CN116077355A - Fluoride anti-caries composition, fluoride anti-caries agent and its application in orthodontics - Google Patents

Abstract

The invention provides a fluorine anticaries composition, a fluorine anticaries agent and application thereof in correcting teeth. The fluorine anticarious composition comprises, by weight, 1-5 parts of peroxide, 0.01-0.03 part of fluoride, 0.3-3 parts of foaming agent and 90-98 parts of water, wherein the peroxide is calculated by hydrogen peroxide; wherein the hydrogen peroxide is directly provided by peroxide, or the hydrogen peroxide generated by the peroxide released after being dissolved in water, and the pH value of the fluorine anticaries composition is 5-7. The addition of peroxide only requires the addition of a relatively low amount of fluoride and by the synergistic effect of the two, bacteria causing caries and off-flavor can be inhibited from the source, the teeth can be contacted with the fluoride and peroxide in the above safe doses for a long time, i.e. the person wearing the dental mouthpiece can use the dental mouthpiece within 24 hours per day to strengthen the hardness of the dental enamel, prevent caries and keep the dental mouthpiece clean.

Description

Fluoride anti-caries composition, fluoride anti-caries agent and its application in orthodontics

technical field

The invention relates to the technical field of caries prevention, in particular to a fluorine caries prevention composition, a fluorine caries prevention agent and their application in tooth correction.

Background technique

The application of fluoride for anti-caries treatment is a common clinical treatment. The common fluorides mainly include sodium fluoride and sodium monofluorophosphate. The common fluoride concentrations are 12300ppm, 9600ppm, and 6000ppm. Usually, a pressurized gas tank is used to fill a certain pressure of isobutane and other gases, mixed with essence, foaming agent, Moisturizing agent etc. combination fluoride anti-caries composition. When in use, a certain amount of fluoride foam should be extruded from the dental tray, and then spit out after occlusal for a few minutes to achieve the purpose of caries prevention. It is mainly used in the anti-caries treatment of people of all ages. Products are usually non-water based foaming systems.

The existing fluoride foam is a high-concentration formula, and if it is used for a long time or excessively, there will be a very high probability of fluorosis and dental fluorosis. The single effect of existing fluorinated foam can only be used for preventing dental caries. Use pressurized gas cylinders, which are inconvenient to carry and have the risk of explosion.

Contents of the invention

The main purpose of the present invention is to provide a fluoride anti-caries composition, a fluorine anti-caries agent and its application in orthodontics, so as to solve the problem of extremely high fluorosis and fluorosis when the fluoride foam in the prior art is continuously used. The problem of tooth occurrence probability.

In order to achieve the above object, according to one aspect of the present invention, a fluoride anti-caries composition is provided, in parts by weight, the fluoride anti-caries composition comprises: in terms of hydrogen peroxide, 1 to 5 parts of peroxide , 0.01 to 0.03 parts of fluoride, 0.3 to 3 parts of foaming agent, and 90 to 98 parts of water; among them, hydrogen peroxide is directly provided by peroxide, or the peroxide produced by releasing peroxide after dissolving in water The pH value of the hydrogen and fluorine anti-caries composition is 5-7.

Further, the above-mentioned peroxide is selected from any one or more of hydrogen peroxide, sodium percarbonate, carbamide peroxide, sodium perborate, preferably the peroxide is selected from hydrogen peroxide and sodium percarbonate, further, Preferably, the mass ratio of hydrogen peroxide to sodium percarbonate is 1:10-10:1, preferably 1:10-2:1.

Further, the above-mentioned fluoride anti-caries composition also includes fulvic acid, preferably the mass ratio of fulvic acid to hydrogen peroxide is 1:20-1:10.

Further, the foaming agent is selected from any one or more of sodium lauryl sulfate, sodium lauryl sulfate, polysorbate 20, sodium lauryl sarcosinate, and betaine.

Further, the above-mentioned fluoride is selected from any one or more of sodium fluoride, potassium fluoride, and sodium monofluorophosphate, preferably sodium fluoride.

Further, the above-mentioned fluoride anti-caries composition also includes 0.1 to 2 parts of a stabilizer, preferably the stabilizer is selected from EDTA2Na, Poloxamer 407, Poloxamer 408, citric acid, glycerin, propylene glycol, sodium citrate, benzene Any one or more of sodium formate.

