[go: up one dir, main page]

CN114615889A - Pesticide composition and method for producing same - Google Patents

Pesticide composition and method for producing same Download PDF

Info

Publication number
CN114615889A
CN114615889A CN202080075301.4A CN202080075301A CN114615889A CN 114615889 A CN114615889 A CN 114615889A CN 202080075301 A CN202080075301 A CN 202080075301A CN 114615889 A CN114615889 A CN 114615889A
Authority
CN
China
Prior art keywords
parts
water
ethyl
methyl
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080075301.4A
Other languages
Chinese (zh)
Inventor
冈田优也
巽大喜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kumiai Chemical Industry Co Ltd
Original Assignee
Kumiai Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kumiai Chemical Industry Co Ltd filed Critical Kumiai Chemical Industry Co Ltd
Priority to CN202510976717.8A priority Critical patent/CN120898801A/en
Publication of CN114615889A publication Critical patent/CN114615889A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

本发明提供一种使用水溶性聚合物的促进农药活性成分溶出的技术。本发明为一种农药组合物及其制造方法，所述农药组合物的特征在于，含有体积中值粒径小于1μm的农药活性成分的晶粒和水溶性聚合物。The present invention provides a technology for promoting the dissolution of pesticide active ingredients using a water-soluble polymer. The present invention relates to a pesticide composition and a method for producing the same. The pesticide composition is characterized in that it contains crystal grains of pesticide active ingredients with a volume median diameter of less than 1 μm and a water-soluble polymer.

