CN116099029A - A kind of disposable postoperative dressing plant concentrated film and its preparation method - Google Patents

Abstract

The invention provides a disposable postoperative dressing plant concentrating film and a preparation method thereof, wherein the concentrating film comprises extracted plant concentrated solution and auxiliary materials, and also comprises materials, wherein the dressing plant concentrating film adopts the synergistic effect of the extracted plant concentrated solution and the auxiliary materials and the materials, has obviously enhanced combined antibacterial effect, small irritation and no toxic or side effect, promotes the wound surface to heal quickly, promotes the recovery of skin barrier function, and simultaneously avoids the formation of serious scars at the wound surface.

Description

A kind of disposable postoperative dressing plant concentrated film and its preparation method

technical field

The invention relates to the technical field of medical dressings, in particular to a disposable postoperative dressing plant concentrated film and a preparation method thereof.

Background technique

The skin is the first line of defense to prevent the human body from being harmed by the external environment. It can maintain normal physiological functions such as temperature regulation, stimulation, absorption and excretion, and immune regulation. When the skin is damaged by mechanical and chemical stimuli from the external environment, it will not only bring physical and mental damage to people, but also bring economic burden and pressure to people. Wound healing is a complex process. After trauma, with the participation and interaction of cells and cytokines in the body, it goes through four dynamic repair stages of blood coagulation, inflammation, tissue proliferation, and remodeling. After the skin is traumatized, blood vessels rupture , platelets form blood clots in the damaged area to fill the damaged area, and at the same time, vasoconstriction reduces the amount of bleeding and the exudation of interstitial fluid, and enters the inflammatory stage. Immune cells such as macrophages and neutrophils will be recruited under the mediation of signals At the wound, growth factors are released after the cells and tissue fragments in the wound are removed, stimulating and inducing the growth and differentiation of fibroblasts and endothelial cells to generate new granulation tissue, and the new myofibroblasts pull the subcutaneous tissue toward the wound gradually Migrate to generate new epidermis to cover the wound. Modern medicine has conducted in-depth research on the process and mechanism of wound repair, as well as the cytokines that affect wound repair, and has a clearer theoretical basis and more treatment methods for wound repair.

At present, most medical dressings have the functions of covering protection, water absorption, moisturizing, and ventilation, which can meet the treatment needs of most wounds. However, different wound conditions have different requirements for dressings. Many dressings currently on the market have single performance, lack of biological activity and The combined treatment function is difficult to meet the physiological needs of wound healing, and the postoperative scar is severely hypertrophic, and it cannot achieve the effect of rapid wound healing and scar cure at the same time.

Contents of the invention

In view of this, the present invention proposes a disposable postoperative dressing plant concentrated film and a preparation method thereof to solve the above problems.

The technical solution of the present invention is achieved in the following way: a kind of disposable postoperative dressing plant concentrated film: comprising extracting plant concentrate and auxiliary materials, said extracting plant concentrate comprising the following raw materials in parts by weight: 1-2 parts of Flos Japonica , 1-3 parts of mugwort leaves, 1-1.5 parts of dandelion, 0.5-1.5 parts of safflower, 2-3 parts of gardenia, 2-3 parts of aloe; the auxiliary materials include the following raw materials in parts by weight: 0.5-0.8 parts of camphor, peppermint Brain 0.5-0.8 part, borneol 0.5-0.8 part, polyvinyl alcohol 0.2-0.3 part.

Further, the extracting plant concentrate includes the following raw materials in parts by weight: 1.8 parts of Jasmine japonica, 2 parts of mugwort leaves, 1.2 parts of dandelion, 1 part of safflower, 2.5 parts of gardenia, and 2.5 parts of aloe.

Further, the auxiliary materials include the following raw materials in parts by weight: 0.75 parts of camphor, 0.75 parts of menthol, 0.75 parts of borneol, and 0.25 parts of polyvinyl alcohol.

Further, the postoperative dressing plant concentrated film also includes ingredients, and the ingredients include the following raw materials in parts by weight: 0.4-0.9 parts of shea butter, 0.6-1.2 parts of melaleuca oil, 0.3-0.8 parts of rapeseed polypeptide 0.2-0.4 part of seaweed active peptide, 0.03-0.1 part of p-anisic acid, the molecular weight of the seaweed active peptide is 5000-1000Da.

