CN115300603A - Composition for treating rheumatic immune diseases, preparation method and application - Google Patents

Abstract

The invention relates to a composition for treating rheumatic immune diseases, a preparation method and application thereof, wherein the composition comprises the following raw material components: the feed comprises agaric powder, saffron powder, galangal extract, celery seed powder, mangosteen extract, sunflower disc small molecular peptide, gastrodia elata extract, durian extract, cherry extract, galangal extract, dendrobium officinale extract, turmeric extract, chicory extract, jerusalem artichoke extract, grape seed powder, wild papaya extract, sea buckthorn powder, pineapple extract, sealwort extract, olive extract, inulin, vitamin C, phytosterol and L-arabinose. The composition of the invention is used for treating various rheumatic immune diseases including gouty arthritis, rheumatoid arthritis, rheumatic arthritis, ankylosing spondylitis, dermatomyositis and osteoarthritis, has remarkable curative effect, no toxic or side effect, natural and safe raw materials.

Description

Composition, preparation method and application for rheumatic immune diseases

technical field

The invention belongs to the technical field of health care products, and in particular relates to a composition for rheumatic immune diseases, a preparation method and an application.

Background technique

Rheumatic immune diseases refer to a series of diseases in internal medicine, mainly including rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis, overlap syndrome, vasculitis, and ankylosing spondylitis, reactive Arthritis, psoriatic arthritis, undifferentiated spondyloarthropathy, osteoarthritis, gouty arthritis, reactive arthritis, etc. These diseases are still medical treatment problems, and conservative treatment is the main method, which is generally difficult to cure. And the existing treatment methods are mainly western medicine treatment methods, including taking non-steroidal anti-inflammatory painkillers to reduce inflammation and pain relief, and taking immunosuppressants, glucocorticoids, etc. to alleviate the progress of the disease. These treatment methods have certain therapeutic effects, but side effects Obviously, many people have difficulty adhering to the full course of treatment. In recent years, some new treatment methods such as biological agents of immune response and cytokine regulators, gene therapy, stem cell transplantation, and plasma replacement are expensive, and long-term side effects are not yet clear, and their clinical application is limited. Other traditional Chinese medicine treatment methods The effect is very little, and only some famous Chinese medicine practitioners can achieve certain results in a small area under the premise of dialectical treatment, and there are certain limitations in the promotion of treatment.

Contents of the invention

The object of the present invention is to aim at the deficiencies of the prior art, and provide a new treatment plan for rheumatic immune diseases with remarkable curative effect, no toxic and side effects, natural and safe raw materials.

For realizing above-mentioned object of the present invention, the present invention adopts following technical scheme:

A composition for rheumatic immune diseases, including the following raw materials: Monarch medicine: fungus powder, safflower powder, galangal extract, celery seed powder, mangosteen extract, small molecular peptide of sunflower disc, Gastrodia elata extract Extract, Durian Extract, Cherry Extract, Galangal Extract, Dendrobium officinale Extract; Herbs: Turmeric Extract, Chicory Extract, Jerusalem Artichoke Extract, Grape Seed Powder, Wild Papaya Extract. Adjuvant: seabuckthorn powder, pineapple extract, sealwort extract, green olive extract, inulin. Drugs: vitamin C, phytosterols, L-arabinose. Preferably, in parts by weight, the following raw material components are included: 7-10 parts of fungus powder, 7-10 parts of saffron powder, 3-5 parts of galangal extract, 3-5 parts of celery seed powder, mangosteen extract 3-5 parts, 6-9 parts of sunflower disc small molecule peptide, 6-9 parts of Gastrodia elata extract, 5-8 parts of durian extract, 3-5 parts of cherry extract, 3-5 parts of southern ginger extract, Dendrobium officinale 3-5 parts of extract, 3-5 parts of turmeric extract, 3-5 parts of chicory extract, 3-5 parts of Jerusalem artichoke extract, 5-7 parts of grape seed powder, 5-7 parts of wild papaya extract, sea buckthorn powder 5-8 parts, 3-5 parts of pineapple extract, 3-5 parts of sealwort extract, 3-5 parts of green olive extract, 1-2 parts of inulin, 1-2 parts of vitamin C, 1-2 parts of phytosterol, 1-2 parts of L-arabinose.