Further, the above-mentioned fluoride anti-caries composition also includes 0.1-2 parts of a flavoring agent, and the flavoring agent includes essence and/or sweetener, preferably the essence is a fruit-flavored essence, further, it is preferably a mint-flavored essence; preferably The sweetener is selected from any one or more of xylitol, erythritol, sucralose, sodium saccharin, further, preferably xylitol and sucralose.

According to another aspect of the present invention, a fluoride anti-caries agent is provided, which is prepared by mixing the aforementioned fluoride anti-caries composition.

According to another aspect of the present invention, there is provided a kind of application of the above-mentioned fluoride anti-caries agent in orthodontics. After pumping the fluoride anti-caries agent into invisible braces or invisible retainers, it is worn and used. The fluoride anti-caries agent can be used 24 hours a day. Continuously used in the oral cavity of the human body, the fluoride anti-caries agent is preferably pumped into the invisible braces or the invisible retainer by squeezing the foaming bottle.

Applying the technical scheme of the present invention, the addition of peroxide in the fluoride anti-caries composition can kill most of the bacteria in the inner environment of the braces and on the surface of the teeth, so that only a relatively low amount of fluoride needs to be added and through two The synergistic effect of the two can contain the bacteria that cause dental caries and odor from the source, and will not destroy the flora balance of the overall oral environment. The above-mentioned peroxides are non-toxic ingredients, which can be decomposed into oxygen and water. Because of their certain permeability, using peroxides alone to whiten teeth may cause reversible pulpitis. When used, it reduces dentin demineralization, thereby reducing the penetration of peroxide products into the dental pulp. Therefore, the teeth can be in contact with the above safe dose of fluoride and peroxide for a long time, that is, the wearer of braces can use it within 24 hours a day to strengthen the hardness of tooth enamel, prevent dental caries, and keep the braces clean. In addition, peroxides can additionally break down exogenous pigments, reduce the probability of deposits, and reduce the chance of yellowing of teeth during braces. Peroxides can additionally whiten teeth and reduce the chance of yellowing of teeth that can occur while wearing braces.

Keeping the pH value of the fluoride anti-caries composition at 5-7 is conducive to maintaining its mildness, thus making it more suitable for long-term use.

Detailed ways

It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The present invention will be described in detail below in conjunction with examples.

As analyzed in the background technology of this application, the fluorinated foam in the prior art has a very high probability of occurrence of fluorosis and dental fluorosis when used continuously. In order to solve this problem, this application provides a fluoride anti-caries combination substances, fluoride anti-caries agents and their application in orthodontics.

In a typical implementation of the present application, a fluoride anti-caries composition is provided. In parts by weight, the fluoride anti-caries composition includes: in terms of hydrogen peroxide, 1 to 5 parts of peroxide , 0.01 to 0.03 parts of fluoride, 0.3 to 3 parts of foaming agent, and 90 to 98 parts of water; among them, hydrogen peroxide is directly provided by peroxide, or the peroxide produced by releasing peroxide after dissolving in water The pH value of the hydrogen and fluorine anti-caries composition is 5-7.

The addition of peroxide in the fluoride anti-caries composition can kill most of the bacteria in the inner environment of the braces and on the surface of the teeth, so that only a relatively low amount of fluoride needs to be added and through the synergistic effect of the two, the Contain the bacteria that cause dental caries and bad smell at the source, and will not disrupt the flora balance of the overall oral environment. The above-mentioned peroxides are non-toxic ingredients, which can be decomposed into oxygen and water. Because of their certain permeability, using peroxides alone to whiten teeth may cause reversible pulpitis. When used, it reduces dentin demineralization, thereby reducing the penetration of peroxide products into the dental pulp. Therefore, the teeth can be in contact with the above safe dose of fluoride and peroxide for a long time, that is, the wearer of braces can use it within 24 hours a day to strengthen the hardness of tooth enamel, prevent dental caries, and keep the braces clean. In addition, peroxides can additionally break down exogenous pigments, reduce the probability of deposits, and reduce the chance of yellowing of teeth during braces. Peroxides can additionally whiten teeth and reduce the chance of yellowing of teeth that can occur while wearing braces.