Further, the mass-to-volume kg/L ratio of the auxiliary material, the preservative, and the extract plant concentrate is 20-30:8-15:100.

Further, a method for preparing a disposable postoperative dressing plant concentrated film, comprising the following steps:

S1. Extraction plant concentrate: wash the above-mentioned mountain silver flower, mugwort leaf, dandelion, safflower, gardenia, aloe, remove impurities, dry, chop, dry, and crush to 100-120 mesh after drying Sieve into mixed powder, add deionized water, stir evenly, the mass volume ratio of mixed powder and deionized water g/mL is 1-3:80, put it in an ultrasonic extractor, at a power of 300-500W, a temperature of 60 Extract at -80°C for 5-7 minutes, centrifuge, take out the supernatant to obtain the first concentrated solution, add deionized water to the filter residue, the mass volume g/mL of the filter residue and deionized water is 1-3:80, repeat The above-mentioned ultrasonic extraction method obtains the second concentrated solution;

S2. Preparation of liquid I: Take the above-mentioned first concentrated solution and the second concentrated solution according to the volume ratio of 6:3-5 and mix evenly, add auxiliary materials, heat to 50-70°C and stir for 10-30min, the stirring rate is 400-600rpm, Get liquid I;

S3. Preparation of liquid II: Slowly add the ingredients into liquid I, stir until evenly mixed, then homogenize at a high speed at 40-80°C to obtain liquid II.

S4. Use a coating machine to coat the above-mentioned liquid I or liquid II on the surface layer of the non-woven fabric, the thickness of the coating layer is 0.1-0.3mm, and then solidify it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrate membrane.

Further, the high-speed homogenization condition of S3 is 8000-12000rpm, and the homogenization time is 10-20min.

Further, the disposable postoperative dressing plant concentrated film is applied to non-chronic postoperative wound care.

Further, non-chronic postoperative wound care is suturing the incision and covering the wound after surgery.

Compared with prior art, the beneficial effect of the present invention is:

The post-operative dressing plant concentrated film of the present invention adopts the synergistic effect of extracting plant concentrate, auxiliary materials and materials, and the joint antibacterial effect is significantly enhanced, with little irritation and no toxic side effects, which can promote the rapid healing of wounds and restore the skin barrier function. At the same time, it can avoid the formation of serious scars on the wound surface; extracting the raw materials in the plant concentrate according to a specific ratio is beneficial to improve the repairing ability of the concentrated film, and at the same time adding ingredients can help maintain normal immunity and can better assist the plant concentrate Induce the immunity of the skin system and promote cell proliferation, accelerate cell repair, place tissue adhesion, and avoid secondary damage to the new skin. Among them, shea butter and melaleuca oil form a stable hydrophobic structure, which is beneficial to reduce blood vessels on the wound. The abnormal permeability of the skin can relieve the edema of the wound. Rapeseed polypeptide and seaweed active peptide can regulate the synthesis of collagen in the wound, which is helpful for wound healing. The active ingredients precipitated from the concentrated film can destroy the scar cell wall, and the active ingredients inhibit absorption. Remove scar hyperplasia cells and fibrous connective tissue, so as to achieve the purpose of radical scarring, make scar wounds comparable to normal skin, and scar cells no longer continue to proliferate.

Detailed ways

In order to better understand the technical content of the present invention, specific examples are provided below to further illustrate the present invention.

The experimental methods used in the examples of the present invention are conventional methods unless otherwise specified.

The materials and reagents used in the examples of the present invention can be obtained from commercial sources unless otherwise specified.