Description

Pesticide composition and method for producing same
Technical Field
The present invention relates to a pesticide composition and a granular pesticide preparation having improved elution of a pesticide active ingredient, and to methods for producing the same.
Background
The pesticidal active ingredient contained in the pesticidal composition needs to be controlled and promoted to be eluted depending on various purposes.
As a means for controlling the elution of an active ingredient of an agricultural chemical, for example: means for processing the agricultural chemical active ingredient itself, such as microencapsulation described in patent document 1 and the like, or powdering of a sustained-release raw material described in patent document 2 and the like, and means having an elution controlling performance structurally, such as hydrophobic substance-coated granules described in patent document 3 and the like, or hydrophobic substance-containing granules described in patent document 4 and the like. However, the former two are accompanied by special processing steps, and therefore, the cost increase is inevitable, and the latter two are premised on the formation of a coating structure or a matrix structure of a hydrophobic substance, and therefore, the application range thereof is inevitably limited to granular agricultural chemicals that do not disintegrate in water.
On the other hand, water-soluble polymers such as polyvinylpyrrolidone are widely known and are mainly used as physical conditioning aids such as binders and disintegrants in the field of agricultural chemicals, and patent document 5 describes that it has an effect of preventing decomposition of a specific agricultural chemical active ingredient. Further, patent document 6 discloses that it has an effect of reducing phytotoxicity on useful plants derived from alkylbenzenesulfonic acids as a surfactant contained in an aqueous preparation. Further, patent document 7 filed by the present applicant discloses that it can control benzenesulfonic acid
Figure BDA0003617497470000011
The pennisetum flaccidum (fenoxasulfone) can be dissolved out in water to preventThe occurrence of phytotoxicity accompanied with local concentration increase is prevented.
However, it has not been known that a water-soluble polymer such as polyvinylpyrrolidone can promote the elution property of an active ingredient of an agricultural chemical.
Documents of the prior art
Patent document
Patent document 1: japanese patent laid-open publication No. 2004-103481
Patent document 2: japanese laid-open patent publication No. 8-92497
Patent document 3: japanese laid-open patent publication No. 10-25202
Patent document 4: japanese patent laid-open No. 2000-26206
Patent document 5: japanese laid-open patent publication No. 5-320010
Patent document 6: japanese patent laid-open publication No. 2014-196253
Patent document 7: japanese patent laid-open publication No. 2019-19062
Disclosure of Invention
Problems to be solved by the invention
Accordingly, an object of the present invention is to provide a technique for promoting elution of an agricultural chemical active ingredient using a water-soluble polymer.
Means for solving the problems
The present inventors have conducted intensive studies to solve the above problems and as a result, have found that the dissolution of an agricultural chemical active ingredient can be promoted by reducing the volume median particle diameter of the agricultural chemical active ingredient combined with a water-soluble polymer, thereby completing the present invention.
That is, the present invention is a pesticidal composition characterized by containing a crystal grain of a pesticidal active ingredient having a volume median particle diameter of less than 1 μm and a water-soluble polymer.
The present invention is also a method for producing an agricultural chemical composition, comprising the steps of: a step of pulverizing the crystal grains of the agricultural chemical active ingredient to a volume median diameter of less than 1 μm; and a step of mixing the crystal grains of the pesticidal active ingredient with the water-soluble polymer before or after the pulverization step.
Effects of the invention
The agricultural chemical composition of the present invention promotes the dissolution of the agricultural chemical active ingredient by a simple technique of reducing the volume median diameter of the grains of the agricultural chemical active ingredient. Therefore, the compound can be widely applied to herbicides, plant regulators (plant growth regulators), insecticides, bactericides and the like.
The method for producing the pesticidal composition of the present invention is simple and convenient because no special step is used except the step of reducing the volume median diameter of the grains of the pesticidal active ingredient.
Detailed Description
The pesticidal composition of the present invention (hereinafter referred to as "the present composition") contains grains of the pesticidal active ingredient having a volume median particle diameter of less than 1 μm, preferably 0.2 to 0.8 μm, and a water-soluble polymer. In the present specification, the volume median diameter is a diameter in which the volume of a larger side and a smaller side is equal when a powder is divided into two parts from a certain particle diameter on the basis of the volume. The volume median particle diameter is determined as a median particle diameter of a volume particle size distribution measured by a laser analysis type particle size distribution measuring apparatus, for example.
The pesticidal active ingredient used in the composition of the present invention is not particularly limited as long as it is crystalline. Examples thereof include, but are not limited to, the following examples. These pesticidal active ingredients may be used in 1 kind or in combination of 2 or more kinds.
[ insecticidal active ingredient ]
Fluthrin (acrinathrin), azadirachtin (azadirachtin), picoline
Figure BDA0003617497470000031
Phosphorus (azamethiphos), acephate (azinphos-ethyl), baphate (azinphos-methyl), acequinome (acequinome), acetamiprid (aceprid), acetoprole (acetoprole), acephate (acephate), azocyclotin (azocyclotin), abamectin (abamectin), Afidopyropen (Aforamide), alfurane (afoxoolaner), sulfadiazine (amidoflumet), amitraz (amitraz), gossypol (alanycarb), aldicarb (aldicarb), allethrin (allethrin) [ including d-cis-trans-type, d-trans-type [ ]]Chlorazol phosphas, Isamidofos, isocarbophos,
Figure BDA0003617497470000032
Triazophos (isoxathion), isothiophos (isofenphos-methyl), isoprocarb (isoprocarb), ivermectin (ivermectin), neonicotinate (iminofenphos), imidacloprid (imidacloprid), climethrin (imiprothrin), indoxacarb (indoxacarb), S-fenvalerate (esfenvalerate), ethiofencarb (ethiofencarb), ethiofencarb (ethion), ethiprole (ethiprole), dibromoethane (ethlene dibromide), etoxazole (etoxazole), ethofenprox (ethofenprox), ethoprophos (ethoprophos), ethirimos (ethimfos), emamectin benzoate (emamectin benzoate), endosulfan (endosulfan), dexethofenprox (ethofenprox), oxfenthiofenthiocarb (ethiofenprox), thiofenthiocarb (ethiofenprox), thiocarb (ethiofenprox), thiocarb (carb), thiocarb (thiocarb), thiocarb (carb (thiocarb), thiocarb (thiocarb-methofen), thiocarb (carb), thiocarb (carb (thiocarb), thiocarb (thiocarb), thiocarb (thiocarb), thiocarb (thiocarb), thiocarb (thiocarb), thiocarb (thiocarb), thiocarb (thiocarb), thiocarb (thiocarb), thiocarb (thiocarb), thiocarb (thiocarb-thiocarb (thiocarb), thiocarb (thiocarb), thiocarb (thiocarb), thiocarb-methyl-thiocarb), thiocarb-thio, Carbofuran (carbofuran), lindane (gamma-BHC), propoxycarb (xylcarb), quinalphos (quinalphos), methoprene (kinoprene), chlorfenapyr (chinomethionat), coumaphos (coumaphos), cryolite (cryolite), clothianidin (clothianidin), clofentezine (clofenezine), chromafenozide (chromafenozide), chlorantraniliprole (chlorantraniliprole), chlorophenoxyphos (chlorethoxyfos), chlordane (chloredanane), chloropicrin (chlorepicrin), chlorpyrifos (chlorpyrifos-methyl), chlorfenapyr (chlorpyrifos), chlorfenapyr (chlorentrol), chlorpyrifos (chlorpyrifos-methyl), chlorfenapyr (chlorpyrifos), chlorpyrifos (chlorpyrifos), fenthion (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyrifos), chlorpyrifos (chlorpyri, Dichlorvos, diclomezotiaz, 1, 3-D.D. mix (1,3-dichloropropene), dicofol, dicyclanilDisulfoton (disulfoton), dinotefuran (dinotefuran), dinotefuran (dinobuton), cyhalodiamide (cyhalodiamide), cyhalothrin (cyhalothrin) [ including gamma-type, lambda-type]Cyphenothrin [ including (1R) -trans-type ]]Cyfluthrin including beta-type]Diflubenzuron (diflubenzuron), cyflumetofen (cyflumetofen), flutenzine (difluovidazin), cyhexatin (cyhexatin), cypermethrin (cypermethrin) [ including alpha-, beta-, theta-, zeta-type]Examples of such agents include methoprene (dimethylvinphos), tetramethrin (dimefluthrin), dimethoate (dimerate), silafluofen (silaflufen), cyromazine (cyromazine), spinetoram (spinetoram), spinosad (spinosad), spirodiclofen (spirodiclofen), spirotetramat (spirotetramat), spirotetramat (spiromesifen), sodium sulfophenoxide (sulfenoxuron-sodium), flubenemid (sulfflunomide), sulfoxaflor (sulfluramid), sulfopyrad (sulfluramid), sulforaphane (sulfofenphos), diazinon (diazinon), thiacloprid (thiacloprid), thiamethoxam (thiamethoxam), tioazafen (thiodicarb), thiocarb (thiodicaffe), thiocyclam (thiophosphor), teflufen (thiamethoxam), tefluthrin (thiamethoxam), teflufen (thiamethoxam), tebufenm (thiodicarb), thiocyclam (thiophosphor), tebufenozide (thiamine (tebufenozide), teflufen (thiamine (thiamethoxam), tebufenozide), teflufen (thiofen), tebufenofen), tebufenozide (tebufenozide), tebufenozide (tebufenofos (tebufenozide), tebufenofos (teflufen), tebufenofos (teflufen), teflufen (teflufen), teflufen (teflufen), teflufen (teflufen), teflufen (teflufen), teflufen (teflufen), teflufen (teflufen), teflufen (teflufen), teflufen (teflufen), teflufen (teflufen), teflufen (teflufen), teflufen (teflu, Florfenicol (teflubenzuron), demeton-S-methyl, temephos (temephos), deltamethrin (deltamethrin), terbufos (terbufos), tralomethrin (tralomethrin), transfluthrin (transfluthrin), triazamate (triazamate), triazophos (triazophos), trichlorfon (trichlorfon), triflumuron (triflumuron), triflumylpyrimidine (triflumylpyrimidine), triazamate (trimethacarb), tolfenpyrad (tolfenpyrad), dibromophosphorus (naled), nitenpyram (nitenpyram), novaluron (novaluron), Verticillium (Verticillium), ethyene (diethylphenate), thiobacillus punctatus (thioptera), thiobacillus punctatus (vampire), parathion (parathion), thiopyra (parathion), thiothiothiothiothion (methyl thion), thion (parathion-methyl thion), thion (thion-methyl thion), thion (thiothion (trimethophyton), thiothiothion (thion), thiothiothion (thiothiothion), thion (thiothiofenoxate (thiofenoxate), thiofenoxathion (thiofenoxathiofenoxate (thiofenoxate), thiofenoxathiofenoxathiofenoxate (thiofenoxathiofenoxathiofenoxathion), thiofenoxate (thion-methyl thion), thiofenoxathiofenoxathion-methyl thion), thiofenoxathiofenoxathiofenoxathion (thion-methyl thion), thion (thiofenoxathion), thiofenoxathion-methyl thion, thion-methyl thiofenoxathiofenoxathiofenoxathion, thiofenoxathiofenoxathion, thiofenoxathion, thiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathion, thiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathion, thiofenoxathion, thion, thiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathion, thiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathion, thiofenoxathion, thion, thiofenoxathiofenoxathiofenoxathiofenoxathion, thion, thiofenoxathiofenoxathiofenoxathion, thion, thiofenoxathiofenoxathion, thiofenoxathiofenoxathiofenoxathiofenoxathiofenoxa, thiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxa, thiofenoxathiofenoxathiofenoxathiofenoxa, thiofenoxathion, thiofenoxathiofenoxathiofenoxathiofenoxathion, thiofenoxathion, thiofenoxathiofenoxathiofenoxathion, thiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathion, thiofenoxathion, thioHydrazides (halofenozide), bioallethrin (bioallethrin), 2-cyclopentenyl bioallethrin (bioallethrin S-cyclopropenyl), bioresmethrin (bioresmethrin), diflubenzuron (bistrifluron), hydramethylnon (hydramethylnon), bifenazate (bifenazate), bifenthrin (bifenthrin), flukumide, synergistic ethers (piperonyl butoxide), pymetrozine (pymetrozine), pyrazofos (pyraclofos), pyraflupyrronil (pyraflupyrronil), pyridaphron (pyridaphronate), pyridaphenthrin (pyridaphron), pyridaphenthrin (pyridaphyluron), pyrifluquinazon, pyriproxyfen, pirimicarb (pyriproxyfen), pirimicarb (pirimicarb), pyriminofen (pyrimidifen), pyriminostrobin (pyriminostrobin), pirimiphos-methyl (pirimiphos-methyl), pyrethrin (pyrethine), famshur (famshur), fipronil (fipronil), fenazaquin (fenzaquin), fenamiphos (fenmiphos), fenitrothion (fenstrothion), fenoxycarb (fenoxycarb), fenoxycarb (fenothiocarbarb), phenothrin (phenothrin) [ including (1R) -trans-type.]Fenobucarb (fenobucarb), fenthion (fenthion), phenthoate (phenothoate), fenvalerate (fenvalate), fenpyroximate (fenpyroximate), fenbutatin oxide (fenbutatin oxide), fenpropathrin (fenpropathrin), fonofos (fonofos), sulfuryl fluoride (sulfofluoride), butocarb (butocarboxim), butoxycarb (butoxycarbxim), buprofezin (buprofazine), furathicarb (furathiocarb), prallethrin (prallethrin), fluacrypyr, triflumimide (fluazazoline), chlorfluazuron (fluazuron), diflufensulfone (fluxuetone), flurodium (sodium fluoride), sodium fluoroacetate (sodium fluoride), sodium flufenamate (flufenacet)
Figure BDA0003617497470000061
Azoloxamide (fluxamide), flucycloxuron (flucycloxuron), flucythrinate (flucythrinate), flusulfamide (fluusfamide), fluvalinate (fluvalinate) [ including tau-type]Flupyradifurone (flupyradifurone), Flupyrazofos (flupyrrazofos), Flupyrmin (flufiprole), pyriminostrobin (flufenerim), flufenacet (flufenoxystrobin), flufenoxuron (flufenoxuron), Fluhexafon (flubendiamide), flumethrin (fluethrin), Protrifenbute (prothiofos), propylbenzene tetramethrin (prothifenbut)e) Flonicamid (flonicamid), propaphos (propaphos), propargite (propageate), profenofos (profenofos), Broflinolide, proffluthrin (profluthrin), triacarb (propeetamphos), propoxur (propuxur), Flomoquinone, bromopropylate (bromopyrate), hexythiazox (hexythiazox), hexaflumuron (hexaflumuron), Paecilomyces tenuipes (Paecilomyces fumonis), Paecilomyces fumosoroseus (Paecilomyces fumonis), Heptaluthrin, heptenophos (heptenophos), permethrin (permethrin), Benclothiaz, sultap (bensultap), Benzoxite (benzoxime),
Figure BDA0003617497470000071
