CN1158113C - Method and apparatus for treating pathological conditions in tissue with incoherent radiation - Google Patents

Abstract

The present invention relates to a method for treating a tissue condition with incoherent radiation, wherein the periodic infrared irradiation is at 50-300mW/cm²The irradiation energy density of is considered to be 1-20 minutes every 1 or 2 days for the time of analgesia in tissue healing. Irradiation is performed on an area of the skin located above the organs responsible for disease processes caused by disturbances of metabolic, enzymatic and regenerative processes in the tissue. The illumination wavelength is 1-56 μm, linearly polarized and time modulated, which is selected according to the disease type. The inventive device receives an electronic control signal from an additional power supply of the control system (2) and adjusts the corresponding characteristic of the emitted light by means of the light emitter (3). The radiation source is calibrated in advance according to the density of the radiation flow. The optical transmitter (3) may be formed from a broadband semiconductor silicon light emitting diode having an incoherent infrared radiation wavelength of 1-56 μm and an ultra-thin p-n junction. The power supply (1) is connected along the plane of the p-n or n-p junction and ensures that a current is generated in the doped p-n or n-p junction. The control system (2) includes wires (c, d, e) connected to the source of the additional electric field, the wires being connected to the light emitting diode such that the electric field acts along the plane of the p-n junction and causes a reverse or direct migration across the p-n junction.

Description

Method and apparatus for treating pathological conditions in tissue with incoherent radiation

The invention relates to medicine and is used for the treatment of diseases accompanied by abnormal metabolism, weakened enzymatic processes, and abnormal regenerative function of affected tissues. This treatment method is used for the treatment of rheumatoid arthritis, diabetic vascular syndrome, gastric ulcer, duodenal ulcer, periodontal disease, periodontitis, burns, and the rehabilitation period after partial facial plastic surgery. other similar diseases.

The treatment of diabetic lower extremity vascular disease has the method of internal low-frequency infrared irradiation of blood (RU, Cl, 2049500, 27.12.95). A known method of diabetes treatment (RU, Cl, 2018329, 30.08.94) uses coherent radiation, directly irradiating the liquid components of the blood. The methods described above directly irradiate the blood internally. But they cannot affect physiological processes in tissue cells or their effects are mediated through several uncontrolled factors. In addition, the coherent infrared radiation used has a relatively low degree of penetration into the tissue, and the impact on the tissue structure is poor and relatively rigid.

A general warming device for body parts is known (GD, C, 4113803, 1994) using infrared rays which penetrate deeply into the human body. However, the therapeutic effect is obtained due to the increase in tissue temperature, which causes increased necrosis during tissue healing, tissue desiccation, promotes secondary inflammatory processes, and increases additional risks under the condition of vasodilation in histopathological changes.

A method for the treatment of skin wounds is known (RU, CI, 2032432, 10.04.95) based on the use of the effect produced by a monochromatic light beam pulsed in the red band. However, the pulse band is limited, the wavelength is 0.6 to 0.69 microns, and the radiation density is relatively low, equal to 5 to 10 milliwatts per square centimeter. The treatment is ineffective for all diseases with metabolic abnormalities.

It is known that a multi-wave medical laser (US, A, 5304167, 19.04.94) produces two kinds of rays, one of which is a pulsed energizing ray, and the other is a ray of visible light band, which acts on tissues at the same time. But this invention uses wave energy for surgery, not therapy.

A thermal stimulator is known (RU, CI, 2045969, 20.01.95) to act on tissue with infrared radiation in order to stimulate processes in the tissue, but thermal stimulation is used for this purpose.

A method of stimulating acupoints is known (RU, A, 93003767, 27.07.95) using infrared bands to stimulate processes in the body. Radiation has better penetration through the skin and uses 0.8 to 3 micron bands for irradiation, but its radiation source It is not on the organs that control the disease, but on the acupuncture points that affect the functions of the whole body, so the specific disease is not considered.

A known method of hemostasis in hemophilia (US, A, ^* 5161526, 10.11.1992, 1994) biostimulates affected muscles, joints with light beams. However, this method can only stop bleeding and increase the coagulation of blood, using the 5 to 1.1 micron wave band, has no therapeutic effect on the typical medical indicators of this type of disease.