Example 1

A kind of disposable postoperative dressing plant concentrated film: including extraction plant concentrate and auxiliary materials, said extraction plant concentrate includes the following weight raw materials per 10L: mountain silver flower 1.8kg, Artemisia argyi 2kg, dandelion 1.2kg, safflower 1kg , gardenia 2.5kg, aloe 2.5kg, and the balance is deionized water; the auxiliary materials include the following weight raw materials: camphor 0.75kg, menthol 0.75kg, borneol 0.75kg, polyvinyl alcohol 0.25kg;

The preparation method of above-mentioned concentrated film comprises the following steps:

S1. Extraction plant concentrate: wash the above-mentioned mountain silver flower, mugwort leaf, dandelion, safflower, gardenia, aloe, remove impurities, dry, chop, dry, and crush to a 120-mesh sieve after drying. Mix the powder, add deionized water, stir evenly, the mass volume ratio of the mixed powder and deionized water g/mL is 2:80, put it in an ultrasonic extractor, extract at a power of 400W and a temperature of 70°C for 6min, and centrifuge Separate, take out the supernatant to obtain the first concentrated solution, add deionized water to the filter residue, the mass volume g/mL of the filter residue and deionized water is 2:80, repeat the above ultrasonic extraction method to obtain the second concentrated solution;

S2. Preparation of liquid I: Take 6000 mL of the above-mentioned first concentrated solution and 4000 mL of the second concentrated liquid and mix evenly, add 2.5 kg of auxiliary materials, heat to 60° C. and stir for 20 minutes at a stirring speed of 500 rpm to obtain liquid I;

S3. Use a coating machine to coat the above liquid I on the surface layer of the non-woven fabric, the thickness of the coating layer is 0.1-0.3 mm, and then solidify it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

Example 2

A disposable postoperative dressing plant concentrated film: including extract plant concentrate, auxiliary materials and materials, the extract plant concentrate contains the following weight raw materials per 10L: 1kg of Yam Flos Japonica, 1kg of Artemisia argyi, 1kg of Dandelion, safflower 0.5kg, gardenia 2kg, aloe 2kg; the auxiliary materials include the following raw materials by weight: camphor 0.5kg, menthol 0.5kg, borneol 0.5kg, polyvinyl alcohol 0.2kg, and the materials include the following raw materials by weight: shea butter Oil 0.4kg, Melaleuca oil 0.6kg, rapeseed polypeptide 0.3kg, seaweed active peptide 0.2kg, p-anisic acid 0.03kg, the molecular weight of the seaweed active peptide is 5000-1000Da.

Example 3

A kind of one-time postoperative dressing plant concentrated film: including leaching plant concentrate, auxiliary materials and materials, said leaching plant concentrate includes the following weight raw materials per 10L: mountain silver flower 2kg, Artemisia argyi 3kg, dandelion 1.5kg, red Flower 1.5kg, gardenia 3kg, aloe 3kg; the auxiliary materials include the following weight raw materials: camphor 0.8kg, menthol 0.8kg, borneol 0.8kg, polyvinyl alcohol 0.3kg, and the described materials include the following weight raw materials: shea wood 0.9kg of fruit oil, 1.2kg of melaleuca oil, 0.8kg of rapeseed polypeptide, 0.4kg of seaweed active peptide, and 0.1kg of p-anisic acid. The molecular weight of the seaweed active peptide is 5000-1000Da.

Example 4

A kind of one-time postoperative dressing plant concentrated film: including leaching plant concentrate, auxiliary materials and materials, said leaching plant concentrate includes the following weight raw materials per 10 liters: 1.8kg of mountain silver flower, 2kg of Artemisia argyi, 1.2kg of dandelion , safflower 1kg, jasmine jasmine 2.5kg, aloe 2.5kg, described auxiliary material comprises following weight raw material: camphor 0.75kg, menthol 0.75kg, borneol 0.75kg, polyvinyl alcohol 0.25kg, described making material comprises following weight raw material : Shea butter 0.6kg, melaleuca oil 0.9kg, rapeseed polypeptide 0.5kg, seaweed active peptide 0.3kg, p-anisic acid 0.06kg, the molecular weight of the seaweed active peptide is 5000-1000Da;

Above-mentioned embodiment 2-4 adopts following preparation method:

S1. Extraction plant concentrate: wash the above-mentioned mountain silver flower, mugwort leaves, dandelion, safflower, gardenia, aloe, remove impurities, dry, chop, dry, and crush to a 110-mesh sieve after drying. Mix the powder, add deionized water, stir evenly, the mass volume ratio of the mixed powder and deionized water g/mL is 2:80, put it in an ultrasonic extractor, extract at a power of 400W and a temperature of 70°C for 6min, and centrifuge Separate, take out the supernatant to obtain the first concentrated solution, add deionized water to the filter residue, the mass volume g/mL of the filter residue and deionized water is 2:80, repeat the above ultrasonic extraction method to obtain the second concentrated solution;