Composition provided by the invention, each raw material effect is specifically as follows:

Fungus powder: retains all the nutrients of fungus, rich in protein, cellulose, calcium, iron, phosphorus, carotene, fungus polysaccharides, vitamins B1, B2 and vitamin C, and the unique plant gum of fungus, etc. The active ingredient is conducive to the rapid absorption and intake of various nutrients by the human body. It is a natural and convenient standardized health food. Experiments have proved that after the fungus is made into powder, the absorption rate can reach about 98%, which is more than 2 times higher than direct consumption without crushing. Fungus powder has the effect of anti-platelet aggregation and reducing blood coagulation, can reduce blood clots, prevent thrombosis, and has better prevention and health care effects on coronary heart disease and other cardiovascular and cerebrovascular diseases as well as arteriosclerosis. In addition, it also has the functions of cleaning the digestive tract, clearing the stomach and intestines, replenishing iron and blood, promoting gastrointestinal peristalsis, preventing constipation, and dissolving stones.

Saffron powder: Contains crocin, crocetin, crocetin, crocetin, volatile oil, vitamin B2, glucose, amino acids, saponins, etc. Crocin has strong anti-cancer activity; crocins have a strong blood-activating effect, can significantly increase coronary blood flow, and promote blood circulation; proteoglycans can quickly activate protein kinase C and NF-kappaB, Promote the activity of macrophages, thereby having immune regulation and anti-invasion functions.

Galangal extract: It is prepared from the dried rhizome of Alpinia officinarum Hance, a plant of Zingiberaceae. It mainly contains diphenylheptanes, volatile oils, flavonoids, glycosides, phenylpropanoids, and sterols. It has strong anti-oxidation, hypoglycemic, anti-cancer, promoting permeability, anti-ulcer, anti-emetic, anti-diarrhea, analgesic, anti-inflammatory, anti-coagulation, anti-thrombotic and other unique pharmacological effects. Galangal is a tropical perennial ginger, which is a plant resource with both food and medicine. Galangal is hot in nature and pungent in taste. It has the effects of warming the stomach, dispelling cold, dispelling wind, promoting qi, and relieving pain. It can treat indigestion, stomach cold, vomiting and diarrhea, and dysentery. It is a commonly used traditional Chinese medicine.

Celery seed powder: the main ingredients are flavonoids, volatile oils, linolenic acid, apigenin, cymelide, eucalyptol and trace elements, etc. It has the functions of protecting blood vessels and assisting in regulating blood lipids and blood pressure. From the perspective of traditional Chinese medicine, celery seed powder diuretic, swelling, and qi can not only lower blood pressure but also diuretic and swelling, and can also prevent the occurrence of many common diseases such as arthritis, ascites, and nephritis.

Mangosteen extract: the active ingredient extracted from the mangosteen of Garcinia genus Garcinia, containing xanthones, phenolic acids, anthocyanins, polymerized tannins and other ingredients. It has good antioxidant activity, antibacterial, anti-inflammatory and anti-allergic, immune-enhancing and anti-tumor effects.

Sunflower disc small molecule peptide: It is a sunflower disc small molecule peptide extracted from sunflower disc sponge body by using bio-enzymatic hydrolysis technology and sunflower disc as raw material. The molecular weight is generally lower than 1000 Da, because of its small molecular weight, it has superior characteristics that proteins and amino acids do not have in terms of efficacy, digestion and absorption. It mainly has the following functions: 1. Regulate the acid-base balance of the human body, reduce acid, dissolve tophi crystals, restore the metabolism and detoxification function of the kidney itself, normalize the metabolism and detoxification of the kidney, and restore the kidney's own immunity. All uric acid is discharged, high uric acid is no longer produced, and the pain of gout patients is reduced; 2. As a transportation tool for sunflower plate alkaloids and flavonoids, various substances required by the human body are adsorbed on it, and then used as a carrier to transport them to In each cell, tissue and organ of the human body, let these substances be absorbed by the body together with small molecular peptides; 3. Expand and soften blood vessels, reduce serum cholesterol levels, and purify blood; 4. Strengthen the spleen and appetizers, promote the secretion of gastric juice, Improve indigestion; promote blood circulation, treat bronchial asthma, influenza.

Gastrodia elata extract: Contains gastrodin, gastrodin, gastrodioside, parishin, vanillyl alcohol, β2 sterol, p-hydroxybenzaldehyde, citric acid, succinic acid, etc. Pharmacological effects include: Pinggan Xifeng Zhijing. For headache, dizziness, numbness of limbs, hemiplegia, convulsions in children, epileptic convulsions, and tetanus.

