CN115813781A - Modified oxyresveratrol and preparation method and application thereof - Google Patents

Abstract

The invention discloses a modified oxyresveratrol and a preparation method and application thereof, and the modified oxyresveratrol comprises the following raw material components in percentage by weight: 1-3% of oxyresveratrol, 5-10% of water-soluble alcohol, 10-50% of polyglyceryl nonionic surfactant, 1-5% of oil-soluble ester and 32-83% of water. The nano vesicles formed by the preparation process are stable. According to the invention, the nonionic surfactant is used as a modifier to form the modified oxyresveratrol with a stable nano vesicle structure, so that the contact between the oxyresveratrol and oxygen is greatly reduced and the stability is better compared with the non-coated technology. The modified oxidized resveratrol of the invention promotes the transmission on the skin and increases the transdermal absorption performance, thereby enhancing the effects of oxidation resistance, saccharification resistance and whitening. Meanwhile, the water solubility of the resveratrol is enhanced, the application rate of the oxyresveratrol in preparations is improved, and the application value of the resveratrol in the fields of medicines and cosmetics is enhanced.

Description

A kind of modified oxidized resveratrol and its preparation method and application

technical field

The invention relates to the technical field of cosmetics, in particular to a modified oxidized resveratrol and its preparation method and application.

Background technique

Oxidized resveratrol (OXY or ORV) is a naturally occurring polyphenol stilbene found in the Moraceae family, such as the mulberry tree, and in plants such as grapes and peanuts. Oxidized resveratrol is colorless or light yellow rod-like crystals, needle-like crystals. Oxidized resveratrol, as a homologue of resveratrol, has a variety of beneficial biological activities, such as tyrosinase (Tyrosinase, an enzyme necessary for the synthesis of melanin in animals and plants) inhibitory activity, fruit and vegetable It has antiseptic and antibacterial activity, anti-herpes simplex virus activity, anti-varicella zoster virus activity and anti-HIV activity, and also has anti-inflammatory, anti-inflammatory, anti-oxidation, anti-glycation, anti-apoptosis and neuroprotective effects.

Oxidized resveratrol has the following structure:

Compared with resveratrol (Res), it has one more hydroxyl group at the meta-position of the hydroxyl group on the 2-position benzene ring of the 1,2-stilbene skeleton, which extends the electron-rich conjugated system, making it more effective than Res It is easier to be oxidized, so the antioxidant activity of OXY is stronger than that of Res.

Although oxidized resveratrol has high biological activity, it is easily oxidized and unstable at high temperature and in formulations due to its reducing property; its water solubility is also extremely poor; it is also unstable under light conditions and is easily metabolized; The transdermal absorption effect is not good, and the bioavailability is low. With the development of technology, how to improve the stability, water solubility and transdermal absorption of oxidized resveratrol has gradually become a hot research direction, but there are relatively few studies on the transdermal absorption of oxidized resveratrol .

Therefore, a modified oxidized resveratrol is provided, which can improve the transdermal absorption performance of oxidized resveratrol, and also has good stability and water solubility, which is important for popularizing the application of oxidized resveratrol meaning.

Contents of the invention

In order to overcome the deficiencies of the prior art, the first object of the present invention is to provide a modified oxidized resveratrol, which uses mild materials and improves the transdermal properties of oxidized resveratrol through deformable vesicle technology Absorbency, stability, water solubility.

The second object of the present invention is to provide a method for preparing the above-mentioned modified oxidized resveratrol.

The third object of the present invention is to provide an application of the above-mentioned modified oxidized resveratrol.

Realize that one of purpose of the present invention can realize by adopting following technical scheme:

A modified oxidized resveratrol, the modified oxidized resveratrol is a vesicle structure, including the following raw material components in weight percent: 1-3% oxidized resveratrol, 5-10% water-soluble Alcohol, 10-50% polyglyceryl nonionic surfactant, 1-5% oil-soluble ester, 32-83% water.

Further, the modified oxidized resveratrol includes the following raw material components in weight percent: 1-3% oxidized resveratrol, 6-9% water-soluble alcohol, 20-40% polyglyceryl non-ionic Surfactant, 2-4% oil soluble ester, 45-70% water.