Bendiocarb (benfurocarb), benfuracarb (benfuracarb), Beauveria gracilis (Beauveria tenella), Beauveria bassiana (Beauveria bassiana), Beauveria bassiana (Beauveria brongniartii), phoxim (phoxim), phoxim (phoslong), fosthiazate (fosthiazate), thiophosphor (fosthiatan), phosphamide (phos), phosmet (phosmet), lipromycin (polynactin), vamidin (formamidate), phorate (phorate), malathion (malathion), milbemectin (milbemectin), triazophos (mecarbam), phosmet (mesulfenfos), methoprene (methoprene), methoprene (methomyl), methomyl (methomyl), metaflumethrin (methrin), methomyl (methomyl), methomyl (methomyl) and methomyl (methomyl) of), methomyl (methomyl), methomyl (methomyl), methomyl (methomyl), methomyl) of, methomyl (methomyl), methomyl (methomyl) of (methomyl), methomyl) of (methomyl) of (methomyl), methomyl (methomyl) of (methomyl), methomyl (methomyl ) of (methomyl), methomyl (methomyl, methomyl, Metolcarb, metocloprid, mevinphos, meperfluthrin, monacorophos phtomaphagum, monocrotophos, momflurothrin, Epsilon-momfluthrin, tollur-A, litlure-B, aluminum phosphide, zinc phosphide, phosphine phosphide, lufenuron, reslurre, reslurry reslurrin, lepimectin, rotenone, fenbutatin oxide, calcium cyanide, nicotine sulfatesulfote), (Z) -11-tetradecene ═ acetate, (Z) -11-hexadecene aldehyde, (Z) -11-hexadecene ═ acetate, (Z) -9, 12-tetradecadiene ═ acetate, (Z) -9-tetradecene-1-ol, (Z, E) -9, 11-tetradecadiene ═ acetate, (Z, E) -9, 12-tetradecadiene ═ acetate, Bacillus japonicus (Bacillus popilliae), Bacillus subtilis (Bacillus subtilis), Bacillus sphaericus (Bacillus sphaericus), Bacillus thuringiensis subspecies (Bacillus thuringiensis subspecies), Bacillus thuringiensis subspecies (Bacillus thuringiensis subspecies), Bacillus thuringiensis subspecies (Bacillus thuringiensis subspecies sp), Bacillus thuringiensis subspecies strain (Bacillus thuringiensis subspecies sp), Bacillus thuringiensis subspecies sp) Bt proteins (Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34/35Ab1), CL900167 (code), dichloroisopropyl ether (DCIP), dichlorodiphenyl oxide (DDT), dimethyl-2, 2, 2-trichloro-1-hydroxyethylphosphonate (DEP), Dinitrophenol (DNOC), O-diethyl-O- [4- (dimethylsulfamoyl) phenyl ] phosphonate]Phosphorothioate (DSP), thiophosphine (EPN), nuclear polyhedrosis virus encapsidate, NA-85 (code), NA-89 (code), NC-515 (code), RU15525 (code), XMC, Z-13-eicosen-10-one, ZXI8901 (code), (RS) -2-chloro-4-fluoro-5- [5- (trifluoromethylthio) pentyloxy]Phenyl-2, 2, 2-trifluoroethylsulfoxide (chemical name, CAS registry No. 1472050-04-6).
[ Bactericidal active ingredient ]
Epoxiconazole (azaconazole), activated ester (acibenzolar-S-methyl), azoxystrobin (azoxystrobin), trichlorfon (anilazine), amisulbrom (amisulbrom), ametoctadine (ametocida), aldimorph (aldimorph), isotianil (isotianil), isopyrazam (isopyrazam), iprothiamine (isofenamid), isoprothiolane (isoprothiolane), ipconazole (ipconazole), ipfentrothionazole (ipfenuron), iprodione (iprodione), moldavicarb (iprovalicarb), isoprothiolane (iprobenfonofos), imazazole (imazalil), iminoctadine-trioctylphonate (iminoctadine-trialatate), octoxydine acetate (iminoctadine-acetate), imazathiofamil (iprodione), imazalil (imazalil), iminoctadine (imazaprinil-S-methyl), pyrimethanil (imazathiofamil (imazalil), pyrimethanil (imazathiofamil) (imazalil), pyrimethanil (imazalin acetate (imazalil-E) (imazalil), pyrimethanil (imazalil) and pyrimethanil (imazalil) salts (imazalil), pyrimethanil (imazalil) are also, pyrimethanil (imazalil, pyrimethanil) salts, pyrimethanil (imazalil, pyrimethanil) and pyrimethanil (imazalil, pyrimethanil) or their salts, pyrimethanil (imazalils), pyrimethanil (imazalil, pyrimethanil (imazalils), pyrimethanil (imazalil (imazalils), pyribenil (imazalils), pyrimethanil (imab) or their salts, pyrimethanil (imazalils), pyribenil (imazabenil (imazalils), pyrimethanil (imazalils), pyribenil (imab) or pyribenil (imazalils), pyribenil (imab) or their salts, pyribenil (imazabenil (imab) or pyribenil (imazabenil (imab) or pyribenil (imab) or pyribenil (imab, pyribenil (imazabenil (imab) or pyribenil (imazabenil (imab)oxam), ethirimol (ethirimol), ethoxyquinoline (ethoxoquin), hymexazol (ethiodiazole), enestroburin (enestrobin), enoxabin, epoxiconazole (epoxiconazole), organic oils (organo oils),
Figure BDA0003617497470000091
Oxazizyl, Oxazinylazole, oxathidiazirine, oxycarboxin, oxine-copper, oxytetracycline, and mixtures thereof,
Figure BDA0003617497470000092
Imidazole (oxyponazole-fumarate), quinazone (oxolinic acid), copper octoate (copperdioctanoate), octhiolone (octhianone), furosemide (ofaracyne), orysastrobin (orysastrobin), o-phenylphenol (o-phenylphenol), kasugamycin (kasugamycin), captafol (captafol), cyclopropanamide (carpropamide), carbendazim (carbendazim), carboxin (carboxin), carvone (carbozine), phenoxyquinoline (quinoxyfen), Quinofumelin, mefenamic (chinomethionat), captan (captan), Quinconazole, quintozene (quintozene), dicaprylamine (guazate), thiofenamate (thiofenacethyl), eugenol (cyanothionine), metoclopramide (acetochlor), metoclopramide (clofenamidothionine (chlorpyrifos), metoclopramide (chlorpyrifos), chlorpyrifos (chlorpyrifos) and chlorpyrifos (chlorpyrifos) including, chlorpyrifos (chlorpyrifos) including, chlorpyrifos (chlorpyrifos, chlorpyrifos (chlorpyrifos, diniconazole (diniconazole), R-diniconazole (diniconazole-M), zineb (zineb), diniconic crotonate (dinocap), dipyrithron, diphenylamine (diphenylamine), difenoconazole (difenoconazole), cycloflubendiamide (cyflufenamid), fluopyram (diflumetorim), cyproconazole (cyproconazole), cyprodinil (cypropidin), simeconazole (simeconazole), dimetrimol (dimethicol), dimethyldisulfide (dimethomorph), dimethomorph (dimethomorph), cymoxanil (cyrponil), dimoxystrobin (dimoxystron), ziram (ziram), silthiofam (silthiofam), streptomycin (streptomycin)n), spiroxamine (spiroxamine), sedaxane (sedaxane), zoxamine (zoxamide), dazomet (dazomet), tiadinil (tiadinil), thiabendazole (thiabendazole), thiram (thiram), thiophanate (thiophanate), thiophanate-methyl, thifluzamide (thifluzamide), tetrachloronitrobenzene (tecnazene), phyllophthalein (tecloftalam), tetraconazole (tetraconazole), debacarb (debacarb), tebuconazole (tebuconazole), tebufquin (terbufine), dodine (dodine), dodemorph (dodemorph), triadimenol (triafol), triadimefon (triadimefon), triazoxide (trifloxystrobine (trifloxystrobin), trifloxystrobin (trifloxystrobin), trifloxystrobin (trifloxystrobin), trifloxystrobin (trifloxystrobin), trifloxystrobin (trifloxystrobin), trifloxystrobin (trifloxystrobin), trifloxystrobin (trifloxystrobin), trifloxystrobin (trifloxystrobin), trifloxystrobin (b), trifloxystrobin (trifloxystrobin), trifloxystrobin (trifl, Tolprarb, sodium (nabam), natamycin (natamycin), naftifine (naftifine), nitrapyrin (nitropyrin), phthalthrin (nitroisopyral), nuarimol (nuarimol), copper nonylphenol sulfonate (copper nonylphenol sulfonate), Bacillus subtilis (strain: T713), validamycin (validamycin), valifenamate (valifenamate), Picarbuzazox, bixafen (bixafen), azoxystrobin (picoxystrobin), pyraflufen (pydiflumetofen), bitertanol (bitonanol), binapacryl (biphenacaproyl), biphenyl (biphenyl), pixilan (peridin), flutriafol (naproxen), naphalonil (naproxen), naproxen (naftifine), naftifine (naproxen), naproxen (naftifine), and Bacillus subtilis (naproxen),
Figure BDA0003617497470000101
Myclofen (hymexazol), pyraoxystrobin (pyraoxystrobin), pyraclostrobin (pyraclotrobin), pyraziflumumid (pyrazofos), pyraclostrobin (pyrazophos), Pyriofenone, pyriftalid (pyrametofenacin), Pyriofenone, pyriftalid
Figure BDA0003617497470000102
Oxazole (pyribenzole), pyribenzoxim (pyrifenox), pyributicarb (pyributicarb), pyrimethanil (pyrimethanil), pyroquilon (pyroquilon), vinclozolin (vinclozolin), ferbam(ferbam)、
Figure BDA0003617497470000103
Famoxadone (fenadone), bismerthiazol (phenazine oxide), fenamidone (fenamidone), fenamipramide (fenaminstrobin), fenamipraminol (fenarimol), fenoxanil (fenoxanil), pyrimethanil (fenpropinol), ferimzone (ferrizome), fenpiclonil (fenpiclonil), fenpicloxamide (fenpyrazamine), fenbuconazole (fenbuconazole), difuramide (fenfurpyram), fenpropidin (fenpropidin), fenpropimorph (fenpropimorph), fenhexamid (fenhexamide), folpet (folpet), tetrachlorophthalide (phthalide), bupirimate (bupirimate), cornuconazole (furazone), blasticidin (bleomycin-S), furazamide (furazamide), flufenapyr (flufenapyr), flufenapyr (fenpyrazone), flufenapyr (flufenapyr), flufenapyr (fenpyrazone (flufenapyr), fluquinconazole (fenpyrazone (flufen), fludioxonil (flufen), flufenapyr (fenpyrazone), flufen (flufen), flufenapyr (fenpyrazone (flufen), flufen (flufen), flufen (flufen) and flufen (flufen) including flufen (flufen), flufen (flufen) and flufen (flufen) salts of flufen), flufen (flufen) salts of flufen (flufen-containing, Flusilazole (flusilazole), flusulfamide (fluuslfamide), fluthiabendazole (fluthianil), flutolanil (flutolanil), flutriafol (flutriafol), fluxapyroxate (flufenoxystrobin), flutolanil (fluetover), flumorph (flumorph), propoxymidine (proquinazid), prochloraz (prochloraz), procymidone (procymidone), thiophanate (procycarb), prothioconazole (prothioconazole), bronopol (bronopol), propamocarb hydrochloride (pamocarb-hydrochloride), propiconazole (propiconazole), propineb (propineb), probenazole (prothioconazole), furazolidone (bronazolidone), fizoquinone (hexitol), flufenoxasol (fluxasol), fenpyraflufenoxate (flufenpyrazox), fenpyrazofenoxate (fenpyrazofenoxate), fenpyrazofenoxapril (fenpyrazofenoxate (fenpyrazone), fenpyrazone (fenpyrazone-benzoate (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone-bencarb-benazolone), fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyrazone (fenpyrazone), fenpyra, Nicotinamide (boscalind), fosetyl (aluminium, calcium, sodium), polyoxin (polyoxin), dysenterin (fosetyl), and fosfomycinZinc (polycarbomate), bordeaux mixture (bordeaxmix), mancozeb (mancozeb), mandipropamid (mandipropamid), Mandestrobin (maneb), maneb (maneb), myclobutanil (myclobutanil), motor oil (mineral oil), milbemycin (milomycin), sulfocarb (methocarbam), metam (metam), metalaxyl (metalaxyl), mefenoxam (metalaxyl-M), metiram (metconazole), metominostrobin (metominostrobin), metrafoxanil (metominostrobin), metominostrobin (metosulosin), mepanipyrim (mepanipyrim), fluroxypyr (metoclopramide), metrafenone (metominostrobin), mepanipyrim (mepanipyrim), fluroxypyr (mepanipyrim), dinate (mepanipyrim), potassium hydroxide (potassium hydroxide), potassium hydroxide (phosphate (potassium hydroxide), potassium hydroxide (potassium hydroxide), potassium hydroxide (potassium hydroxide), potassium hydroxide (potassium hydroxide), potassium hydroxide (potassium hydroxide), potassium hydroxide (potassium hydroxide), potassium hydroxide (potassium hydroxide, potassium sulfate, potassium hydroxide, potassium sulfate, potassium, Copper sulfate (copper sulfate), 3, 4-dichloroisothiazol-5-yl methyl 4- (tert-butyl) benzoate (chemical name, CAS registry number: 1231214-23-5), BAF-045 (code number), BAG-010 (code number), UK-2A (code number), dodecyl benzene sulfonic acid bis (ethylenediamine copper complex salt [ II ]](DBEDC), MIF-1002 (code number), triphenyltin acetate (TPTA), triphenyltin chloride (TPTC), triphenyltin hydroxide (TPTH), nonpathogenic Erwinia carotovora (Erwinia carotovora).
[ herbicidal active ingredients ]
Ioxynil (ioxynil), aclonifen (aclonifen), acrolein (acrolein), azafenidin (azafenidin), acifluorfen (including salts with sodium and the like), azimsulfuron (azimsulfuron), asulam (asulam), acetochlor (acetochlor), atrazine (atrazine), anilofos (anilofos), amicarbazone (amicarbazazone), amidosulfuron (amiosulfuron), imazapyr (amitrole), aminocyclopyrachlor (aminocyclopyrachlor), aminopyralid (aminopyralid), amicarbazone (amifost-methyl), ametryn (amiyntr), alachlor (alchlor), sethoxydim (alloxydim), isoxydim (isoxydim), isoxydim (amicarbazone), amicarbazone (amicarbazone-methyl), ametryl (amicarbazone), alachlor (alchlor), fenoxydim (alloxydim (isoxydim), isoxydim (isoxydim), and cloxydim (amicarbazone) in
Figure BDA0003617497470000121
Long (isour)on), iso
Figure BDA0003617497470000122
Clomazone (isoxacachlortole), isoflurane
Figure BDA0003617497470000123
Carfentrazone-ethyl (isoxaflutole), isoxaflutole
Figure BDA0003617497470000131
Amidofen (isoxaben), isoproturon (isoproturon), mefenacet (imazapyr), imazaquin (imazapic) (including salts with amines and the like), imazapyr (imazapyr) (including salts with isopropylamine and the like), imazamethabenz (imazamethabenz-methyl), imazamox (imazamox), imazethapyr (imazapyr), imazethapyr (imazethapyr), imazosulfuron (imazosulfuron), indoxazole (indofluam), indoxacin (indoflun), glycyrrhiza (eglinazine-ethyl), penoxsulam (proescarb), ethametsulfuron (ethametsulfuron-methyl), ethalfluralin (ethosulfuron-methyl), ethalfluralin (ethofluran), thifensulfuron (thiuron), ethoxysulfuron (ethoxysulfuron-ethyl), ethoxysulfuron-ethyl ester (ethoxysulfuron), ethoxysulfuron (ethoxysulfuron-ethyl ester (ethoxysulfuron), ethoxysulfuron-ethyl ester (ethoxysulfuron-ethyl, ethoxysulfuron-ethyl ester (ethoxysulfuron), ethoxybensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulben (methyl), bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensul-ethyl), bensulbensulbensulbensulbensulbensulbensulbensulbensul-ethyl), bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensul, bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulben, bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensul, bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulben, bensulbensulbensulbensulben, bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulben, bensulbensulbensulbensulbensulbensulbensulbensulben, bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulben,
Figure BDA0003617497470000132
Clomazone (oxadizon), propyne
Figure BDA0003617497470000133
(oxadiargyl) and,
Figure BDA0003617497470000134
Metribuzin (oxaziclomefone), sulfometuron (oxasulfuron), oxyfluorfen (oxyfluorfen), oryzalin (oryzalin), orthosulfamuron (orthosulfamuron), prosulfocarb (orbetarb), oleic acid (oleic acid), cafenstrole (cafenstrole), carfentrazone-ethyl (carfentrazone-ethyl), tetramine (karbutilate), acetochlor (carbetaxamide), quizalofop-ethyl (quizalofop-P-ethyl), quizalofop-P-tefuryl (quizalop-P-tefuryl), quinoxalin (quinoxallop-P-tefuryl) (quinoxalin (quinoxallop-P-tefuryl)ine), quinclorac, cumylquinoline (quinmerac), cumyluron (cumyluron), diclofop (clocynfos), glyphosate (including salts with sodium, potassium, ammonium, amine, propylamine, isopropylamine, dimethylamine or trimethione (trimethysium), glufosinate (including salts with amine or sodium), glufosinate-P-sodium, clethodim (clinethodim), clodinafop-propargyl, clopyralid (clopyralid), isoproxylid (clopyralid), cloquine (trimethacryl), diclofop (trimethoprim), diclofop (trimethacryl), diclofop (trimethoprim), and mixtures thereof
Figure BDA0003617497470000135