A method of stimulating a biological object (RU, A, 93015098, 10.09.95) is known (RU, A, 93015098, 10.09.95) using modulated energy pulses, such as infrared modulated pulses, to optimize the energy system of the biological object, affecting locally the diseased organ. But this therapy does not suggest acting on the metabolic, regenerative and enzymatic processes in the tissue to treat the malfunction of the capillary blood circulation in the tissue, the malfunction of the vascular circulation, the malfunction of the lymphatic circulation, the slowing down of the blood flow, the functions in different tissue structures And undesirable phenomena such as slowing down of the oxidation-reduction process of anatomical morphological changes. The additionally produced effect is not optimal for the treatment of diseases that occur due to abnormalities in metabolic, regenerative and enzymatic processes in the tissues.

The closest approach to the therapy suggested below is a therapy for gastric and duodenal ulcers (RU, A, 94019587, 1996). This therapy involves directing infrared light through the skin to a topical part of the affected mucous membrane. The radiation density is 50 to 300 milliwatts per square centimeter, and the time is 1 to 20 minutes. However, the efficacy of this therapy is relatively low, because the skin is directly on the damaged mucous membrane, so the irradiation on it cannot achieve the most effective influence on metabolic, enzymatic and regenerative processes. The radiation waveband is 7 to 25 microns, and a large number of multiple irradiation treatments are required to obtain the effect. There are incidental complications, that is, tissue necrosis and edema, which reduce the therapeutic effect and weaken the level that affects the enzyme process, regeneration process, and metabolic process. This therapy does not penetrate enough radiation to activate the full potential of the tissue structure through its entire thickness. In addition, it is impossible to optimize and activate the processes in different damaged parts of different diseases, different tissues, different depths. Therefore, the risk of recurrence, complications, and slowing of the tissue healing process is increased, because of the adverse phenomena such as necrosis, scarring, and tissue edema.

A polarization-selective laser mirror (RU, Cl, 2034318, 27.04.95) is known that has multiple dielectric layers on the optical bottom layer to polarize the radiation, but this radiation comes from other radiation sources, so this cannot be used The machine adjusts the polarization parameters.

An optical radiation filtering method is known (SU, Cl, 1810868, 23.04.93) using linearly polarized light, which can cut long wavelengths and continuously adjust the limited transmission frequency, but cannot achieve the selected according to different objectives. Linear polarization of the wavelength of radiation.

A machine for treating skin deformation is known (US, A, 5320618, 14.06.94) emitting a pulsating beam, but the wavelength converter used does not respond to wavelength changes, so the optimum combination of wavelength and radiation pulsation degree cannot be achieved curative effect.

A high-energy light-emitting diode (LED) for phototherapy is known (PCT, WO, Al, 93/21842, 1993). This device and method for activating healing processes by light energy therapy uses high-energy light-emitting diodes in a certain light band. But the luminescence properties are displayed through complex feedback, so the device cannot be tuned to a specific disease type.

A polarizing grating is known (SU, Cl, 1781659, 15.12.1992) to generate polarized light with a relatively broad wavelength, with a wavelength of 1 to 100 micrometers. However, the polarizing grating cannot provide the parameter change required for specific disease treatment, because the wavelength cannot be selected within the preset light wavelength band. It is known that a bioenergy treatment machine (RU, Cl, 2043759, 20.09.95) has two kinds of generators, pulse and infrared, but it cannot achieve the effect on different diseases by directly controlling the light emission combined with radiation of specified wavelength and specific pulse parameters. best effect.

It is known that an irradiator (DE, Al, 4129192, 1994) uses frequency-selective translucent glass to filter different parts of the emitted light, that is, it first emits the spectrum with parasitic (harmful) components, and then uses a special instrument to filter the different parts of the emitted light. to adjust.

It is known that an irradiator (DE, Al, 4112275, 1994) separates the spectrum with a special spectrum separator with a dichroic layer, and can achieve a radiation spectrum with specified characteristics, but it cannot be separated according to different wavelengths, Polarization, modulation changes.