Further, the water-soluble alcohol is one or a combination of two or more polyols, and the oil-soluble ester is sorbitan palmitate.

Further, the polyglyceryl nonionic surfactant is one or a combination of polyglyceryl-10 laurate and polyglyceryl-10 dipalmitate.

Further, the mass ratio of polyglyceryl-10 laurate to polyglyceryl-10 dipalmitate in the polyglyceryl nonionic surfactant is 1:(0.25-2).

Two of the goals of the present invention can be achieved by taking the following technical solutions:

A preparation method for any of the above-mentioned modified oxidized resveratrol, comprising the following steps:

S1. Dissolving oxidized resveratrol in water-soluble alcohol, adding polyglycerol nonionic surfactant and oil-soluble ester, stirring and heating to obtain the first mixed solution;

S2. Continue to add water to the first mixed solution prepared in step S1 to mix and stir to obtain a uniform emulsion;

S3. Homogenize the emulsion obtained in step S2 to obtain the modified oxidized resveratrol.

Further, in the step S1, after adding the polyglycerin nonionic surfactant, the temperature is controlled to be 50-80°C.

Further, the pressure in the homogenization treatment in the step S3 is 500 bar-1500 bar, and the number of cycles is 4-8 times to obtain the modified oxidized resveratrol.

Realize the object three of the present invention can reach by taking following technical scheme:

The application of any modified oxidized resveratrol described above or the modified oxidized resveratrol prepared by the method for preparing modified oxidized resveratrol described above, the modified oxidized resveratrol Retrol is used in antioxidant products and/or in tyrosinase inhibiting products.

Further, the mass proportion of the modified oxidized resveratrol in the antioxidant product and/or tyrosinase inhibiting product is 0.1-8%.

Compared with the prior art, the beneficial effects of the present invention are:

1. The modified oxidized resveratrol of the present invention adopts a nonionic surfactant as a modifying agent. Because it has a hydrophobic end and a hydrophilic end, it forms nanovesicles through charge self-assembly, and the oxidized resveratrol can be Spontaneously encapsulated in the bimolecular layer to form modified oxidized resveratrol with a stable nanovesicle structure. Compared with the unencapsulated technology, the contact between oxidized resveratrol and oxygen is greatly reduced, and the stability is better . The modified oxidized resveratrol of the present invention promotes its transmission in the skin, increases its transdermal absorption performance, thereby enhancing its anti-oxidation, anti-glycation and whitening effects. At the same time, it solves the problem that conventional oxidized resveratrol is not easy to dissolve in water, enhances its water solubility, improves the application of oxidized resveratrol in preparations, enhances the stability of oxidized resveratrol, and can improve its Application value in the fields of food, medicine, health care and cosmetics.

2, the preparation method of modified oxidized resveratrol of the present invention, the present invention adopts non-ionic surfactant as modifying agent, because it has hydrophobic end and hydrophilic end, forms nanovesicle by charge self-assembly, can put The oxidized resveratrol is spontaneously encapsulated in the bimolecular layer, and the encapsulation is preferably processed by high-pressure homogeneous circulation, which is easy to operate and rapid in preparation. The high-pressure homogeneous circulation treatment can improve the uniformity and stability of the product; reduce the reaction time.

3. In the present invention, the modified oxidized resveratrol is directly used in anti-oxidation products and tyrosinase-inhibiting products as an auxiliary agent or main component, which has good water solubility and stability, and can also improve its permeability. Skin absorption properties.

Description of drawings

FIG. 1 is a comparison chart of the penetration test data of Example 1 and Comparative Example 1.

Detailed ways

The technical solutions of the present invention will be clearly and completely described below in conjunction with specific embodiments. Apparently, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

The test methods used in the following experimental examples are conventional methods unless otherwise specified; the materials and reagents used are commercially available reagents and materials unless otherwise specified.