Durian extract: It is extracted from the fruit of durian, a plant of Kapokaceae. It is rich in amino acids. In addition to tryptophan, it also contains 7 kinds of essential amino acids for human body. Among them, the content of glutamic acid is particularly high. Glutamic acid is a nucleic acid and nucleotide. , an important precursor of amino sugar and protein, participate in their synthesis and metabolism, can improve the body's immunity, and improve the body's ability to adapt to stress. Chinese medicine believes that durian is a nourishing and beneficial fruit for invigorating the spleen, nourishing qi, tonifying the kidney and strengthening yang, and warming the body; it is hot in nature, can promote blood circulation and dispel cold, and relieve menstrual pain, especially suitable for women who suffer from dysmenorrhea; it can also improve abdominal coldness and promote body temperature It is an ideal tonic for those with cold physique.

Cherry extract: active substance extracted from acerola cherry, rich in vitamin C, also contains vitamin A, B1, B2, E, P, niacin, anti-aging factor (SOD), calcium, iron, zinc, Nutrients such as potassium and protein. It is an excellent natural antioxidant, which can promote blood circulation, help the excretion of uric acid, relieve discomfort caused by gout and arthritis, and has the effect of analgesic and anti-inflammatory.

Galangal extract: It is prepared from the dried rhizome of Alpinia galanga (Linn.) Willd, also known as reed ginger, and contains reed gingerin, kaempferin, kaempferin and volatile oil. The main components of the oil are 1,8-cineole and methyl cinnamate. Galangal is pungent and slightly warm in nature, warms the stomach and dispels cold, relieves indigestion and relieves pain. It has the effects of warming the spleen and stomach, dispelling wind and cold, promoting qi and relieving pain. For epigastric cold pain, stomach cold vomiting, belching and acid regurgitation etc.

Dendrobium officinale extract: It is prepared from the stem of Dendrobium officinale, a perennial epiphytic herb of Orchidaceae. It contains polysaccharides from Dendrobium officinale, which can promote the production of migration inhibitory factors for lymphocytes in the immune system. Under experimental conditions, it can also eliminate immunosuppressants In addition to the side effects of cyclophosphamide, clinical experiments have also proved that Dendrobium polysaccharides have a very significant effect on regulating the body's immunity. In addition, it also has the functions of anti-cell mutation, clearing aging dead cells in the body, and stabilizing the physiological state of the body.

Turmeric extract: derived from the dry rhizome of Curcumalonga L., a plant in the ginger family. Contains volatile oil, and the main components in the oil are curcumone, aromatic curcumone, gingerene, etc.; the yellow substance is curcumin, and contains demethoxycurcumin, bisdemethoxycurcumin, dihydrocurcumin, etc. Dispelling blood and promoting qi circulation, promoting menstrual flow and relieving pain. For stagnation of Qi in blood, chest and hypochondria, abdominal pain due to amenorrhea, swelling and pain from falls, rheumatism pain.

Chicory Extract: The source of extraction is the aerial parts and roots of the Compositae plant Chicory (CichoriumintybusL.). Containing chicory polysaccharide and cichoric acid, chicory polysaccharide has multiple functions such as lowering blood sugar, lowering blood fat, anti-oxidation, anti-tumor, lowering blood pressure, improving immunity and delaying aging. Chichoric acid can be quickly distributed to various tissues, combined with plasma proteins, quickly transported to various tissues and organs throughout the body, and can pass through the blood-brain barrier. It can enhance immunity and anti-inflammatory effects, increase lipid metabolism, promote uric acid decomposition, improve Glucose metabolism and other functions.

Jerusalem artichoke extract: Jerusalem artichoke is a perennial herbaceous plant, the source of its extraction is its tubers, which are rich in fructose polymers such as starch and inulin. It can effectively proliferate bifidobacteria in the human body, reduce blood lipids, improve lipid metabolism, improve human immune function, diuretic and dampness.