Known a kind of black therapy and instrument (US, A, 5282842, 01.02.94) with pulsed light induction. However, the radiation source is not included in the cycle of changing the pulse cycle according to the specific disease.

A phototherapy system is known (US, A, 5259380, 09.11.93) with light-emitting diodes emitting incoherent light in a narrow optical band with a central wavelength. Light-emitting diodes are in the group of diodes, which are controlled by a device that creates a potential difference, a device that generates a preset voltage. But the desired radiation characteristics are selected by the overall system, not by the nature of the radiators.

A known phototherapy instrument (RU, Cl, 2014854, 30.06.94) uses a pulsed cycle beam with adjusted intensity in the infrared light band to achieve a therapeutic effect. The radiation source of optical radiation is a metal halide lamp with a certain filling, which can control the intensity and spectral composition of the radiation, but it cannot achieve linear polarization, nor can it achieve modulation, polarization and wavelength optimization for specific diseases.

The closest engineering solution to the provided equipment is a phototherapy apparatus (RU, Cl, 2014854, 20.09.94, RU, A, 2033823, 20.09.95), which includes a radiation source of optical radiation, a control system. The radiation source can be calibrated according to the luminous flux density, and the different characteristics of the luminous flux can be controlled according to different treatment procedures. However, the characteristics of controlling the luminous flux are controlled by changing the position of the radiation source relative to the place where the disease occurs, or by changing the radiation source itself, and the best characteristic cannot be selected according to the specific disease.

From the point of view of technical substance, the closest approach to the proposed pathological tissue treatment is a treatment of inflammatory processes, uncomplicated ulcers of the gastric and duodenal mucosa (RU, Al, 4707945, 26.11.1991). It is assumed that the surface layer of the mucous membrane may be affected, and at the same time, the deeper part of the organ wall may be affected. There is a certain degree of radiation absorption between these layers. But changing the spectrum can only be achieved by changing the energy of the radiation source (eg, a halogen lamp) or by changing the distance between the distal end of the endoscope and the surface layer of the tissue being irradiated. However, this therapy cannot achieve the optimization of modulation, polarization and wavelength matching according to the specific disease.

The treatment of several different tissues such as muscles, joints, blood vessels, etc. needs to improve the therapeutic effect:

- metabolic disturbances, such as changes in the rate of transfer of trace elements from circulating blood to tissues, impaired absorption and release of blood oxygen and glucose-containing components during diabetic vascular syndrome;

- abnormal metabolism in the articular cartilage of rheumatoid arthritis;

- weakening of enzymatic processes, increased degree of metabolism in vascular diseases, burns, periodontal disease, gastric ulcer, duodenal ulcer,

-Gastric ulcer, duodenal ulcer, regeneration failure of damaged tissue (such as mucous membrane) during tissue healing after partial face plastic surgery, etc.

These diseases are accompanied by an inflammatory process, tissue edema, and tissue necrosis.

The main causes of the above process are as follows:

- malfunction of capillary blood circulation;

- vascular blood circulation failure;

- Lymphatic circulation failure;

- blood flow slows down;

- Redox processes slow down.

In the disease process described above, the above-mentioned process causes functional, anatomical and morphological changes in various tissue structures to occur.

The above process is characterized by changes in the blood circulation of the site, evaluated by the following parameters:

- degree of blood flow;

- stroke volume;

- Vascular wall resistance;

- vascular tone;

- rheographic index;

- vascular peripheral resistance index;

- organizational resilience;

- skin temperature;

- Time for tissue to heal and painful symptoms to disappear.

Irradiation of the damaged area with 1-56 micron broadband incoherent infrared radiation enhances the therapeutic effect, while simultaneously polarizing and modulating the emitted light, resulting in an optimal treatment of the particular disease caused by the above-mentioned disorders. Irradiation of incoherent infrared radiation must have an effective effect on the disease-controlling organs, ie act simultaneously on the entire tissue entity (surface and deep layers), optimally combining polarization and modulation effects of emitted light with a predetermined energy distribution. The optimal and maximum therapeutic effect for a particular disease is obtained by activating various processes in tissues using radiation with an optimal combination of wavelength and energy density.