Bendiozone (clomazone), metoxyfen (clomethoxam), clomeprop (clomeprop), cloransulam-methyl, chlorambucil (chlor-methyl), chlorambucil (chlorambucil), chlorambucil (chloridazon), chlorimuron-ethyl, chlorsulfuron (chlorimuron-ethyl), chlorimuron-ethyl, chlorimuron-methyl, chlorimuron-dimethyl, chlorimuron-thiamide (chlorimuron-dimethyl), chlorimuron-methyl, chloroanilide (chlorimuron), chlorimuron-methyl, chlorimuron-ethyl, chlortoluon-ethyl, Ketobon-ethyl (including sodium, calcium, ammonia, etc.), chlorambucil (chlorambucil-ethyl), chlorambucil-ethyl (chlorambucil-ethyl), chlorambucil (chlorimuron-ethyl), chlorambucil (chlorambucil-ethyl), chlorambucil (ethyl), chlorambucil-ethyl (sodium), chlorambucil-ethyl (sodium), chlorambucil (sodium, chlorambucil (including sodium, chlorambucil (sodium), chlorambucil (sodium, chlorambucil, sodium (sodium), chlorambucil (sodium), chlorambucil (sodium), chlorambucil (or (sodium), chlorambucil (sodium (or (sodium), chlorambucil (or (salt (sodium (salt (or (salt of chlorambucil), chlorambucil (or (salt (or sodium), chlorambucil (salt of chlorambucil), chlorambucil (or (salt (or (salt), chlorambucil (or (salt), chlorambucil (or (salt), chlorambucil (salt (or (salt (including sodium), chlorambucil (salt (or (salt), chlorambucil (or (salt (or (including chlorambucil), chlorambucil (salt (or (salt (or chlorambucil), chlorambucil (salt), chlorambucil (or (salt), chlorambucil (or (salt, Cyclosulfamuron (cyclosulfamuron), cyclopyromate (cyclopyromate), dichlobenil (dichlobenil), diclofop-P-methyl (diclofop-P-methyl), diclofop-P (diclofop-methyl), 2, 4-dichlorprop (dichlorprop), 2, 4-dichlorprop-P (dichlorprop-P), diquat (diquat), dithiopyr (dithiopyr), siduron (siduron), benfluralin (dinitramine), indolofen-ethyl (cinidon-ethyl), cinosulfuron (cinosulfuron), dinotefol (dinoseb), tylphenol (dinotefuran), dinterbinam (dinetryn-butyl), diphenoyl (diphenoxim), fenpyrozone (diflufenzopyr), pyrazoyl (pyrazofen), metaflumetz (pyraflufen), metaflumetz (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamid (dimethenamid), dimethenamidethynamid), dimethenamid-P, simetryn, dimeperate, bensultap, and optionally, a,
Figure BDA0003617497470000141
Thifenuron (dimefuron), cinmethylin (cinmethylin), swep (swep), sulcotrione (sulcotrione), sulfentrazone (sulfentrazone), sulfothion (sulfosate), sulfosulfuron (sulfosulfosulfuron), sulfometuron (sulfometuron-methyl), sethoxydim (sethoxydim), terfenadine (terbacil), meturon (daimururon), Thaxtomin a, dalapon (dalapon), thiazopyr (thiazopyr), Tiafenacil (thiencarbazone) (including sodium salt, methyl ester, etc.), thiobencarb (carbazone), thiobencarb (thiobencarb), thifenpyrone (thifensulfuron-methyl), thifenpyrone (sulfocarb), thifenpyrone (thifenpyrone), thifenpyrone (thifenteuron), thifenpyrone (thifenpyrone), thifenpyrone (thifluzone), thifluzone (tetramine), thifluzone (tetramethone), thifluzone (tetramethofen), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone ), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone (thifluzone), thifluzone, Triasulfuron (triasulfuron), triafamone (triafamone), triallate (triaallate), metribuzin (triazine), triclopyr (triclopyr), butoxyethyl triclopyr (triclopyr), triflumuron (triflumuron-butyl), trifluralin (triflumuron-sodium), tribenuron (tribenuron-methyl), tolpyrazosulfuron (triflumuron-methyl), tolpyrazamide (napthal) including salts with sodium and the like, naphazoline (naproxamide), naproxen (naproxamide), diuron-M (naproxamide-M), nicosulfuron (nicosulfuron), fensulfuron (fensulfuron-methyl), pyriflufen (butyl), pyriflufen (pyraflufen-ethyl), pyriflufen (pyraflufen-methyl), pyriflufen (pyraflufen-M (P-ethyl), pyriflufen (pyraflufen-ethyl), pyributron (pyraflufen-ethyl), pyributron (pyraflufen-methyl), pyributron (pyrazone-M (pyrazone-methyl), pyrim (pyrazone (pyraflufen-methyl), pyrim (pyraflufen-methyl), pyributron (pyrazone-methyl), pyributron (pyrazone-ethyl (pyrazone-methyl), pyributron (pyrazone-methyl), pyrim (pyrazone-ethyl (pyrazone-methyl), pyributron (pyrazone-ethyl (pyrazone-methyl), pyribenazol-ethyl), pyribenazolone (pyrazone-ethyl (pyrazone-methyl), pyribenazolone (pyrazone-ethyl), pyribenazolone (pyrazone-methyl), pyribenazolin (pyrazone-methyl), pyribenazolone (pyrazone-ethyl), pyribenazolone (pyrazone-methyl), pyribenazolone (pyrazone-ethyl), pyriben-ethyl (pyrazone-ethyl), pyribenazolone (pyrazone-ethyl), pyribenazolone (pyrazone-ethyl), pyribenazolone (pyribenone (pyrazone-ethyl), pyribenone (pyribenazolone (pyribenone (pyrazone-ethyl), pyribenone (pyribenazolone), pyribenazolone (pyribenone), pyribenone (pyribenone), pyribenazolone (pyribenone), pyribenone (pyribenazolone (pyribenone (pyribenazolone), pyribenone (pyribenone), pyribenazolone (pyribenone), pyribenone (pyribenone), pyri, Nitrosulfonamide (halosafen), halosulfuron-methyl (halosulfuron-methyl), picloram (picloram), and pyraflufen-ethylAmine (picolinafen), fluroxypyr (bicyclopyrone), bispyribac-sodium (bispyribac-sodium), pinoxaden (pinoxaden), bifenox (bifenox), piperophos (piperaphos), pyraclonil (pyraclonil), pyrasulfozole (pyrasulfotole), pyraclonil (pyrazoxyfen), pyrazosulfuron-ethyl (pyrazosulfuron-ethyl), pyrazoxol (pyrazolylate), bialaphos (bilifos), pyriflufen-ethyl, pyridaben (pyribenzopyrifos), pyrithiobac-methyl (pyribenzopyribenzoxim), pyrithion (pyribenzoxim-ethyl), pyrithiobac-methyl (pyrithiobac-sodium), pyridaben (pyrithion-thion), pyrithiobac-methyl (pyrithion-thiobac (pyrithiobac-methyl), pyrithion (pyrithiobac-methyl), pyrithiobac-methyl (pyrithiobac-sodium), pyrithiobac-methyl (pyrithion-methyl), pyrithiobac-methyl (pyrithion-sodium), pyrithiobac (pyributron-methyl ether (pyrithion-methyl), pyributron (pyrithion-methyl ether), pyributron (pyributron-sodium), pyributron (pyributron-methyl-sodium), pyributron (pyributron-methyl) and pyributron (pyributron), pyributron-methyl (pyributron), pyributron (pyributron-methyl-ethyl) ether (pyributron), pyributron-methyl-pyributron (pyributron), pyributron-pyributron (pyributron-methyl-pyributron), pyributron (pyributron), pyributron-methyl-pyributron (pyributron-methyl ether (pyributron-methyl) and pyributron (pyributron-methyl) as well as-ethyl, pyributron (pyributron, pyributron (pyributron, pyriben-pyributron, pyributron-pyributron, pyributron-pyributron, pyribut
Figure BDA0003617497470000161
Fenhexasulfone (fenoxasulfolane),
Figure BDA0003617497470000162
Fenoxaprop (including methyl ester, ethyl ester and isopropyl ester), and essence
Figure BDA0003617497470000163
fenoxaprop-P (including methyl, ethyl, isopropyl), Fenquinotrione, fenoxaprop-ethyl, fenpyrazoxam (fenthiapro-ethyl), fentrazamide (fentrazamide), phenmedipham (phenmedipham), butachlor (butachlor), butafenacil (butafenacil), butafosetyl (butamifos), butafenacil (butralin), butafenacet (butralin), flazasulfuron (flazasulfuron), flazasulfuron (flumoprop) (including methyl, ethyl, isopropyl), fludar (flufenoxaprop-M) (including methyl, ethyl, isopropyl), flufensulfuron-ethyl (flufenoxaprop-P), flufenoxaprop-ethyl (flufenuron-P), flufenfluridone (butyl-ethyl), flufenfluridone (fluridone-ethyl), flufensulfuron-ethyl), flufenfluridone (fluorofenoxaprop-ethyl), flufenfluridone (fluridone-butyl-ethyl), flufenfluridone (fluridone (butyl-ethyl), fluridone (butyl-ethyl, isopropyl), flufenoxaprop-P (butyl-P), fluridone (butyl-P), flufenoxaprop-P (butyl-P), benfluridone (butyl-ethyl, benfluridone) (including benfluridone), benfluridone (butyl-ethyl), benfluridone) (including benfluridone (butyl-ethyl, benfluridone), benflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenfluridone) (including benflurbenflurbenflurbenflurbenflurbenfluridone), benflurbenfluridone) (including benflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbensul-ethyl), benflurbenflurbenflurbenflurbenflurbenflurbenflurben-P), benflurben-P), benflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurben-P), benflurbenflurbenflurben-ethyl), benflurbensul-ethyl), benflurbenflurbenflurbenflurbenflurbenflurbenflurbensul-ethyl, bensul-P), bensul-ethyl, benflurbenflurbenflurbenflurbensul-ethyl, bensul-P), benflurben-P), bensul-P-ethyl, bensul-ethyl, benflurbenflurbensul-ethyl, bensul-ethyl, benflurbensul-ethyl, benflurbenflurbenflurbenflurbensul-ethyl, benflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbenflurbensul-ethyl, benflurbensul-ethyl, benflurbenflurbenflurbenflurbensul-ethyl, benflurbenflurbensul-ethyl, bensul-ethyl, benflurbenflurbenflurbenflurbenflurbenflurbenflurbensul-ethyl, bensul-ethyl, benflurben-ethyl, bensul-ethyl, benflurbensul-ethyl, bensul-ethyl, benflurben, Fluthiamide, flupyrsulfuron-methylsulfuron-methyl-sodium, flufenacet (flufenacet), flupyridaphenthrin (flufenpyr-ethyl), tetrafluoropropionic acid (flupropanoate), flufenpyrad (flupropxame), flumioxazin (fludioxozin), flumethac acid (fluiclorac-pentyl), flumetsulam (fluetsulam), flazazone (fluridone), flurtamone (flutamone), fluroxypyr (fluroxypyr), flutolcloflozin (fludioxonil), pretilac (prophalator), propamocarb (propamocarb-sodium), propamocarb (propyzamide), propyzamide (propyzamide), propyzamide (propyzamide), propyzamide (proplate (propyzamide), propyzamide (proplate (propyzamide), propyzamide (proplate (propyzamide), propyzamide (proplate (propyzamide), propyzamide (propathrin (propyzamide), propyzamide (propathrin), propathrin (propathrin), propathrin (propathrin), propathrin (propathrin), propathrin (propathrin), propathrin (propathrin), propathrin (propathrin), propathrin (propathrin), propathrin (propathrin, Prometon (prometon), bromoxynil (bromoxynil) (including esters with butyric acid, caprylic acid, heptanoic acid, or the like), bromophenol oxime (bromofenoxim), bromobutyric acid (bromobutyride), florasulam (florasulam), Florpyrauxifen, hexazinone (hexazinone), pethoxamid (pethoxamid), benazolin (benazolin), penoxsulam (penoxsulam), pyraflufen (heptaloxylognan), beflubutamid (beflubutamid), dichlorphenate (petalate), pelargonic acid (pelarnic acid), bentazone (bencarbazone), pendimethalin (pendimethalin), bensulfuron (bensulfuron), bensulam (pendifenon), bensulfuron (bensulfuron), bentazone (bensulam), penfensulfuron (bensulfuron), bensulfuron (bensulone), pensulam (pensulam), pensulam (benzofenapyr (pensulone), pensulam (benzofenapyr (bensulone), pensulone (bensulone), pensulone (bensulone), pensulam (bensulam), pensulam (bensulam), pensulam (bensulam), pensulam (bensulam), pensulam (bensulam), pensulam (bensulam), pensulam (bensulam), bensulam (bensulam), bensulam (bensulam), bensulam (bensulam), bensulam (bensulam), bensulam (bensulam), bensulam (ben
Figure BDA0003617497470000171
Clomazone, benfluralin, benfuresate, fomesamine, fomesafen, fomesasulfuron, 2-methyl-4-chloropropionic acid (mecoprop), including salts with sodium, potassium, isopropylamine, triethanolamine, dimethylamine, etc., 2-methyl-4-chloropropionic acid (mecoprop-P-potassium), mesosulfuron-methyl, mesotrioneone), metazachlor (metazachlor), metazosulfuron (metazosulfuron), methabenzthiazuron (methabenzthiazuron), metamitron (metamitron),
Figure BDA0003617497470000172
Metosulam (metamifop), DSMA (disodium Mersonic acid), Methiozolin, metsulfuron (methydymron), metoxuron (metoxuron), metosulam (metosulam), metsulfuron (metsuluron-methyl), bromogluron (metocrouron), pyrosulfuron (metobenuron), metolachlor (metosulzin), mefenacet (mebendazole), mefenacet (mefenacet), rimuron (monsuluron) (including methyl, ethyl, isopropyl), chlorsulfuron (monolinuron), dichlofop (molinate), iodosulfuron (iodosulfuron), iodosulfuron-methyl-sodium (iodosulfuron-methyl-sodiuron), Iofensulfuron, iofenuron-sodium, flufenoxuron (lactofen), lactosulfuron (Lauriron), 2-methyl-thion (2-thiosulfuron), 2-methyl-thiosulfuron (2-methyl-thiosulfuron), 2-methyl-thiosulfuron (2, 5, 2-trichlorosulfuron, 2-methyl-thiosulfuron (metosulron, 5, 2-methyl-thiosulfuron, 2,5, 2-thiosulfuron, 2, 2-methyl-thiosulfuron, 2,2,5, 2-thiosulfuron, 2,2,2, and 5, 4,5-T), 2, 4-dichlorophenoxyacetic acid (2,4-D) (including salts with amines, diethylamine, triethanolamine, isopropylamine, sodium or lithium, etc.), ACN (2-amino-3-chloro-1, 4-naphthoquinone), 2 methyl 4 chloro (MCPA), 2 methyl 4 chlorobutyric acid (MCPB) (including sodium salts, ethyl esters, etc.), 2, 4-D-butyric acid (2,4-DB), Dinitrophenol (DNOC) (including salts with amines or sodium, etc.), AE-F-150944 (code), HW-02 (code), IR-6396 (code), 2 methyl 4 chlorothioethyl ester (MCPA-thioethyl), SYP-298 (code), SYP-300 (code), molinate (EPTC), S-metolachlor (S).
[ plant growth regulating active ingredient ]
1-methylcyclopropene (1-methylcyclopropene), 1-naphthylacetamide (1-naphthylacetamide), 2, 6-diisopropylnaphthalene (2, 6-diisopropypyl naphthalene), 4-chlorophenoxyacetic acid (4-CPA), benzylaminopurine (benzylaminopurine), cyclopropylpyrimidol (aminocyclopropanol), avidinone (aviglcycine), carvone (carvone), chlormequat chloride (chlormequat), cloproprotic acid (cyclopropp), cloxyfonc acid (cloxyfonac), cloxyfonic acid potassium salt (cloxyfonac-potatassium), cyclamic acid (cyclanilide), cytokinin (cyclinins),Butyryl hydrazine (daminozide), furoic acid (dikegulac), thionine (dimethipin), ethephon (ethephon), propionyl brassinolide (epocholone), indyl ester (ethychozate), flumetralin (flumetralin), fluorebutyl ester (flurenol), flurprimidol (flurprimidol), forchlorfenuron (forchlorfenuron), gibberellin (gibberellins), trinexamide (inamide), indoleacetic acid (indole acetic acid), indolebutyric acid (indole butyric acid), maleic hydrazide (maleic hydrazide), fluorosulfonyl oxamide (mefluidum), mepiquide (mepiquide), piperonyl-p-methyl
Figure BDA0003617497470000181
(mepiquat chloride), n-decanol (n-decanol), paclobutrazol (paclobutrazol), prohexadione-calcium, jasmone (prohydrojasmon), azoxystrobin (sintofen), thidiazuron (thiazuron), triacontanol (triacontanol), trinexapac-ethyl (trinexapac-ethyl), uniconazole (uniconazole-P), 4-oxo-4- (2-phenylethyl) aminobutyric acid (chemical name, CAS accession No. 1083-55-2), calcium peroxide.
Among these pesticidal active ingredients, those having a solubility in water of 100ppm or less are preferable, and those having a solubility in water of 0.05 to 95ppm are more preferable. The solubility in water is a value measured in distilled water at 20 ℃. The agricultural chemical active ingredient having a solubility in water of 100ppm or less is not limited to the following examples, and examples thereof include: pyrazocarb (pyribencarb) (63ppm), benthiavalicarb-isopyl (13.1ppm), mepanipyrim (mepanipyrim) (3.1ppm), dichlobemine (36.0ppm), chlorantraniliprole (chlorantraniliprole) (1.0ppm), fenpyrad (tetramiluron) (1.2ppm), cyantraniliprole (cyantraniliprole) (14.2ppm), isothiavalicarb (isothianil) (0.5ppm), pyrisoxazone (ferimzone) (20.8ppm), phthalide (phthalide) (46.2ppm), ethiprolonitrile (ethiprole) (9.2ppm), spinetoram (spinetoram) (31.9ppm), oxazofuryl (15.6ppm), flufenpyrad (flufenpyrazam) (10.9ppm), fenpyrazosulfuron-ethyl) (10.5ppm), thifensulfuron-ethyl (fensulfuron-ethyl) (10.10 ppm), thifensulfuron-ethyl-methyl (5.5 ppm), thifensulfuron-ethyl-methyl (thifenpyrad) (10.9ppm), thifensulfuron-ethyl-methyl) (10.9ppm), thifenpyrad (fensulfuron-ethyl thiuron) (10.5ppm), thiuron (5 ppm), thifenpyr-methyl) (10.6 ppm), thifenpyr-methyl (thifenpyr-ethyl thifenpyr-methyl) (10.5-ethyl-methyl) (10, thifenpyr-ethyl thifenpyr) (10, thifenpyr-methyl) and thifenpyr-methyl) respectively,
