CN1161866A - Nasal cavity medicine applicator - Google Patents
Nasal cavity medicine applicator Download PDFInfo
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- CN1161866A CN1161866A CN 97101939 CN97101939A CN1161866A CN 1161866 A CN1161866 A CN 1161866A CN 97101939 CN97101939 CN 97101939 CN 97101939 A CN97101939 A CN 97101939A CN 1161866 A CN1161866 A CN 1161866A
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- 239000003814 drug Substances 0.000 title claims abstract description 80
- 210000003928 nasal cavity Anatomy 0.000 title claims abstract description 70
- 239000002775 capsule Substances 0.000 claims abstract description 174
- 239000000843 powder Substances 0.000 claims abstract description 97
- 238000005507 spraying Methods 0.000 claims description 37
- 230000000717 retained effect Effects 0.000 claims description 15
- 239000007921 spray Substances 0.000 claims description 10
- 239000011295 pitch Substances 0.000 claims 3
- 238000000151 deposition Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 abstract description 26
- 238000012377 drug delivery Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 238000007789 sealing Methods 0.000 description 9
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000002788 crimping Methods 0.000 description 6
- 230000002093 peripheral effect Effects 0.000 description 6
- 239000004033 plastic Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 238000004891 communication Methods 0.000 description 2
- 239000013536 elastomeric material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
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Abstract
一种鼻腔给药器，它包括带有包含粉末状药物的胶囊的胶囊夹持部分。供气部分与胶囊夹持部分的下端连接，并作出一个与胶囊放置腔连通的供气通道。分支通道部分与胶囊夹持部分的上端连接，并具有一个与胶囊放置腔连通的空气流动通道。空气流动通道分叉出来，形成第一和第二输出通道部分，它们一般呈Y形形状。第一和第二药粉通道作成使得从分支支通道部分送出的空气通过该通道流动，将胶囊中的药粉送入病人的左右鼻腔中。
A nasal drug delivery device includes a capsule holding portion with a capsule containing a powdered drug. The air supply part is connected with the lower end of the capsule clamping part, and forms an air supply channel communicating with the capsule placement cavity. The branch passage part is connected with the upper end of the capsule holding part, and has an air flow passage communicated with the capsule placement cavity. The air flow channel diverges to form first and second output channel portions, which are generally Y-shaped. The first and second medicine powder passages are formed so that the air sent from the branch branch passage part flows through the passages to send the medicine powder in the capsule into the left and right nasal cavities of the patient.
Description
The present invention relates to be applicable to, for example send into the administrator of powdered drug to patient's left and right sides nasal cavity.
Generally, the Therapeutic Method of sending into powdered drug by nasal cavity can be used for suffering from the nasal cavity anaphylaxis, the patient of asthma etc.In this Therapeutic Method, use special-purpose ejector or doser usually, in this doser, the capsule of filling powdered drug is placed in the medicine-storing cavity.Powdered drug in the capsule is sent in patient's the nasal cavity.In the provisional publication 59-34267 of Japan Patent number, announced an example of this ejector that is used for this Therapeutic Method.
This common ejector comprises a columnar injector body, makes a capsule placed cavity in the body, and the capsule that powdered drug is housed just is placed in this chamber.Air supply channel is connected with this capsule placed cavity.Do that on cylindrical injection device top a medicine spray-hole is arranged, the medicine in the capsule is injected in patient's the nasal cavity by this hole.The medicine spray-hole is communicated with the capsule placed cavity.Give the perforation of the capsule in the capsule placed cavity by the pin that the medicine spray-hole inserts.
When adopting this common ejector, import to patient that the operation of powdered drug is performed such: at first, the top (work has insecticide-spraying hole) of cylindrical injection body is inserted in patient's the nasal cavity.Then, air is sent into by air supply channel in the capsule of having bored a hole, and the medicine in the capsule is sent in patient's the nasal cavity by insecticide-spraying hole.In order to finish the process of sending into medicine to patient, needs alternately repeat this operation to patient's left and right sides nasal cavity.
Yet, there are some shortcomings in above-mentioned common ejector, promptly need just can finish process to patient's administration by alternately and repeatedly the top of columnar injector body being inserted left and right nasal cavity, therefore be difficult to the medicine of equal amount is sent into left nasal cavity and right nasal cavity, and at this moment need to repeat columnar injector body is inserted the operation of left and right sides nasal cavity.This becomes trouble and long time of administration action need the administration operation.
