CN1161345C - 作为cck-a受体激动剂的1,5-苯并二氮杂�衍生物 - Google Patents

作为cck-a受体激动剂的1,5-苯并二氮杂�衍生物 Download PDF

Info

Publication number: CN1161345C
Authority: CN; China
Prior art keywords: compound; cck; phenyl; enantiomorph; solution
Prior art date: 1999-05-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CNB008099324A

Other languages

English (en)

Chinese (zh)

Other versions

CN1362949A (zh

Inventor

D��ƶ��˹

D·科尔克洛

¸�ɭ

A·霍德格森

Ŀ�

J·R·塞夫茨克

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Group Ltd

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-06

Filing date

2000-05-04

Publication date

2004-08-11

1999-05-06 Priority claimed from GBGB9910366.5A external-priority patent/GB9910366D0/en

2000-04-05 Priority claimed from GBGB0008179.4A external-priority patent/GB0008179D0/en

2000-05-04 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2002-08-07 Publication of CN1362949A publication Critical patent/CN1362949A/zh

2004-08-11 Application granted granted Critical

2004-08-11 Publication of CN1161345C publication Critical patent/CN1161345C/zh

2020-05-04 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CNB008099324A 1999-05-06 2000-05-04 作为cck-a受体激动剂的1,5-苯并二氮杂�衍生物 Expired - Fee Related CN1161345C (zh)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9910366.5A GB9910366D0 (en)	1999-05-06	1999-05-06	1,5-Benzodiazepine Derivatives
GB9910366.5		1999-05-06
GB0008179.4		2000-04-05
GBGB0008179.4A GB0008179D0 (en)	2000-04-05	2000-04-05	Chemical process

Publications (2)

Publication Number	Publication Date
CN1362949A CN1362949A (zh)	2002-08-07
CN1161345C true CN1161345C (zh)	2004-08-11

Family

ID=26244033

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CNB008099324A Expired - Fee Related CN1161345C (zh)	1999-05-06	2000-05-04	作为cck-a受体激动剂的1,5-苯并二氮杂�衍生物

Country Status (21)

Country	Link
EP (1)	EP1212305A2 (fr)
JP (1)	JP2002544200A (fr)
KR (1)	KR20020012567A (fr)
CN (1)	CN1161345C (fr)
AR (1)	AR022044A1 (fr)
AU (1)	AU4754800A (fr)
BR (1)	BR0010338A (fr)
CA (1)	CA2370801A1 (fr)
CO (1)	CO5170461A1 (fr)
CZ (1)	CZ20013988A3 (fr)
HK (1)	HK1046138A1 (fr)
HU (1)	HUP0201181A3 (fr)
IL (1)	IL146124A0 (fr)
MX (1)	MXPA01011267A (fr)
MY (1)	MY138319A (fr)
NO (1)	NO20015397D0 (fr)
NZ (1)	NZ515048A (fr)
PE (1)	PE20010110A1 (fr)
PL (1)	PL351546A1 (fr)
TR (1)	TR200103169T2 (fr)
WO (1)	WO2000068209A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005035793A2 (fr) *	2003-10-09	2005-04-21	Decode Genetics Ehf.	Marqueurs et haplotypes de cckar associes a des etats d'excedent de poids
JP4069159B2 (ja)	2004-05-25	2008-04-02	ファイザー・プロダクツ・インク	テトラアザベンゾ［ｅ］アズレン誘導体及びそれらのアナログ
KR20220150270A (ko)	2019-10-07	2022-11-10	칼리오페, 인크.	Gpr119 효능제
JP7745559B2 (ja)	2020-02-28	2025-09-29	キャリーオペ，インク．	Ｇｐｒ４０アゴニスト

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9307833D0 (en) *	1993-04-15	1993-06-02	Glaxo Inc	Modulators of cholecystokinin and gastrin