The above beneficial effects are achieved by the method of the present invention for treating pathological tissue with incoherent radiation: irradiating the tissue with periodic infrared rays with a radiation density of 50-300 mW/cm ² for 1-20 minutes.

Irradiation is generally repeated once a day or two depending on the time required to suppress pain symptoms during the healing of pathological tissues.

The novelty of the method of the present invention lies in the irradiation of the skin site directly above the disease-controlling organ with infrared light in the 1-56 μm band combined linearly polarized and temporally modulated. The method uses a set of different wavelengths within a predetermined range, linearly polarizing and temporally modulating wavelengths specifically selected according to the nature of the disease. The radiation energy density is also selected according to the disease.

Therapeutic effects are produced by activating metabolic, enzymatic and regenerative processes in tissues.

All therapeutic effects are the result of improved blood circulation and accelerated regenerative processes in the tissues.

The method of the invention implies the functional contribution of the entire spectrum to the optimal combination of radiation parameters for a specific type of disease. Activation always occurs throughout the damaged tissue body due to accelerated metabolic, enzymatic and regenerative processes. Substantial improvement of medical indicators of various diseases is determined by the optimal combination of radiation parameters, allowing a shorter treatment period and maximal efficacy.

The inventive device for treating pathological tissue with incoherent radiation provides a solution to the problem of optimizing the therapeutic effect for a particular disease. This device comprises a power supply (1), a radiation source including a control system (2) and a radiator (3). When an electrical control signal is input from an additional power source of the control system, the device of the present invention provides radiation parameters that meet the requirements for maximum curative effect. The radiation source is pre-calibrated to provide the required radiant energy density.

The novelty of the device of the present invention lies in the use of ultra-thin "p-n" junction-based broadband semiconductor silicon light-emitting diodes (LEDs) with incoherent infrared radiation wavelengths of 1-56 microns as radiators. A power source (1) is connected along the plane (a) of the "p+n" or "n+p" junction to generate current in the doped "p+n" or "n+p" region. The control system (2) is equipped with wires (c, d, e) connected to additional electric field sources, which are connected to the LEDs so that the electric field is applied along the "p+n" plane (a), creating a reaction to the "p+n" junction Direct offset in direction. The control system (2) controls the spectral band of the emission wavelength, the degree of linear polarization and the frequency of temporal modulation. The control system (2) controls the LEDs by an electric field applied by an additional power source connected by wires (c, d, e). The value of this electric field is chosen according to the nature of the disease.

In order to obtain the desired result, the device cuts off a certain band in the broadband diode with a voltage applied to the "p-n" junction. When a control electric field of a predetermined value is applied, the emitted light is linearly polarized. Another additional control electric field modulates the emitted light to the desired frequency.

In this way, the device produces the desired combination of emitted light characteristics, ie a set of wavelengths in a predetermined range, the presence or absence of polarization, and modulated radiation to a predetermined frequency, such as 200 or 30 Hz. In this way, the optimization of the curative effect is achieved according to the nature of the disease.

Therefore, the device of the present invention realizes the above-mentioned method of treatment and produces an optimal therapeutic effect according to the nature of the disease.

The present invention thus makes it possible to obtain a maximum therapeutic effect according to the nature of the disease.

Brief description of the drawings

Figure 1 - Maximum and minimum curative effects of different types of radiation on medical indicators of different types of diseases;

Figure 2 - Comparative results of treatment of periodontal disease and periodontitis with radiation of A1, A, B, C, D characteristics;

Protocol I (V.I) - Flow Index (RI),

Protocol II (V.II) - Index of Peripheral Vascular Resistance (IRP),

Protocol III (V.III) - Index of Vascular Tone (IVT);

Figure 3a - Comparative results of radiation therapy for uncomplicated gastric and duodenal ulcers with characteristics A1, A, B, C, D:

Scenario I - Number of irradiations when the disease syndrome is suppressed (No-H),