Keeping the pH value of the fluoride anti-caries composition at 5-7 is conducive to maintaining its mildness, thus making it more suitable for long-term use.

In one embodiment of the present application, the above-mentioned peroxide is selected from any one or more of hydrogen peroxide, sodium percarbonate, carbamide peroxide, sodium perborate, preferably the peroxide is selected from hydrogen peroxide and Sodium percarbonate, further preferably, the mass ratio of hydrogen peroxide and sodium percarbonate is 1:10 to 10:1, preferably 1:10 to 2:1.

The above peroxides are non-toxic components. Hydrogen peroxide itself can directly provide the hydrogen peroxide components required by the fluoride anti-caries composition. Sodium percarbonate, carbamide peroxide, and sodium perborate slowly release hydrogen peroxide by dissolving in water . The mass ratio of preferred hydrogen peroxide and sodium percarbonate is on the basis of excellent bactericidal and bleaching effects, and the sodium carbonate component in sodium percarbonate can produce the effect of foaming agent, thereby helping to prepare the above water-based composition Formed into a foamed product for use inside braces or invisible retainers.

In one embodiment of the present application, the above-mentioned fluoride anti-caries composition further includes fulvic acid, preferably the mass ratio of fulvic acid to hydrogen peroxide is 1:20-1:10.

Fulvic acid itself is a substance that can repair cell peroxidation, and can reduce the sensitivity of some groups to long-term use of hydrogen peroxide after peroxides, especially hydrogen peroxide, come into contact with the gums. Moreover, fulvic acid can reduce the biofilm load of mucus on the tooth surface, penetrate the interior of the biofilm and reduce the bacterial load, and through the synergistic effect with hydrogen peroxide, it can kill free oral bacteria and bacteria inside the biofilm. In addition, fulvic acid has the effect of regulating cellular immune activity, and can reduce the content of inflammatory mediators such as IL-8 caused by biofilm stimulation. However, it is additionally found that in some cases, fulvic acid has a very slight risk of causing tooth staining, and the preferred mass ratio of fulvic acid to hydrogen peroxide is more conducive to the effect of the two, and through the interaction between the two The synergistic cooperation achieves the optimal bactericidal and anti-allergic effects, and prevents the occurrence of tooth staining caused by fulvic acid.

The above fulvic acid is extracted from carbohydrates through a special process, referred to as CHD-FA. For details, please refer to the existing related extraction technology, such as the literature with DOI number 10.1186/1472-6831-13-47, and will not repeat it here .

In one embodiment of the present application, the above-mentioned foaming agent is selected from any one of sodium lauryl sulfate, sodium lauryl sulfate, polysorbate 20, sodium lauryl sarcosinate, betaine or Various.

The addition of the above foaming agent can provide the main foaming source of the fluoride anti-caries composition, thereby ensuring the excellent foaming property of the fluoride anti-caries composition, making it better used for dental braces or invisible retainers.

In order to improve the synergistic effect of fluoride and peroxide, it is preferable that the above-mentioned fluoride is selected from any one or more of sodium fluoride, potassium fluoride, and sodium monofluorophosphate, preferably sodium fluoride.

In one embodiment of the present application, the fluoride anti-caries composition further includes 0.1 to 2 parts of a stabilizer, preferably the stabilizer is selected from EDTA2Na, poloxamer 407, poloxamer 408, citric acid, glycerin, Any one or more of propylene glycol, sodium citrate, and sodium benzoate.

The addition of the above stabilizers can improve the stability of the fluoride anti-caries composition and prolong its shelf life. The citric acid therein has the effect of regulating pH at the same time. Of course, conventional pH regulators such as phosphoric acid, hydrochloric acid, sodium hydroxide, potassium hydroxide, etc. in the art can also be added to the above fluoride anti-caries composition to maintain the fluoride anti-caries composition. The pH value of the substance is within the above range. This is different from traditional fluorinated foams (traditional fluorinated foams are used once every six months, so in order to take effect quickly, their pH is <5.0, which will inevitably cause damage to oral soft tissues).