Grape seed powder: refers to the grape polyphenols extracted from grape seeds, also known as anthocyanins (OPC), which have a strong antioxidant effect, can remove toxic free radicals in the human body, and protect cell tissues from oxidative damage caused by free radicals . Some medical studies have shown that preparations containing proanthocyanidins have anti-aging and anti-cancer effects, and are beneficial to the health of the cardiovascular system. In addition, animal experiments also show that grape seed powder has anti-prostate cancer, anti-liver tumor effects, and can also resist damage to the nervous system. Population studies have found that grape seed powder can lower cholesterol and improve blood circulation in some people. Other studies have shown that grape seeds are good for skin health and can keep skin elastic.

Wild Papaya Extract: It is a reddish-brown powdery extract product of the fruit of Chaenomeles speciosa (Sweet) Nakai, a Rosaceae plant. Contains malic acid, tartaric acid, citric acid, saponins and flavonoids, fresh fruit contains catalase and seeds contain hydrocyanic acid. Functions and indications: Calming the liver and relaxing the tendons, dispelling dampness and harmonizing the stomach. For damp arthralgia spasm, soreness and pain of waist and knee joints, vomiting, diarrhea and tendons turning, beriberi edema.

Sea buckthorn powder: enters the lung meridian, has the effect of moistening the lungs, and can be used to treat cough, phlegm, asthma, bronchitis, bronchial asthma and other symptoms caused by lung dryness. It is rich in seabuckthorn oil, which can relieve fatigue and enhance the body's immunity. Seabuckthorn is rich in vitamin C, fruit acid and various trace elements. Eating in moderation can supplement the vitamins needed by the body and improve the body's resistance.

Pineapple extract: The source of extraction is the fruit of pineapple, a perennial herbaceous fruit tree plant of the genus Pineapple, which is rich in fructose, glucose, protein, amino acids, organic acids, vitamins and other ingredients. Sweet, slightly sour, slightly cold in nature, it has the effects of clearing heat and relieving heat, promoting body fluid and quenching thirst, and diuresis. .

Polygonatum extract: brown yellow powdery substance extracted from the rhizome of Polygonatum. Flat in nature, sweet in taste, it belongs to the spleen, lung, and kidney meridians, and its functions and indications are: invigorating qi and nourishing yin, invigorating the spleen, moistening the lungs, and benefiting the kidney. For weakness of the spleen and stomach, fatigue and fatigue, dry mouth and lack of food, dry cough due to lung deficiency, insufficient essence and blood, internal heat and thirst.

Green olive extract: green olive, also called green fruit, is the fruit of the olive plant olive, containing protein, fat, carbohydrates, dietary fiber, carotene, retinol, vitamin B1, vitamin B2, niacin, vitamin C, calcium , iron, phosphorus, magnesium, zinc, selenium and other ingredients, sweet and sour, flat in nature, clearing away heat and detoxification, relieving throat and reducing phlegm, promoting body fluid and quenching thirst, appetizing and lowering qi, eliminating troubles and sobering up, and preventing heart disease, gastric ulcer and protecting gallbladder function.

Inulin: absorbs intestinal fat to form a fat-fiber complex and excretes it with feces, thereby reducing blood lipid levels; it will not be hydrolyzed into simple sugars in the upper part of the intestinal tract, so it will not increase blood sugar levels and insulin levels; can greatly improve The absorption of calcium ions, magnesium ions, zinc ions, copper ions, iron ions and other minerals can promote physical development and help increase the bone mineral content and density of the body; enhance gastrointestinal peristalsis, improve gastrointestinal function, increase digestion and appetite, Improve the body's immunity.

Vitamin C: For the formation of antibodies and collagen, tissue repair (including certain redox effects), metabolism of phenylalanine, tyrosine, and folic acid, utilization of iron and carbohydrates, synthesis of fat and protein, maintenance of immune function, Hydroxylated serotonin is necessary to maintain the integrity of blood vessels and promote the absorption of non-heme iron. It is also a high-efficiency antioxidant and is used to reduce the oxidative stress of ascorbate peroxidase sch. In addition, there are many important biosynthetic processes Vitamin C is also needed to participate in the function of blood.

Phytosterol: It is a functional component that exists in a free state or in a state combined with fatty acids and sugars, and is widely present in the cell membranes of various plants such as vegetables and fruits. It is divided into three categories: 4-methylsterol, 4-methylsterol and 4,4'-dimethylsterol. 4-methylsterol mainly includes β-sitosterol, stigmasterol, campesterol and brassicasterol, etc. . It has the effect of scavenging hydroxyl radicals and inhibiting the production of oxygen anions. It is a mild free radical scavenger and can maintain the stability of cell membranes. Phytosterols have obvious effects on anti-inflammation, anti-infection, and inhibition of bacteria and fungal reproduction. The body can play a better anti-inflammatory effect by absorbing phytosterols.