An object of the present invention is to provide a kind of improved nasal cavity medicine applicator, it can overcome the shortcoming of common ejector or nasal cavity medicine applicator existence effectively.
Another object of the present invention is that a kind of improved nasal cavity medicine applicator will be provided, and it can simplify the operation of sending into powdery medicine to patient's nasal cavity widely, might comprise that child and adult send into powdery medicine to various people simultaneously.
The nasal cavity medicine applicator of first aspect present invention comprises a capsule retained part, is used for the capsule that powdered drug is equipped with in clamping.The air feed part is sent to the capsule that is clamped in the capsule retained part with air.The air feed part is connected with the capsule retained part.Administrator does that first and second drug channels are arranged, and the air that branches away from gas supply part flows through this first and second drug channel, the medicine in the capsule is sent in patient's the left and right sides nasal cavity.First and second insecticide-spraying holes are communicated with first and second drug channels respectively.Medicine from first drug channel and the medicine that comes from second drug channel spray from first and second insecticide-spraying holes respectively.First and second insecticide-spraying holes have first and second axis respectively, their one 12～25 mm distance that separates each other.
The nasal cavity medicine applicator of second aspect present invention comprises a capsule retained part, and this part comprises that a formation deposits the device of the capsular capsule placed cavity that powdery medicine is housed.The air feed part is connected with first end of capsule retained part, and does that the air supply channel that is communicated with the capsule placed cavity is arranged, and it is sent to air the capsule that is clamped in the capsule retained part.Branched bottom partly makes the air flow passage that is communicated with the capsule placed cavity come out at branched bottom part bifurcated, to form first and second channel parts.Generally, air flow passage and first, second output channel are Y shape shape.The branched bottom part is connected with second end of capsule retained part.First and second drug channels make the air that partly comes out from branched bottom can be flowed therein, the medicine in the capsule are sent in patient's the left and right sides nasal cavity.First and second passages are communicated with first and second output channels of branched bottom part respectively.First and second insecticide-spraying holes are communicated with first and second drug channels respectively, and medicine from first drug channel and the medicine that comes from second drug channel spray from first and second insecticide-spraying holes respectively.First and second insecticide-spraying holes have first and second axis respectively, their one 12～25 mm distance that separates each other.
The nasal cavity medicine applicator of third aspect present invention comprises first and second drug channels, and they are communicated with patient's left and right sides nasal cavity.The first and second capsule placed cavities are respectively applied for stores first and second capsules that powdery medicine is housed.The first and second capsule placed cavities are communicated with first and second drug channels respectively, make medicine and the medicine in second capsule in first capsule can send into first and second drug channels respectively.Air feed is partly gone up and is made to have air supply channel, and the air that send is promptly by this channel flow.In administrator, be provided with the branched bottom part, make the air flow passage that is communicated with air supply channel partly punish fork and come, form the first and second output channel parts at branched bottom.This first and second output channel is communicated with the first and second capsule placed cavities respectively, and general air flow passage and first and second output channel partly are Y shape shape.Branched bottom partly is placed between the first and second capsule placed cavities, forms a device and air feed part.First and second insecticide-spraying holes are communicated with first and second drug channels respectively.Medicine from first drug channel and the medicine that comes from second drug channel spray from first and second insecticide-spraying holes respectively.First and second insecticide-spraying holes have first and second axis respectively, their one 12～25 mm distance that separates each other.
According to above each side of the present invention, give patient with the powdery medicine process in, air is sent to capsule from the gas supply part branch, and flows in the capsule, forms the air-flow that contains medicine.Then, the air communication that contains medicine is crossed the drug channel of right-hand member and left end, and the right nasal cavity and the left nasal cavity that spray into patient from the right side and the left side insecticide-spraying hole of nozzle segment.Like this, can simultaneously medicine be sent into two nasal cavities of patient, therefore can save with common administrator and alternately repeat ejector is inserted patient's left and right sides nasal cavity and repeatedly gives each nasal cavity medicine delivery.This can simplify the administration operation widely, shortens the required time of administration operation simultaneously.In addition, the center of the corresponding insecticide-spraying hole of nozzle segment (axis) is arranged in 12～25 millimeters scopes, therefore, insecticide-spraying hole can be placed in various patients' the nasal cavity respectively securely, comprises between nasal cavity apart from the bigger adult of distance between less child and nasal cavity.This makes and improves the effect of medicine simultaneously in the position that needs that medicine might be sent into each nasal cavity.
