cases according to the Diagnosis and Treatment Plan for Novel Coronavirus Infection (Trial Version 10).
新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证因风与寒合,侵袭肺卫,故见恶寒、鼻塞流涕甚或嗅觉减退,郁而化热故见发热、咽痛;风寒挟湿,邪犯肌腠,故见肌肉酸痛、头身疼痛,湿阻中焦,故见口淡无味或食欲减退、纳差乏力、神疲体倦、腹泻、恶心呕吐;风寒挟燥,邪气犯肺或郁而化热灼肺津生内燥致肺失宣肃,故见干咳、咳嗽痰少、痰粘难咯、咽痒;风寒湿燥犯肝经,故见眼痛眼痒眼干甚或结膜炎。配方中夜寒苏解表散寒,祛风止痛,温中健胃能散邪外出为君药;麒麟草(加拿大一支黄花)清热解毒祛湿能清里,现代药理证实其有镇痛、镇咳、祛痰、抗氧化、抗炎的药理作用,为臣药;鸡屎藤健胃消食、化痰止咳、清热解毒、止痛以佐助改善新型冠状病毒所致发热、咽痛、咳嗽咳痰、头身痛、口淡无味或食欲减退、纳差乏力、神疲体倦、恶心呕吐,苦荞头(金荞麦)健脾消食、清热解毒、排脓祛瘀以佐助改善新型冠状病毒所致发热、咽痛、咳嗽咳痰、头身痛、口淡无味或食欲减退、纳差乏力、神疲体倦、恶心呕吐,红景天健脾益气、清肺止咳、活血化瘀佐助以改善新型冠状病毒所致咳嗽咳痰、头身痛、口淡无味或食欲减退、纳差乏力、神疲体倦、恶心呕吐,其具有抗疲劳、抗缺氧的作用,三药均有健脾之功,以培土生金,促进饮食,保证人体营养充足,达到提高免疫力的作用;山银花叶清热解毒以改善郁而化热,现代药理证实有良好的抗病毒作用;岩白菜润肺止咳达到润燥的作用;蛹虫草补益肺肾、止咳止血,具有改善免疫的作用;苦杏仁润而止咳平喘,入肺经而引经。诸药共用以解表清里,健脾化痰,润肺止咳,用于符合《新型冠状病毒感染诊疗方案(试行第十版)》中新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证的患者。症见恶寒发热(体温<38.5℃),肌肉酸痛,干咳,咳嗽痰少,痰粘难咯,咽痛,咽痒,口淡无味或食欲减退,纳差乏力,鼻塞流涕甚或嗅觉减退,舌红或淡红,苔黄腻或白、白腻,脉浮紧、浮或浮数。Novel coronavirus infection mild and common cold syndrome of wind-cold with dampness and dryness is due to the combination of wind and cold, invading the lungs and guards, so you can see aversion to cold, nasal congestion, runny nose, or even loss of sense of smell, and fever and sore throat due to depression and heat; wind-cold Dampness, the evil invades the muscles and interstitial spaces, so you see muscle aches, head and body pain, dampness blocking the middle burner, so you see tasteless mouth or loss of appetite, anorexia, fatigue, fatigue, diarrhea, nausea and vomiting; The lungs or stagnation turn into heat, the lungs and fluids generate internal dryness, and the lungs lose their vibrancy, so dry cough, cough with less phlegm, sticky phlegm, and itchy throat; wind-cold, damp-dryness invades the liver meridian, so eye pain, itchy eyes, or even dry eyes Conjunctivitis. In the formula, Yehansu relieves exterior cold, dispels wind and relieves pain, warms the middle and invigorates the stomach, and can dispel evil spirits. The pharmacological effects of phlegm, anti-oxidation, and anti-inflammation are ministerial medicines; the medicinal effect of chicken dung vine is to invigorate the stomach and eliminate food, reduce phlegm and relieve cough, clear away heat and detoxify, and relieve pain to help improve fever, sore throat, cough, sputum, head and body pain caused by the new coronavirus , tasteless mouth or loss of appetite, anorexia, fatigue, fatigue, nausea and vomiting, tartary buckwheat (golden buckwheat) invigorates the spleen and eliminates food, clears heat and detoxification, drains pus and removes blood stasis to help improve fever, sore throat, Cough and sputum, head and body pain, tasteless mouth or loss of appetite, anorexia, fatigue, fatigue, nausea and vomiting, rhodiola invigorates the spleen and replenishes qi, clears the lungs and relieves cough, promotes blood circulation and removes blood stasis to help improve the symptoms caused by the new coronavirus Cough and sputum, head and body pain, tasteless mouth or loss of appetite, anorexia, fatigue, fatigue, nausea and vomiting, it has anti-fatigue and anti-hypoxia effects. All three drugs have the effect of invigorating the spleen. Gold, promote diet, ensure adequate nutrition of the human body, and achieve the effect of improving immunity; mountain silver flower leaves clear away heat and detoxify to improve stagnation and heat, modern pharmacology has proved to have a good antiviral