At present, the oxidized resveratrol known to the public has anti-oxidation, anti-inflammatory, anti-tumor, anti-hyperlipidemia and neuroprotective effects, and also has biological activities such as improving Parkinson's disease. Compared with resveratrol, oxidized resveratrol has stronger antioxidant properties and can also inhibit the activity of tyrosinase. Oxidized resveratrol is used in many fields because of its high biological activity. The oxidized resveratrol prepared by the existing preparation method has improved its water solubility and stability, but failed to improve its transdermal absorption performance. In addition, there are some oxidized resveratrol made from Tween surfactants, which have a certain increase in water solubility, stability and bioavailability, but the surfactants used are Tween surfactants. , which is a medium-risk component in the EWG classification, and has certain risks to the body and health. Therefore, it is particularly important to prepare modified oxidized resveratrol with mild materials, and improve its transdermal absorption performance while improving its water solubility and stability. Therefore, the present invention provides a modified oxidized resveratrol and its preparation method and application.

A modified oxidized resveratrol, the modified oxidized resveratrol is a vesicle structure, including the following raw material components in weight percentage: 1-3% oxidized resveratrol, 5-10% water-soluble alcohol , 10-50% polyglyceryl nonionic surfactant, 1-5% oil-soluble ester, 32-83% water.

In one of the embodiments, the water-soluble alcohol is one or a combination of two or more polyols, and the oil-soluble ester is sorbitan palmitate.

Among them, the preferred water-soluble alcohol is butanediol.

Nonionic surfactants have lipophilic ends and hydrophilic ends, which can self-assemble into vesicle structures through intermolecular and electrostatic interactions using hydrophilic-lipophilic balance and packing parameters. The addition of water-soluble alcohol to polyglyceryl nonionic surfactant can adjust the hydrophilic end, and the addition of oil-soluble ester can adjust the lipophilic end. This application adopts non-ionic surfactants with hydrophilic-lipophilic balance and stacking parameters to form a hydrophilic inner cavity and lipophilic capsule wall through intermolecular interaction, and can spontaneously wrap oxidized resveratrol in a bimolecular layer. Oxidized resveratrol forming stable nanovesicles, thereby modulating vesicle size and stability. Compared with the traditional way of encapsulating oxidized resveratrol with lecithin or cyclodextrin, the vesicle structure formed by encapsulating oxidized resveratrol with the non-ionic surfactant selected in this application is a single-chain structure, and its structural deformation ability is stronger. powerful. At the same time, adding water-soluble alcohols and oil-soluble esters can increase the application of oxidized resveratrol in preparations, enhance the stability of oxidized resveratrol and thus improve the bioavailability of oxidized resveratrol.

In one of the embodiments, the polyglyceryl nonionic surfactant is one or both of polyglyceryl-10 laurate and polyglyceryl-10 dipalmitate.

The molecular weight of the polyglyceryl nonionic surfactant is above 760, wherein the preferred polyglyceryl nonionic surfactant has a molecular weight of 800-1500. Polyglyceryl-10 laurate has excellent emulsifying properties, and compared with other surfactants, it can show better oxidation stability and acid and alkali resistance stability. Due to its polyhydric hydrophilic structure, it has good Water-locking function and moisturizing effect, it does not contain epoxy group and EO structure, the raw materials are all plant sources, green and safe, non-irritating to the skin, and it also has certain antibacterial properties. Polyglycerol-10 dipalmitate can improve the compatibility between anionic surfactants and skin, it can effectively release the active ingredients in cosmetics and the ability to penetrate the surface of the human body, improve their water holding capacity, and improve the effective The role of components. Therefore, using one or both of polyglyceryl-10 laurate and polyglyceryl-10 dipalmitate can better exert the effect of oxidized resveratrol and enhance its transdermal absorption performance.

In one of the embodiments, the mass ratio of polyglyceryl-10 laurate to polyglyceryl-10 dipalmitate in the polyglyceryl nonionic surfactant is 1:(0.25-2).