Fig. 1 is the vertical cross-section diagram according to first embodiment of nasal cavity medicine applicator of the present invention, and it represents first mode of operation of this administrator;
Fig. 2 is the exploded perspective view of the administrator of Fig. 1;
Fig. 3 is the vertical cross-section diagram similar to Fig. 1, second mode of operation of the administrator of its presentation graphs 1;
Fig. 4 is the vertical cross-section diagram similar to Fig. 1, but the 3rd mode of operation of the administrator of presentation graphs 1;
Fig. 5 is the vertical cross-section diagram according to second embodiment of nasal cavity medicine applicator of the present invention.
Referring to Fig. 1 to Fig. 4, first embodiment of reference number 1 expression nasal cavity medicine applicator, general, administrator 1 comprises a capsule clamper 2, it is made of plastics, and makes drum.Make to have external screw thread 3 on the external peripheral surface of the upper part of capsule clamper 2.Capsule clamper 2 makes and has bottom, a capsule hole 4, and it is axially extended, and opens wide in the upper end surface of capsule clamper 2.Bottom, capsule hole 4 is coaxial with capsule clamper 2.Capsule placed cavity 5 is formed at bottom, capsule hole 4 and 17 combinations of top, capsule hole, and top, capsule hole will be discussed afterwards.
Capsule placed cavity 5 is used to deposit and is generally columniform capsule K (as shown in Figure 2).Capsular volume is preferably 0.2～0.6 cubic centimetre (cc) in 0.1～1.4 cubic centimetre of (cc) scope.The powdery medicine of the right quantity of having packed among the capsule K (being called " medicated powder " later on).In addition, capsule placed cavity 5 is set at and makes its axial dimension L0 slightly smaller than the axial dimension Lk of capsule K, and like this, capsule K can leave in the capsule placed cavity 5 under the state of axial firm support.
The upper part of air feed part 6 and capsule clamper 2 integral body are made, and with the 2 coaxial extensions of capsule clamper.The end portion of air feed part 6 has air feed valve pocket 8, and it is communicated with by air flow passage 7 with pump 13 (discussing later on).Make to have valve opening amount restricted part 9 in air feed valve pocket 8, it is outstanding downwards from capsule clamper 2, and extends towards air supply channel 7.Air feed spool 10 is placed in the air feed valve pocket 8, and facing to valve opening amount restricted part 9, the two certain distance that is spaced from each other.Air feed spool 10 is positioned on the air flow passage 7, and when sending in the air from pump 13, can move upward, and contacts with valve opening amount restricted part 9, and the moving passage 7 of air is opened; Can be located in again on the bottom surface of air feed part 6 simultaneously, air supply channel 7 is closed.Air supply channel 11 is made on the top of air feed part 6.This passage 11 is at the core of air feed part 6, and extension vertically.The lower end of air supply channel 11 is communicated with the hole 12 of medicated powder receiving unit or horizontal expansion.Valve opening amount restricted part 9 is run through in this hole 12, extends in the diametric(al) of air feed part 6.When pin 27 was made through hole H on capsule K, medicated powder receiving unit 12 can receive from capsule and fall to medicated powder on the air feed spool 10.Pin 27 is made through hole H on capsule K situation is discussed later (see figure 3).
The upper end of air supply channel 11 is communicated with the bottom of bottom, capsule hole 4.The cross-sectional area of air supply channel 11 is at 0.2～6.0 square millimeter of (mm
2) in the scope.Be preferably 1.0～4.5 square millimeters of (mm
2).Like this, from an amount of air that pump 13 is sent, flow velocity that can be suitable flows among the capsule K, and with the good mixing ratio, the medicated powder among the capsule K is mixed with air.The cross-sectional area of air supply channel 11 can prevent that air supply channel 11 is by obstructions such as medicated powder.
Right-hand member and left end medicated powder passage 19,19 extend vertically, its upper end respectively with right-hand member and left end medicated powder spray- hole 20A, 20A connects.Each medicated powder passage 19 makes the shape of straight lengthening, so that adjustable characteristic of flow and straight ahead characteristic are provided for the medicated powder by each medicated powder passage 19, medicated powder can be ejected to being forced to property from each insecticide-spraying hole 20A.Insecticide- spraying hole 20A, 20A make by the medicated powder injection nozzle part 20,20 of right-hand member and left end respectively.This nozzle segment 20,20 highlights from the upper surface on the top of channel part 15.In order to insert each nasal cavity of patient easily, general, each injection nozzle part 20 all makes truncated cone shape.At the place, centre of injection nozzle part 20, make co-axial each insecticide-spraying hole 20A.This insecticide-spraying hole 20A extends vertically, is connected with medicated powder passage 19, and therefore, the air that contains medicated powder can be spurted in each nasal cavity of patient by insecticide-spraying hole 20A.