effect; rock cabbage moistens the lungs and relieves cough to achieve the effect of moistening dryness ; Cordyceps militaris nourishes the lungs and kidneys, relieves cough and stops bleeding, and has the effect of improving immunity; Bitter almond moisturizes and relieves cough and asthma, enters the lung meridian and induces the meridian. All the medicines are used together to relieve the exterior and clear the interior, invigorate the spleen and resolve phlegm, moisten the lungs and relieve cough, and are used to meet the symptoms of mild new coronavirus infection and common cold with dampness and dryness in the "Diagnosis and Treatment Scheme for Novel Coronavirus Infection (Trial Version 10)" of patients. Symptoms include aversion to cold and fever (body temperature < 38.5°C), muscle aches, dry cough, cough with little sputum, sticky sputum, sore throat, itchy throat, tasteless mouth or loss of appetite, anorexia and fatigue, nasal congestion and runny nose or even loss of sense of smell. Red or light red tongue, yellow greasy or white, white greasy fur, floating tight, floating or floating pulse.
使用中药配方制剂冶疗新型冠状病毒感染轻型及普通感冒风寒挟湿、燥之证,以5-7日为一疗程,7-10天后观察疗效,症状消失为痊愈,症状改善或减少为有效,症状无改善或无减少为无效,其中治疗新型冠状病毒感染轻型患者56例,治愈及有效的病例51例,有效率91%;治疗普通感冒挟湿、燥之证的患者23例,治愈及有效的病例22例,有效率95%;详见下列典型病例:Use traditional Chinese medicine formula preparations to treat mild cases of new coronavirus infection and common cold with wind-cold dampness and dryness syndrome. The course of treatment is 5-7 days, and the curative effect is observed after 7-10 days. If the symptoms disappear, it is cured, and the symptoms are improved or reduced. No improvement or no reduction in symptoms is invalid. Among them, 56 cases of mild patients with new coronavirus infection were treated, 51 cases were cured and effective, and the effective rate was 91%. 22 cases, the effective rate is 95%; see the following typical cases for details:
姓 名 性别 年龄 诊断 疗效First name Gender Age Diagnosis Curative effect
曾** 男 40 新型冠状病毒感染轻型 痊愈Zeng** male 40 mild type of new coronavirus infection recovered
韩** 女 47 新型冠状病毒感染轻型 有效Han** female 47 mild type of new coronavirus infection effective
程** 男 57 新型冠状病毒感染轻型 痊愈Cheng** male 57 mild type of new coronavirus infection recovered
胡** 女 64 新型冠状病毒感染轻型 痊愈Hu ** female 64 mild type of new coronavirus infection recovered
曾** 男 65 新型冠状病毒感染轻型 痊愈Zeng** male 65 mild type of new coronavirus infection recovered
聂** 男 39 新型冠状病毒感染轻型 痊愈Nie** male 39 mild type of new coronavirus infection recovered
张** 女 87 新型冠状病毒感染轻型 有效Zhang** female 87 mild type of new coronavirus infection effective
张** 女 36 新型冠状病毒感染轻型 痊愈Zhang** female 36 mild type of new coronavirus infection recovered
曾** 男 12 新型冠状病毒感染轻型 痊愈Zeng** male 12 mild type of new coronavirus infection recovered
张** 男 65 新型冠状病毒感染轻型 痊愈Zhang** male 65 mild type of new coronavirus infection recovered
王** 男 38 新型冠状病毒感染轻型 有效Wang** male 38 mild type of new coronavirus infection effective
曾** 男 55 新型冠状病毒感染轻型 痊愈Zeng** male 55 mild type of new coronavirus infection recovered
邓** 女 55 新型冠状病毒感染轻型 痊愈Deng**, female 55, was mildly infected with the novel coronavirus and recovered
曾** 男 39 普通感冒风寒挟湿证 痊愈Zeng** male 39 common cold with wind-cold dampness syndrome recovered
胡** 女 61 普通感冒风寒挟燥证 痊愈Hu** female 61 common cold with wind-cold and dryness syndrome recovered
李** 女 41 新型冠状病毒感染轻型 无效。Li ** female 41 mild new type of coronavirus infection invalid.
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