CN114681603A - Therapeutic HPV vaccine based on chimpanzee adenovirus vector, preparation method and application thereof - Google Patents

Abstract

The invention discloses a therapeutic HPV vaccine based on a chimpanzee adenovirus vector, a preparation method and application thereof. The therapeutic HPV vaccine is obtained by packaging and processing the HPV virus vaccine vector plasmid to obtain an immunogenic HPV recombinant adenovirus A virus vaccine, wherein the HPV virus vaccine vector is a replication-deficient chimpanzee adenovirus vector. The invention constructs the HPV therapeutic vaccine by using the replication-defective chimpanzee adenovirus vector, overcomes the influence of the pre-existing immunity of the human-derived adenovirus vector in the human body on the efficacy of the vaccine, and is expected to obtain simple preparation, low cost, good safety, and no need for Adjuvanted vaccine products. The present invention has good immunogenicity and anti-tumor efficacy, and a single intramuscular immunization can induce a high level of antigen-specific T cell response and anti-tumor efficacy in mice; it is expected to be reflected in human clinical trials Better humoral and cellular immunotherapy effects.

Description

Therapeutic HPV vaccine based on chimpanzee adenovirus vector, its preparation method and application

This application is a divisional application, and its parent case is an invention patent application with an application date of November 26, 2020 and an application number of CN202011349388.8.

technical field

The invention relates to the technical field of therapeutic vaccines, in particular to a therapeutic HPV vaccine based on a chimpanzee adenovirus vector, a preparation method and application thereof.

Background technique

High-risk human papillomavirus (HPV) infection is the cause of nearly all invasive cervical cancers and several other malignancies such as anal and genitalia. In China, high-risk HPV types 16 and 18 (HPV16/18) tested positive in more than 70% of cervical intraepithelial neoplasia stage 2/3 (CIN2/3) and cervical squamous cell carcinoma (SCC) samples (Chen, W., Molijn, A., Enqi, W., et al. (2016). The variable clinicopathological categories and role of human papillomavirus in cervical adenocarcinoma: Ahospital based nation-wide multi-center retrospective study across China. Int J Cancer.139( 12), 2687-2697. Chen, W., Zhang, X., Molijn, A., et al. (2009). Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18. Cancer Causes Control. 20(9), 1705-13.). After high-risk HPV infects cervical epithelial stromal cells, its viral genome has a high probability of integrating into the host cell genome, resulting in the high expression of HPV oncogene E6/E7, which can be induced by inducing the deletion of host pRB and p53 proteins. tumorigenesis (Moody, C.A., and Laimins, L.A. (2010). Human papillomavirus oncoproteins: paths to transformation. Nat RevCancer. 10(8), 550-60.). The high detection rate of HPV E6/E7 proteins in tumor samples and the conservation of their own sequences provide an excellent tumor-specific targeting antigen for the development of therapeutic vaccines (Mirabello L, Y.M., Yu K, Clifford GM). , Xiao Y, Zhu B, Cullen M, Boland JF, Wentzensen N, Nelson CW, Raine-Bennett T, Chen Z, Bass S, Song L, Yang Q, Steinberg M, Burdett L, Dean M, RobersonD, Mitchell J, Lorey T, Franceschi S, Castle PE, Walker J, Zuna R, Kreimer AR, Beachler DC, Hildesheim A, Gonzalez P, Porras C, Burk RD, Schiffman M. (2017). HPV16E7 Genetic Conservation Is Critical to Carcinogenesis. Cell. 170 (6), 1164-1174.).

At present, the vast majority of adenovirus vaccine products focus on preventive vaccines, especially in the field of infectious diseases. In the field of therapeutic vaccines for cervical cancer caused by HPV infection, although the research on adenovirus vaccines has a history of nearly two decades, most of them are still in the preclinical research stage. Therefore, the search for a new HPV therapeutic vaccine is imminent.

SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to provide a therapeutic HPV vaccine based on a chimpanzee adenovirus vector, a preparation method and an application thereof, aiming at the deficiencies in the above-mentioned prior art.

In order to solve the above-mentioned technical problems, the technical solution adopted in the present invention is as follows: one aspect of the present invention is to provide a therapeutic HPV vaccine, wherein the therapeutic HPV vaccine is obtained by packaging and processing the HPV virus vaccine vector plasmid to obtain immune The original HPV recombinant adenovirus vaccine, wherein the HPV virus vaccine vector is a replication-defective chimpanzee adenovirus vector.

In a preferred example, the replication-deficient chimpanzee adenovirus vector is a chimpanzee adenovirus replication-defective type 63 or type 3 adenovirus.

In a preferred embodiment, the therapeutic HPV vaccine encodes E6 and E7 proteins of HPV virus.

In a preferred embodiment, the HPV virus includes HPV type 16 and HPV type 18.

In a preferred example, the HPV16-E6, HPV16-E7, HPV18-E6 and HPV18-E7 sequences are the consensus sequences of all amino acid sequences obtained in the NCBI database as of June 2017. Specifically, as of June 2017, 767 HPV16 E6 proteins, 691 HPV16 E7 proteins, 358 HPV18 E6 proteins, and 109 HPV18 E7 protein amino acid sequences were obtained from the NCBI database. , the consensus conserved sequences of the four proteins were obtained. In order to avoid the possible safety problems caused by the introduction of wild-type oncogenic proteins E6 and E7 into the vaccine components, the present invention is based on the obtained antigenic protein consensus sequence conserved, the p53, pRB binding sites of E6 and E7 proteins and Several amino acid mutations were introduced at other key sites, making it free from the risk of cellular transformation and greatly enhancing the safety of the antigen (Cassetti et al., 2004; Gan et al., 2014; Martinez-Zapien et al., 2016; Nguyenet al., 2002; Nomine et al., 2006; Peng et al., 2014; Polakova et al., 2010; Ristriani et al., 2009; Yan et al., 2009).

Wherein, the amino acid sequence of HPV 16-E6 protein is SEQ ID NO: 1, the amino acid sequence of HPV 16-E7 protein is SEQ ID NO: 2, the amino acid sequence of HPV 18-E6 protein is SEQ ID NO: 3, and the amino acid sequence of HPV 18-E7 protein is SEQ ID NO: 3. The amino acid sequence of the antigen is SEQ ID NO:4.

In a preferred example, the amino acid sequence of the E6 or E7 protein of HPV type 16 and the amino acid sequence of the E6 or E7 protein of HPV type 18 are connected by a linker sequence P2A, and the sequence of P2A is SEQ ID NO: 5;

The amino acid sequences of E6 and E7 proteins of HPV 16 are connected by a linker sequence F2A, and the amino acid sequences of E6 and E7 proteins of HPV 18 are connected by a linker sequence F2A, and the sequence of F2A is SEQ ID NO:6.

In a preferred example, the four antigenic proteins HPV 16-E6, HPV 16-E7, HPV 18-E6 and HPV 18-E7 are connected by connecting sequences P2A and F2A to form a fusion protein HPV 16/18-E6/E7 ; The amino acid sequence of the HPV 16/18-E6/E7 is SEQ ID NO: 7, and the designed DNA sequence of the sequence after codon optimization is SEQ ID NO: 8.

In a preferred example, in the genome sequence of the replication-deficient chimpanzee adenovirus vector, an open reading frame sequence containing the HPV 16/18-E6/E7 gene is inserted between the ΔE1 sites MluI and EcoRI.

In a further preferred example, the replication-deficient chimpanzee adenovirus vector is chimpanzee adenovirus replication-deficient 63, and the chimpanzee adenovirus replication-deficient 63 vector plasmid is a wild-type chimpanzee adenovirus 63 genome sequence in E1 After the transformation (deletion and replacement) of the , E3 and E4 regions, insert the transfer vector plasmid to construct the recombinant vector plasmid, and the plasmid sequence is shown in SEQ ID NO: 13. The genome sequence of replication-defective chimpanzee adenovirus type 63 contained in the plasmid is shown in SEQ ID NO: 14.

In a further preferred example, the replication-deficient chimpanzee adenovirus vector is chimpanzee adenovirus replication-deficient 63, and the chimpanzee adenovirus replication-deficient 63 vector plasmid refers to the recombinant chimpanzee adenovirus 63 contained in the vector plasmid The open reading frame of the HPV16/18-E6/E7 gene initiated by the CMV promoter was inserted between the sites MluI and EcoRI in the ΔE1 (E1 modified region) of the type genome, thereby obtaining a recombinant adenovirus vector plasmid pChAd63-HPV; this plasmid The sequence is shown in SEQ ID NO: 15; the recombinant adenovirus type 63 ChAd63-HPV that can express the HPV16/18-E6/E7 antigen contained in the plasmid has the genome sequence shown in SEQ ID NO: 16.

In a preferred embodiment, the therapeutic HPV vaccine further encodes IL-12 or GM-CSF cytokine.

In a preferred example, in the genome sequence of the replication-deficient chimpanzee adenovirus vector, an open reading frame sequence containing the murine GM-CSF or IL-12 gene is inserted between the ΔE3 sites HpaI and Pad. The amino acid sequence of the murine cytokine GM-CSF is derived from UniProt (#P01587), as shown in SEQ ID NO: 9, and the designed DNA sequence after codon optimization is shown in SEQ ID NO: 10. The amino acid sequence of murine cytokine IL-12 is derived from UniProt (p35, #P43431; p40, #P43432), and the two subunits are connected by a linker sequence F2A, as shown in SEQ ID NO: 11, which is codon-optimized The designed DNA sequence is shown in SEQ ID NO:12.

In a further preferred example, the replication-deficient chimpanzee adenovirus vector is chimpanzee adenovirus replication-deficient type 63, and the recombinant plasmid refers to the recombinant chimpanzee adenovirus type 63 genome sequence contained in the vector plasmid pChAd63-HPV , and further insert an open reading frame containing the murine cytokine GM-CSF between the ΔE3 (E3 modified region) sites HpaI and PacI, which is the murine cytokine GM-CSF expression frame initiated by the CB promoter sequence. The recombinant adenovirus vector plasmid pChAd63-HPV-mu-GMCSF, which can simultaneously express the antigen HPV16/18-E6/E7 and the murine cytokine GM-CSF, was obtained by gene synthesis. The plasmid sequence is shown in SEQ ID NO:17. The genome sequence of the recombinant adenovirus type 63 ChAd63-HPV-GMCSF, which can simultaneously express the antigen HPV16/18-E6/E7 and the murine cytokine GM-CSF, contained in the plasmid is shown in SEQ ID NO: 18.

In another further preferred example, the replication-deficient chimpanzee adenovirus vector is chimpanzee adenovirus replication-deficient type 63, and the recombinant plasmid refers to the recombinant chimpanzee adenovirus type 63 genome sequence contained in the vector plasmid pChAd63-HPV , an open reading frame containing murine cytokine IL-12 is further inserted between ΔE3 (E3 modified region) sites HpaI and PacI, which refers to the expression of murine cytokine IL-12 initiated by the CB promoter box sequence. The recombinant adenovirus vector plasmid pChAd63-HPV-mu-IL12, which can express both the antigen HPV16/18-E6/E7 and the murine cytokine IL-12, was obtained by gene synthesis. The plasmid sequence is shown in SEQ ID NO:19. The genome sequence of the recombinant adenovirus type 63 ChAd63-HPV-mu-IL12, which can simultaneously express the antigen HPV16/18-E6/E7 and the murine cytokine IL-12, contained in the plasmid is shown in SEQ ID NO: 20.

The present invention chooses to insert murine cytokine gene sequences because the present invention is a proof-of-concept completed in mice. It should be understood that if the present invention is applied to other hosts, such as rabbits, non-human primates, humans, etc., the cytokine needs to be replaced with the cytokine gene sequence derived from the corresponding host.

Another aspect of the present invention also provides a preparation method of the above-mentioned therapeutic HPV vaccine, comprising the following steps:

1) Select chimpanzee adenovirus replication-deficient type 63 or type 3 adenovirus as model virus vectors, select E6 and E7 of HPV 16 and HPV 18 as model antigens;

2) Insert the nucleotide sequences encoding the E6 and E7 antigen proteins of HPV 16 and HPV 18 alone or together with the nucleotide sequence of the murine cytokine IL-12/GM-CSF into the model virus vector plasmid to construct a recombinant plasmid;

3) After the recombinant plasmid was digested and linearized, it was transfected into adenovirus packaging cells, and 80% of the cells were cultured to have obvious cytopathic effects;

4) Collect the cells, break the cells by repeated freezing and thawing, and collect the supernatant by centrifugation;

5) Infect the adenovirus packaging cells with the supernatant, and cultivate until the cells change from adherence to suspension;

6) Repeatedly expand the culture to a certain volume according to steps 3) and 4), collect the cells, centrifuge after crushing, and take the supernatant;

7) Purify the recombinant adenovirus by taking the supernatant to obtain a virus solution, which is the therapeutic HPV vaccine stock solution.

In a preferred example, the packaging cell is an adherent cell line or a suspension cell line that can support the proliferation of replication-deficient adenoviruses.

Another aspect of the present invention also provides the use of the therapeutic HPV vaccine as described above, for preparing a medicine or a kit for preventing or treating HPV-related diseases.

The adenoviral packaging cells refer to the adherent HEK293 cell line.

The beneficial effects of the present invention are:

1. The present invention develops a HPV therapeutic vaccine based on a chimpanzee adenovirus vector for the first time. Since the chimpanzee adenovirus is not prevalent in the population, the vaccine of the present invention will not be affected by pre-existing anti-human adenovirus neutralizing antibodies in the human body;

2. The adenovirus vector vaccine in the present invention is simple to prepare, has good safety, does not need to add exogenous adjuvants, and can be embedded with endogenous adjuvants (such as human cytokines GMCSF and IL12), and adopts immune approaches such as muscle immunization or oral immunization , with good market competitiveness;

3. The novel HPV therapeutic vaccine of the present invention is not only original, but also has good immunogenicity and anti-tumor efficacy. A single intramuscular immunization can induce a high level of antigen-specific T cell responses in mice and Anti-tumor efficacy; it is expected to demonstrate better humoral and cellular immunotherapy effects in human clinical trials.

4. The present invention constructs a HPV therapeutic vaccine with a replication-defective chimpanzee adenovirus vector, overcomes the influence of pre-existing immunity existing in the human body on the efficacy of the vaccine by the human-derived adenovirus vector, and is expected to obtain simple preparation, low cost and good safety. , No need to add adjuvant, a vaccine product with a wide range of application prospects.

Description of drawings

Figure 1: The design map of the recombinant chimpanzee adenovirus vector plasmid pChAd63-HPV; A. The schematic diagram shows that the plasmid pChAd63-HPV is constructed by replacing the vector EGFP reporter gene with the target antigen gene sequence, B. The sequence map of the plasmid pChAd63-HPV, the map shows that the plasmid vector is The transformed pNEB193 plasmid is marked, and the key restriction sites in the vector and the position of the target antigen gene are marked.

Figure 2: Schematic diagram of the foreign gene inserted into the recombinant adenovirus and its upstream promoter based on the chimpanzee adenovirus ChAd63 vector platform; pCMV: cytomegalovirus immediate-early promoter. pCB: chickenβ-actin promoter.

Figure 3: Detection of the expression results of the target gene in recombinant adenovirus for HPV therapeutic vaccine; A. Western-blot detection of recombinant adenovirus ChAd63-HPV infected HEK293 cells (1×10 ⁵ vps/cell) for 18 hours, the target antigen HPV16/cell 18-E6/E7 protein expression, β-actin protein as a positive control; BCELISA detected recombinant adenovirus-infected HEK293 cells (1×10 ³ vps/cell) for 72 hours, the murine cytokine IL-12 in the cell culture supernatant or GM-CSF concentration, error bars show mean and standard deviation.

Figure 4: The results of the recombinant adenovirus ChAd63-HPV inducing antigen-specific T cell immune responses in mice. The ordinate of the left graph in Figure 4 is IFN-γ. C57BL/6 and BALB/c mice were intramuscularly inoculated with 8 × 10 ¹⁰ vps of ChAd63-HPV once, and the same dose of ChAd63-EGFP was used as a negative control; spleen lymphocytes were isolated two weeks later, and mouse IFN-γ/IL-2 Fluorospot test. The stimulus is a synthetic mixed polypeptide covering HPV16/18-E6/E7 protein (18 peptides, overlapping 10 amino acid residues between two adjacent peptides); A. IFN-γ spot forming unit (SFU) ; B. Number of IL-2 spots. All spot counts are values after subtraction of blank stimulus control; error bars show mean and standard deviation, P values are two-tailed t-test, *: p<0.05; ***: p<0.001.

Figure 5: The results of the integration of cytokine GM-CSF to enhance the HPV antigen-specific T cell immune response; C57BL/6 mice were intramuscularly injected with 8 × 10 ¹⁰ vps recombinant adenovirus HPV vaccine once, and the same dose of ChAd63-EGFP was used as a negative control; Two weeks later, the spleen lymphocytes were isolated, and the mouse IFN-γ/IL-2 Fluorospot test was performed; the stimulus was a synthetic mixed polypeptide covering HPV16/18-E6/E7 proteins; A. The number of IFN-γ spots, B. IL- 2 Number of spots; error bars show mean and standard deviation, P values are two-tailed T-test, *: p<0.05; **: p<0.01. ***: p<0.001.

Figure 6: The results of integrating cytokine GM-CSF to enhance the antitumor efficacy of chimpanzee adenovirus vector HPV therapeutic vaccine in mice; A. Flow chart of antitumor research, C57BL/6 mice were subcutaneously inoculated with 1×10 ⁵ TC Four days after -1 cells, a single intramuscular immunization with recombinant adenovirus HPV vaccine (8 × 10 ¹⁰ vps), the same dose of ChAd63-EGFP was used as a negative control; the tumor volume of mice was continuously measured until 39 days after immunization, B. Mouse tumor growth The mean volume change curve of ; the error bars show the mean and standard deviation, C. Survival curves of mice in each group, when the tumor volume of mice was greater than 1500 mm, the mice ^were euthanized, D. The tumor volume changes of a single mouse Curve; partial response was defined as the tumor volume was significantly smaller than that of the negative control group; complete response was defined as the complete disappearance of the tumor in mice by the end of the monitoring period.

Detailed ways

The present invention will be further described in detail below with reference to the embodiments, so that those skilled in the art can implement according to the description.

It should be understood that terms such as "having", "comprising" and "including" as used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

The present invention is the first to construct a novel HPV therapeutic vaccine based on a replication-defective chimpanzee adenovirus vector after a series of in-depth studies. The vaccine can induce a high level of antigen-specific T cell immune response in mice, and the vaccine can not only significantly enhance the HPV antigen-specific T cell response by integrating cytokines GM-CSF or IL-12, but also It greatly enhanced the antitumor efficacy of the vaccine in the TC-1 mouse cervical cancer model, and laid the foundation for the successful development of the HPV vaccine.

In a preferred embodiment, the replication-deficient chimpanzee adenovirus vector comprises a plurality of recombinant ChAd63 and ChAdv3 sequences constructed in the previous stage, wherein the insertion between MluI and EcoRI at ΔE1 site contains HPV16/18-E6/E7 the open reading frame sequence. In a further preferred embodiment, an open reading frame sequence containing the murine GM-CSF or IL-12 gene is inserted between the ΔE3 sites HpaI and Pad. Taking ChAd63 as an example, after constructing the complete sequence in sequence analysis software, entrust a professional gene synthesis company to synthesize the whole genome sequence, and finally obtain a transfection-grade expressible exogenous source covering accurate sequence information and sufficient purification. Three recombinant adenoviral vector plasmids for genes pChAd63-HPV, pChAd63-HPV-mu-GMCSF and pChAd63-HPV-mu-IL12.

The present invention also provides a method for preparing an HPV vaccine, the method comprising: packaging an HPV recombinant adenovirus vector plasmid, and processing to obtain an immunogenic HPV recombinant adenovirus vaccine. Specifically, it includes the following steps:

1) Select chimpanzee adenovirus replication-deficient type 63 or type 3 adenovirus as model virus vectors, and select E6 and E7 of HPV 16 and HPV 18 as model antigens;

2) Insert the nucleotide sequences encoding the E6 and E7 antigen proteins of HPV 16 and HPV 18 alone or together with the nucleotide sequence of the murine cytokine IL-12/GM-CSF into the model virus vector plasmid to construct a recombinant plasmid;

3) After the recombinant plasmid was digested and linearized, it was transfected into adenovirus packaging cells, and the cells cultured to about 80% showed obvious cytopathic changes;

4) Collect the cells, break the cells by repeated freezing and thawing, and collect the supernatant by centrifugation;

5) Infect adenovirus packaging cells with the supernatant, and culture until most cells change from adherence to suspension;

6) Repeatedly expand the culture to a certain volume according to steps 3) and 4), collect the cells, centrifuge after crushing, and take the supernatant;

7) Purify the recombinant adenovirus by taking the supernatant to obtain a virus solution, which is the therapeutic HPV vaccine stock solution. Determination of viral titers is performed according to routine methods in the art.

The present invention also provides a method for evaluating the immunogenicity and antitumor efficacy of the chimpanzee adenovirus vector HPV vaccine in mice, the method comprising: immunizing the purified virus with BALB/c and C57BL/ 6 mice, spleen lymphocytes were isolated two weeks after immunization, and antigen-specific T cell responses were detected by FluroSpot. In addition, the C57BL/6 mouse TC-1 cervical cancer tumor model was constructed, and the mice were immunized with purified HPV recombinant adenovirus according to a certain dose. After immunization, the tumor volume of the mice was continuously measured for about 40 days to evaluate HPV treatment. Antitumor efficacy of sexual vaccines.

The present invention is further described below in conjunction with specific implementation cases. However, it should be understood that the embodiments of the present invention are only used to illustrate the present invention and not to limit the scope of the present invention. The experimental methods without conditions in the following examples are usually carried out in accordance with the conventional experimental conditions or the conditions suggested by the manufacturer of the relevant reagents (kits).

Example 1

1. Experimental materials

1.1. Cells

HEK293 cell line was purchased from the ATCC cell bank in the United States (Cat. No.: CRL-1573) in DMEM (GIBCO, #11995-040) containing 10% fetal bovine serum (GIBCO, #10091-148).

The TC-1 cell line was purchased from the US ATCC Cell Bank (Cat. No.: CRL_2785) in RPMI 1640 (GIBCO, #72400-047) containing 10% fetal bovine serum (GIBCO, #10091-148). 1.2. BALB/c mice and C57BL/6 mice.

The mice involved in this experiment were purchased from Shanghai Xipuer-Bikai Laboratory Animal Co., Ltd., and all animal experiments were carried out in the SPF barrier of Shanghai Laboratory Animal Research Center.

2. Experimental method

2.1. Packaging of recombinant chimpanzee adenovirus (taking ChAd63-HPV-mu-GMCSF recombinant adenovirus as an example)

The plasmid pChAd63-HPV-mu-GMCSF was synthesized by Suzhou Jinweizhi Biotechnology Co., Ltd., and the replication-deficient vector plasmid pChAd63 required for the synthesis was provided by our company. Plasmid pChAd63-HPV-mu-GMCSF was linearized with the restriction enzyme SwaI. Plate a 24-well plate with HEK293 cells, and when the cell density reaches 80%–90%, the linearized pChAd63-HPV-mu-GMCSF digestion product is transfected according to the instructions of the transfection kit TransIT-X2 (Mirus, #MIR6004) 50 μl of transfection mixture was prepared and added, and cytopathic changes were observed every day. The negative control was uninfected cells. About 6 days later, if obvious cytopathic changes were observed, the transfected cell product was collected, and the supernatant was collected by centrifugation after repeated freezing and thawing three times. The infection was expanded to a 12-well plate, and if there were obvious cytopathic changes, the virus packaging was successful. The infection was then expanded to a 6-well plate, and the infected cell product was harvested. After repeated freezing and thawing three times, the supernatant was collected by centrifugation, which could be regarded as the initial virus stock solution.

2.2. Amplification of recombinant chimpanzee adenovirus

When HEK293 cells were cultured in DMEM medium containing 10% fetal bovine serum until the cell density was close to 100%, the initial virus stock solution was added to the cell culture medium, and the cells were continued to be cultured. When the cells become cytopathic and almost all cells change from adherent to floating state, the infected cells can be collected by centrifugation. Resuspend the cells with an appropriate amount of DMEM, freeze and thaw three times to lyse the cells, and centrifuge to get the supernatant. The supernatant can be further amplified repeatedly according to the above method, so that the virus stock solution reaches a certain amount.

2.3. Purification and titer determination of recombinant chimpanzee adenovirus

The amplified virus stock solution was prepared according to the literature (Zhou, D., Zhou.X., Bian, A. (2010). An efficient method of directly cloning chimpanzee adenovirus as a vaccine vector. Nature protocols. 5(11), 1775-1785 .) The described cesium chloride density gradient centrifugation method is used for purification and titer determination, and then glycerol is added and placed in a -80°C refrigerator for long-term storage. The next day, take out 2 μl of the virus to be tested in aliquots from the refrigerator, measure the A ₂₆₀ value of the solution with a NanoPhotometer (IMPLEN, #N60), and calculate the purified virus titer according to the following formula: Titer=A ₂₆₀ ×1.1×10 ¹² vps/ml.

2.4. Western-blot detection of HPV antigen expression

The purified recombinant adenovirus ChAd63-HPV stored at -80°C was used to infect HEK293 cells in a 6-well plate at 10 ¹⁰ vps/well. After overnight incubation, centrifugation was performed at 1,000 rpm for 5 mins, and the supernatant was discarded. Cells were lysed on ice with protein lysis buffer containing protease inhibitors, and the supernatant was collected by centrifugation. An appropriate amount of protein supernatant was mixed with loading buffer, boiled for 10 mins, cooled and then subjected to SDS-PAGE electrophoresis. After electrophoresis, the proteins on the gel were transferred to PVDF membrane. After transfer, the membrane was blocked with 5% nonfat milk for 2h, washed with PBST for 3 times, then added with 1:200 diluted primary antibody (Table 1) and incubated for 1h, then washed with PBST for 3 times and then added with 1:2000 The diluted secondary antibody was incubated for 1 h, and finally the membrane was washed three times with PBST, and then developed with a chemiluminescence kit (Suzhou New Saimei Biotechnology Co., Ltd., #P10100) in the dark. The results showed that HPV proteins could be expressed normally after infected cells (as shown in Figure 3A). Antibody information is: Anti-16-E7: Invitrogen#28-0006; Anti-18-E7: SANTA CRUZ#sc-365035; Anti-16/18-E6: SANTA CRUZ#sc-460; β-Actin: Cell Signalling #3700S; Goatanti-M IgG1-HRP: Invitrogen #PA1-74421; Goat anti-MIgG2a-HRP: Invitrogen #M32207.

2.5. Cytokine expression detected by ELISA

The purified recombinant adenovirus stored at -80°C was used to infect HEK293 cells in a 6-well plate at 1.5×10 ⁸ vps/well. After culturing for 72 hrs, centrifuge at 1,000 rpm for 5 mins at room temperature, collect the culture supernatant, and detect cytokines in the supernatant according to the instructions of Mouse GM-CSF Quantikine ELISA Kit (R&D, #MGM00) and Mouse IL-12p70 Quantikine ELISA Kit (R&D, #M1270). Concentrations of GM-CSF and IL-12. The results showed that the target genes GM-CSF and IL-12 could be correctly expressed and secreted into the extracellular supernatant after the recombinant adenovirus infected cells (Fig. 3B-C).

2.6. Mouse immunity and TC-1 tumor model construction

Intramuscular immunization: Take the purified recombinant adenovirus stored at -80°C, dilute it with PBS, and inject 50 μl each into the left and right hind legs of C57BL/6 mice or BALB/c mice intramuscularly.

Model construction: TC-1 cells were recovered and cultured to passages 8–10, and the cells were collected and resuspended in PBS. Female C57BL/6 mice were depilated 1 day in advance with depilatory cream (Nair) combined with a hair trimmer to depilate the right back and abdomen, and on the 2nd day, 1×10 ⁵ TC-1 cells were subcutaneously inoculated at the depilation area with an injection needle in a total of 50 μl. Tumor growth was continuously monitored after inoculation, and the tumor model was successfully constructed when the tumor was clearly visible on day 4. Then a certain number of mice with relatively uniform tumor size were selected for random group treatment. The long diameter (a) and short diameter (b) of each mouse's tumor were measured and recorded at least twice a week using a vernier caliper, and calculated using the formula, tumor volume = 1/2*a*b*b (mm ³ ).

2.7. T cell response level detected by mouse IFN-γ/IL-5FluoroSpot

Mouse lymphocyte isolation: dissect the spleen, grind it in a 6-well plate pre-added with 2ml RPMI 1640 and copper mesh, filter the cell suspension with copper mesh into a 15ml centrifuge tube, add 3ml RPMI 1640 solution, 250g, 6min , centrifuge at 4°C, discard the supernatant; add 3ml red blood cell lysate (Solarbio, Cat#R1010) to each tube, centrifuge directly at 250g, 6min, 4°C, discard the supernatant; add 5ml RPMI 1640 to each tube to resuspend, 250g, 5min , centrifuge at 4°C, discard the supernatant; add 1 ml of RPMI1640-10% FBS-1% P/S (complete medium) to resuspend, dilute at 40×, and count the cells before use.

Polypeptide synthesis: According to the design of the HPV16/18-E6/E7 amino acid sequence contained in the vaccine, according to the principle of 18 amino acids for each polypeptide and 10 amino acid residues for adjacent polypeptides, a total of 60 polypeptides were synthesized (Table 1). After the polypeptide is synthesized, dissolve it according to the instructions. The concentration of each polypeptide after dissolution is 10 mg/ml, and the final concentration is 5 μg/ml when used.

Table 1. Detected peptides for HPV16/18-E6/E7 antigens

According to the instructions of the kit (MabTech, #FS-4143-2), pre-wet the 96-well PVDF plate with 15 μl of 35% ethanol solution for no more than 1 min, then wash 5 times with 200 μl/well of PBS; dilute the coated antibody (anti- IFN-γmAb & anti-IL-5mAb) to 15 μg/ml, 100 μl/well was added, and coated overnight at 4°C; after 5 washes with 200 μl/well of PBS, 200 μl/well of complete medium was added, and the cells were blocked at room temperature for at least 30 mins. Discard the blocking solution, add 190 μl of cell suspension (3×10 ⁵ cells/well) and 10 μl of polypeptide solution, avoid shaking; the negative control well is 10 μl of peptide dilution, and the positive control well is 5 μg/ml Con A; then add 1: 1000 diluted anti-CD28 antibody solution was co-stimulated; after two days of incubation at 37°C and 5% CO ₂ , secondary antibody incubation, color development and plate reading were performed according to the kit instructions. The results showed that recombinant adenovirus ChAd63-HPV could induce strong HPV antigen-specific T cell immune responses that secreted IFN-γ and IL-2 in C57BL/6 and BALB/c mice (Figure 4). Recombinant adenovirus ChAd63-HPV-mu-GMCSF carrying GM-CSF cytokines can significantly enhance HPV antigen-specific T cell immune responses (Figure 5). Among them, in Figs. 4 and 5, auxiliary markings are also carried out by reference numerals 1-4 directly above the bar graph.

2.8. Evaluation of antitumor efficacy

After the TC-1 model mice with obvious tumors were randomly divided into four groups, the purified recombinant adenovirus was injected into the hind leg muscle by a single injection, and the change trend of the tumor volume of each mouse was continuously observed. The results showed that, compared with the negative control ChAd63-EGFP, the three recombinant adenovirus vector HPV therapeutic vaccines could inhibit the growth of TC-1 tumor; The mu-GMCSF recombinant adenovirus vaccine showed better tumor suppressive effect and higher survival rate, and 60% of the mice showed durable tumor-free growth (Fig. 6). Among them, in FIG. 6, the four recombinant adenovirus vaccines are also marked by the numbers 1-4.

3. Conclusion

In this example, a HPV therapeutic vaccine was successfully constructed by using a chimpanzee adenovirus vector; a single immunization strategy was used to immunize mice, and the immunogenicity of the vaccine in mice and its effect in the TC-1 mouse model were detected 2 weeks after immunization. Anti-tumor efficacy, the results show that a single immunization of recombinant adenovirus HPV therapeutic vaccine can induce strong HPV antigen-specific T cell responses and anti-tumor efficacy in mice.

Although the embodiment of the present invention has been disclosed as above, it is not limited to the application listed in the description and the embodiment, and it can be applied to various fields suitable for the present invention. For those skilled in the art, it can be easily Therefore, the invention is not limited to the specific details without departing from the general concept defined by the appended claims and the scope of equivalents.

sequence listing

<110> Yidao Biotechnology (Suzhou) Co., Ltd.

<120> Therapeutic HPV vaccine based on chimpanzee adenovirus vector, its preparation method and application

<160> 20

<170> SIPOSequenceListing 1.0

<210> 1

<211> 151

<212> PRT

<213> Artificial Sequence

<400> 1

Met Phe Gln Asp Pro Gln Glu Arg Gly Arg Lys Leu Pro Gln Leu Cys

1 5 10 15

Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr

20 25 30

Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Arg Arg

35 40 45

Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Gly Asp

50 55 60

Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys

65 70 75 80

Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu

85 90 95

Cys Asp Leu Leu Ile Arg Cys Ile Asn Gly Gln Lys Pro Leu Cys Pro

100 105 110

Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Thr

115 120 125

Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg

130 135 140

Thr Arg Arg Glu Thr Gln Leu

145 150

<210> 2

<211> 98

<212> PRT

<213> Artificial Sequence

<400> 2

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln

1 5 10 15

Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser

20 25 30

Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp

35 40 45

Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Gly Asp Ser Thr

50 55 60

Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu

65 70 75 80

Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln

85 90 95

Lys Pro

<210> 3

<211> 158

<212> PRT

<213> Artificial Sequence

<400> 3

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Gly Tyr Lys Leu Pro Asp

1 5 10 15

Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys

20 25 30

Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala

35 40 45

Arg Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala

50 55 60

Gly His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His

65 70 75 80

Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr

85 90 95

Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Gly Gln Lys Pro Leu

100 105 110

Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His

115 120 125

Asn Thr Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg

130 135 140

Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val

145 150 155

<210> 4

<211> 105

<212> PRT

<213> Artificial Sequence

<400> 4

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu

1 5 10 15

Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Gly His Gly Gln Leu Ser

20 25 30

Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His

35 40 45

Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met

50 55 60

Cys Cys Lys Gly Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala

65 70 75 80

Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe

85 90 95

Val Cys Pro Trp Cys Ala Ser Gln Gln

100 105

<210> 5

<211> 26

<212> PRT

<213> Artificial Sequence

<400> 5

Arg Lys Arg Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln

1 5 10 15

Ala Gly Asp Val Glu Glu Asn Pro Gly Pro

20 25

<210> 6

<211> 31

<212> PRT

<213> Artificial Sequence

<400> 6

Arg Lys Arg Arg Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe

1 5 10 15

Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro

20 25 30

<210> 7

<211> 597

<212> PRT

<213> Artificial Sequence

<400> 7

Met Phe Gln Asp Pro Gln Glu Arg Gly Arg Lys Leu Pro Gln Leu Cys

1 5 10 15

Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr

20 25 30

Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Arg Arg

35 40 45

Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Gly Asp

50 55 60

Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys

65 70 75 80

Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu

85 90 95

Cys Asp Leu Leu Ile Arg Cys Ile Asn Gly Gln Lys Pro Leu Cys Pro

100 105 110

Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Thr

115 120 125

Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg

130 135 140

Thr Arg Arg Glu Thr Gln Leu Arg Lys Arg Arg Gly Ser Gly Ala Pro

145 150 155 160

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val

165 170 175

Glu Ser Asn Pro Gly Pro His Gly Asp Thr Pro Thr Leu His Glu Tyr

180 185 190

Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln

195 200 205

Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly

210 215 220

Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys

225 230 235 240

Lys Gly Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp

245 250 255

Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys

260 265 270

Pro Ile Cys Ser Gln Lys Pro Arg Lys Arg Arg Gly Ser Gly Ala Thr

275 280 285

Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly

290 295 300

Pro Ala Arg Phe Glu Asp Pro Thr Arg Arg Gly Tyr Lys Leu Pro Asp

305 310 315 320

Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys

325 330 335

Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala

340 345 350

Arg Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala

355 360 365

Gly His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His

370 375 380

Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr

385 390 395 400

Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Gly Gln Lys Pro Leu

405 410 415

Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His

420 425 430

Asn Thr Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg

435 440 445

Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val Arg Lys

450 455 460

Arg Arg Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu

465 470 475 480

Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro His Gly Pro

485 490 495

Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu

500 505 510

Ile Pro Val Asp Leu Leu Gly His Gly Gln Leu Ser Asp Ser Glu Glu

515 520 525

Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu Pro Ala Arg

530 535 540

Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Gly

545 550 555 560

Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg

565 570 575

Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp

580 585 590

Cys Ala Ser Gln Gln

595

<210> 8

<211> 1794

<212> DNA

<213> Artificial Sequence

<400> 8

atgtttcagg atccccagga gcggggccgc aagctgccac agctgtgcac agagctccag 60

acaaccattc acgatattat tctcgagtgc gtctactgta agcagcagct cctgcgccgg 120

gaggtctacg acttcgctag acgcgacctg tgtatcgtct accgcgatgg aaatccatac 180

gccgtcggcg ataagtgcct caagttttac tctaagattt ctgagtaccg gcactactgt 240

tactcactgt acggaaccac cctcgagcag cagtacaata agcctctgtg tgatctgctc 300

attagatgca ttaatggcca gaagcctctc tgtccagagg agaagcagcg gcacctcgat 360

aagaagcagc ggtttcacaa tactagggga aggtggaccg gaaggtgtat gtcatgttgt 420

cggtcatcaa gaactagacg cgagacacag ctcagaaaga ggcgcgggtc aggcgcacca 480

gtcaagcaga ctctgaactt tgatctcctc aagctcgctg gcgacgtcga gtctaatcct 540

ggcccccacg gcgacacccc aaccctccac gagtacatgc tggatctcca gcccgagaca 600

accgacctct acgggtacgg gcagctcaat gattcatcag aggaggagga tgagattgat 660

ggccccgccg gacaggctga gcccgatagg gcccactaca atatcgtgac attttgttgc 720

aagggcgatt caacactccg cctgtgcgtg cagtcaaccc acgtggatat tcggactctc 780

gaggatctgc tcatgggaac actgggaatt gtgtgcccta tttgttccca gaagcctaga 840

aagaggcgcg ggtccggcgc aacaaatttt agcctgctca agcaggctgg cgacgtcgag 900

gagaatcctg ggcccgctag gtttgaggat ccaactagac gcgggtacaa gctccccgat 960

ctgtgtacag agctgaatac atcactccag gatattgaga ttacttgcgt gtactgtaag 1020

accgtcctcg agctgactga ggtctttgag ttcgctagaa aggatctctt cgtggtctac 1080

cgggattcta tcccacacgc cgccggacac aagtgcattg acttttactc tcgcattagg 1140

gagctcaggc actactccga tagcgtctac ggggatacac tggagaagct gactaatact 1200

ggactgtaca atctgctcat tagatgcctg cgcggacaga agcctctcaa tcccgctgag 1260

aagctgcggc acctgaatga gaagagacgg tttcacaata ccgccggaca ctaccggggc 1320

cagtgtcact cttgttgtaa tagggctagg caggagcggc tccagagacg ccgcgagact 1380

caggtccgca agaggcgcgg gtccggcgca cccgtgaagc agaccctgaa ctttgatctc 1440

ctgaagctcg ctggggacgt ggagtctaac cctgggccac acggaccaaa ggctaccctc 1500

caggatatcg tcctgcacct cgagccacag aatgagattc ccgtcgacct gctcggccac 1560

ggacagctgt ccgatagcga ggaggagaac gatgagattg atggggtgaa tcaccagcac 1620

ctgcccgcta gacgcgccga gccacagcgg cacaccatgc tgtgtatgtg ttgcaagggg 1680

gaggcacgca tcgagctggt ggtggagtct tccgccgatg acctcagggc ttttcagcag 1740

ctctttctga ataccctgtc cttcgtgtgc ccttggtgcg cttcccagca gtga 1794

<210> 9

<211> 141

<212> PRT

<213> Artificial Sequence

<400> 9

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu

1 5 10 15

Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His

20 25 30

Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val

35 40 45

Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys

50 55 60

Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu

65 70 75 80

Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser

85 90 95

Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr

100 105 110

Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu

115 120 125

Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys

130 135 140

<210> 10

<211> 426

<212> DNA

<213> Artificial Sequence

<400> 10

atgtggctgc agaatttact gtttttaggc atcgtggtgt actctttaag cgcccccact 60

cgttccccta tcacagtgac tcgtccttgg aagcacgtgg aggccatcaa ggaagcttta 120

aatttactgg acgacatgcc cgtgacttta aatgaggagg tcgaggtggt gagcaacgag 180

ttcagcttca agaagctgac ttgtgtgcag actcgtctga agatcttcga gcaaggtctg 240

aggggcaact tcaccaagct gaagggcgct ttaaacatga ccgccagcta ctaccagacc 300

tactgccccc ccacccccga gacagattgc gagacccaag ttaccaccta cgccgacttc 360

atcgactctt taaagacctt tttaaccgac atccccttcg agtgcaaaaa gcccggtcag 420

aagtaa 426

<210> 11

<211> 572

<212> PRT

<213> Artificial Sequence

<400> 11

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu

1 5 10 15

Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val

20 25 30

Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu

35 40 45

Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln

50 55 60

Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys

65 70 75 80

Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr

85 90 95

Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp

100 105 110

Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys

115 120 125

Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln

130 135 140

Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro

145 150 155 160

Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys

165 170 175

Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln

180 185 190

Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu

195 200 205

Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser

210 215 220

Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln

225 230 235 240

Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro

245 250 255

Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val

260 265 270

Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys

275 280 285

Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln

290 295 300

Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn

305 310 315 320

Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Val

325 330 335

Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu

340 345 350

Ser Asn Pro Gly Pro Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala

355 360 365

Thr Leu Ala Leu Leu Asn His Leu Ser Leu Ala Arg Val Ile Pro Val

370 375 380

Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr

385 390 395 400

Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser

405 410 415

Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr

420 425 430

Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser

435 440 445

Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu

450 455 460

Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile

465 470 475 480

Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala

485 490 495

Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met

500 505 510

Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu

515 520 525

Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val

530 535 540

Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val

545 550 555 560

Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala

565 570

<210> 12

<211> 1719

<212> DNA

<213> Artificial Sequence

<400> 12

atgtgccccc agaagctgac catcagctgg tttgccatcg tgctgctggt ctccccttta 60

atggccatgt gggagctgga gaaggatgtg tacgtcgtgg aggtggactg gacacccgat 120

gccccccggcg aaaccgtgaa tttaacttgt gacacccccg aagaggacga catcacttgg 180

accagcgatc agagacacgg cgtgatcggc tccggcaaga ctttaaccat caccgtgaag 240

gagttcctcg atgccggcca gtatacttgt cacaaaggcg gcgagacact cagccactcc 300

catttactgc tgcacaagaa ggagaacggc atctggagca cagagatcct caagaatttc 360

aagaacaaga ccttttttaaa gtgcgaggcc cccaactact ccggtcgttt tacttgttct 420

tggctggtcc agaggaatat ggatttaaag ttcaatatca agagctccag cagcagcccc 480

gactctcgtg ccgtgacatg tggcatggcc tctttatccg ccgagaaggt gaccctcgac 540

cagagggact acgagaagta cagcgtgagc tgccaagaag acgtcacttg tcctaccgct 600

gaggagactt tacccatcga actggcttta gaggctcgtc agcagaacaa gtacgagaat 660

tactccacaa gcttctttat cagagacatt atcaagcccg atccccccaa gaatctgcag 720

atgaagcccc tcaagaactc ccaagttgag gtgagctggg agtaccccga tagctggtcc 780

accccccact cctacttctc tttaaagttt ttcgtgagga tccagaggaa gaaggagaag 840

atgaaggaga ccgaggaagg ctgcaaccag aagggcgcct ttctggtgga gaagaccagc 900

accgaggtgc agtgtaaggg cggcaatgtg tgcgtgcaag ctcaagatcg ttactacaac 960

agcagctgca gcaagtgggc ttgtgtgcct tgtagggtga ggtccgtcaa gcagactctg 1020

aactttgatc tcctcaagct cgctggcgac gtcgagtcta atcctggccc catgtgccag 1080

agcagatatt tactgttttt agccacttta gctttactga accatttatc tttagccaga 1140

gtgatccccg ttagcggccc cgctaggtgt ttaagccagt ctcgtaatct gctgaagacc 1200

accgacgaca tggtgaagac cgctcgtgag aagctcaagc actacagctg caccgccgag 1260

gatatcgacc acgaggacat cactcgtgac cagaccagca cactgaagac ttgtttacct 1320

ctggagctgc acaagaacga gagctgttta gccactcgtg agaccagctc caccacaaga 1380

ggctcttgtt taccccccca gaagacctct ttaatgatga ctttatgtct gggcagcatc 1440

tacgaagatt taaagatgta ccagaccgag ttccaagcta tcaatgccgc tttacagaac 1500

cacaaccacc agcagatcat tttagacaag ggcatgctgg tggccatcga cgaactgatg 1560

cagtccctca accacaacgg cgagacttta agacagaagc cccccgtggg agaggctgac 1620

ccttatcgtg tcaagatgaa gctgtgcatt ttactgcacg ccttcagcac tcgtgtggtg 1680

accatcaatc gtgtgatggg ctatttaagc tccgcctaa 1719

<210> 13

<211> 31593

<212> DNA

<213> Artificial Sequence

<400> 13

atttaaatgg cgcgccgggc ccgggccgca tagttaagcc agccccgaca cccgccaaca 60

cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg 120

accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga 180

cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct 240

tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc 300

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa 360

tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt 420

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct 480

gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc 540

cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta 600

tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac 660

tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc 720

atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac 780

ttacttctga caacgatcgg aggaccgaag gagctaaccg ctttttttgca caacatgggg 840

gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac 900

gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc 960

gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt 1020

gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga 1080

gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc 1140

cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag 1200

atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca 1260

tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc 1320

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca 1380

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc 1440

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta 1500

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt 1560

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc 1620

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg 1680

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg 1740

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag 1800

ctttgagata gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc 1860

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat 1920

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg 1980

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc 2040

tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt 2100

accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca 2160

gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg 2220

attcattaat gcagctggca cgacaggttt cccgactgga tttaaatcat catcaataat 2280

atacctcaaa cttttggtgc gcgttaatat gcaaatgagg tgtttgaatt tggggatgcg 2340

gggcgctgat tggctgagag acgggcgacc gttaggggcg gggcgggtga cgttttgatg 2400

acgtggccgt gaggcggagc cggtttgcaa gttctcgtgg gaaaagtgac gtcaaacgag 2460

gtgtggtttg aacacggaaa tactcaattt tcccgcgctc tctgacagga aatgaggtgt 2520

ttctgggcgg atgcaagtga aaacgggcca ttttcgcgcg aaaactgaat gaggaagtga 2580

aaatctgagt aattccgcgt ttatggcagg gaggagtatt tgccgagggc cgagtagact 2640

ttgaccgatt acgtgggggt ttcgattacc gtatttttca cctaaatttc cgcgtacggt 2700

gtcaaagtcc ggtgttttta cgtaggcgtc agctgatcgc cagggtattt aaacctgcgc 2760

tctctagtca agaggccact cttgagtgcc agcgagtaga gttttctcct ccgcgccgcg 2820

agtcagatct acactttgaa aggcgatcgc cgatatcatt tccccgaaaa gtgccacctg 2880

accgtaacta taacggtcct aaggtagcga aagctcagat ctcccgatcc cctatggtgc 2940

actctcagta caatctgctc tgatgccgca tagttaagcc agtatctgct ccctgcttgt 3000

gtgttggagg tcgctgagta gtgcgcgagc aaaatttaag ctacaacaag gcaaggcttg 3060

accgacaatt gcatgaagaa tctgcttagg gttaggcgtt ttgcgctgct tcgcgatgta 3120

cgggccagat atacgcgttg aattcatcta tgtcgggtgc ggagaaagag gtaatgaaat 3180

ggcattatgg gtattatggg tctgcattaa tgaatcggcc agatatcgac atatgctggc 3240

caccgtacat gtggcttccc atgctcgcaa gccctggccc gagttcgagc acaatgtcat 3300

gaccaggtgc aatatgcatc tggggtcccg gcgatcgccc gaggcatgtt catgccctac 3360

cagtgcaaca tgcaatttgt gaaggtgctg ctggagcccg atgccatgtc cagagtgagc 3420

ctgacgggggg tgtttgacat gaatgtggag ctgtggaaaa ttctgagata tgatgaatcc 3480

aagaccaggt gccgggcctg cgaatgcgga ggcaagcacg ccaggcttca gcccgtgtgt 3540

gtggaggtga cggaggacct gcgacccgat catttggtgt tgtcctgcaa cgggacggag 3600

ttcggctcca gcggggaaga atctgactag agtgagtagt gtttgggggt gggtgggagc 3660

ctgcatgatg ggcagaatga ctaaaatctg tgtttttctg tgtgttgcag cagcatgagc 3720

ggaagcgcct cctttgaggg aggggtattc agcccttatc tgacggggcg tctcccctcc 3780

tgggcgggag tgcgtcagaa tgtgatggga tccacggtgg acggccggcc cgtgcagccc 3840

gcgaactctt caaccctgac ctacgcgacc ctgagctcct cgtccgtgga cgcagctgcc 3900

gccgcagctg ctgcttccgc cgccagcgcc gtgcgcggaa tggccctggg cgccggctac 3960

tacagctctc tggtggccaa ctcgagttcc accaataatc ccgccagcct gaacgaggag 4020

aagctgttgc tgctgatggc ccagctcgag gccctgaccc agcgcctggg cgagctgacc 4080

cagcaggtgg ctcagctgca ggcggagacg cgggccgcgg ttgccacggt gaaaaccaaa 4140

taaaaaatga atcaataaat aaacggagac ggttgttgat tttaacacag agtcttgaat 4200

ctttatttga tttttcgcgc gcggtaggcc ctggaccacc ggtctcgatc attgagcacc 4260

cggtggatct tttccaggac ccggtagagg tgggcttgga tgttgaggta catgggcatg 4320

agcccgtccc gggggtggag gtagctccat tgcagggcct cgtgctcggg ggtggtgttg 4380

taaatcaccc agtcatagca ggggcgcagg gcgtggtgct gcacgatgtc tttgaggagg 4440

agactgatgg ccacgggcag ccccttggtg taggtgttga cgaacctatt gagctgggag 4500

ggatgcatgc ggggggagat gagatgcatc ttggcctgga tcttgagatt ggcgatgttc 4560

ccgccgat cccgccgggg gttcatgttg tgcaggacca ccagcacggt gtatccggtg 4620

cacttgggga atttgtcatg caacttggaa gggaaggcgt gaaagaattt ggagacgccc 4680

ttgtgaccgc ccaggttttc catgcactca tccatgatga tggcgatggg cccgtgggcg 4740

gcggcctggg caaagacgtt tcgggggtcg gacacatcgt agttgtggtc ctgggtgagc 4800

tcgtcatagg ccattttaat gaatttgggg cggagggtac ccgactgggg gacaaaggtg 4860

ccctcgatcc cgggggcgta gttcccctcg cagatctgca tctcccaggc cttgagctcg 4920

gaggggggga tcatgtccac ctgcggggcg atgaaaaaaa cggtttccgg ggcgggggag 4980

atgagctgcg ccgaaagcag gttccggagc agctgggact tgccgcagcc ggtggggccg 5040

tagatgaccc cgatgaccgg ctgcaggtgg tagttgaggg agagacagct gccgtcctcg 5100

cggaggaggg gggccacctc gttcatcatc tcgcgcacat gcatgttctc gcgcacgagt 5160

tccgccagga ggcgctcgcc ccccagcgag aggagctctt gcagcgaggc gaagtttttc 5220

agcggcttga gcccgtcggc catgggcatt ttggagaggg tctgttgcaa gagttccaga 5280

cggtcccaga gctcggtgat gtgctctagg gcatctcgat ccagcagacc tcctcgtttc 5340

gcgggttggg gcgactgcgg gagtagggca ccaggcgatg ggcgtccagc gaggccaggg 5400

tccggtcctt ccagggtcgc agggtccgcg tcagcgtggt ctccgtcacg gtgaaggggt 5460

gcgcgccggg ctgggcgctt gcgagggtgc gcttcaggct catccggctg gtcgagaacc 5520

gctcccggtc ggcgccctgc gcgtcggcca ggtagcaatt gagcatgagt tcgtagttga 5580

gcgcctcggc cgcgtggccc ttggcgcgga gcttaccttt ggaagtgtgt ccgcagacgg 5640

gacagaggag ggacttgagg gcgtagagct tgggggcgag gaagacggac tcgggggcgt 5700

aggcgtccgc gccgcagctg gcgcagacgg tctcgcactc cacgagccag gtgaggtcgg 5760

ggcggtcggg gtcaaaaacg aggtttcctc cgtgcttttt gatgcgtttc ttacctctgg 5820

tctccatgag ctcgtgtccc cgctgggtga caaagaggct gtccgtgtcc ccgtagaccg 5880

actttatggg ccggtcctcg agcggggtgc cgcggtcctc gtcgtagagg aaccccgccc 5940

actccgagac gaaggcccgg gtccaggcca gcacgaagga ggccacgtgg gaggggtagc 6000

ggtcgttgtc caccagcggg tccaccttct ccagggtatg caagcacatg tccccctcgt 6060

ccacatccag gaaggtgatt ggcttgtaag tgtaggccac gtgaccgggg gtcccggccg 6120

ggggggtata aaagggggcg ggcccctgct cgtcctcact gtcttccgga tcgctgtcca 6180

ggagcgccag ctgttggggt aggtattccc tctcgaaggc gggcatgacc tcggcactca 6240

ggttgtcagt ttctagaaac gaggaggatt tgatattgac ggtgccgttg gagacgcctt 6300

tcatgagccc ctcgtccatc tggtcagaaa agacgatctt tttgttgtcg agcttggtgg 6360

cgaaggagcc gtagagggcg ttggagagca gcttggcgat ggagcgcatg gtctggttct 6420

tttccttgtc ggcgcgctcc ttggcggcga tgttgagctg cacgtactcg cgcgccacgc 6480

acttccattc ggggaagacg gtggtgagct cgtcgggcac gattctgacc cgccagccgc 6540

ggttgtgcag ggtgatgagg tccacgctgg tggccacctc gccgcgcagg ggctcgttgg 6600

tccagcagag gcgcccgccc ttgcgcgagc agaagggggg cagcgggtcc agcatgagct 6660

cgtcgggggg gtcggcgtcc acggtgaaga tgccgggcag gagctcgggg tcgaagtagc 6720

tgatgcaggt gcccagatcg tccagacttg cttgccagtc gcgcacggcc agcgcgcgct 6780

cgtaggggct gaggggcgtg ccccagggca tggggtgcgt gagcgcggag gcgtacatgc 6840

cgcagatgtc gtagacgtag aggggctcct ggaggacgcc gatgtaggtg gggtagcagc 6900

gccccccgcg gatgctggcg cgcacgtagt cgtacagctc gtgcgagggc gcgaggagcc 6960

ccgtgccgag attggagcgc tgcggctttt cggcgcggta gacgatctgg cggaagatgg 7020

cgtgggagtt ggaggagatg gtgggcctct ggaagatgtt gaagtgggca tggggcagtc 7080

cgaccgagtc cctgatgaag tgggcgtagg agtcctgcag cttggcgacg agctcggcgg 7140

tgacgaggac gtccagggcg cagtagtcga gggtctcttg gatgatgtcg tacttgagct 7200

ggcccttctg cttccacagc tcgcggttga gaaggaactc ttcgcggtcc ttccagtact 7260

cttcgagggg gaacccgtcc tgatcggcac ggtaagagcc caccatgtag aactggttga 7320

cggccttgta ggcgcagcag cccttctcca cggggagggc gtaagcttgc gcggccttgc 7380

gcagggaggt gtgggtgagg gcgaaggtgt cgcgcaccat gactttgagg aactggtgct 7440

tgaagtcgag gtcgtcgcag ccgccctgct cccagagctg gaagtccgtg cgcttcttgt 7500

aggcggggtt gggcaaagcg aaagtaacat cgttgaagag gatcttgccc gcgcggggca 7560

tgaagttgcg agtgatgcgg aaaggctggg gcacctcggc ccggttgttg atgacctggg 7620

cggcgaggac gatctcgtcg aagccgttga tgttgtgccc gacgatgtag agttccacga 7680

atcgcgggcg gcccttgacg tggggcagct tcttgagctc gtcgtaggtg agctcggcgg 7740

ggtcgctgag cccgtgctgc tcgagggccc agtcggcgac gtgggggttg gcgctgagga 7800

aggaagtcca gagatccacg gccagggcgg tctgcaagcg gtcccggtac tgacggaact 7860

gctggcccac ggccatttttt tcgggggtga cgcagtagaa ggtgcggggg tcgccgtgcc 7920

agcggtccca cttgagctgg agggcgaggt cgtgggcgag ctcgacgagc ggcgggtccc 7980

cggagagttt catgaccagc atgaagggga cgagctgctt gccgaaggac cccatccagg 8040

tgtaggtttc cacatcgtag gtgaggaaga gcctttcggt gcgaggatgc gagccgatgg 8100

ggaagaactg gatctcctgc caccagttgg aggaatggct gttgatgtga tggaagtaga 8160

aatgccgacg gcgcgccgag cactcgtgct tgtgtttata caagcgtccg cagtgctcgc 8220

aacgctgcac gggatgcacg tgctgcacga gctgtacctg ggttcctttg acgaggaatt 8280

tcagtgggca gtggagcgct ggcggctgca tctggtgctg tactacgtcc tggccatcgg 8340

cgtggccatc gtctgcctcg atggtggtca tgctgacgag cccgcgcggg aggcaggtcc 8400

agacctcggc tcggacgggt cggagagcga ggacgagggc gcgcaggccg gagctgtcca 8460

gggtcctgag acgctgcgga gtcaggtcag tgggcagcgg cggcgcgcgg ttgacttgca 8520

ggagcttttc cagggcgcgc gggaggtcca gatggtactt gatctccacg gcgccgttgg 8580

tggcgacgtc cacggcttgc agggtcccgt gcccctgggg cgccaccacc gtgccccgtt 8640

tcttcttggg cggcggcggc tccatgctta gaagcggcgg cgaggacgcg cgccgggcgg 8700

caggggcggc tcggggcccg gaggcagggg cggcaggggc acgtcggcgc cgcgcgcggg 8760

caggttctgg tactgcgccc ggagaagact ggcgtgagcg acgacgcgac ggttgacgtc 8820

ctggatctga cgcctctggg tgaaggccac gggacccgtg agtttgaacc tgaaagagag 8880

ttcgacagaa tcaatctcgg tatcgttgac ggcggcctgc cgcaggatct cttgcacgtc 8940

gcccgagttg tcctggtagg cgatctcggt catgaactgc tcgatctcct cctcctgaag 9000

gtctccgcgg ccggcgcgct cgacggtggc cgcgaggtcg ttggagatgc ggcccatgag 9060

ctgcgagaag gcgttcatgc cggcctcgtt ccagacgcgg ctgtagacca cggctccgtc 9120

ggggtcgcgc gcgcgcatga ccacctgggc gaggttgagc tcgacgtggc gcgtgaagac 9180

cgcgtagttg cagaggcgct ggtagaggta gttgagcgtg gtggcgatgt gctcggtgac 9240

gaagaagtac atgatccagc ggcggagcgg catctcgctg acgtcgccca gggcttccaa 9300

gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9360

gacggtcaac tcctcctcca gaagacggat gagctcggcg atggtggcgc gcacctcgcg 9420

ctcgaaggcc ccggggggct cctcttccat ttcctcctct tcctcctcca ctaacatctc 9480

ttctacttcc tcctcaggag gcggcggcgg gggaggggcc ctgcgtcgcc ggcggcgcac 9540

gggcagacgg tcgatgaagc gctcgatggt ctccccgcgc cggcgacgca tggtctcggt 9600

gacggcgcgc ccgtcctcgc ggggccgcag cgtgaagacg ccgccgcgca tctccaggtg 9660

gccgccgggg gggtctccgt tgggcaggga gagggcgctg acgatgcatc ttatcaattg 9720

acccgtaggg actccgcgca aggacctgag cgtctcgaga tccacgggat ccgaaaaccg 9780

ctgaacgaag gcttcgagcc agtcgcagtc gcaaggtagg ctgagcccgg tttcttgttc 9840

ttcgggtatt tggtcgggag gcgggcgggc gatgctgctg gtgatgaagt tgaagtaggc 9900

ggtcctgaga cggcggatgg tggcgaggag caccaggtcc ttgggcccgg cttgctggat 9960

gcgcagacgg tcggccatgc cccaggcgtg gtcctgacac ctggcgaggt ccttgtagta 10020

gtcctgcatg agccgctcca cgggcacctc ctcctcgccc gcgcggccgt gcatgcgcgt 10080

gagcccgaac ccgcgctgcg gctggacgag cgccaggtcg gcgacgacgc gctcggcgag 10140

gatggcctgc tggatctggg tgagggtggt ctggaagtcg tcgaagtcga cgaagcggtg 10200

gtaggctccg gtgttgatgg tgtaggagca gttggccatg acggaccagt tgacggtctg 10260

gtggccgggg cgcacgagct cgtggtactt gaggcgcgag taggcgcgcg tgtcgaagat 10320

gtagtcgttg caggtgcgca cgaggtactg gtatccgacg aggaagtgcg gcggcggctg 10380

gcggtagagc ggccatcgct cggtggcggg ggcgccgggc gcgaggtcct cgagcatgag 10440

gcggtggtag ccgtagatgt acctggacat ccaggtgatg ccggcggcgg tggtggaggc 10500

gcgcgggaac tcgcggacgc ggttccagat gttgcgcagc ggcaggaagt agttcatggt 10560

ggccgcggtc tggcccgtga ggcgcgcgca gtcgtggatg ctctagacat acgggcaaaa 10620

acgaaagcgg tcagcggctc gactccgtgg cctggaggct aagcgaacgg gttgggctgc 10680

gcgtgtaccc cggttcgaat ctcgaatcag gctggagccg cagctaacgt ggtactggca 10740

ctcccgtctc gacccaagcc tgctaacgaa acctccagga tacggaggcg ggtcgttttt 10800

tggccttggt cgctggtcat gaaaaactag taagcgcgga aagcggccgc ccgcgatggc 10860

tcgctgccgt agtctggaga aagaatcgcc agggttgcgt tgcggtgtgc cccggttcga 10920

gcctcagcgc tcggcgccgg ccggattccg cggctaacgt gggcgtggct gccccgtcgt 10980

ttccaagacc ccttagccag ccgacttctc cagttacgga gcgagcccct ctttttttct 11040

tgtgtttttg ccagatgcat cccgtactgc ggcagatgcg cccccaccct ccaccacaac 11100

cgcccctacc gcagcagcag caacagccgg cgcttctgcc cccgccccag cagcagcagc 11160

cagccactac cgcggcggcc gccgtgagcg gagccggcgt tcagtatgac ctggccttgg 11220

aagagggcga ggggctggcg cggctggggg cgtcgtcgcc ggagcggcac ccgcgcgtgc 11280

agatgaaaag ggacgctcgc gaggcctacg tgcccaagca gaacctgttc agagacagga 11340

gcggcgagga gcccgaggag atgcgcgcct cccgcttcca cgcggggcgg gagctgcggc 11400

gcggcctgga ccgaaagcgg gtgctgaggg acgaggattt cgaggcggac gagctgacgg 11460

ggatcagccc cgcgcgcgcg cacgtggccg cggccaacct ggtcacggcg tacgagcaga 11520

ccgtgaagga ggagagcaac ttccaaaaat ccttcaacaa ccacgtgcgc acgctgatcg 11580

cgcgcgagga ggtgaccctg ggcctgatgc acctgtggga cctgctggag gccatcgtgc 11640

agaaccccac gagcaagccg ctgacggcgc agctgtttct ggtggtgcag cacagtcggg 11700

acaacgagac gttcagggag gcgctgctga atatcaccga gcccgagggc cgctggctcc 11760

tggacctggt gaacattctg cagagcatcg tggtgcagga gcgcgggctg ccgctgtccg 11820

agaagctggc ggccatcaac ttctcggtgc tgagcctggg caagtactac gctaggaaga 11880

tctacaagac cccgtacgtg cccatagaca aggaggtgaa gatcgatggg ttttacatgc 11940

gcatgaccct gaaagtgctg accctgagcg acgatctggg ggtgtaccgc aacgacagga 12000

tgcaccgcgc ggtgagcgcc agccgccggc gcgagctgag cgaccaggag ctgatgcaca 12060

gcctgcagcg ggccctgacc ggggccggga ccgaggggga gagctacttt gacatgggcg 12120

cggacctgcg ctggcagccc agccgccggg ccttggaagc tgccggcggc gtgccctacg 12180

tggaggaggt ggacgatgag gaggaggagg gcgagtacct ggaagactga tggcgcgacc 12240

gtatttttgc tagatgcagc aacagccacc gccgccgcct cctgatcccg cgatgcgggc 12300

ggcgctgcag agccagccgt ccggcattaa ctcctcggac gattggaccc aggccatgca 12360

acgcatcatg gcgctgacga cccgcaatcc cgaagccttt agacagcagc ctcaggccaa 12420

ccggctctcg gccatcctgg aggccgtggt gccctcgcgc tcgaacccca cgcacgagaa 12480

ggtgctggcc atcgtgaacg cgctggtgga gaacaaggcc atccgcggcg acgaggccgg 12540

gctggtgtac aacgcgctgc tggagcgcgt ggcccgctac aacagcacca acgtgcagac 12600

gaacctggac cgcatggtga ccgacgtgcg cgaggcggtg tcgcagcgcg agcggttcca 12660

ccgcgagtcg aacctgggct ccatggtggc gctgaacgcc ttcctgagca cgcagcccgc 12720

caacgtgccc cggggccagg aggactacac caacttcatc agcgcgctgc ggctgatggt 12780

ggccgaggtg ccccagagcg aggtgtacca gtcggggccg gactacttct tccagaccag 12840

tcgccagggc ttgcagaccg tgaacctgag ccaggctttc aagaacttgc agggactgtg 12900

gggcgtgcag gccccggtcg gggaccgcgc gacggtgtcg agcctgctga cgccgaactc 12960

gcgcctgctg ctgctgctgg tggcgccctt cacggacagc ggcagcgtga gccgcgactc 13020

gtacctgggc tacctgctta acctgtaccg cgaggccatc gggcaggcgc acgtggacga 13080

gcagacctac caggagatca cccacgtgag ccgcgcgctg ggccaggagg acccgggcaa 13140

cctggaggcc accctgaact tcctgctgac caaccggtcg cagaagatcc cgccccagta 13200

cgcgctgagc accgaggagg agcgcatcct gcgctacgtg cagcagagcg tggggctgtt 13260

cttgatgcag gagggggcca cgcccagcgc cgcgctcgac atgaccgcgc gcaacatgga 13320

gcccagcatg tacgcccgca accgcccgtt catcaataag ctgatggact acttgcatcg 13380

ggcggccgcc atgaactcgg actactttac caacgccatc ttgaacccgc actggctccc 13440

gccgcccggg ttctacacgg gcgagtacga catgcccgac cccaacgacg ggttcctgtg 13500

ggacgacgtg gacagcagcg tgttctcgcc gcggcccacc accaccaccg tgtggaagaa 13560

agagggcggg gaccggcggc cgtcctcggc gctgtccggt cgcgcgggtg ctgccgcggc 13620

ggtgcccgag gctgccagcc ccttcccgag cctgcccttt tcgctgaaca gcgtgcgcag 13680

cagcgagctg ggtcggctga cgcggccgcg cctgctgggc gaggaggagt acctgaacga 13740

ctccttgttg aagcccgagc gcgagaagaa cttccccaat aacgggatag agagcctggt 13800

ggacaagatg agccgctgga agacgtacgc gcacgagcac agggacgagc cccgagctag 13860

cagcgcaggc acccgtagac gccagcggca cgacaggcag cggggactgg tgtgggacga 13920

tgaggattcc gccgacgaca gcagcgtgtt ggacttgggt gggagtggtg gtggtaaccc 13980

gttcgctcac ctgcgccccc gtatcgggcg cctgatgtaa gaatctgaaa aaataaaaga 14040

cggtactcac caaggccatg gcgaccagcg tgcgttcttc tctgttgttt gtagtagtat 14100

gatgaggcgc gtgtacccgg agggtcctcc tccctcgtac gagagcgtga tgcagcaggc 14160

ggtggcggcg gcgatgcagc ccccgctgga ggcgccttac gtgcccccgc ggtacctggc 14220

gcctacggag gggcggaaca gcattcgtta ctcggagctg gcacccttgt acgataccac 14280

ccggttgtac ctggtggaca acaagtcggc ggacatcgcc tcgctgaact accagaacga 14340

ccacagcaac ttcctgacca ccgtggtgca gaacaacgat ttcaccccca cggaggccag 14400

cacccagacc atcaactttg acgagcgctc gcggtggggc ggccagctga aaaccatcat 14460

gcacaccaac atgcccaacg tgaacgagtt catgtacagc aacaagttca aggcgcgggt 14520

gatggtctcg cgcaagaccc ccaacggggt cacggtaggg gatgattatg atggtagtca 14580

ggacgagctg acctacgagt gggtggagtt tgagctgccc gagggcaact tctcggtgac 14640

catgaccatc gatctgatga acaacgccat catcgacaac tacttggcgg tggggcggca 14700

gaacggggtg ctggagagcg acatcggcgt gaagttcgac acgcgcaact tccggctggg 14760

ctgggacccc gtgaccgagc tggtgatgcc gggcgtgtac accaacgagg ccttccaccc 14820

cgacatcgtc ctgctgcccg gctgcggcgt ggacttcacc gagagccgcc tcagcaacct 14880

gctgggcatc cgcaagcggc agcccttcca ggagggcttc cagatcctgt acgaggacct 14940

ggaggggggc aacatccccg cgctcttgga tgtcgaagcc tatgaagaaa gtaaggaaaa 15000

agcagaggct gaggcaacta cagccgtggc taccgccgcg actgtggcag atgccactgt 15060

caccaggggc gatacattcg ccacccaggc ggaggaagca gccgccctag cggcgaccga 15120

tgatagtgaa agtaagatag tcatcaagcc ggtggagaag gacagcaaga acaggagcta 15180

caacgttcta ccggatggaa agaacaccgc ctaccgcagc tggtacctgg cctacaacta 15240

cggcgacccc gagaagggcg tgcgctcctg gacgctgctc accacctcgg acgtcacctg 15300

cggcgtggag caagtctact ggtcgctgcc cgacatgatg caagacccgg tcaccttccg 15360

ctccacgcga caagttagca actacccggt ggtgggcgcc gagctcctgc ccgtctactc 15420

caagagcttc ttcaacgagc aggccgtcta ctcgcagcag ctgcgtgcct tcacctcgct 15480

cacgcacgtc ttcaaccgct tccccgagaa ccagatcctc gtccgcccgc ccgcgcccac 15540

cattaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggaccc tgccgctgcg 15600