L-arabinose: L-arabinose is a non-caloric sugar with unique functions. Even if it is consumed for a long time, it will not bring adverse effects on the body. It is non-toxic to humans and animals, and helps to improve the micro-ecological environment of the human body. It can clean the digestive tract and enhance digestive function, while diluting and accelerating the removal of carcinogens and toxic substances in food, protecting the fragile digestive tract and preventing colon cancer. Regulate the balance of the gastrointestinal tract, and at the same time comprehensively regulate the digestive system and regulate the balance of human endocrine. L-arabinose can affect the activity of hydrolytic disaccharidase in the human intestine, block the absorption, transformation and metabolism of sucrose by the human body, and inhibit the excessive absorption of sucrose by the human body, thereby achieving the effect of lowering blood sugar.

The composition of the present invention is preferably a powder, and the preparation method is as follows: respectively take 5 kinds of raw materials of fungus, saffron, celery seed, grape seed and seabuckthorn, and after drying and pulverizing respectively, obtain fungus powder, saffron powder and celery seed powder, grape seed powder, seabuckthorn powder; mix the said raw material powders with the remaining raw materials evenly to obtain. The drying is preferably low-temperature freeze-drying, and the crushing is preferably crushed to pass through a 40-60 mesh sieve.

The composition of the present invention can be used to prepare food and health products for regulating rheumatic immune diseases or medicine for treating rheumatic immune diseases. products and their application in the preparation of drugs for the treatment of rheumatic immune diseases, including but not limited to gouty arthritis, rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, dermatomyositis, Osteoarthritis.

The beneficial effects of the present invention are:

The composition for rheumatic immune diseases provided by the present invention is obtained by including fungus powder, saffron powder, galangal extract, celery seed powder, mangosteen extract, sunflower disc small molecular peptide, Gastrodia elata extract, durian extract Extract, Cherry Extract, Galangal Extract, Dendrobium officinale Extract, Turmeric Extract, Chicory Extract, Jerusalem Artichoke Extract, Grape Seed Powder, Wild Papaya Extract, Sea Buckthorn Powder, Pineapple Extract, Polygonatum Extract, Green Olive A variety of medicinal and edible components including extracts and inulin, combined with vitamin C, phytosterols, and L-arabinose, are used in combination and supplemented with appropriate weight ratios, so that the effects of each component are complementary and have a strong It has the functions of promoting blood circulation, promoting blood flow, and dissipating blood stasis, which can effectively improve the poor nutrition supply of tendons, ligaments, synovial bursa, and fascia caused by poor blood circulation caused by wind, cold and damp. The composition of the invention can induce and activate the anti-oxidation system of the body, remove excessive free radicals in the body, protect cells from free radical damage, improve the metabolic level, and improve the metabolic disorder caused by wind-cold-damp pathogen invasion. In addition, it also has a strong anti-inflammatory and analgesic effect, which can significantly relieve local redness, swelling and pain symptoms, reduce the pain of patients, and can play a two-way immune regulation effect on the proliferation or secretion of immune cells, and enhance the immune function of patients with rheumatic immune diseases. disease resistance, and then improve the treatment effect of the disease from the source. The composition of the invention has remarkable curative effect, no toxic and side effects, and the raw materials are natural and safe.

Detailed ways

In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other implementations obtained by persons of ordinary skill in the art without making creative efforts fall within the protection scope of the present invention. The raw materials in the following examples were all obtained from the market, among which, galangal extract, sunflower disc small molecular peptide, Gastrodia elata extract, chicory extract, and durian extract were purchased from Snowte; mangosteen extract was purchased from Shaanxi Jiahe Biology ; Cherry extract was purchased from Xiannong Biotechnology Co., Ltd.; Ginger extract and turmeric extract were purchased from Lanzhou Waterles; Dendrobium officinale extract was purchased from Bolin Biotechnology; Company; wild papaya extract was purchased from Shaanxi Senyuan Biotechnology Co., Ltd.; pineapple extract was purchased from Xi'an Shouhe Biotechnology Co., Ltd.; sealwort extract and green olive extract were purchased from Kepler Biotechnology; inulin was purchased from Shanxi Jinheng Chemical Co., Ltd.; and 1 serving represents 1g.