In one embodiment of the present application, the above-mentioned fluoride anti-caries composition further includes 0.1 to 2 parts of a flavoring agent, the flavoring agent includes flavor and/or sweetener, preferably the flavor is a fruit-flavored flavor, further, It is preferably mint flavor essence; it is preferred that the sweetener is selected from any one or more of xylitol, erythritol, sucralose, and sodium saccharin, and further, xylitol and sucralose are preferred.

The addition of the above flavoring agents helps to increase the flavor of the fluoride anti-caries composition and is easier to be accepted by users.

In another typical embodiment of the present application, a fluoride anti-caries agent is provided, which is prepared by mixing the aforementioned fluoride anti-caries composition.

The above fluoride anti-caries agent of the present application has a safe dose of fluoride and peroxide, so that the wearer of the braces can use it within 24 hours a day to strengthen the hardness of tooth enamel and prevent dental caries. In addition, peroxide can additionally whiten teeth and reduce the chance of yellowing of teeth during braces

In yet another typical embodiment of the present application, an application of the aforementioned fluoride anti-caries agent in orthodontics is provided, which is added to invisible braces or invisible retainers and then worn and used.

The above of this application is especially suitable for people who wear invisible braces or invisible retainers during the process of orthodontics. By adding fluoride anti-caries agent to the above-mentioned fluorine anti-caries agent to strengthen the hardness of tooth enamel, prevent dental caries from occurring, and make Braces stay clean.

The concentration of fluoride and peroxide in the above-mentioned fluoride anti-caries agent of the present application is all low, so the above-mentioned fluoride anti-caries agent can be continuously used in the human oral cavity within 24 hours a day, preferably by squeezing the foaming bottle to squeeze the fluorine anti-caries The agent is added to the invisible braces or invisible retainer.

Some existing fluorinated foam products generally use pressurized gas cylinders, which are inconvenient to carry and have the risk of explosion. In this application, fine fluorinated foam can be pumped out by squeezing the foaming bottle, which is convenient to carry, safe and reliable.

The beneficial effects of the present application will be further described below in conjunction with examples.

Example 1

Stir and mix the substances as shown in Table 1, finally add 30% hydrogen peroxide and sodium percarbonate, and stir at a stirring speed of 500r/min for 30min to obtain a fluoride anti-caries agent, pH ≈ 5.0.

Table 1

Components in the fluoride anti-caries composition Content in parts by weight of each ingredient (parts) EDTA2Na 0.1 Polosham 407 0.1 citric acid 0.1 glycerin 0.1 Propylene Glycol 0.1 Sodium citrate 0.1 sodium benzoate 0.1 Polysorbate 20 (Tween 20) 0.5 betaine 0.5 xylitol 0.3 sodium saccharin 0.2 mint flavor 0.5 30% hydrogen peroxide <![CDATA[6(equivalent to 1.8 copies of H₂O₂)]]> sodium percarbonate <![CDATA[6(equivalent to 1.3 copies of H₂O₂)]]> sodium fluoride 0.02 Fulvic acid 0.2 water 93.98

Example 2

The difference with Example 1 is that 30% hydrogen peroxide is 6.9 parts, sodium percarbonate is 3.17 parts, and finally the fluoride anti-caries agent is obtained.

Example 3

The difference with Example 1 is that 30% hydrogen peroxide is 0.93 parts, sodium percarbonate is 8.68 parts, and finally the fluoride anti-caries agent is obtained.

Example 4

The difference with Example 1 is that 30% hydrogen peroxide is 9.4 parts, sodium percarbonate is 0.86 parts, and finally the fluoride anti-caries agent is obtained.

Example 5

The difference from Example 1 is that 30% hydrogen peroxide is 4 parts, carbamide peroxide is 0.9 part, no sodium percarbonate is added, and finally the fluoride anti-caries agent is obtained.

Example 6

The difference from Example 1 is that the fluoride anti-caries agent is obtained according to the content of each substance shown in Table 2.

Table 2

Example 7

The difference from Example 1 is that the fluoride anti-caries agent is obtained according to the content of each substance shown in Table 3.

table 3

Components in the fluoride anti-caries composition Content in parts by weight of each ingredient (parts) EDTA2Na 0.31 Polosham 407 0.11 citric acid 0.57 glycerin 0.11 Propylene Glycol 0.12 Sodium citrate 0.12 sodium benzoate 0.53 Tween 20 2 betaine 1 xylitol 0.02 sodium saccharin 0.02 mint flavor 0.06 30% hydrogen peroxide <![CDATA[5(Equivalent to 1.5 H₂O₂)]]> sodium percarbonate <![CDATA[10.76(equivalent to 3.5 H₂O₂)]]> sodium fluoride 0.03 water 90

Example 8

The difference from Example 1 is that the fluoride anti-caries agent is obtained according to the content of each substance shown in Table 4.