cagcagtatc cggggagtcc agcgcgtgac cgtcactgac gccagacgcc gcacctgccc 15660

ctacgtctac aaggccctgg gcgtagtcgc gccgcgcgtc ctctcgagcc gcaccttcta 15720

aaaaatgtcc attctcatct cgcccagtaa taacaccggt tggggcctgc gcgcgcccag 15780

caagatgtac ggaggcgctc gccaacgctc cacgcaacac cccgtgcgcg tgcgcgggca 15840

cttccgcgct ccctggggcg ccctcaaggg ccgcgtgcgc tcgcgcacca ccgtcgacga 15900

cgtgatcgac caggtggtgg ccgacgcgcg caactacacg cccgccgccg cgcccgcctc 15960

caccgtggac gccgtcatcg acagcgtggt ggccgacgcg cgccggtacg cccgcgccaa 16020

gagccggcgg cggcgcatcg cccggcggca ccggagcacc cccgccatgc gcgcggcgcg 16080

agccttgctg cgcagggcca ggcgcacggg acgcagggcc atgctcaggg cggccagacg 16140

cgcggcctcc ggcagcagca gcgccggcag gacccgcaga cgcgcggcca cggcggcggc 16200

ggcggccatc gccagcatgt cccgcccgcg gcgcggcaac gtgtactggg tgcgcgacgc 16260

cgccaccggt gtgcgcgtgc ccgtgcgcac ccgcccccct cgcacttgaa gatgctgact 16320

tcgcgatgtt gatgtgtccc agcggcgagg aggatgtcca agcgcaaata caaggaagag 16380

atgctccagg tcatcgcgcc tgagatctac ggccccgcgg cggcggtgaa ggaggaaaga 16440

aagccccgca aactgaagcg ggtcaaaaag gacaaaaagg aggaggaaga tgacggactg 16500

gtggagtttg tgcgcgagtt cgccccccgg cggcgcgtgc agtggcgcgg gcggaaagtg 16560

aaaccggtgc tgcggcccgg caccacggtg gtcttcacgc ccggcgagcg ttccggctcc 16620

gcctccaagc gctcctacga cgaggtgtac ggggacgagg acatcctcga gcaggcggtc 16680

gagcgtctgg gcgagtttgc ttacggcaag cgcagccgcc ccgcgccctt gaaagaggag 16740

gcggtgtcca tcccgctgga ccacggcaac cccacgccga gcctgaagcc ggtgaccctg 16800

cagcaggtgc tgccgagcgc ggcgccgcgc cggggcttca agcgcgaggg cggcgaggat 16860

ctgtacccga ccatgcagct gatggtgccc aagcgccaga agctggagga cgtgctggag 16920

cacatgaagg tggaccccga ggtgcagccc gaggtcaagg tgcggcccat caagcaggtg 16980

gccccgggcc tgggcgtgca gaccgtggac atcaagatcc ccacggagcc catggaaacg 17040

cagaccgagc ccgtgaagcc cagcaccagc accatggagg tgcagacgga tccctggatg 17100

ccagcggctt ccaccaccac cactcgccga agacgcaagt acggcgcggc cagcctgctg 17160

atgcccaact acgcgctgca tccttccatc atccccacgc cgggctaccg cggcacgcgc 17220

ttctaccgcg gctacaccag cagccgccgc cgcaagacca ccacccgccg ccgtcgtcgc 17280

agccgccgca gcagcaccgc gacttccgcc ttggtgcgga gagtgtatcg cagcgggcgc 17340

gagcctctga ccctgccgcg cgcgcgctac cacccgagca tcgccattta actaccgcct 17400

cctacttgca gatatggccc tcacatgccg cctccgcgtc cccattacgg gctaccgagg 17460

aagaaagccg cgccgtagaa ggctgacggg gaacgggctg cgtcgccatc accaccggcg 17520

gcggcgcgcc atcagcaagc ggttgggggg aggcttcctg cccgcgctga tccccatcat 17580

cgccgcggcg atcggggcga tccccggcat agcttccgtg gcggtgcagg cctctcagcg 17640

ccactgagac acaaaaaagc atggatttgt aataaaaaaa tggactgacg ctcctggtcc 17700

tgtgatgtgt gtttttagat ggaagacatc aatttttcgt ccctggcacc gcgacacggc 17760

acgcggccgt ttatgggcac ctggagcgac atcggcaaca gccaactgaa cgggggcgcc 17820

ttcaattgga gcagtctctg gagcgggctt aagaatttcg ggtccacgct caaaacctat 17880

ggcaacaagg cgtggaacag cagcacaggg caggcgctga gggaaaagct gaaagagcag 17940

aacttccagc agaaggtggt cgatggcctg gcctcgggca tcaacggggt ggtggacctg 18000

gccaaccagg ccgtgcagaa acagatcaac agccgcctgg acgcggtccc gcccgcgggg 18060

tccgtggaga tgccccaggt ggaggaggag ctgcctcccc tggacaagcg cggcgacaag 18120

cgaccgcgtc ccgacgcgga ggagacgctg ctgacgcaca cggacgagcc gcccccgtac 18180

gaggaggcgg tgaaactggg tctgcccacc acgcggcccg tggcgcctct ggccaccggg 18240

gtgctgaaac ccagcagcag cagccagccc gcgaccctgg acttgcctcc gcctgcttcc 18300

cgcccctcca cagtggctaa gcccctgccg ccggtggccg tcgcgtcgcg cgccccccga 18360

ggccgccccc aggcgaactg gcagagcact ctgaacagca tcgtgggtct gggagtgcag 18420

agtgtgaagc gccgccgctg ctattaaaag acactgtagc gcttaacttg cttgtctgtg 18480

tgtgtatatg tatgtccgcc gaccagaagg aggaagaggc gcgtcgccga gttgcaagat 18540

ggccacccca tcgatgctgc cccagtgggc gtacatgcac atcgccggac aggacgcttc 18600

ggagtacctg agtccgggtc tggtgcagtt cgcccgcgcc acagacacct acttcagtct 18660

ggggaacaag tttaggaacc ccacggtggc gcccacgcac gatgtgacca ccgaccgcag 18720

ccagcggctg acgctgcgct tcgtgcccgt ggaccgcgag gacaacacct actcgtacaa 18780

agtgcgctac acgctggccg tgggcgacaa ccgcgtgctg gacatggcca gcacctactt 18840

tgacatccgc ggcgtgctgg atcggggccc cagcttcaaa ccctactccg gcaccgccta 18900

caacagccta gctcccaagg gagcgcccaa cacctcacag tggaaggatt ccgacagcaa 18960

aatgcatact tttggagttg ctgccatgcc cggtgttgtt ggtaaaaaaa tagaagccga 19020

tggtctgcct attggaatag attcatcctc tggaactgac accataattt atgctgataa 19080

aactttccaa ccagagccac aggttggaag tgacagttgg gtcgacacca atggtgcaga 19140

ggaaaaatat ggaggtagag ctcttaagga cactacaaac atgaagccct gctacggttc 19200

ttttgccagg cctaccaaca aagaaggtgg acaggctaac ataaaagatt ctgaaactgc 19260

cagcactact cctaactatg atatagattt ggcattcttt gacagcaaaa atattgcagc 19320

taactacgat ccagatattg taatgtacac agaaaatgtt gagttgcaaa ctccagatac 19380

tcatattgtg tttaagccag gaacttcaga tgaaagttca gaagccaatt tgggccagca 19440

ggccatgccc aacagaccca actacatcgg gttcagagac aactttatcg ggctcatgta 19500

ctacaacagc actggcaata tgggtgtact ggctggtcag gcctcccagc taaatgctgt 19560

ggtggacttg caggacagaa acaccgaact gtcctaccag ctcttgcttg actctctggg 19620

tgacagaacc aggtatttca gtatgtggaa tcaggcggtg gacagctatg accccgatgt 19680

gcgcattatt gaaaatcacg gtgtggagga tgaactcccc aattattgct tccctttgaa 19740

tggtgtaggc tttacagata cttaccaggg tgttaaagtt aagacagata cagccgctac 19800

tggtaccaat ggaacgcagt gggacaaaga tgataccaca gtcagcactg ccaatgagat 19860

ccactcaggc aatcctttcg ccatggagat caacatccag gccaacctgt ggcggaactt 19920

cctctacgcg aacgtggcgc tgtacctgcc cgactcctac aagtacacgc cggccaacat 19980

cacgctgccg accaacacca acacctacga ttacatgaac ggccgcgtgg tggcgccctc 20040

gctggtggac gcctacatca acatcggggc gcgctggtcg ctggacccca tggacaacgt 20100

caaccccttc aaccaccacc gcaacgcggg cctgcgctac cgctccatgc tcctgggcaa 20160

cgggcgctac gtgcccttcc acatccaggt gccccaaaag tttttcgcca tcaagagcct 20220

cctgctcctg cccgggtcct acacctacga gtggaacttc cgcaaggacg tcaacatgat 20280

cctgcagagc tccctcggca acgacctgcg cacggacggg gcctccatcg ccttcaccag 20340

catcaacctc tacgccacct tcttccccat ggcgcacaac accgcctcca cgctcgaggc 20400

catgctgcgc aacgacacca acgaccagtc cttcaacgac tacctctcgg cggccaacat 20460

gctctacccc atcccggcca acgccaccaa cgtgcccatc tccatcccct cgcgcaactg 20520

ggccgccttc cgcggatggt ccttcacgcg cctcaagacc cgcgagacgc cctcgctcgg 20580

ctccgggttc gacccctact tcgtctactc gggctccatc ccctacctcg acggcacctt 20640

ctacctcaac cacaccttca agaaggtctc catcaccttc gactcctccg tcagctggcc 20700

cggcaacgac cgcctcctga cgcccaacga gttcgaaatc aagcgcaccg tcgacggaga 20760

gggatacaac gtggcccagt gcaacatgac caaggactgg ttcctggtcc agatgctggc 20820

ccactacaac atcggctacc agggcttcta cgtgcccgag ggctacaagg accgcatgta 20880

ctccttcttc cgcaacttcc agcccatgag ccgccaggtc gtggacgagg tcaactacaa 20940

ggactaccag gccgtcaccc tggcctacca gcacaacaac tcgggcttcg tcggctacct 21000

cgcgcccacc atgcgccagg gccagcccta ccccgccaac tacccctacc cgctcatcgg 21060

caagagcgcc gtcgccagcg tcacccagaa aaagttcctc tgcgaccggg tcatgtggcg 21120

catccccttc tccagcaact tcatgtccat gggcgcgctc accgacctcg gccagaacat 21180

gctctacgcc aactccgccc acgcgctaga catgaatttc gaagtcgacc ccatggatga 21240

gtccaccctt ctctatgttg tcttcgaagt cttcgacgtc gtccgagtgc accagcccca 21300

ccgcggcgtc atcgaggccg tctacctgcg cacgcccttc tcggccggca acgccaccac 21360

ctaaagcccc gctcttgctt cttgcaagat gacggcctgt ggctccggcg agcaggagct 21420

cagggccatc ctccgcgacc tgggctgcgg gccctgcttc ctgggcacct tcgacaagcg 21480

cttcccggga ttcatggccc cgcacaagct ggcctgcgcc atcgtcaaca cggccggccg 21540

cgagaccggg ggcgagcact ggctggcctt cgcctggaac ccgcgctccc acacctgcta 21600

cctcttcgac cccttcgggt tctcggacga gcgcctcaag cagatctacc agttcgagta 21660

cgagggcctg ctgcgccgca gcgccctggc caccgaggac cgctgcatca ccctggaaaa 21720

gtccacccag accgtgcagg gtccgcgctc ggccgcctgc gggctcttct gctgcatgtt 21780

cctgcacgcc ttcgtgcact ggcccgaccg ccccatggac aagaacccca ccatgaactt 21840

gctgacgggg gtgcccaacg gcatgctcca gtcgccccag gtggaaccca ccctgcgccg 21900

caaccaggag gcgctctacc gcttcctcaa cgcccactcc gcctactttc gctcccaccg 21960

cgcgcgcatc gagaaggcca ccgccttcga ccgcatgaat caagacatgt aaactgtgtg 22020

tatgtgaatg ctttattcat cataataaac agcacatgtt tatgccacct tctctgaggc 22080

tctgacttta tttagaaatc gaaggggttc tgccggctct cggcgtgccc cgcgggcagg 22140

gatacgttgc ggaactggta cttgggcagc cacttgaact cggggatcag cagcttcggc 22200

acggggaggt cggggaacga gtcgctccac agcttgcgcg tgagttgcag ggcgcccagc 22260

aggtcgggcg cggagatctt gaaatcgcag ttgggacccg cgttctgcgc gcgagagttg 22320

cggtacacgg ggttgcagca ctggaacacc atcagggccg ggtgcttcac gctcgccagc 22380

accgtcgcgt cggtgatgcc ctccacgtcc agatcctcgg cgttggccat cccgaagggg 22440

gtcatcttgc aggtctgccg ccccatgctg ggcacgcagc cgggcttgtg gttgcaatcg 22500

cagtgcaggg ggatcagcat catctgagcc tgctcggagc tcatgcccgg gtacatggcc 22560

ttcatgaaag cctccagctg gcggaaggcc tgctgcgcct tgccgccctc ggtgaagaag 22620

accccacagg acttgctaga gaactggttg gtggcgcagc ccgcgtcgtg cacgcagcag 22680

cgcgcgtcgt tgttggccag ctgcaccacg ctgcgccccc agcggttctg ggtgatcttg 22740

gcccggtcgg ggttctcctt cagcgcgcgc tgcccgttct cgctcgccac atccatctcg 22800

atcgtgtgct ccttctggat catcacggtc ccgtgcaggc accgcagctt gccctcggcc 22860

tcggtgcacc cgtgcagcca cagcgcgcag ccggtgcact cccagttctt gtgggcgatc 22920

tgggagtgcg agtgcacgaa gccctgcagg aagcggccca tcatcgtggt cagggtcttg 22980

ttgctggtga aggtcagcgg gatgccgcgg tgctcctcgt tcacatacag gtggcagatg 23040

cggcggtaca cctcgccctg ctcgggcatc agctggaagg cggacttcag gtcgctctcc 23100

acgcggtacc gctccatcag cagcgtcatc acttccatgc ccttctccca ggccgaaacg 23160

atcggcaggc tcagggggtt cttcaccgtc atcttagtcg ccgccgccga agtcagggggg 23220

tcgttctcgt ccagggtctc aaacactcgc ttgccgtcct tctcggtgat gcgcacgggg 23280

ggaaagctga agcccacggc cgccagctcc tcctcggcct gcctttcgtc ctcgctgtcc 23340

tggctgatgt cttgcaaagg cacatgcttg gtcttgcggg gtttcttttt gggcggcaga 23400

ggcggcggcg gagacgtgct gggcgagcgc gagttctcgc tcaccacgac tatttcttct 23460

tcttggccgt cgtccgagac cacgcggcgg taggcatgcc tcttctgggg cagaggcgga 23520

ggcgacgggc tctcgcggtt cggcgggcgg ctggcagagc cccttccgcg ttcgggggtg 23580

cgctcctggc ggcgctgctc tgactgactt cctccgcggc cggccattgt gttctcctag 23640

ggagcaacaa gcatggagac tcagccatcg tcgccaacat cgccatctgc ccccgccgcc 23700

gacgagaacc agcagcagca gaatgaaagc ttaaccgccc cgccgcccag ccccacctcc 23760

gacgccgccg cggccccaga catgcaagag atggaggaat ccatcgagat tgacctgggc 23820

tacgtgacgc ccgcggagca cgaggaggag ctggcagcgc gcttttcagc cccggaagag 23880

aaccaccaag agcagccaga gcaggaagca gagagcgagc agcagcaggc tgggctcgag 23940

catggcgact acctgagcgg ggcagaggac gtgctcatca agcatctggc ccgccaaagc 24000

atcatcgtca aggacgcgct gctcgaccgc gccgaggtgc ccctcagcgt ggcggagctc 24060

agccgcgcct acgagcgcaa cctcttctcg ccgcgcgtgc cccccaagcg ccagcccaac 24120

ggcacctgcg agcccaaccc gcgcctcaac ttctacccgg tcttcgcggt gcccgaggcc 24180

ctggccacct accacctctt tttcaagaac caaaggatcc ccgtctcctg ccgcgccaac 24240

cgcacccgcg ccgacgccct gctcaacctg ggtcccggcg cccgcctacc tgatatcacc 24300

tccttggaag aggttcccaa gatcttcgag ggtctgggca gcgacgagac tcgggccgcg 24360

aacgctctgc aaggaagcgg agaggagcat gagcaccaca gcgccctggt ggagttggaa 24420

ggcgacaacg cgcgcctggc ggtgctcaag cgcacggtcg agctgaccca cttcgcctac 24480

ccggcgctca acctgccccc caaggtcatg agcgccgtca tggaccaggt gctcatcaag 24540

cgcgcctcgc ccctctcaga ggaggagatg caggaccccg agagctcgga cgagggcaag 24600

cccgtggtca gcgacgagca gctggcgcgc tggctgggag cgagcagcac cccccagagc 24660

ctggaagagc ggcgcaagct catgatggcc gtggtcctgg tgaccgtgga gctggagtgt 24720

ctgcgccgct tcttcgccga cgcggagacc ctgcgcaagg tcgaggagaa cctgcactac 24780

ctcttcaggc acgggttcgt gcgccaggcc tgcaagatct ccaacgtgga gctgaccaac 24840

ctggtctcct acatgggcat cctgcacgag aaccgcctgg ggcagaacgt gctgcacacc 24900

accctgcgcg gggaggcccg ccgcgactac atccgcgact gcgtctacct gtacctctgc 24960

cacacctggc agacgggcat gggcgtgtgg cagcagtgcc tggaggagca gaacctgaaa 25020

gagctctgca agctcctgca gaagaacctc aaggccctgt ggaccgggtt cgacgagcgc 25080

accaccgcct cggacctggc cgacctcatc ttccccgagc gcctgcggct gacgctgcgc 25140

aacgggctgc ccgactttat gagccaaagc atgttgcaaa actttcgctc tttcatcctc 25200

gaacgctccg ggatcctgcc cgccacctgc tccgcactgc cctcggactt cgtgccgctg 25260

accttccgcg agtgcccccc gccgctctgg agccactgct acttgctgcg cctggccaac 25320

tacctggcct accactcgga cgtgatcgag gacgtcagca gcgagggtct gctcgagtgc 25380

cactgccgct gcaacctctg cacgccgcac cgctccttgg cctgcaaccc ccagctgctg 25440

agcgagaccc agatcatcgg caccttcgag ttgcaaggcc ccggcgaggg caaggggggt 25500

ctcaaactca ccccggggct gtggacctcg gcctacttgc gcaagttcgt gcccgaggac 25560

taccatccct tcgagatcag gttctacgag gaccaatccc agccgcccaa ggccgagctg 25620

tcggcctgcg tcatcaccca gggggccatc ctggcccaat tgcaagccat ccagaaatcc 25680

cgccaagaat ttctgctgaa aaagggccac ggggtctact tggaccccca gaccggagag 25740

gagctcaacc ccagcttccc ccaggatgcc ccgaggaagc agcaagaagc tgaaagtgga 25800

gctgccgctg ccgccggagg atttggagga agactgggag agcagtcagg cagaggagat 25860

ggaagactgg gacagcactc aggcagagga ggacagcctg caagacagtc tggaggagga 25920

agacgaggtg gaggaggagg cagaggaaga agcagccgcc gccagaccgt cgtcctcggc 25980

ggaggagaaa gcaagcagca cggataccat ctccgctccg ggtcggggtc gcggcggccg 26040

ggcccacagt agatgggacg agaccgggcg cttcccgaac cccaccaccc agaccggtaa 26100

gaaggagcgg cagggataca agtcctggcg ggggcacaaa aacgccatcg tctcctgctt 26160

gcaagcctgc gggggcaaca tctccttcac ccggcgctac ctgctcttcc accgcggggt 26220

gaacttcccc cgcaacatct tgcattacta ccgtcacctc cacagcccct actactgttt 26280

ccaagaagag gcagaaaccc agcagcagca gcagaaaacc agcggcagca gcagcagcta 26340

gaaaatccac agcggcggca ggtggactga ggatcgcggc gaacgagccg gcgcagaccc 26400

gggagctgag gaaccggatc tttcccaccc tctatgccat cttccagcag agtcgggggc 26460

aggagcagga actgaaagtc aagaaccgtt ctctgcgctc gctcacccgc agttgtctgt 26520

atcacaagag cgaagaccaa cttcagcgca ctctcgagga cgccgaggct ctcttcaaca 26580

agtactgcgc gctcactctt aaagagtagc ccgcgcccgc ccacacacgg aaaaaggcgg 26640

gaattacgtc accacctgcg cccttcgccc gaccatcatc atgagcaaag agattcccac 26700

gccttacatg tggagctacc agccccagat gggcctggcc gccggcgccg cccaggacta 26760

ctccacccgc atgaactggc tcagtgccgg gcccgcgatg atctcacggg tgaatgacat 26820

ccgcgcccac cgaaaccaga tactcctaga acagtcagcg atcaccgcca cgccccgcca 26880

tcaccttaat ccgcgtaatt ggcccgccgc cctggtgtac caggaaattc cccagcccac 26940

gaccgtacta cttccgcgag acgcccaggc cgaagtccag ctgactaact caggtgtcca 27000

gctggccggc ggcgccgccc tgtgtcgtca ccgccccgct cagggtataa agcggctggt 27060

gatccgaggc agaggcacac agctcaacga cgaggtggtg agctcttcgc tgggtctgcg 27120

acctgacgga gtcttccaac tcgccggatc ggggagatct tccttcacgc ctcgtcaggc 27180

cgtcctgact ttggagagtt cgtcctcgca gccccgctcg ggcggcatcg gcactctcca 27240

gttcgtggag gagttcactc cctcggtcta cttcaacccc ttctccggct cccccggcca 27300

ctacccggac gagttcatcc cgaacttcga cgccatcagc gagtcggtgg acggctacga 27360

ttgaatgtcc catggtggcg cggctgacct agctcggctt cgacacctgg accactgccg 27420

ccgcttccgc tgcttcgctc gggatctcgc cgagtttgcc tactttgagc tgcccgagga 27480

gcaccctcag ggcccggccc acggagtgcg gatcgtcgtc gaagggggcc tcgactccca 27540

cctgcttcgg attttcagcc agcgtccgat cctggtcgag cgcgagcaag gacagaccct 27600

tctgaccctg tactgcatct gcaaccaccc cggcctgcat gaaagtcttt gttgtctgct 27660

gtgtactgag tataataaaa gctgagatca gcgactactc cggactcgat tgtggtgttc 27720

ctgctatcaa ccggtccctg ttcttcaccg ggaacgagac cgagctccag ctccagtgta 27780

agccccacaa gaagtatctc acctggctgt tccagggctc tccgatcgcc gttgtcaacc 27840

actgcgacaa cgacggagtc ctgctgagcg gccctgccaa ccttactttt tccacccgca 27900

gaagcaagct ccagctcttc caacccttcc tccccgggac ctatcagtgc gtctcgggac 27960

cctgccatca caccttccac ctgatcccga ataccacagc gccgctcccc gctactaaca 28020

accaaactac ccaccaacgc caccgtcgcg acctttctga atctaatact accacccaca 28080

ccggaggtga gctccgaggt cgaccaacct ctgggattta ctacggggtt aaccccttaa 28140

ttaaggggat tccatatggt acgtacatcg cctctcctac gagctcctgc agcagcgcca 28200

gaagttcacc tgcctggtcg gagtcaaccc catcgtcatc acccagcagt cgggcgatac 28260

caaggggtgc atccactgct cctgcgactc ccccgactgc gtccacactc tgatcaagac 28320

cctctgcggc ctccgcgacc tcctccccat gaactaatca cccccttatc cagtgaaata 28380

aagatcatat tgatgatgat tttacagaaa taaagataca atcatattga tgatttgagt 28440

ttaataaaaa ataaagaatc acttacttga aatctgatac caggtctctg tccatgtttt 28500

ctgccaacac cacttcactc ccctcttccc agctctggta ctgcaggccc cggcgggctg 28560

caaacttcct ccacacgctg aaggggatgt caaattcctc ctgtccctca atcttcattt 28620

tatcttctat cagatgtcca aaaagcgcgt ccgggtggat gatgacttcg accccgtcta 28680

cccctacgat gcagacaacg caccgaccgt gcccttcatc aaccccccct tcgtctcttc 28740

agatggattc caagagaagc ccctgggggt gctgtccctg cgactggccg accccgtcac 28800

caccaagaac ggggaaatca ccctcaagct gggagagggg gtggacctcg actcctcggg 28860

aaaactcatc tccaacacgg ccaccaaggc cgccgcccct ctcagttttt ccaacaacac 28920

catttccctt aacatggatc acccctttta cactaaagat ggaaaattat ccttacaagt 28980

ttctccacca ttaaatatac tgagaacaag cattctaaac acactagctt taggttttgg 29040

atcaggttta ggactccgtg gctctgcctt ggcagtacag ttagtctctc cacttacatt 29100

tgatactgat ggaaacataa agcttacctt agacagaggt ttgcatgtta caacaggaga 29160

tgcaattgaa agcaacataa gctgggctaa aggtttaaaa tttgaagatg gagccatagc 29220

aaccaacatt ggaaatgggt tagagtttgg aagcagtagt acagaaacag gtgttgatga 29280

tgcttaccca atccaagtta aacttggatc tggccttagc tttgacagta caggagccat 29340

aatggctggt aacaaagaag acgataaact cactttgtgg acaacacctg atccatcgcc 29400

aaactgtcaa atactcgcag aaaatgatgc aaaactaaca ctttgcttga ctaaatgtgg 29460

tagtcaaata ctggccactg tgtcagtctt agttgtagga agtggaaacc taaaccccat 29520

tactggcacc gtaagcagtg ctcaggtgtt tctacgtttt gatgcaaacg gtgttctttt 29580

aacagaacat tctacactaa aaaaatactg ggggtatagg cagggagata gcatagatgg 29640

cactccatat accaatgctg taggattcat gcccaattta aaagcttatc caaagtcaca 29700

aagttctact actaaaaata atatagtagg gcaagtatac atgaatggag atgtttcaaa 29760

acctatgctt ctcactataa ccctcaatgg tactgatgac agcaacagta catattcaat 29820

gtcattttca tacacctgga ctaatggaag ctatgttgga gcaacatttg gggctaactc 29880

ttataccttc tcatacatcg cccaagaatg aacactgtat cccaccctgc atgccaaccc 29940

ttcccacccc actctgtgga aaaaactctg aaacacaaaa taaaataaag ttcaagtgtt 30000

ttattgattc aacagtttta caggattcga gcagttattt ttcctccacc ctcccaggac 30060

atggaataca ccaccctctc cccccgcaca gccttgaaca tctgaacgcc attggtgatg 30120

gacatgcttt tggtctccac gttccacaca gtttcagagc gagccagtct cgggtcggtc 30180

agggagatga aaccctccgg gcacaattgg gagaagtact cgcctattat ctggaagaag 30240

cagaagagcg gcggtgggaa tcatagtccg cgaacgggat cggccggtgg tgtcgcatca 30300

ggccccgcag cagtcgctgc cgccgccgct ccgtcaagct gctgctcagg gggtccgggt 30360

ccagggactc cctcagcatg atgcccacgg ccctcagcat cagtcgtctg gtgcggcggg 30420

cgcagcagcg catgcggatc tcgctcaggt cgctgcagta cgtgcaacac agaaccacca 30480

ggttgttcaa cagtccatag ttcaacacgc tccagccgaa actcatcgcg ggaaggatgc 30540

tacccacgtg gccgtcgtac cagatcctca ggtaaatcaa gtggtgcccc ctccagaaca 30600

cgctgcccac gtacatgatc tccttgggca tgtggcggtt caccacctcc cggtaccaca 30660

tcaccctctg gttgaacatg cagccccgga tgatcctgcg gaaccacagg gccagcaccg 30720

ccccgcccgc catgcagcga agagaccccg ggtcccggca atggcaatgg aggacccacc 30780

gctcgtaccc gtggatcatc tgggagctga acaagtctat gttggcacag cacaggcata 30840

tgctcatgca tctcttcagc actctcaact cctcgggggt caaaaccata tcccagggca 30900

cggggaactc ttgcaggaca gcgaaccccg cagaacaggg caatcctcgc acagaactta 30960

cattgtgcat ggacagggta tcgcaatcag gcagcaccgg gtgatcctcc accagagaag 31020

cgcgggtctc ggtctcctca cagcgtggta agggggccgg ccgatacggg tgatggcggg 31080

acgcggctga tcgtgttcgc gaccgtgtca tgatgcagtt gctttcggac atatttcctg 31140

aagtcttggc gcgccaaagt ctagacagcg tccatagctt accgagcagc agcagcagca 31200

cacaacaggc gcaagagtca gagaaaggct gagctctaac ctgtccaccc gctctctgct 31260

caatatatag cccagatcta cactgacgta aaggccaaag tctaaaaata cccgccaaat 31320

agtcacacac gcccagcaca cgcccagaaa ccggtgacac actcaaaaaa atacgcgcac 31380

ttcctcaaac gcccaaactg ccgtcatttc cgggttccca cgctacgtca tcaaaacacg 31440

actttcaaat tccgtcgacc gttaaaaacg tcacccgccc cgcccctaac ggtcgcccgt 31500

ctctcagcca atcagcgccc cgcatcccca aattcaaaca cctcatttgc atattaacgc 31560

gcaccaaaag tttgaggtat attattgatg atg 31593

<210> 14

<211> 29334

<212> DNA

<213> Artificial Sequence

<400> 14

aaatcatcat caataatata cctcaaactt ttggtgcgcg ttaatatgca aatgaggtgt 60

ttgaatttgg ggatgcgggg cgctgattgg ctgagagacg ggcgaccgtt aggggcgggg 120

cgggtgacgt tttgatgacg tggccgtgag gcggagccgg tttgcaagtt ctcgtgggaa 180

aagtgacgtc aaacgaggtg tggtttgaac acggaaatac tcaattttcc cgcgctctct 240

gacaggaaat gaggtgtttc tgggcggatg caagtgaaaa cgggccattt tcgcgcgaaa 300

actgaatgag gaagtgaaaa tctgagtaat tccgcgttta tggcagggag gagtatttgc 360

cgagggccga gtagactttg accgattacg tgggggtttc gattaccgta tttttcacct 420

aaatttccgc gtacggtgtc aaagtccggt gtttttacgt aggcgtcagc tgatcgccag 480

ggtatttaaa cctgcgctct ctagtcaaga ggccactctt gagtgccagc gagtagagtt 540

ttctcctccg cgccgcgagt cagatctaca ctttgaaagg cgatcgccga tatcatttcc 600

ccgaaaagtg ccacctgacc gtaactataa cggtcctaag gtagcgaaag ctcagatctc 660

ccgatcccct atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt 720

atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta 780

caacaaggca aggcttgacc gacaattgca tgaagaatct gcttagggtt aggcgttttg 840

cgctgcttcg cgatgtacgg gccagatata cgcgttgaat tcatctatgt cgggtgcgga 900

gaaagaggta atgaaatggc attatgggta ttatgggtct gcattaatga atcggccaga 960

tatcgacata tgctggccac cgtacatgtg gcttcccatg ctcgcaagcc ctggcccgag 1020

ttcgagcaca atgtcatgac caggtgcaat atgcatctgg ggtcccggcg atcgcccgag 1080

gcatgttcat gccctaccag tgcaacatgc aatttgtgaa ggtgctgctg gagcccgatg 1140

ccatgtccag agtgagcctg acgggggtgt ttgacatgaa tgtggagctg tggaaaattc 1200

tgagatatga tgaatccaag accaggtgcc gggcctgcga atgcggaggc aagcacgcca 1260

ggcttcagcc cgtgtgtgtg gaggtgacgg aggacctgcg acccgatcat ttggtgttgt 1320

cctgcaacgg gacggagttc ggctccagcg gggaagaatc tgactagagt gagtagtgtt 1380

tgggggtggg tgggagcctg catgatgggc agaatgacta aaatctgtgt ttttctgtgt 1440

gttgcagcag catgagcgga agcgcctcct ttgagggagg ggtattcagc ccttatctga 1500

cggggcgtct cccctcctgg gcgggagtgc gtcagaatgt gatgggatcc acggtggacg 1560

gccggcccgt gcagcccgcg aactcttcaa ccctgaccta cgcgaccctg agctcctcgt 1620

ccgtggacgc agctgccgcc gcagctgctg cttccgccgc cagcgccgtg cgcggaatgg 1680

ccctgggcgc cggctactac agctctctgg tggccaactc gagttccacc aataatcccg 1740

ccagcctgaa cgaggagaag ctgttgctgc tgatggccca gctcgaggcc ctgacccagc 1800

gcctgggcga gctgacccag caggtggctc agctgcaggc ggagacgcgg gccgcggttg 1860

ccacggtgaa aaccaaataa aaaatgaatc aataaataaa cggagacggt tgttgatttt 1920

aacacagagt cttgaatctt tatttgattt ttcgcgcgcg gtaggccctg gaccaccggt 1980

ctcgatcatt gagcacccgg tggatctttt ccaggacccg gtagaggtgg gcttggatgt 2040

tgaggtacat gggcatgagc ccgtcccggg ggtggaggta gctccattgc agggcctcgt 2100

gctcgggggt ggtgttgtaa atcacccagt catagcaggg gcgcagggcg tggtgctgca 2160

cgatgtcttt gaggaggaga ctgatggcca cgggcagccc cttggtgtag gtgttgacga 2220

acctattgag ctgggaggga tgcatgcggg gggagatgag atgcatcttg gcctggatct 2280

tgagattggc gatgttcccg cccagatccc gccgggggtt catgttgtgc aggaccacca 2340

gcacggtgta tccggtgcac ttggggaatt tgtcatgcaa cttggaaggg aaggcgtgaa 2400

agaatttgga gacgcccttg tgaccgccca ggttttccat gcactcatcc atgatgatgg 2460

cgatggggccc gtgggcggcg gcctgggcaa agacgtttcg ggggtcggac acatcgtagt 2520

tgtggtcctg ggtgagctcg tcataggcca ttttaatgaa tttggggcgg agggtacccg 2580

actgggggac aaaggtgccc tcgatcccgg gggcgtagtt cccctcgcag atctgcatct 2640

cccaggcctt gagctcggag ggggggatca tgtccacctg cggggcgatg aaaaaaacgg 2700

tttccggggc gggggagatg agctgcgccg aaagcaggtt ccggagcagc tgggacttgc 2760

cgcagccggt ggggccgtag atgaccccga tgaccggctg caggtggtag ttgagggaga 2820

gacagctgcc gtcctcgcgg aggagggggg ccacctcgtt catcatctcg cgcacatgca 2880

tgttctcgcg cacgagttcc gccaggaggc gctcgccccc cagcgagagg agctcttgca 2940

gcgaggcgaa gtttttcagc ggcttgagcc cgtcggccat gggcattttg gagagggtct 3000

gttgcaagag ttccagacgg tcccaagagct cggtgatgtg ctctagggca tctcgatcca 3060

gcagacctcc tcgtttcgcg ggttggggcg actgcgggag tagggcacca ggcgatgggc 3120

gtccagcgag gccagggtcc ggtccttcca gggtcgcagg gtccgcgtca gcgtggtctc 3180

cgtcacggtg aaggggtgcg cgccgggctg ggcgcttgcg agggtgcgct tcaggctcat 3240

ccggctggtc gagaaccgct cccggtcggc gccctgcgcg tcggccaggt agcaattgag 3300

catgagttcg tagttgagcg cctcggccgc gtggcccttg gcgcggagct tacctttgga 3360

agtgtgtccg cagacgggac agaggaggga cttgagggcg tagagcttgg gggcgaggaa 3420

gacggactcg ggggcgtagg cgtccgcgcc gcagctggcg cagacggtct cgcactccac 3480

gagccaggtg aggtcggggc ggtcggggtc aaaaacgagg tttcctccgt gctttttgat 3540

gcgtttctta cctctggtct ccatgagctc gtgtccccgc tgggtgacaa agaggctgtc 3600

cgtgtccccg tagaccgact ttatgggccg gtcctcgagc ggggtgccgc ggtcctcgtc 3660

gtagaggaac cccgcccact ccgagacgaa ggcccgggtc caggccagca cgaaggaggc 3720

cacgtgggag gggtagcggt cgttgtccac cagcgggtcc accttctcca gggtatgcaa 3780

gcacatgtcc ccctcgtcca catccaggaa ggtgattggc ttgtaagtgt aggccacgtg 3840

accgggggtc ccggccgggg gggtataaaa gggggcgggc ccctgctcgt cctcactgtc 3900

ttccggatcg ctgtccagga gcgccagctg ttggggtagg tattccctct cgaaggcggg 3960

catgacctcg gcactcaggt tgtcagtttc tagaaacgag gaggatttga tattgacggt 4020

gccgttggag acgcctttca tgagcccctc gtccatctgg tcagaaaaga cgatcttttt 4080

gttgtcgagc ttggtggcga aggagccgta gagggcgttg gagagcagct tggcgatgga 4140

gcgcatggtc tggttctttt ccttgtcggc gcgctccttg gcggcgatgt tgagctgcac 4200

gtactcgcgc gccacgcact tccattcggg gaagacggtg gtgagctcgt cgggcacgat 4260

tctgacccgc cagccgcggt tgtgcagggt gatgaggtcc acgctggtgg ccacctcgcc 4320

gcgcaggggc tcgttggtcc agcagaggcg cccgcccttg cgcgagcaga aggggggcag 4380

cgggtccagc atgagctcgt cgggggggtc ggcgtccacg gtgaagatgc cgggcaggag 4440

ctcggggtcg aagtagctga tgcaggtgcc cagatcgtcc agacttgctt gccagtcgcg 4500

cacggccagc gcgcgctcgt aggggctgag gggcgtgccc cagggcatgg ggtgcgtgag 4560

cgcggaggcg tacatgccgc agatgtcgta gacgtagagg ggctcctgga ggacgccgat 4620

gtaggtgggg tagcagcgcc ccccgcggat gctggcgcgc acgtagtcgt acagctcgtg 4680

cgagggcgcg aggagccccg tgccgagatt ggagcgctgc ggcttttcgg cgcggtagac 4740

gatctggcgg aagatggcgt gggagttgga ggagatggtg ggcctctgga agatgttgaa 4800

gtgggcatgg ggcagtccga ccgagtccct gatgaagtgg gcgtaggagt cctgcagctt 4860

ggcgacgagc tcggcggtga cgaggacgtc cagggcgcag tagtcgaggg tctcttggat 4920

gatgtcgtac ttgagctggc ccttctgctt ccacagctcg cggttgagaa ggaactcttc 4980

gcggtccttc cagtactctt cgagggggaa cccgtcctga tcggcacggt aagagcccac 5040

catgtagaac tggttgacgg ccttgtaggc gcagcagccc ttctccacgg ggagggcgta 5100

agcttgcgcg gccttgcgca gggaggtgtg ggtgagggcg aaggtgtcgc gcaccatgac 5160

tttgaggaac tggtgcttga agtcgaggtc gtcgcagccg ccctgctccc agagctggaa 5220

gtccgtgcgc ttcttgtagg cggggttggg caaagcgaaa gtaacatcgt tgaagaggat 5280

cttgcccgcg cggggcatga agttgcgagt gatgcggaaa ggctggggca cctcggcccg 5340

gttgttgatg acctgggcgg cgaggacgat ctcgtcgaag ccgttgatgt tgtgcccgac 5400

gatgtagagt tccacgaatc gcgggcggcc cttgacgtgg ggcagcttct tgagctcgtc 5460

gtaggtgagc tcggcggggt cgctgagccc gtgctgctcg agggcccagt cggcgacgtg 5520

ggggttggcg ctgaggaagg aagtccagag atccacggcc agggcggtct gcaagcggtc 5580

ccggtactga cggaactgct ggcccacggc cattttttcg ggggtgacgc agtagaaggt 5640

gcgggggtcg ccgtgccagc ggtcccactt gagctggagg gcgaggtcgt gggcgagctc 5700

gacgagcggc gggtccccgg agagtttcat gaccagcatg aaggggacga gctgcttgcc 5760

gaaggacccc atccaggtgt aggtttccac atcgtaggtg aggaagagcc tttcggtgcg 5820

aggatgcgag ccgatgggga agaactggat ctcctgccac cagttggagg aatggctgtt 5880

gatgtgatgg aagtagaaat gccgacggcg cgccgagcac tcgtgcttgt gtttatacaa 5940

gcgtccgcag tgctcgcaac gctgcacggg atgcacgtgc tgcacgagct gtacctgggt 6000

tcctttgacg aggaatttca gtgggcagtg gagcgctggc ggctgcatct ggtgctgtac 6060

tacgtcctgg ccatcggcgt ggccatcgtc tgcctcgatg gtggtcatgc tgacgagccc 6120

gcgcgggagg caggtccaga cctcggctcg gacgggtcgg agagcgagga cgagggcgcg 6180

caggccggag ctgtccaggg tcctgagacg ctgcggagtc aggtcagtgg gcagcggcgg 6240

cgcgcggttg acttgcagga gcttttccag ggcgcgcggg aggtccagat ggtacttgat 6300

ctccacggcg ccgttggtgg cgacgtccac ggcttgcagg gtcccgtgcc cctggggcgc 6360

caccaccgtg ccccgtttct tcttgggcgg cggcggctcc atgcttagaa gcggcggcga 6420

ggacgcgcgc cgggcggcag gggcggctcg gggcccggag gcaggggcgg caggggcacg 6480

tcggcgccgc gcgcgggcag gttctggtac tgcgcccgga gaagactggc gtgagcgacg 6540

acgcgacggt tgacgtcctg gatctgacgc ctctgggtga aggccacggg acccgtgagt 6600

ttgaacctga aagagagttc gacagaatca atctcggtat cgttgacggc ggcctgccgc 6660

aggatctctt gcacgtcgcc cgagttgtcc tggtaggcga tctcggtcat gaactgctcg 6720

atctcctcct cctgaaggtc tccgcggccg gcgcgctcga cggtggccgc gaggtcgttg 6780

gagatgcggc ccatgagctg cgagaaggcg ttcatgccgg cctcgttcca gacgcggctg 6840

tagaccacgg ctccgtcggg gtcgcgcgcg cgcatgacca cctgggcgag gttgagctcg 6900

acgtggcgcg tgaagaccgc gtagttgcag aggcgctggt agaggtagtt gagcgtggtg 6960

gcgatgtgct cggtgacgaa gaagtacatg atccagcggc ggagcggcat ctcgctgacg 7020

tcgcccaggg cttccaagcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac 7080

tgggagttgc gcgccgagac ggtcaactcc tcctccagaa gacggatgag ctcggcgatg 7140

gtggcgcgca cctcgcgctc gaaggccccg gggggctcct cttccatttc ctcctcttcc 7200

tcctccacta acatctcttc tacttcctcc tcaggaggcg gcggcggggg aggggccctg 7260

cgtcgccggc ggcgcacggg cagacggtcg atgaagcgct cgatggtctc cccgcgccgg 7320

cgacgcatgg tctcggtgac ggcgcgcccg tcctcgcggg gccgcagcgt gaagacgccg 7380

ccgcgcatct ccaggtggcc gccggggggg tctccgttgg gcagggagag ggcgctgacg 7440

atgcatctta tcaattgacc cgtagggact ccgcgcaagg acctgagcgt ctcgagatcc 7500

acgggatccg aaaaccgctg aacgaaggct tcgagccagt cgcagtcgca aggtaggctg 7560

agcccggttt cttgttcttc gggtatttgg tcgggaggcg ggcgggcgat gctgctggtg 7620

atgaagttga agtaggcggt cctgagacgg cggatggtgg cgaggagcac caggtccttg 7680

ggcccggctt gctggatgcg cagacggtcg gccatgcccc aggcgtggtc ctgacacctg 7740

gcgaggtcct tgtagtagtc ctgcatgagc cgctccacgg gcacctcctc ctcgcccgcg 7800

cggccgtgca tgcgcgtgag cccgaacccg cgctgcggct ggacgagcgc caggtcggcg 7860

acgacgcgct cggcgaggat ggcctgctgg atctgggtga gggtggtctg gaagtcgtcg 7920

aagtcgacga agcggtggta ggctccggtg ttgatggtgt aggagcagtt ggccatgacg 7980

gaccagttga cggtctggtg gccggggcgc acgagctcgt ggtacttgag gcgcgagtag 8040

gcgcgcgtgt cgaagatgta gtcgttgcag gtgcgcacga ggtactggta tccgacgagg 8100

aagtgcggcg gcggctggcg gtagagcggc catcgctcgg tggcgggggc gccgggcgcg 8160

aggtcctcga gcatgaggcg gtggtagccg tagatgtacc tggacatcca ggtgatgccg 8220

gcggcggtgg tggaggcgcg cgggaactcg cggacgcggt tccagatgtt gcgcagcggc 8280

aggaagtagt tcatggtggc cgcggtctgg cccgtgaggc gcgcgcagtc gtggatgctc 8340

tagacatacg ggcaaaaacg aaagcggtca gcggctcgac tccgtggcct ggaggctaag 8400

cgaacgggtt gggctgcgcg tgtaccccgg ttcgaatctc gaatcaggct ggagccgcag 8460

ctaacgtggt actggcactc ccgtctcgac ccaagcctgc taacgaaacc tccaggatac 8520

ggaggcgggt cgtttttttgg ccttggtcgc tggtcatgaa aaactagtaa gcgcggaaag 8580

cggccgcccg cgatggctcg ctgccgtagt ctggagaaag aatcgccagg gttgcgttgc 8640

ggtgtgcccc ggttcgagcc tcagcgctcg gcgccggccg gattccgcgg ctaacgtggg 8700

cgtggctgcc ccgtcgtttc caagacccct tagccagccg acttctccag ttacggagcg 8760

agcccctctt ttttttcttgt gtttttgcca gatgcatccc gtactgcggc agatgcgccc 8820

ccaccctcca ccacaaccgc ccctaccgca gcagcagcaa cagccggcgc ttctgccccc 8880

gccccagcag cagcagccag ccactaccgc ggcggccgcc gtgagcggag ccggcgttca 8940

gtatgacctg gccttggaag agggcgaggg gctggcgcgg ctgggggcgt cgtcgccgga 9000

gcggcacccg cgcgtgcaga tgaaaaggga cgctcgcgag gcctacgtgc ccaagcagaa 9060

cctgttcaga gacaggagcg gcgaggagcc cgaggagatg cgcgcctccc gcttccacgc 9120

ggggcgggag ctgcggcgcg gcctggaccg aaagcgggtg ctgagggacg aggatttcga 9180

ggcggacgag ctgacgggga tcagccccgc gcgcgcgcac gtggccgcgg ccaacctggt 9240

cacggcgtac gagcagaccg tgaaggagga gagcaacttc caaaaatcct tcaacaacca 9300

cgtgcgcacg ctgatcgcgc gcgaggaggt gaccctgggc ctgatgcacc tgtgggacct 9360

gctggaggcc atcgtgcaga accccacgag caagccgctg acggcgcagc tgtttctggt 9420

ggtgcagcac agtcgggaca acgagacgtt cagggaggcg ctgctgaata tcaccgagcc 9480

cgagggccgc tggctcctgg acctggtgaa cattctgcag agcatcgtgg tgcaggagcg 9540

cgggctgccg ctgtccgaga agctggcggc catcaacttc tcggtgctga gcctgggcaa 9600

gtactacgct aggaagatct acaagacccc gtacgtgccc atagacaagg aggtgaagat 9660

cgatgggttt tacatgcgca tgaccctgaa agtgctgacc ctgagcgacg atctgggggt 9720

gtaccgcaac gacaggatgc accgcgcggt gagcgccagc cgccggcgcg agctgagcga 9780

ccaggagctg atgcacagcc tgcagcgggc cctgaccggg gccgggaccg agggggagag 9840

ctactttgac atgggcgcgg acctgcgctg gcagcccagc cgccgggcct tggaagctgc 9900

cggcggcgtg ccctacgtgg aggaggtgga cgatgaggag gaggagggcg agtacctgga 9960

agactgatgg cgcgaccgta tttttgctag atgcagcaac agccaccgcc gccgcctcct 10020

gatcccgcga tgcgggcggc gctgcagagc cagccgtccg gcattaactc ctcggacgat 10080

tggacccagg ccatgcaacg catcatggcg ctgacgaccc gcaatcccga agcctttaga 10140

cagcagcctc aggccaaccg gctctcggcc atcctggagg ccgtggtgcc ctcgcgctcg 10200

aaccccacgc acgagaaggt gctggccatc gtgaacgcgc tggtggagaa caaggccatc 10260

cgcggcgacg aggccgggct ggtgtacaac gcgctgctgg agcgcgtggc ccgctacaac 10320

agcaccaacg tgcagacgaa cctggaccgc atggtgaccg acgtgcgcga ggcggtgtcg 10380

cagcgcgagc ggttccaccg cgagtcgaac ctgggctcca tggtggcgct gaacgccttc 10440

ctgagcacgc agcccgccaa cgtgccccgg ggccaggagg actacaccaa cttcatcagc 10500

gcgctgcggc tgatggtggc cgaggtgccc cagagcgagg tgtaccagtc ggggccggac 10560

tacttcttcc agaccagtcg ccagggcttg cagaccgtga acctgagcca ggctttcaag 10620

aacttgcagg gactgtgggg cgtgcaggcc ccggtcgggg accgcgcgac ggtgtcgagc 10680

ctgctgacgc cgaactcgcg cctgctgctg ctgctggtgg cgcccttcac ggacagcggc 10740

agcgtgagcc gcgactcgta cctgggctac ctgcttaacc tgtaccgcga ggccatcggg 10800

caggcgcacg tggacgagca gacctaccag gagatcaccc acgtgagccg cgcgctgggc 10860

caggaggacc cgggcaacct ggaggccacc ctgaacttcc tgctgaccaa ccggtcgcag 10920

aagatcccgc cccagtacgc gctgagcacc gaggaggagc gcatcctgcg ctacgtgcag 10980

cagagcgtgg ggctgttctt gatgcaggag ggggccacgc ccagcgccgc gctcgacatg 11040

accgcgcgca acatggagcc cagcatgtac gcccgcaacc gcccgttcat caataagctg 11100

atggactact tgcatcgggc ggccgccatg aactcggact actttaccaa cgccatcttg 11160

aacccgcact ggctcccgcc gcccgggttc tacacgggcg agtacgacat gcccgacccc 11220

aacgacgggt tcctgtggga cgacgtggac agcagcgtgt tctcgccgcg gcccaccacc 11280

accaccgtgt ggaagaaaga gggcggggac cggcggccgt cctcggcgct gtccggtcgc 11340

gcgggtgctg ccgcggcggt gcccgaggct gccagcccct tcccgagcct gcccttttcg 11400

ctgaacagcg tgcgcagcag cgagctgggt cggctgacgc ggccgcgcct gctgggcgag 11460

gaggagtacc tgaacgactc cttgttgaag cccgagcgcg agaagaactt ccccaataac 11520

gggatagaga gcctggtgga caagatgagc cgctggaaga cgtacgcgca cgagcacagg 11580

gacgagcccc gagctagcag cgcaggcacc cgtagacgcc agcggcacga caggcagcgg 11640

ggactggtgt gggacgatga ggattccgcc gacgacagca gcgtgttgga cttgggtggg 11700

agtggtggtg gtaacccgtt cgctcacctg cgccccccgta tcgggcgcct gatgtaagaa 11760

tctgaaaaaa taaaagacgg tactcaccaa ggccatggcg accagcgtgc gttcttctct 11820

gttgtttgta gtagtatgat gaggcgcgtg tacccggagg gtcctcctcc ctcgtacgag 11880

agcgtgatgc agcaggcggt ggcggcggcg atgcagcccc cgctggaggc gccttacgtg 11940

cccccgcggt acctggcgcc tacggagggg cggaacagca ttcgttactc ggagctggca 12000

cccttgtacg ataccacccg gttgtacctg gtggacaaca agtcggcgga catcgcctcg 12060

ctgaactacc agaacgacca cagcaacttc ctgaccaccg tggtgcagaa caacgatttc 12120

acccccacgg aggccagcac ccagaccatc aactttgacg agcgctcgcg gtggggcggc 12180

cagctgaaaa ccatcatgca caccaacatg cccaacgtga acgagttcat gtacagcaac 12240

aagttcaagg cgcgggtgat ggtctcgcgc aagaccccca acggggtcac ggtaggggat 12300

gattatgatg gtagtcagga cgagctgacc tacgagtggg tggagtttga gctgcccgag 12360

ggcaacttct cggtgaccat gaccatcgat ctgatgaaca acgccatcat cgacaactac 12420

ttggcggtgg ggcggcagaa cggggtgctg gagagcgaca tcggcgtgaa gttcgacacg 12480

cgcaacttcc ggctgggctg ggaccccgtg accgagctgg tgatgccggg cgtgtacacc 12540

aacgaggcct tccaccccga catcgtcctg ctgcccggct gcggcgtgga cttcaccgag 12600

agccgcctca gcaacctgct gggcatccgc aagcggcagc ccttccagga gggcttccag 12660

atcctgtacg aggacctgga ggggggcaac atccccgcgc tcttggatgt cgaagcctat 12720

gaagaaagta aggaaaaagc agaggctgag gcaactacag ccgtggctac cgccgcgact 12780

gtggcagatg ccactgtcac caggggcgat acattcgcca cccaggcgga ggaagcagcc 12840

gccctagcgg cgaccgatga tagtgaaagt aagatagtca tcaagccggt ggagaaggac 12900

agcaagaaca ggagctacaa cgttctaccg gatggaaaga acaccgccta ccgcagctgg 12960

tacctggcct acaactacgg cgaccccgag aagggcgtgc gctcctggac gctgctcacc 13020

acctcggacg tcacctgcgg cgtggagcaa gtctactggt cgctgcccga catgatgcaa 13080

gacccggtca ccttccgctc cacgcgacaa gttagcaact acccggtggt gggcgccgag 13140

ctcctgcccg tctactccaa gagcttcttc aacgagcagg ccgtctactc gcagcagctg 13200

cgtgccttca cctcgctcac gcacgtcttc aaccgcttcc ccgagaacca gatcctcgtc 13260

cgcccgcccg cgcccaccat taccaccgtc agtgaaaacg ttcctgctct cacagatcac 13320

gggaccctgc cgctgcgcag cagtatccgg ggagtccagc gcgtgaccgt cactgacgcc 13380

agacgccgca cctgccccta cgtctacaag gccctgggcg tagtcgcgcc gcgcgtcctc 13440

tcgagccgca ccttctaaaa aatgtccatt ctcatctcgc ccagtaataa caccggttgg 13500

ggcctgcgcg cgcccagcaa gatgtacgga ggcgctcgcc aacgctccac gcaacacccc 13560

gtgcgcgtgc gcgggcactt ccgcgctccc tggggcgccc tcaagggccg cgtgcgctcg 13620

cgcaccaccg tcgacgacgt gatcgaccag gtggtggccg acgcgcgcaa ctacacgccc 13680

gccgccgcgc ccgcctccac cgtggacgcc gtcatcgaca gcgtggtggc cgacgcgcgc 13740

cggtacgccc gcgccaagag ccggcggcgg cgcatcgccc ggcggcaccg gagcaccccc 13800

gccatgcgcg cggcgcgagc cttgctgcgc agggccaggc gcacgggacg cagggccatg 13860

ctcagggcgg ccagacgcgc ggcctccggc agcagcagcg ccggcaggac ccgcagacgc 13920

gcggccacgg cggcggcggc ggccatcgcc agcatgtccc gcccgcggcg cggcaacgtg 13980

tactgggtgc gcgacgccgc caccggtgtg cgcgtgcccg tgcgcacccg cccccctcgc 14040

acttgaagat gctgacttcg cgatgttgat gtgtcccagc ggcgaggagg atgtccaagc 14100

gcaaatacaa ggaagagatg ctccaggtca tcgcgcctga gatctacggc cccgcggcgg 14160

cggtgaagga ggaaagaaag ccccgcaaac tgaagcgggt caaaaaggac aaaaaggagg 14220

aggaagatga cggactggtg gagtttgtgc gcgagttcgc cccccggcgg cgcgtgcagt 14280

ggcgcgggcg gaaagtgaaa ccggtgctgc ggcccggcac cacggtggtc ttcacgcccg 14340

gcgagcgttc cggctccgcc tccaagcgct cctacgacga ggtgtacggg gacgaggaca 14400

tcctcgagca ggcggtcgag cgtctgggcg agtttgctta cggcaagcgc agccgccccg 14460

cgcccttgaa agaggaggcg gtgtccatcc cgctggacca cggcaacccc acgccgagcc 14520

tgaagccggt gaccctgcag caggtgctgc cgagcgcggc gccgcgccgg ggcttcaagc 14580

gcgagggcgg cgaggatctg tacccgacca tgcagctgat ggtgcccaag cgccagaagc 14640

tggaggacgt gctggagcac atgaaggtgg accccgaggt gcagcccgag gtcaaggtgc 14700

ggcccatcaa gcaggtggcc ccgggcctgg gcgtgcagac cgtggacatc aagatcccca 14760

cggagcccat ggaaacgcag accgagcccg tgaagcccag caccagcacc atggaggtgc 14820

agacggatcc ctggatgcca gcggcttcca ccaccaccac tcgccgaaga cgcaagtacg 14880

gcgcggccag cctgctgatg cccaactacg cgctgcatcc ttccatcatc cccacgccgg 14940

gctaccgcgg cacgcgcttc taccgcggct acaccagcag ccgccgccgc aagaccacca 15000

cccgccgccg tcgtcgcagc cgccgcagca gcaccgcgac ttccgccttg gtgcggagag 15060

tgtatcgcag cgggcgcgag cctctgaccc tgccgcgcgc gcgctaccac ccgagcatcg 15120

ccatttaact accgcctcct acttgcagat atggccctca catgccgcct ccgcgtcccc 15180

attacgggct accgaggaag aaagccgcgc cgtagaaggc tgacggggaa cgggctgcgt 15240

cgccatcacc accggcggcg gcgcgccatc agcaagcggt tgggggggagg cttcctgccc 15300

gcgctgatcc ccatcatcgc cgcggcgatc ggggcgatcc ccggcatagc ttccgtggcg 15360

gtgcaggcct ctcagcgcca ctgagacaca aaaaagcatg gatttgtaat aaaaaaatgg 15420

actgacgctc ctggtcctgt gatgtgtgtt tttagatgga agacatcaat ttttcgtccc 15480

tggcaccgcg acacggcacg cggccgttta tgggcacctg gagcgacatc ggcaacagcc 15540

aactgaacgg gggcgccttc aattggagca gtctctggag cgggcttaag aatttcgggt 15600

ccacgctcaa aacctatggc aacaaggcgt ggaacagcag cacagggcag gcgctgaggg 15660

aaaagctgaa agagcagaac ttccagcaga aggtggtcga tggcctggcc tcgggcatca 15720

acggggtggt ggacctggcc aaccaggccg tgcagaaaca gatcaacagc cgcctggacg 15780

cggtcccgcc cgcggggtcc gtggagatgc cccaggtgga ggaggagctg cctcccctgg 15840

acaagcgcgg cgacaagcga ccgcgtcccg acgcggagga gacgctgctg acgcacacgg 15900

acgagccgcc cccgtacgag gaggcggtga aactgggtct gcccaccacg cggcccgtgg 15960

cgcctctggc caccggggtg ctgaaaccca gcagcagcag ccagcccgcg accctggact 16020

tgcctccgcc tgcttcccgc ccctccacag tggctaagcc cctgccgccg gtggccgtcg 16080

cgtcgcgcgc cccccgaggc cgcccccagg cgaactggca gagcactctg aacagcatcg 16140

tgggtctggg agtgcagagt gtgaagcgcc gccgctgcta ttaaaagaca ctgtagcgct 16200

taacttgctt gtctgtgtgt gtatatgtat gtccgccgac cagaaggagg aagaggcgcg 16260

tcgccgagtt gcaagatggc caccccatcg atgctgcccc agtgggcgta catgcacatc 16320

gccggacagg acgcttcgga gtacctgagt ccgggtctgg tgcagttcgc ccgcgccaca 16380

gacacctact tcagtctggg gaacaagttt aggaacccca cggtggcgcc cacgcacgat 16440

gtgaccaccg accgcagcca gcggctgacg ctgcgcttcg tgcccgtgga ccgcgaggac 16500

aacacctact cgtacaaagt gcgctacacg ctggccgtgg gcgacaaccg cgtgctggac 16560

atggccagca cctactttga catccgcggc gtgctggatc ggggccccag cttcaaaccc 16620

tactccggca ccgcctacaa cagcctagct cccaagggag cgcccaacac ctcacagtgg 16680

aaggattccg acagcaaaat gcatactttt ggagttgctg ccatgcccgg tgttgttggt 16740

aaaaaaatag aagccgatgg tctgcctatt ggaatagatt catcctctgg aactgacacc 16800

ataatttatg ctgataaaac tttccaacca gagccacagg ttggaagtga cagttgggtc 16860

gacaccaatg gtgcagagga aaaatatgga ggtagagctc ttaaggacac tacaaacatg 16920

aagccctgct acggttcttt tgccaggcct accaacaaag aaggtggaca ggctaacata 16980

aaagattctg aaactgccag cactactcct aactatgata tagatttggc attctttgac 17040

agcaaaaata ttgcagctaa ctacgatcca gatattgtaa tgtacacaga aaatgttgag 17100

ttgcaaactc cagatactca tattgtgttt aagccaggaa cttcagatga aagttcagaa 17160

gccaatttgg gccagcaggc catgcccaac agacccaact acatcgggtt cagagacaac 17220

tttatcgggc tcatgtacta caacagcact ggcaatatgg gtgtactggc tggtcaggcc 17280

tcccagctaa atgctgtggt ggacttgcag gacagaaaca ccgaactgtc ctaccagctc 17340

ttgcttgact ctctgggtga cagaaccagg tatttcagta tgtggaatca ggcggtggac 17400

agctatgacc ccgatgtgcg cattattgaa aatcacggtg tggaggatga actccccaat 17460

tattgcttcc ctttgaatgg tgtaggcttt acagatactt accagggtgt taaagttaag 17520

acagatacag ccgctactgg taccaatgga acgcagtggg acaaagatga taccacagtc 17580

agcactgcca atgagatcca ctcaggcaat cctttcgcca tggagatcaa catccaggcc 17640

aacctgtggc ggaacttcct ctacgcgaac gtggcgctgt acctgcccga ctcctacaag 17700

tacacgccgg ccaacatcac gctgccgacc aacaccaaca cctacgatta catgaacggc 17760

cgcgtggtgg cgccctcgct ggtggacgcc tacatcaaca tcggggcgcg ctggtcgctg 17820

gaccccatgg acaacgtcaa ccccttcaac caccaccgca acgcgggcct gcgctaccgc 17880

tccatgctcc tgggcaacgg gcgctacgtg cccttccaca tccaggtgcc ccaaaagttt 17940

ttcgccatca agagcctcct gctcctgccc gggtcctaca cctacgagtg gaacttccgc 18000

aaggacgtca acatgatcct gcagagctcc ctcggcaacg acctgcgcac ggacggggcc 18060

tccatcgcct tcaccagcat caacctctac gccaccttct tccccatggc gcacaacacc 18120

gcctccacgc tcgaggccat gctgcgcaac gacaccaacg accagtcctt caacgactac 18180

ctctcggcgg ccaacatgct ctaccccatc ccggccaacg ccaccaacgt gcccatctcc 18240

atcccctcgc gcaactgggc cgccttccgc ggatggtcct tcacgcgcct caagacccgc 18300

gagacgccct cgctcggctc cgggttcgac ccctacttcg tctactcggg ctccatcccc 18360

tacctcgacg gcaccttcta cctcaaccac accttcaaga aggtctccat caccttcgac 18420

tcctccgtca gctggcccgg caacgaccgc ctcctgacgc ccaacgagtt cgaaatcaag 18480

cgcaccgtcg acggagaggg atacaacgtg gcccagtgca acatgaccaa ggactggttc 18540

ctggtccaga tgctggccca ctacaacatc ggctaccagg gcttctacgt gcccgagggc 18600

tacaaggacc gcatgtactc cttcttccgc aacttccagc ccatgagccg ccaggtcgtg 18660

gacgaggtca actacaagga ctaccaggcc gtcaccctgg cctaccagca caacaactcg 18720

ggcttcgtcg gctacctcgc gcccaccatg cgccagggcc agccctaccc cgccaactac 18780

ccctacccgc tcatcggcaa gagcgccgtc gccagcgtca cccagaaaaa gttcctctgc 18840

gaccgggtca tgtggcgcat ccccttctcc agcaacttca tgtccatggg cgcgctcacc 18900

gacctcggcc agaacatgct ctacgccaac tccgcccacg cgctagacat gaatttcgaa 18960

gtcgacccca tggatgagtc cacccttctc tatgttgtct tcgaagtctt cgacgtcgtc 19020

cgagtgcacc agccccaccg cggcgtcatc gaggccgtct acctgcgcac gcccttctcg 19080

gccggcaacg ccaccaccta aagccccgct cttgcttctt gcaagatgac ggcctgtggc 19140

tccggcgagc aggagctcag ggccatcctc cgcgacctgg gctgcgggcc ctgcttcctg 19200

ggcaccttcg acaagcgctt cccgggattc atggccccgc acaagctggc ctgcgccatc 19260

gtcaacacgg ccggccgcga gaccgggggc gagcactggc tggccttcgc ctggaacccg 19320

cgctcccaca cctgctacct cttcgacccc ttcgggttct cggacgagcg cctcaagcag 19380

atctaccagt tcgagtacga gggcctgctg cgccgcagcg ccctggccac cgaggaccgc 19440

tgcatcaccc tggaaaagtc cacccagacc gtgcagggtc cgcgctcggc cgcctgcggg 19500

ctcttctgct gcatgttcct gcacgccttc gtgcactggc ccgaccgccc catggacaag 19560

aaccccacca tgaacttgct gacgggggtg cccaacggca tgctccagtc gccccaggtg 19620

gaacccaccc tgcgccgcaa ccaggaggcg ctctaccgct tcctcaacgc ccactccgcc 19680

tactttcgct cccaccgcgc gcgcatcgag aaggccaccg ccttcgaccg catgaatcaa 19740

gacatgtaaa ctgtgtgtat gtgaatgctt tattcatcat aataaacagc acatgtttat 19800

gccaccttct ctgaggctct gactttattt agaaatcgaa ggggttctgc cggctctcgg 19860

cgtgccccgc gggcagggat acgttgcgga actggtactt gggcagccac ttgaactcgg 19920

ggatcagcag cttcggcacg gggaggtcgg ggaacgagtc gctccacagc ttgcgcgtga 19980

gttgcagggc gcccagcagg tcgggcgcgg agatcttgaa atcgcagttg ggacccgcgt 20040

tctgcgcgcg agagttgcgg tacacggggt tgcagcactg gaacaccatc agggccgggt 20100

gcttcacgct cgccagcacc gtcgcgtcgg tgatgccctc cacgtccaga tcctcggcgt 20160

tggccatccc gaagggggtc atcttgcagg tctgccgccc catgctgggc acgcagccgg 20220

gcttgtggtt gcaatcgcag tgcaggggga tcagcatcat ctgagcctgc tcggagctca 20280

tgcccgggta catggccttc atgaaagcct ccagctggcg gaaggcctgc tgcgccttgc 20340

cgccctcggt gaagaagacc ccacaggact tgctagagaa ctggttggtg gcgcagcccg 20400

cgtcgtgcac gcagcagcgc gcgtcgttgt tggccagctg caccacgctg cgcccccagc 20460

ggttctgggt gatcttggcc cggtcggggt tctccttcag cgcgcgctgc ccgttctcgc 20520

tcgccacatc catctcgatc gtgtgctcct tctggatcat cacggtcccg tgcaggcacc 20580

gcagcttgcc ctcggcctcg gtgcacccgt gcagccacag cgcgcagccg gtgcactccc 20640

agttcttgtg ggcgatctgg gagtgcgagt gcacgaagcc ctgcaggaag cggcccatca 20700

tcgtggtcag ggtcttgttg ctggtgaagg tcagcgggat gccgcggtgc tcctcgttca 20760

catacaggtg gcagatgcgg cggtacacct cgccctgctc gggcatcagc tggaaggcgg 20820

acttcaggtc gctctccacg cggtaccgct ccatcagcag cgtcatcact tccatgccct 20880

tctcccaggc cgaaacgatc ggcaggctca gggggttctt caccgtcatc ttagtcgccg 20940

ccgccgaagt cagggggtcg ttctcgtcca gggtctcaaa cactcgcttg ccgtccttct 21000

cggtgatgcg cacggggggga aagctgaagc ccacggccgc cagctcctcc tcggcctgcc 21060

tttcgtcctc gctgtcctgg ctgatgtctt gcaaaggcac atgcttggtc ttgcggggtt 21120

tctttttggg cggcagaggc ggcggcggag acgtgctggg cgagcgcgag ttctcgctca 21180

ccacgactat ttcttcttct tggccgtcgt ccgagaccac gcggcggtag gcatgcctct 21240

tctggggcag aggcggaggc gacgggctct cgcggttcgg cgggcggctg gcagagcccc 21300

ttccgcgttc gggggtgcgc tcctggcggc gctgctctga ctgacttcct ccgcggccgg 21360

ccattgtgtt ctcctaggga gcaacaagca tggagactca gccatcgtcg ccaacatcgc 21420

catctgcccc cgccgccgac gagaaccagc agcagcagaa tgaaagctta accgccccgc 21480

cgcccagccc cacctccgac gccgccgcgg ccccagacat gcaagagatg gaggaatcca 21540

tcgagattga cctgggctac gtgacgcccg cggagcacga ggaggagctg gcagcgcgct 21600

tttcagcccc ggaagagaac caccaagagc agccagagca ggaagcagag agcgagcagc 21660

agcaggctgg gctcgagcat ggcgactacc tgagcggggc agaggacgtg ctcatcaagc 21720

atctggcccg ccaaagcatc atcgtcaagg acgcgctgct cgaccgcgcc gaggtgcccc 21780

tcagcgtggc ggagctcagc cgcgcctacg agcgcaacct cttctcgccg cgcgtgcccc 21840

ccaagcgcca gcccaacggc acctgcgagc ccaacccgcg cctcaacttc tacccggtct 21900

tcgcggtgcc cgaggccctg gccacctacc acctcttttt caagaaccaa aggatccccg 21960

tctcctgccg cgccaaccgc acccgcgccg acgccctgct caacctgggt cccggcgccc 22020

gcctacctga tatcacctcc ttggaagagg ttcccaagat cttcgagggt ctgggcagcg 22080

acgagactcg ggccgcgaac gctctgcaag gaagcggaga ggagcatgag caccacagcg 22140

ccctggtgga gttggaaggc gacaacgcgc gcctggcggt gctcaagcgc acggtcgagc 22200

tgacccactt cgcctacccg gcgctcaacc tgcccccccaa ggtcatgagc gccgtcatgg 22260

accaggtgct catcaagcgc gcctcgcccc tctcagagga ggagatgcag gaccccgaga 22320

gctcggacga gggcaagccc gtggtcagcg acgagcagct ggcgcgctgg ctgggagcga 22380

gcagcacccc ccagagcctg gaagagcggc gcaagctcat gatggccgtg gtcctggtga 22440

ccgtggagct ggagtgtctg cgccgcttct tcgccgacgc ggagaccctg cgcaaggtcg 22500

aggagaacct gcactacctc ttcaggcacg ggttcgtgcg ccaggcctgc aagatctcca 22560

acgtggagct gaccaacctg gtctcctaca tgggcatcct gcacgagaac cgcctggggc 22620

agaacgtgct gcacaccacc ctgcgcgggg aggcccgccg cgactacatc cgcgactgcg 22680

tctacctgta cctctgccac acctggcaga cgggcatggg cgtgtggcag cagtgcctgg 22740

aggagcagaa cctgaaagag ctctgcaagc tcctgcagaa gaacctcaag gccctgtgga 22800

ccgggttcga cgagcgcacc accgcctcgg acctggccga cctcatcttc cccgagcgcc 22860

tgcggctgac gctgcgcaac gggctgcccg actttatgag ccaaagcatg ttgcaaaact 22920

ttcgctcttt catcctcgaa cgctccggga tcctgcccgc cacctgctcc gcactgccct 22980

cggacttcgt gccgctgacc ttccgcgagt gccccccgcc gctctggagc cactgctact 23040

tgctgcgcct ggccaactac ctggcctacc actcggacgt gatcgaggac gtcagcagcg 23100

agggtctgct cgagtgccac tgccgctgca acctctgcac gccgcaccgc tccttggcct 23160

gcaaccccca gctgctgagc gagacccaga tcatcggcac cttcgagttg caaggccccg 23220

gcgagggcaa ggggggtctc aaactcaccc cggggctgtg gacctcggcc tacttgcgca 23280

agttcgtgcc cgaggactac catcccttcg agatcaggtt ctacgaggac caatcccagc 23340

cgcccaaggc cgagctgtcg gcctgcgtca tcacccaggg ggccatcctg gcccaattgc 23400

aagccatcca gaaatcccgc caagaatttc tgctgaaaaa gggccacggg gtctacttgg 23460

acccccagac cggagaggag ctcaacccca gcttccccca ggatgccccg aggaagcagc 23520

aagaagctga aagtggagct gccgctgccg ccggaggatt tggaggaaga ctgggagagc 23580

agtcaggcag aggagatgga agactgggac agcactcagg cagaggagga cagcctgcaa 23640

gacagtctgg aggaggaaga cgaggtggag gaggaggcag aggaagaagc agccgccgcc 23700

agaccgtcgt cctcggcgga ggagaaagca agcagcacgg ataccatctc cgctccgggt 23760

cggggtcgcg gcggccgggc ccacagtaga tgggacgaga ccgggcgctt cccgaacccc 23820

accacccaga ccggtaagaa ggagcggcag ggatacaagt cctggcgggg gcacaaaaac 23880

gccatcgtct cctgcttgca agcctgcggg ggcaacatct ccttcacccg gcgctacctg 23940

ctcttccacc gcggggtgaa cttccccccgc aacatcttgc attactaccg tcacctccac 24000

agcccctact actgtttcca agaagaggca gaaacccagc agcagcagca gaaaaccagc 24060

ggcagcagca gcagctagaa aatccacagc ggcggcaggt ggactgagga tcgcggcgaa 24120

cgagccggcg cagacccggg agctgaggaa ccggatcttt cccaccctct atgccatctt 24180

ccagcagagt cgggggcagg agcaggaact gaaagtcaag aaccgttctc tgcgctcgct 24240

cacccgcagt tgtctgtatc acaagagcga agaccaactt cagcgcactc tcgaggacgc 24300

cgaggctctc ttcaacaagt actgcgcgct cactcttaaa gagtagcccg cgcccgccca 24360

cacacggaaa aaggcgggaa ttacgtcacc acctgcgccc ttcgcccgac catcatcatg 24420

agcaaagaga ttcccacgcc ttacatgtgg agctaccagc cccagatggg cctggccgcc 24480

ggcgccgccc aggactactc cacccgcatg aactggctca gtgccgggcc cgcgatgatc 24540

tcacgggtga atgacatccg cgcccaccga aaccagatac tcctagaaca gtcagcgatc 24600

accgccacgc cccgccatca ccttaatccg cgtaattggc ccgccgccct ggtgtaccag 24660

gaaattcccc agcccacgac cgtactactt ccgcgagacg cccaggccga agtccagctg 24720

actaactcag gtgtccagct ggccggcggc gccgccctgt gtcgtcaccg ccccgctcag 24780

ggtataaagc ggctggtgat ccgaggcaga ggcacacagc tcaacgacga ggtggtgagc 24840

tcttcgctgg gtctgcgacc tgacggagtc ttccaactcg ccggatcggg gagatcttcc 24900

ttcacgcctc gtcaggccgt cctgactttg gagagttcgt cctcgcagcc ccgctcgggc 24960

ggcatcggca ctctccagtt cgtggaggag ttcactccct cggtctactt caaccccttc 25020

tccggctccc ccggccacta cccggacgag ttcatcccga acttcgacgc catcagcgag 25080

tcggtggacg gctacgattg aatgtcccat ggtggcgcgg ctgacctagc tcggcttcga 25140

cacctggacc actgccgccg cttccgctgc ttcgctcggg atctcgccga gtttgcctac 25200

tttgagctgc ccgaggagca ccctcagggc ccggcccacg gagtgcggat cgtcgtcgaa 25260

gggggcctcg actcccacct gcttcggatt ttcagccagc gtccgatcct ggtcgagcgc 25320

gagcaaggac agacccttct gaccctgtac tgcatctgca accaccccgg cctgcatgaa 25380

agtctttgtt gtctgctgtg tactgagtat aataaaagct gagatcagcg actactccgg 25440

actcgattgt ggtgttcctg ctatcaaccg gtccctgttc ttcaccggga acgagaccga 25500

gctccagctc cagtgtaagc cccacaagaa gtatctcacc tggctgttcc agggctctcc 25560

gatcgccgtt gtcaaccact gcgacaacga cggagtcctg ctgagcggcc ctgccaacct 25620

tactttttcc acccgcagaa gcaagctcca gctcttccaa cccttcctcc ccgggaccta 25680

tcagtgcgtc tcgggaccct gccatcacac cttccacctg atcccgaata ccacagcgcc 25740

gctccccgct actaacaacc aaactaccca ccaacgccac cgtcgcgacc tttctgaatc 25800

taatactacc acccacaccg gaggtgagct ccgaggtcga ccaacctctg ggatttacta 25860

cggggttaac cccttaatta aggggattcc atatggtacg tacatcgcct ctcctacgag 25920

ctcctgcagc agcgccagaa gttcacctgc ctggtcggag tcaaccccat cgtcatcacc 25980

cagcagtcgg gcgataccaa ggggtgcatc cactgctcct gcgactcccc cgactgcgtc 26040

cacactctga tcaagaccct ctgcggcctc cgcgacctcc tccccatgaa ctaatcaccc 26100

ccttatccag tgaaataaag atcatattga tgatgatttt acagaaataa agatacaatc 26160

atattgatga tttgagttta ataaaaaata aagaatcact tacttgaaat ctgataccag 26220

gtctctgtcc atgttttctg ccaacaccac ttcactcccc tcttcccagc tctggtactg 26280

caggccccgg cgggctgcaa acttcctcca cacgctgaag gggatgtcaa attcctcctg 26340

tccctcaatc ttcattttat cttctatcag atgtccaaaa agcgcgtccg ggtggatgat 26400

gacttcgacc ccgtctaccc ctacgatgca gacaacgcac cgaccgtgcc cttcatcaac 26460

ccccccttcg tctcttcaga tggattccaa gagaagcccc tgggggtgct gtccctgcga 26520

ctggccgacc ccgtcaccac caagaacggg gaaatcaccc tcaagctggg agagggggtg 26580

gacctcgact cctcgggaaa actcatctcc aacacggcca ccaaggccgc cgcccctctc 26640

agtttttcca acaacaccat ttcccttaac atggatcacc ccttttacac taaagatgga 26700

aaattatcct tacaagtttc tccaccatta aatatactga gaacaagcat tctaaacaca 26760

ctagctttag gttttggatc aggtttagga ctccgtggct ctgccttggc agtacagtta 26820

gtctctccac ttacatttga tactgatgga aacataaagc ttaccttaga cagaggtttg 26880

catgttacaa caggagatgc aattgaaagc aacataagct gggctaaagg tttaaaattt 26940

gaagatggag ccatagcaac caacattgga aatgggttag agtttggaag cagtagtaca 27000

gaaacaggtg ttgatgatgc ttacccaatc caagttaaac ttggatctgg ccttagcttt 27060

gacagtacag gagccataat ggctggtaac aaagaagacg ataaactcac tttgtggaca 27120

acacctgatc catcgccaaa ctgtcaaata ctcgcagaaa atgatgcaaa actaacactt 27180

tgcttgacta aatgtggtag tcaaatactg gccactgtgt cagtcttagt tgtaggaagt 27240

ggaaacctaa accccattac tggcaccgta agcagtgctc aggtgtttct acgttttgat 27300

gcaaacggtg ttcttttaac agaacattct acactaaaaa aatactgggg gtataggcag 27360

ggagatagca tagatggcac tccatatacc aatgctgtag gattcatgcc caatttaaaa 27420

gcttatccaa agtcacaaag ttctactact aaaaataata tagtagggca agtatacatg 27480

aatggagatg tttcaaaacc tatgcttctc actataaccc tcaatggtac tgatgacagc 27540

aacagtacat attcaatgtc attttcatac acctggacta atggaagcta tgttggagca 27600

acatttgggg ctaactctta taccttctca tacatcgccc aagaatgaac actgtatccc 27660

accctgcatg ccaacccttc ccaccccact ctgtggaaaa aactctgaaa cacaaaataa 27720

aataaagttc aagtgtttta ttgattcaac agttttacag gattcgagca gttatttttc 27780

ctccaccctc ccaggacatg gaatacacca ccctctcccc ccgcacagcc ttgaacatct 27840

gaacgccatt ggtgatggac atgcttttgg tctccacgtt ccacacagtt tcagagcgag 27900

ccagtctcgg gtcggtcagg gagatgaaac cctccgggca caattgggag aagtactcgc 27960

ctattatctg gaagaagcag aagagcggcg gtgggaatca tagtccgcga acgggatcgg 28020

ccggtggtgt cgcatcaggc cccgcagcag tcgctgccgc cgccgctccg tcaagctgct 28080

gctcaggggg tccgggtcca gggactccct cagcatgatg cccacggccc tcagcatcag 28140

tcgtctggtg cggcgggcgc agcagcgcat gcggatctcg ctcaggtcgc tgcagtacgt 28200

gcaacacaga accaccaggt tgttcaacag tccatagttc aacacgctcc agccgaaact 28260

catcgcggga aggatgctac ccacgtggcc gtcgtaccag atcctcaggt aaatcaagtg 28320

gtgccccctc cagaacacgc tgcccacgta catgatctcc ttgggcatgt ggcggttcac 28380

cacctcccgg taccacatca ccctctggtt gaacatgcag ccccggatga tcctgcggaa 28440

ccacagggcc agcaccgccc cgcccgccat gcagcgaaga gaccccgggt cccggcaatg 28500

gcaatggagg acccaccgct cgtacccgtg gatcatctgg gagctgaaca agtctatgtt 28560

ggcacagcac aggcatatgc tcatgcatct cttcagcact ctcaactcct cgggggtcaa 28620

aaccatatcc cagggcacgg ggaactcttg caggacagcg aaccccgcag aacagggcaa 28680

tcctcgcaca gaacttacat tgtgcatgga cagggtatcg caatcaggca gcaccgggtg 28740

atcctccacc agagaagcgc gggtctcggt ctcctcacag cgtggtaagg gggccggccg 28800

atacgggtga tggcgggacg cggctgatcg tgttcgcgac cgtgtcatga tgcagttgct 28860

ttcggacata tttcctgaag tcttggcgcg ccaaagtcta gacagcgtcc atagcttacc 28920

gagcagcagc agcagcacac aacaggcgca agagtcagag aaaggctgag ctctaacctg 28980

tccacccgct ctctgctcaa tatatagccc agatctacac tgacgtaaag gccaaagtct 29040

aaaaataccc gccaaatagt cacacacgcc cagcacacgc ccagaaaccg gtgacacact 29100

caaaaaaata cgcgcacttc ctcaaacgcc caaactgccg tcatttccgg gttcccacgc 29160

tacgtcatca aaacacgact ttcaaattcc gtcgaccgtt aaaaacgtca cccgccccgc 29220

ccctaacggt cgcccgtctc tcagccaatc agcgccccgc atccccaaat tcaaacacct 29280

catttgcata ttaacgcgca ccaaaagttt gaggtatatt attgatgatg attt 29334

<210> 15

<211> 34653

<212> DNA

<213> Artificial Sequence

<400> 15

cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg 60

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca 120

gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt 180

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg 240

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct 300

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat 360

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc 420

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg 480

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg 540

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga 600

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta 660

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc 720

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc 780

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg 840

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc 900

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca 960

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct 1020

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat 1080

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg 1140

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat 1200

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact 1260

tcatttttaa tttaaaagga tctaggtgaa gatcctttttt gataatctca tgaccaaaat 1320

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc 1380

ttcttgagat ccttttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct 1440

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg 1500

cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca 1560

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc 1620

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga 1680

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac 1740

gacctacacc gaactgagat acctacagcg tgagctttga gatagcgcca cgcttcccga 1800

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag 1860

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg 1920

acttgagcgt cgattttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag 1980

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc 2040

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc 2100

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc 2160

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag 2220

gtttcccgac tggatttaaa tcatcatcaa taatatacct caaacttttg gtgcgcgtta 2280

atatgcaaat gaggtgtttg aatttgggga tgcggggcgc tgattggctg agagacgggc 2340

gaccgttagg ggcggggcgg gtgacgtttt gatgacgtgg ccgtgaggcg gagccggttt 2400

gcaagttctc gtgggaaaag tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca 2460

attttcccgc gctctctgac aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg 2520

gccattttcg cgcgaaaact gaatgaggaa gtgaaaatct gagtaattcc gcgtttatgg 2580

cagggaggag tatttgccga gggccgagta gactttgacc gattacgtgg gggtttcgat 2640

taccgtattt ttcacctaaa tttccgcgta cggtgtcaaa gtccggtgtt tttacgtagg 2700

cgtcagctga tcgccagggt atttaaacct gcgctctcta gtcaagaggc cactcttgag 2760

tgccagcgag tagagttttc tcctccgcgc cgcgagtcag atctacactt tgaaaggcga 2820

tcgccgatat catttccccg aaaagtgcca cctgaccgta actataacgg tcctaaggta 2880

gcgaaagctc agatctcccg atcccctatg gtgcactctc agtacaatct gctctgatgc 2940

cgcatagtta agccagtatc tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc 3000

gagcaaaatt taagctacaa caaggcaagg cttgaccgac aattgcatga agaatctgct 3060

tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc agatatacgc gttgacattg 3120

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat 3180

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc 3240

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca 3300

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta 3360

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta 3420

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat 3480

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga 3540

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca 3600

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg 3660

taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcac 3720

tagaagcttt attgcggtag tttatcacag ttaaattgct aacgcagtca gtgcttctga 3780

cacaacagtc tcgaacttaa gctgcagaag ttggtcgtga ggcactgggc aggtaagtat 3840

caaggttaca agacaggttt aaggagacca atagaaactg ggcttgtcga gacagagaag 3900

actcttgcgt ttctgatagg cacctattgg tcttactgac atccactttg cctttctctc 3960

cacaggtgtc cactcccagt tcaattacag ctcttaaggc tagagtactc tagcccggga 4020

tccaccggtc gccaccatgt ttcaggatcc ccaggagcgg ggccgcaagc tgccacagct 4080

gtgcacagag ctccagacaa ccattcacga tattattctc gagtgcgtct actgtaagca 4140

gcagctcctg cgccgggagg tctacgactt cgctagacgc gacctgtgta tcgtctaccg 4200

cgatggaaat ccatacgccg tcggcgataa gtgcctcaag ttttactcta agatttctga 4260

gtaccggcac tactgttact cactgtacgg aaccaccctc gagcagcagt acaataagcc 4320

tctgtgtgat ctgctcatta gatgcattaa tggccagaag cctctctgtc cagaggagaa 4380

gcagcggcac ctcgataaga agcagcggtt tcacaatact aggggaaggt ggaccggaag 4440

gtgtatgtca tgttgtcggt catcaagaac tagacgcgag acacagctca gaaagaggcg 4500

cgggtcaggc gcaccagtca agcagactct gaactttgat ctcctcaagc tcgctggcga 4560

cgtcgagtct aatcctggcc cccacggcga caccccaacc ctccacgagt acatgctgga 4620

tctccagccc gagacaaccg acctctacgg gtacgggcag ctcaatgatt catcagagga 4680

ggaggatgag attgatggcc ccgccggaca ggctgagccc gatagggccc actacaatat 4740

cgtgacattt tgttgcaagg gcgattcaac actccgcctg tgcgtgcagt caacccacgt 4800

ggatattcgg actctcgagg atctgctcat gggaacactg ggaattgtgt gccctatttg 4860

ttcccagaag cctagaaaga ggcgcgggtc cggcgcaaca aattttagcc tgctcaagca 4920

ggctggcgac gtcgaggaga atcctgggcc cgctaggttt gaggatccaa ctagacgcgg 4980

gtacaagctc cccgatctgt gtacagagct gaatacatca ctccaggata ttgagattac 5040

ttgcgtgtac tgtaagaccg tcctcgagct gactgaggtc tttgagttcg ctagaaagga 5100

tctcttcgtg gtctaccggg attctatccc acacgccgcc ggacacaagt gcattgactt 5160

ttactctcgc attagggagc tcaggcacta ctccgatagc gtctacgggg atacactgga 5220

gaagctgact aatactggac tgtacaatct gctcattaga tgcctgcgcg gacagaagcc 5280

tctcaatccc gctgagaagc tgcggcacct gaatgagaag agacggtttc acaataccgc 5340

cggacactac cggggccagt gtcactcttg ttgtaatagg gctaggcagg agcggctcca 5400

gagacgccgc gagactcagg tccgcaagag gcgcgggtcc ggcgcacccg tgaagcagac 5460

cctgaacttt gatctcctga agctcgctgg ggacgtggag tctaaccctg ggccacacgg 5520

accaaaggct accctccagg atatcgtcct gcacctcgag ccacagaatg agattcccgt 5580

cgacctgctc ggccacggac agctgtccga tagcgaggag gagaacgatg agattgatgg 5640

ggtgaatcac cagcacctgc ccgctagacg cgccgagcca cagcggcaca ccatgctgtg 5700

tatgtgttgc aagggggagg cacgcatcga gctggtggtg gagtcttccg ccgatgacct 5760

cagggctttt cagcagctct ttctgaatac cctgtccttc gtgtgccctt ggtgcgcttc 5820

ccagcagtga agcggccgcc actgtgctgg atgatccgag ctcggtacct ctagagtcga 5880

cccgggcggc caaaccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt 5940

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc 6000

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt 6060

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat 6120

gcggtgggct ctatggcttc tgaggcggaa agaaccagca gatctgcaga tctgaattca 6180

tctatgtcgg gtgcggagaa agaggtaatg aaatggcatt atgggtatta tgggtctgca 6240

ttaatgaatc ggccagatat cgacatatgc tggccaccgt acatgtggct tcccatgctc 6300

gcaagccctg gcccgagttc gagcacaatg tcatgaccag gtgcaatatg catctggggt 6360

cccggcgatc gcccgaggca tgttcatgcc ctaccagtgc aacatgcaat ttgtgaaggt 6420

gctgctggag cccgatgcca tgtccagagt gagcctgacg ggggtgtttg acatgaatgt 6480

ggagctgtgg aaaattctga gatatgatga atccaagacc aggtgccggg cctgcgaatg 6540

cggaggcaag cacgccaggc ttcagcccgt gtgtgtggag gtgacggagg acctgcgacc 6600

cgatcatttg gtgttgtcct gcaacgggac ggagttcggc tccagcgggg aagaatctga 6660

ctagagtgag tagtgtttgg gggtgggtgg gagcctgcat gatgggcaga atgactaaaa 6720

tctgtgtttt tctgtgtgtt gcagcagcat gagcggaagc gcctcctttg agggaggggt 6780

attcagccct tatctgacgg ggcgtctccc ctcctgggcg ggagtgcgtc agaatgtgat 6840

gggatccacg gtggacggcc ggcccgtgca gcccgcgaac tcttcaaccc tgacctacgc 6900

gaccctgagc tcctcgtccg tggacgcagc tgccgccgca gctgctgctt ccgccgccag 6960

cgccgtgcgc ggaatggccc tgggcgccgg ctactacagc tctctggtgg ccaactcgag 7020

ttccaccaat aatcccgcca gcctgaacga ggagaagctg ttgctgctga tggcccagct 7080

cgaggccctg acccagcgcc tgggcgagct gacccagcag gtggctcagc tgcaggcgga 7140

gacgcgggcc gcggttgcca cggtgaaaac caaataaaaa atgaatcaat aaataaacgg 7200

agacggttgt tgattttaac acagagtctt gaatctttat ttgattttttc gcgcgcggta 7260

ggccctggac caccggtctc gatcattgag cacccggtgg atcttttcca ggacccggta 7320

gaggtgggct tggatgttga ggtacatggg catgagcccg tcccgggggt ggaggtagct 7380

ccattgcagg gcctcgtgct cgggggtggt gttgtaaatc acccagtcat agcaggggcg 7440

cagggcgtgg tgctgcacga tgtctttgag gaggagactg atggccacgg gcagcccctt 7500

ggtgtaggtg ttgacgaacc tattgagctg ggagggatgc atgcgggggg agatgagatg 7560

catcttggcc tggatcttga gattggcgat gttcccgccc agatcccgcc gggggttcat 7620

gttgtgcagg accaccagca cggtgtatcc ggtgcacttg gggaatttgt catgcaactt 7680

ggaagggaag gcgtgaaaga atttggagac gcccttgtga ccgcccaggt tttccatgca 7740

ctcatccatg atgatggcga tgggcccgtg ggcggcggcc tgggcaaaga cgtttcgggg 7800

gtcggacaca tcgtagttgt ggtcctgggt gagctcgtca taggccattt taatgaattt 7860

ggggcggagg gtacccgact gggggacaaa ggtgccctcg atcccggggg cgtagttccc 7920

ctcgcagatc tgcatctccc aggccttgag ctcggagggg gggatcatgt ccacctgcgg 7980

ggcgatgaaa aaaacggttt ccggggcggg ggagatgagc tgcgccgaaa gcaggttccg 8040

gagcagctgg gacttgccgc agccggtggg gccgtagatg accccgatga ccggctgcag 8100

gtggtagttg agggagagac agctgccgtc ctcgcggagg aggggggcca cctcgttcat 8160

catctcgcgc acatgcatgt tctcgcgcac gagttccgcc aggaggcgct cgccccccag 8220

cgagaggagc tcttgcagcg aggcgaagtt tttcagcggc ttgagcccgt cggccatggg 8280

cattttggag agggtctgtt gcaagagttc cagacggtcc cagagctcgg tgatgtgctc 8340

tagggcatct cgatccagca gacctcctcg tttcgcgggt tggggcgact gcgggagtag 8400

ggcaccaggc gatgggcgtc cagcgaggcc agggtccggt ccttccaggg tcgcagggtc 8460

cgcgtcagcg tggtctccgt cacggtgaag gggtgcgcgc cgggctgggc gcttgcgagg 8520

gtgcgcttca ggctcatccg gctggtcgag aaccgctccc ggtcggcgcc ctgcgcgtcg 8580

gccaggtagc aattgagcat gagttcgtag ttgagcgcct cggccgcgtg gcccttggcg 8640

cggagcttac ctttggaagt gtgtccgcag acgggacaga ggagggactt gagggcgtag 8700

agcttggggg cgaggaagac ggactcgggg gcgtaggcgt ccgcgccgca gctggcgcag 8760

acggtctcgc actccacgag ccaggtgagg tcggggcggt cggggtcaaa aacgaggttt 8820

cctccgtgct ttttgatgcg tttcttacct ctggtctcca tgagctcgtg tccccgctgg 8880

gtgacaaaga ggctgtccgt gtccccgtag accgacttta tgggccggtc ctcgagcggg 8940

gtgccgcggt cctcgtcgta gaggaacccc gcccactccg agacgaaggc ccgggtccag 9000

gccagcacga aggaggccac gtgggagggg tagcggtcgt tgtccaccag cgggtccacc 9060

ttctccaggg tatgcaagca catgtccccc tcgtccacat ccaggaaggt gattggcttg 9120

taagtgtagg ccacgtgacc gggggtcccg gccgggggggg tataaaaggg ggcgggcccc 9180

tgctcgtcct cactgtcttc cggatcgctg tccaggagcg ccagctgttg gggtaggtat 9240

tccctctcga aggcgggcat gacctcggca ctcaggttgt cagtttctag aaacgaggag 9300

gatttgatat tgacggtgcc gttggagacg cctttcatga gcccctcgtc catctggtca 9360

gaaaagacga tctttttgtt gtcgagcttg gtggcgaagg agccgtagag ggcgttggag 9420

agcagcttgg cgatggagcg catggtctgg ttcttttcct tgtcggcgcg ctccttggcg 9480

gcgatgttga gctgcacgta ctcgcgcgcc acgcacttcc attcggggaa gacggtggtg 9540

agctcgtcgg gcacgattct gacccgccag ccgcggttgt gcagggtgat gaggtccacg 9600

ctggtggcca cctcgccgcg caggggctcg ttggtccagc agaggcgccc gcccttgcgc 9660

gagcagaagg ggggcagcgg gtccagcatg agctcgtcgg gggggtcggc gtccacggtg 9720

aagatgccgg gcaggagctc ggggtcgaag tagctgatgc aggtgcccag atcgtccaga 9780

cttgcttgcc agtcgcgcac ggccagcgcg cgctcgtagg ggctgagggg cgtgccccag 9840

ggcatggggt gcgtgagcgc ggaggcgtac atgccgcaga tgtcgtagac gtagaggggc 9900

tcctggagga cgccgatgta ggtggggtag cagcgccccc cgcggatgct ggcgcgcacg 9960

tagtcgtaca gctcgtgcga gggcgcgagg agccccgtgc cgagattgga gcgctgcggc 10020

ttttcggcgc ggtagacgat ctggcggaag atggcgtggg agttggagga gatggtgggc 10080

ctctggaaga tgttgaagtg ggcatggggc agtccgaccg agtccctgat gaagtgggcg 10140

taggagtcct gcagcttggc gacgagctcg gcggtgacga ggacgtccag ggcgcagtag 10200

tcgagggtct cttggatgat gtcgtacttg agctggccct tctgcttcca cagctcgcgg 10260

ttgagaagga actcttcgcg gtccttccag tactcttcga gggggaaccc gtcctgatcg 10320

gcacggtaag agcccaccat gtagaactgg ttgacggcct tgtaggcgca gcagcccttc 10380

tccacgggga gggcgtaagc ttgcgcggcc ttgcgcaggg aggtgtgggt gagggcgaag 10440

gtgtcgcgca ccatgacttt gaggaactgg tgcttgaagt cgaggtcgtc gcagccgccc 10500

tgctcccaga gctggaagtc cgtgcgcttc ttgtaggcgg ggttgggcaa agcgaaagta 10560

acatcgttga agaggatctt gcccgcgcgg ggcatgaagt tgcgagtgat gcggaaaggc 10620

tggggcacct cggcccggtt gttgatgacc tgggcggcga ggacgatctc gtcgaagccg 10680

ttgatgttgt gcccgacgat gtagagttcc acgaatcgcg ggcggccctt gacgtggggc 10740

agcttcttga gctcgtcgta ggtgagctcg gcggggtcgc tgagcccgtg ctgctcgagg 10800

gcccagtcgg cgacgtgggg gttggcgctg aggaaggaag tccagagatc cacggccagg 10860

gcggtctgca agcggtcccg gtactgacgg aactgctggc ccacggccat tttttcgggg 10920

gtgacgcagt agaaggtgcg ggggtcgccg tgccagcggt cccacttgag ctggagggcg 10980

aggtcgtggg cgagctcgac gagcggcggg tccccggaga gtttcatgac cagcatgaag 11040

gggacgagct gcttgccgaa ggaccccatc caggtgtagg tttccacatc gtaggtgagg 11100

aagagccttt cggtgcgagg atgcgagccg atggggaaga actggatctc ctgccaccag 11160

ttggaggaat ggctgttgat gtgatggaag tagaaatgcc gacggcgcgc cgagcactcg 11220

tgcttgtgtt tatacaagcg tccgcagtgc tcgcaacgct gcacgggatg cacgtgctgc 11280

acgagctgta cctgggttcc tttgacgagg aatttcagtg ggcagtggag cgctggcggc 11340

tgcatctggt gctgtactac gtcctggcca tcggcgtggc catcgtctgc ctcgatggtg 11400

gtcatgctga cgagcccgcg cgggaggcag gtccagacct cggctcggac gggtcggaga 11460

gcgaggacga gggcgcgcag gccggagctg tccagggtcc tgagacgctg cggagtcagg 11520

tcagtgggca gcggcggcgc gcggttgact tgcaggagct tttccagggc gcgcgggagg 11580

tccagatggt acttgatctc cacggcgccg ttggtggcga cgtccacggc ttgcagggtc 11640

ccgtgcccct ggggcgccac caccgtgccc cgtttcttct tgggcggcgg cggctccatg 11700

cttagaagcg gcggcgagga cgcgcgccgg gcggcagggg cggctcgggg cccggaggca 11760

ggggcggcag gggcacgtcg gcgccgcgcg cgggcaggtt ctggtactgc gcccggagaa 11820

gactggcgtg agcgacgacg cgacggttga cgtcctggat ctgacgcctc tgggtgaagg 11880

ccacgggacc cgtgagtttg aacctgaaag agagttcgac agaatcaatc tcggtatcgt 11940

tgacggcggc ctgccgcagg atctcttgca cgtcgcccga gttgtcctgg taggcgatct 12000

cggtcatgaa ctgctcgatc tcctcctcct gaaggtctcc gcggccggcg cgctcgacgg 12060

tggccgcgag gtcgttggag atgcggccca tgagctgcga gaaggcgttc atgccggcct 12120

cgttccagac gcggctgtag accacggctc cgtcggggtc gcgcgcgcgc atgaccacct 12180

gggcgaggtt gagctcgacg tggcgcgtga agaccgcgta gttgcagagg cgctggtaga 12240

ggtagttgag cgtggtggcg atgtgctcgg tgacgaagaa gtacatgatc cagcggcgga 12300

gcggcatctc gctgacgtcg cccagggctt ccaagcgctc catggcctcg tagaagtcca 12360

cggcgaagtt gaaaaactgg gagttgcgcg ccgagacggt caactcctcc tccagaagac 12420

ggatgagctc ggcgatggtg gcgcgcacct cgcgctcgaa ggccccgggg ggctcctctt 12480

ccatttcctc ctcttcctcc tccactaaca tctcttctac ttcctcctca ggaggcggcg 12540

gcgggggagg ggccctgcgt cgccggcggc gcacgggcag acggtcgatg aagcgctcga 12600

tggtctcccc gcgccggcga cgcatggtct cggtgacggc gcgcccgtcc tcgcggggcc 12660

gcagcgtgaa gacgccgccg cgcatctcca ggtggccgcc gggggggtct ccgttgggca 12720

gggagagggc gctgacgatg catcttatca attgacccgt agggactccg cgcaaggacc 12780

tgagcgtctc gagatccacg ggatccgaaa accgctgaac gaaggcttcg agccagtcgc 12840

agtcgcaagg taggctgagc ccggtttctt gttcttcggg tatttggtcg ggaggcgggc 12900

gggcgatgct gctggtgatg aagttgaagt aggcggtcct gagacggcgg atggtggcga 12960

ggagcaccag gtccttgggc ccggcttgct ggatgcgcag acggtcggcc atgccccagg 13020

cgtggtcctg acacctggcg aggtccttgt agtagtcctg catgagccgc tccacgggca 13080

cctcctcctc gcccgcgcgg ccgtgcatgc gcgtgagccc gaacccgcgc tgcggctgga 13140

cgagcgccag gtcggcgacg acgcgctcgg cgaggatggc ctgctggatc tgggtgaggg 13200

tggtctggaa gtcgtcgaag tcgacgaagc ggtggtaggc tccggtgttg atggtgtagg 13260

agcagttggc catgacggac cagttgacgg tctggtggcc ggggcgcacg agctcgtggt 13320

acttgaggcg cgagtaggcg cgcgtgtcga agatgtagtc gttgcaggtg cgcacgaggt 13380

actggtatcc gacgaggaag tgcggcggcg gctggcggta gagcggccat cgctcggtgg 13440

cgggggcgcc gggcgcgagg tcctcgagca tgaggcggtg gtagccgtag atgtacctgg 13500

acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg gaactcgcgg acgcggttcc 13560