S2. Preparation of liquid I: Take the above-mentioned first concentrated liquid and the second concentrated liquid at a volume ratio of 6:4 and mix evenly, add auxiliary materials, heat to 60° C. and stir for 20 minutes at a stirring speed of 500 rpm to obtain liquid I;

S3. Preparation of liquid II: Slowly add the ingredients into liquid I, stir until evenly mixed, then homogenize at a high speed at 60°C, the speed of high-speed homogenization is 10,000 rpm, and the homogenization time is 15 minutes, to obtain liquid II.

S4. Use a coating machine to coat the above-mentioned liquid II on the surface layer of the non-woven fabric, the thickness of the coating layer is 0.2 mm, and then solidify it in a clean room at room temperature to obtain a disposable postoperative dressing plant concentrated film.

Example 5

A kind of one-time postoperative dressing plant concentrated film: including leaching plant concentrate, auxiliary materials and materials, said leaching plant concentrate includes the following weight raw materials per 10 liters: 1.8kg of mountain silver flower, 2kg of Artemisia argyi, 1.2kg of dandelion , safflower 1kg, jasmine jasmine 2.5kg, aloe 2.5kg, described auxiliary material comprises following weight raw material: camphor 0.75kg, menthol 0.75kg, borneol 0.75kg, polyvinyl alcohol 0.25kg, described making material comprises following weight raw material : Shea butter 0.6kg, melaleuca oil 0.9kg, rapeseed polypeptide 0.5kg, seaweed active peptide 0.3kg, p-anisic acid 0.06kg, the molecular weight of the seaweed active peptide is 5000-1000Da;

Above-mentioned concentrated film adopts following preparation method:

S1. Extraction plant concentrate: wash the above-mentioned mountain silver flower, mugwort leaf, dandelion, safflower, gardenia, aloe, remove impurities, dry, chop, dry, and crush to 100 mesh sieve after drying. Mix the powder, add deionized water, stir evenly, the mass volume ratio of the mixed powder and deionized water g/mL is 1:80, put it in an ultrasonic extractor, extract at a power of 300W and a temperature of 60°C for 5min, and centrifuge Separating, taking out the supernatant to obtain the first concentrated solution, adding deionized water to the filter residue, the mass volume g/mL of the filter residue and deionized water is 1:80, repeating the above ultrasonic extraction method to obtain the second concentrated solution;

S2. Preparation of liquid I: Take the above-mentioned first concentrated liquid and the second concentrated liquid at a volume ratio of 6:3 and mix evenly, add auxiliary materials, heat to 50-70° C. and stir for 10 min at a stirring speed of 400 rpm to obtain liquid I;

S3. Preparation of liquid II: Slowly add the ingredients into liquid I, stir while adding until evenly mixed, then homogenize at a high speed at 40°C, the speed of high-speed homogenization is 8000rpm, and the homogenization time is 10min, to obtain liquid II.

S4. Use a coating machine to coat the above-mentioned liquid I or liquid II on the surface layer of the non-woven fabric, the thickness of the coating layer is 0.1-0.3mm, and then solidify it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrate membrane.

Example 6

A kind of one-time postoperative dressing plant concentrated film: including leaching plant concentrate, auxiliary materials and materials, said leaching plant concentrate includes the following weight raw materials per 10 liters: 1.8kg of mountain silver flower, 2kg of Artemisia argyi, 1.2kg of dandelion , safflower 1kg, jasmine jasmine 2.5kg, aloe 2.5kg, described auxiliary material comprises following weight raw material: camphor 0.75kg, menthol 0.75kg, borneol 0.75kg, polyvinyl alcohol 0.25kg, described making material comprises following weight raw material : Shea butter 0.6kg, melaleuca oil 0.9kg, rapeseed polypeptide 0.5kg, seaweed active peptide 0.3kg, p-anisic acid 0.06kg, the molecular weight of the seaweed active peptide is 5000-1000Da;

Above-mentioned concentrated film adopts following preparation method:

S1. Extraction plant concentrate: wash the above-mentioned mountain silver flower, mugwort leaf, dandelion, safflower, gardenia, aloe, remove impurities, dry, chop, dry, and crush to a 120-mesh sieve after drying. Mix the powder, add deionized water, stir evenly, the mass volume ratio of the mixed powder and deionized water g/mL is 3:80, place in an ultrasonic extractor, extract at a power of 500W and a temperature of 80°C for 7min, centrifuge Separate, take out the supernatant to obtain the first concentrated solution, add deionized water to the filter residue, the mass volume g/mL of the filter residue and deionized water is 3:80, repeat the above ultrasonic extraction method to obtain the second concentrated solution;

S2. Preparation of liquid I: Take the above-mentioned first concentrated liquid and the second concentrated liquid at a volume ratio of 6:5 and mix evenly, add auxiliary materials, heat to 70° C. and stir for 30 minutes at a stirring rate of 600 rpm to obtain liquid I;

S3. Preparation of liquid II: Slowly add the ingredients into liquid I, stir while adding until evenly mixed, then homogenize at a high speed at 80°C, the speed of high-speed homogenization is 12000 rpm, and the homogenization time is 20 minutes, to obtain liquid II.

S4. Use a coating machine to coat the above-mentioned liquid I or liquid II on the surface layer of the non-woven fabric, the thickness of the coating layer is 0.1-0.3mm, and then solidify it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrate membrane.

Comparative example 1

The difference between this comparative example and Example 1 is that each 10L of the extracted plant concentrate includes the following weight raw materials: 3 kg of Lily japonicus, 1 kg of Artemisia argyi, 2 kg of dandelion, 0.1 kg of safflower, 1 kg of Jasmine jasminoides, and 5 kg of aloe.

Specifically, it is a kind of one-time postoperative dressing plant concentrated film: including extract plant concentrate and auxiliary materials, the extract plant concentrate contains the following weight raw materials per 10L: mountain silver flower 3kg, mugwort leaf 1kg, dandelion 2kg, safflower 0.1 kg, gardenia jasmine 1kg, aloe 5kg, and the balance is deionized water; the auxiliary materials include the following raw materials by weight: 0.75kg camphor, 0.75kg menthol, 0.75kg borneol, 0.25kg polyvinyl alcohol;

The preparation method of above-mentioned concentrated film comprises the following steps:

S1. Extraction plant concentrate: wash the above-mentioned mountain silver flower, mugwort leaf, dandelion, safflower, gardenia, aloe, remove impurities, dry, chop, dry, and crush to a 120-mesh sieve after drying. Mix the powder, add deionized water, stir evenly, the mass volume ratio of the mixed powder and deionized water g/mL is 2:80, put it in an ultrasonic extractor, extract at a power of 400W and a temperature of 70°C for 6min, and centrifuge Separate, take out the supernatant to obtain the first concentrated solution, add deionized water to the filter residue, the mass volume g/mL of the filter residue and deionized water is 2:80, repeat the above ultrasonic extraction method to obtain the second concentrated solution;

S2. Preparation of liquid I: Take 6000 mL of the above-mentioned first concentrated solution and 4000 mL of the second concentrated liquid and mix evenly, add 2.5 kg of auxiliary materials, heat to 60° C. and stir for 20 minutes at a stirring speed of 500 rpm to obtain liquid I;

S3. Use a coating machine to coat the above liquid I on the surface layer of the non-woven fabric, the thickness of the coating layer is 0.1-0.3 mm, and then solidify it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

Comparative example 2

The difference between this comparative example and Example 4 is that the ingredients include the following raw materials by weight: 0.1kg of shea butter, 0.2kg of melaleuca oil, 0.1kg of rapeseed polypeptide, 0.5kg of seaweed active peptide, p-anisic acid 0.01kg;