As shown in Figure 1, the medicated powder injection nozzle part 20,20 of right-hand member and left end has center or axis (not having number designation) respectively, and they separate the distance L 1 of 12～25 millimeters (mm).As a result, nozzle segment 20,20 can insert in various patient's the nasal cavity, comprises between the nasal cavity between the child of distance less (for example, 12～16 millimeters) and the nasal cavity the adult of big (for example, 16～22 millimeters) of distance.
As shown in Figure 3, perforator 25 is like this designs: as corresponding operation extension bar 26B, and 26B, according to the direction of Fig. 2 arrow A, when elongated hole 22 moved, syringe needle 27A inserted among the capsule K in the capsule placed cavity 5 vertically, forms through hole H, H on capsule K.Sealing member 29 is made by elastomeric material, and pin 27 slides relatively, and keeps the sealability for the medicated powder that flows through branched bottom part 18, can prevent that therefore medicated powder from infiltrating in the perforator chamber 21.
The mode of operation of first embodiment of nasal cavity medicine applicator 1 will be discussed below.
The perforation procedure of capsule K at first is described.
Capsule K is put into the bottom, capsule hole 4 of capsule clamper 2, make female thread 16 engagements of external screw thread 3 with the channel part 15 of capsule clamper 2 then, it is interior that capsule K just has been placed into capsule placed cavity 5 like this.This capsule placed cavity 5 comprises bottom, capsule hole 4 in the capsule clamper and top 17, capsule hole and the channel part 15 in the capsule clamper 2.
After this, depress the corresponding operation extension bar 26B of push pedal 26,26B, or make their direction motions according to Fig. 2 arrow A, make the syringe needle 27A of pin 27, by input channel part 18A, penetrate capsule K vertically, make through hole H, H in axial relative two sides of capsule K.At this moment, the medicated powder among the capsule K under the effect of the syringe needle 27A of pin 27, can fall into air supply channel 11.Medicated powder receiving unit 12 collects the medicated powder that falls into, thereby can prevent that medicated powder is bonded at and accumulates on the spool 10 of steam supply valve.
After the capsule perforation procedure, under the effect of return spring 28, push pedal 26 is back to its starting position automatically, like this, the channel part 18A of branched bottom part 18,18B, at through hole H, H does to be communicated with air supply channel 11 under the axially terminal relatively state of capsule K.
Below, illustrate after the perforation procedure of above-mentioned capsule K with reference to Fig. 4, to the operation of patient's administration.
At first, left and right sides medicated powder injection nozzle part 20,20 is inserted respectively in patient's the left and right sides nasal cavity.Then, according to arrow P, the crimping section 13C of the direction compressor pump 13 of P.Like this, when the opening of valves action of air feed spool 10 was opened air flow passage 7, air can be sent to the capsule K that is placed in the capsule placed cavity 5 by air supply channel 11.Correspondingly, the medicated powder among the capsule K is stirred, and is disseminated in the air.As a result, medicated powder mixes with air-flow, and by branched bottom part 18, flows into the medicated powder passage 19,19 of right-hand member and left end, and by the insecticide-spraying hole 20A of right-hand member and left end, 20A is injected in patient's nasal cavity then.
After above-mentioned administration operation, the crimping section 13C of pump 13 presses arrow R, and the direction of R returns to its initial state.At this moment, the spool 10 of steam supply valve is closed air flow passage 7, and spool 14B opens air suction passage 14A, and air is passed through air suction passage 14A from extraneous suction pump 13.
Therefore, administrator 1 according to this embodiment, by spray medicine nozzle segment 20 about setting, 20 insecticide-spraying hole 20A, distance L 1 between the 20A is 12～25 millimeters (mm), can be with corresponding insecticide- spraying hole 20A, 20A suitably puts between nasal cavity apart from the nasal cavity of less child to various people of the bigger adult of distance between the nasal cavity.As a result, medicated powder can be injected on the desired position of corresponding nasal cavity, thereby has improved the effect of medicine, has also expanded the scope of application of administrator 1 simultaneously.