Table 4

Components in the fluoride anti-caries composition Content in parts by weight of each ingredient (parts) EDTA2Na 0.1 Polosham 407 0.1 citric acid 0.1 glycerin 0.1 Propylene Glycol 0.1 Sodium citrate 0.1 sodium benzoate 0.1 Tween 20 0.5 betaine 0.5 xylitol 0.3 sodium saccharin 0.2 mint flavor 0.5 30% hydrogen peroxide <![CDATA[6(equivalent to 1.8 copies of H₂O₂)]]> sodium percarbonate <![CDATA[6(equivalent to 1.3 copies of H₂O₂)]]> sodium fluoride 0.02 Fulvic acid 0.16 water 94.02

Example 9

The difference from Example 1 is that the fluoride anti-caries agent is obtained according to the content of each substance shown in Table 5.

table 5

Components in the fluoride anti-caries composition Content in parts by weight of each ingredient (parts) EDTA2Na 0.1 Polosham 407 0.1 citric acid 0.1 glycerin 0.1 Propylene Glycol 0.1 Sodium citrate 0.1 sodium benzoate 0.1 Tween 20 0.5 betaine 0.5 xylitol 0.3 sodium saccharin 0.2 mint flavor 0.5 30% hydrogen peroxide <![CDATA[6(equivalent to 1.8 copies of H₂O₂)]]> sodium percarbonate <![CDATA[6(equivalent to 1.3 copies of H₂O₂)]]> sodium fluoride 0.02 Fulvic acid 0.31 water 93.87

Comparative example 1

The difference from Example 1 is that the fluoride anti-caries agent is obtained according to the content of each substance shown in Table 6.

Table 6

Components in the fluoride anti-caries composition Content in parts by weight of each ingredient (parts) EDTA2Na 0.1 Polosham 407 0.1 citric acid 0.1 glycerin 0.1 Propylene Glycol 0.1 Sodium citrate 0.1 sodium benzoate 0.1 Tween 20 0.5 betaine 0.5 xylitol 0.3 sodium saccharin 0.2 mint flavor 0.5 30% hydrogen peroxide <![CDATA[6(equivalent to 1.8 copies of H₂O₂)]]> sodium percarbonate <![CDATA[6(equivalent to 1.3 copies of H₂O₂)]]> sodium fluoride 0.05 water 95.15

Comparative example 2

The difference from Example 1 is that the fluoride anti-caries agent is obtained according to the content of each substance shown in Table 7.

Table 7

Components in the fluoride anti-caries composition Content in parts by weight of each ingredient (parts) EDTA2Na 0.1 Polosham 407 0.1 citric acid 0.1 glycerin 0.1 Propylene Glycol 0.1 Sodium citrate 0.1 sodium benzoate 0.1 Tween 20 0.5 betaine 0.5 xylitol 0.3 sodium saccharin 0.2 mint flavor 0.5 30% hydrogen peroxide <![CDATA[1(equivalent to 0.3 copies of H₂O₂)]]> sodium percarbonate <![CDATA[1(equivalent to 0.325 H₂O₂)]]> sodium fluoride 0.6 water 96.075

Comparative example 3

The difference from Example 1 is that no peroxide is added, and 97.08 parts of water are added to finally obtain the fluoride anti-caries agent.

The performance test of the fluoride anti-caries agents obtained in Examples 1 to 9 and Comparative Examples 1 to 3 was carried out according to the following method, and the test results are listed in Table 8.

Foaming time: pump the foam twice onto a glass plate, and record the complete defoaming time.

Sensitivity test: pump the foam into the human mouth and rinse for 1 minute, and collect the tester's feelings.

Inlet concentration of fluoride: calculated according to the 1ppm (1mg/L) fluoride concentration intake stipulated in China's "Drinking Water Hygienic Supervision and Management Measures" and the recommended daily use of 2-4mL fluoride foam volume, the fluoride content can be known Should not exceed 500ppm.