Protocol II - number of irradiations when ulcers are inhibited (Nk-H);

Figure 3b - Comparative results of radiation therapy for chronic gastric and duodenal ulcers with characteristics A1, A, B, C, D:

Scenario I - Number of irradiations when pain syndrome is suppressed (Nc-X),

Protocol II - Number of irradiations when the ulcer is inhibited (Nk-X);

Figure 4 - Comparative results of radiation therapy for rheumatoid arthritis with characteristics A1, A, B, C, D:

Scheme - joint extension elasticity and flexion elasticity index;

Fig. 5-Comparative results of treatment with A1, A, B, C, and D characteristic radiation for diabetic vascular disease syndrome:

Scheme I-blood flow index (K) in limbs when the radiation energy density is 50 and 300mW/cm ² ;

Scenario II - skin temperature index (toσ) at the point of irradiation with 50 and 300 mW/ ^cm2 radiant energy density;

Scheme III - skin temperature index (tct) when the radiant energy density is 50 and 300mW/cm ² ;

Figure 6 - Comparison results of radiation therapy with A1, A, B, C, D characteristics after partial face plastic surgery:

Program I - stroke volume (PB);

Protocol II - Vascular Wall Resistance (VWR);

Protocol III - Index Value of Vascular Tone (IVT);

Fig. 7 - Comparative results of treatment of burns with A1, A, B, C, D characteristic radiation:

Scheme I - blood flow index (RI);

Protocol II - Index of Vascular Tone (IVT);

Protocol III - Peripheral Vascular Resistance Index (IRP);

Figure 8 - Schematic diagram of the device for treating pathological tissue with incoherent radiation.

Diseases caused by disturbances in metabolic, enzymatic, and regenerative processes result in functional, anatomical, and morphological changes in the structural elements of tissues that lead to the pathological processes of these tissues.

The following pathological processes are treated as follows:

- Periodontal disease and periodontitis cause the following pathological changes in tissues: tissue necrosis, disturbance of capillary circulation in the musculature of the gums, edema and inflammatory processes. Gingival features are: gingival bleeding, allergies, hygiene index (IH), blood flow index (RI), vascular peripheral resistance index (IPR), vascular tension index (IVT) increase. Radiation with a wavelength ranging from 1 to 56 μm, polarized and modulated at 30 to 200 Hz produces the best therapeutic effect (see Figure 1, Figure 2). The therapeutic effect was characterized by stable RI-v.I, IPR-v.II and IVT-v.III (see Figure 2) with values close to normal. Even at the minimal therapeutic effect produced by unpolarized and unmodulated radiation from 1–56 μm, values of RI, IPR, and IVT were closer to normal than those produced by radiation with wavelengths from 7 to 25 μm (see Figure 2, A1). This effect comes from the stimulation of blood circulation and the enrichment of oxygen in the blood;

- Gastric and duodenal ulcers cause the following pathological changes in the tissues: inflammation of the mucosa, scar formation as a result of ulcer healing, desiccation of the epithelium leading to necrosis of the mucosal tissue, secondary inflammation due to an unfavorable combination of applied irradiation parameters ( slows tissue healing). Thus, for example, mucosal surface epithelium heals better after short-term irradiation with higher frequency modulation (200 Hz) without increasing energy density (see Fig. 1, Fig. 3a, Fig. 3b). Healing of the epithelium in the inner mucosal layer is more effective when irradiated with increased light energy for a longer period of time. Such treatment is characterized by deep penetration of energy into the mucosal tissue (see Fig. 1, Fig. 3a, Fig. 3b), high level of radiation of the tissue and better energy distribution in the tissue. The efficiency of the method was evaluated by the number of irradiations required for pain relief and ulcer control. Observed when irradiated with radiation with a wavelength of 1-56 μm polarized (see Figure 3a, vI, v.IIB) at an energy density of 50 mW/ ^cm2 and with a wavelength of 1-56 μm polarized and modulated at a frequency of 200 Hz The best therapeutic effect to an uncomplicated ulcer (see Fig. 1, vI, v.IIC, Fig. 3a). The best therapeutic effect of chronic ulcers was observed when using polarized radiation with a wavelength of 1-56 μm and modulated at a frequency of 30 Hz. Judging by the above description, the minimal therapeutic effect in all cases was better than that produced by irradiation at 7-25 μm requiring at least 3 to 4 irradiation sessions for pain relief and ulcer control. Preventing tissue overheating during irradiation can enhance therapeutic efficacy through optimal distribution of energy on the epithelial tissue.