Among them, the mass ratio of polyglyceryl-10 laurate and polyglyceryl-10 dipalmitate is 1: (0.25-2), and the different mass ratios of the two affect the size of the vesicle lumen and the firmness of the outer vesicle wall . Among them, the quality of polyglyceryl-10 dipalmitate is 0.25-2 times that of polyglyceryl-10 laurate, and nanovesicles with stable size and size can be effectively prepared within this multiple range.

In one of the embodiments, after adding the polyglycerol nonionic surfactant, the temperature is controlled to be 50-80°C.

The temperature can promote the polyglyceryl nonionic surfactant to better form nanovesicles, so it is carried out at 50-80° C., at this temperature, the oxidized resveratrol can better form the modified oxidized resveratrol.

In one of the embodiments, the pressure in the homogeneous circulation treatment is 500 bar-1500 bar, the number of cycles is 4-8 times, and the obtained transparent to translucent liquid is the modified oxidized resveratrol.

With homogeneous cycle processing, pressure and cycle times can affect the uniformity and stability of the product. If the pressure is too low, no vesicles can be formed, and only ordinary emulsion can be formed; if the pressure is too high, the pressure value is likely to be unstable, the requirements for equipment are too high, and the temperature rises too fast, which will affect the stability of oxidized resveratrol. Therefore, the treatment under the conditions of a pressure of 500 bar-1500 bar and a cycle number of 4-8 times can improve the uniformity and stability of the oxidized resveratrol.

The present invention also provides an application of the modified oxidized resveratrol described in any one of the above, wherein the modified oxidized resveratrol is directly used in anti-oxidation products and/or tyrosinase-inhibiting products as auxiliary agent or main ingredient. When the modified oxidized resveratrol of the present invention is used as an auxiliary agent or a main component in a product, it has good water solubility and stability, and can also improve its transdermal absorption performance.

In the following, the modified oxidized resveratrol of the present invention and its preparation method will be described with specific examples.

Example 1

Preparation of modified oxidized resveratrol

The preparation method of described oxidized resveratrol comprises the following steps:

(1) Dissolve 1% oxidized resveratrol in 5% butanediol, add 10% polyglycerol-10 laurate, 10% polyglycerol-10 dipalmitate, 5% sorbitan palmitate, Then heated to 50°C, mixed evenly to obtain a mixed solution;

(2) Pour 69% water at 50°C into the mixed solution in step (1), stir evenly and obtain an emulsion with a homogenizer at 5000rpm;

(3) Homogenize the milky liquid obtained in step (2) 8 times under a pressure of 500 bar to obtain a translucent liquid which is the modified oxidized resveratrol.

Example 2

The preparation method of described oxidized resveratrol comprises the following steps:

(1) Dissolve 5% oxidized resveratrol in 10% butanediol, add 10% polyglycerol-10 laurate, 15% polyglycerol-10 dipalmitate, 3% sorbitan palmitate, Then heated to 80°C, mixed evenly to obtain a mixed solution;

(2) Pour 57% water at 80°C into the mixed solution in step (1), stir evenly and obtain an emulsion with a homogenizer at 5000rpm;

(3) Homogenize the milky liquid obtained in step (2) for 6 times under a pressure of 1000 bar to obtain a translucent liquid which is the modified oxidized resveratrol.

Example 3

The preparation method of described oxidized resveratrol comprises the following steps:

(1) Dissolve 3% oxidized resveratrol in 8% butanediol, add 30% polyglycerol-10 laurate, 20% polyglycerol-10 dipalmitate, 2% sorbitan palmitate, Then heated to 60°C, mixed evenly to obtain a mixed solution;

(2) Pour 37% water at 60°C into the mixed solution in step (1), stir evenly and obtain an emulsion with a homogenizer at 5000rpm;

(3) Homogenize the milky liquid obtained in step (2) for 5 times at a pressure of 1500 bar to obtain a translucent liquid which is the modified oxidized resveratrol.

Example 4

The preparation method of described oxidized resveratrol comprises the following steps:

(1) Dissolve 3% oxidized resveratrol in 10% butanediol, add 25% polyglycerol-10 laurate, 2% sorbitan palmitate, then heat to 70°C, mix well to obtain a mixed solution ;

(2) Pour 60% water at 70°C into the mixed solution in step (1) and stir evenly to obtain an emulsion with a homogenizer at 5000 rpm;

(3) Homogenize the milky liquid obtained in step (2) for 5 times at a pressure of 1500 bar to obtain a translucent liquid which is the modified oxidized resveratrol.

