CN116035925A - Feldspar nano ceramic particle abrasive toothpaste containing simulated enamel mechanical properties - Google Patents

Abstract

The invention belongs to the technical field of toothpaste preparation, and particularly relates to feldspar nano ceramic particle abrasive toothpaste containing simulated enamel mechanical properties. The toothpaste comprises the following components in percentage by weight: 10-60 wt% of feldspar nano ceramic particle abrasive, 1-3 wt% of pharmacodynamic agent, 30-40 wt% of humectant, 0.4-1.0 wt% of adhesive, 1.5-2.5 wt% of foaming agent, 0.1-2.0 wt% of preservative, 0.1-0.5 wt% of sweetener, 1.0-3.0 wt% of acid-base buffer, 0.01-0.05 of compound vitamin, and the balance of deionized water, wherein the sum of the total mass percentages is 100%. The toothpaste not only can be matched with the mechanical property of the tooth enamel and ensure moderate friction force to maintain the cleaning force on dirt, but also can lead the tooth surface to be uniformly stressed and has small abrasion on the tooth enamel.

Description

A feldspathic nano-ceramic particle abrasive toothpaste containing simulated enamel mechanical properties

technical field

The invention belongs to the technical field of toothpaste preparation, in particular to a feldspathic nano-ceramic particle abrasive toothpaste containing simulated tooth enamel mechanical properties.

Background technique

Toothpaste is an important component of daily oral care. One of the main ways it plays a cleaning role is to remove the plaque, pigment and food residue adhering to the tooth surface through friction. Among them, the abrasive is an important component that plays a frictional role. It can roll in the friction interface between the toothbrush and the tooth surface to produce three-body wear. The magnitude of the generated friction will affect both the cleaning effect on dirt and the abrasion on teeth. sex. Therefore, it is not possible to blindly reduce or increase friction. While ensuring a moderate friction force, it is particularly important to evenly disperse the friction force. The hardness and particle size of the abrasive directly affect the degree of friction and stress dispersion at the friction interface between the toothbrush and the tooth surface. The hardness of the abrasive needs to match the hardness of the enamel to produce moderate friction; the larger the particle size of the abrasive, the less specific surface area, and it is more difficult to disperse evenly on the friction interface than small particles, so it is easier to form stress concentration, and it is not as small as small particles. The tooth surface plays the role of grinding and polishing. After brushing, the tooth surface is more likely to be rough, and it is very easy to introduce bacteria and biofilm colonization.

At present, the main abrasives in the optional toothpaste ingredients on the market are silicon dioxide, calcium carbonate and other particles with relatively high hardness and particle size of micron level. Although they can clean the tooth surface, they have a large wear on the tooth enamel. It is also easy to increase the roughness of the tooth surface.

Although the toothpaste prepared by Chinese patent application CN109264728A can achieve low wear and high cleaning effect, the evaluation method it relies on is RDA, that is, the rate of dentin wear, which matches the dentin, while the surface of normal human teeth is mostly enamel , Only a small number of elderly people or patients with severe bruxism have tooth surfaces that are basically dentin. The evaluation criteria based on ISO 11069 involve the wear rate of dentin (RDA) and the wear rate of enamel (REA). However, the existing patents do not involve the evaluation of the enamel wear rate of REA.

Contents of the invention

The purpose of the present invention is to provide a toothpaste containing feldspathic nano-ceramic particle abrasives aiming at the problems in the prior art. The toothpaste can not only match the mechanical properties of tooth enamel, ensure moderate friction to maintain the cleaning power of dirt, but also make the tooth surface evenly stressed, with little wear on tooth enamel.

Another object of the invention of the present application is to provide a preparation method of the toothpaste mentioned above. The preparation method is simple and easy, and has strong operability.

In order to realize above object of the invention, concrete technical scheme of the present invention is:

A toothpaste containing feldspathic nano-ceramic particle abrasive, which contains the following components in percentage:

10-60 wt% feldspar nano-ceramic particle abrasive, 1-3 wt% medicinal agent, 30-40 wt% humectant, 0.4-1.0 wt% binder, 1.5-2.5 wt% foaming agent, 0.1 -2.0 wt% preservative, 0.1-0.5 wt% sweetener, 1.0-3.0 wt% acid-base buffer, 0.01-0.05 multivitamins, and the rest of the ingredients are deionized water, the sum of the total mass percentage is 100%.