- Rheumatoid arthritis causes local (mainly venous) circulatory disturbances, hypoxia of joint elements, metabolic disturbances in the articular cartilage, aseptic and spontaneous aseptic necrosis of the joint head. The condition of the joint is characterized by a) its stretch elasticity in the extreme extension position (B), the normal joint position (E), its stretching elasticity in the zero degree angle position (C) relative to stretch and b) its stretch elasticity in the extreme flexion position ( A), Flexural elasticity at the normal joint position (F), at a position (D) corresponding to a zero degree angle after flexion. Optimal therapeutic effect was characterized by minimum residual force in flexion and extension and maximum flexion and extension angle (Figure 1). The best therapeutic effect is produced by irradiating the joints with light with a wavelength of 1-56 μm and polarized modulation at a frequency of 200 and 30 Hz with a minimum energy density of 50 mW/cm ² . The minimum therapeutic effect is 3 to 4 irradiation times earlier than the irradiation with 7-25 μm (Fig. 4.A1) to produce analgesia and normalize part of the capillary pressure;

- Diabetic vascular syndrome causes a decrease in the stabilization of trace elements in tissues, an attenuation of the absorption of oxygen and oxygenated components of the blood, the production of hormones and attenuation of metabolic functions. Localization and inhibition of these effects by irradiation is characterized by an increase in skin temperature at the site of irradiation and on the foot, depending on cell membrane permeability affecting energy exchange between cells, their enzymatic and regenerative activity and hormone production Sexual changes. The best therapeutic effect is produced by polarized radiation of wavelength 1-56 μm with an energy density of 50 mW/cm ² or 300 mW/cm ² ( FIG. 1 , FIG. 5 ). The minimal therapeutic effect yielded results that exceeded the therapeutic efficiency with radiation of 1-25 μm wavelength (Fig. 5, A1). These results were confirmed by the fact that the temperature dropped to almost normal values and by questioning the patients confirming a more rapid reduction of pain, muscle tone and limitation of motion in the joints and muscles. These effects are produced by strengthening blood circulation. This suggests a clear stimulation of the level of tissue exchange, especially peroxide oxidation, as the volume of blood circulation per minute correlates with the levels of glucose and immunoreactive insulin in blood glucose before treatment.

- The rehabilitation process after partial facial plastic surgery causes the following highly undesirable pathological changes: mechanical damage to tissues due to surgery, aseptic inflammation of tissues, edema of soft tissues, formation of scarring of connected tissues. These changes were assessed by the degree of change in the regional circulation, manifested as a decrease in stroke volume (PB) and vessel wall resistance (VWR), which are indicators of blood microcirculation. These changes were also characterized by a lower index of vascular tone (IVT) and the presence or absence of edema. The best therapeutic effect is produced by polarized radiation with a wavelength of 1-56 μm modulated at a frequency of 200 or 30 Hz depending on the indication ( FIG. 1 , FIG. 6 , C, D). The minimal therapeutic effect brings the above indicators closer to normal values than irradiating the patient with a wavelength of 1-25 μm due to better microcirculation and regeneration of skin cells. One case of positive therapeutic kinetics has been observed, with a reduction in pain and edema after just one irradiation. The wound healed once after a complete treatment without suppuration or separation of sutures.

- Burns cause inflammatory processes in the wound, vascular disorders due to trichangiectasia and slowing of blood circulation, edema and hypertrophic granulation of tissues, necrosis. These processes are characterized by increases in blood flow index (RI), vascular tone index (IVT) and peripheral resistance index (IRP). The optimal therapeutic effect is produced by polarized radiation of wavelength 1-56 μm modulated at a frequency of 200 or 30 Hz according to the specific indication ( FIG. 1 , FIG. 7 ). The minimal therapeutic effect produces results that are closer to normal than those produced by radiation of wavelength 1-25 μm (Fig. 7, A1). Macroscopic observation showed faster wound healing, regression of edema, and less deformed scar size at the edges of skin tissue grafts.