Figure BDA0003617497470000191
Clomazone (0.57ppm), propyne
Figure BDA0003617497470000192
Clomazone (oxadiargyl) (0.37ppm), chlorimuron-ethyl (8.6ppm), cyclosulfamuron (0.34ppm), imazasulfuron (0.79ppm), triafamone (41ppm), halosulfuron-methyl (10.2ppm), pyraclonil (50.1ppm), pyrazosulfuron-ethyl (9.8ppm), pyriftalid (1.8ppm), pyribenzoxim (3.5ppm), pyrimethanil (87ppm), pyrimethanil (pyrimethanil-methyl) (E-type 9.3ppm), pyrazosulfuron-ethyl (3.5ppm), pyrimethanil (87ppm), pyrimethanil (pyrimethanil-methyl) (E-type 9.3ppm), pyrimethanil (pyrimethanil-sulfone (3.5ppm), bensulfuron-methyl (3 ppm), bensulfuron-methyl (8 ppm)
Figure BDA0003617497470000193
Carfentrazone (fenoxasulfone) (0.17ppm), Fenquinotrione (17ppm), butachlor (butachlor) (16ppm), propanil (propanil) (95ppm), propyrisulfuron (propyrisulfuron) (0.98ppm), fluthiamide (fluthiamide-methyl) (0.85ppm), pretilachlor (74ppm), penoxsulam (penoxsulam) (4.9ppm), bensulfuron-methyl (bensulfuron-methyl) (6.7ppm), benzofenap (benzofenap) (0.12ppm), benzobicylon (benzobicylon) (0.052ppm), cyclopentadienone (bensulfuron-methyl) (6.7ppm)
Figure BDA0003617497470000201
-clomazone (0.22ppm), pendimethalin (0.26ppm),
Figure BDA0003617497470000202
Metolachlor (metamifop) (0.69ppm), mefenacet (mefenacet) (5.2 ppm).
The above-mentioned pesticidal active ingredient may be used as it is as long as the volume median particle diameter is within the above-mentioned range, and if necessary, it may be controlled to be within the above-mentioned range by a pulverizing means such as wet pulverization or dry pulverization.
The water-soluble polymer used in the composition of the present invention is not particularly limited, and examples thereof include: polyvinyl alcohol, polyacrylic acid polymers, polyacrylamide, polyethylene oxide, polyvinylpyrrolidone, and the like. These water-soluble polymers may be used in 1 kind or in combination of 2 or more kinds. Among these water-soluble polymers, polyvinylpyrrolidone is preferable because of its high elution property of the agricultural chemical active ingredient.
It is known that this polyvinylpyrrolidone exhibits different viscosity in an aqueous solution depending on the degree of polymerization of a vinylpyrrolidone monomer constituting the polyvinylpyrrolidone, and an index thereof is a K value represented by the following formula (I).
[ number 1]
Figure BDA0003617497470000203
(where c represents the number of grams of polyvinylpyrrolidone in 100mL of the solution,. eta.relIndicating the relative viscosity of the solution with respect to water. )
The K value of the polyvinylpyrrolidone used in the composition of the present invention is not particularly limited, but is usually 10 to 110, preferably 20 to 100. The K value is a value obtained by measuring the viscosity of a 1 mass% aqueous solution of polyvinylpyrrolidone at 25 ℃ with a capillary viscometer.
The amount of the pesticidal active ingredient and the water-soluble polymer to be blended in the composition of the present invention is not particularly limited, and for example, is 0.1 to 50.0 parts by mass, preferably 0.5 to 30.0 parts by mass, and 0.1 to 20.0 parts by mass, preferably 0.1 to 10.0 parts by mass, based on 100 parts by mass of the composition of the present invention. The ratio of the pesticidal active ingredient to the water-soluble polymer in the composition of the present invention is not particularly limited, and for example, the mass ratio of the pesticidal active ingredient to the water-soluble polymer is 1: 0.05 to 100.0, preferably 0.1 to 20.0.
The composition of the present invention may contain, in addition to the above-mentioned crystal grains of the pesticidal active ingredient having a volume median particle diameter of less than 1 μm and the water-soluble polymer, the following: solid carriers/excipients such as bentonite, clay, kaolin, sericite, talc, acid clay, pumice, zeolite, vermiculite, perlite, calcium carbonate, silica sand, etc.; alkyl sulfatesSurfactants such as salts, arylsulfonates, polyoxyethylene glycol ethers, polyol esters, dialkyl sulfosuccinates, polycarboxylic acids, polyoxyethylene nonylphenyl ether, and sodium lignosulfonate; binders such as starch, alginic acid, glycerin, polyvinylpyrrolidone, polyurethane, polyethylene glycol, polypropylene glycol, polybutene, polyvinyl alcohol, gum arabic, liquid paraffin, ethyl cellulose, and polyvinyl acetate; lubricants such as calcium stearate, talc, and silica; colorants such as dyes and pigments; benoxacor (benoxacor) and jicao
Figure BDA0003617497470000211
Oxazole (furilazole), dichlormid (dichlormid), Dicyclonone, N1, N2-diallyl-N2-dichloroacetyl glycinamide (DKA-24), jieda (AD-67), 2-dichloro-N- (1, 3-bis-dichloro-glycine-amide (DKA-67)
Figure BDA0003617497470000212
Alk-2-ylmethyl) -N- (2-propenyl) acetamide (PPG-1292), 3-dichloroacetyl-2, 2, 5-trimethyl-1, 3-
Figure BDA0003617497470000213
Oxazolidine (R-29148), cloquintocet-mexyl, Naphthalic Anhydride (1,8-Naphthalic Anhydride), Mefenpyr-diethyl, fenchlorazole-O-ethyl, fenchlorazole (fenchlorazole-O-ethyl), fenclorim (fenclorim), benazolin (MG-191), fenchloranil (cyclotrinil), fenchlorazole (flurazole), fluxofenam (fluxofenim), bisphenylene
Figure BDA0003617497470000214
Azoic acid (isoxadifen), bisbenzene
Figure BDA0003617497470000215
Ethyl Azolorate (isoxadifen-ethyl), MON4660 (code), oxabetrinil, cyprosulfamide, lower alkyl substituted benzoic acid, TI-35 (code), or N- (2-methoxybenzoyl) -4- [ (methylaminocarbonyl) amino]Benzenesulfonamide (chemical name, CAS accession number: 129531-12-0) and the likeA lightening agent. The amounts and proportions of these components in the composition of the present invention can be appropriately determined by those skilled in the art.
Preferred embodiments of the composition of the present invention include the following embodiments.
The pesticide active component (volume median particle diameter is 0.01-less than 1.0 mu m): 0.1 to 50.0 parts by mass
Water-soluble polymer: 0.1 to 20.0 parts by mass
Solid carrier: 0 to 30.0 parts by mass
Surfactant (b): 0.1 to 30.0 parts by mass
Excipient: 0.1 to 99.6 parts by mass
Adhesive: 0.1 to 10.0 parts by mass
Lubricant: 0 to 3.0 parts by mass
Colorant: 0 to 5.0 parts by mass
Phytotoxicity reducing agent: 0 to 40.0 parts by mass
The composition of the present invention can be produced by a conventional method, except that it contains the above-mentioned components. The composition of the present invention may be in the form of granules, suspensions, powders, solutions and the like, and preferably suspensions and powders.
Preferred production methods of the composition of the present invention include, for example: a method comprising the following process steps: a step of pulverizing the crystal grains of the agricultural chemical active ingredient to a volume median diameter of less than 1 μm; and a step of mixing the crystal grains of the agricultural chemical active ingredient with the water-soluble polymer before or after the pulverization step (hereinafter, this is referred to as "the method of the present invention").
In the method of the present invention, the step of pulverizing the crystal grains of the agricultural chemical active ingredient to a volume median diameter of less than 1 μm may be carried out by a pulverizing means such as dry pulverization or wet pulverization to fall within the above-mentioned range.
In the method of the present invention, the step of mixing the crystal grains of the agricultural chemical active ingredient with the water-soluble polymer, which is performed before or after the pulverization step, is performed by, for example, mixing by a mixing means such as stirring.
Further, the method of the present invention preferably includes a step of obtaining the liquid pesticide composition in suspension by wet-grinding the grinding step. The wet grinding is not particularly limited, and is carried out by using a solvent such as water added to an attritor, a paint shaker, a sand mill, or the like. This makes it possible to relatively easily make the volume median diameter of crystal grains of the pesticidal active ingredient less than 1 μm, by forming the pesticidal composition into a suspension.
In the method of the present invention, it is preferable that the suspension-type agricultural chemical composition obtained as described above is mixed with a powder containing a solid carrier to obtain a mixture, and the mixture is granulated to obtain a granular agricultural chemical composition. As the solid carrier, the same carrier as described above is used. The powder may further contain the same excipient, surfactant, and the like as described above.
The method and conditions for granulating the above mixture are not particularly limited, and known granulation methods such as extrusion granulation, fluidized bed granulation, and coating granulation can be used, and the conditions are also known.
Further, the granulated agricultural chemical composition may be further subjected to a drying step or the like as needed.
The composition of the present invention thus obtained has improved dissolution properties (dissolution rate) of the pesticidal active ingredient in water. The improvement in the dissolution property (dissolution rate) means, for example, 2 to 6 times as high as when coarse particles of crystals of the pesticidal active ingredient are used and 2 to 3 times as high as when fine particles are used.
Examples
The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples.
In the following examples, the average particle diameter refers to a median particle diameter (volume median particle diameter) of a volume particle size distribution measured by a laser analysis type particle size distribution measuring apparatus. The K value is a value obtained by measuring the viscosity of a 1 mass% aqueous solution of polyvinylpyrrolidone at 25 ℃ with a capillary viscometer. Further, a diffraction pattern of the pesticidal composition was obtained using a powder X-ray diffraction apparatus, and it was confirmed that a peak appeared at a peak position specific to the crystal grain of each pesticidal active ingredient, and the existence of the crystal grain was confirmed. The slurries obtained from the examples all had crystals of the pesticidal active ingredient present therein.
Example 1
20 parts of chlorantraniliprole (chlorantraniliprole), 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 5 parts of polyvinylpyrrolidone (K value of 27.0 to 33.0), 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" (bronopol), and a predetermined amount of water were mixed together to make the total amount to 100 parts. The mixture was wet-pulverized to an average particle diameter of 0.24 μm using zirconia beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Example 2
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 10.5 parts of polyvinylpyrrolidone (K value is 27.0-33.0), 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of CMIT, MIT and bronopol and a predetermined amount of water are mixed together to make the total amount to 100 parts. The mixture was wet-pulverized to an average particle diameter of 0.66 μm using zirconia beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Example 3
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 3.2 parts of polyvinylpyrrolidone (K value is 27.0-33.0), 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of CMIT, MIT and bronopol and a predetermined amount of water are mixed together to make the total amount to 100 parts. The mixture was wet-pulverized to an average particle diameter of 0.67 μm using zirconia beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Example 4
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 5.3 parts of polyvinylpyrrolidone (K value is 27.0-33.0), 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of CMIT, MIT and bronopol and a predetermined amount of water are mixed together to make the total amount to 100 parts. The mixture was wet-pulverized to an average particle diameter of 0.72 μm using zirconia beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed together to make the total amount 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Example 5
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 7.2 parts of polyvinylpyrrolidone (having a K value of 27.0 to 33.0), 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of CMIT, MIT and bronopol, and a predetermined amount of water were mixed together, and the total amount was 100 parts. The mixture was wet-pulverized to an average particle diameter of 0.73 μm using zirconia beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Example 6
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 5.3 parts of polyvinylpyrrolidone (K value is 27.0-33.0), 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of CMIT, MIT and bronopol and a predetermined amount of water are mixed together to make the total amount to 100 parts. The mixture was wet-pulverized to an average particle diameter of 0.60 μm using zirconia beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture, a predetermined amount of water was added and kneaded, and extrusion granulation was performed using a mesh with a pore size of 1.2mm, followed by drying to remove water, to obtain a granular pesticide composition.
Example 7
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed so that the total amount was 95 parts. This mixture was wet-pulverized to an average particle diameter of 0.77 μm using zirconia beads as a pulverization medium, and 5 parts of water was further added to obtain a slurry containing chlorantraniliprole.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 99.8 parts (dry basis). To this mixture, a predetermined amount of water in which 0.2 part of polyvinylpyrrolidone (K value of 27.0 to 33.0) was dissolved was added and kneaded, and extrusion granulation was performed using a sieve having an aperture of 1.2mm, followed by drying to remove water, thereby obtaining a granular agricultural chemical composition.
Example 8
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed so that the total amount was 95 parts. The mixture was wet-pulverized to an average particle diameter of 0.77 μm using glass beads as a pulverization medium, and 5 parts of water was further added to obtain a slurry containing chlorantraniliprole.
3.75 parts of the slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 99.5 parts (dry basis). To this mixture, a predetermined amount of water in which 0.5 part of polyvinylpyrrolidone (K value of 27.0 to 33.0) was dissolved was added and kneaded, and extrusion granulation was performed using a sieve having an aperture of 1.2mm, followed by drying to remove water, thereby obtaining a granular agricultural chemical composition.
Example 9