agatgttgcg cagcggcagg aagtagttca tggtggccgc ggtctggccc gtgaggcgcg 13620

cgcagtcgtg gatgctctag acatacgggc aaaaacgaaa gcggtcagcg gctcgactcc 13680

gtggcctgga ggctaagcga acgggttggg ctgcgcgtgt accccggttc gaatctcgaa 13740

tcaggctgga gccgcagcta acgtggtact ggcactcccg tctcgaccca agcctgctaa 13800

cgaaacctcc aggatacgga ggcgggtcgt tttttggcct tggtcgctgg tcatgaaaaa 13860

ctagtaagcg cggaaagcgg ccgcccgcga tggctcgctg ccgtagtctg gagaaagaat 13920

cgccagggtt gcgttgcggt gtgccccggt tcgagcctca gcgctcggcg ccggccggat 13980

tccgcggcta acgtgggcgt ggctgccccg tcgtttccaa gaccccttag ccagccgact 14040

tctccagtta cggagcgagc ccctcttttt ttcttgtgtt tttgccagat gcatcccgta 14100

ctgcggcaga tgcgccccca ccctccacca caaccgcccc taccgcagca gcagcaacag 14160

ccggcgcttc tgcccccgcc ccagcagcag cagccagcca ctaccgcggc ggccgccgtg 14220

agcggagccg gcgttcagta tgacctggcc ttggaagagg gcgaggggct ggcgcggctg 14280

ggggcgtcgt cgccggagcg gcacccgcgc gtgcagatga aaagggacgc tcgcgaggcc 14340

tacgtgccca agcagaacct gttcagagac aggagcggcg aggagcccga ggagatgcgc 14400

gcctcccgct tccacgcggg gcgggagctg cggcgcggcc tggaccgaaa gcgggtgctg 14460

agggacgagg atttcgaggc ggacgagctg acggggatca gccccgcgcg cgcgcacgtg 14520

gccgcggcca acctggtcac ggcgtacgag cagaccgtga aggaggagag caacttccaa 14580

aaatccttca acaaccacgt gcgcacgctg atcgcgcgcg aggaggtgac cctgggcctg 14640

atgcacctgt gggacctgct ggaggccatc gtgcagaacc ccacgagcaa gccgctgacg 14700

gcgcagctgt ttctggtggt gcagcacagt cgggacaacg agacgttcag ggaggcgctg 14760

ctgaatatca ccgagcccga gggccgctgg ctcctggacc tggtgaacat tctgcagagc 14820

atcgtggtgc aggagcgcgg gctgccgctg tccgagaagc tggcggccat caacttctcg 14880

gtgctgagcc tgggcaagta ctacgctagg aagatctaca agaccccgta cgtgcccata 14940

gacaaggagg tgaagatcga tgggttttac atgcgcatga ccctgaaagt gctgaccctg 15000

agcgacgatc tgggggtgta ccgcaacgac aggatgcacc gcgcggtgag cgccagccgc 15060

cggcgcgagc tgagcgacca ggagctgatg cacagcctgc agcgggccct gaccggggcc 15120

gggaccgagg gggagagcta ctttgacatg ggcgcggacc tgcgctggca gcccagccgc 15180

cgggccttgg aagctgccgg cggcgtgccc tacgtggagg aggtggacga tgaggaggag 15240

gagggcgagt acctggaaga ctgatggcgc gaccgtattt ttgctagatg cagcaacagc 15300

caccgccgcc gcctcctgat cccgcgatgc gggcggcgct gcagagccag ccgtccggca 15360

ttaactcctc ggacgattgg acccaggcca tgcaacgcat catggcgctg acgacccgca 15420

atcccgaagc ctttagacag cagcctcagg ccaaccggct ctcggccatc ctggaggccg 15480

tggtgccctc gcgctcgaac cccacgcacg agaaggtgct ggccatcgtg aacgcgctgg 15540

tggagaacaa ggccatccgc ggcgacgagg ccgggctggt gtacaacgcg ctgctggagc 15600

gcgtggcccg ctacaacagc accaacgtgc agacgaacct ggaccgcatg gtgaccgacg 15660

tgcgcgaggc ggtgtcgcag cgcgagcggt tccaccgcga gtcgaacctg ggctccatgg 15720

tggcgctgaa cgccttcctg agcacgcagc ccgccaacgt gccccggggc caggaggact 15780

acaccaactt catcagcgcg ctgcggctga tggtggccga ggtgccccag agcgaggtgt 15840

accagtcggg gccggactac ttcttccaga ccagtcgcca gggcttgcag accgtgaacc 15900

tgagccaggc tttcaagaac ttgcagggac tgtggggcgt gcaggccccg gtcggggacc 15960

gcgcgacggt gtcgagcctg ctgacgccga actcgcgcct gctgctgctg ctggtggcgc 16020

ccttcacgga cagcggcagc gtgagccgcg actcgtacct gggctacctg cttaacctgt 16080

accgcgaggc catcgggcag gcgcacgtgg acgagcagac ctaccaggag atcacccacg 16140

tgagccgcgc gctgggccag gaggacccgg gcaacctgga ggccaccctg aacttcctgc 16200

tgaccaaccg gtcgcagaag atcccgcccc agtacgcgct gagcaccgag gaggagcgca 16260

tcctgcgcta cgtgcagcag agcgtggggc tgttcttgat gcaggagggg gccacgccca 16320

gcgccgcgct cgacatgacc gcgcgcaaca tggagcccag catgtacgcc cgcaaccgcc 16380

cgttcatcaa taagctgatg gactacttgc atcgggcggc cgccatgaac tcggactact 16440

ttaccaacgc catcttgaac ccgcactggc tcccgccgcc cgggttctac acgggcgagt 16500

acgacatgcc cgaccccaac gacgggttcc tgtgggacga cgtggacagc agcgtgttct 16560

cgccgcggcc caccaccacc accgtgtgga agaaagaggg cggggaccgg cggccgtcct 16620

cggcgctgtc cggtcgcgcg ggtgctgccg cggcggtgcc cgaggctgcc agccccttcc 16680

cgagcctgcc cttttcgctg aacagcgtgc gcagcagcga gctgggtcgg ctgacgcggc 16740

cgcgcctgct gggcgaggag gagtacctga acgactcctt gttgaagccc gagcgcgaga 16800

agaacttccc caataacggg atagagagcc tggtggacaa gatgagccgc tggaagacgt 16860

acgcgcacga gcacagggac gagccccgag ctagcagcgc aggcacccgt agacgccagc 16920

ggcacgacag gcagcgggga ctggtgtggg acgatgagga ttccgccgac gacagcagcg 16980

tgttggactt gggtgggagt ggtggtggta acccgttcgc tcacctgcgc ccccgtatcg 17040

ggcgcctgat gtaagaatct gaaaaaataa aagacggtac tcaccaaggc catggcgacc 17100

agcgtgcgtt cttctctgtt gtttgtagta gtatgatgag gcgcgtgtac ccggagggtc 17160

ctcctccctc gtacgagagc gtgatgcagc aggcggtggc ggcggcgatg cagcccccgc 17220

tggaggcgcc ttacgtgccc ccgcggtacc tggcgcctac ggaggggcgg aacagcattc 17280

gttactcgga gctggcaccc ttgtacgata ccacccggtt gtacctggtg gacaacaagt 17340

cggcggacat cgcctcgctg aactaccaga acgaccacag caacttcctg accaccgtgg 17400

tgcagaacaa cgatttcacc cccacggagg ccagcaccca gaccatcaac tttgacgagc 17460

gctcgcggtg gggcggccag ctgaaaacca tcatgcacac caacatgccc aacgtgaacg 17520

agttcatgta cagcaacaag ttcaaggcgc gggtgatggt ctcgcgcaag acccccaacg 17580

gggtcacggt aggggatgat tatgatggta gtcaggacga gctgacctac gagtgggtgg 17640

agtttgagct gcccgagggc aacttctcgg tgaccatgac catcgatctg atgaacaacg 17700

ccatcatcga caactacttg gcggtggggc ggcagaacgg ggtgctggag agcgacatcg 17760

gcgtgaagtt cgacacgcgc aacttccggc tgggctggga ccccgtgacc gagctggtga 17820

tgccgggcgt gtacaccaac gaggccttcc accccgacat cgtcctgctg cccggctgcg 17880

gcgtggactt caccgagagc cgcctcagca acctgctggg catccgcaag cggcagccct 17940

tccaggaggg cttccagatc ctgtacgagg acctggaggg gggcaacatc cccgcgctct 18000

tggatgtcga agcctatgaa gaaagtaagg aaaaagcaga ggctgaggca actacagccg 18060

tggctaccgc cgcgactgtg gcagatgcca ctgtcaccag gggcgataca ttcgccaccc 18120

aggcggagga agcagccgcc ctagcggcga ccgatgatag tgaaagtaag atagtcatca 18180

agccggtgga gaaggacagc aagaacagga gctacaacgt tctaccggat ggaaagaaca 18240

ccgcctaccg cagctggtac ctggcctaca actacggcga ccccgagaag ggcgtgcgct 18300

cctggacgct gctcaccacc tcggacgtca cctgcggcgt ggagcaagtc tactggtcgc 18360

tgcccgacat gatgcaagac ccggtcacct tccgctccac gcgacaagtt agcaactacc 18420

cggtggtggg cgccgagctc ctgcccgtct actccaagag cttcttcaac gagcaggccg 18480

tctactcgca gcagctgcgt gccttcacct cgctcacgca cgtcttcaac cgcttccccg 18540

agaaccagat cctcgtccgc ccgcccgcgc ccaccattac caccgtcagt gaaaacgttc 18600

ctgctctcac agatcacggg accctgccgc tgcgcagcag tatccgggga gtccagcgcg 18660

tgaccgtcac tgacgccaga cgccgcacct gcccctacgt ctacaaggcc ctgggcgtag 18720

tcgcgccgcg cgtcctctcg agccgcacct tctaaaaaat gtccattctc atctcgccca 18780

gtaataacac cggttggggc ctgcgcgcgc ccagcaagat gtacggaggc gctcgccaac 18840

gctccacgca acaccccgtg cgcgtgcgcg ggcacttccg cgctccctgg ggcgccctca 18900

agggccgcgt gcgctcgcgc accaccgtcg acgacgtgat cgaccaggtg gtggccgacg 18960

cgcgcaacta cacgcccgcc gccgcgcccg cctccaccgt ggacgccgtc atcgacagcg 19020

tggtggccga cgcgcgccgg tacgcccgcg ccaagagccg gcggcggcgc atcgcccggc 19080

ggcaccggag cacccccgcc atgcgcgcgg cgcgagcctt gctgcgcagg gccaggcgca 19140

cgggacgcag ggccatgctc agggcggcca gacgcgcggc ctccggcagc agcagcgccg 19200

gcaggacccg cagacgcgcg gccacggcgg cggcggcggc catcgccagc atgtcccgcc 19260

cgcggcgcgg caacgtgtac tgggtgcgcg acgccgccac cggtgtgcgc gtgcccgtgc 19320

gcacccgccc ccctcgcact tgaagatgct gacttcgcga tgttgatgtg tcccagcggc 19380

gaggaggatg tccaagcgca aatacaagga agagatgctc caggtcatcg cgcctgagat 19440

ctacggcccc gcggcggcgg tgaaggagga aagaaagccc cgcaaactga agcgggtcaa 19500

aaaggacaaa aaggaggagg aagatgacgg actggtggag tttgtgcgcg agttcgcccc 19560

ccggcggcgc gtgcagtggc gcgggcggaa agtgaaaccg gtgctgcggc ccggcaccac 19620

ggtggtcttc acgcccggcg agcgttccgg ctccgcctcc aagcgctcct acgacgaggt 19680

gtacggggac gaggacatcc tcgagcaggc ggtcgagcgt ctgggcgagt ttgcttacgg 19740

caagcgcagc cgccccgcgc ccttgaaaga ggaggcggtg tccatcccgc tggaccacgg 19800

caaccccacg ccgagcctga agccggtgac cctgcagcag gtgctgccga gcgcggcgcc 19860

gcgccggggc ttcaagcgcg agggcggcga ggatctgtac ccgaccatgc agctgatggt 19920

gcccaagcgc cagaagctgg aggacgtgct ggagcacatg aaggtggacc ccgaggtgca 19980

gcccgaggtc aaggtgcggc ccatcaagca ggtggccccg ggcctgggcg tgcagaccgt 20040

ggacatcaag atccccacgg agcccatgga aacgcagacc gagcccgtga agcccagcac 20100

cagcaccatg gaggtgcaga cggatccctg gatgccagcg gcttccacca ccaccactcg 20160

ccgaagacgc aagtacggcg cggccagcct gctgatgccc aactacgcgc tgcatccttc 20220

catcatcccc acgccgggct accgcggcac gcgcttctac cgcggctaca ccagcagccg 20280

ccgccgcaag accaccaccc gccgccgtcg tcgcagccgc cgcagcagca ccgcgacttc 20340

cgccttggtg cggagagtgt atcgcagcgg gcgcgagcct ctgaccctgc cgcgcgcgcg 20400

ctaccacccg agcatcgcca tttaactacc gcctcctact tgcagatatg gccctcacat 20460

gccgcctccg cgtccccatt acgggctacc gaggaagaaa gccgcgccgt agaaggctga 20520

cggggaacgg gctgcgtcgc catcaccacc ggcggcggcg cgccatcagc aagcggttgg 20580

ggggaggctt cctgcccgcg ctgatcccca tcatcgccgc ggcgatcggg gcgatccccg 20640

gcatagcttc cgtggcggtg caggcctctc agcgccactg agaacacaaaa aagcatggat 20700

ttgtaataaa aaaatggact gacgctcctg gtcctgtgat gtgtgttttt agatggaaga 20760

catcaatttt tcgtccctgg caccgcgaca cggcacgcgg ccgtttatgg gcacctggag 20820

cgacatcggc aacagccaac tgaacggggg cgccttcaat tggagcagtc tctggagcgg 20880

gcttaagaat ttcgggtcca cgctcaaaac ctatggcaac aaggcgtgga acagcagcac 20940

agggcaggcg ctgagggaaa agctgaaaga gcagaacttc cagcagaagg tggtcgatgg 21000

cctggcctcg ggcatcaacg gggtggtgga cctggccaac caggccgtgc agaaacagat 21060

caacagccgc ctggacgcgg tcccgcccgc ggggtccgtg gagatgcccc aggtggagga 21120

ggagctgcct cccctggaca agcgcggcga caagcgaccg cgtcccgacg cggaggac 21180

gctgctgacg cacacggacg agccgccccc gtacgaggag gcggtgaaac tgggtctgcc 21240

caccacgcgg cccgtggcgc ctctggccac cggggtgctg aaacccagca gcagcagcca 21300

gcccgcgacc ctggacttgc ctccgcctgc ttcccgcccc tccacagtgg ctaagcccct 21360

gccgccggtg gccgtcgcgt cgcgcgcccc ccgaggccgc ccccaggcga actggcagag 21420

cactctgaac agcatcgtgg gtctgggagt gcagagtgtg aagcgccgcc gctgctatta 21480

aaagacactg tagcgcttaa cttgcttgtc tgtgtgtgta tatgtatgtc cgccgaccag 21540

aaggaggaag aggcgcgtcg ccgagttgca agatggccac cccatcgatg ctgccccagt 21600

gggcgtacat gcacatcgcc ggacaggacg cttcggagta cctgagtccg ggtctggtgc 21660

agttcgcccg cgccacagac acctacttca gtctggggaa caagtttagg aaccccacgg 21720

tggcgcccac gcacgatgtg accaccgacc gcagccagcg gctgacgctg cgcttcgtgc 21780

ccgtggaccg cgaggacaac acctactcgt acaaagtgcg ctacacgctg gccgtgggcg 21840

acaaccgcgt gctggacatg gccagcacct actttgacat ccgcggcgtg ctggatcggg 21900

gccccagctt caaaccctac tccggcaccg cctacaacag cctagctccc aagggagcgc 21960

ccaacacctc acagtggaag gattccgaca gcaaaatgca tacttttgga gttgctgcca 22020

tgcccggtgt tgttggtaaa aaaatagaag ccgatggtct gcctattgga atagattcat 22080

cctctggaac tgacaccata atttatgctg ataaaacttt ccaaccagag ccacaggttg 22140

gaagtgacag ttgggtcgac accaatggtg cagaggaaaa atatggaggt agagctctta 22200

aggacactac aaacatgaag ccctgctacg gttcttttgc caggcctacc aacaaagaag 22260

gtggacaggc taacataaaa gattctgaaa ctgccagcac tactcctaac tatgatatag 22320

atttggcatt ctttgacagc aaaaatattg cagctaacta cgatccagat attgtaatgt 22380

acacagaaaa tgttgagttg caaactccag atactcatat tgtgtttaag ccaggaactt 22440

cagatgaaag ttcagaagcc aatttgggcc agcaggccat gcccaacaga cccaactaca 22500

tcgggttcag agacaacttt atcgggctca tgtactacaa cagcactggc aatatgggtg 22560

tactggctgg tcaggcctcc cagctaaatg ctgtggtgga cttgcaggac agaaacaccg 22620

aactgtccta ccagctcttg cttgactctc tgggtgacag aaccaggtat ttcagtatgt 22680

ggaatcaggc ggtggacagc tatgaccccg atgtgcgcat tattgaaaat cacggtgtgg 22740

aggatgaact ccccaattat tgcttccctt tgaatggtgt aggctttaca gatacttacc 22800

agggtgttaa agttaagaca gatacagccg ctactggtac caatggaacg cagtgggaca 22860

aagatgatac cacagtcagc actgccaatg agatccactc aggcaatcct ttcgccatgg 22920

agatcaacat ccaggccaac ctgtggcgga acttcctcta cgcgaacgtg gcgctgtacc 22980

tgcccgactc ctacaagtac acgccggcca acatcacgct gccgaccaac accaacacct 23040

acgattacat gaacggccgc gtggtggcgc cctcgctggt ggacgcctac atcaacatcg 23100

gggcgcgctg gtcgctggac cccatggaca acgtcaaccc cttcaaccac caccgcaacg 23160

cgggcctgcg ctaccgctcc atgctcctgg gcaacgggcg ctacgtgccc ttccacatcc 23220

aggtgcccca aaagttttttc gccatcaaga gcctcctgct cctgcccggg tcctacacct 23280

acgagtggaa cttccgcaag gacgtcaaca tgatcctgca gagctccctc ggcaacgacc 23340

tgcgcacgga cggggcctcc atcgccttca ccagcatcaa cctctacgcc accttcttcc 23400

ccatggcgca caacaccgcc tccacgctcg aggccatgct gcgcaacgac accaacgacc 23460

agtccttcaa cgactacctc tcggcggcca acatgctcta ccccatcccg gccaacgcca 23520

ccaacgtgcc catctccatc ccctcgcgca actgggccgc cttccgcgga tggtccttca 23580

cgcgcctcaa gacccgcgag acgccctcgc tcggctccgg gttcgacccc tacttcgtct 23640

actcgggctc catcccctac ctcgacggca ccttctacct caaccacacc ttcaagaagg 23700

tctccatcac cttcgactcc tccgtcagct ggcccggcaa cgaccgcctc ctgacgccca 23760

acgagttcga aatcaagcgc accgtcgacg gagagggata caacgtggcc cagtgcaaca 23820

tgaccaagga ctggttcctg gtccagatgc tggcccacta caacatcggc taccagggct 23880

tctacgtgcc cgagggctac aaggaccgca tgtactcctt cttccgcaac ttccagccca 23940

tgagccgcca ggtcgtggac gaggtcaact acaaggacta ccaggccgtc accctggcct 24000

accagcacaa caactcgggc ttcgtcggct acctcgcgcc caccatgcgc cagggccagc 24060

cctaccccgc caactacccc tacccgctca tcggcaagag cgccgtcgcc agcgtcaccc 24120

agaaaaagtt cctctgcgac cgggtcatgt ggcgcatccc cttctccagc aacttcatgt 24180

ccatgggcgc gctcaccgac ctcggccaga acatgctcta cgccaactcc gcccacgcgc 24240

tagacatgaa tttcgaagtc gaccccatgg atgagtccac ccttctctat gttgtcttcg 24300

aagtcttcga cgtcgtccga gtgcaccagc cccaccgcgg cgtcatcgag gccgtctacc 24360

tgcgcacgcc cttctcggcc ggcaacgcca ccacctaaag ccccgctctt gcttcttgca 24420

agatgacggc ctgtggctcc ggcgagcagg agctcagggc catcctccgc gacctgggct 24480

gcgggccctg cttcctgggc accttcgaca agcgcttccc gggattcatg gccccgcaca 24540

agctggcctg cgccatcgtc aacacggccg gccgcgagac cgggggcgag cactggctgg 24600

ccttcgcctg gaacccgcgc tcccacacct gctacctctt cgaccccttc gggttctcgg 24660

acgagcgcct caagcagatc taccagttcg agtacgaggg cctgctgcgc cgcagcgccc 24720

tggccaccga ggaccgctgc atcaccctgg aaaagtccac ccagaccgtg cagggtccgc 24780

gctcggccgc ctgcgggctc ttctgctgca tgttcctgca cgccttcgtg cactggcccg 24840

accgccccat ggacaagaac cccaccatga acttgctgac gggggtgccc aacggcatgc 24900

tccagtcgcc ccaggtggaa cccaccctgc gccgcaacca ggaggcgctc taccgcttcc 24960

tcaacgccca ctccgcctac tttcgctccc accgcgcgcg catcgagaag gccaccgcct 25020

tcgaccgcat gaatcaagac atgtaaactg tgtgtatgtg aatgctttat tcatcataat 25080

aaacagcaca tgtttatgcc accttctctg aggctctgac tttatttaga aatcgaaggg 25140

gttctgccgg ctctcggcgt gccccgcggg cagggatacg ttgcggaact ggtacttggg 25200

cagccacttg aactcgggga tcagcagctt cggcacgggg aggtcgggga acgagtcgct 25260

ccacagcttg cgcgtgagtt gcagggcgcc cagcaggtcg ggcgcggaga tcttgaaatc 25320

gcagttggga cccgcgttct gcgcgcgaga gttgcggtac acggggttgc agcactggaa 25380

caccatcagg gccgggtgct tcacgctcgc cagcaccgtc gcgtcggtga tgccctccac 25440

gtccagatcc tcggcgttgg ccatcccgaa gggggtcatc ttgcaggtct gccgccccat 25500

gctgggcacg cagccgggct tgtggttgca atcgcagtgc agggggatca gcatcatctg 25560

agcctgctcg gagctcatgc ccgggtacat ggccttcatg aaagcctcca gctggcggaa 25620

ggcctgctgc gccttgccgc cctcggtgaa gaagacccca caggacttgc tagagaactg 25680

gttggtggcg cagcccgcgt cgtgcacgca gcagcgcgcg tcgttgttgg ccagctgcac 25740

cacgctgcgc ccccagcggt tctgggtgat cttggcccgg tcggggttct ccttcagcgc 25800

gcgctgcccg ttctcgctcg ccacatccat ctcgatcgtg tgctccttct ggatcatcac 25860

ggtcccgtgc aggcaccgca gcttgccctc ggcctcggtg cacccgtgca gccacagcgc 25920

gcagccggtg cactcccagt tcttgtgggc gatctgggag tgcgagtgca cgaagccctg 25980

caggaagcgg cccatcatcg tggtcagggt cttgttgctg gtgaaggtca gcgggatgcc 26040

gcggtgctcc tcgttcacat acaggtggca gatgcggcgg tacacctcgc cctgctcggg 26100

catcagctgg aaggcggact tcaggtcgct ctccacgcgg taccgctcca tcagcagcgt 26160

catcacttcc atgcccttct cccaggccga aacgatcggc aggctcaggg ggttcttcac 26220

cgtcatctta gtcgccgccg ccgaagtcag ggggtcgttc tcgtccaggg tctcaaacac 26280

tcgcttgccg tccttctcgg tgatgcgcac ggggggaaag ctgaagccca cggccgccag 26340

ctcctcctcg gcctgccttt cgtcctcgct gtcctggctg atgtcttgca aaggcacatg 26400

cttggtcttg cggggtttct ttttgggcgg cagaggcggc ggcggagacg tgctgggcga 26460

gcgcgagttc tcgctcacca cgactatttc ttcttcttgg ccgtcgtccg agaccacgcg 26520

gcggtaggca tgcctcttct ggggcagagg cggaggcgac gggctctcgc ggttcggcgg 26580

gcggctggca gagccccttc cgcgttcggg ggtgcgctcc tggcggcgct gctctgactg 26640

acttcctccg cggccggcca ttgtgttctc ctagggagca acaagcatgg agactcagcc 26700

atcgtcgcca acatcgccat ctgcccccgc cgccgacgag aaccagcagc agcagaatga 26760

aagcttaacc gccccgccgc ccagccccac ctccgacgcc gccgcggccc cagacatgca 26820

agagatggag gaatccatcg agattgacct gggctacgtg acgcccgcgg agcacgagga 26880

ggagctggca gcgcgctttt cagccccgga agagaaccac caagagcagc cagagcagga 26940

agcagagagc gagcagcagc aggctgggct cgagcatggc gactacctga gcggggcaga 27000

ggacgtgctc atcaagcatc tggcccgcca aagcatcatc gtcaaggacg cgctgctcga 27060

ccgcgccgag gtgcccctca gcgtggcgga gctcagccgc gcctacgagc gcaacctctt 27120

ctcgccgcgc gtgcccccca agcgccagcc caacggcacc tgcgagccca acccgcgcct 27180

caacttctac ccggtcttcg cggtgcccga ggccctggcc acctaccacc tctttttcaa 27240

gaaccaaagg atccccgtct cctgccgcgc caaccgcacc cgcgccgacg ccctgctcaa 27300

cctgggtccc ggcgcccgcc tacctgatat cacctccttg gaagaggttc ccaagatctt 27360

cgagggtctg ggcagcgacg agactcgggc cgcgaacgct ctgcaaggaa gcggagagga 27420

gcatgagcac cacagcgccc tggtggagtt ggaaggcgac aacgcgcgcc tggcggtgct 27480

caagcgcacg gtcgagctga cccacttcgc ctacccggcg ctcaacctgc cccccaaggt 27540

catgagcgcc gtcatggacc aggtgctcat caagcgcgcc tcgcccctct cagaggagga 27600

gatgcaggac cccgagagct cggacgaggg caagcccgtg gtcagcgacg agcagctggc 27660

gcgctggctg ggagcgagca gcacccccca gagcctggaa gagcggcgca agctcatgat 27720

ggccgtggtc ctggtgaccg tggagctgga gtgtctgcgc cgcttcttcg ccgacgcgga 27780

gaccctgcgc aaggtcgagg agaacctgca ctacctcttc aggcacgggt tcgtgcgcca 27840

ggcctgcaag atctccaacg tggagctgac caacctggtc tcctacatgg gcatcctgca 27900

cgagaaccgc ctggggcaga acgtgctgca caccaccctg cgcggggagg cccgccgcga 27960

ctacatccgc gactgcgtct acctgtacct ctgccacacc tggcagacgg gcatgggcgt 28020

gtggcagcag tgcctggagg agcagaacct gaaagagctc tgcaagctcc tgcagaagaa 28080

cctcaaggcc ctgtggaccg ggttcgacga gcgcaccacc gcctcggacc tggccgacct 28140

catcttcccc gagcgcctgc ggctgacgct gcgcaacggg ctgcccgact ttatgagcca 28200

aagcatgttg caaaactttc gctctttcat cctcgaacgc tccgggatcc tgcccgccac 28260

ctgctccgca ctgccctcgg acttcgtgcc gctgaccttc cgcgagtgcc ccccgccgct 28320

ctggagccac tgctacttgc tgcgcctggc caactacctg gcctaccact cggacgtgat 28380

cgaggacgtc agcagcgagg gtctgctcga gtgccactgc cgctgcaacc tctgcacgcc 28440

gcaccgctcc ttggcctgca acccccagct gctgagcgag acccagatca tcggcacctt 28500

cgagttgcaa ggccccggcg agggcaaggg gggtctcaaa ctcaccccgg ggctgtggac 28560

ctcggcctac ttgcgcaagt tcgtgcccga ggactaccat cccttcgaga tcaggttcta 28620

cgaggaccaa tcccagccgc ccaaggccga gctgtcggcc tgcgtcatca cccaggggggc 28680

catcctggcc caattgcaag ccatccagaa atcccgccaa gaatttctgc tgaaaaaggg 28740

ccacggggtc tacttggacc cccagaccgg agaggagctc aaccccagct tcccccagga 28800

tgccccgagg aagcagcaag aagctgaaag tggagctgcc gctgccgccg gaggatttgg 28860

aggaagactg ggagagcagt caggcagagg agatggaaga ctgggacagc actcaggcag 28920

aggaggacag cctgcaagac agtctggagg aggaagacga ggtggaggag gaggcagagg 28980

aagaagcagc cgccgccaga ccgtcgtcct cggcggagga gaaagcaagc agcacggata 29040

ccatctccgc tccgggtcgg ggtcgcggcg gccgggccca cagtagatgg gacgagaccg 29100

ggcgcttccc gaaccccacc acccagaccg gtaagaagga gcggcaggga tacaagtcct 29160

ggcgggggca caaaaacgcc atcgtctcct gcttgcaagc ctgcgggggc aacatctcct 29220

tcacccggcg ctacctgctc ttccaccgcg gggtgaactt cccccgcaac atcttgcatt 29280

actaccgtca cctccacagc ccctactact gtttccaaga agaggcagaa acccagcagc 29340

agcagcagaa aaccagcggc agcagcagca gctagaaaat ccacagcggc ggcaggtgga 29400

ctgaggatcg cggcgaacga gccggcgcag acccgggagc tgaggaaccg gatctttccc 29460

accctctatg ccatcttcca gcagagtcgg gggcaggagc aggaactgaa agtcaagaac 29520

cgttctctgc gctcgctcac ccgcagttgt ctgtatcaca agagcgaaga ccaacttcag 29580

cgcactctcg aggacgccga ggctctcttc aacaagtact gcgcgctcac tcttaaagag 29640

tagcccgcgc ccgcccacac acggaaaaag gcgggaatta cgtcaccacc tgcgcccttc 29700

gcccgaccat catcatgagc aaagagattc ccacgcctta catgtggagc taccagcccc 29760

agatgggcct ggccgccggc gccgcccagg actactccac ccgcatgaac tggctcagtg 29820

ccgggcccgc gatgatctca cgggtgaatg acatccgcgc ccaccgaaac cagatactcc 29880

tagaacagtc agcgatcacc gccacgcccc gccatcacct taatccgcgt aattggcccg 29940

ccgccctggt gtaccaggaa attccccagc ccacgaccgt actacttccg cgagacgccc 30000

aggccgaagt ccagctgact aactcaggtg tccagctggc cggcggcgcc gccctgtgtc 30060

gtcaccgccc cgctcagggt ataaagcggc tggtgatccg aggcagaggc acacagctca 30120

acgacgaggt ggtgagctct tcgctgggtc tgcgacctga cggagtcttc caactcgccg 30180

gatcggggag atcttccttc acgcctcgtc aggccgtcct gactttggag agttcgtcct 30240

cgcagccccg ctcgggcggc atcggcactc tccagttcgt ggaggaggttc actccctcgg 30300

tctacttcaa ccccttctcc ggctcccccg gccactaccc ggacgagttc atcccgaact 30360

tcgacgccat cagcgagtcg gtggacggct acgattgaat gtcccatggt ggcgcggctg 30420

acctagctcg gcttcgacac ctggaccact gccgccgctt ccgctgcttc gctcgggatc 30480

tcgccgagtt tgcctacttt gagctgcccg aggagcaccc tcagggcccg gcccacggag 30540

tgcggatcgt cgtcgaaggg ggcctcgact cccacctgct tcggattttc agccagcgtc 30600

cgatcctggt cgagcgcgag caaggacaga cccttctgac cctgtactgc atctgcaacc 30660

accccggcct gcatgaaagt ctttgttgtc tgctgtgtac tgagtataat aaaagctgag 30720

atcagcgact actccggact cgattgtggt gttcctgcta tcaaccggtc cctgttcttc 30780

accgggaacg agaccgagct ccagctccag tgtaagcccc acaagaagta tctcacctgg 30840

ctgttccagg gctctccgat cgccgttgtc aaccactgcg acaacgacgg agtcctgctg 30900

agcggccctg ccaaccttac tttttccacc cgcagaagca agctccagct cttccaaccc 30960

ttcctccccg ggacctatca gtgcgtctcg ggaccctgcc atcacacctt ccacctgatc 31020

ccgaatacca cagcgccgct ccccgctact aacaaccaaa ctacccacca acgccaccgt 31080

cgcgaccttt ctgaatctaa tactaccacc cacaccggag gtgagctccg aggtcgacca 31140

acctctggga tttactacgg ggttaacccc ttaattaagg ggattccata tggtacgtac 31200

atcgcctctc ctacgagctc ctgcagcagc gccagaagtt cacctgcctg gtcggagtca 31260

accccatcgt catcacccag cagtcgggcg ataccaaggg gtgcatccac tgctcctgcg 31320

actcccccga ctgcgtccac actctgatca agaccctctg cggcctccgc gacctcctcc 31380

ccatgaacta atcaccccct tatccagtga aataaagatc atattgatga tgattttaca 31440

gaaataaaga tacaatcata ttgatgattt gagtttaata aaaaataaag aatcacttac 31500

ttgaaatctg ataccaggtc tctgtccatg ttttctgcca acaccacttc actcccctct 31560

tcccagctct ggtactgcag gccccggcgg gctgcaaact tcctccacac gctgaagggg 31620

atgtcaaatt cctcctgtcc ctcaatcttc attttatctt ctatcagatg tccaaaaagc 31680

gcgtccgggt ggatgatgac ttcgaccccg tctaccccta cgatgcagac aacgcaccga 31740

ccgtgccctt catcaacccc cccttcgtct cttcagatgg attccaagag aagcccctgg 31800

gggtgctgtc cctgcgactg gccgaccccg tcaccaccaa gaacggggaa atcaccctca 31860

agctgggaga gggggtggac ctcgactcct cgggaaaact catctccaac acggccacca 31920

aggccgccgc ccctctcagt ttttccaaca acaccatttc ccttaacatg gatcacccct 31980

tttacactaa agatggaaaa ttatccttac aagtttctcc accattaaat atactgagaa 32040

caagcattct aaacacacta gctttaggtt ttggatcagg tttaggactc cgtggctctg 32100

ccttggcagt acagttagtc tctccactta catttgatac tgatggaaac ataaagctta 32160

ccttagacag aggtttgcat gttacaacag gagatgcaat tgaaagcaac ataagctggg 32220

ctaaaggttt aaaatttgaa gatggagcca tagcaaccaa cattggaaat gggttagagt 32280

ttggaagcag tagtacagaa acaggtgttg atgatgctta cccaatccaa gttaaacttg 32340

gatctggcct tagctttgac agtacaggag ccataatggc tggtaacaaa gaagacgata 32400

aactcacttt gtggacaaca cctgatccat cgccaaactg tcaaatactc gcagaaaatg 32460

atgcaaaact aacactttgc ttgactaaat gtggtagtca aatactggcc actgtgtcag 32520

tcttagttgt aggaagtgga aacctaaacc ccattactgg caccgtaagc agtgctcagg 32580

tgtttctacg ttttgatgca aacggtgttc ttttaacaga acattctaca ctaaaaaaat 32640

actgggggta taggcaggga gatagcatag atggcactcc atataccaat gctgtaggat 32700

tcatgcccaa tttaaaagct tatccaaagt cacaaagttc tactactaaa aataatatag 32760

tagggcaagt atacatgaat ggagatgttt caaaacctat gcttctcact ataaccctca 32820

atggtactga tgacagcaac agtacatatt caatgtcatt ttcatacacc tggactaatg 32880

gaagctatgt tggagcaaca tttggggcta actcttatac cttctcatac atcgcccaag 32940

aatgaacact gtatcccacc ctgcatgcca acccttccca ccccactctg tggaaaaaac 33000

tctgaaacac aaaataaaat aaagttcaag tgttttattg attcaacagt tttacaggat 33060

tcgagcagtt atttttcctc caccctccca ggacatggaa tacaccaccc tctccccccg 33120

cacagccttg aacatctgaa cgccattggt gatggacatg cttttggtct ccacgttcca 33180

cacagtttca gagcgagcca gtctcgggtc ggtcagggag atgaaaccct ccgggcacaa 33240

ttgggagaag tactcgccta ttatctggaa gaagcagaag agcggcggtg ggaatcatag 33300

tccgcgaacg ggatcggccg gtggtgtcgc atcaggcccc gcagcagtcg ctgccgccgc 33360

cgctccgtca agctgctgct cagggggtcc gggtccaggg actccctcag catgatgccc 33420

acggccctca gcatcagtcg tctggtgcgg cgggcgcagc agcgcatgcg gatctcgctc 33480

aggtcgctgc agtacgtgca acacagaacc accaggttgt tcaacagtcc atagttcaac 33540

acgctccagc cgaaactcat cgcgggaagg atgctaccca cgtggccgtc gtaccagatc 33600

ctcaggtaaa tcaagtggtg ccccctccag aacacgctgc ccacgtacat gatctccttg 33660

ggcatgtggc ggttcaccac ctcccggtac cacatcaccc tctggttgaa catgcagccc 33720

cggatgatcc tgcggaacca cagggccagc accgccccgc ccgccatgca gcgaagagac 33780

cccgggtccc ggcaatggca atggaggacc caccgctcgt acccgtggat catctgggag 33840

ctgaacaagt ctatgttggc acagcacagg catatgctca tgcatctctt cagcactctc 33900

aactcctcgg gggtcaaaac catatcccag ggcacgggga actcttgcag gacagcgaac 33960

cccgcagaac agggcaatcc tcgcacagaa cttacattgt gcatggacag ggtatcgcaa 34020

tcaggcagca ccgggtgatc ctccaccaga gaagcgcggg tctcggtctc ctcacagcgt 34080

ggtaaggggg ccggccgata cgggtgatgg cgggacgcgg ctgatcgtgt tcgcgaccgt 34140

gtcatgatgc agttgctttc ggacatattt cctgaagtct tggcgcgcca aagtctagac 34200

agcgtccata gcttaccgag cagcagcagc agcacacaac aggcgcaaga gtcagagaaa 34260

ggctgagctc taacctgtcc acccgctctc tgctcaatat atagcccaga tctacactga 34320

cgtaaaggcc aaagtctaaa aatacccgcc aaatagtcac acacgcccag cacacgccca 34380

gaaaccggtg acacactcaa aaaaatacgc gcacttcctc aaacgcccaa actgccgtca 34440

tttccgggtt cccacgctac gtcatcaaaa cacgactttc aaattccgtc gaccgttaaa 34500

aacgtcaccc gccccgcccc taacggtcgc ccgtctctca gccaatcagc gccccgcatc 34560

cccaaattca aacacctcat ttgcatatta acgcgcacca aaagtttgag gtatattatt 34620

gatgatgatt taaatggcgc gccgggcccg ggc 34653

<210> 16

<211> 32394

<212> DNA

<213> Artificial Sequence

<400> 16

aaatcatcat caataatata cctcaaactt ttggtgcgcg ttaatatgca aatgaggtgt 60

ttgaatttgg ggatgcgggg cgctgattgg ctgagagacg ggcgaccgtt aggggcgggg 120

cgggtgacgt tttgatgacg tggccgtgag gcggagccgg tttgcaagtt ctcgtgggaa 180

aagtgacgtc aaacgaggtg tggtttgaac acggaaatac tcaattttcc cgcgctctct 240

gacaggaaat gaggtgtttc tgggcggatg caagtgaaaa cgggccattt tcgcgcgaaa 300

actgaatgag gaagtgaaaa tctgagtaat tccgcgttta tggcagggag gagtatttgc 360

cgagggccga gtagactttg accgattacg tgggggtttc gattaccgta tttttcacct 420

aaatttccgc gtacggtgtc aaagtccggt gtttttacgt aggcgtcagc tgatcgccag 480

ggtatttaaa cctgcgctct ctagtcaaga ggccactctt gagtgccagc gagtagagtt 540

ttctcctccg cgccgcgagt cagatctaca ctttgaaagg cgatcgccga tatcatttcc 600

ccgaaaagtg ccacctgacc gtaactataa cggtcctaag gtagcgaaag ctcagatctc 660

ccgatcccct atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt 720

atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta 780

caacaaggca aggcttgacc gacaattgca tgaagaatct gcttagggtt aggcgttttg 840

cgctgcttcg cgatgtacgg gccagatata cgcgttgaca ttgattattg actagttatt 900

aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat 960

aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa 1020

taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg 1080

agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc 1140

cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct 1200

tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga 1260

tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa 1320

gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc 1380

caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg 1440

aggtctatat aagcagagct cgtttagtga accgtcagat cactagaagc tttattgcgg 1500

tagtttatca cagttaaatt gctaacgcag tcagtgcttc tgacacaaca gtctcgaact 1560

taagctgcag aagttggtcg tgaggcactg ggcaggtaag tatcaaggtt acaagacagg 1620

tttaaggaga ccaatagaaa ctgggcttgt cgagacagag aagactcttg cgtttctgat 1680

aggcacctat tggtcttact gacatccact ttgcctttct ctccacaggt gtccactccc 1740

agttcaatta cagctcttaa ggctagagta ctctagcccg ggatccaccg gtcgccacca 1800

tgtttcagga tccccaggag cggggccgca agctgccaca gctgtgcaca gagctccaga 1860

caaccattca cgatattatt ctcgagtgcg tctactgtaa gcagcagctc ctgcgccggg 1920

aggtctacga cttcgctaga cgcgacctgt gtatcgtcta ccgcgatgga aatccatacg 1980

ccgtcggcga taagtgcctc aagttttact ctaagatttc tgagtaccgg cactactgtt 2040

actcactgta cggaaccacc ctcgagcagc agtacaataa gcctctgtgt gatctgctca 2100

ttagatgcat taatggccag aagcctctct gtccagagga gaagcagcgg cacctcgata 2160

agaagcagcg gtttcacaat actaggggaa ggtggaccgg aaggtgtatg tcatgttgtc 2220

ggtcatcaag aactagacgc gagacacagc tcagaaagag gcgcgggtca ggcgcaccag 2280

tcaagcagac tctgaacttt gatctcctca agctcgctgg cgacgtcgag tctaatcctg 2340

gccccccacgg cgacacccca accctccacg agtacatgct ggatctccag cccgagacaa 2400

ccgacctcta cgggtacggg cagctcaatg attcatcaga ggaggaggat gagattgatg 2460

gccccgccgg acaggctgag cccgataggg cccactacaa tatcgtgaca ttttgttgca 2520

agggcgattc aacactccgc ctgtgcgtgc agtcaaccca cgtggatatt cggactctcg 2580

aggatctgct catgggaaca ctgggaattg tgtgccctat ttgttcccag aagcctagaa 2640

agaggcgcgg gtccggcgca acaaatttta gcctgctcaa gcaggctggc gacgtcgagg 2700

agaatcctgg gcccgctagg tttgaggatc caactagacg cgggtacaag ctccccgatc 2760

tgtgtacaga gctgaataca tcactccagg atattgagat tacttgcgtg tactgtaaga 2820

ccgtcctcga gctgactgag gtctttgagt tcgctagaaa ggatctcttc gtggtctacc 2880

gggattctat cccacacgcc gccggacaca agtgcattga cttttactct cgcattaggg 2940

agctcaggca ctactccgat agcgtctacg gggatacact ggagaagctg actaatactg 3000

gactgtacaa tctgctcatt agatgcctgc gcggacagaa gcctctcaat cccgctgaga 3060

agctgcggca cctgaatgag aagagacggt ttcacaatac cgccggacac taccggggcc 3120

agtgtcactc ttgttgtaat agggctaggc aggagcggct ccagagacgc cgcgagactc 3180

aggtccgcaa gaggcgcggg tccggcgcac ccgtgaagca gaccctgaac tttgatctcc 3240

tgaagctcgc tggggacgtg gagtctaacc ctgggccaca cggaccaaag gctaccctcc 3300

aggatatcgt cctgcacctc gagccacaga atgagattcc cgtcgacctg ctcggccacg 3360

gacagctgtc cgatagcgag gaggagaacg atgagattga tggggtgaat caccagcacc 3420

tgcccgctag acgcgccgag ccacagcggc acaccatgct gtgtatgtgt tgcaaggggg 3480

aggcacgcat cgagctggtg gtggagtctt ccgccgatga cctcagggct tttcagcagc 3540

tctttctgaa taccctgtcc ttcgtgtgcc cttggtgcgc ttcccagcag tgaagcggcc 3600

gccactgtgc tggatgatcc gagctcggta cctctagagt cgacccgggc ggccaaaccg 3660

ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt 3720

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat 3780

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag 3840

caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc 3900

ttctgaggcg gaaagaacca gcagatctgc agatctgaat tcatctatgt cgggtgcgga 3960

gaaagaggta atgaaatggc attatgggta ttatgggtct gcattaatga atcggccaga 4020

tatcgacata tgctggccac cgtacatgtg gcttcccatg ctcgcaagcc ctggcccgag 4080

ttcgagcaca atgtcatgac caggtgcaat atgcatctgg ggtcccggcg atcgcccgag 4140

gcatgttcat gccctaccag tgcaacatgc aatttgtgaa ggtgctgctg gagcccgatg 4200

ccatgtccag agtgagcctg acgggggtgt ttgacatgaa tgtggagctg tggaaaattc 4260

tgagatatga tgaatccaag accaggtgcc gggcctgcga atgcggaggc aagcacgcca 4320

ggcttcagcc cgtgtgtgtg gaggtgacgg aggacctgcg acccgatcat ttggtgttgt 4380

cctgcaacgg gacggagttc ggctccagcg gggaagaatc tgactagagt gagtagtgtt 4440

tgggggtggg tgggagcctg catgatgggc agaatgacta aaatctgtgt ttttctgtgt 4500

gttgcagcag catgagcgga agcgcctcct ttgagggagg ggtattcagc ccttatctga 4560

cggggcgtct cccctcctgg gcgggagtgc gtcagaatgt gatgggatcc acggtggacg 4620

gccggcccgt gcagcccgcg aactcttcaa ccctgaccta cgcgaccctg agctcctcgt 4680

ccgtggacgc agctgccgcc gcagctgctg cttccgccgc cagcgccgtg cgcggaatgg 4740

ccctgggcgc cggctactac agctctctgg tggccaactc gagttccacc aataatcccg 4800

ccagcctgaa cgaggagaag ctgttgctgc tgatggccca gctcgaggcc ctgacccagc 4860

gcctgggcga gctgacccag caggtggctc agctgcaggc ggagacgcgg gccgcggttg 4920

ccacggtgaa aaccaaataa aaaatgaatc aataaataaa cggagacggt tgttgatttt 4980

aacacagagt cttgaatctt tatttgattt ttcgcgcgcg gtaggccctg gaccaccggt 5040

ctcgatcatt gagcacccgg tggatctttt ccaggacccg gtagaggtgg gcttggatgt 5100

tgaggtacat gggcatgagc ccgtcccggg ggtggaggta gctccattgc agggcctcgt 5160

gctcgggggt ggtgttgtaa atcacccagt catagcaggg gcgcagggcg tggtgctgca 5220

cgatgtcttt gaggaggaga ctgatggcca cgggcagccc cttggtgtag gtgttgacga 5280

acctattgag ctgggaggga tgcatgcggg gggagatgag atgcatcttg gcctggatct 5340

tgagattggc gatgttcccg cccagatccc gccgggggtt catgttgtgc aggaccacca 5400

gcacggtgta tccggtgcac ttggggaatt tgtcatgcaa cttggaaggg aaggcgtgaa 5460

agaatttgga gacgcccttg tgaccgccca ggttttccat gcactcatcc atgatgatgg 5520

cgatggggccc gtgggcggcg gcctgggcaa agacgtttcg ggggtcggac acatcgtagt 5580

tgtggtcctg ggtgagctcg tcataggcca ttttaatgaa tttggggcgg agggtacccg 5640

actgggggac aaaggtgccc tcgatcccgg gggcgtagtt cccctcgcag atctgcatct 5700

cccaggcctt gagctcggag ggggggatca tgtccacctg cggggcgatg aaaaaaacgg 5760

tttccggggc gggggagatg agctgcgccg aaagcaggtt ccggagcagc tgggacttgc 5820

cgcagccggt ggggccgtag atgaccccga tgaccggctg caggtggtag ttgagggaga 5880

gacagctgcc gtcctcgcgg aggagggggg ccacctcgtt catcatctcg cgcacatgca 5940

tgttctcgcg cacgagttcc gccaggaggc gctcgccccc cagcgagagg agctcttgca 6000

gcgaggcgaa gtttttcagc ggcttgagcc cgtcggccat gggcattttg gagagggtct 6060

gttgcaagag ttccagacgg tcccaagagct cggtgatgtg ctctagggca tctcgatcca 6120

gcagacctcc tcgtttcgcg ggttggggcg actgcgggag tagggcacca ggcgatgggc 6180

gtccagcgag gccagggtcc ggtccttcca gggtcgcagg gtccgcgtca gcgtggtctc 6240

cgtcacggtg aaggggtgcg cgccgggctg ggcgcttgcg agggtgcgct tcaggctcat 6300

ccggctggtc gagaaccgct cccggtcggc gccctgcgcg tcggccaggt agcaattgag 6360

catgagttcg tagttgagcg cctcggccgc gtggcccttg gcgcggagct tacctttgga 6420

agtgtgtccg cagacgggac agaggaggga cttgagggcg tagagcttgg gggcgaggaa 6480

gacggactcg ggggcgtagg cgtccgcgcc gcagctggcg cagacggtct cgcactccac 6540

gagccaggtg aggtcggggc ggtcggggtc aaaaacgagg tttcctccgt gctttttgat 6600

gcgtttctta cctctggtct ccatgagctc gtgtccccgc tgggtgacaa agaggctgtc 6660

cgtgtccccg tagaccgact ttatgggccg gtcctcgagc ggggtgccgc ggtcctcgtc 6720

gtagaggaac cccgcccact ccgagacgaa ggcccgggtc caggccagca cgaaggaggc 6780

cacgtgggag gggtagcggt cgttgtccac cagcgggtcc accttctcca gggtatgcaa 6840

gcacatgtcc ccctcgtcca catccaggaa ggtgattggc ttgtaagtgt aggccacgtg 6900

accgggggtc ccggccgggg gggtataaaa gggggcgggc ccctgctcgt cctcactgtc 6960

ttccggatcg ctgtccagga gcgccagctg ttggggtagg tattccctct cgaaggcggg 7020

catgacctcg gcactcaggt tgtcagtttc tagaaacgag gaggatttga tattgacggt 7080

gccgttggag acgcctttca tgagcccctc gtccatctgg tcagaaaaga cgatcttttt 7140

gttgtcgagc ttggtggcga aggagccgta gagggcgttg gagagcagct tggcgatgga 7200

gcgcatggtc tggttctttt ccttgtcggc gcgctccttg gcggcgatgt tgagctgcac 7260

gtactcgcgc gccacgcact tccattcggg gaagacggtg gtgagctcgt cgggcacgat 7320

tctgacccgc cagccgcggt tgtgcagggt gatgaggtcc acgctggtgg ccacctcgcc 7380

gcgcaggggc tcgttggtcc agcagaggcg cccgcccttg cgcgagcaga aggggggcag 7440

cgggtccagc atgagctcgt cgggggggtc ggcgtccacg gtgaagatgc cgggcaggag 7500

ctcggggtcg aagtagctga tgcaggtgcc cagatcgtcc agacttgctt gccagtcgcg 7560

cacggccagc gcgcgctcgt aggggctgag gggcgtgccc cagggcatgg ggtgcgtgag 7620

cgcggaggcg tacatgccgc agatgtcgta gacgtagagg ggctcctgga ggacgccgat 7680

gtaggtgggg tagcagcgcc ccccgcggat gctggcgcgc acgtagtcgt acagctcgtg 7740

cgagggcgcg aggagccccg tgccgagatt ggagcgctgc ggcttttcgg cgcggtagac 7800

gatctggcgg aagatggcgt gggagttgga ggagatggtg ggcctctgga agatgttgaa 7860

gtgggcatgg ggcagtccga ccgagtccct gatgaagtgg gcgtaggagt cctgcagctt 7920

ggcgacgagc tcggcggtga cgaggacgtc cagggcgcag tagtcgaggg tctcttggat 7980

gatgtcgtac ttgagctggc ccttctgctt ccacagctcg cggttgagaa ggaactcttc 8040

gcggtccttc cagtactctt cgagggggaa cccgtcctga tcggcacggt aagagcccac 8100

catgtagaac tggttgacgg ccttgtaggc gcagcagccc ttctccacgg ggagggcgta 8160

agcttgcgcg gccttgcgca gggaggtgtg ggtgagggcg aaggtgtcgc gcaccatgac 8220

tttgaggaac tggtgcttga agtcgaggtc gtcgcagccg ccctgctccc agagctggaa 8280

gtccgtgcgc ttcttgtagg cggggttggg caaagcgaaa gtaacatcgt tgaagaggat 8340

cttgcccgcg cggggcatga agttgcgagt gatgcggaaa ggctggggca cctcggcccg 8400

gttgttgatg acctgggcgg cgaggacgat ctcgtcgaag ccgttgatgt tgtgcccgac 8460

gatgtagagt tccacgaatc gcgggcggcc cttgacgtgg ggcagcttct tgagctcgtc 8520

gtaggtgagc tcggcggggt cgctgagccc gtgctgctcg agggcccagt cggcgacgtg 8580

ggggttggcg ctgaggaagg aagtccagag atccacggcc agggcggtct gcaagcggtc 8640

ccggtactga cggaactgct ggcccacggc cattttttcg ggggtgacgc agtagaaggt 8700

gcgggggtcg ccgtgccagc ggtcccactt gagctggagg gcgaggtcgt gggcgagctc 8760

gacgagcggc gggtccccgg agagtttcat gaccagcatg aaggggacga gctgcttgcc 8820

gaaggacccc atccaggtgt aggtttccac atcgtaggtg aggaagagcc tttcggtgcg 8880

aggatgcgag ccgatgggga agaactggat ctcctgccac cagttggagg aatggctgtt 8940

gatgtgatgg aagtagaaat gccgacggcg cgccgagcac tcgtgcttgt gtttatacaa 9000

gcgtccgcag tgctcgcaac gctgcacggg atgcacgtgc tgcacgagct gtacctgggt 9060

tcctttgacg aggaatttca gtgggcagtg gagcgctggc ggctgcatct ggtgctgtac 9120

tacgtcctgg ccatcggcgt ggccatcgtc tgcctcgatg gtggtcatgc tgacgagccc 9180

gcgcgggagg caggtccaga cctcggctcg gacgggtcgg agagcgagga cgagggcgcg 9240

caggccggag ctgtccaggg tcctgagacg ctgcggagtc aggtcagtgg gcagcggcgg 9300

cgcgcggttg acttgcagga gcttttccag ggcgcgcggg aggtccagat ggtacttgat 9360

ctccacggcg ccgttggtgg cgacgtccac ggcttgcagg gtcccgtgcc cctggggcgc 9420

caccaccgtg ccccgtttct tcttgggcgg cggcggctcc atgcttagaa gcggcggcga 9480

ggacgcgcgc cgggcggcag gggcggctcg gggcccggag gcaggggcgg caggggcacg 9540

tcggcgccgc gcgcgggcag gttctggtac tgcgcccgga gaagactggc gtgagcgacg 9600

acgcgacggt tgacgtcctg gatctgacgc ctctgggtga aggccacggg acccgtgagt 9660

ttgaacctga aagagagttc gacagaatca atctcggtat cgttgacggc ggcctgccgc 9720

aggatctctt gcacgtcgcc cgagttgtcc tggtaggcga tctcggtcat gaactgctcg 9780

atctcctcct cctgaaggtc tccgcggccg gcgcgctcga cggtggccgc gaggtcgttg 9840

gagatgcggc ccatgagctg cgagaaggcg ttcatgccgg cctcgttcca gacgcggctg 9900

tagaccacgg ctccgtcggg gtcgcgcgcg cgcatgacca cctgggcgag gttgagctcg 9960

acgtggcgcg tgaagaccgc gtagttgcag aggcgctggt agaggtagtt gagcgtggtg 10020

gcgatgtgct cggtgacgaa gaagtacatg atccagcggc ggagcggcat ctcgctgacg 10080

tcgcccaggg cttccaagcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac 10140