Should be appreciated that the air flow that contains medicated powder that comes out from capsule K is to be dispensed in the medicated powder passage 19,19 of right-hand member and left end by branched bottom part 18, therefore can give medicated powder simultaneously, and the medicated powder amount of sending in the nasal cavity of the patient left and right sides is equal.The result, approximately only need No. three pumps 13 of compression, can give patient with the medicated powder in the capsule, and not need, repeat repeatedly administrator to be inserted the operation of the corresponding left and right sides of patient nasal cavity and the multiple dosing operation of each nasal cavity as using common administrator.Therefore, the administrator 1 of present embodiment can make the administration processing ease carry out, and has simplified the administration operation, also can shorten the required time of administration simultaneously.
In addition, the internal capacity of capsule K (content volume) is set in 0.1～1.4 cubic centimetre of (cc) scope.As a result, in the administration process, under the air-flow effect that flows into capsule K, the medicated powder in the capsule K can be supplied with patient fully, residue like this, can not supplied with patient with the medicated powder of the amount of being predetermined.This has improved the effect of medicine and the reliability of administrator 1 effectively.
In addition, the air-flow cross-sectional area of air supply channel 11 is set in 0.2～6.0 square millimeter of (mm
2) in the scope.As a result, flow that the air of sending from pump 13 can be suitable and speed flow into the capsule K, therefore, can prevent air supply channel 11 by obstructions such as medicated powder, simultaneously can the good mixing ratio, and the medicated powder among the capsule K is mixed with air.Correspondingly, medicated powder sprays into the state that can scatter effectively in patient's the nasal cavity, has therefore improved the effect of supplying with patient's medicine.
Moreover because manually operated pump 13 is connected with air feed part 6, air is sent in the air feed part 6, patient can be easy to form air-flow with finger compression crimping section 13C, therefore the administration processing ease is carried out.In addition, every compression once is set in 16～60 cubic centimetres of (cc) scopes from the air capacity of pump 13 outputs, therefore, suitable air capacity can be delivered to capsule K by air feed part 6, thereby improve the stirring efficiency of medicated powder in capsule K.
Fig. 5 represents second embodiment according to nasal cavity medicine applicator 1 ' of the present invention, and it is similar to the administrator of first embodiment.Part identical with first embodiment and element adopt identical reference number mark, therefore, for purposes of simplicity of explanation, have omitted the explanation of identical parts and element.The characteristics of this embodiment are that the capsule placed cavity is done respectively in the medicated powder passage of right-hand member and left end.
In this embodiment, nasal cavity medicine applicator 1 ' comprises air feed part 6, and it has the air feed valve pocket 8 that is communicated with pump 13 by air flow passage 7.Valve opening amount restricted part 9 is given prominence in valve pocket 8, and in the face of air flow passage 7.Air feed spool 10 is positioned at valve pocket 8, is used to open or close air flow passage 7.Air supply channel 11 extends axially, and is communicated with valve pocket 8 by medicated powder receiving unit 12.Medicated powder receive path 12 is positioned at the upstream of air supply channel 11, is used to collect the medicated powder that falls by air supply channel 11.
The upper end of air supply channel 11 is connected with branched bottom part 45.This branched bottom part 11 will be discussed afterwards.Identical with the administrator 1 of first embodiment, the cross-sectional area of air supply channel 11 is at 0.2～6.0 square millimeter of (mm
2) the interior variation of scope, be preferably 1.0～4.5 square millimeters of (mm
2).Like this, flow that the air of sending from pump 13 can be suitable and flow velocity flow into the capsule K, and the medicated powder among the capsule K than under is mixed in good mixing with air.
Above-mentioned branched bottom part 45 has right-hand member and left end output channel part 45A, 45A, and they come from the upper part branch of air supply channel 11.Each output channel part 45A extends upward obliquely, and is straight, and is therefore general, output channel part 45A, and 45A and air supply channel 11 are Y shape shape.Output channel 45A, the angle α between the axis of 45A is changing in 70 °～180 ° scopes on the vertical plane of the axis that comprises administrator 1 ', is preferably 90 °～160 °.Like this, the air of sending from air supply channel 11 generally equally is dispensed in the medicated powder passage 19,19 of right-hand member and left end, and the height of each output channel 45A reduces simultaneously, and the size of administrator 1 ' is reduced.
The medicated powder passage 19,19 of right-hand member and left end runs through whole capsule clamper 40 and nozzle member 43.Each medicated powder passage 19 extends axially from the output channel 45A of branched bottom part 45, passes capsule placed cavity 42, arrives right-hand member and left end insecticide-spraying hole 20A, each the insecticide-spraying hole 20A among the 20A.