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed so that the total amount was 95 parts. The mixture was wet-pulverized to an average particle diameter of 0.77 μm using glass beads as a pulverization medium, and 5 parts of water was further added to obtain a slurry containing chlorantraniliprole.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 99 parts (dry basis). To this mixture, a predetermined amount of water in which 1 part of polyvinylpyrrolidone (K value 27.0 to 33.0) is dissolved is added and kneaded, and extrusion granulation is performed using a sieve having an aperture of 1.2mm, followed by drying to remove water, thereby obtaining a granular pesticide composition.
Example 10
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed so that the total amount was 95 parts. The mixture was wet-pulverized to an average particle diameter of 0.77 μm using glass beads as a pulverization medium, and 5 parts of water was further added to obtain a slurry containing chlorantraniliprole.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 98.5 parts (dry basis). To this mixture, a predetermined amount of water in which 1.5 parts of polyvinylpyrrolidone (K value of 27.0 to 33.0) was dissolved was added and kneaded, and extrusion granulation was performed using a sieve having an aperture of 1.2mm, followed by drying to remove water, thereby obtaining a granular agricultural chemical composition.
Example 11
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed so that the total amount was 95 parts. The mixture was wet-pulverized to an average particle diameter of 0.77 μm using glass beads as a pulverization medium, and 5 parts of water was further added to obtain a slurry containing chlorantraniliprole.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 98 parts (dry basis). To this mixture, a predetermined amount of water in which 2 parts of polyvinylpyrrolidone (K value 27.0 to 33.0) was dissolved was added and kneaded, and extrusion granulation was performed using a sieve having an aperture of 1.2mm, followed by drying to remove water, thereby obtaining a granular pesticide composition.
Comparative example 1
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed so that the total amount became 100 parts. The mixture was wet-pulverized to an average particle diameter of 0.24 μm using zirconia beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Comparative example 2
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 5.3 parts of polyvinylpyrrolidone, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed so that the total amount became 100 parts. The mixture was wet-pulverized to an average particle diameter of 2.08 μm using glass beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Comparative example 3
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 5.3 parts of polyvinylpyrrolidone, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed so that the total amount became 100 parts. The mixture was wet-pulverized to an average particle diameter of 1.42 μm using glass beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Comparative example 4
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 5.3 parts of polyvinylpyrrolidone, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed so that the total amount became 100 parts. The mixture was wet-pulverized to an average particle diameter of 1.07 μm using glass beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture, a predetermined amount of water was added and kneaded, and extrusion granulation was performed using a mesh with a pore size of 1.2mm, followed by drying to remove water, to obtain a granular pesticide composition.
Comparative example 5
20 parts of chlorantraniliprole, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol" and a predetermined amount of water were mixed to make the total amount 100 parts. This mixture was wet-pulverized to an average particle diameter of 0.77 μm using zirconia beads as a pulverization medium to obtain a chlorantraniliprole-containing slurry.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Comparative example 6
20 parts of chlorantraniliprole having an average particle size of about 20 μm, which had been subjected to impact pulverization in advance, 5 parts of lignosulfonate, 3 parts of polyoxyethylene alkyl ether sulfate, 0.2 part of dimethylpolysiloxane, 0.2 part of a mixture of "CMIT, MIT and bronopol", and a predetermined amount of water were mixed together to make the total amount to 100 parts, to obtain a slurry containing chlorantraniliprole.
3.75 parts of the above slurry, 2 parts of Dichlobenthiazox, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, 3 parts of calcium carbonate, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Test example 1
100mg of the granular pesticidal compositions of examples 1 to 11 and comparative examples 1 to 6 were put into 700mL of 3-degree hard water, and the concentration of chlorantraniliprole in the water after a predetermined time was measured by high performance liquid chromatography. The measurement results are shown in Table 1.
[ Table 1]
Figure BDA0003617497470000301
The dissolution rate (dissolution concentration) when the average particle size is less than 1 μm and PVP (polyvinylpyrrolidone) is about 7 times or so as to be the maximum when the average particle size is 1 μm or more and PVP is not contained, and about 4 times or so as to be the maximum when the average particle size is less than 1 μm and PVP is not contained, and about 3 times or so as to be the maximum when the average particle size is 1 μm or more and PVP is contained, and the rate of increase in the dissolution rate when the average particle size is less than 1 μm and PVP is contained is the highest.
Example 12
4.47 parts of penoxsulam (pyrimisulfan), 26.78 parts of Fenquinotrione, 3 parts of polyoxyethylene allyl phenyl ether ammonium sulfate salt, 10 parts of propylene glycol, 0.15 part of xanthan gum, 0.2 part of a mixture of "CMIT, MIT and bronopol", 0.02 part of dimethylpolysiloxane, and a prescribed amount of water were mixed so that the total amount became 100 parts. The mixture was wet-pulverized to an average particle size of 0.23 μm using zirconia beads as a pulverization medium to give a slurry containing penoxsulam (pyrimisulfan) and fenquinolonone.
11.21 parts of the slurry, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, and a predetermined amount of clay were mixed so that the total amount was 99 parts (dry basis). To the mixture was added a predetermined amount of water in which 1 part of polyvinylpyrrolidone was dissolved, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular agricultural chemical composition.
Comparative example 7
4.47 parts of penoxsulam (pyrimisulfan), 26.78 parts of Fenquinotrione, 3 parts of polyoxyethylene allyl phenyl ether ammonium sulfate salt, 10 parts of propylene glycol, 0.15 part of xanthan gum, 0.2 part of a mixture of "CMIT, MIT and bronopol", 0.02 part of dimethylpolysiloxane, and a prescribed amount of water were mixed so that the total amount became 100 parts. The mixture was wet-pulverized to an average particle size of 0.23 μm using zirconia beads as a pulverization medium to give a slurry containing penoxsulam (pyrimisulfan) and fenquinolonone.
11.21 parts of the slurry, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture, a predetermined amount of water was added and kneaded, and extrusion granulation was performed using a mesh with a pore size of 1.2mm, followed by drying to remove water, to obtain a granular pesticide composition.
Test example 2
100mg of the granular pesticidal compositions of example 12 and comparative example 7 were put into 700mL of 3-degree hard water, and the concentration of penoxsulam (pyrimisulfan) in water and the concentration of fenquinolonotrione in water after 1 day were measured by high performance liquid chromatography. The measurement results are shown in Table 2.
[ Table 2]
Figure BDA0003617497470000321
Example 12
Both sulfentrazone (pyrimisulfan) and fenquinolone were observed to have enhanced dissolution concentrations with an average particle size of less than 1 μm and with PVP.
Example 13
47.62 parts of pyraflufen-ethyl (pyroxasulfone), 1.97 parts of naphthalenesulfonate formaldehyde condensate, 0.69 part of dialkyl sulfosuccinate, 0.98 part of polyoxyethylene tristyrylphenyl ether, 11.87 parts of propylene glycol, 0.06 part of xanthan gum, 0.03 part of a mixture of "CMIT, MIT and bronopol", 0.24 part of dimethylpolysiloxane, and a predetermined amount of water were mixed so that the total amount became 100 parts. The mixture was wet-pulverized to an average particle diameter of 3 μm using glass beads as a pulverization medium to obtain a primary slurry.
In addition, 4.09 parts of propylene glycol, 0.35 part of xanthan gum, 0.09 part of dimethylpolysiloxane, "0.04 part of a mixture of CMIT, MIT and bronopol", 0.35 part of bentonite and a predetermined amount of water were mixed, and the total amount was made 100 parts to prepare a diluted solution.
76.99 parts of the above-mentioned primary slurry and 23.01 parts of a diluent were mixed, and the mixture was wet-pulverized using zirconia beads as a pulverization medium to an average particle diameter of 0.66 μm to obtain a secondary slurry containing pyroxasulfone.
2.5 parts of the secondary slurry, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, and a predetermined amount of clay were mixed so that the total amount was 99 parts (dry basis). To the mixture was added a predetermined amount of water in which 1 part of polyvinylpyrrolidone was dissolved, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular agricultural chemical composition.
Comparative example 8
47.62 parts of pyraflufen-ethyl (pyroxasulfone), 1.97 parts of naphthalenesulfonate formaldehyde condensate, 0.69 part of dialkyl sulfosuccinate, 0.98 part of polyoxyethylene tristyrylphenyl ether, 11.87 parts of propylene glycol, 0.06 part of xanthan gum, 0.03 part of a mixture of "CMIT, MIT and bronopol", 0.24 part of dimethylpolysiloxane and a predetermined amount of water were mixed together to make the total amount to 100 parts. The mixture was wet-pulverized to an average particle diameter of 3 μm using glass beads as a pulverization medium to obtain a primary slurry.
In addition, 4.09 parts of propylene glycol, 0.35 part of xanthan gum, 0.09 part of dimethylpolysiloxane, 0.04 part of "mixture of CMIT, MIT and bronopol", 0.35 part of bentonite, and a predetermined amount of water were mixed, and the total amount was made 100 parts to prepare a diluted solution.
76.99 parts of the above-mentioned primary slurry and 23.01 parts of a diluent were mixed, and the mixture was wet-pulverized using zirconia beads as a pulverization medium to an average particle diameter of 0.66 μm to obtain a secondary slurry containing pyroxasulfone.
2.5 parts of the secondary slurry, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, and a predetermined amount of clay were mixed so that the total amount was 100 parts (dry basis). To this mixture was added a predetermined amount of water, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular pesticide composition.
Test example 3
The granular agrochemical compositions of example 13 and comparative example 8 were put into 700mL of 3-degree hard water at 100mg, and the concentration of pyriflufen (pyroxasulfone) in the water after 1 day was measured by high performance liquid chromatography. The measurement results are shown in Table 3.
[ Table 3]
Granular pesticide composition Concentration of pyraflufen-ethyl in water [ ppb]
Example 13 68.4
Comparative example 8 58.5
An increase in the dissolution concentration was observed with sulfoxaflor (pyroxasulfone) having an average particle size of less than 1 μm and containing PVP.
Example 14
Benzene sulfonic acid
Figure BDA0003617497470000341
30 parts of carfentrazone-ethyl (fenoxasulfone), 12 parts of naphthalenesulfonate formaldehyde condensate, 1 part of dialkyl sulfosuccinate, 1.4 parts of polyoxyethylene styryl phenyl ether sulfate, 0.4 part of polyoxyethylene alkyl ether, 6.2 parts of propylene glycol, 0.05 part of xanthan gum, 0.1 part of a mixture of "CMIT, MIT and bronopol", 0.02 part of dimethylpolysiloxane and a predetermined amount of water were mixed so that the total amount became 100 parts. Using zirconia beads as a pulverizing medium, mixing the mixtureWet-pulverizing the resultant mixture to an average particle size of 0.16 μm to obtain a powder containing benzenesulfonic acid
Figure BDA0003617497470000342
A slurry of fenxasulfone.
6.67 parts of the secondary slurry, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, and a predetermined amount of clay were mixed so that the total amount was 99 parts (dry basis). To the mixture was added a predetermined amount of water in which 1 part of polyvinylpyrrolidone was dissolved, kneaded, extruded and granulated using a sieve having an aperture of 1.2mm, and then dried to remove water, thereby obtaining a granular agricultural chemical composition.
Comparative example 9
Benzene sulfonic acid
Figure BDA0003617497470000343
30 parts of carfentrazone-ethyl (fenoxasulfone), 12 parts of a naphthalenesulfonate formaldehyde condensate, 1 part of a dialkyl sulfosuccinate, 1.4 parts of polyoxyethylene styrylphenyl ether sulfate, 0.4 part of polyoxyethylene alkyl ether, 6.2 parts of propylene glycol, 0.05 part of xanthan gum, 0.1 part of a mixture of "CMIT, MIT and bronopol", 0.02 part of dimethylpolysiloxane, and a predetermined amount of water were mixed to make the total amount 100 parts. Wet-pulverizing the mixture to an average particle diameter of 0.16 μm using zirconia beads as a pulverizing medium to obtain a mixture containing benzenesulfonic acid
Figure BDA0003617497470000344
A slurry of fenxasulfone.
6.67 parts of the secondary slurry, 0.1 part of polyoxyethylene alkyl ether sulfate, 3 parts of pregelatinized starch, and a predetermined amount of clay were mixed together to make the total amount 100 parts (dry basis). To this mixture, a predetermined amount of water was added and kneaded, and extrusion granulation was performed using a mesh with a pore size of 1.2mm, followed by drying to remove water, to obtain a granular pesticide composition.
Test example 4
The granular pesticidal compositions of example 14 and comparative example 9 were put into 700mL of 3-degree hard water (100 mg), and the content of phenylsulfon in the water after 3 days was measured by high performance liquid chromatography
Figure BDA0003617497470000345
Concentration of pennisetum flaccidum (fenoxasulfone). The measurement results are shown in Table 4.
[ Table 4]
Figure BDA0003617497470000351
Benzene sulfonic acid
Figure BDA0003617497470000352
An increase in the dissolution concentration was observed for carfentrazone-ethyl (fenoxasulfone) having an average particle size of less than 1 μm and containing PVP.
Industrial applicability
The pesticidal composition of the present invention can be used in agriculture in the same manner as a conventional pesticidal composition.