Example 5

The preparation method of described oxidized resveratrol comprises the following steps:

(1) Dissolve 3% oxidized resveratrol in 10% butanediol, add 15% polyglycerol-10 dipalmitate, 2% sorbitan palmitate, then heat to 70°C, mix well to obtain a mixture liquid;

(2) Pour 70% water at 70°C into the mixed solution in step (1) and stir evenly to obtain an emulsion with a homogenizer at 5000 rpm;

(3) Homogenize the milky liquid obtained in step (2) for 5 times at a pressure of 1500 bar to obtain a translucent liquid which is the modified oxidized resveratrol.

Example 6

The preparation method of described oxidized resveratrol comprises the following steps:

(1) Dissolve 3% oxidized resveratrol in 10% butanediol, add 10% polyglycerol-10 laurate, 15% polyglycerol-10 dipalmitate, 3% sorbitan palmitate, Then heated to 70°C, mixed evenly to obtain a mixed solution;

(2) Pour 59% water at 70° C. into the mixed solution in step (1) and stir evenly to obtain an emulsion with a homogenizer at 5000 rpm;

(3) The milky liquid obtained in step (2) was homogenized under high pressure for 8 times at a pressure of 300 bar to obtain an oxidized resveratrol emulsion.

Comparative example 1

Oxidized resveratrol is not encapsulated by the preparation method of the present invention.

Comparative example 2

(1) Dissolving 3% oxidized resveratrol in 10% butanediol, adding 10% Tween 80, 3% sorbitan palmitate, then heating to 70°C, mixing evenly to obtain a mixed solution;

(2) Pour 74% water at 70°C into the mixed solution in step (1) and stir evenly to obtain an emulsion with a homogenizer at 5000 rpm;

(3) Homogenize the milky liquid obtained in step (2) six times under a pressure of 1000 bar to obtain an oxidized resveratrol emulsion.

Comparative example 3

The preparation method of described oxidized resveratrol comprises the following steps:

(1) Dissolving 3% oxidized resveratrol in 10% butanediol, then adding 10% polyglycerol-10 laurate, then heating to 70°C, and mixing evenly to obtain a mixed solution;

(2) Pour 62% water at 70°C into the mixed solution in step (1) and stir evenly to obtain an emulsion with a homogenizer at 5000 rpm;

(3) The milky liquid obtained in step (2) was homogenized under high pressure for 7 times at a pressure of 800 bar to obtain an oxidized resveratrol emulsion.

Comparative example 4

The preparation method of described oxidized resveratrol comprises the following steps:

(1) 3% oxidized resveratrol, 10% polyglycerol-10 laurate and 5% sorbitan palmitate are then heated to 70°C and mixed evenly to obtain a mixed solution;

(2) Pour 69% water at 70°C into the mixed solution in step (1), stir evenly and obtain an emulsion with a homogenizer at 5000rpm;

(3) The milky liquid obtained in step (2) was homogenized under high pressure for 7 times at a pressure of 800 bar to obtain an oxidized resveratrol emulsion.

Effect evaluation and testing

(1) Permeation-promoting test

Franz diffusion cell experiment: using isolated pigskin test, the exposed skin area in the diffusion cell is 1.35cm ² , and the volume of the receptor chamber is 4.3mL. Phosphate buffer solution with a pH of 5.8 and absolute ethanol with a volume ratio of 50:50 were used as the receiving solution. Take 200 μL of the emulsions of Examples 1-6 and Comparative Examples 1-2 and apply them evenly on the skin, and cover with a film to prevent evaporation. Test the transdermal absorption of oxidized resveratrol emulsion by HPLC at 1h, 3h, 6h, 12h, 24h, and 48h, record the influence of different treatments on the penetration accumulation of isolated pig skin at different times, and the unit of penetration accumulation is μg/cm ² . The results are shown in Table 1 and Figure 1 below.