tgggagttgc gcgccgagac ggtcaactcc tcctccagaa gacggatgag ctcggcgatg 10200

gtggcgcgca cctcgcgctc gaaggccccg gggggctcct cttccatttc ctcctcttcc 10260

tcctccacta acatctcttc tacttcctcc tcaggaggcg gcggcggggg aggggccctg 10320

cgtcgccggc ggcgcacggg cagacggtcg atgaagcgct cgatggtctc cccgcgccgg 10380

cgacgcatgg tctcggtgac ggcgcgcccg tcctcgcggg gccgcagcgt gaagacgccg 10440

ccgcgcatct ccaggtggcc gccggggggg tctccgttgg gcagggagag ggcgctgacg 10500

atgcatctta tcaattgacc cgtagggact ccgcgcaagg acctgagcgt ctcgagatcc 10560

acgggatccg aaaaccgctg aacgaaggct tcgagccagt cgcagtcgca aggtaggctg 10620

agcccggttt cttgttcttc gggtatttgg tcgggaggcg ggcgggcgat gctgctggtg 10680

atgaagttga agtaggcggt cctgagacgg cggatggtgg cgaggagcac caggtccttg 10740

ggcccggctt gctggatgcg cagacggtcg gccatgcccc aggcgtggtc ctgacacctg 10800

gcgaggtcct tgtagtagtc ctgcatgagc cgctccacgg gcacctcctc ctcgcccgcg 10860

cggccgtgca tgcgcgtgag cccgaacccg cgctgcggct ggacgagcgc caggtcggcg 10920

acgacgcgct cggcgaggat ggcctgctgg atctgggtga gggtggtctg gaagtcgtcg 10980

aagtcgacga agcggtggta ggctccggtg ttgatggtgt aggagcagtt ggccatgacg 11040

gaccagttga cggtctggtg gccggggcgc acgagctcgt ggtacttgag gcgcgagtag 11100

gcgcgcgtgt cgaagatgta gtcgttgcag gtgcgcacga ggtactggta tccgacgagg 11160

aagtgcggcg gcggctggcg gtagagcggc catcgctcgg tggcgggggc gccgggcgcg 11220

aggtcctcga gcatgaggcg gtggtagccg tagatgtacc tggacatcca ggtgatgccg 11280

gcggcggtgg tggaggcgcg cgggaactcg cggacgcggt tccagatgtt gcgcagcggc 11340

aggaagtagt tcatggtggc cgcggtctgg cccgtgaggc gcgcgcagtc gtggatgctc 11400

tagacatacg ggcaaaaacg aaagcggtca gcggctcgac tccgtggcct ggaggctaag 11460

cgaacgggtt gggctgcgcg tgtaccccgg ttcgaatctc gaatcaggct ggagccgcag 11520

ctaacgtggt actggcactc ccgtctcgac ccaagcctgc taacgaaacc tccaggatac 11580

ggaggcgggt cgtttttttgg ccttggtcgc tggtcatgaa aaactagtaa gcgcggaaag 11640

cggccgcccg cgatggctcg ctgccgtagt ctggagaaag aatcgccagg gttgcgttgc 11700

ggtgtgcccc ggttcgagcc tcagcgctcg gcgccggccg gattccgcgg ctaacgtggg 11760

cgtggctgcc ccgtcgtttc caagacccct tagccagccg acttctccag ttacggagcg 11820

agcccctctt ttttttcttgt gtttttgcca gatgcatccc gtactgcggc agatgcgccc 11880

ccaccctcca ccacaaccgc ccctaccgca gcagcagcaa cagccggcgc ttctgccccc 11940

gccccagcag cagcagccag ccactaccgc ggcggccgcc gtgagcggag ccggcgttca 12000

gtatgacctg gccttggaag agggcgaggg gctggcgcgg ctgggggcgt cgtcgccgga 12060

gcggcacccg cgcgtgcaga tgaaaaggga cgctcgcgag gcctacgtgc ccaagcagaa 12120

cctgttcaga gacaggagcg gcgaggagcc cgaggagatg cgcgcctccc gcttccacgc 12180

ggggcgggag ctgcggcgcg gcctggaccg aaagcgggtg ctgagggacg aggatttcga 12240

ggcggacgag ctgacgggga tcagccccgc gcgcgcgcac gtggccgcgg ccaacctggt 12300

cacggcgtac gagcagaccg tgaaggagga gagcaacttc caaaaatcct tcaacaacca 12360

cgtgcgcacg ctgatcgcgc gcgaggaggt gaccctgggc ctgatgcacc tgtgggacct 12420

gctggaggcc atcgtgcaga accccacgag caagccgctg acggcgcagc tgtttctggt 12480

ggtgcagcac agtcgggaca acgagacgtt cagggaggcg ctgctgaata tcaccgagcc 12540

cgagggccgc tggctcctgg acctggtgaa cattctgcag agcatcgtgg tgcaggagcg 12600

cgggctgccg ctgtccgaga agctggcggc catcaacttc tcggtgctga gcctgggcaa 12660

gtactacgct aggaagatct acaagacccc gtacgtgccc atagacaagg aggtgaagat 12720

cgatgggttt tacatgcgca tgaccctgaa agtgctgacc ctgagcgacg atctgggggt 12780

gtaccgcaac gacaggatgc accgcgcggt gagcgccagc cgccggcgcg agctgagcga 12840

ccaggagctg atgcacagcc tgcagcgggc cctgaccggg gccgggaccg agggggagag 12900

ctactttgac atgggcgcgg acctgcgctg gcagcccagc cgccgggcct tggaagctgc 12960

cggcggcgtg ccctacgtgg aggaggtgga cgatgaggag gaggagggcg agtacctgga 13020

agactgatgg cgcgaccgta tttttgctag atgcagcaac agccaccgcc gccgcctcct 13080

gatcccgcga tgcgggcggc gctgcagagc cagccgtccg gcattaactc ctcggacgat 13140

tggacccagg ccatgcaacg catcatggcg ctgacgaccc gcaatcccga agcctttaga 13200

cagcagcctc aggccaaccg gctctcggcc atcctggagg ccgtggtgcc ctcgcgctcg 13260

aaccccacgc acgagaaggt gctggccatc gtgaacgcgc tggtggagaa caaggccatc 13320

cgcggcgacg aggccgggct ggtgtacaac gcgctgctgg agcgcgtggc ccgctacaac 13380

agcaccaacg tgcagacgaa cctggaccgc atggtgaccg acgtgcgcga ggcggtgtcg 13440

cagcgcgagc ggttccaccg cgagtcgaac ctgggctcca tggtggcgct gaacgccttc 13500

ctgagcacgc agcccgccaa cgtgccccgg ggccaggagg actacaccaa cttcatcagc 13560

gcgctgcggc tgatggtggc cgaggtgccc cagagcgagg tgtaccagtc ggggccggac 13620

tacttcttcc agaccagtcg ccagggcttg cagaccgtga acctgagcca ggctttcaag 13680

aacttgcagg gactgtgggg cgtgcaggcc ccggtcgggg accgcgcgac ggtgtcgagc 13740

ctgctgacgc cgaactcgcg cctgctgctg ctgctggtgg cgcccttcac ggacagcggc 13800

agcgtgagcc gcgactcgta cctgggctac ctgcttaacc tgtaccgcga ggccatcggg 13860

caggcgcacg tggacgagca gacctaccag gagatcaccc acgtgagccg cgcgctgggc 13920

caggaggacc cgggcaacct ggaggccacc ctgaacttcc tgctgaccaa ccggtcgcag 13980

aagatcccgc cccagtacgc gctgagcacc gaggaggagc gcatcctgcg ctacgtgcag 14040

cagagcgtgg ggctgttctt gatgcaggag ggggccacgc ccagcgccgc gctcgacatg 14100

accgcgcgca acatggagcc cagcatgtac gcccgcaacc gcccgttcat caataagctg 14160

atggactact tgcatcgggc ggccgccatg aactcggact actttaccaa cgccatcttg 14220

aacccgcact ggctcccgcc gcccgggttc tacacgggcg agtacgacat gcccgacccc 14280

aacgacgggt tcctgtggga cgacgtggac agcagcgtgt tctcgccgcg gcccaccacc 14340

accaccgtgt ggaagaaaga gggcggggac cggcggccgt cctcggcgct gtccggtcgc 14400

gcgggtgctg ccgcggcggt gcccgaggct gccagcccct tcccgagcct gcccttttcg 14460

ctgaacagcg tgcgcagcag cgagctgggt cggctgacgc ggccgcgcct gctgggcgag 14520

gaggagtacc tgaacgactc cttgttgaag cccgagcgcg agaagaactt ccccaataac 14580

gggatagaga gcctggtgga caagatgagc cgctggaaga cgtacgcgca cgagcacagg 14640

gacgagcccc gagctagcag cgcaggcacc cgtagacgcc agcggcacga caggcagcgg 14700

ggactggtgt gggacgatga ggattccgcc gacgacagca gcgtgttgga cttgggtggg 14760

agtggtggtg gtaacccgtt cgctcacctg cgccccccgta tcgggcgcct gatgtaagaa 14820

tctgaaaaaa taaaagacgg tactcaccaa ggccatggcg accagcgtgc gttcttctct 14880

gttgtttgta gtagtatgat gaggcgcgtg tacccggagg gtcctcctcc ctcgtacgag 14940

agcgtgatgc agcaggcggt ggcggcggcg atgcagcccc cgctggaggc gccttacgtg 15000

cccccgcggt acctggcgcc tacggagggg cggaacagca ttcgttactc ggagctggca 15060

cccttgtacg ataccacccg gttgtacctg gtggacaaca agtcggcgga catcgcctcg 15120

ctgaactacc agaacgacca cagcaacttc ctgaccaccg tggtgcagaa caacgatttc 15180

acccccacgg aggccagcac ccagaccatc aactttgacg agcgctcgcg gtggggcggc 15240

cagctgaaaa ccatcatgca caccaacatg cccaacgtga acgagttcat gtacagcaac 15300

aagttcaagg cgcgggtgat ggtctcgcgc aagaccccca acggggtcac ggtaggggat 15360

gattatgatg gtagtcagga cgagctgacc tacgagtggg tggagtttga gctgcccgag 15420

ggcaacttct cggtgaccat gaccatcgat ctgatgaaca acgccatcat cgacaactac 15480

ttggcggtgg ggcggcagaa cggggtgctg gagagcgaca tcggcgtgaa gttcgacacg 15540

cgcaacttcc ggctgggctg ggaccccgtg accgagctgg tgatgccggg cgtgtacacc 15600

aacgaggcct tccaccccga catcgtcctg ctgcccggct gcggcgtgga cttcaccgag 15660

agccgcctca gcaacctgct gggcatccgc aagcggcagc ccttccagga gggcttccag 15720

atcctgtacg aggacctgga ggggggcaac atccccgcgc tcttggatgt cgaagcctat 15780

gaagaaagta aggaaaaagc agaggctgag gcaactacag ccgtggctac cgccgcgact 15840

gtggcagatg ccactgtcac caggggcgat acattcgcca cccaggcgga ggaagcagcc 15900

gccctagcgg cgaccgatga tagtgaaagt aagatagtca tcaagccggt ggagaaggac 15960

agcaagaaca ggagctacaa cgttctaccg gatggaaaga acaccgccta ccgcagctgg 16020

tacctggcct acaactacgg cgaccccgag aagggcgtgc gctcctggac gctgctcacc 16080

acctcggacg tcacctgcgg cgtggagcaa gtctactggt cgctgcccga catgatgcaa 16140

gacccggtca ccttccgctc cacgcgacaa gttagcaact acccggtggt gggcgccgag 16200

ctcctgcccg tctactccaa gagcttcttc aacgagcagg ccgtctactc gcagcagctg 16260

cgtgccttca cctcgctcac gcacgtcttc aaccgcttcc ccgagaacca gatcctcgtc 16320

cgcccgcccg cgcccaccat taccaccgtc agtgaaaacg ttcctgctct cacagatcac 16380

gggaccctgc cgctgcgcag cagtatccgg ggagtccagc gcgtgaccgt cactgacgcc 16440

agacgccgca cctgccccta cgtctacaag gccctgggcg tagtcgcgcc gcgcgtcctc 16500

tcgagccgca ccttctaaaa aatgtccatt ctcatctcgc ccagtaataa caccggttgg 16560

ggcctgcgcg cgcccagcaa gatgtacgga ggcgctcgcc aacgctccac gcaacacccc 16620

gtgcgcgtgc gcgggcactt ccgcgctccc tggggcgccc tcaagggccg cgtgcgctcg 16680

cgcaccaccg tcgacgacgt gatcgaccag gtggtggccg acgcgcgcaa ctacacgccc 16740

gccgccgcgc ccgcctccac cgtggacgcc gtcatcgaca gcgtggtggc cgacgcgcgc 16800

cggtacgccc gcgccaagag ccggcggcgg cgcatcgccc ggcggcaccg gagcaccccc 16860

gccatgcgcg cggcgcgagc cttgctgcgc agggccaggc gcacgggacg cagggccatg 16920

ctcagggcgg ccagacgcgc ggcctccggc agcagcagcg ccggcaggac ccgcagacgc 16980

gcggccacgg cggcggcggc ggccatcgcc agcatgtccc gcccgcggcg cggcaacgtg 17040

tactgggtgc gcgacgccgc caccggtgtg cgcgtgcccg tgcgcacccg cccccctcgc 17100

acttgaagat gctgacttcg cgatgttgat gtgtcccagc ggcgaggagg atgtccaagc 17160

gcaaatacaa ggaagagatg ctccaggtca tcgcgcctga gatctacggc cccgcggcgg 17220

cggtgaagga ggaaagaaag ccccgcaaac tgaagcgggt caaaaaggac aaaaaggagg 17280

aggaagatga cggactggtg gagtttgtgc gcgagttcgc cccccggcgg cgcgtgcagt 17340

ggcgcgggcg gaaagtgaaa ccggtgctgc ggcccggcac cacggtggtc ttcacgcccg 17400

gcgagcgttc cggctccgcc tccaagcgct cctacgacga ggtgtacggg gacgaggaca 17460

tcctcgagca ggcggtcgag cgtctgggcg agtttgctta cggcaagcgc agccgccccg 17520

cgcccttgaa agaggaggcg gtgtccatcc cgctggacca cggcaacccc acgccgagcc 17580

tgaagccggt gaccctgcag caggtgctgc cgagcgcggc gccgcgccgg ggcttcaagc 17640

gcgagggcgg cgaggatctg tacccgacca tgcagctgat ggtgcccaag cgccagaagc 17700

tggaggacgt gctggagcac atgaaggtgg accccgaggt gcagcccgag gtcaaggtgc 17760

ggcccatcaa gcaggtggcc ccgggcctgg gcgtgcagac cgtggacatc aagatcccca 17820

cggagcccat ggaaacgcag accgagcccg tgaagcccag caccagcacc atggaggtgc 17880

agacggatcc ctggatgcca gcggcttcca ccaccaccac tcgccgaaga cgcaagtacg 17940

gcgcggccag cctgctgatg cccaactacg cgctgcatcc ttccatcatc cccacgccgg 18000

gctaccgcgg cacgcgcttc taccgcggct acaccagcag ccgccgccgc aagaccacca 18060

cccgccgccg tcgtcgcagc cgccgcagca gcaccgcgac ttccgccttg gtgcggagag 18120

tgtatcgcag cgggcgcgag cctctgaccc tgccgcgcgc gcgctaccac ccgagcatcg 18180

ccatttaact accgcctcct acttgcagat atggccctca catgccgcct ccgcgtcccc 18240

attacgggct accgaggaag aaagccgcgc cgtagaaggc tgacggggaa cgggctgcgt 18300

cgccatcacc accggcggcg gcgcgccatc agcaagcggt tgggggggagg cttcctgccc 18360

gcgctgatcc ccatcatcgc cgcggcgatc ggggcgatcc ccggcatagc ttccgtggcg 18420

gtgcaggcct ctcagcgcca ctgagacaca aaaaagcatg gatttgtaat aaaaaaatgg 18480

actgacgctc ctggtcctgt gatgtgtgtt tttagatgga agacatcaat ttttcgtccc 18540

tggcaccgcg acacggcacg cggccgttta tgggcacctg gagcgacatc ggcaacagcc 18600

aactgaacgg gggcgccttc aattggagca gtctctggag cgggcttaag aatttcgggt 18660

ccacgctcaa aacctatggc aacaaggcgt ggaacagcag cacagggcag gcgctgaggg 18720

aaaagctgaa agagcagaac ttccagcaga aggtggtcga tggcctggcc tcgggcatca 18780

acggggtggt ggacctggcc aaccaggccg tgcagaaaca gatcaacagc cgcctggacg 18840

cggtcccgcc cgcggggtcc gtggagatgc cccaggtgga ggaggagctg cctcccctgg 18900

acaagcgcgg cgacaagcga ccgcgtcccg acgcggagga gacgctgctg acgcacacgg 18960

acgagccgcc cccgtacgag gaggcggtga aactgggtct gcccaccacg cggcccgtgg 19020

cgcctctggc caccggggtg ctgaaaccca gcagcagcag ccagcccgcg accctggact 19080

tgcctccgcc tgcttcccgc ccctccacag tggctaagcc cctgccgccg gtggccgtcg 19140

cgtcgcgcgc cccccgaggc cgcccccagg cgaactggca gagcactctg aacagcatcg 19200

tgggtctggg agtgcagagt gtgaagcgcc gccgctgcta ttaaaagaca ctgtagcgct 19260

taacttgctt gtctgtgtgt gtatatgtat gtccgccgac cagaaggagg aagaggcgcg 19320

tcgccgagtt gcaagatggc caccccatcg atgctgcccc agtgggcgta catgcacatc 19380

gccggacagg acgcttcgga gtacctgagt ccgggtctgg tgcagttcgc ccgcgccaca 19440

gacacctact tcagtctggg gaacaagttt aggaacccca cggtggcgcc cacgcacgat 19500

gtgaccaccg accgcagcca gcggctgacg ctgcgcttcg tgcccgtgga ccgcgaggac 19560

aacacctact cgtacaaagt gcgctacacg ctggccgtgg gcgacaaccg cgtgctggac 19620

atggccagca cctactttga catccgcggc gtgctggatc ggggccccag cttcaaaccc 19680

tactccggca ccgcctacaa cagcctagct cccaagggag cgcccaacac ctcacagtgg 19740

aaggattccg acagcaaaat gcatactttt ggagttgctg ccatgcccgg tgttgttggt 19800

aaaaaaatag aagccgatgg tctgcctatt ggaatagatt catcctctgg aactgacacc 19860

ataatttatg ctgataaaac tttccaacca gagccacagg ttggaagtga cagttgggtc 19920

gacaccaatg gtgcagagga aaaatatgga ggtagagctc ttaaggacac tacaaacatg 19980

aagccctgct acggttcttt tgccaggcct accaacaaag aaggtggaca ggctaacata 20040

aaagattctg aaactgccag cactactcct aactatgata tagatttggc attctttgac 20100

agcaaaaata ttgcagctaa ctacgatcca gatattgtaa tgtacacaga aaatgttgag 20160

ttgcaaactc cagatactca tattgtgttt aagccaggaa cttcagatga aagttcagaa 20220

gccaatttgg gccagcaggc catgcccaac agacccaact acatcgggtt cagagacaac 20280

tttatcgggc tcatgtacta caacagcact ggcaatatgg gtgtactggc tggtcaggcc 20340

tcccagctaa atgctgtggt ggacttgcag gacagaaaca ccgaactgtc ctaccagctc 20400

ttgcttgact ctctgggtga cagaaccagg tatttcagta tgtggaatca ggcggtggac 20460

agctatgacc ccgatgtgcg cattattgaa aatcacggtg tggaggatga actccccaat 20520

tattgcttcc ctttgaatgg tgtaggcttt acagatactt accagggtgt taaagttaag 20580

acagatacag ccgctactgg taccaatgga acgcagtggg acaaagatga taccacagtc 20640

agcactgcca atgagatcca ctcaggcaat cctttcgcca tggagatcaa catccaggcc 20700

aacctgtggc ggaacttcct ctacgcgaac gtggcgctgt acctgcccga ctcctacaag 20760

tacacgccgg ccaacatcac gctgccgacc aacaccaaca cctacgatta catgaacggc 20820

cgcgtggtgg cgccctcgct ggtggacgcc tacatcaaca tcggggcgcg ctggtcgctg 20880

gaccccatgg acaacgtcaa ccccttcaac caccaccgca acgcgggcct gcgctaccgc 20940

tccatgctcc tgggcaacgg gcgctacgtg cccttccaca tccaggtgcc ccaaaagttt 21000

ttcgccatca agagcctcct gctcctgccc gggtcctaca cctacgagtg gaacttccgc 21060

aaggacgtca acatgatcct gcagagctcc ctcggcaacg acctgcgcac ggacggggcc 21120

tccatcgcct tcaccagcat caacctctac gccaccttct tccccatggc gcacaacacc 21180

gcctccacgc tcgaggccat gctgcgcaac gacaccaacg accagtcctt caacgactac 21240

ctctcggcgg ccaacatgct ctaccccatc ccggccaacg ccaccaacgt gcccatctcc 21300

atcccctcgc gcaactgggc cgccttccgc ggatggtcct tcacgcgcct caagacccgc 21360

gagacgccct cgctcggctc cgggttcgac ccctacttcg tctactcggg ctccatcccc 21420

tacctcgacg gcaccttcta cctcaaccac accttcaaga aggtctccat caccttcgac 21480

tcctccgtca gctggcccgg caacgaccgc ctcctgacgc ccaacgagtt cgaaatcaag 21540

cgcaccgtcg acggagaggg atacaacgtg gcccagtgca acatgaccaa ggactggttc 21600

ctggtccaga tgctggccca ctacaacatc ggctaccagg gcttctacgt gcccgagggc 21660

tacaaggacc gcatgtactc cttcttccgc aacttccagc ccatgagccg ccaggtcgtg 21720

gacgaggtca actacaagga ctaccaggcc gtcaccctgg cctaccagca caacaactcg 21780

ggcttcgtcg gctacctcgc gcccaccatg cgccagggcc agccctaccc cgccaactac 21840

ccctacccgc tcatcggcaa gagcgccgtc gccagcgtca cccagaaaaa gttcctctgc 21900

gaccgggtca tgtggcgcat ccccttctcc agcaacttca tgtccatggg cgcgctcacc 21960

gacctcggcc agaacatgct ctacgccaac tccgcccacg cgctagacat gaatttcgaa 22020

gtcgacccca tggatgagtc cacccttctc tatgttgtct tcgaagtctt cgacgtcgtc 22080

cgagtgcacc agccccaccg cggcgtcatc gaggccgtct acctgcgcac gcccttctcg 22140

gccggcaacg ccaccaccta aagccccgct cttgcttctt gcaagatgac ggcctgtggc 22200

tccggcgagc aggagctcag ggccatcctc cgcgacctgg gctgcgggcc ctgcttcctg 22260

ggcaccttcg acaagcgctt cccgggattc atggccccgc acaagctggc ctgcgccatc 22320

gtcaacacgg ccggccgcga gaccgggggc gagcactggc tggccttcgc ctggaacccg 22380

cgctcccaca cctgctacct cttcgacccc ttcgggttct cggacgagcg cctcaagcag 22440

atctaccagt tcgagtacga gggcctgctg cgccgcagcg ccctggccac cgaggaccgc 22500

tgcatcaccc tggaaaagtc cacccagacc gtgcagggtc cgcgctcggc cgcctgcggg 22560

ctcttctgct gcatgttcct gcacgccttc gtgcactggc ccgaccgccc catggacaag 22620

aaccccacca tgaacttgct gacgggggtg cccaacggca tgctccagtc gccccaggtg 22680

gaacccaccc tgcgccgcaa ccaggaggcg ctctaccgct tcctcaacgc ccactccgcc 22740

tactttcgct cccaccgcgc gcgcatcgag aaggccaccg ccttcgaccg catgaatcaa 22800

gacatgtaaa ctgtgtgtat gtgaatgctt tattcatcat aataaacagc acatgtttat 22860

gccaccttct ctgaggctct gactttattt agaaatcgaa ggggttctgc cggctctcgg 22920

cgtgccccgc gggcagggat acgttgcgga actggtactt gggcagccac ttgaactcgg 22980

ggatcagcag cttcggcacg gggaggtcgg ggaacgagtc gctccacagc ttgcgcgtga 23040

gttgcagggc gcccagcagg tcgggcgcgg agatcttgaa atcgcagttg ggacccgcgt 23100

tctgcgcgcg agagttgcgg tacacggggt tgcagcactg gaacaccatc agggccgggt 23160

gcttcacgct cgccagcacc gtcgcgtcgg tgatgccctc cacgtccaga tcctcggcgt 23220

tggccatccc gaagggggtc atcttgcagg tctgccgccc catgctgggc acgcagccgg 23280

gcttgtggtt gcaatcgcag tgcaggggga tcagcatcat ctgagcctgc tcggagctca 23340

tgcccgggta catggccttc atgaaagcct ccagctggcg gaaggcctgc tgcgccttgc 23400

cgccctcggt gaagaagacc ccacaggact tgctagagaa ctggttggtg gcgcagcccg 23460

cgtcgtgcac gcagcagcgc gcgtcgttgt tggccagctg caccacgctg cgcccccagc 23520

ggttctgggt gatcttggcc cggtcggggt tctccttcag cgcgcgctgc ccgttctcgc 23580

tcgccacatc catctcgatc gtgtgctcct tctggatcat cacggtcccg tgcaggcacc 23640

gcagcttgcc ctcggcctcg gtgcacccgt gcagccacag cgcgcagccg gtgcactccc 23700

agttcttgtg ggcgatctgg gagtgcgagt gcacgaagcc ctgcaggaag cggcccatca 23760

tcgtggtcag ggtcttgttg ctggtgaagg tcagcgggat gccgcggtgc tcctcgttca 23820

catacaggtg gcagatgcgg cggtacacct cgccctgctc gggcatcagc tggaaggcgg 23880

acttcaggtc gctctccacg cggtaccgct ccatcagcag cgtcatcact tccatgccct 23940

tctcccaggc cgaaacgatc ggcaggctca gggggttctt caccgtcatc ttagtcgccg 24000

ccgccgaagt cagggggtcg ttctcgtcca gggtctcaaa cactcgcttg ccgtccttct 24060

cggtgatgcg cacggggggga aagctgaagc ccacggccgc cagctcctcc tcggcctgcc 24120

tttcgtcctc gctgtcctgg ctgatgtctt gcaaaggcac atgcttggtc ttgcggggtt 24180

tctttttggg cggcagaggc ggcggcggag acgtgctggg cgagcgcgag ttctcgctca 24240

ccacgactat ttcttcttct tggccgtcgt ccgagaccac gcggcggtag gcatgcctct 24300

tctggggcag aggcggaggc gacgggctct cgcggttcgg cgggcggctg gcagagcccc 24360

ttccgcgttc gggggtgcgc tcctggcggc gctgctctga ctgacttcct ccgcggccgg 24420

ccattgtgtt ctcctaggga gcaacaagca tggagactca gccatcgtcg ccaacatcgc 24480

catctgcccc cgccgccgac gagaaccagc agcagcagaa tgaaagctta accgccccgc 24540

cgcccagccc cacctccgac gccgccgcgg ccccagacat gcaagagatg gaggaatcca 24600

tcgagattga cctgggctac gtgacgcccg cggagcacga ggaggagctg gcagcgcgct 24660

tttcagcccc ggaagagaac caccaagagc agccagagca ggaagcagag agcgagcagc 24720

agcaggctgg gctcgagcat ggcgactacc tgagcggggc agaggacgtg ctcatcaagc 24780

atctggcccg ccaaagcatc atcgtcaagg acgcgctgct cgaccgcgcc gaggtgcccc 24840

tcagcgtggc ggagctcagc cgcgcctacg agcgcaacct cttctcgccg cgcgtgcccc 24900

ccaagcgcca gcccaacggc acctgcgagc ccaacccgcg cctcaacttc tacccggtct 24960

tcgcggtgcc cgaggccctg gccacctacc acctcttttt caagaaccaa aggatccccg 25020

tctcctgccg cgccaaccgc acccgcgccg acgccctgct caacctgggt cccggcgccc 25080

gcctacctga tatcacctcc ttggaagagg ttcccaagat cttcgagggt ctgggcagcg 25140

acgagactcg ggccgcgaac gctctgcaag gaagcggaga ggagcatgag caccacagcg 25200

ccctggtgga gttggaaggc gacaacgcgc gcctggcggt gctcaagcgc acggtcgagc 25260

tgacccactt cgcctacccg gcgctcaacc tgcccccccaa ggtcatgagc gccgtcatgg 25320

accaggtgct catcaagcgc gcctcgcccc tctcagagga ggagatgcag gaccccgaga 25380

gctcggacga gggcaagccc gtggtcagcg acgagcagct ggcgcgctgg ctgggagcga 25440

gcagcacccc ccagagcctg gaagagcggc gcaagctcat gatggccgtg gtcctggtga 25500

ccgtggagct ggagtgtctg cgccgcttct tcgccgacgc ggagaccctg cgcaaggtcg 25560

aggagaacct gcactacctc ttcaggcacg ggttcgtgcg ccaggcctgc aagatctcca 25620

acgtggagct gaccaacctg gtctcctaca tgggcatcct gcacgagaac cgcctggggc 25680

agaacgtgct gcacaccacc ctgcgcgggg aggcccgccg cgactacatc cgcgactgcg 25740

tctacctgta cctctgccac acctggcaga cgggcatggg cgtgtggcag cagtgcctgg 25800

aggagcagaa cctgaaagag ctctgcaagc tcctgcagaa gaacctcaag gccctgtgga 25860

ccgggttcga cgagcgcacc accgcctcgg acctggccga cctcatcttc cccgagcgcc 25920

tgcggctgac gctgcgcaac gggctgcccg actttatgag ccaaagcatg ttgcaaaact 25980

ttcgctcttt catcctcgaa cgctccggga tcctgcccgc cacctgctcc gcactgccct 26040

cggacttcgt gccgctgacc ttccgcgagt gccccccgcc gctctggagc cactgctact 26100

tgctgcgcct ggccaactac ctggcctacc actcggacgt gatcgaggac gtcagcagcg 26160

agggtctgct cgagtgccac tgccgctgca acctctgcac gccgcaccgc tccttggcct 26220

gcaaccccca gctgctgagc gagacccaga tcatcggcac cttcgagttg caaggccccg 26280

gcgagggcaa ggggggtctc aaactcaccc cggggctgtg gacctcggcc tacttgcgca 26340

agttcgtgcc cgaggactac catcccttcg agatcaggtt ctacgaggac caatcccagc 26400

cgcccaaggc cgagctgtcg gcctgcgtca tcacccaggg ggccatcctg gcccaattgc 26460

aagccatcca gaaatcccgc caagaatttc tgctgaaaaa gggccacggg gtctacttgg 26520

acccccagac cggagaggag ctcaacccca gcttccccca ggatgccccg aggaagcagc 26580

aagaagctga aagtggagct gccgctgccg ccggaggatt tggaggaaga ctgggagagc 26640

agtcaggcag aggagatgga agactgggac agcactcagg cagaggagga cagcctgcaa 26700

gacagtctgg aggaggaaga cgaggtggag gaggaggcag aggaagaagc agccgccgcc 26760

agaccgtcgt cctcggcgga ggagaaagca agcagcacgg ataccatctc cgctccgggt 26820

cggggtcgcg gcggccgggc ccacagtaga tgggacgaga ccgggcgctt cccgaacccc 26880

accacccaga ccggtaagaa ggagcggcag ggatacaagt cctggcgggg gcacaaaaac 26940

gccatcgtct cctgcttgca agcctgcggg ggcaacatct ccttcacccg gcgctacctg 27000

ctcttccacc gcggggtgaa cttccccccgc aacatcttgc attactaccg tcacctccac 27060

agcccctact actgtttcca agaagaggca gaaacccagc agcagcagca gaaaaccagc 27120

ggcagcagca gcagctagaa aatccacagc ggcggcaggt ggactgagga tcgcggcgaa 27180

cgagccggcg cagacccggg agctgaggaa ccggatcttt cccaccctct atgccatctt 27240

ccagcagagt cgggggcagg agcaggaact gaaagtcaag aaccgttctc tgcgctcgct 27300

cacccgcagt tgtctgtatc acaagagcga agaccaactt cagcgcactc tcgaggacgc 27360

cgaggctctc ttcaacaagt actgcgcgct cactcttaaa gagtagcccg cgcccgccca 27420

cacacggaaa aaggcgggaa ttacgtcacc acctgcgccc ttcgcccgac catcatcatg 27480

agcaaagaga ttcccacgcc ttacatgtgg agctaccagc cccagatggg cctggccgcc 27540

ggcgccgccc aggactactc cacccgcatg aactggctca gtgccgggcc cgcgatgatc 27600

tcacgggtga atgacatccg cgcccaccga aaccagatac tcctagaaca gtcagcgatc 27660

accgccacgc cccgccatca ccttaatccg cgtaattggc ccgccgccct ggtgtaccag 27720

gaaattcccc agcccacgac cgtactactt ccgcgagacg cccaggccga agtccagctg 27780

actaactcag gtgtccagct ggccggcggc gccgccctgt gtcgtcaccg ccccgctcag 27840

ggtataaagc ggctggtgat ccgaggcaga ggcacacagc tcaacgacga ggtggtgagc 27900

tcttcgctgg gtctgcgacc tgacggagtc ttccaactcg ccggatcggg gagatcttcc 27960

ttcacgcctc gtcaggccgt cctgactttg gagagttcgt cctcgcagcc ccgctcgggc 28020

ggcatcggca ctctccagtt cgtggaggag ttcactccct cggtctactt caaccccttc 28080

tccggctccc ccggccacta cccggacgag ttcatcccga acttcgacgc catcagcgag 28140

tcggtggacg gctacgattg aatgtcccat ggtggcgcgg ctgacctagc tcggcttcga 28200

cacctggacc actgccgccg cttccgctgc ttcgctcggg atctcgccga gtttgcctac 28260

tttgagctgc ccgaggagca ccctcagggc ccggcccacg gagtgcggat cgtcgtcgaa 28320

gggggcctcg actcccacct gcttcggatt ttcagccagc gtccgatcct ggtcgagcgc 28380

gagcaaggac agacccttct gaccctgtac tgcatctgca accaccccgg cctgcatgaa 28440

agtctttgtt gtctgctgtg tactgagtat aataaaagct gagatcagcg actactccgg 28500

actcgattgt ggtgttcctg ctatcaaccg gtccctgttc ttcaccggga acgagaccga 28560

gctccagctc cagtgtaagc cccacaagaa gtatctcacc tggctgttcc agggctctcc 28620

gatcgccgtt gtcaaccact gcgacaacga cggagtcctg ctgagcggcc ctgccaacct 28680

tactttttcc acccgcagaa gcaagctcca gctcttccaa cccttcctcc ccgggaccta 28740

tcagtgcgtc tcgggaccct gccatcacac cttccacctg atcccgaata ccacagcgcc 28800

gctccccgct actaacaacc aaactaccca ccaacgccac cgtcgcgacc tttctgaatc 28860

taatactacc acccacaccg gaggtgagct ccgaggtcga ccaacctctg ggatttacta 28920

cggggttaac cccttaatta aggggattcc atatggtacg tacatcgcct ctcctacgag 28980

ctcctgcagc agcgccagaa gttcacctgc ctggtcggag tcaaccccat cgtcatcacc 29040

cagcagtcgg gcgataccaa ggggtgcatc cactgctcct gcgactcccc cgactgcgtc 29100

cacactctga tcaagaccct ctgcggcctc cgcgacctcc tccccatgaa ctaatcaccc 29160

ccttatccag tgaaataaag atcatattga tgatgatttt acagaaataa agatacaatc 29220

atattgatga tttgagttta ataaaaaata aagaatcact tacttgaaat ctgataccag 29280

gtctctgtcc atgttttctg ccaacaccac ttcactcccc tcttcccagc tctggtactg 29340

caggccccgg cgggctgcaa acttcctcca cacgctgaag gggatgtcaa attcctcctg 29400

tccctcaatc ttcattttat cttctatcag atgtccaaaa agcgcgtccg ggtggatgat 29460

gacttcgacc ccgtctaccc ctacgatgca gacaacgcac cgaccgtgcc cttcatcaac 29520

ccccccttcg tctcttcaga tggattccaa gagaagcccc tgggggtgct gtccctgcga 29580

ctggccgacc ccgtcaccac caagaacggg gaaatcaccc tcaagctggg agagggggtg 29640

gacctcgact cctcgggaaa actcatctcc aacacggcca ccaaggccgc cgcccctctc 29700

agtttttcca acaacaccat ttcccttaac atggatcacc ccttttacac taaagatgga 29760

aaattatcct tacaagtttc tccaccatta aatatactga gaacaagcat tctaaacaca 29820

ctagctttag gttttggatc aggtttagga ctccgtggct ctgccttggc agtacagtta 29880

gtctctccac ttacatttga tactgatgga aacataaagc ttaccttaga cagaggtttg 29940

catgttacaa caggagatgc aattgaaagc aacataagct gggctaaagg tttaaaattt 30000

gaagatggag ccatagcaac caacattgga aatgggttag agtttggaag cagtagtaca 30060

gaaacaggtg ttgatgatgc ttacccaatc caagttaaac ttggatctgg ccttagcttt 30120

gacagtacag gagccataat ggctggtaac aaagaagacg ataaactcac tttgtggaca 30180

acacctgatc catcgccaaa ctgtcaaata ctcgcagaaa atgatgcaaa actaacactt 30240

tgcttgacta aatgtggtag tcaaatactg gccactgtgt cagtcttagt tgtaggaagt 30300

ggaaacctaa accccattac tggcaccgta agcagtgctc aggtgtttct acgttttgat 30360

gcaaacggtg ttcttttaac agaacattct acactaaaaa aatactgggg gtataggcag 30420

ggagatagca tagatggcac tccatatacc aatgctgtag gattcatgcc caatttaaaa 30480

gcttatccaa agtcacaaag ttctactact aaaaataata tagtagggca agtatacatg 30540

aatggagatg tttcaaaacc tatgcttctc actataaccc tcaatggtac tgatgacagc 30600

aacagtacat attcaatgtc attttcatac acctggacta atggaagcta tgttggagca 30660

acatttgggg ctaactctta taccttctca tacatcgccc aagaatgaac actgtatccc 30720

accctgcatg ccaacccttc ccaccccact ctgtggaaaa aactctgaaa cacaaaataa 30780

aataaagttc aagtgtttta ttgattcaac agttttacag gattcgagca gttatttttc 30840

ctccaccctc ccaggacatg gaatacacca ccctctcccc ccgcacagcc ttgaacatct 30900

gaacgccatt ggtgatggac atgcttttgg tctccacgtt ccacacagtt tcagagcgag 30960

ccagtctcgg gtcggtcagg gagatgaaac cctccgggca caattgggag aagtactcgc 31020

ctattatctg gaagaagcag aagagcggcg gtgggaatca tagtccgcga acgggatcgg 31080

ccggtggtgt cgcatcaggc cccgcagcag tcgctgccgc cgccgctccg tcaagctgct 31140

gctcagggggg tccgggtcca gggactccct cagcatgatg cccacggccc tcagcatcag 31200

tcgtctggtg cggcgggcgc agcagcgcat gcggatctcg ctcaggtcgc tgcagtacgt 31260

gcaacacaga accaccaggt tgttcaacag tccatagttc aacacgctcc agccgaaact 31320

catcgcggga aggatgctac ccacgtggcc gtcgtaccag atcctcaggt aaatcaagtg 31380

gtgccccctc cagaacacgc tgcccacgta catgatctcc ttgggcatgt ggcggttcac 31440

cacctcccgg taccacatca ccctctggtt gaacatgcag ccccggatga tcctgcggaa 31500

ccacagggcc agcaccgccc cgcccgccat gcagcgaaga gaccccgggt cccggcaatg 31560

gcaatggagg acccaccgct cgtacccgtg gatcatctgg gagctgaaca agtctatgtt 31620

ggcacagcac aggcatatgc tcatgcatct cttcagcact ctcaactcct cgggggtcaa 31680

aaccatatcc cagggcacgg ggaactcttg caggacagcg aaccccgcag aacagggcaa 31740

tcctcgcaca gaacttacat tgtgcatgga cagggtatcg caatcaggca gcaccgggtg 31800

atcctccacc agagaagcgc gggtctcggt ctcctcacag cgtggtaagg gggccggccg 31860

atacgggtga tggcgggacg cggctgatcg tgttcgcgac cgtgtcatga tgcagttgct 31920

ttcggacata tttcctgaag tcttggcgcg ccaaagtcta gacagcgtcc atagcttacc 31980

gagcagcagc agcagcacac aacaggcgca agagtcagag aaaggctgag ctctaacctg 32040

tccacccgct ctctgctcaa tatatagccc agatctacac tgacgtaaag gccaaagtct 32100

aaaaataccc gccaaatagt cacacacgcc cagcacacgc ccagaaaccg gtgacacact 32160

caaaaaaata cgcgcacttc ctcaaacgcc caaactgccg tcatttccgg gttcccacgc 32220

tacgtcatca aaacacgact ttcaaattcc gtcgaccgtt aaaaacgtca cccgccccgc 32280

ccctaacggt cgcccgtctc tcagccaatc agcgccccgc atccccaaat tcaaacacct 32340

catttgcata ttaacgcgca ccaaaagttt gaggtatatt attgatgatg attt 32394

<210> 17

<211> 35669

<212> DNA

<213> Artificial Sequence

<400> 17

cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg 60

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca 120

gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt 180

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg 240

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct 300

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat 360

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc 420

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg 480

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg 540

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga 600

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta 660

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc 720

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc 780

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg 840

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc 900

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca 960

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct 1020

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat 1080

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg 1140

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat 1200

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact 1260

tcatttttaa tttaaaagga tctaggtgaa gatcctttttt gataatctca tgaccaaaat 1320

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc 1380

ttcttgagat ccttttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct 1440

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg 1500

cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca 1560

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc 1620

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga 1680

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac 1740

gacctacacc gaactgagat acctacagcg tgagctttga gatagcgcca cgcttcccga 1800

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag 1860

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg 1920

acttgagcgt cgattttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag 1980

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc 2040

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc 2100

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc 2160

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag 2220

gtttcccgac tggatttaaa tcatcatcaa taatatacct caaacttttg gtgcgcgtta 2280

atatgcaaat gaggtgtttg aatttgggga tgcggggcgc tgattggctg agagacgggc 2340

gaccgttagg ggcggggcgg gtgacgtttt gatgacgtgg ccgtgaggcg gagccggttt 2400

gcaagttctc gtgggaaaag tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca 2460

attttcccgc gctctctgac aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg 2520

gccattttcg cgcgaaaact gaatgaggaa gtgaaaatct gagtaattcc gcgtttatgg 2580

cagggaggag tatttgccga gggccgagta gactttgacc gattacgtgg gggtttcgat 2640

taccgtattt ttcacctaaa tttccgcgta cggtgtcaaa gtccggtgtt tttacgtagg 2700

cgtcagctga tcgccagggt atttaaacct gcgctctcta gtcaagaggc cactcttgag 2760

tgccagcgag tagagttttc tcctccgcgc cgcgagtcag atctacactt tgaaaggcga 2820

tcgccgatat catttccccg aaaagtgcca cctgaccgta actataacgg tcctaaggta 2880

gcgaaagctc agatctcccg atcccctatg gtgcactctc agtacaatct gctctgatgc 2940

cgcatagtta agccagtatc tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc 3000

gagcaaaatt taagctacaa caaggcaagg cttgaccgac aattgcatga agaatctgct 3060

tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc agatatacgc gttgacattg 3120

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat 3180

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc 3240

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca 3300

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta 3360

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta 3420

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat 3480

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga 3540

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca 3600

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg 3660

taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcac 3720

tagaagcttt attgcggtag tttatcacag ttaaattgct aacgcagtca gtgcttctga 3780

cacaacagtc tcgaacttaa gctgcagaag ttggtcgtga ggcactgggc aggtaagtat 3840

caaggttaca agacaggttt aaggagacca atagaaactg ggcttgtcga gacagagaag 3900

actcttgcgt ttctgatagg cacctattgg tcttactgac atccactttg cctttctctc 3960

cacaggtgtc cactcccagt tcaattacag ctcttaaggc tagagtactc tagcccggga 4020

tccaccggtc gccaccatgt ttcaggatcc ccaggagcgg ggccgcaagc tgccacagct 4080

gtgcacagag ctccagacaa ccattcacga tattattctc gagtgcgtct actgtaagca 4140

gcagctcctg cgccgggagg tctacgactt cgctagacgc gacctgtgta tcgtctaccg 4200

cgatggaaat ccatacgccg tcggcgataa gtgcctcaag ttttactcta agatttctga 4260

gtaccggcac tactgttact cactgtacgg aaccaccctc gagcagcagt acaataagcc 4320

tctgtgtgat ctgctcatta gatgcattaa tggccagaag cctctctgtc cagaggagaa 4380

gcagcggcac ctcgataaga agcagcggtt tcacaatact aggggaaggt ggaccggaag 4440

gtgtatgtca tgttgtcggt catcaagaac tagacgcgag acacagctca gaaagaggcg 4500

cgggtcaggc gcaccagtca agcagactct gaactttgat ctcctcaagc tcgctggcga 4560

cgtcgagtct aatcctggcc cccacggcga caccccaacc ctccacgagt acatgctgga 4620

tctccagccc gagacaaccg acctctacgg gtacgggcag ctcaatgatt catcagagga 4680

ggaggatgag attgatggcc ccgccggaca ggctgagccc gatagggccc actacaatat 4740

cgtgacattt tgttgcaagg gcgattcaac actccgcctg tgcgtgcagt caacccacgt 4800

ggatattcgg actctcgagg atctgctcat gggaacactg ggaattgtgt gccctatttg 4860

ttcccagaag cctagaaaga ggcgcgggtc cggcgcaaca aattttagcc tgctcaagca 4920

ggctggcgac gtcgaggaga atcctgggcc cgctaggttt gaggatccaa ctagacgcgg 4980

gtacaagctc cccgatctgt gtacagagct gaatacatca ctccaggata ttgagattac 5040

ttgcgtgtac tgtaagaccg tcctcgagct gactgaggtc tttgagttcg ctagaaagga 5100

tctcttcgtg gtctaccggg attctatccc acacgccgcc ggacacaagt gcattgactt 5160

ttactctcgc attagggagc tcaggcacta ctccgatagc gtctacgggg atacactgga 5220

gaagctgact aatactggac tgtacaatct gctcattaga tgcctgcgcg gacagaagcc 5280

tctcaatccc gctgagaagc tgcggcacct gaatgagaag agacggtttc acaataccgc 5340

cggacactac cggggccagt gtcactcttg ttgtaatagg gctaggcagg agcggctcca 5400

gagacgccgc gagactcagg tccgcaagag gcgcgggtcc ggcgcacccg tgaagcagac 5460

cctgaacttt gatctcctga agctcgctgg ggacgtggag tctaaccctg ggccacacgg 5520

accaaaggct accctccagg atatcgtcct gcacctcgag ccacagaatg agattcccgt 5580

cgacctgctc ggccacggac agctgtccga tagcgaggag gagaacgatg agattgatgg 5640

ggtgaatcac cagcacctgc ccgctagacg cgccgagcca cagcggcaca ccatgctgtg 5700

tatgtgttgc aagggggagg cacgcatcga gctggtggtg gagtcttccg ccgatgacct 5760

cagggctttt cagcagctct ttctgaatac cctgtccttc gtgtgccctt ggtgcgcttc 5820

ccagcagtga agcggccgcc actgtgctgg atgatccgag ctcggtacct ctagagtcga 5880

cccgggcggc caaaccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt 5940

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc 6000

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt 6060

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat 6120

gcggtgggct ctatggcttc tgaggcggaa agaaccagca gatctgcaga tctgaattca 6180

tctatgtcgg gtgcggagaa agaggtaatg aaatggcatt atgggtatta tgggtctgca 6240

ttaatgaatc ggccagatat cgacatatgc tggccaccgt acatgtggct tcccatgctc 6300

gcaagccctg gcccgagttc gagcacaatg tcatgaccag gtgcaatatg catctggggt 6360

cccggcgatc gcccgaggca tgttcatgcc ctaccagtgc aacatgcaat ttgtgaaggt 6420

gctgctggag cccgatgcca tgtccagagt gagcctgacg ggggtgtttg acatgaatgt 6480

ggagctgtgg aaaattctga gatatgatga atccaagacc aggtgccggg cctgcgaatg 6540

cggaggcaag cacgccaggc ttcagcccgt gtgtgtggag gtgacggagg acctgcgacc 6600

cgatcatttg gtgttgtcct gcaacgggac ggagttcggc tccagcgggg aagaatctga 6660

ctagagtgag tagtgtttgg gggtgggtgg gagcctgcat gatgggcaga atgactaaaa 6720

tctgtgtttt tctgtgtgtt gcagcagcat gagcggaagc gcctcctttg agggaggggt 6780

attcagccct tatctgacgg ggcgtctccc ctcctgggcg ggagtgcgtc agaatgtgat 6840

gggatccacg gtggacggcc ggcccgtgca gcccgcgaac tcttcaaccc tgacctacgc 6900

gaccctgagc tcctcgtccg tggacgcagc tgccgccgca gctgctgctt ccgccgccag 6960

cgccgtgcgc ggaatggccc tgggcgccgg ctactacagc tctctggtgg ccaactcgag 7020

ttccaccaat aatcccgcca gcctgaacga ggagaagctg ttgctgctga tggcccagct 7080

cgaggccctg acccagcgcc tgggcgagct gacccagcag gtggctcagc tgcaggcgga 7140

gacgcgggcc gcggttgcca cggtgaaaac caaataaaaa atgaatcaat aaataaacgg 7200

agacggttgt tgattttaac acagagtctt gaatctttat ttgattttttc gcgcgcggta 7260

ggccctggac caccggtctc gatcattgag cacccggtgg atcttttcca ggacccggta 7320

gaggtgggct tggatgttga ggtacatggg catgagcccg tcccgggggt ggaggtagct 7380

ccattgcagg gcctcgtgct cgggggtggt gttgtaaatc acccagtcat agcaggggcg 7440

cagggcgtgg tgctgcacga tgtctttgag gaggagactg atggccacgg gcagcccctt 7500

ggtgtaggtg ttgacgaacc tattgagctg ggagggatgc atgcgggggg agatgagatg 7560

catcttggcc tggatcttga gattggcgat gttcccgccc agatcccgcc gggggttcat 7620

gttgtgcagg accaccagca cggtgtatcc ggtgcacttg gggaatttgt catgcaactt 7680

ggaagggaag gcgtgaaaga atttggagac gcccttgtga ccgcccaggt tttccatgca 7740

ctcatccatg atgatggcga tgggcccgtg ggcggcggcc tgggcaaaga cgtttcgggg 7800

gtcggacaca tcgtagttgt ggtcctgggt gagctcgtca taggccattt taatgaattt 7860

ggggcggagg gtacccgact gggggacaaa ggtgccctcg atcccggggg cgtagttccc 7920

ctcgcagatc tgcatctccc aggccttgag ctcggagggg gggatcatgt ccacctgcgg 7980

ggcgatgaaa aaaacggttt ccggggcggg ggagatgagc tgcgccgaaa gcaggttccg 8040

gagcagctgg gacttgccgc agccggtggg gccgtagatg accccgatga ccggctgcag 8100

gtggtagttg agggagagac agctgccgtc ctcgcggagg aggggggcca cctcgttcat 8160

catctcgcgc acatgcatgt tctcgcgcac gagttccgcc aggaggcgct cgccccccag 8220

cgagaggagc tcttgcagcg aggcgaagtt tttcagcggc ttgagcccgt cggccatggg 8280

cattttggag agggtctgtt gcaagagttc cagacggtcc cagagctcgg tgatgtgctc 8340

tagggcatct cgatccagca gacctcctcg tttcgcgggt tggggcgact gcgggagtag 8400

ggcaccaggc gatgggcgtc cagcgaggcc agggtccggt ccttccaggg tcgcagggtc 8460

cgcgtcagcg tggtctccgt cacggtgaag gggtgcgcgc cgggctgggc gcttgcgagg 8520

gtgcgcttca ggctcatccg gctggtcgag aaccgctccc ggtcggcgcc ctgcgcgtcg 8580

gccaggtagc aattgagcat gagttcgtag ttgagcgcct cggccgcgtg gcccttggcg 8640

cggagcttac ctttggaagt gtgtccgcag acgggacaga ggagggactt gagggcgtag 8700

agcttggggg cgaggaagac ggactcgggg gcgtaggcgt ccgcgccgca gctggcgcag 8760

acggtctcgc actccacgag ccaggtgagg tcggggcggt cggggtcaaa aacgaggttt 8820

cctccgtgct ttttgatgcg tttcttacct ctggtctcca tgagctcgtg tccccgctgg 8880

gtgacaaaga ggctgtccgt gtccccgtag accgacttta tgggccggtc ctcgagcggg 8940

gtgccgcggt cctcgtcgta gaggaacccc gcccactccg agacgaaggc ccgggtccag 9000

gccagcacga aggaggccac gtgggagggg tagcggtcgt tgtccaccag cgggtccacc 9060

ttctccaggg tatgcaagca catgtccccc tcgtccacat ccaggaaggt gattggcttg 9120

taagtgtagg ccacgtgacc gggggtcccg gccgggggggg tataaaaggg ggcgggcccc 9180

tgctcgtcct cactgtcttc cggatcgctg tccaggagcg ccagctgttg gggtaggtat 9240

tccctctcga aggcgggcat gacctcggca ctcaggttgt cagtttctag aaacgaggag 9300

gatttgatat tgacggtgcc gttggagacg cctttcatga gcccctcgtc catctggtca 9360

gaaaagacga tctttttgtt gtcgagcttg gtggcgaagg agccgtagag ggcgttggag 9420

agcagcttgg cgatggagcg catggtctgg ttcttttcct tgtcggcgcg ctccttggcg 9480

gcgatgttga gctgcacgta ctcgcgcgcc acgcacttcc attcggggaa gacggtggtg 9540

agctcgtcgg gcacgattct gacccgccag ccgcggttgt gcagggtgat gaggtccacg 9600

ctggtggcca cctcgccgcg caggggctcg ttggtccagc agaggcgccc gcccttgcgc 9660

gagcagaagg ggggcagcgg gtccagcatg agctcgtcgg gggggtcggc gtccacggtg 9720

aagatgccgg gcaggagctc ggggtcgaag tagctgatgc aggtgcccag atcgtccaga 9780

cttgcttgcc agtcgcgcac ggccagcgcg cgctcgtagg ggctgagggg cgtgccccag 9840

ggcatggggt gcgtgagcgc ggaggcgtac atgccgcaga tgtcgtagac gtagaggggc 9900

tcctggagga cgccgatgta ggtggggtag cagcgccccc cgcggatgct ggcgcgcacg 9960

tagtcgtaca gctcgtgcga gggcgcgagg agccccgtgc cgagattgga gcgctgcggc 10020

ttttcggcgc ggtagacgat ctggcggaag atggcgtggg agttggagga gatggtgggc 10080

ctctggaaga tgttgaagtg ggcatggggc agtccgaccg agtccctgat gaagtgggcg 10140

taggagtcct gcagcttggc gacgagctcg gcggtgacga ggacgtccag ggcgcagtag 10200

tcgagggtct cttggatgat gtcgtacttg agctggccct tctgcttcca cagctcgcgg 10260

ttgagaagga actcttcgcg gtccttccag tactcttcga gggggaaccc gtcctgatcg 10320

gcacggtaag agcccaccat gtagaactgg ttgacggcct tgtaggcgca gcagcccttc 10380

tccacgggga gggcgtaagc ttgcgcggcc ttgcgcaggg aggtgtgggt gagggcgaag 10440

gtgtcgcgca ccatgacttt gaggaactgg tgcttgaagt cgaggtcgtc gcagccgccc 10500

tgctcccaga gctggaagtc cgtgcgcttc ttgtaggcgg ggttgggcaa agcgaaagta 10560

acatcgttga agaggatctt gcccgcgcgg ggcatgaagt tgcgagtgat gcggaaaggc 10620

tggggcacct cggcccggtt gttgatgacc tgggcggcga ggacgatctc gtcgaagccg 10680

ttgatgttgt gcccgacgat gtagagttcc acgaatcgcg ggcggccctt gacgtggggc 10740

agcttcttga gctcgtcgta ggtgagctcg gcggggtcgc tgagcccgtg ctgctcgagg 10800

gcccagtcgg cgacgtgggg gttggcgctg aggaaggaag tccagagatc cacggccagg 10860

gcggtctgca agcggtcccg gtactgacgg aactgctggc ccacggccat tttttcgggg 10920

gtgacgcagt agaaggtgcg ggggtcgccg tgccagcggt cccacttgag ctggagggcg 10980

aggtcgtggg cgagctcgac gagcggcggg tccccggaga gtttcatgac cagcatgaag 11040

gggacgagct gcttgccgaa ggaccccatc caggtgtagg tttccacatc gtaggtgagg 11100

aagagccttt cggtgcgagg atgcgagccg atggggaaga actggatctc ctgccaccag 11160

ttggaggaat ggctgttgat gtgatggaag tagaaatgcc gacggcgcgc cgagcactcg 11220

tgcttgtgtt tatacaagcg tccgcagtgc tcgcaacgct gcacgggatg cacgtgctgc 11280

acgagctgta cctgggttcc tttgacgagg aatttcagtg ggcagtggag cgctggcggc 11340

tgcatctggt gctgtactac gtcctggcca tcggcgtggc catcgtctgc ctcgatggtg 11400

gtcatgctga cgagcccgcg cgggaggcag gtccagacct cggctcggac gggtcggaga 11460

gcgaggacga gggcgcgcag gccggagctg tccagggtcc tgagacgctg cggagtcagg 11520

tcagtgggca gcggcggcgc gcggttgact tgcaggagct tttccagggc gcgcgggagg 11580

tccagatggt acttgatctc cacggcgccg ttggtggcga cgtccacggc ttgcagggtc 11640

ccgtgcccct ggggcgccac caccgtgccc cgtttcttct tgggcggcgg cggctccatg 11700

cttagaagcg gcggcgagga cgcgcgccgg gcggcagggg cggctcgggg cccggaggca 11760

ggggcggcag gggcacgtcg gcgccgcgcg cgggcaggtt ctggtactgc gcccggagaa 11820

gactggcgtg agcgacgacg cgacggttga cgtcctggat ctgacgcctc tgggtgaagg 11880

ccacgggacc cgtgagtttg aacctgaaag agagttcgac agaatcaatc tcggtatcgt 11940

tgacggcggc ctgccgcagg atctcttgca cgtcgcccga gttgtcctgg taggcgatct 12000

cggtcatgaa ctgctcgatc tcctcctcct gaaggtctcc gcggccggcg cgctcgacgg 12060

tggccgcgag gtcgttggag atgcggccca tgagctgcga gaaggcgttc atgccggcct 12120

cgttccagac gcggctgtag accacggctc cgtcggggtc gcgcgcgcgc atgaccacct 12180

gggcgaggtt gagctcgacg tggcgcgtga agaccgcgta gttgcagagg cgctggtaga 12240

ggtagttgag cgtggtggcg atgtgctcgg tgacgaagaa gtacatgatc cagcggcgga 12300

gcggcatctc gctgacgtcg cccagggctt ccaagcgctc catggcctcg tagaagtcca 12360

cggcgaagtt gaaaaactgg gagttgcgcg ccgagacggt caactcctcc tccagaagac 12420

ggatgagctc ggcgatggtg gcgcgcacct cgcgctcgaa ggccccgggg ggctcctctt 12480

ccatttcctc ctcttcctcc tccactaaca tctcttctac ttcctcctca ggaggcggcg 12540

gcgggggagg ggccctgcgt cgccggcggc gcacgggcag acggtcgatg aagcgctcga 12600

tggtctcccc gcgccggcga cgcatggtct cggtgacggc gcgcccgtcc tcgcggggcc 12660

gcagcgtgaa gacgccgccg cgcatctcca ggtggccgcc gggggggtct ccgttgggca 12720

gggagagggc gctgacgatg catcttatca attgacccgt agggactccg cgcaaggacc 12780

tgagcgtctc gagatccacg ggatccgaaa accgctgaac gaaggcttcg agccagtcgc 12840

agtcgcaagg taggctgagc ccggtttctt gttcttcggg tatttggtcg ggaggcgggc 12900

gggcgatgct gctggtgatg aagttgaagt aggcggtcct gagacggcgg atggtggcga 12960

ggagcaccag gtccttgggc ccggcttgct ggatgcgcag acggtcggcc atgccccagg 13020

cgtggtcctg acacctggcg aggtccttgt agtagtcctg catgagccgc tccacgggca 13080

cctcctcctc gcccgcgcgg ccgtgcatgc gcgtgagccc gaacccgcgc tgcggctgga 13140

cgagcgccag gtcggcgacg acgcgctcgg cgaggatggc ctgctggatc tgggtgaggg 13200

tggtctggaa gtcgtcgaag tcgacgaagc ggtggtaggc tccggtgttg atggtgtagg 13260

agcagttggc catgacggac cagttgacgg tctggtggcc ggggcgcacg agctcgtggt 13320

acttgaggcg cgagtaggcg cgcgtgtcga agatgtagtc gttgcaggtg cgcacgaggt 13380

actggtatcc gacgaggaag tgcggcggcg gctggcggta gagcggccat cgctcggtgg 13440

cgggggcgcc gggcgcgagg tcctcgagca tgaggcggtg gtagccgtag atgtacctgg 13500

acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg gaactcgcgg acgcggttcc 13560