Specifically, it is a kind of one-time postoperative dressing plant concentrated film: including extract plant concentrate, auxiliary materials and materials, and the extract plant concentrate contains the following weight raw materials per 10 liters: 1.8kg of mountain silver flower, 2kg of Artemisia argyi, dandelion 1.2kg, safflower 1kg, gardenia jasmine 2.5kg, aloe 2.5kg, described auxiliary material comprises following weight raw material: camphor 0.75kg, menthol 0.75kg, borneol 0.75kg, polyvinyl alcohol 0.25kg, described auxiliary material comprises following Weight raw materials: 0.1kg of shea butter, 0.2kg of melaleuca oil, 0.1kg of rapeseed polypeptide, 0.5kg of seaweed active peptide, 0.01kg of p-anisic acid, the molecular weight of the seaweed active peptide is 5000-1000Da;

Above-mentioned concentrated film adopts following preparation method:

S1. Extraction plant concentrate: wash the above-mentioned mountain silver flower, mugwort leaves, dandelion, safflower, gardenia, aloe, remove impurities, dry, chop, dry, and crush to a 110-mesh sieve after drying. Mix the powder, add deionized water, stir evenly, the mass volume ratio of the mixed powder and deionized water g/mL is 2:80, put it in an ultrasonic extractor, extract at a power of 400W and a temperature of 70°C for 6min, and centrifuge Separate, take out the supernatant to obtain the first concentrated solution, add deionized water to the filter residue, the mass volume g/mL of the filter residue and deionized water is 2:80, repeat the above ultrasonic extraction method to obtain the second concentrated solution;

S2. Preparation of liquid I: Take the above-mentioned first concentrated liquid and the second concentrated liquid at a volume ratio of 6:4 and mix evenly, add auxiliary materials, heat to 60° C. and stir for 20 minutes at a stirring speed of 500 rpm to obtain liquid I;

S3. Preparation of liquid II: Slowly add the ingredients into liquid I, stir until evenly mixed, then homogenize at a high speed at 60°C, the speed of high-speed homogenization is 10,000 rpm, and the homogenization time is 15 minutes, to obtain liquid II.

S4. Use a coating machine to coat the above-mentioned liquid II on the surface layer of the non-woven fabric, the thickness of the coating layer is 0.2 mm, and then solidify it in a clean room at room temperature to obtain a disposable postoperative dressing plant concentrated film.

Comparative example 3

The difference between this comparative example and Example 4 is that the shea butter and the melaleuca oil are replaced by equal amounts of palm oil and rapeseed oil in the described materials.

Specifically, it is a kind of one-time postoperative dressing plant concentrated film: including extract plant concentrate, auxiliary materials and materials, and the extract plant concentrate contains the following weight raw materials per 10 liters: 1.8kg of mountain silver flower, 2kg of Artemisia argyi, dandelion 1.2kg, safflower 1kg, gardenia jasmine 2.5kg, aloe 2.5kg, described auxiliary material comprises following weight raw material: camphor 0.75kg, menthol 0.75kg, borneol 0.75kg, polyvinyl alcohol 0.25kg, described auxiliary material comprises following Weight raw materials: palm oil 0.6kg, rapeseed oil 0.9kg, rapeseed polypeptide 0.5kg, seaweed active peptide 0.3kg, p-anisic acid 0.06kg, the molecular weight of the seaweed active peptide is 5000-1000Da;

Above-mentioned concentrated film adopts following preparation method:

S1. Extraction plant concentrate: wash the above-mentioned mountain silver flower, mugwort leaves, dandelion, safflower, gardenia, aloe, remove impurities, dry, chop, dry, and crush to a 110-mesh sieve after drying. Mix the powder, add deionized water, stir evenly, the mass volume ratio of the mixed powder and deionized water g/mL is 2:80, put it in an ultrasonic extractor, extract at a power of 400W and a temperature of 70°C for 6min, and centrifuge Separate, take out the supernatant to obtain the first concentrated solution, add deionized water to the filter residue, the mass volume g/mL of the filter residue and deionized water is 2:80, repeat the above ultrasonic extraction method to obtain the second concentrated solution;

S2. Preparation of liquid I: Take the above-mentioned first concentrated liquid and the second concentrated liquid at a volume ratio of 6:4 and mix evenly, add auxiliary materials, heat to 60° C. and stir for 20 minutes at a stirring speed of 500 rpm to obtain liquid I;

S3. Preparation of liquid II: Slowly add the ingredients into liquid I, stir until evenly mixed, then homogenize at a high speed at 60°C, the speed of high-speed homogenization is 10,000 rpm, and the homogenization time is 15 minutes, to obtain liquid II.