Example 1

A powder for rheumatic immune diseases, made of the following raw material components:

7 parts of fungus powder, 10 parts of saffron powder, 3 parts of galangal extract, 5 parts of celery seed powder, 3 parts of mangosteen extract, 9 parts of small molecular peptide of sunflower disc, 9 parts of Gastrodia elata extract, 5 parts of durian extract , 5 parts of cherry extract, 3 parts of galangal extract, 5 parts of Dendrobium officinale extract, 3 parts of turmeric extract, 5 parts of chicory extract, 3 parts of Jerusalem artichoke extract, 7 parts of grape seed powder, 5 parts of wild papaya extract 8 parts of seabuckthorn powder, 3 parts of pineapple extract, 5 parts of sealwort extract, 3 parts of green olive extract, 2 parts of inulin, 1 part of vitamin C, 2 parts of phytosterol, 1 part of L-arabinose.

The preparation method is as follows: respectively take 5 kinds of raw materials of fungus, saffron, celery seed, grape seed and seabuckthorn, freeze-dry them respectively, and crush them to pass through a 40-mesh sieve to obtain fine powders of each raw material; mix the fine powders of raw materials with The rest of the raw materials are mixed evenly, that is.

Example 2

A powder for rheumatic immune diseases, made of the following raw material components:

10 parts of fungus powder, 7 parts of saffron powder, 5 parts of galangal extract, 3 parts of celery seed powder, 5 parts of mangosteen extract, 6 parts of small molecular peptide of sunflower disc, 6 parts of Gastrodia elata extract, 8 parts of durian extract , 3 parts of cherry extract, 5 parts of galangal extract, 3 parts of Dendrobium officinale extract, 5 parts of turmeric extract, 3 parts of chicory extract, 5 parts of Jerusalem artichoke extract, 5 parts of grape seed powder, 7 parts of wild papaya extract 5 parts of sea buckthorn powder, 5 parts of pineapple extract, 3 parts of sealwort extract, 5 parts of green olive extract, 1 part of inulin, 2 parts of vitamin C, 1 part of phytosterol, 2 parts of L-arabinose.

The preparation method is as follows: respectively take 5 kinds of raw materials of fungus, saffron, celery seed, grape seed and seabuckthorn, freeze-dry them respectively, and crush them to pass through a 40-mesh sieve to obtain fine powders of each raw material; mix the fine powders of raw materials with The rest of the raw materials are mixed evenly, that is.

Example 3

A powder for rheumatic immune diseases, made of the following raw material components:

8 parts of fungus powder, 8 parts of saffron powder, 4 parts of galangal extract, 4 parts of celery seed powder, 4 parts of mangosteen extract, 8 parts of small molecular peptide of sunflower disc, 8 parts of Gastrodia elata extract, 6 parts of durian extract , 4 parts of cherry extract, 4 parts of galangal extract, 4 parts of Dendrobium officinale extract, 4 parts of turmeric extract, 4 parts of chicory extract, 4 parts of Jerusalem artichoke extract, 6 parts of grape seed powder, 6 parts of wild papaya extract 6 parts of seabuckthorn powder, 4 parts of pineapple extract, 4 parts of sealwort extract, 4 parts of green olive extract, 2 parts of inulin, 2 parts of vitamin C, 1 part of phytosterol, and 1 part of L-arabinose.

The preparation method is as follows: respectively take 5 kinds of raw materials of fungus, saffron, celery seed, grape seed and seabuckthorn, freeze-dry them respectively, and crush them to pass through a 60-mesh sieve to obtain fine powders of each raw material; mix the fine powders of raw materials with The rest of the raw materials are mixed evenly, that is.

Randomly selected 509 subjects with rheumatic immune diseases, including 130 cases of gouty arthritis, 85 cases of rheumatoid arthritis, 110 cases of rheumatoid arthritis, 66 cases of ankylosing spondylitis, 30 cases of dermatomyositis, 88 cases of arthritis, all diseases were confirmed by hospital inspection, all subjects were aged 12-75 years old, 226 males and 283 females. All the subjects were randomly divided into two groups, 230 cases in the control group, and 279 cases in the treatment group, wherein, the control group was given conventional western medicine treatment, and the treatment group was given the powder of Example 3 of the present invention on the basis of the control group, orally, in the morning and evening after meals 1 time each time, 8g each time, the treatment effect statistics are shown in the following table.