The method of treatment of the present invention was tested in a group of 60 patients. There are age criteria for the formation of these groups. The control group consisted of either primary uncomplicated or chronic patients, regardless of gender, divided into five groups according to age (from 17 to 68 years). All control parameters were measured during recovery or when pain ceased. Organs responsible for the disease process are irradiated for 20 minutes every 1 or 2 days, depending on the patient's condition. Measurements were performed after 10 irradiations. The number of treatments required to achieve this effect was recorded after pain resolution or ulcer control. Therapeutic irradiation is performed at the site of the skin directly over the organ or joint responsible for the disease process. The surface area on which the light is irradiated is chosen to provide three controlled fluence values, namely: 50, 150 and 300 mW/cm ² . Control measurements were performed before and after treatment. Patients in the control group were irradiated with radiation having a wavelength of 7-25 μm, and the same parameters characterizing the efficacy of the treatment were recorded. The light source of the radiator is corrected for the selection of a suitable distance between the LED and the surface of the organ responsible for the disease process. This is done by varying degrees of IR absorption values according to specific wavelength combinations within the 1-56 μm band.

Semiconductor LEDs emit in the far-infrared spectrum by forming a relevant bandgap in an electron- or hole-attenuating gas density generated in a heavily doped quantum-sized doping profile (publications on this subject are known, for example: Н .Т.т, е. .клячкин, е.и.чайкина "индуцированное инфракрасное излучение кремниисильнолегированными квантоворазмерными диффузионными диффузионными профилями профилями профилями профилями профилями т т т т т т distributed in the infrared radiation produced in silicon" вып.8, М: Наука, 1993г.). The degree of disorder in the relative bandgap size and its distribution within the doped region of the "p-n" junction controls the radiative properties.

The device offers a combination of different radiation characteristics. Measurements of all medical controls were performed after irradiation.

The same combination of radiation parameters was used for patients in all groups. They are as follows:

A1-7-25μm radiation;

A-1-56μm radiation;

B - radiation in the 1-56 μm band with linear polarization;

C - radiation from 1-56 μm with linear polarization and modulated at 200 Hz;

D - radiation from 1-56 μm with linear polarization and modulated at 30 Hz;

The method of treatment of pathological tissue with incoherent radiation can be carried out as follows:

Example 1. A group of patients aged 30 to 57 years, diagnosed with periodontal disease or periodontitis, was irradiated with linearly polarized light at a wavelength of 1 to 56 microns and modulated to 200 or 30 Hz. After five irradiations, the main medical indexes of the disease were normalized, the deviation from the normal state was not more than one percent, and the gingival edema and hemorrhage disappeared. Visually observe and check the blood flow curve (refer to Figure 2).

Example 2. A group of patients aged 27 to 66, diagnosed with gastric and duodenal ulcers, was irradiated with linearly polarized light of 1 to 56 micron wavelength and modulated to 200 or 30 Hz. After three exposures, the main medical indices normalized. The pain symptoms disappeared after the first treatment, and the ulcer also relieved after three to five treatments. There is no secondary inflammatory process, tissue edema. The course of the treatment is monitored endoscopically and by interviewing the patient (cf. Figs. 3a, 3b).

Example 3. A group of patients aged 35 to 68, diagnosed with rheumatoid arthritis, was irradiated with linearly polarized light at a wavelength of 1 to 56 microns and modulated to 200 or 30 Hz. After ten times of irradiation, the elasticity of joint tissue, tissue viscosity, and degree of internal friction in the joint all returned to normal, pain symptoms disappeared, and part of the blood pressure in the capillaries also recovered. Use subcutaneous polarographic analysis and dynamic diagnostic methods to check the treatment process (refer to Figure 4).