Right-hand member and left end medicated powder nozzle segment 20,20 generally make truncated cone shape, and project upwards out from the upper surface of nozzle member 43.Each medicated powder nozzle segment 20 heart has therein partly been made insecticide-spraying hole 20A, and the air communication that contains medicated powder is crossed this hole ejection.The insecticide-spraying hole 20A of right-hand member and left end nozzle segment 20,20, the distance L 2 between the axis of 20A is set in 12～25 millimeters (mm) scopes.Therefore, nozzle segment 20,20 child that can insert between nasal cavity distance less (for example 12～16 millimeters) is to distance between the nasal cavity various people's of the adult of big (for example 16～22 millimeters) the nasal cavity.
First perforator 48 can move relative to capsule clamper 40, and comprises an operation annulus 49 on the external peripheral surface that movably is placed on air feed part 6.The lower end of two pins 50,50 or base part are fixed on the operation annulus 49, and protrude upward.The upper part of each pin 50 can be inserted in the capsule placed cavity 42.The upper end tip portion of each pin 50 makes sharp syringe needle 50A shape.First perforator 48 by moving its operation annulus 49, can be made through hole at axial relative two ends of the capsule K in being placed on each capsule placed cavity 42.
Two sealing members 51,51 are placed on the output channel part 45A of branched bottom part 45 respectively regularly, near the upper end of 45A.Each sealing member 51 cooperates with the recess of doing on capsule clamper 40 (not having numerical reference), and is made by elastomeric material (for example rubber or plastics).Each sealing member 51 can keep the sealing of not leaking medicated powder for pin 50.
Second perforator 52 separates with channel part 15, and comprises a grip portions 53.On the upper end of grip portions 53 or base part, fixing pin 54.The bottom of pin 54 makes the shape of sharp syringe needle 54A.Second perforator uses like this: pin 54 is by insecticide-spraying hole 20A, hold under the state of grip portions 53 with finger operator or patient, insert in the medicated powder passage 19 of each nozzle segment 20, therefore can make through hole H, H at axial relative two ends of capsule K.Should be appreciated that second perforator 52 can dispense.
The mode of operation of the administrator 1 ' of second embodiment will be discussed below.
Capsule K, K are placed on respectively in the capsule placed cavity 42,42 of right-hand member and left end.In this state, the operation annulus 49 of first perforator 48 moves up, or moves towards nozzle member 43, and respectively at two capsule K, axial relative two ends of K are made through hole H, H.
Then, the operation of giving patient's administration that above-mentioned capsule K perforation procedure is later is described.
At first, right-hand member and left end medicated powder nozzle segment 20,20 are inserted respectively in patient's the right nasal cavity and left nasal cavity.Then, compressor pump 13 is delivered to the capsule K that is placed on respectively in the capsule placed cavity 42,42 with air by air supply channel 11 and branched bottom part 45, among the K, stirs the medicated powder among the capsule K, and medicated powder is dispersed in the air.Like this, the medicated powder among the capsule K mixes with air, forms the air-flow that contains medicated powder, and by the channel part 45A of branched bottom part 45,45A sends in right-hand member and the left end medicated powder passage 19,19 then.Therefore, medicated powder is by the right-hand member and the left end insecticide-spraying hole 20A of medicated powder nozzle segment 20,20, and 20A sprays in patient's the right-hand member and left end nasal cavity.
Adopt the administrator 1 ' of this embodiment, generally can obtain same effect in the administrator 1 of first embodiment.In addition, according to this embodiment, the output channel part 45A of branched bottom part 45, form an angle [alpha] that in 70 °～180 ° scopes, changes between the 45A, therefore, the amount that the air of sending from air supply channel 11 generally can equate is dispensed in the medicated powder passage 19,19 of right-hand member and left end, and all supplies the medicated powder of equivalent can for each nasal cavity in the nasal cavity of the patient left and right sides.This has improved the reliability of the ejection efficiency and the nasal cavity medicine applicator of medicated powder.
Though represented and illustrated the administrator 1 of first and second embodiment, 1 ', their perforator 25,48th is placed in the channel part 15, and utilizes pin 27,50 pairs of capsules carry out axial penetration, make and make through hole H at axial relative two ends of capsule K, H, however be appreciated that, through hole H, H also can utilize perforator shown in Figure 5 52 to make.