Further, the feldspathic nano-ceramic particle abrasive is used as an abrasive for toothpaste in this application, and the particle size is 32-54 nm. The mechanical properties of feldspathic nano-ceramic particles under this particle size, including elastic modulus and hardness, are similar to those of tooth enamel. High activity, fewer pores formed after sintering, good internal bonding force, and reduced brittleness. In the process of reciprocating friction with enamel, the particles of feldspar nano-ceramic particles rubbed off are nano-scale wear debris, which can be evenly distributed on the surface of enamel, local stress is dispersed, less heat is produced, and the amount of wear is low and uniform. It can play a similar polishing effect on tooth enamel.

As a preferred implementation method in the present application, the humectant is any one or a mixture of sorbitol, xylitol, glycerin, propylene glycol and polyethylene glycol.

As a preferred implementation method in this application, the binder is any one or a mixture of hydroxyethyl cellulose, hydroxybutyl methyl cellulose, and hydroxymethyl cellulose.

As a preferred implementation method in the present application, the preservative is sodium benzoate, butylparaben or potassium sorbate.

As a better implementation method in this application, the acid-base buffer is phosphate buffer (usually PH5.7--8.0, 0.2M); the foaming agent is sodium bicarbonate; the The sweetener is sodium saccharin.

As a better implementation method in the present application, the multivitamins are selected from any one or a mixture of vitamin B3, vitamin B6, vitamin C, and vitamin E.

As preferably, the preparation method of the toothpaste that contains feldspathic nano-ceramic particle abrasive as described above, comprises the following steps:

Weigh each raw material in proportion, and then mix the binder and humectant together to obtain a pre-dispersion; dissolve the sweetener and acid-base buffer in deionized water and stir thoroughly to obtain a pre-dissolved liquid; pre-dissolved The mixed liquid and the pre-dispersion liquid are mixed and swelled into a homogeneous glue, and the aged liquid is obtained through aging; finally, the aged liquid is mixed with friction agent, foaming agent, preservative and multivitamins, stirred, milled and vacuum degassed, and finally Obtain the paste composition of the toothpaste.

The preparation method of the preferred toothpaste is as follows:

First mix the adhesive and humectant together to obtain a pre-dispersion; dissolve the sweetener and acid-base buffer in deionized water and mix thoroughly to pH 8.5 and control the reaction temperature to 80°C to obtain a pre-dissolved liquid; Mix and swell the pre-dissolved liquid and the pre-dispersed liquid to form a homogeneous glue, and age it at 65-100°C for 10 minutes to obtain the aged liquid; Stirring, milling, and vacuum degassing under the condition of a vacuum degree of -0.09MPa for 20-40 minutes, standing still for 24-48 hours after degassing, and finally obtaining the paste composition of the toothpaste.

In this application, feldspar-based ceramic materials are used, which match the hardness and elastic modulus of enamel. Selecting feldspar-based ceramic abrasives with a suitable particle size range matches the friction and wear properties of natural teeth, which can reduce wear to a certain extent. , Protect tooth tissue.

Compared with prior art, positive effect of the present invention is reflected in:

The abrasive material of the toothpaste is mainly abrasive material of feldspathic nano-ceramic particles. Compared with traditional hard or soft particles, feldspar nano-ceramic particles match the mechanical properties of tooth enamel, which not only ensures the effective friction force required for the toothbrush to remove dirt, but also forms a uniform nano-particle abrasive at the friction interface. Chips form a stress spreader that prevents excessive wear of the tooth enamel.

Description of drawings

Figure 1 (A) is the surface morphology of the feldspar-based nano-ceramic paste, and (B) is the measurement diagram of the particle size of the nanoparticles in the paste.

Detailed ways

In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be described in further detail below in conjunction with specific embodiments, but it should not be understood that the scope of the above subject of the present invention is limited to the following examples. Without departing from the above-mentioned technical idea of the present invention, various replacements and changes made according to common technical knowledge and conventional means in this field shall be included in the scope of the present invention.

In this application document, % means wt% unless otherwise specified; the raw materials used are all commercially available products unless otherwise specified.

The feldspathic nano-ceramic particles adopted in the following examples have a particle size of 32-54 nm and are all purchased through commercial channels, such as purchased from Aidite (Qinhuangdao) Technology Co., Ltd. (website: https://www.aidite .com/zh/homePage).

Example 1:

A toothpaste containing feldspathic nano-ceramic particle abrasive, the toothpaste is composed of the following components in mass percentage: 20 wt% feldspar-based nano-ceramic particle abrasive (1wt% can be regarded as 1g), 30 wt% humectant , 1.0 wt% binder, 2wt% foaming agent, 1 wt% preservative, 0.5 wt% sweetener, 3.0 wt% acid-base buffer, 0.05 wt% multivitamin, the rest of the ingredients are deionized water, the total mass The sum of the percentages is 100%.