agatgttgcg cagcggcagg aagtagttca tggtggccgc ggtctggccc gtgaggcgcg 13620

cgcagtcgtg gatgctctag acatacgggc aaaaacgaaa gcggtcagcg gctcgactcc 13680

gtggcctgga ggctaagcga acgggttggg ctgcgcgtgt accccggttc gaatctcgaa 13740

tcaggctgga gccgcagcta acgtggtact ggcactcccg tctcgaccca agcctgctaa 13800

cgaaacctcc aggatacgga ggcgggtcgt tttttggcct tggtcgctgg tcatgaaaaa 13860

ctagtaagcg cggaaagcgg ccgcccgcga tggctcgctg ccgtagtctg gagaaagaat 13920

cgccagggtt gcgttgcggt gtgccccggt tcgagcctca gcgctcggcg ccggccggat 13980

tccgcggcta acgtgggcgt ggctgccccg tcgtttccaa gaccccttag ccagccgact 14040

tctccagtta cggagcgagc ccctcttttt ttcttgtgtt tttgccagat gcatcccgta 14100

ctgcggcaga tgcgccccca ccctccacca caaccgcccc taccgcagca gcagcaacag 14160

ccggcgcttc tgcccccgcc ccagcagcag cagccagcca ctaccgcggc ggccgccgtg 14220

agcggagccg gcgttcagta tgacctggcc ttggaagagg gcgaggggct ggcgcggctg 14280

ggggcgtcgt cgccggagcg gcacccgcgc gtgcagatga aaagggacgc tcgcgaggcc 14340

tacgtgccca agcagaacct gttcagagac aggagcggcg aggagcccga ggagatgcgc 14400

gcctcccgct tccacgcggg gcgggagctg cggcgcggcc tggaccgaaa gcgggtgctg 14460

agggacgagg atttcgaggc ggacgagctg acggggatca gccccgcgcg cgcgcacgtg 14520

gccgcggcca acctggtcac ggcgtacgag cagaccgtga aggaggagag caacttccaa 14580

aaatccttca acaaccacgt gcgcacgctg atcgcgcgcg aggaggtgac cctgggcctg 14640

atgcacctgt gggacctgct ggaggccatc gtgcagaacc ccacgagcaa gccgctgacg 14700

gcgcagctgt ttctggtggt gcagcacagt cgggacaacg agacgttcag ggaggcgctg 14760

ctgaatatca ccgagcccga gggccgctgg ctcctggacc tggtgaacat tctgcagagc 14820

atcgtggtgc aggagcgcgg gctgccgctg tccgagaagc tggcggccat caacttctcg 14880

gtgctgagcc tgggcaagta ctacgctagg aagatctaca agaccccgta cgtgcccata 14940

gacaaggagg tgaagatcga tgggttttac atgcgcatga ccctgaaagt gctgaccctg 15000

agcgacgatc tgggggtgta ccgcaacgac aggatgcacc gcgcggtgag cgccagccgc 15060

cggcgcgagc tgagcgacca ggagctgatg cacagcctgc agcgggccct gaccggggcc 15120

gggaccgagg gggagagcta ctttgacatg ggcgcggacc tgcgctggca gcccagccgc 15180

cgggccttgg aagctgccgg cggcgtgccc tacgtggagg aggtggacga tgaggaggag 15240

gagggcgagt acctggaaga ctgatggcgc gaccgtattt ttgctagatg cagcaacagc 15300

caccgccgcc gcctcctgat cccgcgatgc gggcggcgct gcagagccag ccgtccggca 15360

ttaactcctc ggacgattgg acccaggcca tgcaacgcat catggcgctg acgacccgca 15420

atcccgaagc ctttagacag cagcctcagg ccaaccggct ctcggccatc ctggaggccg 15480

tggtgccctc gcgctcgaac cccacgcacg agaaggtgct ggccatcgtg aacgcgctgg 15540

tggagaacaa ggccatccgc ggcgacgagg ccgggctggt gtacaacgcg ctgctggagc 15600

gcgtggcccg ctacaacagc accaacgtgc agacgaacct ggaccgcatg gtgaccgacg 15660

tgcgcgaggc ggtgtcgcag cgcgagcggt tccaccgcga gtcgaacctg ggctccatgg 15720

tggcgctgaa cgccttcctg agcacgcagc ccgccaacgt gccccggggc caggaggact 15780

acaccaactt catcagcgcg ctgcggctga tggtggccga ggtgccccag agcgaggtgt 15840

accagtcggg gccggactac ttcttccaga ccagtcgcca gggcttgcag accgtgaacc 15900

tgagccaggc tttcaagaac ttgcagggac tgtggggcgt gcaggccccg gtcggggacc 15960

gcgcgacggt gtcgagcctg ctgacgccga actcgcgcct gctgctgctg ctggtggcgc 16020

ccttcacgga cagcggcagc gtgagccgcg actcgtacct gggctacctg cttaacctgt 16080

accgcgaggc catcgggcag gcgcacgtgg acgagcagac ctaccaggag atcacccacg 16140

tgagccgcgc gctgggccag gaggacccgg gcaacctgga ggccaccctg aacttcctgc 16200

tgaccaaccg gtcgcagaag atcccgcccc agtacgcgct gagcaccgag gaggagcgca 16260

tcctgcgcta cgtgcagcag agcgtggggc tgttcttgat gcaggagggg gccacgccca 16320

gcgccgcgct cgacatgacc gcgcgcaaca tggagcccag catgtacgcc cgcaaccgcc 16380

cgttcatcaa taagctgatg gactacttgc atcgggcggc cgccatgaac tcggactact 16440

ttaccaacgc catcttgaac ccgcactggc tcccgccgcc cgggttctac acgggcgagt 16500

acgacatgcc cgaccccaac gacgggttcc tgtgggacga cgtggacagc agcgtgttct 16560

cgccgcggcc caccaccacc accgtgtgga agaaagaggg cggggaccgg cggccgtcct 16620

cggcgctgtc cggtcgcgcg ggtgctgccg cggcggtgcc cgaggctgcc agccccttcc 16680

cgagcctgcc cttttcgctg aacagcgtgc gcagcagcga gctgggtcgg ctgacgcggc 16740

cgcgcctgct gggcgaggag gagtacctga acgactcctt gttgaagccc gagcgcgaga 16800

agaacttccc caataacggg atagagagcc tggtggacaa gatgagccgc tggaagacgt 16860

acgcgcacga gcacagggac gagccccgag ctagcagcgc aggcacccgt agacgccagc 16920

ggcacgacag gcagcgggga ctggtgtggg acgatgagga ttccgccgac gacagcagcg 16980

tgttggactt gggtgggagt ggtggtggta acccgttcgc tcacctgcgc ccccgtatcg 17040

ggcgcctgat gtaagaatct gaaaaaataa aagacggtac tcaccaaggc catggcgacc 17100

agcgtgcgtt cttctctgtt gtttgtagta gtatgatgag gcgcgtgtac ccggagggtc 17160

ctcctccctc gtacgagagc gtgatgcagc aggcggtggc ggcggcgatg cagcccccgc 17220

tggaggcgcc ttacgtgccc ccgcggtacc tggcgcctac ggaggggcgg aacagcattc 17280

gttactcgga gctggcaccc ttgtacgata ccacccggtt gtacctggtg gacaacaagt 17340

cggcggacat cgcctcgctg aactaccaga acgaccacag caacttcctg accaccgtgg 17400

tgcagaacaa cgatttcacc cccacggagg ccagcaccca gaccatcaac tttgacgagc 17460

gctcgcggtg gggcggccag ctgaaaacca tcatgcacac caacatgccc aacgtgaacg 17520

agttcatgta cagcaacaag ttcaaggcgc gggtgatggt ctcgcgcaag acccccaacg 17580

gggtcacggt aggggatgat tatgatggta gtcaggacga gctgacctac gagtgggtgg 17640

agtttgagct gcccgagggc aacttctcgg tgaccatgac catcgatctg atgaacaacg 17700

ccatcatcga caactacttg gcggtggggc ggcagaacgg ggtgctggag agcgacatcg 17760

gcgtgaagtt cgacacgcgc aacttccggc tgggctggga ccccgtgacc gagctggtga 17820

tgccgggcgt gtacaccaac gaggccttcc accccgacat cgtcctgctg cccggctgcg 17880

gcgtggactt caccgagagc cgcctcagca acctgctggg catccgcaag cggcagccct 17940

tccaggaggg cttccagatc ctgtacgagg acctggaggg gggcaacatc cccgcgctct 18000

tggatgtcga agcctatgaa gaaagtaagg aaaaagcaga ggctgaggca actacagccg 18060

tggctaccgc cgcgactgtg gcagatgcca ctgtcaccag gggcgataca ttcgccaccc 18120

aggcggagga agcagccgcc ctagcggcga ccgatgatag tgaaagtaag atagtcatca 18180

agccggtgga gaaggacagc aagaacagga gctacaacgt tctaccggat ggaaagaaca 18240

ccgcctaccg cagctggtac ctggcctaca actacggcga ccccgagaag ggcgtgcgct 18300

cctggacgct gctcaccacc tcggacgtca cctgcggcgt ggagcaagtc tactggtcgc 18360

tgcccgacat gatgcaagac ccggtcacct tccgctccac gcgacaagtt agcaactacc 18420

cggtggtggg cgccgagctc ctgcccgtct actccaagag cttcttcaac gagcaggccg 18480

tctactcgca gcagctgcgt gccttcacct cgctcacgca cgtcttcaac cgcttccccg 18540

agaaccagat cctcgtccgc ccgcccgcgc ccaccattac caccgtcagt gaaaacgttc 18600

ctgctctcac agatcacggg accctgccgc tgcgcagcag tatccgggga gtccagcgcg 18660

tgaccgtcac tgacgccaga cgccgcacct gcccctacgt ctacaaggcc ctgggcgtag 18720

tcgcgccgcg cgtcctctcg agccgcacct tctaaaaaat gtccattctc atctcgccca 18780

gtaataacac cggttggggc ctgcgcgcgc ccagcaagat gtacggaggc gctcgccaac 18840

gctccacgca acaccccgtg cgcgtgcgcg ggcacttccg cgctccctgg ggcgccctca 18900

agggccgcgt gcgctcgcgc accaccgtcg acgacgtgat cgaccaggtg gtggccgacg 18960

cgcgcaacta cacgcccgcc gccgcgcccg cctccaccgt ggacgccgtc atcgacagcg 19020

tggtggccga cgcgcgccgg tacgcccgcg ccaagagccg gcggcggcgc atcgcccggc 19080

ggcaccggag cacccccgcc atgcgcgcgg cgcgagcctt gctgcgcagg gccaggcgca 19140

cgggacgcag ggccatgctc agggcggcca gacgcgcggc ctccggcagc agcagcgccg 19200

gcaggacccg cagacgcgcg gccacggcgg cggcggcggc catcgccagc atgtcccgcc 19260

cgcggcgcgg caacgtgtac tgggtgcgcg acgccgccac cggtgtgcgc gtgcccgtgc 19320

gcacccgccc ccctcgcact tgaagatgct gacttcgcga tgttgatgtg tcccagcggc 19380

gaggaggatg tccaagcgca aatacaagga agagatgctc caggtcatcg cgcctgagat 19440

ctacggcccc gcggcggcgg tgaaggagga aagaaagccc cgcaaactga agcgggtcaa 19500

aaaggacaaa aaggaggagg aagatgacgg actggtggag tttgtgcgcg agttcgcccc 19560

ccggcggcgc gtgcagtggc gcgggcggaa agtgaaaccg gtgctgcggc ccggcaccac 19620

ggtggtcttc acgcccggcg agcgttccgg ctccgcctcc aagcgctcct acgacgaggt 19680

gtacggggac gaggacatcc tcgagcaggc ggtcgagcgt ctgggcgagt ttgcttacgg 19740

caagcgcagc cgccccgcgc ccttgaaaga ggaggcggtg tccatcccgc tggaccacgg 19800

caaccccacg ccgagcctga agccggtgac cctgcagcag gtgctgccga gcgcggcgcc 19860

gcgccggggc ttcaagcgcg agggcggcga ggatctgtac ccgaccatgc agctgatggt 19920

gcccaagcgc cagaagctgg aggacgtgct ggagcacatg aaggtggacc ccgaggtgca 19980

gcccgaggtc aaggtgcggc ccatcaagca ggtggccccg ggcctgggcg tgcagaccgt 20040

ggacatcaag atccccacgg agcccatgga aacgcagacc gagcccgtga agcccagcac 20100

cagcaccatg gaggtgcaga cggatccctg gatgccagcg gcttccacca ccaccactcg 20160

ccgaagacgc aagtacggcg cggccagcct gctgatgccc aactacgcgc tgcatccttc 20220

catcatcccc acgccgggct accgcggcac gcgcttctac cgcggctaca ccagcagccg 20280

ccgccgcaag accaccaccc gccgccgtcg tcgcagccgc cgcagcagca ccgcgacttc 20340

cgccttggtg cggagagtgt atcgcagcgg gcgcgagcct ctgaccctgc cgcgcgcgcg 20400

ctaccacccg agcatcgcca tttaactacc gcctcctact tgcagatatg gccctcacat 20460

gccgcctccg cgtccccatt acgggctacc gaggaagaaa gccgcgccgt agaaggctga 20520

cggggaacgg gctgcgtcgc catcaccacc ggcggcggcg cgccatcagc aagcggttgg 20580

ggggaggctt cctgcccgcg ctgatcccca tcatcgccgc ggcgatcggg gcgatccccg 20640

gcatagcttc cgtggcggtg caggcctctc agcgccactg agaacacaaaa aagcatggat 20700

ttgtaataaa aaaatggact gacgctcctg gtcctgtgat gtgtgttttt agatggaaga 20760

catcaatttt tcgtccctgg caccgcgaca cggcacgcgg ccgtttatgg gcacctggag 20820

cgacatcggc aacagccaac tgaacggggg cgccttcaat tggagcagtc tctggagcgg 20880

gcttaagaat ttcgggtcca cgctcaaaac ctatggcaac aaggcgtgga acagcagcac 20940

agggcaggcg ctgagggaaa agctgaaaga gcagaacttc cagcagaagg tggtcgatgg 21000

cctggcctcg ggcatcaacg gggtggtgga cctggccaac caggccgtgc agaaacagat 21060

caacagccgc ctggacgcgg tcccgcccgc ggggtccgtg gagatgcccc aggtggagga 21120

ggagctgcct cccctggaca agcgcggcga caagcgaccg cgtcccgacg cggaggac 21180

gctgctgacg cacacggacg agccgccccc gtacgaggag gcggtgaaac tgggtctgcc 21240

caccacgcgg cccgtggcgc ctctggccac cggggtgctg aaacccagca gcagcagcca 21300

gcccgcgacc ctggacttgc ctccgcctgc ttcccgcccc tccacagtgg ctaagcccct 21360

gccgccggtg gccgtcgcgt cgcgcgcccc ccgaggccgc ccccaggcga actggcagag 21420

cactctgaac agcatcgtgg gtctgggagt gcagagtgtg aagcgccgcc gctgctatta 21480

aaagacactg tagcgcttaa cttgcttgtc tgtgtgtgta tatgtatgtc cgccgaccag 21540

aaggaggaag aggcgcgtcg ccgagttgca agatggccac cccatcgatg ctgccccagt 21600

gggcgtacat gcacatcgcc ggacaggacg cttcggagta cctgagtccg ggtctggtgc 21660

agttcgcccg cgccacagac acctacttca gtctggggaa caagtttagg aaccccacgg 21720

tggcgcccac gcacgatgtg accaccgacc gcagccagcg gctgacgctg cgcttcgtgc 21780

ccgtggaccg cgaggacaac acctactcgt acaaagtgcg ctacacgctg gccgtgggcg 21840

acaaccgcgt gctggacatg gccagcacct actttgacat ccgcggcgtg ctggatcggg 21900

gccccagctt caaaccctac tccggcaccg cctacaacag cctagctccc aagggagcgc 21960

ccaacacctc acagtggaag gattccgaca gcaaaatgca tacttttgga gttgctgcca 22020

tgcccggtgt tgttggtaaa aaaatagaag ccgatggtct gcctattgga atagattcat 22080

cctctggaac tgacaccata atttatgctg ataaaacttt ccaaccagag ccacaggttg 22140

gaagtgacag ttgggtcgac accaatggtg cagaggaaaa atatggaggt agagctctta 22200

aggacactac aaacatgaag ccctgctacg gttcttttgc caggcctacc aacaaagaag 22260

gtggacaggc taacataaaa gattctgaaa ctgccagcac tactcctaac tatgatatag 22320

atttggcatt ctttgacagc aaaaatattg cagctaacta cgatccagat attgtaatgt 22380

acacagaaaa tgttgagttg caaactccag atactcatat tgtgtttaag ccaggaactt 22440

cagatgaaag ttcagaagcc aatttgggcc agcaggccat gcccaacaga cccaactaca 22500

tcgggttcag agacaacttt atcgggctca tgtactacaa cagcactggc aatatgggtg 22560

tactggctgg tcaggcctcc cagctaaatg ctgtggtgga cttgcaggac agaaacaccg 22620

aactgtccta ccagctcttg cttgactctc tgggtgacag aaccaggtat ttcagtatgt 22680

ggaatcaggc ggtggacagc tatgaccccg atgtgcgcat tattgaaaat cacggtgtgg 22740

aggatgaact ccccaattat tgcttccctt tgaatggtgt aggctttaca gatacttacc 22800

agggtgttaa agttaagaca gatacagccg ctactggtac caatggaacg cagtgggaca 22860

aagatgatac cacagtcagc actgccaatg agatccactc aggcaatcct ttcgccatgg 22920

agatcaacat ccaggccaac ctgtggcgga acttcctcta cgcgaacgtg gcgctgtacc 22980

tgcccgactc ctacaagtac acgccggcca acatcacgct gccgaccaac accaacacct 23040

acgattacat gaacggccgc gtggtggcgc cctcgctggt ggacgcctac atcaacatcg 23100

gggcgcgctg gtcgctggac cccatggaca acgtcaaccc cttcaaccac caccgcaacg 23160

cgggcctgcg ctaccgctcc atgctcctgg gcaacgggcg ctacgtgccc ttccacatcc 23220

aggtgcccca aaagttttttc gccatcaaga gcctcctgct cctgcccggg tcctacacct 23280

acgagtggaa cttccgcaag gacgtcaaca tgatcctgca gagctccctc ggcaacgacc 23340

tgcgcacgga cggggcctcc atcgccttca ccagcatcaa cctctacgcc accttcttcc 23400

ccatggcgca caacaccgcc tccacgctcg aggccatgct gcgcaacgac accaacgacc 23460

agtccttcaa cgactacctc tcggcggcca acatgctcta ccccatcccg gccaacgcca 23520

ccaacgtgcc catctccatc ccctcgcgca actgggccgc cttccgcgga tggtccttca 23580

cgcgcctcaa gacccgcgag acgccctcgc tcggctccgg gttcgacccc tacttcgtct 23640

actcgggctc catcccctac ctcgacggca ccttctacct caaccacacc ttcaagaagg 23700

tctccatcac cttcgactcc tccgtcagct ggcccggcaa cgaccgcctc ctgacgccca 23760

acgagttcga aatcaagcgc accgtcgacg gagagggata caacgtggcc cagtgcaaca 23820

tgaccaagga ctggttcctg gtccagatgc tggcccacta caacatcggc taccagggct 23880

tctacgtgcc cgagggctac aaggaccgca tgtactcctt cttccgcaac ttccagccca 23940

tgagccgcca ggtcgtggac gaggtcaact acaaggacta ccaggccgtc accctggcct 24000

accagcacaa caactcgggc ttcgtcggct acctcgcgcc caccatgcgc cagggccagc 24060

cctaccccgc caactacccc tacccgctca tcggcaagag cgccgtcgcc agcgtcaccc 24120

agaaaaagtt cctctgcgac cgggtcatgt ggcgcatccc cttctccagc aacttcatgt 24180

ccatgggcgc gctcaccgac ctcggccaga acatgctcta cgccaactcc gcccacgcgc 24240

tagacatgaa tttcgaagtc gaccccatgg atgagtccac ccttctctat gttgtcttcg 24300

aagtcttcga cgtcgtccga gtgcaccagc cccaccgcgg cgtcatcgag gccgtctacc 24360

tgcgcacgcc cttctcggcc ggcaacgcca ccacctaaag ccccgctctt gcttcttgca 24420

agatgacggc ctgtggctcc ggcgagcagg agctcagggc catcctccgc gacctgggct 24480

gcgggccctg cttcctgggc accttcgaca agcgcttccc gggattcatg gccccgcaca 24540

agctggcctg cgccatcgtc aacacggccg gccgcgagac cgggggcgag cactggctgg 24600

ccttcgcctg gaacccgcgc tcccacacct gctacctctt cgaccccttc gggttctcgg 24660

acgagcgcct caagcagatc taccagttcg agtacgaggg cctgctgcgc cgcagcgccc 24720

tggccaccga ggaccgctgc atcaccctgg aaaagtccac ccagaccgtg cagggtccgc 24780

gctcggccgc ctgcgggctc ttctgctgca tgttcctgca cgccttcgtg cactggcccg 24840

accgccccat ggacaagaac cccaccatga acttgctgac gggggtgccc aacggcatgc 24900

tccagtcgcc ccaggtggaa cccaccctgc gccgcaacca ggaggcgctc taccgcttcc 24960

tcaacgccca ctccgcctac tttcgctccc accgcgcgcg catcgagaag gccaccgcct 25020

tcgaccgcat gaatcaagac atgtaaactg tgtgtatgtg aatgctttat tcatcataat 25080

aaacagcaca tgtttatgcc accttctctg aggctctgac tttatttaga aatcgaaggg 25140

gttctgccgg ctctcggcgt gccccgcggg cagggatacg ttgcggaact ggtacttggg 25200

cagccacttg aactcgggga tcagcagctt cggcacgggg aggtcgggga acgagtcgct 25260

ccacagcttg cgcgtgagtt gcagggcgcc cagcaggtcg ggcgcggaga tcttgaaatc 25320

gcagttggga cccgcgttct gcgcgcgaga gttgcggtac acggggttgc agcactggaa 25380

caccatcagg gccgggtgct tcacgctcgc cagcaccgtc gcgtcggtga tgccctccac 25440

gtccagatcc tcggcgttgg ccatcccgaa gggggtcatc ttgcaggtct gccgccccat 25500

gctgggcacg cagccgggct tgtggttgca atcgcagtgc agggggatca gcatcatctg 25560

agcctgctcg gagctcatgc ccgggtacat ggccttcatg aaagcctcca gctggcggaa 25620

ggcctgctgc gccttgccgc cctcggtgaa gaagacccca caggacttgc tagagaactg 25680

gttggtggcg cagcccgcgt cgtgcacgca gcagcgcgcg tcgttgttgg ccagctgcac 25740

cacgctgcgc ccccagcggt tctgggtgat cttggcccgg tcggggttct ccttcagcgc 25800

gcgctgcccg ttctcgctcg ccacatccat ctcgatcgtg tgctccttct ggatcatcac 25860

ggtcccgtgc aggcaccgca gcttgccctc ggcctcggtg cacccgtgca gccacagcgc 25920

gcagccggtg cactcccagt tcttgtgggc gatctgggag tgcgagtgca cgaagccctg 25980

caggaagcgg cccatcatcg tggtcagggt cttgttgctg gtgaaggtca gcgggatgcc 26040

gcggtgctcc tcgttcacat acaggtggca gatgcggcgg tacacctcgc cctgctcggg 26100

catcagctgg aaggcggact tcaggtcgct ctccacgcgg taccgctcca tcagcagcgt 26160

catcacttcc atgcccttct cccaggccga aacgatcggc aggctcaggg ggttcttcac 26220

cgtcatctta gtcgccgccg ccgaagtcag ggggtcgttc tcgtccaggg tctcaaacac 26280

tcgcttgccg tccttctcgg tgatgcgcac ggggggaaag ctgaagccca cggccgccag 26340

ctcctcctcg gcctgccttt cgtcctcgct gtcctggctg atgtcttgca aaggcacatg 26400

cttggtcttg cggggtttct ttttgggcgg cagaggcggc ggcggagacg tgctgggcga 26460

gcgcgagttc tcgctcacca cgactatttc ttcttcttgg ccgtcgtccg agaccacgcg 26520

gcggtaggca tgcctcttct ggggcagagg cggaggcgac gggctctcgc ggttcggcgg 26580

gcggctggca gagccccttc cgcgttcggg ggtgcgctcc tggcggcgct gctctgactg 26640

acttcctccg cggccggcca ttgtgttctc ctagggagca acaagcatgg agactcagcc 26700

atcgtcgcca acatcgccat ctgcccccgc cgccgacgag aaccagcagc agcagaatga 26760

aagcttaacc gccccgccgc ccagccccac ctccgacgcc gccgcggccc cagacatgca 26820

agagatggag gaatccatcg agattgacct gggctacgtg acgcccgcgg agcacgagga 26880

ggagctggca gcgcgctttt cagccccgga agagaaccac caagagcagc cagagcagga 26940

agcagagagc gagcagcagc aggctgggct cgagcatggc gactacctga gcggggcaga 27000

ggacgtgctc atcaagcatc tggcccgcca aagcatcatc gtcaaggacg cgctgctcga 27060

ccgcgccgag gtgcccctca gcgtggcgga gctcagccgc gcctacgagc gcaacctctt 27120

ctcgccgcgc gtgcccccca agcgccagcc caacggcacc tgcgagccca acccgcgcct 27180

caacttctac ccggtcttcg cggtgcccga ggccctggcc acctaccacc tctttttcaa 27240

gaaccaaagg atccccgtct cctgccgcgc caaccgcacc cgcgccgacg ccctgctcaa 27300

cctgggtccc ggcgcccgcc tacctgatat cacctccttg gaagaggttc ccaagatctt 27360

cgagggtctg ggcagcgacg agactcgggc cgcgaacgct ctgcaaggaa gcggagagga 27420

gcatgagcac cacagcgccc tggtggagtt ggaaggcgac aacgcgcgcc tggcggtgct 27480

caagcgcacg gtcgagctga cccacttcgc ctacccggcg ctcaacctgc cccccaaggt 27540

catgagcgcc gtcatggacc aggtgctcat caagcgcgcc tcgcccctct cagaggagga 27600

gatgcaggac cccgagagct cggacgaggg caagcccgtg gtcagcgacg agcagctggc 27660

gcgctggctg ggagcgagca gcacccccca gagcctggaa gagcggcgca agctcatgat 27720

ggccgtggtc ctggtgaccg tggagctgga gtgtctgcgc cgcttcttcg ccgacgcgga 27780

gaccctgcgc aaggtcgagg agaacctgca ctacctcttc aggcacgggt tcgtgcgcca 27840

ggcctgcaag atctccaacg tggagctgac caacctggtc tcctacatgg gcatcctgca 27900

cgagaaccgc ctggggcaga acgtgctgca caccaccctg cgcggggagg cccgccgcga 27960

ctacatccgc gactgcgtct acctgtacct ctgccacacc tggcagacgg gcatgggcgt 28020

gtggcagcag tgcctggagg agcagaacct gaaagagctc tgcaagctcc tgcagaagaa 28080

cctcaaggcc ctgtggaccg ggttcgacga gcgcaccacc gcctcggacc tggccgacct 28140

catcttcccc gagcgcctgc ggctgacgct gcgcaacggg ctgcccgact ttatgagcca 28200

aagcatgttg caaaactttc gctctttcat cctcgaacgc tccgggatcc tgcccgccac 28260

ctgctccgca ctgccctcgg acttcgtgcc gctgaccttc cgcgagtgcc ccccgccgct 28320

ctggagccac tgctacttgc tgcgcctggc caactacctg gcctaccact cggacgtgat 28380

cgaggacgtc agcagcgagg gtctgctcga gtgccactgc cgctgcaacc tctgcacgcc 28440

gcaccgctcc ttggcctgca acccccagct gctgagcgag acccagatca tcggcacctt 28500

cgagttgcaa ggccccggcg agggcaaggg gggtctcaaa ctcaccccgg ggctgtggac 28560

ctcggcctac ttgcgcaagt tcgtgcccga ggactaccat cccttcgaga tcaggttcta 28620

cgaggaccaa tcccagccgc ccaaggccga gctgtcggcc tgcgtcatca cccaggggggc 28680

catcctggcc caattgcaag ccatccagaa atcccgccaa gaatttctgc tgaaaaaggg 28740

ccacggggtc tacttggacc cccagaccgg agaggagctc aaccccagct tcccccagga 28800

tgccccgagg aagcagcaag aagctgaaag tggagctgcc gctgccgccg gaggatttgg 28860

aggaagactg ggagagcagt caggcagagg agatggaaga ctgggacagc actcaggcag 28920

aggaggacag cctgcaagac agtctggagg aggaagacga ggtggaggag gaggcagagg 28980

aagaagcagc cgccgccaga ccgtcgtcct cggcggagga gaaagcaagc agcacggata 29040

ccatctccgc tccgggtcgg ggtcgcggcg gccgggccca cagtagatgg gacgagaccg 29100

ggcgcttccc gaaccccacc acccagaccg gtaagaagga gcggcaggga tacaagtcct 29160

ggcgggggca caaaaacgcc atcgtctcct gcttgcaagc ctgcgggggc aacatctcct 29220

tcacccggcg ctacctgctc ttccaccgcg gggtgaactt cccccgcaac atcttgcatt 29280

actaccgtca cctccacagc ccctactact gtttccaaga agaggcagaa acccagcagc 29340

agcagcagaa aaccagcggc agcagcagca gctagaaaat ccacagcggc ggcaggtgga 29400

ctgaggatcg cggcgaacga gccggcgcag acccgggagc tgaggaaccg gatctttccc 29460

accctctatg ccatcttcca gcagagtcgg gggcaggagc aggaactgaa agtcaagaac 29520

cgttctctgc gctcgctcac ccgcagttgt ctgtatcaca agagcgaaga ccaacttcag 29580

cgcactctcg aggacgccga ggctctcttc aacaagtact gcgcgctcac tcttaaagag 29640

tagcccgcgc ccgcccacac acggaaaaag gcgggaatta cgtcaccacc tgcgcccttc 29700

gcccgaccat catcatgagc aaagagattc ccacgcctta catgtggagc taccagcccc 29760

agatgggcct ggccgccggc gccgcccagg actactccac ccgcatgaac tggctcagtg 29820

ccgggcccgc gatgatctca cgggtgaatg acatccgcgc ccaccgaaac cagatactcc 29880

tagaacagtc agcgatcacc gccacgcccc gccatcacct taatccgcgt aattggcccg 29940

ccgccctggt gtaccaggaa attccccagc ccacgaccgt actacttccg cgagacgccc 30000

aggccgaagt ccagctgact aactcaggtg tccagctggc cggcggcgcc gccctgtgtc 30060

gtcaccgccc cgctcagggt ataaagcggc tggtgatccg aggcagaggc acacagctca 30120

acgacgaggt ggtgagctct tcgctgggtc tgcgacctga cggagtcttc caactcgccg 30180

gatcggggag atcttccttc acgcctcgtc aggccgtcct gactttggag agttcgtcct 30240

cgcagccccg ctcgggcggc atcggcactc tccagttcgt ggaggaggttc actccctcgg 30300

tctacttcaa ccccttctcc ggctcccccg gccactaccc ggacgagttc atcccgaact 30360

tcgacgccat cagcgagtcg gtggacggct acgattgaat gtcccatggt ggcgcggctg 30420

acctagctcg gcttcgacac ctggaccact gccgccgctt ccgctgcttc gctcgggatc 30480

tcgccgagtt tgcctacttt gagctgcccg aggagcaccc tcagggcccg gcccacggag 30540

tgcggatcgt cgtcgaaggg ggcctcgact cccacctgct tcggattttc agccagcgtc 30600

cgatcctggt cgagcgcgag caaggacaga cccttctgac cctgtactgc atctgcaacc 30660

accccggcct gcatgaaagt ctttgttgtc tgctgtgtac tgagtataat aaaagctgag 30720

atcagcgact actccggact cgattgtggt gttcctgcta tcaaccggtc cctgttcttc 30780

accgggaacg agaccgagct ccagctccag tgtaagcccc acaagaagta tctcacctgg 30840

ctgttccagg gctctccgat cgccgttgtc aaccactgcg acaacgacgg agtcctgctg 30900

agcggccctg ccaaccttac tttttccacc cgcagaagca agctccagct cttccaaccc 30960

ttcctccccg ggacctatca gtgcgtctcg ggaccctgcc atcacacctt ccacctgatc 31020

ccgaatacca cagcgccgct ccccgctact aacaaccaaa ctacccacca acgccaccgt 31080

cgcgaccttt ctgaatctaa tactaccacc cacaccggag gtgagctccg aggtcgacca 31140

acctctggga tttactacgg ggttaaccac gtggttacta tgtccttccg agtgagagac 31200

acaaaaaatt ccaacacact attgcaatga aaataaattt cctttattag ccagaagtca 31260

gatgctcaag gggcttcatg atgtccccat aatttttggc agagggaaaa agatctccat 31320

ggcctaggtc tagattactt ctgaccgggc tttttgcact cgaaggggat gtcggttaaa 31380

aaggtcttta aagagtcgat gaagtcggcg taggtggtaa cttgggtctc gcaatctgtc 31440

tcgggggtgg gggggcagta ggtctggtag tagctggcgg tcatgtttaa agcgcccttc 31500

agcttggtga agttgcccct cagaccttgc tcgaagatct tcagacgagt ctgcacacaa 31560

gtcagcttct tgaagctgaa ctcgttgctc accacctcga cctcctcatt taaagtcacg 31620

ggcatgtcgt ccagtaaatt taaagcttcc ttgatggcct ccacgtgctt ccaaggacga 31680

gtcactgtga taggggaacg agtgggggcg cttaaagagt acaccacgat gcctaaaaac 31740

agtaaattct gcagccacat ggtcctaggc tgttcgtcac ccaggacctg gctagcctgc 31800

ccagtgcctc acgaccaact tctgcagctt aagttcgaga ctgttgtgtc agaagcactg 31860

actgcgttag caatttaact gtgataaact accgcaataa agcttgctcc cgcccgccgc 31920

gcgcttcgct ttttataggg ccgccgccgc cgccgcctcg ccataaaagg aaactttcgg 31980

agcgcgccgc tctgattggc tgccgccgca cctctccgcc tcgccccgcc ccgcccctcg 32040

ccccgccccg ccccgcctgg cgcgcgcccc ccccccccgc ccccatcgct gcacaaaata 32100

attaaaaaat aaataaatac aaaattgggg gtggggaggg gggggagatg gggagagtga 32160

agcagaacgt ggggatccgc gatccattaa ttaaggggat tccatatggt acgtacatcg 32220

cctctcctac gagctcctgc agcagcgcca gaagttcacc tgcctggtcg gagtcaaccc 32280

catcgtcatc acccagcagt cgggcgatac caaggggtgc atccactgct cctgcgactc 32340

ccccgactgc gtccacactc tgatcaagac cctctgcggc ctccgcgacc tcctccccat 32400

gaactaatca cccccttatc cagtgaaata aagatcatat tgatgatgat tttacagaaa 32460

taaagataca atcatattga tgatttgagt ttaataaaaa ataaagaatc acttacttga 32520

aatctgatac caggtctctg tccatgtttt ctgccaacac cacttcactc ccctcttccc 32580

agctctggta ctgcaggccc cggcgggctg caaacttcct ccacacgctg aaggggatgt 32640

caaattcctc ctgtccctca atcttcattt tatcttctat cagatgtcca aaaagcgcgt 32700

ccgggtggat gatgacttcg accccgtcta cccctacgat gcagacaacg caccgaccgt 32760

gcccttcatc aaccccccct tcgtctcttc agatggattc caagagaagc ccctgggggt 32820

gctgtccctg cgactggccg accccgtcac caccaagaac ggggaaatca ccctcaagct 32880

gggagagggg gtggacctcg actcctcggg aaaactcatc tccaacacgg ccaccaaggc 32940

cgccgcccct ctcagttttt ccaacaacac catttccctt aacatggatc acccctttta 33000

cactaaagat ggaaaattat ccttacaagt ttctccacca ttaaatatac tgagaacaag 33060

cattctaaac acactagctt taggttttgg atcaggttta ggactccgtg gctctgcctt 33120

ggcagtacag ttagtctctc cacttacatt tgatactgat ggaaacataa agcttacctt 33180

agacagaggt ttgcatgtta caacaggaga tgcaattgaa agcaacataa gctgggctaa 33240

aggtttaaaa tttgaagatg gagccatagc aaccaacatt ggaaatgggt tagagtttgg 33300

aagcagtagt acagaaacag gtgttgatga tgcttaccca atccaagtta aacttggatc 33360

tggccttagc tttgacagta caggagccat aatggctggt aacaaagaag acgataaact 33420

cactttgtgg acaacacctg atccatcgcc aaactgtcaa atactcgcag aaaatgatgc 33480

aaaactaaca ctttgcttga ctaaatgtgg tagtcaaata ctggccactg tgtcagtctt 33540

agttgtagga agtggaaacc taaaccccat tactggcacc gtaagcagtg ctcaggtgtt 33600

tctacgtttt gatgcaaacg gtgttctttt aacagaacat tctacactaa aaaaatactg 33660

ggggtatagg cagggagata gcatagatgg cactccatat accaatgctg taggattcat 33720

gcccaattta aaagcttatc caaagtcaca aagttctact actaaaaata atatagtagg 33780

gcaagtatac atgaatggag atgtttcaaa acctatgctt ctcactataa ccctcaatgg 33840

tactgatgac agcaacagta catattcaat gtcattttca tacacctgga ctaatggaag 33900

ctatgttgga gcaacatttg gggctaactc ttataccttc tcatacatcg cccaagaatg 33960

aacactgtat cccaccctgc atgccaaccc ttcccacccc actctgtgga aaaaactctg 34020

aaacacaaaa taaaataaag ttcaagtgtt ttattgattc aacagtttta caggattcga 34080

gcagttattt ttcctccacc ctcccaggac atggaataca ccaccctctc cccccgcaca 34140

gccttgaaca tctgaacgcc attggtgatg gacatgcttt tggtctccac gttccacaca 34200

gtttcagagc gagccagtct cgggtcggtc agggagatga aaccctccgg gcacaattgg 34260

gagaagtact cgcctattat ctggaagaag cagaagagcg gcggtgggaa tcatagtccg 34320

cgaacgggat cggccggtgg tgtcgcatca ggccccgcag cagtcgctgc cgccgccgct 34380

ccgtcaagct gctgctcagg gggtccgggt ccagggactc cctcagcatg atgcccacgg 34440

ccctcagcat cagtcgtctg gtgcggcggg cgcagcagcg catgcggatc tcgctcaggt 34500

cgctgcagta cgtgcaacac agaaccacca ggttgttcaa cagtccatag ttcaacacgc 34560

tccagccgaa actcatcgcg ggaaggatgc tacccacgtg gccgtcgtac cagatcctca 34620

ggtaaatcaa gtggtgcccc ctccagaaca cgctgcccac gtacatgatc tccttgggca 34680

tgtggcggtt caccacctcc cggtaccaca tcaccctctg gttgaacatg cagccccgga 34740

tgatcctgcg gaaccacagg gccagcaccg ccccgcccgc catgcagcga agagaccccg 34800

ggtcccggca atggcaatgg aggacccacc gctcgtaccc gtggatcatc tgggagctga 34860

acaagtctat gttggcacag cacaggcata tgctcatgca tctcttcagc actctcaact 34920

cctcgggggt caaaaccata tcccagggca cggggaactc ttgcaggaca gcgaaccccg 34980

cagaacaggg caatcctcgc acagaactta cattgtgcat ggacagggta tcgcaatcag 35040

gcagcaccgg gtgatcctcc accagagaag cgcgggtctc ggtctcctca cagcgtggta 35100

agggggccgg ccgatacggg tgatggcggg acgcggctga tcgtgttcgc gaccgtgtca 35160

tgatgcagtt gctttcggac atatttcctg aagtcttggc gcgccaaagt ctagacagcg 35220

tccatagctt accgagcagc agcagcagca cacaacaggc gcaagagtca gagaaaggct 35280

gagctctaac ctgtccaccc gctctctgct caatatatag cccagatcta cactgacgta 35340

aaggccaaag tctaaaaata cccgccaaat agtcacacac gcccagcaca cgcccagaaa 35400

ccggtgacac actcaaaaaa atacgcgcac ttcctcaaac gcccaaactg ccgtcatttc 35460

cgggttccca cgctacgtca tcaaaacacg actttcaaat tccgtcgacc gttaaaaacg 35520

tcacccgccc cgcccctaac ggtcgcccgt ctctcagcca atcagcgccc cgcatcccca 35580

aattcaaaca cctcatttgc atattaacgc gcaccaaaag tttgaggtat attattgatg 35640

atgatttaaa tggcgcgccg ggcccgggc 35669

<210> 18

<211> 33410

<212> DNA

<213> Artificial Sequence

<400> 18

aaatcatcat caataatata cctcaaactt ttggtgcgcg ttaatatgca aatgaggtgt 60

ttgaatttgg ggatgcgggg cgctgattgg ctgagagacg ggcgaccgtt aggggcgggg 120

cgggtgacgt tttgatgacg tggccgtgag gcggagccgg tttgcaagtt ctcgtgggaa 180

aagtgacgtc aaacgaggtg tggtttgaac acggaaatac tcaattttcc cgcgctctct 240

gacaggaaat gaggtgtttc tgggcggatg caagtgaaaa cgggccattt tcgcgcgaaa 300

actgaatgag gaagtgaaaa tctgagtaat tccgcgttta tggcagggag gagtatttgc 360

cgagggccga gtagactttg accgattacg tgggggtttc gattaccgta tttttcacct 420

aaatttccgc gtacggtgtc aaagtccggt gtttttacgt aggcgtcagc tgatcgccag 480

ggtatttaaa cctgcgctct ctagtcaaga ggccactctt gagtgccagc gagtagagtt 540

ttctcctccg cgccgcgagt cagatctaca ctttgaaagg cgatcgccga tatcatttcc 600

ccgaaaagtg ccacctgacc gtaactataa cggtcctaag gtagcgaaag ctcagatctc 660

ccgatcccct atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt 720

atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta 780

caacaaggca aggcttgacc gacaattgca tgaagaatct gcttagggtt aggcgttttg 840

cgctgcttcg cgatgtacgg gccagatata cgcgttgaca ttgattattg actagttatt 900

aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat 960

aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa 1020

taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg 1080

agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc 1140

cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct 1200

tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga 1260

tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa 1320

gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc 1380

caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg 1440

aggtctatat aagcagagct cgtttagtga accgtcagat cactagaagc tttattgcgg 1500

tagtttatca cagttaaatt gctaacgcag tcagtgcttc tgacacaaca gtctcgaact 1560

taagctgcag aagttggtcg tgaggcactg ggcaggtaag tatcaaggtt acaagacagg 1620

tttaaggaga ccaatagaaa ctgggcttgt cgagacagag aagactcttg cgtttctgat 1680

aggcacctat tggtcttact gacatccact ttgcctttct ctccacaggt gtccactccc 1740

agttcaatta cagctcttaa ggctagagta ctctagcccg ggatccaccg gtcgccacca 1800

tgtttcagga tccccaggag cggggccgca agctgccaca gctgtgcaca gagctccaga 1860

caaccattca cgatattatt ctcgagtgcg tctactgtaa gcagcagctc ctgcgccggg 1920

aggtctacga cttcgctaga cgcgacctgt gtatcgtcta ccgcgatgga aatccatacg 1980

ccgtcggcga taagtgcctc aagttttact ctaagatttc tgagtaccgg cactactgtt 2040

actcactgta cggaaccacc ctcgagcagc agtacaataa gcctctgtgt gatctgctca 2100

ttagatgcat taatggccag aagcctctct gtccagagga gaagcagcgg cacctcgata 2160

agaagcagcg gtttcacaat actaggggaa ggtggaccgg aaggtgtatg tcatgttgtc 2220

ggtcatcaag aactagacgc gagacacagc tcagaaagag gcgcgggtca ggcgcaccag 2280

tcaagcagac tctgaacttt gatctcctca agctcgctgg cgacgtcgag tctaatcctg 2340

gccccccacgg cgacacccca accctccacg agtacatgct ggatctccag cccgagacaa 2400

ccgacctcta cgggtacggg cagctcaatg attcatcaga ggaggaggat gagattgatg 2460

gccccgccgg acaggctgag cccgataggg cccactacaa tatcgtgaca ttttgttgca 2520

agggcgattc aacactccgc ctgtgcgtgc agtcaaccca cgtggatatt cggactctcg 2580

aggatctgct catgggaaca ctgggaattg tgtgccctat ttgttcccag aagcctagaa 2640

agaggcgcgg gtccggcgca acaaatttta gcctgctcaa gcaggctggc gacgtcgagg 2700

agaatcctgg gcccgctagg tttgaggatc caactagacg cgggtacaag ctccccgatc 2760

tgtgtacaga gctgaataca tcactccagg atattgagat tacttgcgtg tactgtaaga 2820

ccgtcctcga gctgactgag gtctttgagt tcgctagaaa ggatctcttc gtggtctacc 2880

gggattctat cccacacgcc gccggacaca agtgcattga cttttactct cgcattaggg 2940

agctcaggca ctactccgat agcgtctacg gggatacact ggagaagctg actaatactg 3000

gactgtacaa tctgctcatt agatgcctgc gcggacagaa gcctctcaat cccgctgaga 3060

agctgcggca cctgaatgag aagagacggt ttcacaatac cgccggacac taccggggcc 3120

agtgtcactc ttgttgtaat agggctaggc aggagcggct ccagagacgc cgcgagactc 3180

aggtccgcaa gaggcgcggg tccggcgcac ccgtgaagca gaccctgaac tttgatctcc 3240

tgaagctcgc tggggacgtg gagtctaacc ctgggccaca cggaccaaag gctaccctcc 3300

aggatatcgt cctgcacctc gagccacaga atgagattcc cgtcgacctg ctcggccacg 3360

gacagctgtc cgatagcgag gaggagaacg atgagattga tggggtgaat caccagcacc 3420

tgcccgctag acgcgccgag ccacagcggc acaccatgct gtgtatgtgt tgcaaggggg 3480

aggcacgcat cgagctggtg gtggagtctt ccgccgatga cctcagggct tttcagcagc 3540

tctttctgaa taccctgtcc ttcgtgtgcc cttggtgcgc ttcccagcag tgaagcggcc 3600

gccactgtgc tggatgatcc gagctcggta cctctagagt cgacccgggc ggccaaaccg 3660

ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt 3720

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat 3780

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag 3840

caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc 3900

ttctgaggcg gaaagaacca gcagatctgc agatctgaat tcatctatgt cgggtgcgga 3960

gaaagaggta atgaaatggc attatgggta ttatgggtct gcattaatga atcggccaga 4020

tatcgacata tgctggccac cgtacatgtg gcttcccatg ctcgcaagcc ctggcccgag 4080

ttcgagcaca atgtcatgac caggtgcaat atgcatctgg ggtcccggcg atcgcccgag 4140

gcatgttcat gccctaccag tgcaacatgc aatttgtgaa ggtgctgctg gagcccgatg 4200

ccatgtccag agtgagcctg acgggggtgt ttgacatgaa tgtggagctg tggaaaattc 4260

tgagatatga tgaatccaag accaggtgcc gggcctgcga atgcggaggc aagcacgcca 4320

ggcttcagcc cgtgtgtgtg gaggtgacgg aggacctgcg acccgatcat ttggtgttgt 4380

cctgcaacgg gacggagttc ggctccagcg gggaagaatc tgactagagt gagtagtgtt 4440

tgggggtggg tgggagcctg catgatgggc agaatgacta aaatctgtgt ttttctgtgt 4500

gttgcagcag catgagcgga agcgcctcct ttgagggagg ggtattcagc ccttatctga 4560

cggggcgtct cccctcctgg gcgggagtgc gtcagaatgt gatgggatcc acggtggacg 4620

gccggcccgt gcagcccgcg aactcttcaa ccctgaccta cgcgaccctg agctcctcgt 4680

ccgtggacgc agctgccgcc gcagctgctg cttccgccgc cagcgccgtg cgcggaatgg 4740

ccctgggcgc cggctactac agctctctgg tggccaactc gagttccacc aataatcccg 4800

ccagcctgaa cgaggagaag ctgttgctgc tgatggccca gctcgaggcc ctgacccagc 4860

gcctgggcga gctgacccag caggtggctc agctgcaggc ggagacgcgg gccgcggttg 4920

ccacggtgaa aaccaaataa aaaatgaatc aataaataaa cggagacggt tgttgatttt 4980

aacacagagt cttgaatctt tatttgattt ttcgcgcgcg gtaggccctg gaccaccggt 5040

ctcgatcatt gagcacccgg tggatctttt ccaggacccg gtagaggtgg gcttggatgt 5100

tgaggtacat gggcatgagc ccgtcccggg ggtggaggta gctccattgc agggcctcgt 5160

gctcgggggt ggtgttgtaa atcacccagt catagcaggg gcgcagggcg tggtgctgca 5220

cgatgtcttt gaggaggaga ctgatggcca cgggcagccc cttggtgtag gtgttgacga 5280

acctattgag ctgggaggga tgcatgcggg gggagatgag atgcatcttg gcctggatct 5340

tgagattggc gatgttcccg cccagatccc gccgggggtt catgttgtgc aggaccacca 5400

gcacggtgta tccggtgcac ttggggaatt tgtcatgcaa cttggaaggg aaggcgtgaa 5460

agaatttgga gacgcccttg tgaccgccca ggttttccat gcactcatcc atgatgatgg 5520

cgatggggccc gtgggcggcg gcctgggcaa agacgtttcg ggggtcggac acatcgtagt 5580

tgtggtcctg ggtgagctcg tcataggcca ttttaatgaa tttggggcgg agggtacccg 5640

actgggggac aaaggtgccc tcgatcccgg gggcgtagtt cccctcgcag atctgcatct 5700

cccaggcctt gagctcggag ggggggatca tgtccacctg cggggcgatg aaaaaaacgg 5760

tttccggggc gggggagatg agctgcgccg aaagcaggtt ccggagcagc tgggacttgc 5820

cgcagccggt ggggccgtag atgaccccga tgaccggctg caggtggtag ttgagggaga 5880

gacagctgcc gtcctcgcgg aggagggggg ccacctcgtt catcatctcg cgcacatgca 5940

tgttctcgcg cacgagttcc gccaggaggc gctcgccccc cagcgagagg agctcttgca 6000

gcgaggcgaa gtttttcagc ggcttgagcc cgtcggccat gggcattttg gagagggtct 6060

gttgcaagag ttccagacgg tcccaagagct cggtgatgtg ctctagggca tctcgatcca 6120

gcagacctcc tcgtttcgcg ggttggggcg actgcgggag tagggcacca ggcgatgggc 6180

gtccagcgag gccagggtcc ggtccttcca gggtcgcagg gtccgcgtca gcgtggtctc 6240

cgtcacggtg aaggggtgcg cgccgggctg ggcgcttgcg agggtgcgct tcaggctcat 6300

ccggctggtc gagaaccgct cccggtcggc gccctgcgcg tcggccaggt agcaattgag 6360

catgagttcg tagttgagcg cctcggccgc gtggcccttg gcgcggagct tacctttgga 6420

agtgtgtccg cagacgggac agaggaggga cttgagggcg tagagcttgg gggcgaggaa 6480

gacggactcg ggggcgtagg cgtccgcgcc gcagctggcg cagacggtct cgcactccac 6540

gagccaggtg aggtcggggc ggtcggggtc aaaaacgagg tttcctccgt gctttttgat 6600

gcgtttctta cctctggtct ccatgagctc gtgtccccgc tgggtgacaa agaggctgtc 6660

cgtgtccccg tagaccgact ttatgggccg gtcctcgagc ggggtgccgc ggtcctcgtc 6720

gtagaggaac cccgcccact ccgagacgaa ggcccgggtc caggccagca cgaaggaggc 6780

cacgtgggag gggtagcggt cgttgtccac cagcgggtcc accttctcca gggtatgcaa 6840

gcacatgtcc ccctcgtcca catccaggaa ggtgattggc ttgtaagtgt aggccacgtg 6900

accgggggtc ccggccgggg gggtataaaa gggggcgggc ccctgctcgt cctcactgtc 6960

ttccggatcg ctgtccagga gcgccagctg ttggggtagg tattccctct cgaaggcggg 7020

catgacctcg gcactcaggt tgtcagtttc tagaaacgag gaggatttga tattgacggt 7080

gccgttggag acgcctttca tgagcccctc gtccatctgg tcagaaaaga cgatcttttt 7140

gttgtcgagc ttggtggcga aggagccgta gagggcgttg gagagcagct tggcgatgga 7200

gcgcatggtc tggttctttt ccttgtcggc gcgctccttg gcggcgatgt tgagctgcac 7260

gtactcgcgc gccacgcact tccattcggg gaagacggtg gtgagctcgt cgggcacgat 7320

tctgacccgc cagccgcggt tgtgcagggt gatgaggtcc acgctggtgg ccacctcgcc 7380

gcgcaggggc tcgttggtcc agcagaggcg cccgcccttg cgcgagcaga aggggggcag 7440

cgggtccagc atgagctcgt cgggggggtc ggcgtccacg gtgaagatgc cgggcaggag 7500

ctcggggtcg aagtagctga tgcaggtgcc cagatcgtcc agacttgctt gccagtcgcg 7560

cacggccagc gcgcgctcgt aggggctgag gggcgtgccc cagggcatgg ggtgcgtgag 7620

cgcggaggcg tacatgccgc agatgtcgta gacgtagagg ggctcctgga ggacgccgat 7680

gtaggtgggg tagcagcgcc ccccgcggat gctggcgcgc acgtagtcgt acagctcgtg 7740

cgagggcgcg aggagccccg tgccgagatt ggagcgctgc ggcttttcgg cgcggtagac 7800

gatctggcgg aagatggcgt gggagttgga ggagatggtg ggcctctgga agatgttgaa 7860

gtgggcatgg ggcagtccga ccgagtccct gatgaagtgg gcgtaggagt cctgcagctt 7920

ggcgacgagc tcggcggtga cgaggacgtc cagggcgcag tagtcgaggg tctcttggat 7980

gatgtcgtac ttgagctggc ccttctgctt ccacagctcg cggttgagaa ggaactcttc 8040

gcggtccttc cagtactctt cgagggggaa cccgtcctga tcggcacggt aagagcccac 8100

catgtagaac tggttgacgg ccttgtaggc gcagcagccc ttctccacgg ggagggcgta 8160

agcttgcgcg gccttgcgca gggaggtgtg ggtgagggcg aaggtgtcgc gcaccatgac 8220

tttgaggaac tggtgcttga agtcgaggtc gtcgcagccg ccctgctccc agagctggaa 8280

gtccgtgcgc ttcttgtagg cggggttggg caaagcgaaa gtaacatcgt tgaagaggat 8340

cttgcccgcg cggggcatga agttgcgagt gatgcggaaa ggctggggca cctcggcccg 8400

gttgttgatg acctgggcgg cgaggacgat ctcgtcgaag ccgttgatgt tgtgcccgac 8460

gatgtagagt tccacgaatc gcgggcggcc cttgacgtgg ggcagcttct tgagctcgtc 8520

gtaggtgagc tcggcggggt cgctgagccc gtgctgctcg agggcccagt cggcgacgtg 8580

ggggttggcg ctgaggaagg aagtccagag atccacggcc agggcggtct gcaagcggtc 8640

ccggtactga cggaactgct ggcccacggc cattttttcg ggggtgacgc agtagaaggt 8700

gcgggggtcg ccgtgccagc ggtcccactt gagctggagg gcgaggtcgt gggcgagctc 8760

gacgagcggc gggtccccgg agagtttcat gaccagcatg aaggggacga gctgcttgcc 8820

gaaggacccc atccaggtgt aggtttccac atcgtaggtg aggaagagcc tttcggtgcg 8880

aggatgcgag ccgatgggga agaactggat ctcctgccac cagttggagg aatggctgtt 8940

gatgtgatgg aagtagaaat gccgacggcg cgccgagcac tcgtgcttgt gtttatacaa 9000

gcgtccgcag tgctcgcaac gctgcacggg atgcacgtgc tgcacgagct gtacctgggt 9060

tcctttgacg aggaatttca gtgggcagtg gagcgctggc ggctgcatct ggtgctgtac 9120

tacgtcctgg ccatcggcgt ggccatcgtc tgcctcgatg gtggtcatgc tgacgagccc 9180

gcgcgggagg caggtccaga cctcggctcg gacgggtcgg agagcgagga cgagggcgcg 9240

caggccggag ctgtccaggg tcctgagacg ctgcggagtc aggtcagtgg gcagcggcgg 9300

cgcgcggttg acttgcagga gcttttccag ggcgcgcggg aggtccagat ggtacttgat 9360

ctccacggcg ccgttggtgg cgacgtccac ggcttgcagg gtcccgtgcc cctggggcgc 9420

caccaccgtg ccccgtttct tcttgggcgg cggcggctcc atgcttagaa gcggcggcga 9480

ggacgcgcgc cgggcggcag gggcggctcg gggcccggag gcaggggcgg caggggcacg 9540

tcggcgccgc gcgcgggcag gttctggtac tgcgcccgga gaagactggc gtgagcgacg 9600

acgcgacggt tgacgtcctg gatctgacgc ctctgggtga aggccacggg acccgtgagt 9660

ttgaacctga aagagagttc gacagaatca atctcggtat cgttgacggc ggcctgccgc 9720

aggatctctt gcacgtcgcc cgagttgtcc tggtaggcga tctcggtcat gaactgctcg 9780

atctcctcct cctgaaggtc tccgcggccg gcgcgctcga cggtggccgc gaggtcgttg 9840

gagatgcggc ccatgagctg cgagaaggcg ttcatgccgg cctcgttcca gacgcggctg 9900

tagaccacgg ctccgtcggg gtcgcgcgcg cgcatgacca cctgggcgag gttgagctcg 9960

acgtggcgcg tgaagaccgc gtagttgcag aggcgctggt agaggtagtt gagcgtggtg 10020

gcgatgtgct cggtgacgaa gaagtacatg atccagcggc ggagcggcat ctcgctgacg 10080

tcgcccaggg cttccaagcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac 10140

tgggagttgc gcgccgagac ggtcaactcc tcctccagaa gacggatgag ctcggcgatg 10200

gtggcgcgca cctcgcgctc gaaggccccg gggggctcct cttccatttc ctcctcttcc 10260

tcctccacta acatctcttc tacttcctcc tcaggaggcg gcggcggggg aggggccctg 10320

cgtcgccggc ggcgcacggg cagacggtcg atgaagcgct cgatggtctc cccgcgccgg 10380

cgacgcatgg tctcggtgac ggcgcgcccg tcctcgcggg gccgcagcgt gaagacgccg 10440

ccgcgcatct ccaggtggcc gccggggggg tctccgttgg gcagggagag ggcgctgacg 10500

atgcatctta tcaattgacc cgtagggact ccgcgcaagg acctgagcgt ctcgagatcc 10560

acgggatccg aaaaccgctg aacgaaggct tcgagccagt cgcagtcgca aggtaggctg 10620

agcccggttt cttgttcttc gggtatttgg tcgggaggcg ggcgggcgat gctgctggtg 10680

atgaagttga agtaggcggt cctgagacgg cggatggtgg cgaggagcac caggtccttg 10740

ggcccggctt gctggatgcg cagacggtcg gccatgcccc aggcgtggtc ctgacacctg 10800

gcgaggtcct tgtagtagtc ctgcatgagc cgctccacgg gcacctcctc ctcgcccgcg 10860

cggccgtgca tgcgcgtgag cccgaacccg cgctgcggct ggacgagcgc caggtcggcg 10920

acgacgcgct cggcgaggat ggcctgctgg atctgggtga gggtggtctg gaagtcgtcg 10980

aagtcgacga agcggtggta ggctccggtg ttgatggtgt aggagcagtt ggccatgacg 11040

gaccagttga cggtctggtg gccggggcgc acgagctcgt ggtacttgag gcgcgagtag 11100

gcgcgcgtgt cgaagatgta gtcgttgcag gtgcgcacga ggtactggta tccgacgagg 11160

aagtgcggcg gcggctggcg gtagagcggc catcgctcgg tggcgggggc gccgggcgcg 11220

aggtcctcga gcatgaggcg gtggtagccg tagatgtacc tggacatcca ggtgatgccg 11280

gcggcggtgg tggaggcgcg cgggaactcg cggacgcggt tccagatgtt gcgcagcggc 11340

aggaagtagt tcatggtggc cgcggtctgg cccgtgaggc gcgcgcagtc gtggatgctc 11400

tagacatacg ggcaaaaacg aaagcggtca gcggctcgac tccgtggcct ggaggctaag 11460

cgaacgggtt gggctgcgcg tgtaccccgg ttcgaatctc gaatcaggct ggagccgcag 11520

ctaacgtggt actggcactc ccgtctcgac ccaagcctgc taacgaaacc tccaggatac 11580

ggaggcgggt cgtttttttgg ccttggtcgc tggtcatgaa aaactagtaa gcgcggaaag 11640

cggccgcccg cgatggctcg ctgccgtagt ctggagaaag aatcgccagg gttgcgttgc 11700

ggtgtgcccc ggttcgagcc tcagcgctcg gcgccggccg gattccgcgg ctaacgtggg 11760

cgtggctgcc ccgtcgtttc caagacccct tagccagccg acttctccag ttacggagcg 11820

agcccctctt ttttttcttgt gtttttgcca gatgcatccc gtactgcggc agatgcgccc 11880

ccaccctcca ccacaaccgc ccctaccgca gcagcagcaa cagccggcgc ttctgccccc 11940

gccccagcag cagcagccag ccactaccgc ggcggccgcc gtgagcggag ccggcgttca 12000

gtatgacctg gccttggaag agggcgaggg gctggcgcgg ctgggggcgt cgtcgccgga 12060

gcggcacccg cgcgtgcaga tgaaaaggga cgctcgcgag gcctacgtgc ccaagcagaa 12120

cctgttcaga gacaggagcg gcgaggagcc cgaggagatg cgcgcctccc gcttccacgc 12180

ggggcgggag ctgcggcgcg gcctggaccg aaagcgggtg ctgagggacg aggatttcga 12240

ggcggacgag ctgacgggga tcagccccgc gcgcgcgcac gtggccgcgg ccaacctggt 12300

cacggcgtac gagcagaccg tgaaggagga gagcaacttc caaaaatcct tcaacaacca 12360

cgtgcgcacg ctgatcgcgc gcgaggaggt gaccctgggc ctgatgcacc tgtgggacct 12420

gctggaggcc atcgtgcaga accccacgag caagccgctg acggcgcagc tgtttctggt 12480

ggtgcagcac agtcgggaca acgagacgtt cagggaggcg ctgctgaata tcaccgagcc 12540

cgagggccgc tggctcctgg acctggtgaa cattctgcag agcatcgtgg tgcaggagcg 12600

cgggctgccg ctgtccgaga agctggcggc catcaacttc tcggtgctga gcctgggcaa 12660

gtactacgct aggaagatct acaagacccc gtacgtgccc atagacaagg aggtgaagat 12720

cgatgggttt tacatgcgca tgaccctgaa agtgctgacc ctgagcgacg atctgggggt 12780

gtaccgcaac gacaggatgc accgcgcggt gagcgccagc cgccggcgcg agctgagcga 12840

ccaggagctg atgcacagcc tgcagcgggc cctgaccggg gccgggaccg agggggagag 12900

ctactttgac atgggcgcgg acctgcgctg gcagcccagc cgccgggcct tggaagctgc 12960

cggcggcgtg ccctacgtgg aggaggtgga cgatgaggag gaggagggcg agtacctgga 13020

agactgatgg cgcgaccgta tttttgctag atgcagcaac agccaccgcc gccgcctcct 13080

gatcccgcga tgcgggcggc gctgcagagc cagccgtccg gcattaactc ctcggacgat 13140

tggacccagg ccatgcaacg catcatggcg ctgacgaccc gcaatcccga agcctttaga 13200

cagcagcctc aggccaaccg gctctcggcc atcctggagg ccgtggtgcc ctcgcgctcg 13260

aaccccacgc acgagaaggt gctggccatc gtgaacgcgc tggtggagaa caaggccatc 13320

cgcggcgacg aggccgggct ggtgtacaac gcgctgctgg agcgcgtggc ccgctacaac 13380

agcaccaacg tgcagacgaa cctggaccgc atggtgaccg acgtgcgcga ggcggtgtcg 13440

cagcgcgagc ggttccaccg cgagtcgaac ctgggctcca tggtggcgct gaacgccttc 13500

ctgagcacgc agcccgccaa cgtgccccgg ggccaggagg actacaccaa cttcatcagc 13560

gcgctgcggc tgatggtggc cgaggtgccc cagagcgagg tgtaccagtc ggggccggac 13620

tacttcttcc agaccagtcg ccagggcttg cagaccgtga acctgagcca ggctttcaag 13680

aacttgcagg gactgtgggg cgtgcaggcc ccggtcgggg accgcgcgac ggtgtcgagc 13740

ctgctgacgc cgaactcgcg cctgctgctg ctgctggtgg cgcccttcac ggacagcggc 13800

agcgtgagcc gcgactcgta cctgggctac ctgcttaacc tgtaccgcga ggccatcggg 13860

caggcgcacg tggacgagca gacctaccag gagatcaccc acgtgagccg cgcgctgggc 13920

caggaggacc cgggcaacct ggaggccacc ctgaacttcc tgctgaccaa ccggtcgcag 13980

aagatcccgc cccagtacgc gctgagcacc gaggaggagc gcatcctgcg ctacgtgcag 14040

cagagcgtgg ggctgttctt gatgcaggag ggggccacgc ccagcgccgc gctcgacatg 14100

accgcgcgca acatggagcc cagcatgtac gcccgcaacc gcccgttcat caataagctg 14160

atggactact tgcatcgggc ggccgccatg aactcggact actttaccaa cgccatcttg 14220

aacccgcact ggctcccgcc gcccgggttc tacacgggcg agtacgacat gcccgacccc 14280

aacgacgggt tcctgtggga cgacgtggac agcagcgtgt tctcgccgcg gcccaccacc 14340

accaccgtgt ggaagaaaga gggcggggac cggcggccgt cctcggcgct gtccggtcgc 14400

gcgggtgctg ccgcggcggt gcccgaggct gccagcccct tcccgagcct gcccttttcg 14460

ctgaacagcg tgcgcagcag cgagctgggt cggctgacgc ggccgcgcct gctgggcgag 14520

gaggagtacc tgaacgactc cttgttgaag cccgagcgcg agaagaactt ccccaataac 14580

gggatagaga gcctggtgga caagatgagc cgctggaaga cgtacgcgca cgagcacagg 14640

gacgagcccc gagctagcag cgcaggcacc cgtagacgcc agcggcacga caggcagcgg 14700

ggactggtgt gggacgatga ggattccgcc gacgacagca gcgtgttgga cttgggtggg 14760

agtggtggtg gtaacccgtt cgctcacctg cgccccccgta tcgggcgcct gatgtaagaa 14820

tctgaaaaaa taaaagacgg tactcaccaa ggccatggcg accagcgtgc gttcttctct 14880

gttgtttgta gtagtatgat gaggcgcgtg tacccggagg gtcctcctcc ctcgtacgag 14940

agcgtgatgc agcaggcggt ggcggcggcg atgcagcccc cgctggaggc gccttacgtg 15000

cccccgcggt acctggcgcc tacggagggg cggaacagca ttcgttactc ggagctggca 15060

cccttgtacg ataccacccg gttgtacctg gtggacaaca agtcggcgga catcgcctcg 15120

ctgaactacc agaacgacca cagcaacttc ctgaccaccg tggtgcagaa caacgatttc 15180

acccccacgg aggccagcac ccagaccatc aactttgacg agcgctcgcg gtggggcggc 15240

cagctgaaaa ccatcatgca caccaacatg cccaacgtga acgagttcat gtacagcaac 15300

aagttcaagg cgcgggtgat ggtctcgcgc aagaccccca acggggtcac ggtaggggat 15360

gattatgatg gtagtcagga cgagctgacc tacgagtggg tggagtttga gctgcccgag 15420

ggcaacttct cggtgaccat gaccatcgat ctgatgaaca acgccatcat cgacaactac 15480

ttggcggtgg ggcggcagaa cggggtgctg gagagcgaca tcggcgtgaa gttcgacacg 15540

cgcaacttcc ggctgggctg ggaccccgtg accgagctgg tgatgccggg cgtgtacacc 15600

aacgaggcct tccaccccga catcgtcctg ctgcccggct gcggcgtgga cttcaccgag 15660

agccgcctca gcaacctgct gggcatccgc aagcggcagc ccttccagga gggcttccag 15720

atcctgtacg aggacctgga ggggggcaac atccccgcgc tcttggatgt cgaagcctat 15780

gaagaaagta aggaaaaagc agaggctgag gcaactacag ccgtggctac cgccgcgact 15840

gtggcagatg ccactgtcac caggggcgat acattcgcca cccaggcgga ggaagcagcc 15900

gccctagcgg cgaccgatga tagtgaaagt aagatagtca tcaagccggt ggagaaggac 15960

agcaagaaca ggagctacaa cgttctaccg gatggaaaga acaccgccta ccgcagctgg 16020

tacctggcct acaactacgg cgaccccgag aagggcgtgc gctcctggac gctgctcacc 16080

acctcggacg tcacctgcgg cgtggagcaa gtctactggt cgctgcccga catgatgcaa 16140

gacccggtca ccttccgctc cacgcgacaa gttagcaact acccggtggt gggcgccgag 16200

ctcctgcccg tctactccaa gagcttcttc aacgagcagg ccgtctactc gcagcagctg 16260

cgtgccttca cctcgctcac gcacgtcttc aaccgcttcc ccgagaacca gatcctcgtc 16320

cgcccgcccg cgcccaccat taccaccgtc agtgaaaacg ttcctgctct cacagatcac 16380

gggaccctgc cgctgcgcag cagtatccgg ggagtccagc gcgtgaccgt cactgacgcc 16440

agacgccgca cctgccccta cgtctacaag gccctgggcg tagtcgcgcc gcgcgtcctc 16500

tcgagccgca ccttctaaaa aatgtccatt ctcatctcgc ccagtaataa caccggttgg 16560

ggcctgcgcg cgcccagcaa gatgtacgga ggcgctcgcc aacgctccac gcaacacccc 16620

gtgcgcgtgc gcgggcactt ccgcgctccc tggggcgccc tcaagggccg cgtgcgctcg 16680

cgcaccaccg tcgacgacgt gatcgaccag gtggtggccg acgcgcgcaa ctacacgccc 16740

gccgccgcgc ccgcctccac cgtggacgcc gtcatcgaca gcgtggtggc cgacgcgcgc 16800

cggtacgccc gcgccaagag ccggcggcgg cgcatcgccc ggcggcaccg gagcaccccc 16860

gccatgcgcg cggcgcgagc cttgctgcgc agggccaggc gcacgggacg cagggccatg 16920

ctcagggcgg ccagacgcgc ggcctccggc agcagcagcg ccggcaggac ccgcagacgc 16980

gcggccacgg cggcggcggc ggccatcgcc agcatgtccc gcccgcggcg cggcaacgtg 17040

tactgggtgc gcgacgccgc caccggtgtg cgcgtgcccg tgcgcacccg cccccctcgc 17100

acttgaagat gctgacttcg cgatgttgat gtgtcccagc ggcgaggagg atgtccaagc 17160

gcaaatacaa ggaagagatg ctccaggtca tcgcgcctga gatctacggc cccgcggcgg 17220

cggtgaagga ggaaagaaag ccccgcaaac tgaagcgggt caaaaaggac aaaaaggagg 17280

aggaagatga cggactggtg gagtttgtgc gcgagttcgc cccccggcgg cgcgtgcagt 17340

ggcgcgggcg gaaagtgaaa ccggtgctgc ggcccggcac cacggtggtc ttcacgcccg 17400

gcgagcgttc cggctccgcc tccaagcgct cctacgacga ggtgtacggg gacgaggaca 17460

tcctcgagca ggcggtcgag cgtctgggcg agtttgctta cggcaagcgc agccgccccg 17520

cgcccttgaa agaggaggcg gtgtccatcc cgctggacca cggcaacccc acgccgagcc 17580

tgaagccggt gaccctgcag caggtgctgc cgagcgcggc gccgcgccgg ggcttcaagc 17640

gcgagggcgg cgaggatctg tacccgacca tgcagctgat ggtgcccaag cgccagaagc 17700

tggaggacgt gctggagcac atgaaggtgg accccgaggt gcagcccgag gtcaaggtgc 17760

ggcccatcaa gcaggtggcc ccgggcctgg gcgtgcagac cgtggacatc aagatcccca 17820

cggagcccat ggaaacgcag accgagcccg tgaagcccag caccagcacc atggaggtgc 17880

agacggatcc ctggatgcca gcggcttcca ccaccaccac tcgccgaaga cgcaagtacg 17940

gcgcggccag cctgctgatg cccaactacg cgctgcatcc ttccatcatc cccacgccgg 18000

gctaccgcgg cacgcgcttc taccgcggct acaccagcag ccgccgccgc aagaccacca 18060

cccgccgccg tcgtcgcagc cgccgcagca gcaccgcgac ttccgccttg gtgcggagag 18120

tgtatcgcag cgggcgcgag cctctgaccc tgccgcgcgc gcgctaccac ccgagcatcg 18180

ccatttaact accgcctcct acttgcagat atggccctca catgccgcct ccgcgtcccc 18240

attacgggct accgaggaag aaagccgcgc cgtagaaggc tgacggggaa cgggctgcgt 18300

cgccatcacc accggcggcg gcgcgccatc agcaagcggt tgggggggagg cttcctgccc 18360

gcgctgatcc ccatcatcgc cgcggcgatc ggggcgatcc ccggcatagc ttccgtggcg 18420

gtgcaggcct ctcagcgcca ctgagacaca aaaaagcatg gatttgtaat aaaaaaatgg 18480

actgacgctc ctggtcctgt gatgtgtgtt tttagatgga agacatcaat ttttcgtccc 18540

tggcaccgcg acacggcacg cggccgttta tgggcacctg gagcgacatc ggcaacagcc 18600

aactgaacgg gggcgccttc aattggagca gtctctggag cgggcttaag aatttcgggt 18660

ccacgctcaa aacctatggc aacaaggcgt ggaacagcag cacagggcag gcgctgaggg 18720

aaaagctgaa agagcagaac ttccagcaga aggtggtcga tggcctggcc tcgggcatca 18780

acggggtggt ggacctggcc aaccaggccg tgcagaaaca gatcaacagc cgcctggacg 18840

cggtcccgcc cgcggggtcc gtggagatgc cccaggtgga ggaggagctg cctcccctgg 18900

acaagcgcgg cgacaagcga ccgcgtcccg acgcggagga gacgctgctg acgcacacgg 18960

acgagccgcc cccgtacgag gaggcggtga aactgggtct gcccaccacg cggcccgtgg 19020

cgcctctggc caccggggtg ctgaaaccca gcagcagcag ccagcccgcg accctggact 19080

tgcctccgcc tgcttcccgc ccctccacag tggctaagcc cctgccgccg gtggccgtcg 19140

cgtcgcgcgc cccccgaggc cgcccccagg cgaactggca gagcactctg aacagcatcg 19200

tgggtctggg agtgcagagt gtgaagcgcc gccgctgcta ttaaaagaca ctgtagcgct 19260

taacttgctt gtctgtgtgt gtatatgtat gtccgccgac cagaaggagg aagaggcgcg 19320

tcgccgagtt gcaagatggc caccccatcg atgctgcccc agtgggcgta catgcacatc 19380

gccggacagg acgcttcgga gtacctgagt ccgggtctgg tgcagttcgc ccgcgccaca 19440

gacacctact tcagtctggg gaacaagttt aggaacccca cggtggcgcc cacgcacgat 19500

gtgaccaccg accgcagcca gcggctgacg ctgcgcttcg tgcccgtgga ccgcgaggac 19560

aacacctact cgtacaaagt gcgctacacg ctggccgtgg gcgacaaccg cgtgctggac 19620

atggccagca cctactttga catccgcggc gtgctggatc ggggccccag cttcaaaccc 19680

tactccggca ccgcctacaa cagcctagct cccaagggag cgcccaacac ctcacagtgg 19740

aaggattccg acagcaaaat gcatactttt ggagttgctg ccatgcccgg tgttgttggt 19800

aaaaaaatag aagccgatgg tctgcctatt ggaatagatt catcctctgg aactgacacc 19860

ataatttatg ctgataaaac tttccaacca gagccacagg ttggaagtga cagttgggtc 19920

gacaccaatg gtgcagagga aaaatatgga ggtagagctc ttaaggacac tacaaacatg 19980

aagccctgct acggttcttt tgccaggcct accaacaaag aaggtggaca ggctaacata 20040

aaagattctg aaactgccag cactactcct aactatgata tagatttggc attctttgac 20100

agcaaaaata ttgcagctaa ctacgatcca gatattgtaa tgtacacaga aaatgttgag 20160

ttgcaaactc cagatactca tattgtgttt aagccaggaa cttcagatga aagttcagaa 20220

gccaatttgg gccagcaggc catgcccaac agacccaact acatcgggtt cagagacaac 20280

tttatcgggc tcatgtacta caacagcact ggcaatatgg gtgtactggc tggtcaggcc 20340

tcccagctaa atgctgtggt ggacttgcag gacagaaaca ccgaactgtc ctaccagctc 20400

ttgcttgact ctctgggtga cagaaccagg tatttcagta tgtggaatca ggcggtggac 20460

agctatgacc ccgatgtgcg cattattgaa aatcacggtg tggaggatga actccccaat 20520

tattgcttcc ctttgaatgg tgtaggcttt acagatactt accagggtgt taaagttaag 20580

acagatacag ccgctactgg taccaatgga acgcagtggg acaaagatga taccacagtc 20640

agcactgcca atgagatcca ctcaggcaat cctttcgcca tggagatcaa catccaggcc 20700

aacctgtggc ggaacttcct ctacgcgaac gtggcgctgt acctgcccga ctcctacaag 20760

tacacgccgg ccaacatcac gctgccgacc aacaccaaca cctacgatta catgaacggc 20820

cgcgtggtgg cgccctcgct ggtggacgcc tacatcaaca tcggggcgcg ctggtcgctg 20880

gaccccatgg acaacgtcaa ccccttcaac caccaccgca acgcgggcct gcgctaccgc 20940

tccatgctcc tgggcaacgg gcgctacgtg cccttccaca tccaggtgcc ccaaaagttt 21000

ttcgccatca agagcctcct gctcctgccc gggtcctaca cctacgagtg gaacttccgc 21060

aaggacgtca acatgatcct gcagagctcc ctcggcaacg acctgcgcac ggacggggcc 21120

tccatcgcct tcaccagcat caacctctac gccaccttct tccccatggc gcacaacacc 21180

gcctccacgc tcgaggccat gctgcgcaac gacaccaacg accagtcctt caacgactac 21240

ctctcggcgg ccaacatgct ctaccccatc ccggccaacg ccaccaacgt gcccatctcc 21300

atcccctcgc gcaactgggc cgccttccgc ggatggtcct tcacgcgcct caagacccgc 21360

gagacgccct cgctcggctc cgggttcgac ccctacttcg tctactcggg ctccatcccc 21420

tacctcgacg gcaccttcta cctcaaccac accttcaaga aggtctccat caccttcgac 21480

tcctccgtca gctggcccgg caacgaccgc ctcctgacgc ccaacgagtt cgaaatcaag 21540

cgcaccgtcg acggagaggg atacaacgtg gcccagtgca acatgaccaa ggactggttc 21600

ctggtccaga tgctggccca ctacaacatc ggctaccagg gcttctacgt gcccgagggc 21660

tacaaggacc gcatgtactc cttcttccgc aacttccagc ccatgagccg ccaggtcgtg 21720

gacgaggtca actacaagga ctaccaggcc gtcaccctgg cctaccagca caacaactcg 21780

ggcttcgtcg gctacctcgc gcccaccatg cgccagggcc agccctaccc cgccaactac 21840

ccctacccgc tcatcggcaa gagcgccgtc gccagcgtca cccagaaaaa gttcctctgc 21900

gaccgggtca tgtggcgcat ccccttctcc agcaacttca tgtccatggg cgcgctcacc 21960

gacctcggcc agaacatgct ctacgccaac tccgcccacg cgctagacat gaatttcgaa 22020

gtcgacccca tggatgagtc cacccttctc tatgttgtct tcgaagtctt cgacgtcgtc 22080

cgagtgcacc agccccaccg cggcgtcatc gaggccgtct acctgcgcac gcccttctcg 22140

gccggcaacg ccaccaccta aagccccgct cttgcttctt gcaagatgac ggcctgtggc 22200

tccggcgagc aggagctcag ggccatcctc cgcgacctgg gctgcgggcc ctgcttcctg 22260

ggcaccttcg acaagcgctt cccgggattc atggccccgc acaagctggc ctgcgccatc 22320

gtcaacacgg ccggccgcga gaccgggggc gagcactggc tggccttcgc ctggaacccg 22380

cgctcccaca cctgctacct cttcgacccc ttcgggttct cggacgagcg cctcaagcag 22440

atctaccagt tcgagtacga gggcctgctg cgccgcagcg ccctggccac cgaggaccgc 22500

tgcatcaccc tggaaaagtc cacccagacc gtgcagggtc cgcgctcggc cgcctgcggg 22560

ctcttctgct gcatgttcct gcacgccttc gtgcactggc ccgaccgccc catggacaag 22620

aaccccacca tgaacttgct gacgggggtg cccaacggca tgctccagtc gccccaggtg 22680

gaacccaccc tgcgccgcaa ccaggaggcg ctctaccgct tcctcaacgc ccactccgcc 22740

tactttcgct cccaccgcgc gcgcatcgag aaggccaccg ccttcgaccg catgaatcaa 22800

gacatgtaaa ctgtgtgtat gtgaatgctt tattcatcat aataaacagc acatgtttat 22860

gccaccttct ctgaggctct gactttattt agaaatcgaa ggggttctgc cggctctcgg 22920

cgtgccccgc gggcagggat acgttgcgga actggtactt gggcagccac ttgaactcgg 22980

ggatcagcag cttcggcacg gggaggtcgg ggaacgagtc gctccacagc ttgcgcgtga 23040

gttgcagggc gcccagcagg tcgggcgcgg agatcttgaa atcgcagttg ggacccgcgt 23100

tctgcgcgcg agagttgcgg tacacggggt tgcagcactg gaacaccatc agggccgggt 23160

gcttcacgct cgccagcacc gtcgcgtcgg tgatgccctc cacgtccaga tcctcggcgt 23220

tggccatccc gaagggggtc atcttgcagg tctgccgccc catgctgggc acgcagccgg 23280

gcttgtggtt gcaatcgcag tgcaggggga tcagcatcat ctgagcctgc tcggagctca 23340

tgcccgggta catggccttc atgaaagcct ccagctggcg gaaggcctgc tgcgccttgc 23400

cgccctcggt gaagaagacc ccacaggact tgctagagaa ctggttggtg gcgcagcccg 23460

cgtcgtgcac gcagcagcgc gcgtcgttgt tggccagctg caccacgctg cgcccccagc 23520

ggttctgggt gatcttggcc cggtcggggt tctccttcag cgcgcgctgc ccgttctcgc 23580

tcgccacatc catctcgatc gtgtgctcct tctggatcat cacggtcccg tgcaggcacc 23640

gcagcttgcc ctcggcctcg gtgcacccgt gcagccacag cgcgcagccg gtgcactccc 23700

agttcttgtg ggcgatctgg gagtgcgagt gcacgaagcc ctgcaggaag cggcccatca 23760

tcgtggtcag ggtcttgttg ctggtgaagg tcagcgggat gccgcggtgc tcctcgttca 23820

catacaggtg gcagatgcgg cggtacacct cgccctgctc gggcatcagc tggaaggcgg 23880

acttcaggtc gctctccacg cggtaccgct ccatcagcag cgtcatcact tccatgccct 23940

tctcccaggc cgaaacgatc ggcaggctca gggggttctt caccgtcatc ttagtcgccg 24000

ccgccgaagt cagggggtcg ttctcgtcca gggtctcaaa cactcgcttg ccgtccttct 24060

cggtgatgcg cacggggggga aagctgaagc ccacggccgc cagctcctcc tcggcctgcc 24120

tttcgtcctc gctgtcctgg ctgatgtctt gcaaaggcac atgcttggtc ttgcggggtt 24180

tctttttggg cggcagaggc ggcggcggag acgtgctggg cgagcgcgag ttctcgctca 24240

ccacgactat ttcttcttct tggccgtcgt ccgagaccac gcggcggtag gcatgcctct 24300

tctggggcag aggcggaggc gacgggctct cgcggttcgg cgggcggctg gcagagcccc 24360

ttccgcgttc gggggtgcgc tcctggcggc gctgctctga ctgacttcct ccgcggccgg 24420

ccattgtgtt ctcctaggga gcaacaagca tggagactca gccatcgtcg ccaacatcgc 24480

catctgcccc cgccgccgac gagaaccagc agcagcagaa tgaaagctta accgccccgc 24540

cgcccagccc cacctccgac gccgccgcgg ccccagacat gcaagagatg gaggaatcca 24600

tcgagattga cctgggctac gtgacgcccg cggagcacga ggaggagctg gcagcgcgct 24660

tttcagcccc ggaagagaac caccaagagc agccagagca ggaagcagag agcgagcagc 24720

agcaggctgg gctcgagcat ggcgactacc tgagcggggc agaggacgtg ctcatcaagc 24780

atctggcccg ccaaagcatc atcgtcaagg acgcgctgct cgaccgcgcc gaggtgcccc 24840

tcagcgtggc ggagctcagc cgcgcctacg agcgcaacct cttctcgccg cgcgtgcccc 24900

ccaagcgcca gcccaacggc acctgcgagc ccaacccgcg cctcaacttc tacccggtct 24960

tcgcggtgcc cgaggccctg gccacctacc acctcttttt caagaaccaa aggatccccg 25020

tctcctgccg cgccaaccgc acccgcgccg acgccctgct caacctgggt cccggcgccc 25080

gcctacctga tatcacctcc ttggaagagg ttcccaagat cttcgagggt ctgggcagcg 25140

acgagactcg ggccgcgaac gctctgcaag gaagcggaga ggagcatgag caccacagcg 25200

ccctggtgga gttggaaggc gacaacgcgc gcctggcggt gctcaagcgc acggtcgagc 25260

tgacccactt cgcctacccg gcgctcaacc tgcccccccaa ggtcatgagc gccgtcatgg 25320

accaggtgct catcaagcgc gcctcgcccc tctcagagga ggagatgcag gaccccgaga 25380

gctcggacga gggcaagccc gtggtcagcg acgagcagct ggcgcgctgg ctgggagcga 25440

gcagcacccc ccagagcctg gaagagcggc gcaagctcat gatggccgtg gtcctggtga 25500

ccgtggagct ggagtgtctg cgccgcttct tcgccgacgc ggagaccctg cgcaaggtcg 25560

aggagaacct gcactacctc ttcaggcacg ggttcgtgcg ccaggcctgc aagatctcca 25620

acgtggagct gaccaacctg gtctcctaca tgggcatcct gcacgagaac cgcctggggc 25680

agaacgtgct gcacaccacc ctgcgcgggg aggcccgccg cgactacatc cgcgactgcg 25740

tctacctgta cctctgccac acctggcaga cgggcatggg cgtgtggcag cagtgcctgg 25800

aggagcagaa cctgaaagag ctctgcaagc tcctgcagaa gaacctcaag gccctgtgga 25860

ccgggttcga cgagcgcacc accgcctcgg acctggccga cctcatcttc cccgagcgcc 25920

tgcggctgac gctgcgcaac gggctgcccg actttatgag ccaaagcatg ttgcaaaact 25980

ttcgctcttt catcctcgaa cgctccggga tcctgcccgc cacctgctcc gcactgccct 26040

cggacttcgt gccgctgacc ttccgcgagt gccccccgcc gctctggagc cactgctact 26100

tgctgcgcct ggccaactac ctggcctacc actcggacgt gatcgaggac gtcagcagcg 26160

agggtctgct cgagtgccac tgccgctgca acctctgcac gccgcaccgc tccttggcct 26220

gcaaccccca gctgctgagc gagacccaga tcatcggcac cttcgagttg caaggccccg 26280

gcgagggcaa ggggggtctc aaactcaccc cggggctgtg gacctcggcc tacttgcgca 26340

agttcgtgcc cgaggactac catcccttcg agatcaggtt ctacgaggac caatcccagc 26400

cgcccaaggc cgagctgtcg gcctgcgtca tcacccaggg ggccatcctg gcccaattgc 26460

aagccatcca gaaatcccgc caagaatttc tgctgaaaaa gggccacggg gtctacttgg 26520

acccccagac cggagaggag ctcaacccca gcttccccca ggatgccccg aggaagcagc 26580

aagaagctga aagtggagct gccgctgccg ccggaggatt tggaggaaga ctgggagagc 26640

agtcaggcag aggagatgga agactgggac agcactcagg cagaggagga cagcctgcaa 26700

gacagtctgg aggaggaaga cgaggtggag gaggaggcag aggaagaagc agccgccgcc 26760

agaccgtcgt cctcggcgga ggagaaagca agcagcacgg ataccatctc cgctccgggt 26820

cggggtcgcg gcggccgggc ccacagtaga tgggacgaga ccgggcgctt cccgaacccc 26880

accacccaga ccggtaagaa ggagcggcag ggatacaagt cctggcgggg gcacaaaaac 26940

gccatcgtct cctgcttgca agcctgcggg ggcaacatct ccttcacccg gcgctacctg 27000

ctcttccacc gcggggtgaa cttccccccgc aacatcttgc attactaccg tcacctccac 27060

agcccctact actgtttcca agaagaggca gaaacccagc agcagcagca gaaaaccagc 27120

ggcagcagca gcagctagaa aatccacagc ggcggcaggt ggactgagga tcgcggcgaa 27180

cgagccggcg cagacccggg agctgaggaa ccggatcttt cccaccctct atgccatctt 27240

ccagcagagt cgggggcagg agcaggaact gaaagtcaag aaccgttctc tgcgctcgct 27300

cacccgcagt tgtctgtatc acaagagcga agaccaactt cagcgcactc tcgaggacgc 27360

cgaggctctc ttcaacaagt actgcgcgct cactcttaaa gagtagcccg cgcccgccca 27420

cacacggaaa aaggcgggaa ttacgtcacc acctgcgccc ttcgcccgac catcatcatg 27480

agcaaagaga ttcccacgcc ttacatgtgg agctaccagc cccagatggg cctggccgcc 27540

ggcgccgccc aggactactc cacccgcatg aactggctca gtgccgggcc cgcgatgatc 27600

tcacgggtga atgacatccg cgcccaccga aaccagatac tcctagaaca gtcagcgatc 27660

accgccacgc cccgccatca ccttaatccg cgtaattggc ccgccgccct ggtgtaccag 27720

gaaattcccc agcccacgac cgtactactt ccgcgagacg cccaggccga agtccagctg 27780

actaactcag gtgtccagct ggccggcggc gccgccctgt gtcgtcaccg ccccgctcag 27840

ggtataaagc ggctggtgat ccgaggcaga ggcacacagc tcaacgacga ggtggtgagc 27900

tcttcgctgg gtctgcgacc tgacggagtc ttccaactcg ccggatcggg gagatcttcc 27960

ttcacgcctc gtcaggccgt cctgactttg gagagttcgt cctcgcagcc ccgctcgggc 28020

ggcatcggca ctctccagtt cgtggaggag ttcactccct cggtctactt caaccccttc 28080

tccggctccc ccggccacta cccggacgag ttcatcccga acttcgacgc catcagcgag 28140

tcggtggacg gctacgattg aatgtcccat ggtggcgcgg ctgacctagc tcggcttcga 28200

cacctggacc actgccgccg cttccgctgc ttcgctcggg atctcgccga gtttgcctac 28260

tttgagctgc ccgaggagca ccctcagggc ccggcccacg gagtgcggat cgtcgtcgaa 28320

gggggcctcg actcccacct gcttcggatt ttcagccagc gtccgatcct ggtcgagcgc 28380

gagcaaggac agacccttct gaccctgtac tgcatctgca accaccccgg cctgcatgaa 28440

agtctttgtt gtctgctgtg tactgagtat aataaaagct gagatcagcg actactccgg 28500

actcgattgt ggtgttcctg ctatcaaccg gtccctgttc ttcaccggga acgagaccga 28560

gctccagctc cagtgtaagc cccacaagaa gtatctcacc tggctgttcc agggctctcc 28620

gatcgccgtt gtcaaccact gcgacaacga cggagtcctg ctgagcggcc ctgccaacct 28680

tactttttcc acccgcagaa gcaagctcca gctcttccaa cccttcctcc ccgggaccta 28740

tcagtgcgtc tcgggaccct gccatcacac cttccacctg atcccgaata ccacagcgcc 28800

gctccccgct actaacaacc aaactaccca ccaacgccac cgtcgcgacc tttctgaatc 28860

taatactacc acccacaccg gaggtgagct ccgaggtcga ccaacctctg ggatttacta 28920

cggggttaac cacgtggtta ctatgtcctt ccgagtgaga gacacaaaaa attccaacac 28980

actattgcaa tgaaaataaa tttcctttat tagccagaag tcagatgctc aaggggcttc 29040

atgatgtccc cataattttt ggcagaggga aaaagatctc catggcctag gtctagatta 29100

cttctgaccg ggctttttgc actcgaaggg gatgtcggtt aaaaaggtct ttaaagagtc 29160

gatgaagtcg gcgtaggtgg taacttgggt ctcgcaatct gtctcggggg tgggggggca 29220

gtaggtctgg tagtagctgg cggtcatgtt taaagcgccc ttcagcttgg tgaagttgcc 29280

cctcagacct tgctcgaaga tcttcagacg agtctgcaca caagtcagct tcttgaagct 29340

gaactcgttg ctcaccacct cgacctcctc atttaaagtc acgggcatgt cgtccagtaa 29400

atttaaagct tccttgatgg cctccacgtg cttccaagga cgagtcactg tgatagggga 29460

acgagtgggg gcgcttaaag agtacaccac gatgcctaaa aacagtaaat tctgcagcca 29520

catggtccta ggctgttcgt cacccaggac ctggctagcc tgcccagtgc ctcacgacca 29580

acttctgcag cttaagttcg agactgttgt gtcagaagca ctgactgcgt tagcaattta 29640

actgtgataa actaccgcaa taaagcttgc tcccgcccgc cgcgcgcttc gctttttata 29700

gggccgccgc cgccgccgcc tcgccataaa aggaaacttt cggagcgcgc cgctctgatt 29760

ggctgccgcc gcacctctcc gcctcgcccc gccccgcccc tcgccccgcc ccgccccgcc 29820

tggcgcgcgc cccccccccc cgcccccatc gctgcacaaa ataattaaaa aataaataaa 29880

tacaaaattg ggggtgggga ggggggggag atggggagag tgaagcagaa cgtggggatc 29940

cgcgatccat taattaaggg gattccatat ggtacgtaca tcgcctctcc tacgagctcc 30000

tgcagcagcg ccagaagttc acctgcctgg tcggagtcaa ccccatcgtc atcacccagc 30060

agtcgggcga taccaagggg tgcatccact gctcctgcga ctccccccgac tgcgtccaca 30120

ctctgatcaa gaccctctgc ggcctccgcg acctcctccc catgaactaa tcaccccctt 30180

atccagtgaa ataaagatca tattgatgat gattttacag aaataaagat acaatcatat 30240

tgatgatttg agtttaataa aaaataaaga atcacttact tgaaatctga taccaggtct 30300

ctgtccatgt tttctgccaa caccacttca ctcccctctt cccagctctg gtactgcagg 30360

ccccggcggg ctgcaaactt cctccacacg ctgaagggga tgtcaaattc ctcctgtccc 30420

tcaatcttca ttttatcttc tatcagatgt ccaaaaagcg cgtccgggtg gatgatgact 30480

tcgaccccgt ctacccctac gatgcagaca acgcaccgac cgtgcccttc atcaaccccc 30540

ccttcgtctc ttcagatgga ttccaagaga agcccctggg ggtgctgtcc ctgcgactgg 30600

ccgaccccgt caccaccaag aacggggaaa tcaccctcaa gctgggag ggggtggacc 30660

tcgactcctc gggaaaactc atctccaaca cggccaccaa ggccgccgcc cctctcagtt 30720

tttccaacaa caccatttcc cttaacatgg atcacccctt ttacactaaa gatggaaaat 30780

tatccttaca agtttctcca ccattaaata tactgagaac aagcattcta aacacactag 30840

ctttaggttt tggatcaggt ttaggactcc gtggctctgc cttggcagta cagttagtct 30900

ctccacttac atttgatact gatggaaaca taaagcttac cttagacaga ggtttgcatg 30960

ttacaacagg agatgcaatt gaaagcaaca taagctgggc taaaggttta aaatttgaag 31020

atggagccat agcaaccaac attggaaatg ggttagagtt tggaagcagt agtacagaaa 31080

caggtgttga tgatgcttac ccaatccaag ttaaacttgg atctggcctt agctttgaca 31140

gtacaggagc cataatggct ggtaacaaag aagacgataa actcactttg tggacaacac 31200

ctgatccatc gccaaactgt caaatactcg cagaaaatga tgcaaaacta acactttgct 31260

tgactaaatg tggtagtcaa atactggcca ctgtgtcagt cttagttgta ggaagtggaa 31320

acctaaaccc cattactggc accgtaagca gtgctcaggt gtttctacgt tttgatgcaa 31380

acggtgttct tttaacagaa cattctacac taaaaaaata ctgggggtat aggcagggag 31440

atagcataga tggcactcca tataccaatg ctgtaggatt catgcccaat ttaaaagctt 31500

atccaaagtc acaaagttct actactaaaa ataatatagt agggcaagta tacatgaatg 31560

gagatgtttc aaaacctatg cttctcacta taaccctcaa tggtactgat gacagcaaca 31620

gtacatattc aatgtcattt tcatacacct ggactaatgg aagctatgtt ggagcaacat 31680

ttggggctaa ctcttatacc ttctcataca tcgcccaaga atgaacactg tatcccaccc 31740

tgcatgccaa cccttcccac cccactctgt ggaaaaaact ctgaaacaca aaataaaata 31800

aagttcaagt gttttattga ttcaacagtt ttacaggatt cgagcagtta tttttcctcc 31860

accctcccag gacatggaat acaccaccct ctccccccgc acagccttga acatctgaac 31920

gccattggtg atggacatgc ttttggtctc cacgttccac acagtttcag agcgagccag 31980

tctcgggtcg gtcagggaga tgaaaccctc cgggcacaat tgggagaagt actcgcctat 32040

tatctggaag aagcagaaga gcggcggtgg gaatcatagt ccgcgaacgg gatcggccgg 32100

tggtgtcgca tcaggccccg cagcagtcgc tgccgccgcc gctccgtcaa gctgctgctc 32160

agggggtccg ggtccaggga ctccctcagc atgatgccca cggccctcag catcagtcgt 32220

ctggtgcggc gggcgcagca gcgcatgcgg atctcgctca ggtcgctgca gtacgtgcaa 32280

cacagaacca ccaggttgtt caacagtcca tagttcaaca cgctccagcc gaaactcatc 32340

gcgggaagga tgctacccac gtggccgtcg taccagatcc tcaggtaaat caagtggtgc 32400

cccctccaga acacgctgcc cacgtacatg atctccttgg gcatgtggcg gttcaccacc 32460

tcccggtacc acatcaccct ctggttgaac atgcagcccc ggatgatcct gcggaaccac 32520

agggccagca ccgccccgcc cgccatgcag cgaagagacc ccgggtcccg gcaatggcaa 32580

tggaggaccc accgctcgta cccgtggatc atctgggagc tgaacaagtc tatgttggca 32640

cagcacaggc atatgctcat gcatctcttc agcactctca actcctcggg ggtcaaaacc 32700

atatcccagg gcacgggggaa ctcttgcagg acagcgaacc ccgcagaaca gggcaatcct 32760

cgcacagaac ttacattgtg catggacagg gtatcgcaat caggcagcac cgggtgatcc 32820

tccaccagag aagcgcgggt ctcggtctcc tcacagcgtg gtaagggggc cggccgatac 32880

gggtgatggc gggacgcggc tgatcgtgtt cgcgaccgtg tcatgatgca gttgctttcg 32940

gacatatttc ctgaagtctt ggcgcgccaa agtctagaca gcgtccatag cttaccgagc 33000

agcagcagca gcacacaaca ggcgcaagag tcagagaaag gctgagctct aacctgtcca 33060

cccgctctct gctcaatata tagcccagat ctacactgac gtaaaggcca aagtctaaaa 33120

atacccgcca aatagtcaca cacgcccagc acacgcccag aaaccggtga cacactcaaa 33180

aaaatacgcg cacttcctca aacgcccaaa ctgccgtcat ttccgggttc ccacgctacg 33240

tcatcaaaac acgactttca aattccgtcg accgttaaaa acgtcacccg ccccgcccct 33300

aacggtcgcc cgtctctcag ccaatcagcg ccccgcatcc ccaaattcaa acacctcatt 33360

tgcatattaa cgcgcaccaa aagtttgagg tatattattg atgatgattt 33410

<210> 19

<211> 36962

<212> DNA

<213> Artificial Sequence

<400> 19

cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg 60

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca 120

gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt 180

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg 240

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct 300

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat 360

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc 420

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg 480

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg 540

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga 600

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta 660

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc 720

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc 780

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg 840

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc 900

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca 960

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct 1020

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat 1080

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg 1140

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat 1200

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact 1260

tcatttttaa tttaaaagga tctaggtgaa gatcctttttt gataatctca tgaccaaaat 1320

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc 1380

ttcttgagat ccttttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct 1440

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg 1500

cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca 1560

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc 1620

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga 1680

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac 1740

gacctacacc gaactgagat acctacagcg tgagctttga gatagcgcca cgcttcccga 1800

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag 1860

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg 1920

acttgagcgt cgattttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag 1980

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc 2040

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc 2100

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc 2160

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag 2220

gtttcccgac tggatttaaa tcatcatcaa taatatacct caaacttttg gtgcgcgtta 2280

atatgcaaat gaggtgtttg aatttgggga tgcggggcgc tgattggctg agagacgggc 2340

gaccgttagg ggcggggcgg gtgacgtttt gatgacgtgg ccgtgaggcg gagccggttt 2400

gcaagttctc gtgggaaaag tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca 2460

attttcccgc gctctctgac aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg 2520

gccattttcg cgcgaaaact gaatgaggaa gtgaaaatct gagtaattcc gcgtttatgg 2580

cagggaggag tatttgccga gggccgagta gactttgacc gattacgtgg gggtttcgat 2640

taccgtattt ttcacctaaa tttccgcgta cggtgtcaaa gtccggtgtt tttacgtagg 2700

cgtcagctga tcgccagggt atttaaacct gcgctctcta gtcaagaggc cactcttgag 2760

tgccagcgag tagagttttc tcctccgcgc cgcgagtcag atctacactt tgaaaggcga 2820

tcgccgatat catttccccg aaaagtgcca cctgaccgta actataacgg tcctaaggta 2880

gcgaaagctc agatctcccg atcccctatg gtgcactctc agtacaatct gctctgatgc 2940

cgcatagtta agccagtatc tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc 3000

gagcaaaatt taagctacaa caaggcaagg cttgaccgac aattgcatga agaatctgct 3060

tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc agatatacgc gttgacattg 3120