Table 8

From the above description, it can be seen that the above-mentioned embodiments of the present invention have achieved the following technical effects:

The addition of peroxide in the fluoride anti-caries composition can kill most of the bacteria in the inner environment of the braces and on the surface of the teeth, so that only a relatively low amount of fluoride needs to be added and through the synergistic effect of the two, the Contain the bacteria that cause dental caries and bad smell at the source, and will not disrupt the flora balance of the overall oral environment. The above-mentioned peroxides are non-toxic components, which can be decomposed into oxygen and water. Because of their certain permeability, using peroxides alone to whiten teeth may cause reversible pulpitis. When used, it reduces dentin demineralization, thereby reducing the penetration of peroxide products into the dental pulp. Therefore, the teeth can be in contact with the above safe dose of fluoride and peroxide for a long time, that is, the wearer of braces can use it within 24 hours a day to strengthen the hardness of tooth enamel, prevent dental caries, and keep the braces clean. In addition, peroxides can additionally break down exogenous pigments, reduce the probability of deposits, and reduce the chance of yellowing of teeth during braces. Peroxides can additionally whiten teeth and reduce the chance of yellowing of teeth that can occur while wearing braces.

Keeping the pH value of the fluoride anti-caries composition at 5-7 is conducive to maintaining its mildness, thus making it more suitable for long-term use.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (10)

1. A fluorine anticaries composition, comprising, in parts by weight:

1-5 parts of peroxide based on hydrogen peroxide;

0.01 to 0.03 part of fluoride;

0.3 to 3 parts of foaming agent;

90-98 parts of water;

wherein the hydrogen peroxide is directly provided for the peroxide, or the peroxide releases hydrogen peroxide after being dissolved in the water, and the pH value of the fluorine anticarious composition is 5-7.

2. The fluorine anticaries composition according to claim 1, wherein the peroxide is selected from any one or more of hydrogen peroxide, sodium percarbonate, urea peroxide, sodium perborate, preferably the peroxide is selected from hydrogen peroxide and sodium percarbonate, further preferably the mass ratio of the hydrogen peroxide to the sodium percarbonate is 1:10 to 10:1, preferably 1:10 to 2:1.

3. The fluorine anticaries composition according to claim 1 or 2, characterized in that the fluorine anticaries composition further comprises fulvic acid, preferably in a mass ratio of the fulvic acid to the hydrogen peroxide of 1:20 to 1:10.

4. A fluorine anticaries composition according to any of claims 1 to 3, wherein the foaming agent is selected from any one or more of sodium dodecyl sulfate, sodium lauryl sulfate, polysorbate 20, sodium lauroyl sarcosinate, betaine.

5. A fluorine anticaries composition according to any of claims 1 to 3, wherein the fluoride is selected from any one or more of sodium fluoride, potassium fluoride, sodium monofluorophosphate, preferably sodium fluoride.

6. A fluorine anticaries composition according to any of claims 1 to 3 further comprising 0.1 to 2 parts of a stabilizer, preferably the stabilizer is selected from any one or more of EDTA2Na, poloxamer 407, poloxamer 408, citric acid, glycerol, propylene glycol, sodium citrate, sodium benzoate.

7. A fluorine anticaries composition according to any of claims 1 to 3 further comprising 0.1 to 2 parts of a flavouring agent comprising flavour and/or sweetener, preferably the flavour is a fruity flavour, further preferably a peppermint flavour; preferably, the sweetener is selected from any one or more of xylitol, erythritol, sucralose and saccharin sodium, and further preferably xylitol and sucralose.

8. A fluorine anticaries agent, characterized in that it is prepared by mixing the fluorine anticaries composition according to any one of claims 1 to 7.

9. Use of a fluorine anticaries agent according to claim 8 for the correction of teeth, wherein the fluorine anticaries agent is applied after being pumped into a concealed mouthpiece or concealed retainer.

10. The use according to claim 9, wherein the fluorine anticaries agent is continuously applied to the human mouth for 24 hours a day, preferably by pumping the fluorine anticaries agent into the invisible dental mouthpiece or the invisible holder by squeezing a bubble.