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CN114786685A - 一种基于线粒体的药物递送系统及其用途 - Google Patents

一种基于线粒体的药物递送系统及其用途 Download PDF

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Publication number
CN114786685A
CN114786685A CN202080001203.6A CN202080001203A CN114786685A CN 114786685 A CN114786685 A CN 114786685A CN 202080001203 A CN202080001203 A CN 202080001203A CN 114786685 A CN114786685 A CN 114786685A
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mitochondria
delivery system
drug delivery
diseases
drug
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CN114786685B (zh
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唐凌峰
吴忆华
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

一种基于线粒体的药物递送系统，所述药物递送系统包括：线粒体，和负载于所述线粒体的药物，其中所述药物是通过非自由扩散的方式负载于所述线粒体的。该药物递送系统能够有效地将蛋白质类、核酸类或其他药物递送到细胞内，能够用于治疗单基因遗传病、多基因遗传病或其他疾病，也可用于健康个体以实现延缓衰老、增强机体功能或者预防疾病等目的。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080001203.6A 2019-07-09 2020-07-08 一种基于线粒体的药物递送系统及其用途 Active CN114786685B (zh)

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US201962871710P 2019-07-09 2019-07-09
US62/871710 2019-07-09
PCT/CN2020/100825 WO2021004477A1 (zh) 2019-07-09 2020-07-08 一种基于线粒体的药物递送系统及其用途

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112999357A (zh) * 2021-03-03 2021-06-22 中国药科大学 一种外源线粒体载体、复合物及其制备方法和应用
CN113122497B (zh) * 2021-04-26 2023-08-11 重庆理工大学 工程化线粒体及其制备方法
CN119486767A (zh) * 2022-06-10 2025-02-18 赛尔维股份公司 作为靶向递送平台的线粒体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100111911A1 (en) * 2007-02-16 2010-05-06 John Guy Mitochondrial nucleic acid delivery systems
EP2992892A1 (en) * 2014-09-05 2016-03-09 Universität zu Köln Fusion protein for use in the treatment of mitochondrial diseases
WO2017124037A1 (en) * 2016-01-15 2017-07-20 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109661468B (zh) * 2016-05-06 2024-01-02 新加坡国立大学 重组核酸的线粒体递送
CN109415363B (zh) * 2016-05-18 2021-07-20 罗格斯，新泽西州立大学 用于治疗代谢疾病和癌症的新的线粒体解偶联剂
US11278569B2 (en) * 2016-11-14 2022-03-22 Paean Biotechnology Inc. Natural killer cell containing exogenous mitochondrium and pharmaceutical composition comprising same
US20190276852A1 (en) * 2016-11-14 2019-09-12 Paean Biotechnology Inc Method for delivering exogenous mitochondria into cells
WO2018101708A1 (ko) * 2016-11-30 2018-06-07 차의과학대학교 산학협력단 미토콘드리아를 포함하는 약학 조성물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100111911A1 (en) * 2007-02-16 2010-05-06 John Guy Mitochondrial nucleic acid delivery systems
EP2992892A1 (en) * 2014-09-05 2016-03-09 Universität zu Köln Fusion protein for use in the treatment of mitochondrial diseases
WO2017124037A1 (en) * 2016-01-15 2017-07-20 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
THOMAS G. MCWILLIAMS等: ""mito-QC illuminates mitophagy and mitochondrial architecture in vivo"", 《J. CELL BIOL.》, vol. 214, no. 3, pages 333 *
左伋等, 复旦大学出版社 *

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CN114786685B (zh) 2025-05-06

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