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat 3180

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc 3240

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca 3300

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta 3360

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta 3420

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat 3480

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga 3540

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca 3600

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg 3660

taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcac 3720

tagaagcttt attgcggtag tttatcacag ttaaattgct aacgcagtca gtgcttctga 3780

cacaacagtc tcgaacttaa gctgcagaag ttggtcgtga ggcactgggc aggtaagtat 3840

caaggttaca agacaggttt aaggagacca atagaaactg ggcttgtcga gacagagaag 3900

actcttgcgt ttctgatagg cacctattgg tcttactgac atccactttg cctttctctc 3960

cacaggtgtc cactcccagt tcaattacag ctcttaaggc tagagtactc tagcccggga 4020

tccaccggtc gccaccatgt ttcaggatcc ccaggagcgg ggccgcaagc tgccacagct 4080

gtgcacagag ctccagacaa ccattcacga tattattctc gagtgcgtct actgtaagca 4140

gcagctcctg cgccgggagg tctacgactt cgctagacgc gacctgtgta tcgtctaccg 4200

cgatggaaat ccatacgccg tcggcgataa gtgcctcaag ttttactcta agatttctga 4260

gtaccggcac tactgttact cactgtacgg aaccaccctc gagcagcagt acaataagcc 4320

tctgtgtgat ctgctcatta gatgcattaa tggccagaag cctctctgtc cagaggagaa 4380

gcagcggcac ctcgataaga agcagcggtt tcacaatact aggggaaggt ggaccggaag 4440

gtgtatgtca tgttgtcggt catcaagaac tagacgcgag acacagctca gaaagaggcg 4500

cgggtcaggc gcaccagtca agcagactct gaactttgat ctcctcaagc tcgctggcga 4560

cgtcgagtct aatcctggcc cccacggcga caccccaacc ctccacgagt acatgctgga 4620

tctccagccc gagacaaccg acctctacgg gtacgggcag ctcaatgatt catcagagga 4680

ggaggatgag attgatggcc ccgccggaca ggctgagccc gatagggccc actacaatat 4740

cgtgacattt tgttgcaagg gcgattcaac actccgcctg tgcgtgcagt caacccacgt 4800

ggatattcgg actctcgagg atctgctcat gggaacactg ggaattgtgt gccctatttg 4860

ttcccagaag cctagaaaga ggcgcgggtc cggcgcaaca aattttagcc tgctcaagca 4920

ggctggcgac gtcgaggaga atcctgggcc cgctaggttt gaggatccaa ctagacgcgg 4980

gtacaagctc cccgatctgt gtacagagct gaatacatca ctccaggata ttgagattac 5040

ttgcgtgtac tgtaagaccg tcctcgagct gactgaggtc tttgagttcg ctagaaagga 5100

tctcttcgtg gtctaccggg attctatccc acacgccgcc ggacacaagt gcattgactt 5160

ttactctcgc attagggagc tcaggcacta ctccgatagc gtctacgggg atacactgga 5220

gaagctgact aatactggac tgtacaatct gctcattaga tgcctgcgcg gacagaagcc 5280

tctcaatccc gctgagaagc tgcggcacct gaatgagaag agacggtttc acaataccgc 5340

cggacactac cggggccagt gtcactcttg ttgtaatagg gctaggcagg agcggctcca 5400

gagacgccgc gagactcagg tccgcaagag gcgcgggtcc ggcgcacccg tgaagcagac 5460

cctgaacttt gatctcctga agctcgctgg ggacgtggag tctaaccctg ggccacacgg 5520

accaaaggct accctccagg atatcgtcct gcacctcgag ccacagaatg agattcccgt 5580

cgacctgctc ggccacggac agctgtccga tagcgaggag gagaacgatg agattgatgg 5640

ggtgaatcac cagcacctgc ccgctagacg cgccgagcca cagcggcaca ccatgctgtg 5700

tatgtgttgc aagggggagg cacgcatcga gctggtggtg gagtcttccg ccgatgacct 5760

cagggctttt cagcagctct ttctgaatac cctgtccttc gtgtgccctt ggtgcgcttc 5820

ccagcagtga agcggccgcc actgtgctgg atgatccgag ctcggtacct ctagagtcga 5880

cccgggcggc caaaccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt 5940

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc 6000

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt 6060

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat 6120

gcggtgggct ctatggcttc tgaggcggaa agaaccagca gatctgcaga tctgaattca 6180

tctatgtcgg gtgcggagaa agaggtaatg aaatggcatt atgggtatta tgggtctgca 6240

ttaatgaatc ggccagatat cgacatatgc tggccaccgt acatgtggct tcccatgctc 6300

gcaagccctg gcccgagttc gagcacaatg tcatgaccag gtgcaatatg catctggggt 6360

cccggcgatc gcccgaggca tgttcatgcc ctaccagtgc aacatgcaat ttgtgaaggt 6420

gctgctggag cccgatgcca tgtccagagt gagcctgacg ggggtgtttg acatgaatgt 6480

ggagctgtgg aaaattctga gatatgatga atccaagacc aggtgccggg cctgcgaatg 6540

cggaggcaag cacgccaggc ttcagcccgt gtgtgtggag gtgacggagg acctgcgacc 6600

cgatcatttg gtgttgtcct gcaacgggac ggagttcggc tccagcgggg aagaatctga 6660

ctagagtgag tagtgtttgg gggtgggtgg gagcctgcat gatgggcaga atgactaaaa 6720

tctgtgtttt tctgtgtgtt gcagcagcat gagcggaagc gcctcctttg agggaggggt 6780

attcagccct tatctgacgg ggcgtctccc ctcctgggcg ggagtgcgtc agaatgtgat 6840

gggatccacg gtggacggcc ggcccgtgca gcccgcgaac tcttcaaccc tgacctacgc 6900

gaccctgagc tcctcgtccg tggacgcagc tgccgccgca gctgctgctt ccgccgccag 6960

cgccgtgcgc ggaatggccc tgggcgccgg ctactacagc tctctggtgg ccaactcgag 7020

ttccaccaat aatcccgcca gcctgaacga ggagaagctg ttgctgctga tggcccagct 7080

cgaggccctg acccagcgcc tgggcgagct gacccagcag gtggctcagc tgcaggcgga 7140

gacgcgggcc gcggttgcca cggtgaaaac caaataaaaa atgaatcaat aaataaacgg 7200

agacggttgt tgattttaac acagagtctt gaatctttat ttgattttttc gcgcgcggta 7260

ggccctggac caccggtctc gatcattgag cacccggtgg atcttttcca ggacccggta 7320

gaggtgggct tggatgttga ggtacatggg catgagcccg tcccgggggt ggaggtagct 7380

ccattgcagg gcctcgtgct cgggggtggt gttgtaaatc acccagtcat agcaggggcg 7440

cagggcgtgg tgctgcacga tgtctttgag gaggagactg atggccacgg gcagcccctt 7500

ggtgtaggtg ttgacgaacc tattgagctg ggagggatgc atgcgggggg agatgagatg 7560

catcttggcc tggatcttga gattggcgat gttcccgccc agatcccgcc gggggttcat 7620

gttgtgcagg accaccagca cggtgtatcc ggtgcacttg gggaatttgt catgcaactt 7680

ggaagggaag gcgtgaaaga atttggagac gcccttgtga ccgcccaggt tttccatgca 7740

ctcatccatg atgatggcga tgggcccgtg ggcggcggcc tgggcaaaga cgtttcgggg 7800

gtcggacaca tcgtagttgt ggtcctgggt gagctcgtca taggccattt taatgaattt 7860

ggggcggagg gtacccgact gggggacaaa ggtgccctcg atcccggggg cgtagttccc 7920

ctcgcagatc tgcatctccc aggccttgag ctcggagggg gggatcatgt ccacctgcgg 7980

ggcgatgaaa aaaacggttt ccggggcggg ggagatgagc tgcgccgaaa gcaggttccg 8040

gagcagctgg gacttgccgc agccggtggg gccgtagatg accccgatga ccggctgcag 8100

gtggtagttg agggagagac agctgccgtc ctcgcggagg aggggggcca cctcgttcat 8160

catctcgcgc acatgcatgt tctcgcgcac gagttccgcc aggaggcgct cgccccccag 8220

cgagaggagc tcttgcagcg aggcgaagtt tttcagcggc ttgagcccgt cggccatggg 8280

cattttggag agggtctgtt gcaagagttc cagacggtcc cagagctcgg tgatgtgctc 8340

tagggcatct cgatccagca gacctcctcg tttcgcgggt tggggcgact gcgggagtag 8400

ggcaccaggc gatgggcgtc cagcgaggcc agggtccggt ccttccaggg tcgcagggtc 8460

cgcgtcagcg tggtctccgt cacggtgaag gggtgcgcgc cgggctgggc gcttgcgagg 8520

gtgcgcttca ggctcatccg gctggtcgag aaccgctccc ggtcggcgcc ctgcgcgtcg 8580

gccaggtagc aattgagcat gagttcgtag ttgagcgcct cggccgcgtg gcccttggcg 8640

cggagcttac ctttggaagt gtgtccgcag acgggacaga ggagggactt gagggcgtag 8700

agcttggggg cgaggaagac ggactcgggg gcgtaggcgt ccgcgccgca gctggcgcag 8760

acggtctcgc actccacgag ccaggtgagg tcggggcggt cggggtcaaa aacgaggttt 8820

cctccgtgct ttttgatgcg tttcttacct ctggtctcca tgagctcgtg tccccgctgg 8880

gtgacaaaga ggctgtccgt gtccccgtag accgacttta tgggccggtc ctcgagcggg 8940

gtgccgcggt cctcgtcgta gaggaacccc gcccactccg agacgaaggc ccgggtccag 9000

gccagcacga aggaggccac gtgggagggg tagcggtcgt tgtccaccag cgggtccacc 9060

ttctccaggg tatgcaagca catgtccccc tcgtccacat ccaggaaggt gattggcttg 9120

taagtgtagg ccacgtgacc gggggtcccg gccgggggggg tataaaaggg ggcgggcccc 9180

tgctcgtcct cactgtcttc cggatcgctg tccaggagcg ccagctgttg gggtaggtat 9240

tccctctcga aggcgggcat gacctcggca ctcaggttgt cagtttctag aaacgaggag 9300

gatttgatat tgacggtgcc gttggagacg cctttcatga gcccctcgtc catctggtca 9360

gaaaagacga tctttttgtt gtcgagcttg gtggcgaagg agccgtagag ggcgttggag 9420

agcagcttgg cgatggagcg catggtctgg ttcttttcct tgtcggcgcg ctccttggcg 9480

gcgatgttga gctgcacgta ctcgcgcgcc acgcacttcc attcggggaa gacggtggtg 9540

agctcgtcgg gcacgattct gacccgccag ccgcggttgt gcagggtgat gaggtccacg 9600

ctggtggcca cctcgccgcg caggggctcg ttggtccagc agaggcgccc gcccttgcgc 9660

gagcagaagg ggggcagcgg gtccagcatg agctcgtcgg gggggtcggc gtccacggtg 9720

aagatgccgg gcaggagctc ggggtcgaag tagctgatgc aggtgcccag atcgtccaga 9780

cttgcttgcc agtcgcgcac ggccagcgcg cgctcgtagg ggctgagggg cgtgccccag 9840

ggcatggggt gcgtgagcgc ggaggcgtac atgccgcaga tgtcgtagac gtagaggggc 9900

tcctggagga cgccgatgta ggtggggtag cagcgccccc cgcggatgct ggcgcgcacg 9960

tagtcgtaca gctcgtgcga gggcgcgagg agccccgtgc cgagattgga gcgctgcggc 10020

ttttcggcgc ggtagacgat ctggcggaag atggcgtggg agttggagga gatggtgggc 10080

ctctggaaga tgttgaagtg ggcatggggc agtccgaccg agtccctgat gaagtgggcg 10140

taggagtcct gcagcttggc gacgagctcg gcggtgacga ggacgtccag ggcgcagtag 10200

tcgagggtct cttggatgat gtcgtacttg agctggccct tctgcttcca cagctcgcgg 10260

ttgagaagga actcttcgcg gtccttccag tactcttcga gggggaaccc gtcctgatcg 10320

gcacggtaag agcccaccat gtagaactgg ttgacggcct tgtaggcgca gcagcccttc 10380

tccacgggga gggcgtaagc ttgcgcggcc ttgcgcaggg aggtgtgggt gagggcgaag 10440

gtgtcgcgca ccatgacttt gaggaactgg tgcttgaagt cgaggtcgtc gcagccgccc 10500

tgctcccaga gctggaagtc cgtgcgcttc ttgtaggcgg ggttgggcaa agcgaaagta 10560

acatcgttga agaggatctt gcccgcgcgg ggcatgaagt tgcgagtgat gcggaaaggc 10620

tggggcacct cggcccggtt gttgatgacc tgggcggcga ggacgatctc gtcgaagccg 10680

ttgatgttgt gcccgacgat gtagagttcc acgaatcgcg ggcggccctt gacgtggggc 10740

agcttcttga gctcgtcgta ggtgagctcg gcggggtcgc tgagcccgtg ctgctcgagg 10800

gcccagtcgg cgacgtgggg gttggcgctg aggaaggaag tccagagatc cacggccagg 10860

gcggtctgca agcggtcccg gtactgacgg aactgctggc ccacggccat tttttcgggg 10920

gtgacgcagt agaaggtgcg ggggtcgccg tgccagcggt cccacttgag ctggagggcg 10980

aggtcgtggg cgagctcgac gagcggcggg tccccggaga gtttcatgac cagcatgaag 11040

gggacgagct gcttgccgaa ggaccccatc caggtgtagg tttccacatc gtaggtgagg 11100

aagagccttt cggtgcgagg atgcgagccg atggggaaga actggatctc ctgccaccag 11160

ttggaggaat ggctgttgat gtgatggaag tagaaatgcc gacggcgcgc cgagcactcg 11220

tgcttgtgtt tatacaagcg tccgcagtgc tcgcaacgct gcacgggatg cacgtgctgc 11280

acgagctgta cctgggttcc tttgacgagg aatttcagtg ggcagtggag cgctggcggc 11340

tgcatctggt gctgtactac gtcctggcca tcggcgtggc catcgtctgc ctcgatggtg 11400

gtcatgctga cgagcccgcg cgggaggcag gtccagacct cggctcggac gggtcggaga 11460

gcgaggacga gggcgcgcag gccggagctg tccagggtcc tgagacgctg cggagtcagg 11520

tcagtgggca gcggcggcgc gcggttgact tgcaggagct tttccagggc gcgcgggagg 11580

tccagatggt acttgatctc cacggcgccg ttggtggcga cgtccacggc ttgcagggtc 11640

ccgtgcccct ggggcgccac caccgtgccc cgtttcttct tgggcggcgg cggctccatg 11700

cttagaagcg gcggcgagga cgcgcgccgg gcggcagggg cggctcgggg cccggaggca 11760

ggggcggcag gggcacgtcg gcgccgcgcg cgggcaggtt ctggtactgc gcccggagaa 11820

gactggcgtg agcgacgacg cgacggttga cgtcctggat ctgacgcctc tgggtgaagg 11880

ccacgggacc cgtgagtttg aacctgaaag agagttcgac agaatcaatc tcggtatcgt 11940

tgacggcggc ctgccgcagg atctcttgca cgtcgcccga gttgtcctgg taggcgatct 12000

cggtcatgaa ctgctcgatc tcctcctcct gaaggtctcc gcggccggcg cgctcgacgg 12060

tggccgcgag gtcgttggag atgcggccca tgagctgcga gaaggcgttc atgccggcct 12120

cgttccagac gcggctgtag accacggctc cgtcggggtc gcgcgcgcgc atgaccacct 12180

gggcgaggtt gagctcgacg tggcgcgtga agaccgcgta gttgcagagg cgctggtaga 12240

ggtagttgag cgtggtggcg atgtgctcgg tgacgaagaa gtacatgatc cagcggcgga 12300

gcggcatctc gctgacgtcg cccagggctt ccaagcgctc catggcctcg tagaagtcca 12360

cggcgaagtt gaaaaactgg gagttgcgcg ccgagacggt caactcctcc tccagaagac 12420

ggatgagctc ggcgatggtg gcgcgcacct cgcgctcgaa ggccccgggg ggctcctctt 12480

ccatttcctc ctcttcctcc tccactaaca tctcttctac ttcctcctca ggaggcggcg 12540

gcgggggagg ggccctgcgt cgccggcggc gcacgggcag acggtcgatg aagcgctcga 12600

tggtctcccc gcgccggcga cgcatggtct cggtgacggc gcgcccgtcc tcgcggggcc 12660

gcagcgtgaa gacgccgccg cgcatctcca ggtggccgcc gggggggtct ccgttgggca 12720

gggagagggc gctgacgatg catcttatca attgacccgt agggactccg cgcaaggacc 12780

tgagcgtctc gagatccacg ggatccgaaa accgctgaac gaaggcttcg agccagtcgc 12840

agtcgcaagg taggctgagc ccggtttctt gttcttcggg tatttggtcg ggaggcgggc 12900

gggcgatgct gctggtgatg aagttgaagt aggcggtcct gagacggcgg atggtggcga 12960

ggagcaccag gtccttgggc ccggcttgct ggatgcgcag acggtcggcc atgccccagg 13020

cgtggtcctg acacctggcg aggtccttgt agtagtcctg catgagccgc tccacgggca 13080

cctcctcctc gcccgcgcgg ccgtgcatgc gcgtgagccc gaacccgcgc tgcggctgga 13140

cgagcgccag gtcggcgacg acgcgctcgg cgaggatggc ctgctggatc tgggtgaggg 13200

tggtctggaa gtcgtcgaag tcgacgaagc ggtggtaggc tccggtgttg atggtgtagg 13260

agcagttggc catgacggac cagttgacgg tctggtggcc ggggcgcacg agctcgtggt 13320

acttgaggcg cgagtaggcg cgcgtgtcga agatgtagtc gttgcaggtg cgcacgaggt 13380

actggtatcc gacgaggaag tgcggcggcg gctggcggta gagcggccat cgctcggtgg 13440

cgggggcgcc gggcgcgagg tcctcgagca tgaggcggtg gtagccgtag atgtacctgg 13500

acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg gaactcgcgg acgcggttcc 13560