Table 1 Treatment effect statistics

Among them: early stage: after taking for 2 months; mid-term: after taking for 4 months; late stage: after taking for 6 months;

Healed: the clinical discomfort symptoms disappeared; improved: the clinical discomfort symptoms were relieved; invalid: the clinical discomfort symptoms did not change.

The results showed that in the treatment of various diseases including gouty arthritis, rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, dermatomyositis and osteoarthritis, the recovery rate and improvement rate of the treatment group All are significantly higher than the control group, indicating that the composition of the present invention can obviously improve the therapeutic effect of rheumatic immune diseases, and the therapeutic effect is definite and remarkable.

Other experiments show that: the composition of the present invention can significantly enhance the differentiation of Th2 cells in T lymphocytes, secrete IL-4, 4, 10, 13, etc., inhibit monocytes, promote the release of anti-inflammatory cytokines, and play a role in inhibiting inflammation. function, and inhibit the clearance of blood uric acid, xanthine oxidase, oxidative stress-related factors, rheumatoid factor, rheumatoid factor, C-reactive protein in plasma, and control the activity of superoxide dismutase and glutathione peroxidase , reduce malondialdehyde, carbon monoxide content, reduce oxidative damage.

The above is only a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Anyone skilled in the art can easily think of changes or substitutions within the technical scope disclosed in the present invention. Should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be determined by the protection scope of the claims.

Claims (9)

1. A composition for rheumatic immune diseases, characterized in that, comprising the following raw material components: Fungus powder, saffron powder, galangal extract, celery seed powder, mangosteen extract, sunflower small molecule peptide, gastrodia elata extract, durian extract, cherry extract, galangal extract, dendrobium officinale extract, turmeric Extract, Chicory Extract, Jerusalem Artichoke Extract, Grape Seed Powder, Wild Papaya Extract, Sea Buckthorn Powder, Pineapple Extract, Polygonatum Extract, Green Olive Extract, Inulin, Vitamin C, Phytosterols, L-arabinose. 2. The composition for rheumatic immune diseases according to claim 1, characterized in that, in parts by weight, comprising the following raw material components: 7-10 parts of fungus powder, 7-10 parts of saffron powder, 3-5 parts of galangal extract, 3-5 parts of celery seed powder, 3-5 parts of mangosteen extract, 6-9 parts of sunflower small molecule peptide , 6-9 parts of Gastrodia elata extract, 5-8 parts of durian extract, 3-5 parts of cherry extract, 3-5 parts of southern ginger extract, 3-5 parts of Dendrobium officinale extract, 3-5 parts of turmeric extract , 3-5 parts of chicory extract, 3-5 parts of Jerusalem artichoke extract, 5-7 parts of grape seed powder, 5-7 parts of wild papaya extract, 5-8 parts of seabuckthorn powder, 3-5 parts of pineapple extract, Polygonatum 3-5 parts of extract, 3-5 parts of green olive extract, 1-2 parts of inulin, 1-2 parts of vitamin C, 1-2 parts of phytosterol, 1-2 parts of L-arabinose. 3. The composition for rheumatic immune diseases according to claim 1, characterized in that the composition is a powder. 4. The preparation method of the powder according to claim 3, characterized in that, the specific steps are: respectively take 5 kinds of raw materials of fungus, saffron, celery seed, grape seed and seabuckthorn, and after drying and pulverizing respectively, obtain fungus powder , saffron powder, celery seed powder, grape seed powder, seabuckthorn powder; mixing each of the raw material powders with the remaining raw materials evenly to obtain the product. 5. The preparation method of powder according to claim 4, characterized in that, the drying is low-temperature freeze-drying. 6 . The preparation method of the powder according to claim 4 , wherein the pulverizing is pulverizing until passing through a 40-60 mesh sieve. 7 . 7. The application of the composition for rheumatic immune diseases according to any one of claims 1-3 in the preparation of food or health care products for regulating rheumatic immune diseases. 8. The use of the composition for rheumatic immune diseases according to any one of claims 1-3 in the preparation of medicines for treating rheumatic immune diseases. 9. The application according to claim 7 or 8, characterized in that, the rheumatic immune disease is gouty arthritis, rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, dermatomyositis or osteoarthritis. arthritis.