Claims (9)
1. a nasal cavity medicine applicator (1,1 '), it comprises:
A capsule retained part (2,40) is used for the capsule (K) that clamping comprises powdery medicine;
An air feed part (6) is used for air is sent to the capsule that is clamped in described capsule retained part, and described air feed part is connected with described capsule retained part;
A device that constitutes the first and second medicated powder passages (19,19), the air that dispenses out from gas supply part passes through this channel flow, and the medicated powder in the capsule is sent in the nasal cavity of the patient left and right sides;
One constitutes the first and second insecticide-spraying hole (20A, device 20A), they respectively with the described first and second medicated powder channel connections, medicated powder of sending from the described first medicated powder passage and the medicated powder of sending from the described second medicated powder passage spray from described first and second insecticide-spraying holes respectively, described first and second insecticide-spraying holes have first and second axis respectively, their separate each other distances of 12～25 millimeters (mm).
2. administrator as claimed in claim 1, it is characterized by, described air feed part (6) comprises the device that constitutes air supply channel (11), air is promptly by this channel flow, its feature also is, described administrator also comprises a branched bottom part (18,45), the air flow passage (18A) that is communicated with described air supply channel (11) pitches out in this passage punishment, forms first and second output channels part (18B, 18B, 45A, 45A), this passage respectively with the described first and second medicated powder channel connections, described air flow passage and the general Y-shaped shape of the described first and second output channel parts.
3. administrator as claimed in claim 1 is characterized by, and described capsule retained part (2,40) comprises and be configured for depositing capsular capsule placed cavity (5,42) that described capsular content volume is in 0.1～1.4 cubic centimetre of (cc) scope.
4. administrator as claimed in claim 1 is characterized by, and described air feed part (6) comprises the device that constitutes air supply channel (11), and air is sent in the capsule by this passage, and the cross-sectional area of described air supply channel is 0.2～6.0 square millimeter of (mm
2).
5. administrator as claimed in claim 1, it also comprises the pump (13) that partly is connected with described air feed, is used for air is delivered to capsule by described gas supply part branch.
6. administrator as claimed in claim 5 is characterized by, and described pump (13) is for the manual operation formula, and its air output is in 10～60 cubic centimetres of (cc) scopes.
7. administrator as claimed in claim 2 is characterized by, and forms the angle (α) of one 70 °～180 ° of scopes between first and second output channels part of described branched bottom part.
8. a nasal cavity medicine applicator (1), it comprises:
A capsule retained part (2), it comprises the capsule placed cavity that is configured for depositing the capsule (K) that comprises powdery medicine;
An air feed part (6), be used for air is sent to the capsule that is clamped in described capsule retained part, described air feed part is connected with first end of described capsule retained part, and comprises the device that forms air supply channel (11), and this device is communicated with described capsule placed cavity;
A branched bottom part (18,45), the air flow passage (18A) that is communicated with described capsule placed cavity pitches out in this passage punishment, form first and second output channels part (18B, 18B), described air flow passage and the general Y-shaped shape of the described first and second output channel parts, described branched bottom part is connected with second end of described capsule retained part;
One constitutes the first and second medicated powder passages (19,19) device, the air of partly sending from described branched bottom passes through this channel flow, medicated powder in the capsule is sent in patient's the left and right sides nasal cavity, the described first and second medicated powder passages are communicated with first and second output channels of described branched bottom part respectively; With
One constitutes the first and second insecticide-spraying hole (20A, device 20A), they respectively with the described first and second medicated powder channel connections, medicated powder of sending from the described first medicated powder passage and the medicated powder of sending from the described second medicated powder passage spray from described first and second insecticide-spraying holes respectively, described first and second insecticide-spraying holes have first and second axis respectively, their separate each other distances of 12～25 millimeters (mm).