agatgttgcg cagcggcagg aagtagttca tggtggccgc ggtctggccc gtgaggcgcg 13620

cgcagtcgtg gatgctctag acatacgggc aaaaacgaaa gcggtcagcg gctcgactcc 13680

gtggcctgga ggctaagcga acgggttggg ctgcgcgtgt accccggttc gaatctcgaa 13740

tcaggctgga gccgcagcta acgtggtact ggcactcccg tctcgaccca agcctgctaa 13800

cgaaacctcc aggatacgga ggcgggtcgt tttttggcct tggtcgctgg tcatgaaaaa 13860

ctagtaagcg cggaaagcgg ccgcccgcga tggctcgctg ccgtagtctg gagaaagaat 13920

cgccagggtt gcgttgcggt gtgccccggt tcgagcctca gcgctcggcg ccggccggat 13980

tccgcggcta acgtgggcgt ggctgccccg tcgtttccaa gaccccttag ccagccgact 14040

tctccagtta cggagcgagc ccctcttttt ttcttgtgtt tttgccagat gcatcccgta 14100

ctgcggcaga tgcgccccca ccctccacca caaccgcccc taccgcagca gcagcaacag 14160

ccggcgcttc tgcccccgcc ccagcagcag cagccagcca ctaccgcggc ggccgccgtg 14220

agcggagccg gcgttcagta tgacctggcc ttggaagagg gcgaggggct ggcgcggctg 14280

ggggcgtcgt cgccggagcg gcacccgcgc gtgcagatga aaagggacgc tcgcgaggcc 14340

tacgtgccca agcagaacct gttcagagac aggagcggcg aggagcccga ggagatgcgc 14400

gcctcccgct tccacgcggg gcgggagctg cggcgcggcc tggaccgaaa gcgggtgctg 14460

agggacgagg atttcgaggc ggacgagctg acggggatca gccccgcgcg cgcgcacgtg 14520

gccgcggcca acctggtcac ggcgtacgag cagaccgtga aggaggagag caacttccaa 14580

aaatccttca acaaccacgt gcgcacgctg atcgcgcgcg aggaggtgac cctgggcctg 14640

atgcacctgt gggacctgct ggaggccatc gtgcagaacc ccacgagcaa gccgctgacg 14700

gcgcagctgt ttctggtggt gcagcacagt cgggacaacg agacgttcag ggaggcgctg 14760

ctgaatatca ccgagcccga gggccgctgg ctcctggacc tggtgaacat tctgcagagc 14820

atcgtggtgc aggagcgcgg gctgccgctg tccgagaagc tggcggccat caacttctcg 14880

gtgctgagcc tgggcaagta ctacgctagg aagatctaca agaccccgta cgtgcccata 14940

gacaaggagg tgaagatcga tgggttttac atgcgcatga ccctgaaagt gctgaccctg 15000

agcgacgatc tgggggtgta ccgcaacgac aggatgcacc gcgcggtgag cgccagccgc 15060

cggcgcgagc tgagcgacca ggagctgatg cacagcctgc agcgggccct gaccggggcc 15120

gggaccgagg gggagagcta ctttgacatg ggcgcggacc tgcgctggca gcccagccgc 15180

cgggccttgg aagctgccgg cggcgtgccc tacgtggagg aggtggacga tgaggaggag 15240

gagggcgagt acctggaaga ctgatggcgc gaccgtattt ttgctagatg cagcaacagc 15300

caccgccgcc gcctcctgat cccgcgatgc gggcggcgct gcagagccag ccgtccggca 15360

ttaactcctc ggacgattgg acccaggcca tgcaacgcat catggcgctg acgacccgca 15420

atcccgaagc ctttagacag cagcctcagg ccaaccggct ctcggccatc ctggaggccg 15480

tggtgccctc gcgctcgaac cccacgcacg agaaggtgct ggccatcgtg aacgcgctgg 15540

tggagaacaa ggccatccgc ggcgacgagg ccgggctggt gtacaacgcg ctgctggagc 15600

gcgtggcccg ctacaacagc accaacgtgc agacgaacct ggaccgcatg gtgaccgacg 15660

tgcgcgaggc ggtgtcgcag cgcgagcggt tccaccgcga gtcgaacctg ggctccatgg 15720

tggcgctgaa cgccttcctg agcacgcagc ccgccaacgt gccccggggc caggaggact 15780

acaccaactt catcagcgcg ctgcggctga tggtggccga ggtgccccag agcgaggtgt 15840

accagtcggg gccggactac ttcttccaga ccagtcgcca gggcttgcag accgtgaacc 15900

tgagccaggc tttcaagaac ttgcagggac tgtggggcgt gcaggccccg gtcggggacc 15960

gcgcgacggt gtcgagcctg ctgacgccga actcgcgcct gctgctgctg ctggtggcgc 16020

ccttcacgga cagcggcagc gtgagccgcg actcgtacct gggctacctg cttaacctgt 16080

accgcgaggc catcgggcag gcgcacgtgg acgagcagac ctaccaggag atcacccacg 16140

tgagccgcgc gctgggccag gaggacccgg gcaacctgga ggccaccctg aacttcctgc 16200

tgaccaaccg gtcgcagaag atcccgcccc agtacgcgct gagcaccgag gaggagcgca 16260

tcctgcgcta cgtgcagcag agcgtggggc tgttcttgat gcaggagggg gccacgccca 16320

gcgccgcgct cgacatgacc gcgcgcaaca tggagcccag catgtacgcc cgcaaccgcc 16380

cgttcatcaa taagctgatg gactacttgc atcgggcggc cgccatgaac tcggactact 16440

ttaccaacgc catcttgaac ccgcactggc tcccgccgcc cgggttctac acgggcgagt 16500

acgacatgcc cgaccccaac gacgggttcc tgtgggacga cgtggacagc agcgtgttct 16560

cgccgcggcc caccaccacc accgtgtgga agaaagaggg cggggaccgg cggccgtcct 16620

cggcgctgtc cggtcgcgcg ggtgctgccg cggcggtgcc cgaggctgcc agccccttcc 16680

cgagcctgcc cttttcgctg aacagcgtgc gcagcagcga gctgggtcgg ctgacgcggc 16740

cgcgcctgct gggcgaggag gagtacctga acgactcctt gttgaagccc gagcgcgaga 16800

agaacttccc caataacggg atagagagcc tggtggacaa gatgagccgc tggaagacgt 16860

acgcgcacga gcacagggac gagccccgag ctagcagcgc aggcacccgt agacgccagc 16920

ggcacgacag gcagcgggga ctggtgtggg acgatgagga ttccgccgac gacagcagcg 16980

tgttggactt gggtgggagt ggtggtggta acccgttcgc tcacctgcgc ccccgtatcg 17040

ggcgcctgat gtaagaatct gaaaaaataa aagacggtac tcaccaaggc catggcgacc 17100

agcgtgcgtt cttctctgtt gtttgtagta gtatgatgag gcgcgtgtac ccggagggtc 17160

ctcctccctc gtacgagagc gtgatgcagc aggcggtggc ggcggcgatg cagcccccgc 17220

tggaggcgcc ttacgtgccc ccgcggtacc tggcgcctac ggaggggcgg aacagcattc 17280

gttactcgga gctggcaccc ttgtacgata ccacccggtt gtacctggtg gacaacaagt 17340

cggcggacat cgcctcgctg aactaccaga acgaccacag caacttcctg accaccgtgg 17400

tgcagaacaa cgatttcacc cccacggagg ccagcaccca gaccatcaac tttgacgagc 17460

gctcgcggtg gggcggccag ctgaaaacca tcatgcacac caacatgccc aacgtgaacg 17520

agttcatgta cagcaacaag ttcaaggcgc gggtgatggt ctcgcgcaag acccccaacg 17580

gggtcacggt aggggatgat tatgatggta gtcaggacga gctgacctac gagtgggtgg 17640

agtttgagct gcccgagggc aacttctcgg tgaccatgac catcgatctg atgaacaacg 17700

ccatcatcga caactacttg gcggtggggc ggcagaacgg ggtgctggag agcgacatcg 17760

gcgtgaagtt cgacacgcgc aacttccggc tgggctggga ccccgtgacc gagctggtga 17820

tgccgggcgt gtacaccaac gaggccttcc accccgacat cgtcctgctg cccggctgcg 17880

gcgtggactt caccgagagc cgcctcagca acctgctggg catccgcaag cggcagccct 17940

tccaggaggg cttccagatc ctgtacgagg acctggaggg gggcaacatc cccgcgctct 18000

tggatgtcga agcctatgaa gaaagtaagg aaaaagcaga ggctgaggca actacagccg 18060

tggctaccgc cgcgactgtg gcagatgcca ctgtcaccag gggcgataca ttcgccaccc 18120

aggcggagga agcagccgcc ctagcggcga ccgatgatag tgaaagtaag atagtcatca 18180

agccggtgga gaaggacagc aagaacagga gctacaacgt tctaccggat ggaaagaaca 18240

ccgcctaccg cagctggtac ctggcctaca actacggcga ccccgagaag ggcgtgcgct 18300

cctggacgct gctcaccacc tcggacgtca cctgcggcgt ggagcaagtc tactggtcgc 18360

tgcccgacat gatgcaagac ccggtcacct tccgctccac gcgacaagtt agcaactacc 18420

cggtggtggg cgccgagctc ctgcccgtct actccaagag cttcttcaac gagcaggccg 18480

tctactcgca gcagctgcgt gccttcacct cgctcacgca cgtcttcaac cgcttccccg 18540

agaaccagat cctcgtccgc ccgcccgcgc ccaccattac caccgtcagt gaaaacgttc 18600

ctgctctcac agatcacggg accctgccgc tgcgcagcag tatccgggga gtccagcgcg 18660

tgaccgtcac tgacgccaga cgccgcacct gcccctacgt ctacaaggcc ctgggcgtag 18720

tcgcgccgcg cgtcctctcg agccgcacct tctaaaaaat gtccattctc atctcgccca 18780

gtaataacac cggttggggc ctgcgcgcgc ccagcaagat gtacggaggc gctcgccaac 18840

gctccacgca acaccccgtg cgcgtgcgcg ggcacttccg cgctccctgg ggcgccctca 18900

agggccgcgt gcgctcgcgc accaccgtcg acgacgtgat cgaccaggtg gtggccgacg 18960

cgcgcaacta cacgcccgcc gccgcgcccg cctccaccgt ggacgccgtc atcgacagcg 19020

tggtggccga cgcgcgccgg tacgcccgcg ccaagagccg gcggcggcgc atcgcccggc 19080

ggcaccggag cacccccgcc atgcgcgcgg cgcgagcctt gctgcgcagg gccaggcgca 19140

cgggacgcag ggccatgctc agggcggcca gacgcgcggc ctccggcagc agcagcgccg 19200

gcaggacccg cagacgcgcg gccacggcgg cggcggcggc catcgccagc atgtcccgcc 19260

cgcggcgcgg caacgtgtac tgggtgcgcg acgccgccac cggtgtgcgc gtgcccgtgc 19320

gcacccgccc ccctcgcact tgaagatgct gacttcgcga tgttgatgtg tcccagcggc 19380

gaggaggatg tccaagcgca aatacaagga agagatgctc caggtcatcg cgcctgagat 19440

ctacggcccc gcggcggcgg tgaaggagga aagaaagccc cgcaaactga agcgggtcaa 19500

aaaggacaaa aaggaggagg aagatgacgg actggtggag tttgtgcgcg agttcgcccc 19560

ccggcggcgc gtgcagtggc gcgggcggaa agtgaaaccg gtgctgcggc ccggcaccac 19620

ggtggtcttc acgcccggcg agcgttccgg ctccgcctcc aagcgctcct acgacgaggt 19680

gtacggggac gaggacatcc tcgagcaggc ggtcgagcgt ctgggcgagt ttgcttacgg 19740

caagcgcagc cgccccgcgc ccttgaaaga ggaggcggtg tccatcccgc tggaccacgg 19800

caaccccacg ccgagcctga agccggtgac cctgcagcag gtgctgccga gcgcggcgcc 19860

gcgccggggc ttcaagcgcg agggcggcga ggatctgtac ccgaccatgc agctgatggt 19920

gcccaagcgc cagaagctgg aggacgtgct ggagcacatg aaggtggacc ccgaggtgca 19980

gcccgaggtc aaggtgcggc ccatcaagca ggtggccccg ggcctgggcg tgcagaccgt 20040

ggacatcaag atccccacgg agcccatgga aacgcagacc gagcccgtga agcccagcac 20100

cagcaccatg gaggtgcaga cggatccctg gatgccagcg gcttccacca ccaccactcg 20160

ccgaagacgc aagtacggcg cggccagcct gctgatgccc aactacgcgc tgcatccttc 20220

catcatcccc acgccgggct accgcggcac gcgcttctac cgcggctaca ccagcagccg 20280

ccgccgcaag accaccaccc gccgccgtcg tcgcagccgc cgcagcagca ccgcgacttc 20340

cgccttggtg cggagagtgt atcgcagcgg gcgcgagcct ctgaccctgc cgcgcgcgcg 20400

ctaccacccg agcatcgcca tttaactacc gcctcctact tgcagatatg gccctcacat 20460

gccgcctccg cgtccccatt acgggctacc gaggaagaaa gccgcgccgt agaaggctga 20520

cggggaacgg gctgcgtcgc catcaccacc ggcggcggcg cgccatcagc aagcggttgg 20580

ggggaggctt cctgcccgcg ctgatcccca tcatcgccgc ggcgatcggg gcgatccccg 20640

gcatagcttc cgtggcggtg caggcctctc agcgccactg agaacacaaaa aagcatggat 20700

ttgtaataaa aaaatggact gacgctcctg gtcctgtgat gtgtgttttt agatggaaga 20760

catcaatttt tcgtccctgg caccgcgaca cggcacgcgg ccgtttatgg gcacctggag 20820

cgacatcggc aacagccaac tgaacggggg cgccttcaat tggagcagtc tctggagcgg 20880

gcttaagaat ttcgggtcca cgctcaaaac ctatggcaac aaggcgtgga acagcagcac 20940

agggcaggcg ctgagggaaa agctgaaaga gcagaacttc cagcagaagg tggtcgatgg 21000

cctggcctcg ggcatcaacg gggtggtgga cctggccaac caggccgtgc agaaacagat 21060

caacagccgc ctggacgcgg tcccgcccgc ggggtccgtg gagatgcccc aggtggagga 21120

ggagctgcct cccctggaca agcgcggcga caagcgaccg cgtcccgacg cggaggac 21180

gctgctgacg cacacggacg agccgccccc gtacgaggag gcggtgaaac tgggtctgcc 21240

caccacgcgg cccgtggcgc ctctggccac cggggtgctg aaacccagca gcagcagcca 21300

gcccgcgacc ctggacttgc ctccgcctgc ttcccgcccc tccacagtgg ctaagcccct 21360

gccgccggtg gccgtcgcgt cgcgcgcccc ccgaggccgc ccccaggcga actggcagag 21420

cactctgaac agcatcgtgg gtctgggagt gcagagtgtg aagcgccgcc gctgctatta 21480

aaagacactg tagcgcttaa cttgcttgtc tgtgtgtgta tatgtatgtc cgccgaccag 21540

aaggaggaag aggcgcgtcg ccgagttgca agatggccac cccatcgatg ctgccccagt 21600

gggcgtacat gcacatcgcc ggacaggacg cttcggagta cctgagtccg ggtctggtgc 21660

agttcgcccg cgccacagac acctacttca gtctggggaa caagtttagg aaccccacgg 21720

tggcgcccac gcacgatgtg accaccgacc gcagccagcg gctgacgctg cgcttcgtgc 21780

ccgtggaccg cgaggacaac acctactcgt acaaagtgcg ctacacgctg gccgtgggcg 21840

acaaccgcgt gctggacatg gccagcacct actttgacat ccgcggcgtg ctggatcggg 21900

gccccagctt caaaccctac tccggcaccg cctacaacag cctagctccc aagggagcgc 21960

ccaacacctc acagtggaag gattccgaca gcaaaatgca tacttttgga gttgctgcca 22020

tgcccggtgt tgttggtaaa aaaatagaag ccgatggtct gcctattgga atagattcat 22080

cctctggaac tgacaccata atttatgctg ataaaacttt ccaaccagag ccacaggttg 22140

gaagtgacag ttgggtcgac accaatggtg cagaggaaaa atatggaggt agagctctta 22200

aggacactac aaacatgaag ccctgctacg gttcttttgc caggcctacc aacaaagaag 22260

gtggacaggc taacataaaa gattctgaaa ctgccagcac tactcctaac tatgatatag 22320

atttggcatt ctttgacagc aaaaatattg cagctaacta cgatccagat attgtaatgt 22380

acacagaaaa tgttgagttg caaactccag atactcatat tgtgtttaag ccaggaactt 22440

cagatgaaag ttcagaagcc aatttgggcc agcaggccat gcccaacaga cccaactaca 22500

tcgggttcag agacaacttt atcgggctca tgtactacaa cagcactggc aatatgggtg 22560

tactggctgg tcaggcctcc cagctaaatg ctgtggtgga cttgcaggac agaaacaccg 22620

aactgtccta ccagctcttg cttgactctc tgggtgacag aaccaggtat ttcagtatgt 22680

ggaatcaggc ggtggacagc tatgaccccg atgtgcgcat tattgaaaat cacggtgtgg 22740

aggatgaact ccccaattat tgcttccctt tgaatggtgt aggctttaca gatacttacc 22800

agggtgttaa agttaagaca gatacagccg ctactggtac caatggaacg cagtgggaca 22860

aagatgatac cacagtcagc actgccaatg agatccactc aggcaatcct ttcgccatgg 22920

agatcaacat ccaggccaac ctgtggcgga acttcctcta cgcgaacgtg gcgctgtacc 22980

tgcccgactc ctacaagtac acgccggcca acatcacgct gccgaccaac accaacacct 23040

acgattacat gaacggccgc gtggtggcgc cctcgctggt ggacgcctac atcaacatcg 23100

gggcgcgctg gtcgctggac cccatggaca acgtcaaccc cttcaaccac caccgcaacg 23160

cgggcctgcg ctaccgctcc atgctcctgg gcaacgggcg ctacgtgccc ttccacatcc 23220

aggtgcccca aaagttttttc gccatcaaga gcctcctgct cctgcccggg tcctacacct 23280

acgagtggaa cttccgcaag gacgtcaaca tgatcctgca gagctccctc ggcaacgacc 23340

tgcgcacgga cggggcctcc atcgccttca ccagcatcaa cctctacgcc accttcttcc 23400

ccatggcgca caacaccgcc tccacgctcg aggccatgct gcgcaacgac accaacgacc 23460

agtccttcaa cgactacctc tcggcggcca acatgctcta ccccatcccg gccaacgcca 23520

ccaacgtgcc catctccatc ccctcgcgca actgggccgc cttccgcgga tggtccttca 23580

cgcgcctcaa gacccgcgag acgccctcgc tcggctccgg gttcgacccc tacttcgtct 23640

actcgggctc catcccctac ctcgacggca ccttctacct caaccacacc ttcaagaagg 23700

tctccatcac cttcgactcc tccgtcagct ggcccggcaa cgaccgcctc ctgacgccca 23760

acgagttcga aatcaagcgc accgtcgacg gagagggata caacgtggcc cagtgcaaca 23820

tgaccaagga ctggttcctg gtccagatgc tggcccacta caacatcggc taccagggct 23880

tctacgtgcc cgagggctac aaggaccgca tgtactcctt cttccgcaac ttccagccca 23940

tgagccgcca ggtcgtggac gaggtcaact acaaggacta ccaggccgtc accctggcct 24000

accagcacaa caactcgggc ttcgtcggct acctcgcgcc caccatgcgc cagggccagc 24060

cctaccccgc caactacccc tacccgctca tcggcaagag cgccgtcgcc agcgtcaccc 24120

agaaaaagtt cctctgcgac cgggtcatgt ggcgcatccc cttctccagc aacttcatgt 24180

ccatgggcgc gctcaccgac ctcggccaga acatgctcta cgccaactcc gcccacgcgc 24240

tagacatgaa tttcgaagtc gaccccatgg atgagtccac ccttctctat gttgtcttcg 24300

aagtcttcga cgtcgtccga gtgcaccagc cccaccgcgg cgtcatcgag gccgtctacc 24360

tgcgcacgcc cttctcggcc ggcaacgcca ccacctaaag ccccgctctt gcttcttgca 24420

agatgacggc ctgtggctcc ggcgagcagg agctcagggc catcctccgc gacctgggct 24480

gcgggccctg cttcctgggc accttcgaca agcgcttccc gggattcatg gccccgcaca 24540

agctggcctg cgccatcgtc aacacggccg gccgcgagac cgggggcgag cactggctgg 24600

ccttcgcctg gaacccgcgc tcccacacct gctacctctt cgaccccttc gggttctcgg 24660

acgagcgcct caagcagatc taccagttcg agtacgaggg cctgctgcgc cgcagcgccc 24720

tggccaccga ggaccgctgc atcaccctgg aaaagtccac ccagaccgtg cagggtccgc 24780

gctcggccgc ctgcgggctc ttctgctgca tgttcctgca cgccttcgtg cactggcccg 24840

accgccccat ggacaagaac cccaccatga acttgctgac gggggtgccc aacggcatgc 24900

tccagtcgcc ccaggtggaa cccaccctgc gccgcaacca ggaggcgctc taccgcttcc 24960

tcaacgccca ctccgcctac tttcgctccc accgcgcgcg catcgagaag gccaccgcct 25020

tcgaccgcat gaatcaagac atgtaaactg tgtgtatgtg aatgctttat tcatcataat 25080

aaacagcaca tgtttatgcc accttctctg aggctctgac tttatttaga aatcgaaggg 25140

gttctgccgg ctctcggcgt gccccgcggg cagggatacg ttgcggaact ggtacttggg 25200

cagccacttg aactcgggga tcagcagctt cggcacgggg aggtcgggga acgagtcgct 25260

ccacagcttg cgcgtgagtt gcagggcgcc cagcaggtcg ggcgcggaga tcttgaaatc 25320

gcagttggga cccgcgttct gcgcgcgaga gttgcggtac acggggttgc agcactggaa 25380

caccatcagg gccgggtgct tcacgctcgc cagcaccgtc gcgtcggtga tgccctccac 25440

gtccagatcc tcggcgttgg ccatcccgaa gggggtcatc ttgcaggtct gccgccccat 25500

gctgggcacg cagccgggct tgtggttgca atcgcagtgc agggggatca gcatcatctg 25560

agcctgctcg gagctcatgc ccgggtacat ggccttcatg aaagcctcca gctggcggaa 25620

ggcctgctgc gccttgccgc cctcggtgaa gaagacccca caggacttgc tagagaactg 25680

gttggtggcg cagcccgcgt cgtgcacgca gcagcgcgcg tcgttgttgg ccagctgcac 25740

cacgctgcgc ccccagcggt tctgggtgat cttggcccgg tcggggttct ccttcagcgc 25800

gcgctgcccg ttctcgctcg ccacatccat ctcgatcgtg tgctccttct ggatcatcac 25860

ggtcccgtgc aggcaccgca gcttgccctc ggcctcggtg cacccgtgca gccacagcgc 25920

gcagccggtg cactcccagt tcttgtgggc gatctgggag tgcgagtgca cgaagccctg 25980

caggaagcgg cccatcatcg tggtcagggt cttgttgctg gtgaaggtca gcgggatgcc 26040

gcggtgctcc tcgttcacat acaggtggca gatgcggcgg tacacctcgc cctgctcggg 26100

catcagctgg aaggcggact tcaggtcgct ctccacgcgg taccgctcca tcagcagcgt 26160

catcacttcc atgcccttct cccaggccga aacgatcggc aggctcaggg ggttcttcac 26220

cgtcatctta gtcgccgccg ccgaagtcag ggggtcgttc tcgtccaggg tctcaaacac 26280

tcgcttgccg tccttctcgg tgatgcgcac ggggggaaag ctgaagccca cggccgccag 26340

ctcctcctcg gcctgccttt cgtcctcgct gtcctggctg atgtcttgca aaggcacatg 26400

cttggtcttg cggggtttct ttttgggcgg cagaggcggc ggcggagacg tgctgggcga 26460

gcgcgagttc tcgctcacca cgactatttc ttcttcttgg ccgtcgtccg agaccacgcg 26520

gcggtaggca tgcctcttct ggggcagagg cggaggcgac gggctctcgc ggttcggcgg 26580

gcggctggca gagccccttc cgcgttcggg ggtgcgctcc tggcggcgct gctctgactg 26640

acttcctccg cggccggcca ttgtgttctc ctagggagca acaagcatgg agactcagcc 26700

atcgtcgcca acatcgccat ctgcccccgc cgccgacgag aaccagcagc agcagaatga 26760

aagcttaacc gccccgccgc ccagccccac ctccgacgcc gccgcggccc cagacatgca 26820

agagatggag gaatccatcg agattgacct gggctacgtg acgcccgcgg agcacgagga 26880

ggagctggca gcgcgctttt cagccccgga agagaaccac caagagcagc cagagcagga 26940

agcagagagc gagcagcagc aggctgggct cgagcatggc gactacctga gcggggcaga 27000

ggacgtgctc atcaagcatc tggcccgcca aagcatcatc gtcaaggacg cgctgctcga 27060

ccgcgccgag gtgcccctca gcgtggcgga gctcagccgc gcctacgagc gcaacctctt 27120

ctcgccgcgc gtgcccccca agcgccagcc caacggcacc tgcgagccca acccgcgcct 27180

caacttctac ccggtcttcg cggtgcccga ggccctggcc acctaccacc tctttttcaa 27240

gaaccaaagg atccccgtct cctgccgcgc caaccgcacc cgcgccgacg ccctgctcaa 27300

cctgggtccc ggcgcccgcc tacctgatat cacctccttg gaagaggttc ccaagatctt 27360

cgagggtctg ggcagcgacg agactcgggc cgcgaacgct ctgcaaggaa gcggagagga 27420

gcatgagcac cacagcgccc tggtggagtt ggaaggcgac aacgcgcgcc tggcggtgct 27480

caagcgcacg gtcgagctga cccacttcgc ctacccggcg ctcaacctgc cccccaaggt 27540

catgagcgcc gtcatggacc aggtgctcat caagcgcgcc tcgcccctct cagaggagga 27600

gatgcaggac cccgagagct cggacgaggg caagcccgtg gtcagcgacg agcagctggc 27660

gcgctggctg ggagcgagca gcacccccca gagcctggaa gagcggcgca agctcatgat 27720

ggccgtggtc ctggtgaccg tggagctgga gtgtctgcgc cgcttcttcg ccgacgcgga 27780

gaccctgcgc aaggtcgagg agaacctgca ctacctcttc aggcacgggt tcgtgcgcca 27840

ggcctgcaag atctccaacg tggagctgac caacctggtc tcctacatgg gcatcctgca 27900

cgagaaccgc ctggggcaga acgtgctgca caccaccctg cgcggggagg cccgccgcga 27960

ctacatccgc gactgcgtct acctgtacct ctgccacacc tggcagacgg gcatgggcgt 28020

gtggcagcag tgcctggagg agcagaacct gaaagagctc tgcaagctcc tgcagaagaa 28080

cctcaaggcc ctgtggaccg ggttcgacga gcgcaccacc gcctcggacc tggccgacct 28140

catcttcccc gagcgcctgc ggctgacgct gcgcaacggg ctgcccgact ttatgagcca 28200

aagcatgttg caaaactttc gctctttcat cctcgaacgc tccgggatcc tgcccgccac 28260

ctgctccgca ctgccctcgg acttcgtgcc gctgaccttc cgcgagtgcc ccccgccgct 28320

ctggagccac tgctacttgc tgcgcctggc caactacctg gcctaccact cggacgtgat 28380

cgaggacgtc agcagcgagg gtctgctcga gtgccactgc cgctgcaacc tctgcacgcc 28440

gcaccgctcc ttggcctgca acccccagct gctgagcgag acccagatca tcggcacctt 28500

cgagttgcaa ggccccggcg agggcaaggg gggtctcaaa ctcaccccgg ggctgtggac 28560

ctcggcctac ttgcgcaagt tcgtgcccga ggactaccat cccttcgaga tcaggttcta 28620

cgaggaccaa tcccagccgc ccaaggccga gctgtcggcc tgcgtcatca cccaggggggc 28680

catcctggcc caattgcaag ccatccagaa atcccgccaa gaatttctgc tgaaaaaggg 28740

ccacggggtc tacttggacc cccagaccgg agaggagctc aaccccagct tcccccagga 28800

tgccccgagg aagcagcaag aagctgaaag tggagctgcc gctgccgccg gaggatttgg 28860

aggaagactg ggagagcagt caggcagagg agatggaaga ctgggacagc actcaggcag 28920

aggaggacag cctgcaagac agtctggagg aggaagacga ggtggaggag gaggcagagg 28980

aagaagcagc cgccgccaga ccgtcgtcct cggcggagga gaaagcaagc agcacggata 29040

ccatctccgc tccgggtcgg ggtcgcggcg gccgggccca cagtagatgg gacgagaccg 29100

ggcgcttccc gaaccccacc acccagaccg gtaagaagga gcggcaggga tacaagtcct 29160

ggcgggggca caaaaacgcc atcgtctcct gcttgcaagc ctgcgggggc aacatctcct 29220

tcacccggcg ctacctgctc ttccaccgcg gggtgaactt cccccgcaac atcttgcatt 29280

actaccgtca cctccacagc ccctactact gtttccaaga agaggcagaa acccagcagc 29340

agcagcagaa aaccagcggc agcagcagca gctagaaaat ccacagcggc ggcaggtgga 29400

ctgaggatcg cggcgaacga gccggcgcag acccgggagc tgaggaaccg gatctttccc 29460

accctctatg ccatcttcca gcagagtcgg gggcaggagc aggaactgaa agtcaagaac 29520

cgttctctgc gctcgctcac ccgcagttgt ctgtatcaca agagcgaaga ccaacttcag 29580

cgcactctcg aggacgccga ggctctcttc aacaagtact gcgcgctcac tcttaaagag 29640

tagcccgcgc ccgcccacac acggaaaaag gcgggaatta cgtcaccacc tgcgcccttc 29700

gcccgaccat catcatgagc aaagagattc ccacgcctta catgtggagc taccagcccc 29760

agatgggcct ggccgccggc gccgcccagg actactccac ccgcatgaac tggctcagtg 29820

ccgggcccgc gatgatctca cgggtgaatg acatccgcgc ccaccgaaac cagatactcc 29880

tagaacagtc agcgatcacc gccacgcccc gccatcacct taatccgcgt aattggcccg 29940

ccgccctggt gtaccaggaa attccccagc ccacgaccgt actacttccg cgagacgccc 30000

aggccgaagt ccagctgact aactcaggtg tccagctggc cggcggcgcc gccctgtgtc 30060

gtcaccgccc cgctcagggt ataaagcggc tggtgatccg aggcagaggc acacagctca 30120

acgacgaggt ggtgagctct tcgctgggtc tgcgacctga cggagtcttc caactcgccg 30180

gatcggggag atcttccttc acgcctcgtc aggccgtcct gactttggag agttcgtcct 30240

cgcagccccg ctcgggcggc atcggcactc tccagttcgt ggaggaggttc actccctcgg 30300

tctacttcaa ccccttctcc ggctcccccg gccactaccc ggacgagttc atcccgaact 30360

tcgacgccat cagcgagtcg gtggacggct acgattgaat gtcccatggt ggcgcggctg 30420

acctagctcg gcttcgacac ctggaccact gccgccgctt ccgctgcttc gctcgggatc 30480

tcgccgagtt tgcctacttt gagctgcccg aggagcaccc tcagggcccg gcccacggag 30540

tgcggatcgt cgtcgaaggg ggcctcgact cccacctgct tcggattttc agccagcgtc 30600

cgatcctggt cgagcgcgag caaggacaga cccttctgac cctgtactgc atctgcaacc 30660

accccggcct gcatgaaagt ctttgttgtc tgctgtgtac tgagtataat aaaagctgag 30720

atcagcgact actccggact cgattgtggt gttcctgcta tcaaccggtc cctgttcttc 30780

accgggaacg agaccgagct ccagctccag tgtaagcccc acaagaagta tctcacctgg 30840

ctgttccagg gctctccgat cgccgttgtc aaccactgcg acaacgacgg agtcctgctg 30900

agcggccctg ccaaccttac tttttccacc cgcagaagca agctccagct cttccaaccc 30960

ttcctccccg ggacctatca gtgcgtctcg ggaccctgcc atcacacctt ccacctgatc 31020

ccgaatacca cagcgccgct ccccgctact aacaaccaaa ctacccacca acgccaccgt 31080

cgcgaccttt ctgaatctaa tactaccacc cacaccggag gtgagctccg aggtcgacca 31140

acctctggga tttactacgg ggttaaccac gtggttacta tgtccttccg agtgagagac 31200

acaaaaaatt ccaacacact attgcaatga aaataaattt cctttattag ccagaagtca 31260

gatgctcaag gggcttcatg atgtccccat aatttttggc agagggaaaa agatctccat 31320

ggcctaggtc tagattaggc ggagcttaaa tagcccatca cacgattgat ggtcaccaca 31380

cgagtgctga aggcgtgcag taaaatgcac agcttcatct tgacacgata agggtcagcc 31440

tctcccacgg ggggcttctg tcttaaagtc tcgccgttgt ggttgaggga ctgcatcagt 31500

tcgtcgatgg ccaccagcat gcccttgtct aaaatgatct gctggtggtt gtggttctgt 31560

aaagcggcat tgatagcttg gaactcggtc tggtacatct ttaaatcttc gtagatgctg 31620

cccagacata aagtcatcat taaagaggtc ttctgggggg gtaaacaaga gcctcttgtg 31680

gtggagctgg tctcacgagt ggctaaacag ctctcgttct tgtgcagctc cagaggtaaa 31740

caagtcttca gtgtgctggt ctggtcacga gtgatgtcct cgtggtcgat atcctcggcg 31800

gtgcagctgt agtgcttgag cttctcacga gcggtcttca ccatgtcgtc ggtggtcttc 31860

agcagattac gagactggct taaacaccta gcggggccgc taacggggat cactctggct 31920

aaagataaat ggttcagtaa agctaaagtg gctaaaaaca gtaaatatct gctctggcac 31980

atggggccag gattagactc gacgtcgcca gcgagcttga ggagatcaaa gttcagagtc 32040

tgcttgacgg acctcaccct acaaggcaca caagcccact tgctgcagct gctgttgtag 32100

taacgatctt gagcttgcac gcacacattg ccgcccttac actgcacctc ggtgctggtc 32160

ttctccacca gaaaggcgcc cttctggttg cagccttcct cggtctcctt catcttctcc 32220

ttcttcctct ggatcctcac gaaaaacttt aaagagaagt aggagtgggg ggtggaccag 32280

ctatcggggt actcccagct cacctcaact tgggagttct tgaggggctt catctgcaga 32340

ttcttggggg gatcgggctt gataatgtct ctgataaaga agcttgtgga gtaattctcg 32400

tacttgttct gctgacgagc ctctaaagcc agttcgatgg gtaaagtctc ctcagcggta 32460

ggacaagtga cgtcttcttg gcagctcacg ctgtacttct cgtagtccct ctggtcgagg 32520

gtcaccttct cggcggataa agaggccatg ccacatgtca cggcacgaga gtcggggctg 32580

ctgctggagc tcttgatatt gaactttaaa tccatattcc tctggaccag ccaagaacaa 32640

gtaaaacgac cggagtagtt gggggcctcg cactttaaaa aggtcttgtt cttgaaattc 32700

ttgaggatct ctgtgctcca gatgccgttc tccttcttgt gcagcagtaa atgggagtgg 32760

ctgagtgtct cgccgccttt gtgacaagta tactggccgg catcgaggaa ctccttcacg 32820

gtgatggtta aagtcttgcc ggagccgatc acgccgtgtc tctgatcgct ggtccaagtg 32880

atgtcgtcct cttcgggggt gtcacaagtt aaattcacgg tttcgccggg ggcatcgggt 32940

gtccagtcca cctccacgac gtacacatcc ttctccagct cccacatggc cattaaaggg 33000

gagaccagca gcacgatggc aaaccagctg atggtcagct tctgggggca catggtccta 33060

ggctgttcgt cacccaggac ctggctagcc tgcccagtgc ctcacgacca acttctgcag 33120

cttaagttcg agactgttgt gtcagaagca ctgactgcgt tagcaattta actgtgataa 33180

actaccgcaa taaagcttgc tcccgcccgc cgcgcgcttc gctttttata gggccgccgc 33240

cgccgccgcc tcgccataaa aggaaacttt cggagcgcgc cgctctgatt ggctgccgcc 33300

gcacctctcc gcctcgcccc gccccgcccc tcgccccgcc ccgccccgcc tggcgcgcgc 33360

cccccccccc cgcccccatc gctgcacaaa ataattaaaa aataaataaa tacaaaattg 33420

ggggtgggga ggggggggag atggggagag tgaagcagaa cgtggggatc cgcgatccat 33480

taattaaggg gattccatat ggtacgtaca tcgcctctcc tacgagctcc tgcagcagcg 33540

ccagaagttc acctgcctgg tcggagtcaa ccccatcgtc atcacccagc agtcgggcga 33600

taccaagggg tgcatccact gctcctgcga ctcccccgac tgcgtccaca ctctgatcaa 33660

gaccctctgc ggcctccgcg acctcctccc catgaactaa tcaccccctt atccagtgaa 33720

ataaagatca tattgatgat gattttacag aaataaagat acaatcatat tgatgatttg 33780

agtttaataa aaaataaaga atcacttact tgaaatctga taccaggtct ctgtccatgt 33840

tttctgccaa caccacttca ctcccctctt cccagctctg gtactgcagg ccccggcggg 33900

ctgcaaactt cctccacacg ctgaagggga tgtcaaattc ctcctgtccc tcaatcttca 33960

ttttatcttc tatcagatgt ccaaaaagcg cgtccgggtg gatgatgact tcgaccccgt 34020

ctacccctac gatgcagaca acgcaccgac cgtgcccttc atcaaccccc ccttcgtctc 34080

ttcagatgga ttccaagaga agcccctggg ggtgctgtcc ctgcgactgg ccgaccccgt 34140

caccaccaag aacggggaaa tcaccctcaa gctgggagag ggggtggacc tcgactcctc 34200

gggaaaactc atctccaaca cggccaccaa ggccgccgcc cctctcagtt tttccaacaa 34260

caccatttcc cttaacatgg atcacccctt ttacactaaa gatggaaaat tatccttaca 34320

agtttctcca ccattaaata tactgagaac aagcattcta aacacactag ctttaggttt 34380

tggatcaggt ttaggactcc gtggctctgc cttggcagta cagttagtct ctccacttac 34440

atttgatact gatggaaaca taaagcttac cttagacaga ggtttgcatg ttacaacagg 34500

agatgcaatt gaaagcaaca taagctgggc taaaggttta aaatttgaag atggagccat 34560

agcaaccaac attggaaatg ggttagagtt tggaagcagt agtacagaaa caggtgttga 34620

tgatgcttac ccaatccaag ttaaacttgg atctggcctt agctttgaca gtacaggagc 34680

cataatggct ggtaacaaag aagacgataa actcactttg tggacaacac ctgatccatc 34740

gccaaactgt caaatactcg cagaaaatga tgcaaaacta acactttgct tgactaaatg 34800

tggtagtcaa atactggcca ctgtgtcagt cttagttgta ggaagtggaa acctaaaccc 34860

cattactggc accgtaagca gtgctcaggt gtttctacgt tttgatgcaa acggtgttct 34920

tttaacagaa cattctacac taaaaaaata ctgggggtat aggcagggag atagcataga 34980

tggcactcca tataccaatg ctgtaggatt catgcccaat ttaaaagctt atccaaagtc 35040

acaaagttct actactaaaa ataatatagt agggcaagta tacatgaatg gagatgtttc 35100

aaaacctatg cttctcacta taaccctcaa tggtactgat gacagcaaca gtacatattc 35160

aatgtcattt tcatacacct ggactaatgg aagctatgtt ggagcaacat ttggggctaa 35220

ctcttatacc ttctcataca tcgcccaaga atgaacactg tatcccaccc tgcatgccaa 35280

cccttcccac cccactctgt ggaaaaaact ctgaaacaca aaataaaata aagttcaagt 35340

gttttattga ttcaacagtt ttacaggatt cgagcagtta ttttttcctcc accctcccag 35400

gacatggaat acaccaccct ctccccccgc acagccttga acatctgaac gccattggtg 35460

atggacatgc ttttggtctc cacgttccac acagtttcag agcgagccag tctcgggtcg 35520

gtcagggaga tgaaaccctc cgggcacaat tgggagaagt actcgcctat tatctggaag 35580

aagcagaaga gcggcggtgg gaatcatagt ccgcgaacgg gatcggccgg tggtgtcgca 35640

tcaggccccg cagcagtcgc tgccgccgcc gctccgtcaa gctgctgctc agggggtccg 35700

ggtccaggga ctccctcagc atgatgccca cggccctcag catcagtcgt ctggtgcggc 35760

gggcgcagca gcgcatgcgg atctcgctca ggtcgctgca gtacgtgcaa cacagaacca 35820

ccaggttgtt caacagtcca tagttcaaca cgctccagcc gaaactcatc gcgggaagga 35880

tgctacccac gtggccgtcg taccagatcc tcaggtaaat caagtggtgc cccctccaga 35940

acacgctgcc cacgtacatg atctccttgg gcatgtggcg gttcaccacc tcccggtacc 36000

acatcaccct ctggttgaac atgcagcccc ggatgatcct gcggaaccac agggccagca 36060

ccgccccgcc cgccatgcag cgaagagacc ccgggtcccg gcaatggcaa tggaggaccc 36120

accgctcgta cccgtggatc atctgggagc tgaacaagtc tatgttggca cagcacaggc 36180

atatgctcat gcatctcttc agcactctca actcctcggg ggtcaaaacc atatcccagg 36240

gcacgggggaa ctcttgcagg acagcgaacc ccgcagaaca gggcaatcct cgcacagaac 36300

ttacattgtg catggacagg gtatcgcaat caggcagcac cgggtgatcc tccaccagag 36360

aagcgcgggt ctcggtctcc tcacagcgtg gtaagggggc cggccgatac gggtgatggc 36420

gggacgcggc tgatcgtgtt cgcgaccgtg tcatgatgca gttgctttcg gacatatttc 36480

ctgaagtctt ggcgcgccaa agtctagaca gcgtccatag cttaccgagc agcagcagca 36540

gcacacaaca ggcgcaagag tcagagaaag gctgagctct aacctgtcca cccgctctct 36600

gctcaatata tagcccagat ctacactgac gtaaaggcca aagtctaaaa atacccgcca 36660

aatagtcaca cacgcccagc acacgcccag aaaccggtga cacactcaaa aaaatacgcg 36720

cacttcctca aacgcccaaa ctgccgtcat ttccgggttc ccacgctacg tcatcaaaac 36780

acgactttca aattccgtcg accgttaaaa acgtcacccg ccccgcccct aacggtcgcc 36840

cgtctctcag ccaatcagcg ccccgcatcc ccaaattcaa acacctcatt tgcatattaa 36900

cgcgcaccaa aagtttgagg tatattattg atgatgattt aaatggcgcg ccgggcccgg 36960

gc 36962

<210> 20

<211> 34703

<212> DNA

<213> Artificial Sequence

<400> 20

aaatcatcat caataatata cctcaaactt ttggtgcgcg ttaatatgca aatgaggtgt 60

ttgaatttgg ggatgcgggg cgctgattgg ctgagagacg ggcgaccgtt aggggcgggg 120

cgggtgacgt tttgatgacg tggccgtgag gcggagccgg tttgcaagtt ctcgtgggaa 180

aagtgacgtc aaacgaggtg tggtttgaac acggaaatac tcaattttcc cgcgctctct 240

gacaggaaat gaggtgtttc tgggcggatg caagtgaaaa cgggccattt tcgcgcgaaa 300

actgaatgag gaagtgaaaa tctgagtaat tccgcgttta tggcagggag gagtatttgc 360

cgagggccga gtagactttg accgattacg tgggggtttc gattaccgta tttttcacct 420

aaatttccgc gtacggtgtc aaagtccggt gtttttacgt aggcgtcagc tgatcgccag 480

ggtatttaaa cctgcgctct ctagtcaaga ggccactctt gagtgccagc gagtagagtt 540

ttctcctccg cgccgcgagt cagatctaca ctttgaaagg cgatcgccga tatcatttcc 600

ccgaaaagtg ccacctgacc gtaactataa cggtcctaag gtagcgaaag ctcagatctc 660

ccgatcccct atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt 720

atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta 780

caacaaggca aggcttgacc gacaattgca tgaagaatct gcttagggtt aggcgttttg 840

cgctgcttcg cgatgtacgg gccagatata cgcgttgaca ttgattattg actagttatt 900

aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat 960

aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa 1020

taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg 1080

agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc 1140

cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct 1200

tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga 1260

tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa 1320

gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc 1380

caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg 1440

aggtctatat aagcagagct cgtttagtga accgtcagat cactagaagc tttattgcgg 1500

tagtttatca cagttaaatt gctaacgcag tcagtgcttc tgacacaaca gtctcgaact 1560

taagctgcag aagttggtcg tgaggcactg ggcaggtaag tatcaaggtt acaagacagg 1620

tttaaggaga ccaatagaaa ctgggcttgt cgagacagag aagactcttg cgtttctgat 1680

aggcacctat tggtcttact gacatccact ttgcctttct ctccacaggt gtccactccc 1740

agttcaatta cagctcttaa ggctagagta ctctagcccg ggatccaccg gtcgccacca 1800

tgtttcagga tccccaggag cggggccgca agctgccaca gctgtgcaca gagctccaga 1860

caaccattca cgatattatt ctcgagtgcg tctactgtaa gcagcagctc ctgcgccggg 1920

aggtctacga cttcgctaga cgcgacctgt gtatcgtcta ccgcgatgga aatccatacg 1980

ccgtcggcga taagtgcctc aagttttact ctaagatttc tgagtaccgg cactactgtt 2040

actcactgta cggaaccacc ctcgagcagc agtacaataa gcctctgtgt gatctgctca 2100

ttagatgcat taatggccag aagcctctct gtccagagga gaagcagcgg cacctcgata 2160

agaagcagcg gtttcacaat actaggggaa ggtggaccgg aaggtgtatg tcatgttgtc 2220

ggtcatcaag aactagacgc gagacacagc tcagaaagag gcgcgggtca ggcgcaccag 2280

tcaagcagac tctgaacttt gatctcctca agctcgctgg cgacgtcgag tctaatcctg 2340

gccccccacgg cgacacccca accctccacg agtacatgct ggatctccag cccgagacaa 2400

ccgacctcta cgggtacggg cagctcaatg attcatcaga ggaggaggat gagattgatg 2460

gccccgccgg acaggctgag cccgataggg cccactacaa tatcgtgaca ttttgttgca 2520

agggcgattc aacactccgc ctgtgcgtgc agtcaaccca cgtggatatt cggactctcg 2580

aggatctgct catgggaaca ctgggaattg tgtgccctat ttgttcccag aagcctagaa 2640

agaggcgcgg gtccggcgca acaaatttta gcctgctcaa gcaggctggc gacgtcgagg 2700

agaatcctgg gcccgctagg tttgaggatc caactagacg cgggtacaag ctccccgatc 2760

tgtgtacaga gctgaataca tcactccagg atattgagat tacttgcgtg tactgtaaga 2820

ccgtcctcga gctgactgag gtctttgagt tcgctagaaa ggatctcttc gtggtctacc 2880

gggattctat cccacacgcc gccggacaca agtgcattga cttttactct cgcattaggg 2940

agctcaggca ctactccgat agcgtctacg gggatacact ggagaagctg actaatactg 3000

gactgtacaa tctgctcatt agatgcctgc gcggacagaa gcctctcaat cccgctgaga 3060

agctgcggca cctgaatgag aagagacggt ttcacaatac cgccggacac taccggggcc 3120

agtgtcactc ttgttgtaat agggctaggc aggagcggct ccagagacgc cgcgagactc 3180

aggtccgcaa gaggcgcggg tccggcgcac ccgtgaagca gaccctgaac tttgatctcc 3240

tgaagctcgc tggggacgtg gagtctaacc ctgggccaca cggaccaaag gctaccctcc 3300

aggatatcgt cctgcacctc gagccacaga atgagattcc cgtcgacctg ctcggccacg 3360

gacagctgtc cgatagcgag gaggagaacg atgagattga tggggtgaat caccagcacc 3420

tgcccgctag acgcgccgag ccacagcggc acaccatgct gtgtatgtgt tgcaaggggg 3480

aggcacgcat cgagctggtg gtggagtctt ccgccgatga cctcagggct tttcagcagc 3540

tctttctgaa taccctgtcc ttcgtgtgcc cttggtgcgc ttcccagcag tgaagcggcc 3600

gccactgtgc tggatgatcc gagctcggta cctctagagt cgacccgggc ggccaaaccg 3660

ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt 3720

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat 3780

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag 3840

caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc 3900

ttctgaggcg gaaagaacca gcagatctgc agatctgaat tcatctatgt cgggtgcgga 3960

gaaagaggta atgaaatggc attatgggta ttatgggtct gcattaatga atcggccaga 4020

tatcgacata tgctggccac cgtacatgtg gcttcccatg ctcgcaagcc ctggcccgag 4080

ttcgagcaca atgtcatgac caggtgcaat atgcatctgg ggtcccggcg atcgcccgag 4140

gcatgttcat gccctaccag tgcaacatgc aatttgtgaa ggtgctgctg gagcccgatg 4200

ccatgtccag agtgagcctg acgggggtgt ttgacatgaa tgtggagctg tggaaaattc 4260

tgagatatga tgaatccaag accaggtgcc gggcctgcga atgcggaggc aagcacgcca 4320

ggcttcagcc cgtgtgtgtg gaggtgacgg aggacctgcg acccgatcat ttggtgttgt 4380

cctgcaacgg gacggagttc ggctccagcg gggaagaatc tgactagagt gagtagtgtt 4440

tgggggtggg tgggagcctg catgatgggc agaatgacta aaatctgtgt ttttctgtgt 4500

gttgcagcag catgagcgga agcgcctcct ttgagggagg ggtattcagc ccttatctga 4560

cggggcgtct cccctcctgg gcgggagtgc gtcagaatgt gatgggatcc acggtggacg 4620

gccggcccgt gcagcccgcg aactcttcaa ccctgaccta cgcgaccctg agctcctcgt 4680

ccgtggacgc agctgccgcc gcagctgctg cttccgccgc cagcgccgtg cgcggaatgg 4740

ccctgggcgc cggctactac agctctctgg tggccaactc gagttccacc aataatcccg 4800

ccagcctgaa cgaggagaag ctgttgctgc tgatggccca gctcgaggcc ctgacccagc 4860

gcctgggcga gctgacccag caggtggctc agctgcaggc ggagacgcgg gccgcggttg 4920

ccacggtgaa aaccaaataa aaaatgaatc aataaataaa cggagacggt tgttgatttt 4980

aacacagagt cttgaatctt tatttgattt ttcgcgcgcg gtaggccctg gaccaccggt 5040

ctcgatcatt gagcacccgg tggatctttt ccaggacccg gtagaggtgg gcttggatgt 5100

tgaggtacat gggcatgagc ccgtcccggg ggtggaggta gctccattgc agggcctcgt 5160

gctcgggggt ggtgttgtaa atcacccagt catagcaggg gcgcagggcg tggtgctgca 5220

cgatgtcttt gaggaggaga ctgatggcca cgggcagccc cttggtgtag gtgttgacga 5280

acctattgag ctgggaggga tgcatgcggg gggagatgag atgcatcttg gcctggatct 5340

tgagattggc gatgttcccg cccagatccc gccgggggtt catgttgtgc aggaccacca 5400

gcacggtgta tccggtgcac ttggggaatt tgtcatgcaa cttggaaggg aaggcgtgaa 5460

agaatttgga gacgcccttg tgaccgccca ggttttccat gcactcatcc atgatgatgg 5520

cgatggggccc gtgggcggcg gcctgggcaa agacgtttcg ggggtcggac acatcgtagt 5580

tgtggtcctg ggtgagctcg tcataggcca ttttaatgaa tttggggcgg agggtacccg 5640

actgggggac aaaggtgccc tcgatcccgg gggcgtagtt cccctcgcag atctgcatct 5700

cccaggcctt gagctcggag ggggggatca tgtccacctg cggggcgatg aaaaaaacgg 5760

tttccggggc gggggagatg agctgcgccg aaagcaggtt ccggagcagc tgggacttgc 5820

cgcagccggt ggggccgtag atgaccccga tgaccggctg caggtggtag ttgagggaga 5880

gacagctgcc gtcctcgcgg aggagggggg ccacctcgtt catcatctcg cgcacatgca 5940

tgttctcgcg cacgagttcc gccaggaggc gctcgccccc cagcgagagg agctcttgca 6000

gcgaggcgaa gtttttcagc ggcttgagcc cgtcggccat gggcattttg gagagggtct 6060

gttgcaagag ttccagacgg tcccaagagct cggtgatgtg ctctagggca tctcgatcca 6120

gcagacctcc tcgtttcgcg ggttggggcg actgcgggag tagggcacca ggcgatgggc 6180

gtccagcgag gccagggtcc ggtccttcca gggtcgcagg gtccgcgtca gcgtggtctc 6240

cgtcacggtg aaggggtgcg cgccgggctg ggcgcttgcg agggtgcgct tcaggctcat 6300

ccggctggtc gagaaccgct cccggtcggc gccctgcgcg tcggccaggt agcaattgag 6360

catgagttcg tagttgagcg cctcggccgc gtggcccttg gcgcggagct tacctttgga 6420

agtgtgtccg cagacgggac agaggaggga cttgagggcg tagagcttgg gggcgaggaa 6480

gacggactcg ggggcgtagg cgtccgcgcc gcagctggcg cagacggtct cgcactccac 6540

gagccaggtg aggtcggggc ggtcggggtc aaaaacgagg tttcctccgt gctttttgat 6600

gcgtttctta cctctggtct ccatgagctc gtgtccccgc tgggtgacaa agaggctgtc 6660

cgtgtccccg tagaccgact ttatgggccg gtcctcgagc ggggtgccgc ggtcctcgtc 6720

gtagaggaac cccgcccact ccgagacgaa ggcccgggtc caggccagca cgaaggaggc 6780

cacgtgggag gggtagcggt cgttgtccac cagcgggtcc accttctcca gggtatgcaa 6840

gcacatgtcc ccctcgtcca catccaggaa ggtgattggc ttgtaagtgt aggccacgtg 6900

accgggggtc ccggccgggg gggtataaaa gggggcgggc ccctgctcgt cctcactgtc 6960

ttccggatcg ctgtccagga gcgccagctg ttggggtagg tattccctct cgaaggcggg 7020

catgacctcg gcactcaggt tgtcagtttc tagaaacgag gaggatttga tattgacggt 7080

gccgttggag acgcctttca tgagcccctc gtccatctgg tcagaaaaga cgatcttttt 7140

gttgtcgagc ttggtggcga aggagccgta gagggcgttg gagagcagct tggcgatgga 7200

gcgcatggtc tggttctttt ccttgtcggc gcgctccttg gcggcgatgt tgagctgcac 7260

gtactcgcgc gccacgcact tccattcggg gaagacggtg gtgagctcgt cgggcacgat 7320