The permeation-promoting experiment result of table 1 embodiment 1-6 and comparative example 1-4

As can be seen from the data in Table 1, different treatments have different impacts on the cumulative penetration of isolated pigskin, and the cumulative penetration of isolated pigskin in Examples 1-6 is better than Comparative Example 1. Modified oxidized resveratrol has higher transdermal absorption performance than unencapsulated oxidized resveratrol, enhancing its effect on the skin. Among them, the cumulative permeation amount of Example 2 reaches 172 μg/cm ² , and the cumulative permeation effect is the best. Comparative Example 3 lacks oil-soluble esters relative to Examples 1-6, Comparative Example 4 lacks water-soluble alcohols relative to Examples 1-6, and the permeation accumulation of Examples 1-6 is all above 143 μg/cm ² The cumulative penetration amount of 3 was 101 μg/cm ² , and that of Comparative Example 4 was 107 μg/cm ² . Obviously, the transdermal absorption properties of Examples 1-6 are better than those of Comparative Example 3 and Comparative Example 4. A single nonionic surfactant cannot form vesicles but forms micelles. The present invention adjusts the water-oil balance of nonionic surfactants by adding water-soluble alcohols and oil-soluble esters, and adopts a method of matching hydrophilic-lipophilic balance and stacking parameters. Nonionic surfactants are required to form encapsulated vesicles. Comparative Example 3 and Comparative Example 4 only form ordinary micelles but not vesicle structures, and the oxidized resveratrol encapsulated in them has low stability and transdermal absorption performance. In addition, it can also be seen from the data in Figure 1 that the cumulative amount of penetration in Example 1 is significantly better than that of the unwrapped sample, further illustrating that the nano-encapsulation using this process improves the permeability of oxidized resveratrol and improves the permeability of oxidized resveratrol. The transdermal absorption properties of alcohol enhance its effect on the skin.

(2) Zebrafish test inhibits melanin production

Apply wild-type AB strain zebrafish (Danio rerio) spawning test from a reliable source. Select healthy zebrafish embryos 6-8 hours after fertilization. Blank group: 20 fish embryos were randomly selected and transferred to a 96-well plate, each well containing 1 embryo and 0.2mL fish embryo culture medium/solvent solution. Positive group: 20 fish embryos were randomly selected and transferred to a 96-well plate, each well containing one fish embryo and phenylthiourea working solution. In the test substance 1 group, 60 fish embryos were randomly selected and transferred to a 96-well plate, each well containing one fish embryo and 0.2 mL of test substance 1. In the test substance 2 group, 80 fish embryos were randomly selected and transferred to a 96-well plate, each well containing one fish embryo and 0.2 mL of test substance 2. 60 fish embryos were randomly selected from the test substance 3 group, and transferred to a 96-well plate, each well containing one fish embryo and 0.2 mL of the test substance 3. Among them, the test substance 1 is composed of the modified oxidized resveratrol of Example 2 and the fish embryo culture fluid/solvent solution, and the test substance 1 includes 3 groups of experimental groups with different additions of modified resveratrol; The test substance 2 is composed of the unencapsulated oxidized resveratrol and the fish embryo culture fluid/solvent solution of the comparative example 1, and the test substance 2 includes 4 experimental groups with different addition amounts of uncoated resveratrol; The test substance 3 is composed of the oxidized resveratrol of Comparative Example 3 and fish embryo culture fluid/solvent solution, and the test substance 3 includes 3 experimental groups with different addition amounts of uncoated resveratrol.

Table 2 Zebrafish test inhibits melanin production test data

As can be seen from Table 2, the oxidized resveratrol of Example 2, the unwrapped oxidized resveratrol comparative example 1 and the oxidized resveratrol of comparative example 3 were subjected to the zebrafish test to inhibit melanin production, and the oxidized resveratrol of the test substance 1 group was used. The melanin inhibition rate of resveratrol is above 19%. When the content of oxidized resveratrol is 0.09%, the melanin inhibition rate reaches 49%, and both have whitening effect; No whitening effect. It can be clearly shown that the whitening effect of oxidized resveratrol encapsulated by vesicles made of non-ionic surfactants in the present application is better than that of unencapsulated oxidized resveratrol.