S4. Use a coating machine to coat the above-mentioned liquid II on the surface layer of the non-woven fabric, the thickness of the coating layer is 0.2 mm, and then solidify it in a clean room at room temperature to obtain a disposable postoperative dressing plant concentrated film.

Comparative example 4

The difference between this comparative example and Example 4 is that the said feed does not contain rapeseed polypeptide.

Comparative example 5

The difference between this comparative example and Example 4 is that the active ingredient does not contain seaweed peptides.

1. Safety experiment

The disposable postoperative dressing plant concentrate films of Examples 1-6 and Comparative Examples 1-5 were respectively subjected to animal skin irritation test, skin sensitization test, and in vitro cytotoxicity test, and the results showed that they were safe and non-toxic.

2. Antibacterial performance test

According to the 2020 version of "Chinese Pharmacopoeia": Antibacterial Effectiveness Inspection Method I liquid of embodiment 1 and II liquid of embodiment 2-6 are to Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Pseudomonas aeruginosa Bacteriostasis effect, the results are as follows in Table 1:

As can be seen from the above table, the dressing plant concentrated film prepared by the present invention is more than 95% bacteriostatic to Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Pseudomonas aeruginosa, wherein the bacteriostatic effect of Example 4 better.

3. Wound repair experiment

1. Experimental animals and grouping: Select 60 SD rats, half male and half male, and randomly divide them into 6 groups, corresponding to Example 4 and Comparative Examples 1-5 respectively, with 10 rats in each group.

2. Experimental method: After the rat was anesthetized with 4% chloral hydrate, the hair on the back of the rat was removed. The depilated area was 5×4cm. ^20cm skin superficial II level damage, respectively sticking dressing plant concentrated film of the present invention on the wound site, administration 2 times a day, once in the morning and evening, counting the healing time and 7-day average healing rate respectively,

Healing rate% = healing area/wound area × 100

The results are shown in Table 2 below:

As can be seen from Table 2, the wound healing rate of rats in Example 4 is higher than that of Comparative Examples 1-5, and the healing rate is higher than that of Comparative Examples 1-5, and the dressing plant concentrated film prepared by the present invention obviously shortens the wound healing time , the wound repair effect is good, it reduces the secretion of wound exudate, promotes the reconstruction of skin tissue, and accelerates the repair of damaged cells. The repairing ability of the membrane, while adding ingredients can help maintain normal immunity. The plant concentrate, accessories, and ingredients work together to promote the rapid healing of wounds and promote the restoration of skin barrier function;

Compared with Comparative Example 2, the reasonable raw materials screened by the scientific ratio can better assist the plant concentrate to induce the immunity of the skin system and promote cell proliferation, accelerate the repair of cells, prevent tissue adhesion, and avoid secondary skin regeneration. damage;

Compared with Comparative Example 3, shea butter and melaleuca oil form a stable hydrophobic structure, which is beneficial to reduce the abnormal permeability of blood vessels in the wound and relieve the edema of the wound.

Compared with Comparative Examples 4 and 5, the use of rapeseed polypeptide and seaweed active peptide can regulate the synthesis of wound collagen and help wound healing.

4. Scar removal performance test

Select 40 patients with hypertrophic scars in the sutured incision after surgical operation, including 22 males and 18 females, aged 10-50 years old, randomly divided into 2 groups, 20 people in each group, one group of experimental group is embodiment 4 The II solution of the drug, and a group of control groups were commercially available Sefcon dressings, which were applied for 5 hours a day and treated for 30 days.

Curative effect standard:

The curative effect results are as follows in Table 3:

group Number of cases get well efficient invalid Efficient/% Example 4 20 18 20 0 100% commercially available 20 12 15 5 75%

As can be seen from Table 3, compared with the commercially available, the postoperative dressing plant concentrated film of the present invention has a better healing effect on the sutured incision wound after the surgical operation, while avoiding the formation of serious scars at the wounds, and the scars of the wounds without itching, Burning heat, pain, scar hyperemia subsided, the color gradually became the same as the skin color, the capillaries on the scar surface disappeared, the scar became soft, the thickness was reduced to be equivalent to that of normal skin, and the scar cells no longer continued to proliferate.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the scope of the present invention. within the scope of protection.