Among them, the paste containing feldspar nano-ceramic particles was observed by field emission scanning electron microscopy, and the particle size of feldspar-like nano-ceramic particles was found to be about 40 μm (see Figure 1).

The moisturizing agent in the ingredients is sorbitol, the binder in the ingredients is hydroxyethyl cellulose and hydroxymethyl cellulose, the foaming agent in the ingredients is sodium bicarbonate, the preservative in the ingredients is sodium benzoate, and the ingredients The sweetener is sodium saccharin, the acid-base buffer in the ingredients is phosphate buffer, and the multivitamins in the ingredients include vitamin B3, vitamin B6, vitamin C, and vitamin E (the contents of each vitamin in the multivitamins are shown in Table 1 ).

The preparation method of this toothpaste is as follows:

First mix the adhesive and humectant together to obtain a pre-dispersion; dissolve the sweetener and acid-base buffer in deionized water, stir and mix thoroughly to make the pH 8.5, and control the reaction temperature to 80°C to obtain the pre-dispersion. Dissolving liquid; mix and swell the pre-dissolved liquid and pre-dispersed liquid to form a homogeneous glue, and age it at 75°C for 10 minutes to obtain the aged liquid; finally mix the aged liquid with friction agent, foaming agent, preservative and The multivitamins were mixed, stirred, and ground, and vacuum degassed under the condition of a vacuum degree of -0.09MPa for 30 minutes, and left standing for 30 hours after degassing to finally obtain the paste composition of the toothpaste.

Example 2:

A toothpaste containing feldspathic nano-ceramic particle abrasives, the toothpaste is composed of the following components in mass percentage: 40 wt% feldspar-based nano-ceramic particle abrasives, 30 wt% humectant, 1.0 wt% binding agent, 2 wt% foaming agent, 1 wt% preservative, 0.5 wt% sweetener, 3.0 wt% acid-base buffer, 0.05 wt% multivitamin, the rest of the ingredients are deionized water, the sum of the total mass percentage is 100% .

The moisturizing agent in the ingredients is sorbitol, the binder in the ingredients is hydroxyethyl cellulose and hydroxymethyl cellulose, the foaming agent in the ingredients is sodium bicarbonate, the preservative in the ingredients is sodium benzoate, and the ingredients The sweetener in the ingredients is sodium saccharin, the acid-base buffer in the ingredients is phosphate buffer, and the multivitamins in the ingredients include vitamin B3, vitamin B6, vitamin C, and vitamin E.

The preparation method of this toothpaste is:

Mix the binder and humectant together to obtain a pre-dispersion; dissolve the sweetener and acid-base buffer in deionized water, stir and mix thoroughly to obtain a pre-dissolved liquid; mix the pre-dissolved liquid and the pre-dispersed liquid to swell It is a homogeneous glue, which is aged at 85°C for 10 minutes to obtain an aged liquid; finally, the aged liquid is mixed with friction agent, foaming agent, preservative and multivitamin, stirred, and ground in a vacuum. Under the condition of -0.09MPa, carry out vacuum degassing for 35 minutes, stand still for 40 hours after degassing, and finally obtain the paste composition of the toothpaste.

Example 3:

A toothpaste containing feldspathic nano-ceramic particle abrasives, the toothpaste is composed of the following components in mass percentage: 60 wt% feldspar-based nano-ceramic particle abrasives, 30 wt% humectant, 1.0 wt% binding agent, 2 wt% foaming agent, 1 wt% preservative, 0.5 wt% sweetener, 3.0 wt% acid-base buffer, 0.05 wt% multivitamin, the rest of the ingredients are deionized water, the sum of the total mass percentage is 100% .

The moisturizing agent in the ingredients is sorbitol, the binder in the ingredients is hydroxyethyl cellulose and hydroxymethyl cellulose, the foaming agent in the ingredients is sodium bicarbonate, the preservative in the ingredients is sodium benzoate, and the ingredients The sweetener in the ingredients is sodium saccharin, the acid-base buffer in the ingredients is phosphate buffer, and the multivitamins in the ingredients include vitamin B3, vitamin B6, vitamin C, and vitamin E.

The preparation method of this toothpaste is as follows:

Mix the binder and humectant together to obtain a pre-dispersion; dissolve the sweetener and acid-base buffer in deionized water and stir thoroughly to obtain a pre-dissolved liquid; mix and swell the pre-dissolved liquid and the pre-dispersed liquid to form Homogeneous glue, aging at 90°C for 10 minutes to obtain an aging solution; finally, mixing the aging solution with friction agents, foaming agents, preservatives and multivitamins, stirring, grinding and Carry out vacuum degassing under conditions for 28 minutes, stand still for 36 hours after degassing, and finally obtain the paste composition of the toothpaste.