In summary, the oxidized resveratrol encapsulated by nanovesicle technology of the present invention improves the transdermal absorption of oxidized resveratrol through deformable vesicle technology, promotes its transmission in the skin, and increases its The effectiveness of transdermal absorption, thus enhancing its anti-oxidation, anti-glycation and whitening effects. At the same time, it solves the problem that the oxidized resveratrol is not easily dissolved in water, enhances its water solubility, improves the application of the oxidized resveratrol in preparations, and can increase its application value in the fields of food, medicine, health care and cosmetics. The preparation method of the oxidized resveratrol of the present invention is the oxidized resveratrol encapsulated by nanovesicles, and has the effect of reducing the exposure of the oxidized resveratrol to oxygen and thus improving the stability compared with the unencapsulated technology. The package of the present invention adopts high-pressure homogeneous circulation treatment, which is easy to operate and quick to prepare.

Those skilled in the art can make various other corresponding changes and deformations according to the above-described technical solutions and concepts, and all these changes and deformations should fall within the protection scope of the claims of the present invention.

Claims (10)

1. A modified oxidized resveratrol, characterized in that, the modified oxidized resveratrol is a vesicle structure, comprising the following raw material components in weight percent: 1-3% oxidized resveratrol, 5-10% water-soluble alcohol, 10-50% polyglyceryl nonionic surfactant, 1-5% oil-soluble ester, 32-83% water. 2. a kind of modified oxidized resveratrol according to claim 1, is characterized in that, comprises the raw material component of following percentage by weight: 1-3% oxidized resveratrol, 6-9% water-soluble alcohol, 20-40% polyglyceryl nonionic surfactant, 2-4% oil soluble ester, 45-70% water. 3. a kind of modified oxidized resveratrol according to claim 1, is characterized in that, described water-soluble alcohol is the composition of one or more than two in polyhydric alcohol, and described oil-soluble ester is sorbic acid Tanpalmitate. 4. A kind of modified oxidation resveratrol according to claim 1, is characterized in that, described polyglyceryl nonionic surfactant is polyglycerol-10 laurate and polyglycerol-10 dipalmitate One or a combination of both. 5. a kind of modified oxidation resveratrol according to claim 4 is characterized in that, polyglyceryl-10 laurate and polyglyceryl-10 dipalmitate in the polyglyceryl nonionic surfactant The mass ratio of is 1:(0.25-2). 6. the preparation method of a kind of modified oxidation resveratrol described in any one of claim 1-5 is characterized in that, comprises the following steps: S1. Dissolving oxidized resveratrol in water-soluble alcohol, adding polyglyceryl nonionic surfactant and oil-soluble ester, stirring and heating to obtain the first mixed solution; S2. Continue to add water to the first mixed solution prepared in step S1 for mixing and stirring to obtain a uniform emulsion; S3. Homogenize the emulsion obtained in step S2 to obtain the modified oxidized resveratrol. 7 . The method for preparing modified oxidized resveratrol according to claim 6 , wherein the temperature is controlled at 50-80° C. after adding polyglycerol nonionic surfactant in the step S1 . 8. a kind of preparation method of modified oxidized resveratrol according to claim 6 is characterized in that, pressure is 500bar-1500bar in the homogeneous treatment in described step S3, and number of cycles is 4-8 time, obtains The modified oxidized resveratrol. 9. The modified oxidized resveratrol prepared by the modified oxidized resveratrol described in any one of claims 1-5 or the modified oxidized resveratrol described in any one of claims 6-8 The application of resveratrol is characterized in that the modified oxidized resveratrol is used in anti-oxidation products and/or in products for inhibiting tyrosinase. 10. the application of modified oxidized resveratrol according to claim 9, is characterized in that, the mass ratio of described modified oxidized resveratrol in antioxidant product and/or inhibits tyrosinase product 0.1 to 8%.

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