tctgacccgc cagccgcggt tgtgcagggt gatgaggtcc acgctggtgg ccacctcgcc 7380

gcgcaggggc tcgttggtcc agcagaggcg cccgcccttg cgcgagcaga aggggggcag 7440

cgggtccagc atgagctcgt cgggggggtc ggcgtccacg gtgaagatgc cgggcaggag 7500

ctcggggtcg aagtagctga tgcaggtgcc cagatcgtcc agacttgctt gccagtcgcg 7560

cacggccagc gcgcgctcgt aggggctgag gggcgtgccc cagggcatgg ggtgcgtgag 7620

cgcggaggcg tacatgccgc agatgtcgta gacgtagagg ggctcctgga ggacgccgat 7680

gtaggtgggg tagcagcgcc ccccgcggat gctggcgcgc acgtagtcgt acagctcgtg 7740

cgagggcgcg aggagccccg tgccgagatt ggagcgctgc ggcttttcgg cgcggtagac 7800

gatctggcgg aagatggcgt gggagttgga ggagatggtg ggcctctgga agatgttgaa 7860

gtgggcatgg ggcagtccga ccgagtccct gatgaagtgg gcgtaggagt cctgcagctt 7920

ggcgacgagc tcggcggtga cgaggacgtc cagggcgcag tagtcgaggg tctcttggat 7980

gatgtcgtac ttgagctggc ccttctgctt ccacagctcg cggttgagaa ggaactcttc 8040

gcggtccttc cagtactctt cgagggggaa cccgtcctga tcggcacggt aagagcccac 8100

catgtagaac tggttgacgg ccttgtaggc gcagcagccc ttctccacgg ggagggcgta 8160

agcttgcgcg gccttgcgca gggaggtgtg ggtgagggcg aaggtgtcgc gcaccatgac 8220

tttgaggaac tggtgcttga agtcgaggtc gtcgcagccg ccctgctccc agagctggaa 8280

gtccgtgcgc ttcttgtagg cggggttggg caaagcgaaa gtaacatcgt tgaagaggat 8340

cttgcccgcg cggggcatga agttgcgagt gatgcggaaa ggctggggca cctcggcccg 8400

gttgttgatg acctgggcgg cgaggacgat ctcgtcgaag ccgttgatgt tgtgcccgac 8460

gatgtagagt tccacgaatc gcgggcggcc cttgacgtgg ggcagcttct tgagctcgtc 8520

gtaggtgagc tcggcggggt cgctgagccc gtgctgctcg agggcccagt cggcgacgtg 8580

ggggttggcg ctgaggaagg aagtccagag atccacggcc agggcggtct gcaagcggtc 8640

ccggtactga cggaactgct ggcccacggc cattttttcg ggggtgacgc agtagaaggt 8700

gcgggggtcg ccgtgccagc ggtcccactt gagctggagg gcgaggtcgt gggcgagctc 8760

gacgagcggc gggtccccgg agagtttcat gaccagcatg aaggggacga gctgcttgcc 8820

gaaggacccc atccaggtgt aggtttccac atcgtaggtg aggaagagcc tttcggtgcg 8880

aggatgcgag ccgatgggga agaactggat ctcctgccac cagttggagg aatggctgtt 8940

gatgtgatgg aagtagaaat gccgacggcg cgccgagcac tcgtgcttgt gtttatacaa 9000

gcgtccgcag tgctcgcaac gctgcacggg atgcacgtgc tgcacgagct gtacctgggt 9060

tcctttgacg aggaatttca gtgggcagtg gagcgctggc ggctgcatct ggtgctgtac 9120

tacgtcctgg ccatcggcgt ggccatcgtc tgcctcgatg gtggtcatgc tgacgagccc 9180

gcgcgggagg caggtccaga cctcggctcg gacgggtcgg agagcgagga cgagggcgcg 9240

caggccggag ctgtccaggg tcctgagacg ctgcggagtc aggtcagtgg gcagcggcgg 9300

cgcgcggttg acttgcagga gcttttccag ggcgcgcggg aggtccagat ggtacttgat 9360

ctccacggcg ccgttggtgg cgacgtccac ggcttgcagg gtcccgtgcc cctggggcgc 9420

caccaccgtg ccccgtttct tcttgggcgg cggcggctcc atgcttagaa gcggcggcga 9480

ggacgcgcgc cgggcggcag gggcggctcg gggcccggag gcaggggcgg caggggcacg 9540

tcggcgccgc gcgcgggcag gttctggtac tgcgcccgga gaagactggc gtgagcgacg 9600

acgcgacggt tgacgtcctg gatctgacgc ctctgggtga aggccacggg acccgtgagt 9660

ttgaacctga aagagagttc gacagaatca atctcggtat cgttgacggc ggcctgccgc 9720

aggatctctt gcacgtcgcc cgagttgtcc tggtaggcga tctcggtcat gaactgctcg 9780

atctcctcct cctgaaggtc tccgcggccg gcgcgctcga cggtggccgc gaggtcgttg 9840

gagatgcggc ccatgagctg cgagaaggcg ttcatgccgg cctcgttcca gacgcggctg 9900

tagaccacgg ctccgtcggg gtcgcgcgcg cgcatgacca cctgggcgag gttgagctcg 9960

acgtggcgcg tgaagaccgc gtagttgcag aggcgctggt agaggtagtt gagcgtggtg 10020

gcgatgtgct cggtgacgaa gaagtacatg atccagcggc ggagcggcat ctcgctgacg 10080

tcgcccaggg cttccaagcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac 10140

tgggagttgc gcgccgagac ggtcaactcc tcctccagaa gacggatgag ctcggcgatg 10200

gtggcgcgca cctcgcgctc gaaggccccg gggggctcct cttccatttc ctcctcttcc 10260

tcctccacta acatctcttc tacttcctcc tcaggaggcg gcggcggggg aggggccctg 10320

cgtcgccggc ggcgcacggg cagacggtcg atgaagcgct cgatggtctc cccgcgccgg 10380

cgacgcatgg tctcggtgac ggcgcgcccg tcctcgcggg gccgcagcgt gaagacgccg 10440

ccgcgcatct ccaggtggcc gccggggggg tctccgttgg gcagggagag ggcgctgacg 10500

atgcatctta tcaattgacc cgtagggact ccgcgcaagg acctgagcgt ctcgagatcc 10560

acgggatccg aaaaccgctg aacgaaggct tcgagccagt cgcagtcgca aggtaggctg 10620

agcccggttt cttgttcttc gggtatttgg tcgggaggcg ggcgggcgat gctgctggtg 10680

atgaagttga agtaggcggt cctgagacgg cggatggtgg cgaggagcac caggtccttg 10740

ggcccggctt gctggatgcg cagacggtcg gccatgcccc aggcgtggtc ctgacacctg 10800

gcgaggtcct tgtagtagtc ctgcatgagc cgctccacgg gcacctcctc ctcgcccgcg 10860

cggccgtgca tgcgcgtgag cccgaacccg cgctgcggct ggacgagcgc caggtcggcg 10920

acgacgcgct cggcgaggat ggcctgctgg atctgggtga gggtggtctg gaagtcgtcg 10980

aagtcgacga agcggtggta ggctccggtg ttgatggtgt aggagcagtt ggccatgacg 11040

gaccagttga cggtctggtg gccggggcgc acgagctcgt ggtacttgag gcgcgagtag 11100

gcgcgcgtgt cgaagatgta gtcgttgcag gtgcgcacga ggtactggta tccgacgagg 11160

aagtgcggcg gcggctggcg gtagagcggc catcgctcgg tggcgggggc gccgggcgcg 11220

aggtcctcga gcatgaggcg gtggtagccg tagatgtacc tggacatcca ggtgatgccg 11280

gcggcggtgg tggaggcgcg cgggaactcg cggacgcggt tccagatgtt gcgcagcggc 11340

aggaagtagt tcatggtggc cgcggtctgg cccgtgaggc gcgcgcagtc gtggatgctc 11400

tagacatacg ggcaaaaacg aaagcggtca gcggctcgac tccgtggcct ggaggctaag 11460

cgaacgggtt gggctgcgcg tgtaccccgg ttcgaatctc gaatcaggct ggagccgcag 11520

ctaacgtggt actggcactc ccgtctcgac ccaagcctgc taacgaaacc tccaggatac 11580

ggaggcgggt cgtttttttgg ccttggtcgc tggtcatgaa aaactagtaa gcgcggaaag 11640

cggccgcccg cgatggctcg ctgccgtagt ctggagaaag aatcgccagg gttgcgttgc 11700

ggtgtgcccc ggttcgagcc tcagcgctcg gcgccggccg gattccgcgg ctaacgtggg 11760

cgtggctgcc ccgtcgtttc caagacccct tagccagccg acttctccag ttacggagcg 11820

agcccctctt ttttttcttgt gtttttgcca gatgcatccc gtactgcggc agatgcgccc 11880

ccaccctcca ccacaaccgc ccctaccgca gcagcagcaa cagccggcgc ttctgccccc 11940

gccccagcag cagcagccag ccactaccgc ggcggccgcc gtgagcggag ccggcgttca 12000

gtatgacctg gccttggaag agggcgaggg gctggcgcgg ctgggggcgt cgtcgccgga 12060

gcggcacccg cgcgtgcaga tgaaaaggga cgctcgcgag gcctacgtgc ccaagcagaa 12120

cctgttcaga gacaggagcg gcgaggagcc cgaggagatg cgcgcctccc gcttccacgc 12180

ggggcgggag ctgcggcgcg gcctggaccg aaagcgggtg ctgagggacg aggatttcga 12240

ggcggacgag ctgacgggga tcagccccgc gcgcgcgcac gtggccgcgg ccaacctggt 12300

cacggcgtac gagcagaccg tgaaggagga gagcaacttc caaaaatcct tcaacaacca 12360

cgtgcgcacg ctgatcgcgc gcgaggaggt gaccctgggc ctgatgcacc tgtgggacct 12420

gctggaggcc atcgtgcaga accccacgag caagccgctg acggcgcagc tgtttctggt 12480

ggtgcagcac agtcgggaca acgagacgtt cagggaggcg ctgctgaata tcaccgagcc 12540

cgagggccgc tggctcctgg acctggtgaa cattctgcag agcatcgtgg tgcaggagcg 12600

cgggctgccg ctgtccgaga agctggcggc catcaacttc tcggtgctga gcctgggcaa 12660

gtactacgct aggaagatct acaagacccc gtacgtgccc atagacaagg aggtgaagat 12720

cgatgggttt tacatgcgca tgaccctgaa agtgctgacc ctgagcgacg atctgggggt 12780

gtaccgcaac gacaggatgc accgcgcggt gagcgccagc cgccggcgcg agctgagcga 12840

ccaggagctg atgcacagcc tgcagcgggc cctgaccggg gccgggaccg agggggagag 12900

ctactttgac atgggcgcgg acctgcgctg gcagcccagc cgccgggcct tggaagctgc 12960

cggcggcgtg ccctacgtgg aggaggtgga cgatgaggag gaggagggcg agtacctgga 13020

agactgatgg cgcgaccgta tttttgctag atgcagcaac agccaccgcc gccgcctcct 13080

gatcccgcga tgcgggcggc gctgcagagc cagccgtccg gcattaactc ctcggacgat 13140

tggacccagg ccatgcaacg catcatggcg ctgacgaccc gcaatcccga agcctttaga 13200

cagcagcctc aggccaaccg gctctcggcc atcctggagg ccgtggtgcc ctcgcgctcg 13260

aaccccacgc acgagaaggt gctggccatc gtgaacgcgc tggtggagaa caaggccatc 13320

cgcggcgacg aggccgggct ggtgtacaac gcgctgctgg agcgcgtggc ccgctacaac 13380

agcaccaacg tgcagacgaa cctggaccgc atggtgaccg acgtgcgcga ggcggtgtcg 13440

cagcgcgagc ggttccaccg cgagtcgaac ctgggctcca tggtggcgct gaacgccttc 13500

ctgagcacgc agcccgccaa cgtgccccgg ggccaggagg actacaccaa cttcatcagc 13560

gcgctgcggc tgatggtggc cgaggtgccc cagagcgagg tgtaccagtc ggggccggac 13620

tacttcttcc agaccagtcg ccagggcttg cagaccgtga acctgagcca ggctttcaag 13680

aacttgcagg gactgtgggg cgtgcaggcc ccggtcgggg accgcgcgac ggtgtcgagc 13740

ctgctgacgc cgaactcgcg cctgctgctg ctgctggtgg cgcccttcac ggacagcggc 13800

agcgtgagcc gcgactcgta cctgggctac ctgcttaacc tgtaccgcga ggccatcggg 13860

caggcgcacg tggacgagca gacctaccag gagatcaccc acgtgagccg cgcgctgggc 13920

caggaggacc cgggcaacct ggaggccacc ctgaacttcc tgctgaccaa ccggtcgcag 13980

aagatcccgc cccagtacgc gctgagcacc gaggaggagc gcatcctgcg ctacgtgcag 14040

cagagcgtgg ggctgttctt gatgcaggag ggggccacgc ccagcgccgc gctcgacatg 14100

accgcgcgca acatggagcc cagcatgtac gcccgcaacc gcccgttcat caataagctg 14160

atggactact tgcatcgggc ggccgccatg aactcggact actttaccaa cgccatcttg 14220

aacccgcact ggctcccgcc gcccgggttc tacacgggcg agtacgacat gcccgacccc 14280

aacgacgggt tcctgtggga cgacgtggac agcagcgtgt tctcgccgcg gcccaccacc 14340

accaccgtgt ggaagaaaga gggcggggac cggcggccgt cctcggcgct gtccggtcgc 14400

gcgggtgctg ccgcggcggt gcccgaggct gccagcccct tcccgagcct gcccttttcg 14460

ctgaacagcg tgcgcagcag cgagctgggt cggctgacgc ggccgcgcct gctgggcgag 14520

gaggagtacc tgaacgactc cttgttgaag cccgagcgcg agaagaactt ccccaataac 14580

gggatagaga gcctggtgga caagatgagc cgctggaaga cgtacgcgca cgagcacagg 14640

gacgagcccc gagctagcag cgcaggcacc cgtagacgcc agcggcacga caggcagcgg 14700

ggactggtgt gggacgatga ggattccgcc gacgacagca gcgtgttgga cttgggtggg 14760

agtggtggtg gtaacccgtt cgctcacctg cgccccccgta tcgggcgcct gatgtaagaa 14820

tctgaaaaaa taaaagacgg tactcaccaa ggccatggcg accagcgtgc gttcttctct 14880

gttgtttgta gtagtatgat gaggcgcgtg tacccggagg gtcctcctcc ctcgtacgag 14940

agcgtgatgc agcaggcggt ggcggcggcg atgcagcccc cgctggaggc gccttacgtg 15000

cccccgcggt acctggcgcc tacggagggg cggaacagca ttcgttactc ggagctggca 15060

cccttgtacg ataccacccg gttgtacctg gtggacaaca agtcggcgga catcgcctcg 15120

ctgaactacc agaacgacca cagcaacttc ctgaccaccg tggtgcagaa caacgatttc 15180

acccccacgg aggccagcac ccagaccatc aactttgacg agcgctcgcg gtggggcggc 15240

cagctgaaaa ccatcatgca caccaacatg cccaacgtga acgagttcat gtacagcaac 15300

aagttcaagg cgcgggtgat ggtctcgcgc aagaccccca acggggtcac ggtaggggat 15360

gattatgatg gtagtcagga cgagctgacc tacgagtggg tggagtttga gctgcccgag 15420

ggcaacttct cggtgaccat gaccatcgat ctgatgaaca acgccatcat cgacaactac 15480

ttggcggtgg ggcggcagaa cggggtgctg gagagcgaca tcggcgtgaa gttcgacacg 15540

cgcaacttcc ggctgggctg ggaccccgtg accgagctgg tgatgccggg cgtgtacacc 15600

aacgaggcct tccaccccga catcgtcctg ctgcccggct gcggcgtgga cttcaccgag 15660

agccgcctca gcaacctgct gggcatccgc aagcggcagc ccttccagga gggcttccag 15720

atcctgtacg aggacctgga ggggggcaac atccccgcgc tcttggatgt cgaagcctat 15780

gaagaaagta aggaaaaagc agaggctgag gcaactacag ccgtggctac cgccgcgact 15840

gtggcagatg ccactgtcac caggggcgat acattcgcca cccaggcgga ggaagcagcc 15900

gccctagcgg cgaccgatga tagtgaaagt aagatagtca tcaagccggt ggagaaggac 15960

agcaagaaca ggagctacaa cgttctaccg gatggaaaga acaccgccta ccgcagctgg 16020

tacctggcct acaactacgg cgaccccgag aagggcgtgc gctcctggac gctgctcacc 16080

acctcggacg tcacctgcgg cgtggagcaa gtctactggt cgctgcccga catgatgcaa 16140

gacccggtca ccttccgctc cacgcgacaa gttagcaact acccggtggt gggcgccgag 16200

ctcctgcccg tctactccaa gagcttcttc aacgagcagg ccgtctactc gcagcagctg 16260

cgtgccttca cctcgctcac gcacgtcttc aaccgcttcc ccgagaacca gatcctcgtc 16320

cgcccgcccg cgcccaccat taccaccgtc agtgaaaacg ttcctgctct cacagatcac 16380

gggaccctgc cgctgcgcag cagtatccgg ggagtccagc gcgtgaccgt cactgacgcc 16440

agacgccgca cctgccccta cgtctacaag gccctgggcg tagtcgcgcc gcgcgtcctc 16500

tcgagccgca ccttctaaaa aatgtccatt ctcatctcgc ccagtaataa caccggttgg 16560

ggcctgcgcg cgcccagcaa gatgtacgga ggcgctcgcc aacgctccac gcaacacccc 16620

gtgcgcgtgc gcgggcactt ccgcgctccc tggggcgccc tcaagggccg cgtgcgctcg 16680

cgcaccaccg tcgacgacgt gatcgaccag gtggtggccg acgcgcgcaa ctacacgccc 16740

gccgccgcgc ccgcctccac cgtggacgcc gtcatcgaca gcgtggtggc cgacgcgcgc 16800

cggtacgccc gcgccaagag ccggcggcgg cgcatcgccc ggcggcaccg gagcaccccc 16860

gccatgcgcg cggcgcgagc cttgctgcgc agggccaggc gcacgggacg cagggccatg 16920

ctcagggcgg ccagacgcgc ggcctccggc agcagcagcg ccggcaggac ccgcagacgc 16980

gcggccacgg cggcggcggc ggccatcgcc agcatgtccc gcccgcggcg cggcaacgtg 17040

tactgggtgc gcgacgccgc caccggtgtg cgcgtgcccg tgcgcacccg cccccctcgc 17100

acttgaagat gctgacttcg cgatgttgat gtgtcccagc ggcgaggagg atgtccaagc 17160

gcaaatacaa ggaagagatg ctccaggtca tcgcgcctga gatctacggc cccgcggcgg 17220

cggtgaagga ggaaagaaag ccccgcaaac tgaagcgggt caaaaaggac aaaaaggagg 17280

aggaagatga cggactggtg gagtttgtgc gcgagttcgc cccccggcgg cgcgtgcagt 17340

ggcgcgggcg gaaagtgaaa ccggtgctgc ggcccggcac cacggtggtc ttcacgcccg 17400

gcgagcgttc cggctccgcc tccaagcgct cctacgacga ggtgtacggg gacgaggaca 17460

tcctcgagca ggcggtcgag cgtctgggcg agtttgctta cggcaagcgc agccgccccg 17520

cgcccttgaa agaggaggcg gtgtccatcc cgctggacca cggcaacccc acgccgagcc 17580

tgaagccggt gaccctgcag caggtgctgc cgagcgcggc gccgcgccgg ggcttcaagc 17640

gcgagggcgg cgaggatctg tacccgacca tgcagctgat ggtgcccaag cgccagaagc 17700

tggaggacgt gctggagcac atgaaggtgg accccgaggt gcagcccgag gtcaaggtgc 17760

ggcccatcaa gcaggtggcc ccgggcctgg gcgtgcagac cgtggacatc aagatcccca 17820

cggagcccat ggaaacgcag accgagcccg tgaagcccag caccagcacc atggaggtgc 17880

agacggatcc ctggatgcca gcggcttcca ccaccaccac tcgccgaaga cgcaagtacg 17940

gcgcggccag cctgctgatg cccaactacg cgctgcatcc ttccatcatc cccacgccgg 18000

gctaccgcgg cacgcgcttc taccgcggct acaccagcag ccgccgccgc aagaccacca 18060

cccgccgccg tcgtcgcagc cgccgcagca gcaccgcgac ttccgccttg gtgcggagag 18120

tgtatcgcag cgggcgcgag cctctgaccc tgccgcgcgc gcgctaccac ccgagcatcg 18180

ccatttaact accgcctcct acttgcagat atggccctca catgccgcct ccgcgtcccc 18240

attacgggct accgaggaag aaagccgcgc cgtagaaggc tgacggggaa cgggctgcgt 18300

cgccatcacc accggcggcg gcgcgccatc agcaagcggt tgggggggagg cttcctgccc 18360

gcgctgatcc ccatcatcgc cgcggcgatc ggggcgatcc ccggcatagc ttccgtggcg 18420

gtgcaggcct ctcagcgcca ctgagacaca aaaaagcatg gatttgtaat aaaaaaatgg 18480

actgacgctc ctggtcctgt gatgtgtgtt tttagatgga agacatcaat ttttcgtccc 18540

tggcaccgcg acacggcacg cggccgttta tgggcacctg gagcgacatc ggcaacagcc 18600

aactgaacgg gggcgccttc aattggagca gtctctggag cgggcttaag aatttcgggt 18660

ccacgctcaa aacctatggc aacaaggcgt ggaacagcag cacagggcag gcgctgaggg 18720

aaaagctgaa agagcagaac ttccagcaga aggtggtcga tggcctggcc tcgggcatca 18780

acggggtggt ggacctggcc aaccaggccg tgcagaaaca gatcaacagc cgcctggacg 18840

cggtcccgcc cgcggggtcc gtggagatgc cccaggtgga ggaggagctg cctcccctgg 18900

acaagcgcgg cgacaagcga ccgcgtcccg acgcggagga gacgctgctg acgcacacgg 18960

acgagccgcc cccgtacgag gaggcggtga aactgggtct gcccaccacg cggcccgtgg 19020

cgcctctggc caccggggtg ctgaaaccca gcagcagcag ccagcccgcg accctggact 19080

tgcctccgcc tgcttcccgc ccctccacag tggctaagcc cctgccgccg gtggccgtcg 19140

cgtcgcgcgc cccccgaggc cgcccccagg cgaactggca gagcactctg aacagcatcg 19200

tgggtctggg agtgcagagt gtgaagcgcc gccgctgcta ttaaaagaca ctgtagcgct 19260

taacttgctt gtctgtgtgt gtatatgtat gtccgccgac cagaaggagg aagaggcgcg 19320

tcgccgagtt gcaagatggc caccccatcg atgctgcccc agtgggcgta catgcacatc 19380

gccggacagg acgcttcgga gtacctgagt ccgggtctgg tgcagttcgc ccgcgccaca 19440

gacacctact tcagtctggg gaacaagttt aggaacccca cggtggcgcc cacgcacgat 19500

gtgaccaccg accgcagcca gcggctgacg ctgcgcttcg tgcccgtgga ccgcgaggac 19560

aacacctact cgtacaaagt gcgctacacg ctggccgtgg gcgacaaccg cgtgctggac 19620

atggccagca cctactttga catccgcggc gtgctggatc ggggccccag cttcaaaccc 19680

tactccggca ccgcctacaa cagcctagct cccaagggag cgcccaacac ctcacagtgg 19740

aaggattccg acagcaaaat gcatactttt ggagttgctg ccatgcccgg tgttgttggt 19800

aaaaaaatag aagccgatgg tctgcctatt ggaatagatt catcctctgg aactgacacc 19860

ataatttatg ctgataaaac tttccaacca gagccacagg ttggaagtga cagttgggtc 19920

gacaccaatg gtgcagagga aaaatatgga ggtagagctc ttaaggacac tacaaacatg 19980

aagccctgct acggttcttt tgccaggcct accaacaaag aaggtggaca ggctaacata 20040

aaagattctg aaactgccag cactactcct aactatgata tagatttggc attctttgac 20100

agcaaaaata ttgcagctaa ctacgatcca gatattgtaa tgtacacaga aaatgttgag 20160

ttgcaaactc cagatactca tattgtgttt aagccaggaa cttcagatga aagttcagaa 20220

gccaatttgg gccagcaggc catgcccaac agacccaact acatcgggtt cagagacaac 20280

tttatcgggc tcatgtacta caacagcact ggcaatatgg gtgtactggc tggtcaggcc 20340

tcccagctaa atgctgtggt ggacttgcag gacagaaaca ccgaactgtc ctaccagctc 20400

ttgcttgact ctctgggtga cagaaccagg tatttcagta tgtggaatca ggcggtggac 20460

agctatgacc ccgatgtgcg cattattgaa aatcacggtg tggaggatga actccccaat 20520

tattgcttcc ctttgaatgg tgtaggcttt acagatactt accagggtgt taaagttaag 20580

acagatacag ccgctactgg taccaatgga acgcagtggg acaaagatga taccacagtc 20640

agcactgcca atgagatcca ctcaggcaat cctttcgcca tggagatcaa catccaggcc 20700

aacctgtggc ggaacttcct ctacgcgaac gtggcgctgt acctgcccga ctcctacaag 20760

tacacgccgg ccaacatcac gctgccgacc aacaccaaca cctacgatta catgaacggc 20820

cgcgtggtgg cgccctcgct ggtggacgcc tacatcaaca tcggggcgcg ctggtcgctg 20880

gaccccatgg acaacgtcaa ccccttcaac caccaccgca acgcgggcct gcgctaccgc 20940

tccatgctcc tgggcaacgg gcgctacgtg cccttccaca tccaggtgcc ccaaaagttt 21000

ttcgccatca agagcctcct gctcctgccc gggtcctaca cctacgagtg gaacttccgc 21060

aaggacgtca acatgatcct gcagagctcc ctcggcaacg acctgcgcac ggacggggcc 21120

tccatcgcct tcaccagcat caacctctac gccaccttct tccccatggc gcacaacacc 21180

gcctccacgc tcgaggccat gctgcgcaac gacaccaacg accagtcctt caacgactac 21240

ctctcggcgg ccaacatgct ctaccccatc ccggccaacg ccaccaacgt gcccatctcc 21300

atcccctcgc gcaactgggc cgccttccgc ggatggtcct tcacgcgcct caagacccgc 21360

gagacgccct cgctcggctc cgggttcgac ccctacttcg tctactcggg ctccatcccc 21420

tacctcgacg gcaccttcta cctcaaccac accttcaaga aggtctccat caccttcgac 21480

tcctccgtca gctggcccgg caacgaccgc ctcctgacgc ccaacgagtt cgaaatcaag 21540

cgcaccgtcg acggagaggg atacaacgtg gcccagtgca acatgaccaa ggactggttc 21600

ctggtccaga tgctggccca ctacaacatc ggctaccagg gcttctacgt gcccgagggc 21660

tacaaggacc gcatgtactc cttcttccgc aacttccagc ccatgagccg ccaggtcgtg 21720

gacgaggtca actacaagga ctaccaggcc gtcaccctgg cctaccagca caacaactcg 21780

ggcttcgtcg gctacctcgc gcccaccatg cgccagggcc agccctaccc cgccaactac 21840

ccctacccgc tcatcggcaa gagcgccgtc gccagcgtca cccagaaaaa gttcctctgc 21900

gaccgggtca tgtggcgcat ccccttctcc agcaacttca tgtccatggg cgcgctcacc 21960

gacctcggcc agaacatgct ctacgccaac tccgcccacg cgctagacat gaatttcgaa 22020

gtcgacccca tggatgagtc cacccttctc tatgttgtct tcgaagtctt cgacgtcgtc 22080

cgagtgcacc agccccaccg cggcgtcatc gaggccgtct acctgcgcac gcccttctcg 22140

gccggcaacg ccaccaccta aagccccgct cttgcttctt gcaagatgac ggcctgtggc 22200

tccggcgagc aggagctcag ggccatcctc cgcgacctgg gctgcgggcc ctgcttcctg 22260

ggcaccttcg acaagcgctt cccgggattc atggccccgc acaagctggc ctgcgccatc 22320

gtcaacacgg ccggccgcga gaccgggggc gagcactggc tggccttcgc ctggaacccg 22380

cgctcccaca cctgctacct cttcgacccc ttcgggttct cggacgagcg cctcaagcag 22440

atctaccagt tcgagtacga gggcctgctg cgccgcagcg ccctggccac cgaggaccgc 22500

tgcatcaccc tggaaaagtc cacccagacc gtgcagggtc cgcgctcggc cgcctgcggg 22560

ctcttctgct gcatgttcct gcacgccttc gtgcactggc ccgaccgccc catggacaag 22620

aaccccacca tgaacttgct gacgggggtg cccaacggca tgctccagtc gccccaggtg 22680

gaacccaccc tgcgccgcaa ccaggaggcg ctctaccgct tcctcaacgc ccactccgcc 22740

tactttcgct cccaccgcgc gcgcatcgag aaggccaccg ccttcgaccg catgaatcaa 22800

gacatgtaaa ctgtgtgtat gtgaatgctt tattcatcat aataaacagc acatgtttat 22860

gccaccttct ctgaggctct gactttattt agaaatcgaa ggggttctgc cggctctcgg 22920

cgtgccccgc gggcagggat acgttgcgga actggtactt gggcagccac ttgaactcgg 22980

ggatcagcag cttcggcacg gggaggtcgg ggaacgagtc gctccacagc ttgcgcgtga 23040

gttgcagggc gcccagcagg tcgggcgcgg agatcttgaa atcgcagttg ggacccgcgt 23100

tctgcgcgcg agagttgcgg tacacggggt tgcagcactg gaacaccatc agggccgggt 23160

gcttcacgct cgccagcacc gtcgcgtcgg tgatgccctc cacgtccaga tcctcggcgt 23220

tggccatccc gaagggggtc atcttgcagg tctgccgccc catgctgggc acgcagccgg 23280

gcttgtggtt gcaatcgcag tgcaggggga tcagcatcat ctgagcctgc tcggagctca 23340

tgcccgggta catggccttc atgaaagcct ccagctggcg gaaggcctgc tgcgccttgc 23400

cgccctcggt gaagaagacc ccacaggact tgctagagaa ctggttggtg gcgcagcccg 23460

cgtcgtgcac gcagcagcgc gcgtcgttgt tggccagctg caccacgctg cgcccccagc 23520

ggttctgggt gatcttggcc cggtcggggt tctccttcag cgcgcgctgc ccgttctcgc 23580

tcgccacatc catctcgatc gtgtgctcct tctggatcat cacggtcccg tgcaggcacc 23640

gcagcttgcc ctcggcctcg gtgcacccgt gcagccacag cgcgcagccg gtgcactccc 23700

agttcttgtg ggcgatctgg gagtgcgagt gcacgaagcc ctgcaggaag cggcccatca 23760

tcgtggtcag ggtcttgttg ctggtgaagg tcagcgggat gccgcggtgc tcctcgttca 23820

catacaggtg gcagatgcgg cggtacacct cgccctgctc gggcatcagc tggaaggcgg 23880

acttcaggtc gctctccacg cggtaccgct ccatcagcag cgtcatcact tccatgccct 23940

tctcccaggc cgaaacgatc ggcaggctca gggggttctt caccgtcatc ttagtcgccg 24000

ccgccgaagt cagggggtcg ttctcgtcca gggtctcaaa cactcgcttg ccgtccttct 24060

cggtgatgcg cacggggggga aagctgaagc ccacggccgc cagctcctcc tcggcctgcc 24120

tttcgtcctc gctgtcctgg ctgatgtctt gcaaaggcac atgcttggtc ttgcggggtt 24180

tctttttggg cggcagaggc ggcggcggag acgtgctggg cgagcgcgag ttctcgctca 24240

ccacgactat ttcttcttct tggccgtcgt ccgagaccac gcggcggtag gcatgcctct 24300

tctggggcag aggcggaggc gacgggctct cgcggttcgg cgggcggctg gcagagcccc 24360

ttccgcgttc gggggtgcgc tcctggcggc gctgctctga ctgacttcct ccgcggccgg 24420

ccattgtgtt ctcctaggga gcaacaagca tggagactca gccatcgtcg ccaacatcgc 24480

catctgcccc cgccgccgac gagaaccagc agcagcagaa tgaaagctta accgccccgc 24540

cgcccagccc cacctccgac gccgccgcgg ccccagacat gcaagagatg gaggaatcca 24600

tcgagattga cctgggctac gtgacgcccg cggagcacga ggaggagctg gcagcgcgct 24660

tttcagcccc ggaagagaac caccaagagc agccagagca ggaagcagag agcgagcagc 24720

agcaggctgg gctcgagcat ggcgactacc tgagcggggc agaggacgtg ctcatcaagc 24780

atctggcccg ccaaagcatc atcgtcaagg acgcgctgct cgaccgcgcc gaggtgcccc 24840

tcagcgtggc ggagctcagc cgcgcctacg agcgcaacct cttctcgccg cgcgtgcccc 24900

ccaagcgcca gcccaacggc acctgcgagc ccaacccgcg cctcaacttc tacccggtct 24960

tcgcggtgcc cgaggccctg gccacctacc acctcttttt caagaaccaa aggatccccg 25020

tctcctgccg cgccaaccgc acccgcgccg acgccctgct caacctgggt cccggcgccc 25080

gcctacctga tatcacctcc ttggaagagg ttcccaagat cttcgagggt ctgggcagcg 25140

acgagactcg ggccgcgaac gctctgcaag gaagcggaga ggagcatgag caccacagcg 25200

ccctggtgga gttggaaggc gacaacgcgc gcctggcggt gctcaagcgc acggtcgagc 25260

tgacccactt cgcctacccg gcgctcaacc tgcccccccaa ggtcatgagc gccgtcatgg 25320

accaggtgct catcaagcgc gcctcgcccc tctcagagga ggagatgcag gaccccgaga 25380

gctcggacga gggcaagccc gtggtcagcg acgagcagct ggcgcgctgg ctgggagcga 25440

gcagcacccc ccagagcctg gaagagcggc gcaagctcat gatggccgtg gtcctggtga 25500

ccgtggagct ggagtgtctg cgccgcttct tcgccgacgc ggagaccctg cgcaaggtcg 25560

aggagaacct gcactacctc ttcaggcacg ggttcgtgcg ccaggcctgc aagatctcca 25620

acgtggagct gaccaacctg gtctcctaca tgggcatcct gcacgagaac cgcctggggc 25680

agaacgtgct gcacaccacc ctgcgcgggg aggcccgccg cgactacatc cgcgactgcg 25740

tctacctgta cctctgccac acctggcaga cgggcatggg cgtgtggcag cagtgcctgg 25800

aggagcagaa cctgaaagag ctctgcaagc tcctgcagaa gaacctcaag gccctgtgga 25860

ccgggttcga cgagcgcacc accgcctcgg acctggccga cctcatcttc cccgagcgcc 25920

tgcggctgac gctgcgcaac gggctgcccg actttatgag ccaaagcatg ttgcaaaact 25980

ttcgctcttt catcctcgaa cgctccggga tcctgcccgc cacctgctcc gcactgccct 26040

cggacttcgt gccgctgacc ttccgcgagt gccccccgcc gctctggagc cactgctact 26100

tgctgcgcct ggccaactac ctggcctacc actcggacgt gatcgaggac gtcagcagcg 26160

agggtctgct cgagtgccac tgccgctgca acctctgcac gccgcaccgc tccttggcct 26220

gcaaccccca gctgctgagc gagacccaga tcatcggcac cttcgagttg caaggccccg 26280

gcgagggcaa ggggggtctc aaactcaccc cggggctgtg gacctcggcc tacttgcgca 26340

agttcgtgcc cgaggactac catcccttcg agatcaggtt ctacgaggac caatcccagc 26400

cgcccaaggc cgagctgtcg gcctgcgtca tcacccaggg ggccatcctg gcccaattgc 26460

aagccatcca gaaatcccgc caagaatttc tgctgaaaaa gggccacggg gtctacttgg 26520

acccccagac cggagaggag ctcaacccca gcttccccca ggatgccccg aggaagcagc 26580

aagaagctga aagtggagct gccgctgccg ccggaggatt tggaggaaga ctgggagagc 26640

agtcaggcag aggagatgga agactgggac agcactcagg cagaggagga cagcctgcaa 26700

gacagtctgg aggaggaaga cgaggtggag gaggaggcag aggaagaagc agccgccgcc 26760

agaccgtcgt cctcggcgga ggagaaagca agcagcacgg ataccatctc cgctccgggt 26820

cggggtcgcg gcggccgggc ccacagtaga tgggacgaga ccgggcgctt cccgaacccc 26880

accacccaga ccggtaagaa ggagcggcag ggatacaagt cctggcgggg gcacaaaaac 26940

gccatcgtct cctgcttgca agcctgcggg ggcaacatct ccttcacccg gcgctacctg 27000

ctcttccacc gcggggtgaa cttccccccgc aacatcttgc attactaccg tcacctccac 27060

agcccctact actgtttcca agaagaggca gaaacccagc agcagcagca gaaaaccagc 27120

ggcagcagca gcagctagaa aatccacagc ggcggcaggt ggactgagga tcgcggcgaa 27180

cgagccggcg cagacccggg agctgaggaa ccggatcttt cccaccctct atgccatctt 27240

ccagcagagt cgggggcagg agcaggaact gaaagtcaag aaccgttctc tgcgctcgct 27300

cacccgcagt tgtctgtatc acaagagcga agaccaactt cagcgcactc tcgaggacgc 27360

cgaggctctc ttcaacaagt actgcgcgct cactcttaaa gagtagcccg cgcccgccca 27420

cacacggaaa aaggcgggaa ttacgtcacc acctgcgccc ttcgcccgac catcatcatg 27480

agcaaagaga ttcccacgcc ttacatgtgg agctaccagc cccagatggg cctggccgcc 27540

ggcgccgccc aggactactc cacccgcatg aactggctca gtgccgggcc cgcgatgatc 27600

tcacgggtga atgacatccg cgcccaccga aaccagatac tcctagaaca gtcagcgatc 27660

accgccacgc cccgccatca ccttaatccg cgtaattggc ccgccgccct ggtgtaccag 27720

gaaattcccc agcccacgac cgtactactt ccgcgagacg cccaggccga agtccagctg 27780

actaactcag gtgtccagct ggccggcggc gccgccctgt gtcgtcaccg ccccgctcag 27840

ggtataaagc ggctggtgat ccgaggcaga ggcacacagc tcaacgacga ggtggtgagc 27900

tcttcgctgg gtctgcgacc tgacggagtc ttccaactcg ccggatcggg gagatcttcc 27960

ttcacgcctc gtcaggccgt cctgactttg gagagttcgt cctcgcagcc ccgctcgggc 28020

ggcatcggca ctctccagtt cgtggaggag ttcactccct cggtctactt caaccccttc 28080

tccggctccc ccggccacta cccggacgag ttcatcccga acttcgacgc catcagcgag 28140

tcggtggacg gctacgattg aatgtcccat ggtggcgcgg ctgacctagc tcggcttcga 28200

cacctggacc actgccgccg cttccgctgc ttcgctcggg atctcgccga gtttgcctac 28260

tttgagctgc ccgaggagca ccctcagggc ccggcccacg gagtgcggat cgtcgtcgaa 28320

gggggcctcg actcccacct gcttcggatt ttcagccagc gtccgatcct ggtcgagcgc 28380

gagcaaggac agacccttct gaccctgtac tgcatctgca accaccccgg cctgcatgaa 28440

agtctttgtt gtctgctgtg tactgagtat aataaaagct gagatcagcg actactccgg 28500

actcgattgt ggtgttcctg ctatcaaccg gtccctgttc ttcaccggga acgagaccga 28560

gctccagctc cagtgtaagc cccacaagaa gtatctcacc tggctgttcc agggctctcc 28620

gatcgccgtt gtcaaccact gcgacaacga cggagtcctg ctgagcggcc ctgccaacct 28680

tactttttcc acccgcagaa gcaagctcca gctcttccaa cccttcctcc ccgggaccta 28740

tcagtgcgtc tcgggaccct gccatcacac cttccacctg atcccgaata ccacagcgcc 28800

gctccccgct actaacaacc aaactaccca ccaacgccac cgtcgcgacc tttctgaatc 28860

taatactacc acccacaccg gaggtgagct ccgaggtcga ccaacctctg ggatttacta 28920

cggggttaac cacgtggtta ctatgtcctt ccgagtgaga gacacaaaaa attccaacac 28980

actattgcaa tgaaaataaa tttcctttat tagccagaag tcagatgctc aaggggcttc 29040

atgatgtccc cataattttt ggcagaggga aaaagatctc catggcctag gtctagatta 29100

ggcggagctt aaatagccca tcacacgatt gatggtcacc acacgagtgc tgaaggcgtg 29160

cagtaaaatg cacagcttca tcttgacacg ataagggtca gcctctccca cggggggctt 29220

ctgtcttaaa gtctcgccgt tgtggttgag ggactgcatc agttcgtcga tggccaccag 29280

catgcccttg tctaaaatga tctgctggtg gttgtggttc tgtaaagcgg cattgatagc 29340

ttggaactcg gtctggtaca tctttaaatc ttcgtagatg ctgcccagac ataaagtcat 29400

cattaaagag gtcttctggg ggggtaaaca agagcctctt gtggtggagc tggtctcacg 29460

agtggctaaa cagctctcgt tcttgtgcag ctccagaggt aaacaagtct tcagtgtgct 29520

ggtctggtca cgagtgatgt cctcgtggtc gatatcctcg gcggtgcagc tgtagtgctt 29580

gagcttctca cgagcggtct tcaccatgtc gtcggtggtc ttcagcagat tacgagactg 29640

gcttaaacac ctagcggggc cgctaacggg gatcactctg gctaaagata aatggttcag 29700

taaagctaaa gtggctaaaa acagtaaata tctgctctgg cacatggggc caggattaga 29760

ctcgacgtcg ccagcgagct tgaggagatc aaagttcaga gtctgcttga cggacctcac 29820

cctacaaggc acacaagccc acttgctgca gctgctgttg tagtaacgat cttgagcttg 29880

cacgcacaca ttgccgccct tacactgcac ctcggtgctg gtcttctcca ccagaaaggc 29940

gcccttctgg ttgcagcctt cctcggtctc cttcatcttc tccttcttcc tctggatcct 30000

cacgaaaaac tttaaagaga agtaggagtg gggggtggac cagctatcgg ggtactccca 30060

gctcacctca acttgggagt tcttgagggg cttcatctgc agattcttgg ggggatcggg 30120

cttgataatg tctctgataa agaagcttgt ggagtaattc tcgtacttgt tctgctgacg 30180

agcctctaaa gccagttcga tgggtaaagt ctcctcagcg gtaggacaag tgacgtcttc 30240

ttggcagctc acgctgtact tctcgtagtc cctctggtcg agggtcacct tctcggcgga 30300

taaagaggcc atgccacatg tcacggcacg agagtcgggg ctgctgctgg agctcttgat 30360

attgaacttt aaatccatat tcctctggac cagccaagaa caagtaaaac gaccggagta 30420

gttgggggcc tcgcacttta aaaaggtctt gttcttgaaa ttcttgagga tctctgtgct 30480

ccagatgccg ttctccttct tgtgcagcag taaatgggag tggctgagtg tctcgccgcc 30540

tttgtgacaa gtatactggc cggcatcgag gaactccttc acggtgatgg ttaaagtctt 30600

gccggagccg atcacgccgt gtctctgatc gctggtccaa gtgatgtcgt cctcttcggg 30660

ggtgtcacaa gttaaattca cggtttcgcc gggggcatcg ggtgtccagt ccacctccac 30720

gacgtacaca tccttctcca gctcccacat ggccattaaa ggggagacca gcagcacgat 30780

ggcaaaccag ctgatggtca gcttctgggg gcacatggtc ctaggctgtt cgtcacccag 30840

gacctggcta gcctgcccag tgcctcacga ccaacttctg cagcttaagt tcgagactgt 30900

tgtgtcagaa gcactgactg cgttagcaat ttaactgtga taaactaccg caataaagct 30960

tgctcccgcc cgccgcgcgc ttcgcttttt atagggccgc cgccgccgcc gcctcgccat 31020

aaaaggaaac tttcggagcg cgccgctctg attggctgcc gccgcacctc tccgcctcgc 31080

cccgccccgc ccctcgcccc gccccgcccc gcctggcgcg cgcccccccc ccccgccccc 31140

atcgctgcac aaaataatta aaaaataaat aaatacaaaa ttgggggtgg ggaggggggg 31200

gagatgggga gagtgaagca gaacgtgggg atccgcgatc cattaattaa ggggattcca 31260

tatggtacgt acatcgcctc tcctacgagc tcctgcagca gcgccagaag ttcacctgcc 31320

tggtcggagt caaccccatc gtcatcaccc agcagtcggg cgataccaag gggtgcatcc 31380

actgctcctg cgactccccc gactgcgtcc acactctgat caagaccctc tgcggcctcc 31440

gcgacctcct ccccatgaac taatcacccc cttatccagt gaaataaaga tcatattgat 31500

gatgatttta cagaaataaa gatacaatca tattgatgat ttgagtttaa taaaaaataa 31560

agaatcactt acttgaaatc tgataccagg tctctgtcca tgttttctgc caacaccact 31620

tcactcccct cttcccagct ctggtactgc aggccccggc gggctgcaaa cttcctccac 31680

acgctgaagg ggatgtcaaa ttcctcctgt ccctcaatct tcattttatc ttctatcaga 31740

tgtccaaaaa gcgcgtccgg gtggatgatg acttcgaccc cgtctacccc tacgatgcag 31800

acaacgcacc gaccgtgccc ttcatcaacc cccccttcgt ctcttcagat ggattccaag 31860

agaagcccct gggggtgctg tccctgcgac tggccgaccc cgtcaccacc aagaacgggg 31920

aaatcaccct caagctggga gagggggtgg acctcgactc ctcgggaaaa ctcatctcca 31980

acacggccac caaggccgcc gcccctctca gtttttccaa caacaccatt tcccttaaca 32040

tggatcaccc cttttacact aaagatggaa aattatcctt acaagtttct ccaccattaa 32100

atatactgag aacaagcatt ctaaacacac tagctttagg ttttggatca ggtttaggac 32160

tccgtggctc tgccttggca gtacagttag tctctccact tacatttgat actgatggaa 32220

acataaagct taccttagac agaggtttgc atgttacaac aggagatgca attgaaagca 32280

acataagctg ggctaaaggt ttaaaatttg aagatggagc catagcaacc aacattggaa 32340

atgggttaga gtttggaagc agtagtacag aaacaggtgt tgatgatgct tacccaatcc 32400

aagttaaact tggatctggc cttagctttg acagtacagg agccataatg gctggtaaca 32460

aagaagacga taaactcact ttgtggacaa cacctgatcc atcgccaaac tgtcaaatac 32520

tcgcagaaaa tgatgcaaaa ctaacacttt gcttgactaa atgtggtagt caaatactgg 32580

ccactgtgtc agtcttagtt gtaggaagtg gaaacctaaa ccccattact ggcaccgtaa 32640

gcagtgctca ggtgtttcta cgttttgatg caaacggtgt tcttttaaca gaacattcta 32700

cactaaaaaa atactggggg tataggcagg gagatagcat agatggcact ccatatacca 32760

atgctgtagg attcatgccc aatttaaaag cttatccaaa gtcacaaagt tctactacta 32820

aaaataatat agtagggcaa gtatacatga atggagatgt ttcaaaacct atgcttctca 32880

ctataaccct caatggtact gatgacagca acagtacata ttcaatgtca ttttcataca 32940

cctggactaa tggaagctat gttggagcaa catttggggc taactcttat accttctcat 33000

acatcgccca agaatgaaca ctgtatccca ccctgcatgc caacccttcc caccccactc 33060

tgtggaaaaa actctgaaac acaaaataaa ataaagttca agtgttttat tgattcaaca 33120

gttttacagg attcgagcag ttatttttcc tccaccctcc caggacatgg aatacaccac 33180

cctctccccc cgcacagcct tgaacatctg aacgccattg gtgatggaca tgcttttggt 33240

ctccacgttc cacacagttt cagagcgagc cagtctcggg tcggtcaggg agatgaaacc 33300

ctccgggcac aattgggaga agtactcgcc tattatctgg aagaagcaga agagcggcgg 33360

tgggaatcat agtccgcgaa cgggatcggc cggtggtgtc gcatcaggcc ccgcagcagt 33420

cgctgccgcc gccgctccgt caagctgctg ctcagggggt ccgggtccag ggactccctc 33480

agcatgatgc ccacggccct cagcatcagt cgtctggtgc ggcgggcgca gcagcgcatg 33540

cggatctcgc tcaggtcgct gcagtacgtg caacacagaa ccaccaggtt gttcaacagt 33600

ccatagttca acacgctcca gccgaaactc atcgcgggaa ggatgctacc cacgtggccg 33660

tcgtaccaga tcctcaggta aatcaagtgg tgccccctcc agaacacgct gcccacgtac 33720

atgatctcct tgggcatgtg gcggttcacc acctcccggt accacatcac cctctggttg 33780

aacatgcagc cccggatgat cctgcggaac cacagggcca gcaccgcccc gcccgccatg 33840

cagcgaagag accccgggtc ccggcaatgg caatggagga cccaccgctc gtacccgtgg 33900

atcatctggg agctgaacaa gtctatgttg gcacagcaca ggcatatgct catgcatctc 33960

ttcagcactc tcaactcctc gggggtcaaa accatatccc agggcacggg gaactcttgc 34020

aggacagcga accccgcaga acagggcaat cctcgcacag aacttacatt gtgcatggac 34080

agggtatcgc aatcaggcag caccgggtga tcctccacca gagaagcgcg ggtctcggtc 34140

tcctcacagc gtggtaaggg ggccggccga tacgggtgat ggcgggacgc ggctgatcgt 34200

gttcgcgacc gtgtcatgat gcagttgctt tcggacatat ttcctgaagt cttggcgcgc 34260

caaagtctag acagcgtcca tagcttaccg agcagcagca gcagcacaca acaggcgcaa 34320

gagtcagaga aaggctgagc tctaacctgt ccacccgctc tctgctcaat atatagccca 34380

gatctacact gacgtaaagg ccaaagtcta aaaatacccg ccaaatagtc acacacgccc 34440

agcacacgcc cagaaaccgg tgacacactc aaaaaaatac gcgcacttcc tcaaacgccc 34500

aaactgccgt catttccggg ttcccacgct acgtcatcaa aacacgactt tcaaattccg 34560

tcgaccgtta aaaacgtcac ccgccccgcc cctaacggtc gcccgtctct cagccaatca 34620

gcgccccgca tccccaaatt caaacacctc atttgcatat taacgcgcac caaaagtttg 34680

aggtatatta ttgatgatga ttt 34703

Claims (8)

1. A therapeutic HPV vaccine is characterized in that the therapeutic HPV vaccine is an HPV recombinant adenovirus vaccine with immunogenicity obtained by packaging and processing HPV vaccine vector plasmids, wherein the HPV vaccine vector is a replication-defective chimpanzee adenovirus vector;

the therapeutic HPV vaccine encodes the E6, E7 proteins of the HPV virus;

the HPV viruses comprise HPV type 16and HPV type 18;

the amino acid sequence of the HPV16-E6 protein is SEQ ID NO. 1, the amino acid sequence of the HPV16-E7 protein is SEQ ID NO. 2, the amino acid sequence of the HPV18-E6 protein is SEQ ID NO. 3, and the amino acid sequence of the HPV18-E7 antigen is SEQ ID NO. 4;

the therapeutic HPV vaccine further encodes an IL-12 or GM-CSF cytokine.

2. The therapeutic HPV vaccine according to claim 1 characterised in that the amino acid sequence of the HPV16 type E6 or E7 protein is linked to the amino acid sequence of the HPV18 type E6 or E7 protein by a linker sequence P2A, the P2A sequence is SEQ ID NO 5;

the amino acid sequences of the E6 and E7 proteins of HPV16 are connected through a connecting sequence F2A, the amino acid sequences of the E6 and E7 proteins of HPV18 are connected through a connecting sequence F2A, and the sequence F2A is SEQ ID NO 6.

3. The therapeutic HPV vaccine of claim 2, wherein HPV16-E6, HPV16-E7, HPV18-E6 and HPV18-E7 are joined by the joining sequences P2A and F2A to form a fusion protein HPV 16/18-E6/E7; the amino acid sequence of the HPV16/18-E6/E7 is SEQ ID NO 7, and the DNA sequence designed after codon optimization of the sequence is SEQ ID NO 8.

4. The therapeutic HPV vaccine of claim 3, wherein the replication-defective chimpanzee adenovirus vector has a genomic sequence wherein an open reading frame sequence comprising HPV16/18-E6/E7 genes is inserted between the Δ E1 sites MluI and EcoRI.

5. The therapeutic HPV vaccine according to claim 4, wherein the replication deficient chimpanzee adenovirus vector has a genomic sequence with an inserted open reading frame sequence comprising the murine GM-CSF or IL-12 gene between HpaI and PacI at Δ E3.

6. The therapeutic HPV vaccine of claim 1, wherein the replication-defective chimpanzee adenovirus vector is a chimpanzee adenovirus replication-defective type 63 or type 3 adenovirus.

7. A method for the preparation of a therapeutic HPV vaccine according to any one of claims 1-6, characterised in that it comprises the steps of:

1) the chimpanzee adenovirus replication-defective type 63 or type 3 adenovirus is selected as a model virus vector, and E6 and E7 of HPV16 and HPV18 are selected as model antigens;

2) inserting the nucleotide sequences of E6 and E7 antigen proteins of the coded HPV16 and HPV18 alone or together with the nucleotide sequence of a murine cytokine IL-12/GM-CSF into a model virus vector plasmid to construct a recombinant plasmid;

3) after enzyme digestion linearization, the recombinant plasmid is transfected into adenovirus packaging cells, and the cells are cultured until 80% of the cells have obvious cytopathic effect;

4) collecting cells, breaking the cells by adopting a repeated freeze thawing mode, and centrifugally collecting supernate;

5) infecting adenovirus packaging cells with the supernatant, and culturing until the cells change from adherent to suspension state;

6) repeatedly performing amplification culture to a certain volume according to the steps 3) and 4), collecting cells, crushing, centrifuging, and taking supernate;

7) and (3) purifying the recombinant adenovirus by taking the supernatant to obtain virus liquid, wherein the virus liquid is the therapeutic HPV vaccine stock solution.

8. Use of a therapeutic HPV vaccine according to any one of claims 1-6 for the manufacture of a medicament or kit for the prevention or treatment of an HPV related disease.

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