9. a nasal cavity medicine applicator (1 '), it comprises:
A device that constitutes the first and second medicated powder passages (19,19), they are communicated with patient's left and right sides nasal cavity;
One constitutes the first and second capsule placed cavities (42,42) device, this chamber is respectively applied for deposits the first and second capsule (K that comprise powdery medicine, K), the described first and second capsule placed cavities respectively with the described first and second medicated powder channel connections, make medicated powder and the medicated powder in second capsule in first capsule send into the described first and second medicated powder passages respectively;
An air feed part (6), it comprises the device that constitutes air supply channel (11), the air that send is by this channel flow;
A branched bottom part (45), the air flow passage that is communicated with described air supply channel (11) pitches out in this passage punishment, form first and second output channels part (45A, 45A), they are communicated with the described first and second capsule placed cavities respectively, described air flow passage and described first and second output channels part generally are Y shape shapes, and described branched bottom partly is placed between the described first and second capsule placed cavities, forms a device and described air feed part; With
One constitutes the first and second insecticide-spraying hole (20A, device 20A), they respectively with the described first and second medicated powder channel connections, medicated powder of sending from the described first medicated powder passage and the medicated powder of sending from the described second medicated powder passage spray from described first and second insecticide-spraying holes respectively, described first and second insecticide-spraying holes have first and second axis respectively, their separate each other distances of 12～25 millimeters (mm).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97101939 CN1161866A (en) | 1996-03-21 | 1997-03-21 | Nasal cavity medicine applicator |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP092023/96 | 1996-03-21 | ||
| CN 97101939 CN1161866A (en) | 1996-03-21 | 1997-03-21 | Nasal cavity medicine applicator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1161866A true CN1161866A (en) | 1997-10-15 |
Family
ID=5166063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97101939 Pending CN1161866A (en) | 1996-03-21 | 1997-03-21 | Nasal cavity medicine applicator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1161866A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102753228A (en) * | 2009-12-08 | 2012-10-24 | 美德英文特有限公司 | Methods for nasal irrigation and administration |
| CN103635218A (en) * | 2011-01-31 | 2014-03-12 | 株式会社新日本科学 | Intranasal delivery devices |
| CN103635218B (en) * | 2011-01-31 | 2016-11-30 | 株式会社新日本科学 | intranasal delivery device |
| CN106456914A (en) * | 2014-03-10 | 2017-02-22 | 英斯皮罗医药有限公司 | Active dry powder inhaler |
| CN109219462A (en) * | 2016-07-07 | 2019-01-15 | 菲利普莫里斯生产公司 | Nicotine particle delivery consumptive material |
| CN109364359A (en) * | 2018-11-27 | 2019-02-22 | 周毅 | A kind of nasal cavity chemical spraying device |
| CN109939326A (en) * | 2019-04-18 | 2019-06-28 | 首都医科大学附属北京安贞医院 | Smell training device based on expiratory pressure |
-
1997
- 1997-03-21 CN CN 97101939 patent/CN1161866A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102753228A (en) * | 2009-12-08 | 2012-10-24 | 美德英文特有限公司 | Methods for nasal irrigation and administration |
| CN102753228B (en) * | 2009-12-08 | 2014-10-08 | 美德英文特有限公司 | Methods for nasal irrigation and administration |
| CN103635218A (en) * | 2011-01-31 | 2014-03-12 | 株式会社新日本科学 | Intranasal delivery devices |
| CN103635218B (en) * | 2011-01-31 | 2016-11-30 | 株式会社新日本科学 | intranasal delivery device |
| US10071211B2 (en) | 2011-01-31 | 2018-09-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| CN106456914A (en) * | 2014-03-10 | 2017-02-22 | 英斯皮罗医药有限公司 | Active dry powder inhaler |
| CN109219462A (en) * | 2016-07-07 | 2019-01-15 | 菲利普莫里斯生产公司 | Nicotine particle delivery consumptive material |
| US10945460B2 (en) | 2016-07-07 | 2021-03-16 | Philip Morris Products S.A. | Nicotine particle delivery consumable |
| CN109364359A (en) * | 2018-11-27 | 2019-02-22 | 周毅 | A kind of nasal cavity chemical spraying device |
| CN109364359B (en) * | 2018-11-27 | 2021-03-26 | 孔静 | Medicine device is spouted to nasal cavity |
| CN109939326A (en) * | 2019-04-18 | 2019-06-28 | 首都医科大学附属北京安贞医院 | Smell training device based on expiratory pressure |
| CN109939326B (en) * | 2019-04-18 | 2023-10-31 | 首都医科大学附属北京安贞医院 | Olfactory training device based on expiratory pressure |
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Inventor after: Great wooden Dragon Inventor after: Nakamura Shigeki Inventor after: Stone standard Inventor after: Liu Chuanming Inventor after: Each row Inventor before: Great wooden Dragon Inventor before: Middle village Mao already Inventor before: Stone standard Inventor before: Liu Chuanming |
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Free format text: CORRECT: INVENTOR; FROM: DAMU OKI; ZHONGCUNMAOYI; YIZE SHIHKUAN; LIU CHUANMING TO: DAMU OKI; ZHONG VILLAGE; YIZE SHIHKUAN; LIU CHUANMING; JAR-SHING |
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