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CN114901642A - 一种稠环化合物及其应用 - Google Patents

一种稠环化合物及其应用 Download PDF

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Publication number
CN114901642A
CN114901642A CN202080091546.6A CN202080091546A CN114901642A CN 114901642 A CN114901642 A CN 114901642A CN 202080091546 A CN202080091546 A CN 202080091546A CN 114901642 A CN114901642 A CN 114901642A
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independently
halogen
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CN114901642B (zh
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娄军
陈永凯
张轶涵
郭晓丹
钱丽娜
柳力
彭微
容飞
王朝东
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Wuhan LL Science and Technology Development Co Ltd
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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/40—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/20—Oxygen atoms
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    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

本发明公开了一种稠环化合物及其应用。本发明公开了一种如式I所示的稠环化合物、其药学上可接受的盐、其立体异构体、其互变异构体、其同位素化合物、其晶型、其氮氧化物、其溶剂合物或其药学上可接受的盐的溶剂合物。本发明的稠环化合物具有高的P2X4拮抗活性，且具有较好的选择性，毒性较低、代谢稳定性较好。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN202080091546.6A 2019-12-30 2020-12-29 一种稠环化合物及其应用 Active CN114901642B (zh)

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CN2019113965674 2019-12-30
CN201911396567 2019-12-30
PCT/CN2020/140689 WO2021136238A1 (zh) 2019-12-30 2020-12-29 一种稠环化合物及其应用

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CN114901642A true CN114901642A (zh) 2022-08-12
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US (1) US20230118751A1 (zh)
EP (1) EP4079724B1 (zh)
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CA (1) CA3163440A1 (zh)
WO (1) WO2021136238A1 (zh)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
IT202100025124A1 (it) * 2021-09-30 2023-03-30 Univ Degli Studi Di Firenze Medicamento per uso nel prevenire o trattare il dolore nocicettivo e/o viscerale
WO2024255861A1 (zh) * 2023-06-16 2024-12-19 武汉朗来科技发展有限公司 一种p2x4抑制剂固体分散体及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101300235A (zh) * 2005-09-01 2008-11-05 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物
CN107848974A (zh) * 2015-06-10 2018-03-27 拜耳制药股份公司 芳族磺酰胺衍生物
WO2018104305A1 (en) * 2016-12-09 2018-06-14 Bayer Pharma Aktiengesellschaft Field of application of the invention
WO2018104307A1 (en) * 2016-12-09 2018-06-14 Bayer Pharma Aktiengesellschaft Aromatic sulfonamide derivatives and their use as anatagon i sts or negative allosteric modulators of p2x4
CN109415321A (zh) * 2016-05-03 2019-03-01 拜耳制药股份公司 芳族磺酰胺衍生物
CN114845996A (zh) * 2019-11-29 2022-08-02 武汉朗来科技发展有限公司 一种含苯环的化合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2008113836A (ru) * 2005-09-09 2009-10-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Бициклические производные в качестве модуляторов потенциалозависимых ионных каналов

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101300235A (zh) * 2005-09-01 2008-11-05 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物
CN107848974A (zh) * 2015-06-10 2018-03-27 拜耳制药股份公司 芳族磺酰胺衍生物
CN109415321A (zh) * 2016-05-03 2019-03-01 拜耳制药股份公司 芳族磺酰胺衍生物
WO2018104305A1 (en) * 2016-12-09 2018-06-14 Bayer Pharma Aktiengesellschaft Field of application of the invention
WO2018104307A1 (en) * 2016-12-09 2018-06-14 Bayer Pharma Aktiengesellschaft Aromatic sulfonamide derivatives and their use as anatagon i sts or negative allosteric modulators of p2x4
CN114845996A (zh) * 2019-11-29 2022-08-02 武汉朗来科技发展有限公司 一种含苯环的化合物及其应用

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CA3163440A1 (en) 2021-07-08
US20230118751A1 (en) 2023-04-20
CN114901642B (zh) 2024-02-23
EP4079724A4 (en) 2023-11-22
EP4079724A1 (en) 2022-10-26
EP4079724B1 (en) 2025-11-12
WO2021136238A1 (zh) 2021-07-08

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