Claims (9)

1. A disposable postoperative dressing plant concentrating film which is characterized in that: the plant extract comprises extracted plant concentrated solution and auxiliary materials, wherein the extracted plant concentrated solution comprises the following raw materials in parts by weight: 1-2 parts of lonicera japonica, 1-3 parts of mugwort leaf, 1-1.5 parts of dandelion, 0.5-1.5 parts of safflower, 2-3 parts of gardenia and 2-3 parts of aloe; the auxiliary materials comprise the following raw materials in parts by weight: 0.5 to 0.8 part of camphor, 0.5 to 0.8 part of menthol, 0.5 to 0.8 part of borneol and 0.2 to 0.3 part of polyvinyl alcohol.

2. A disposable post-operative dressing plant concentrating film as claimed in claim 1, wherein: the extracted plant concentrated solution comprises the following raw materials in parts by weight: 1.8 parts of honeysuckle, 2 parts of mugwort leaf, 1.2 parts of dandelion, 1 part of safflower, 2.5 parts of gardenia and 2.5 parts of aloe.

3. A disposable post-operative dressing plant concentrating film as claimed in claim 1, wherein: the auxiliary materials comprise the following raw materials in parts by weight: 0.75 part of camphor, 0.75 part of menthol, 0.75 part of borneol and 0.25 part of polyvinyl alcohol.

4. A disposable post-operative dressing plant concentrating film as claimed in claim 1, wherein: the postoperative dressing plant concentration membrane also comprises a material, wherein the material comprises the following raw materials in parts by weight: 0.4-0.9 part of shea butter, 0.6-1.2 parts of cajeput oil, 0.3-0.8 part of rapeseed polypeptide, 0.2-0.4 part of seaweed active peptide and 0.03-0.1 part of p-anisic acid, wherein the molecular weight of the seaweed active peptide is 5000-1000Da.

5. A disposable post-operative dressing plant concentrating film as claimed in claim 4, wherein: the mass volume kg/L ratio of the auxiliary materials to the plant concentrate is 20-30:8-15:100.

6. A method for preparing a disposable post-operative dressing plant concentrating film as claimed in claim 1, wherein: the method comprises the following steps:

s1, leaching plant concentrated solution: washing the lonicera japonica, the mugwort leaves, the dandelion, the safflower, the gardenia and the aloe, removing impurities, airing, cutting, drying, crushing to 100-120 meshes, sieving to obtain mixed powder, adding deionized water, uniformly stirring, extracting the mixed powder and the deionized water at a mass volume ratio g/mL of 1-3:80 in an ultrasonic extractor at a power of 300-500W and a temperature of 60-80 ℃ for 5-7min, centrifugally separating, taking out supernatant to obtain a first concentrated solution, adding deionized water into filter residues, and repeating the ultrasonic extraction method to obtain a second concentrated solution, wherein the mass volume g/mL of the filter residues and the deionized water is 1-3:80;

s2, preparing a solution I: mixing the first concentrated solution and the second concentrated solution uniformly according to the volume ratio of 6:3-5, adding auxiliary materials, heating to 50-70 ℃ and stirring for 10-30min at the stirring speed of 400-600rpm to obtain solution I;

s3, preparing a II solution: slowly adding the materials into the solution I, stirring while adding until the materials are uniformly mixed, and homogenizing at a high speed at 40-80 ℃ to obtain the solution II.

S4, coating the liquid I or the liquid II on a non-woven fabric surface layer by using a coating machine, wherein the thickness of the coating layer is 0.1-0.3mm, and then curing the coating layer at normal temperature in a clean room to obtain the disposable postoperative dressing plant concentrated film.

7. The method for preparing the disposable postoperative dressing plant concentrating film according to claim 6, wherein the method comprises the following steps: the high-speed homogenizing condition speed of the S3 is 8000-12000rpm, and the homogenizing time is 10-20min.

8. A disposable post-operative dressing plant concentrating film according to any one of claims 1 to 5 for use in non-chronic post-operative wound care.

9. The non-chronic post-operative wound care of claim 8 is a post-surgical suture incision and wound cover.