Claims (11)

1. A pesticidal composition characterized by containing a crystal grain of a pesticidal active ingredient having a volume median particle diameter of less than 1 μm and a water-soluble polymer.
2. The pesticidal composition according to claim 1, wherein the pesticidal active ingredient is 0.1 to 50.0 parts by mass and the water-soluble polymer is 0.1 to 20.0 parts by mass based on 100 parts by mass of the pesticidal composition.
3. The pesticidal composition according to claim 1 or 2, wherein the mass ratio of the pesticidal active ingredient to the water-soluble polymer is 1: 0.05 to 100.
4. The pesticidal composition according to any one of claims 1 to 3, wherein the solubility of the pesticidal active ingredient in water is 100ppm or less.
5. A pesticidal composition according to any one of claims 1 to 4 wherein the water-soluble polymer is polyvinylpyrrolidone.
6. The pesticidal composition according to any one of claims 1 to 5, which is in the form of a suspension.
7. The pesticidal composition according to any one of claims 1 to 5, which is in the form of granules.
8. A method for producing a pesticidal composition, characterized by comprising the steps of:
a step of pulverizing the crystal grains of the agricultural chemical active ingredient to a volume median diameter of less than 1 μm; and
a step of mixing the crystal grains of the pesticidal active ingredient with a water-soluble polymer before or after the pulverization step.
9. The production method according to claim 8, wherein the pesticidal active ingredient and the water-soluble polymer are mixed at a mass ratio of 1: 0.05 to 100.
10. The production method according to claim 8 or 9, wherein the pulverization step is wet pulverization, and the method comprises a step of obtaining an agricultural chemical composition in a suspension.
11. A method for producing a pesticidal composition, comprising the steps of: a granular pesticidal composition obtained by granulating a mixture obtained by mixing the suspension-form pesticidal composition obtained by the production method according to claim 10 with a powder containing a solid carrier.
CN202080075301.4A 2019-10-28 2020-10-27 Pesticide composition and method for producing same Pending CN114615889A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510976717.8A CN120898801A (en) 2019-10-28 2020-10-27 Pesticide Compositions and Methods for Manufacturing Them