2000
- 2000-05-03 AR ARP000102119A patent/AR022044A1/es unknown
- 2000-05-04 PE PE2000000415A patent/PE20010110A1/es not_active Application Discontinuation
- 2000-05-04 CN CNB008099324A patent/CN1161345C/zh not_active Expired - Fee Related
- 2000-05-04 CA CA002370801A patent/CA2370801A1/fr not_active Abandoned
- 2000-05-04 MX MXPA01011267A patent/MXPA01011267A/es not_active Application Discontinuation
- 2000-05-04 AU AU47548/00A patent/AU4754800A/en not_active Abandoned
- 2000-05-04 CZ CZ20013988A patent/CZ20013988A3/cs unknown
- 2000-05-04 WO PCT/EP2000/003982 patent/WO2000068209A2/fr not_active Ceased
- 2000-05-04 HK HK02107684.4A patent/HK1046138A1/zh unknown
- 2000-05-04 NZ NZ515048A patent/NZ515048A/xx unknown
- 2000-05-04 TR TR2001/03169T patent/TR200103169T2/xx unknown
- 2000-05-04 BR BR0010338-1A patent/BR0010338A/pt not_active IP Right Cessation
- 2000-05-04 IL IL14612400A patent/IL146124A0/xx unknown
- 2000-05-04 MY MYPI20001917A patent/MY138319A/en unknown
- 2000-05-04 JP JP2000617189A patent/JP2002544200A/ja active Pending
- 2000-05-04 CO CO00031982A patent/CO5170461A1/es not_active Application Discontinuation
- 2000-05-04 EP EP00929488A patent/EP1212305A2/fr not_active Withdrawn
- 2000-05-04 KR KR1020017014075A patent/KR20020012567A/ko not_active Withdrawn
- 2000-05-04 HU HU0201181A patent/HUP0201181A3/hu unknown
- 2000-05-04 PL PL00351546A patent/PL351546A1/xx not_active Application Discontinuation
2001
- 2001-11-05 NO NO20015397A patent/NO20015397D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR0010338A (pt)	2002-02-13
NO20015397L (no)	2001-11-05
AR022044A1 (es)	2002-09-04
AU4754800A (en)	2000-11-21
CA2370801A1 (fr)	2000-11-16
MY138319A (en)	2009-05-29
WO2000068209A3 (fr)	2001-03-01
JP2002544200A (ja)	2002-12-24
PL351546A1 (en)	2003-05-05
CZ20013988A3 (cs)	2002-02-13
HUP0201181A2 (hu)	2002-12-28
NO20015397D0 (no)	2001-11-05
CO5170461A1 (es)	2002-06-27
MXPA01011267A (es)	2002-05-06
CN1362949A (zh)	2002-08-07
WO2000068209A2 (fr)	2000-11-16
HK1046138A1 (zh)	2002-12-27
HUP0201181A3 (en)	2003-10-28
IL146124A0 (en)	2002-07-25
EP1212305A2 (fr)	2002-06-12
KR20020012567A (ko)	2002-02-16
PE20010110A1 (es)	2001-03-05
TR200103169T2 (tr)	2002-04-22
NZ515048A (en)	2004-01-30

Publication	Publication Date	Title
CN1065536C (zh)	2001-05-09	2－甲基－噻吩并苯并二氮杂䓬的结晶形式及制备方法
US5585376A (en)	1996-12-17	1,5-benzodiazepine derivatives having CCK and/or gastrin antagonistic activity
CN1031051C (zh)	1996-02-21	环烷基取代的戊二酰胺衍生物的制备
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CN1414962A (zh)	2003-04-30	用于治疗中枢神经系统疾病的[(吲哚－3－基)－环烷基]－3－取代的氮杂环丁烷
CN1374956A (zh)	2002-10-16	1－环氨基－烷基环己烷化合物、其药物组合物及其作为抗惊厥药的用途
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CN1104018A (zh)	1995-06-21	取代的(芳烷基氨基苄基)氨基丙酰胺衍生物及其制备方法
US5399565A (en)	1995-03-21	Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations therof
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CN1193973A (zh)	1998-09-23	[1,2,4]三唑并[4,3－α]喹喔啉酮衍生物,其制备和用途

Legal Events

Date	Code	Title
2002-07-17	C10	Entry into substantive examination
2002-07-17	SE01	Entry into force of request for substantive examination
2002-08-07	C06	Publication
2002-08-07	PB01	Publication
2004-08-11	C14	Grant of patent or utility model
2004-08-11	GR01	Patent grant
2007-07-11	C19	Lapse of patent right due to non-payment of the annual fee
2007-07-11	CF01	Termination of patent right due to non-payment of annual fee