The damage effect of the toothpaste made in Examples 1, 2, 3 and Comparative Examples 1, 2, 3, and 4 on enamel and dentin is according to ISO11609:2017 "Dentistry - Dentifrice - Requirements, Test Methods and Signs" method test, and the test results are recorded in Table 1. REA stands for rate of enamel wear and RDA stands for rate of dentin wear

The toothpaste prepared in Examples 1, 2, 3 and Comparative Examples 1, 2, 3, and 4 are tested according to the method for evaluating the cleaning rate (PCR) of abrasive film in toothpaste published by the Dental Association ADA. The results are reported in Table 1.

Table 1 The specific ratio of toothpaste and the measured RDA, REA, PCR values:

Can find from the above table, the embodiment 1,2,3 of the toothpaste that contains feldspathic nano-ceramic abrasive compares with the traditional toothpaste that contains silicon dioxide of comparative example 1,2,3,4, and its tooth enamel wear rate REA and dentin wear rate RDA were significantly lower than those of Comparative Examples 1, 2, 3, and 4, and the cleaning power PCR was significantly better than that of Comparative Examples 1, 2, 3, and 4.

The above examples are only preferred implementations of this patent, but the protection scope of this patent is not limited thereto. It should be pointed out that for those skilled in the art, on the premise of not departing from the principle of this patent, some improvements and modifications can be made according to the technical solution and patent concept of this patent, and these improvements and modifications should also be considered within the scope of protection of this patent.

Claims (10)

1. a toothpaste containing feldspathic nano-ceramic particle abrasive, is characterized in that containing the component of following percentage composition: 10-60 wt% feldspar nano-ceramic particle abrasive, 1-3 wt% medicinal agent, 30-40 wt% humectant, 0.4-1.0wt% binder, 1.5-2.5 wt% foaming agent, 0.1 -2.0 wt% preservative, 0.1-0.5 wt% sweetener, 1.0-3.0 wt% acid-base buffer, 0.01-0.05 multivitamins, and the rest of the ingredients are deionized water, the sum of the total mass percentage is 100%. 2. the toothpaste containing feldspathic nano-ceramic particle abrasive as claimed in claim 1, is characterized in that: described feldspathic nano-ceramic particle abrasive is the abrasive of toothpaste, and particle diameter is 32-54 nm. 3. The toothpaste containing feldspathic nano-ceramic particle abrasives as claimed in claim 1, characterized in that: said medicinal agent is arginine. 4. the toothpaste that contains feldspathic nano-ceramic particle abrasive as claimed in claim 1, is characterized in that: described humectant is any one or more in sorbitol, xylitol, glycerin, propylene glycol and polyethylene glycol mixture of species. 5. the toothpaste that contains feldspathic nano-ceramic particle abrasive as claimed in claim 1, is characterized in that: described binding agent is in hydroxyethyl cellulose, hydroxybutyl methyl cellulose, hydroxymethyl cellulose Any one or a mixture of several. 6. the toothpaste that contains feldspathic nano ceramic particle abrasive as claimed in claim 1, is characterized in that: described preservative is sodium benzoate, butylparaben or potassium sorbate. 7. The toothpaste containing feldspathic nano-ceramic particle abrasives as claimed in claim 1, characterized in that: said acid-base buffer is a phosphate buffer. 8. The toothpaste containing feldspathic nano-ceramic particle abrasives as claimed in claim 1, characterized in that: the foaming agent is sodium bicarbonate; the sweetener is sodium saccharin. 9. the toothpaste that contains feldspathic nano-ceramic particle abrasive as claimed in claim 1, is characterized in that: in described multivitamin, be selected from any one or several in vitamin B3, vitamin B6, vitamin C, vitamin E mixture of species. 10. the preparation method of the toothpaste containing feldspathic nano-ceramic particle abrasive as described in any one claim in claim 1-9, it is characterized in that comprising the following steps: Weigh each raw material in proportion, and then mix the binder and humectant together to obtain a pre-dispersion; dissolve the sweetener and acid-base buffer in deionized water and stir thoroughly to obtain a pre-dissolved liquid; pre-dissolved The mixed liquid and the pre-dispersion liquid are mixed and swelled into a homogeneous glue, and the aged liquid is obtained through aging; finally, the aged liquid is mixed with friction agent, medicinal agent, foaming agent, preservative and multivitamin, stirred, milled and vacuumized Degassing, and finally the paste composition of toothpaste is obtained.

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