Example 4. A group of patients aged 17 to 53 years, diagnosed with diabetic angiopathy syndrome, was irradiated with linearly polarized light of wavelength 1 to 56 microns and modulated to 200 or 30 Hz. After seven times of irradiation, the medical index of extremity blood flow has improved, which is close to the normal state, and the deviation from the optimal index is within 2%. The temperature of the irradiated local skin and foot skin decreased, which was equal to the normal value. Joint and muscle pain levels are reduced, and muscle tone is normalized. Joint flexibility is enhanced. Checked with blood flow curve, calculated with Tishenko method. Subjective indices were checked by questioning the patient (see Figure 5).

Example 5. A group of patients aged 18 to 48, in remission after partial face plastic surgery, was irradiated with radiation of 1 to 56 micron wavelength linearly polarized and modulated to 200 or 30 Hz. After ten times of irradiation, the medical indexes of stroke volume, vascular wall resistance, and vascular tension normalized, and the soft tissue edema dissipated. Use the arterial blood flow tracing method of the face to check (refer to Figure 6).

Example 6. A group of patients aged 16 to 40 years, diagnosed with first and second degree face and neck burns, were irradiated with linearly polarized light with a wavelength of 1 to 56 microns and modulated to 200 or 30 Hz. After ten irradiations, the following medical indexes were normalized: blood flow index, vascular tension index, and vascular peripheral resistance index. The appearance of tissue border necrosis, hypertrophic granulation, and astringent scars in autografted skin blocks was reduced (see Figure 7). Check by visual observation and blood flow tracing on healthy skin 1 to 3 mm away from the burn.

This method of treatment is best practiced with the operation of the apparatus of the present invention in the following manner:

Once the constant current power supply (1) is connected to the device, the current starts to flow through the p+ (n+) region of the radiator (3). The (p-n) junction emits light in the 7-25 μm spectral range. A voltage developed from one of the additional power sources is applied through terminal (b) to the control system (2), thereby extending the spectral range to 1-56 μm. A voltage applied between the ends (c) in the plane of the "p-n" junction converts the unpolarized radiation of the "p-n" junction into linearly polarized light while preserving all other radiation characteristics. A voltage applied between the terminals (d) converts the unmodulated (continuous) radiation of the "p-n" junction into 200Hz modulated radiation while maintaining all other radiation characteristics. A voltage applied across the ends (e) converts the unmodulated (continuous) radiation of the "p-n" junction into modulated radiation at 30 Hz, while maintaining all other radiation characteristics.

Therefore, the radiation emitted by the device of the present invention provides an optimal treatment solution for a class of diseases caused by dysregulation of metabolic, enzymatic and regenerative processes.

Claims (3)

1. an enforcement is with the equipment of the method for noncoherent radiation treatment pathological tissue, it comprises power supply (1), the radiation source that comprises control system (2) and irradiator (3), irradiator provides required radiant energy dfensity through pre-calibration, it is characterized in that using the broadband semiconductor silicon LED of tying based on ultra-thin " p-n " (LED) as irradiator (3) with 1-56 micron incoherent infrared radiation wavelength, power supply (1) links along the plane (a) of " p+n " or " n+p " knot, in adulterated " p+n " or " n+p " district, to produce electric current, control system (2) is equipped with the lead (c that links the additional electrical field source, d, e), they and LED link the plane (a) that makes along " p+n " knot and apply electric field, tie oppositely directly skew of generation, the wave spectrum scope of described control system (2) control wavelength of transmitted light at " p+n ", its linear polarization degree and time modulating frequency.

2. according to the equipment of claim 1, it is characterized in that control system (2) by by lead (c, d, e) the electric field controls LED that banded additional supply applied, the value of described electric field is selected according to the character of disease.

3. according to the equipment of claim 1, wherein said method radiant energy density is 50-300mW/cm ²Infra-red radiation periodically shone 1-20 minute, wherein said radiation is in the skin site that is located immediately on the disease attribution organ, described disease causes by metabolism, enzyme and regenerative process imbalance in the tissue, and described irradiation is to modulate in conjunction with linear polarization and time with the radiation of 1-56 mu m waveband to carry out.

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