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-195254 2019-10-28
JP2019195254 2019-10-28
PCT/JP2020/040156 WO2021085395A1 (en) 2019-10-28 2020-10-27 Agrochemical composition and method for producing same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202510976717.8A Division CN120898801A (en) 2019-10-28 2020-10-27 Pesticide Compositions and Methods for Manufacturing Them

Publications (1)

Publication Number Publication Date
CN114615889A true CN114615889A (en) 2022-06-10

Family

ID=75715982

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202080075301.4A Pending CN114615889A (en) 2019-10-28 2020-10-27 Pesticide composition and method for producing same
CN202510976717.8A Pending CN120898801A (en) 2019-10-28 2020-10-27 Pesticide Compositions and Methods for Manufacturing Them

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202510976717.8A Pending CN120898801A (en) 2019-10-28 2020-10-27 Pesticide Compositions and Methods for Manufacturing Them

Country Status (4)

Country Link
JP (1) JP7628500B2 (en)
KR (1) KR20220090524A (en)
CN (2) CN114615889A (en)
WO (1) WO2021085395A1 (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009184969A (en) * 2008-02-06 2009-08-20 Sds Biotech Corp Agrochemical granule
CN101547608A (en) * 2006-10-03 2009-09-30 巴斯夫欧洲公司 Liquid insecticide compositions containing N-phenylsemicarbazone insecticide compounds
JP2012197243A (en) * 2011-03-22 2012-10-18 Sumitomo Chemical Co Ltd Herbicide composition and method for controlling weed
JP2013224271A (en) * 2012-04-20 2013-10-31 Hokko Chem Ind Co Ltd Ipfencarbazone-containing granular composition
CN105010383A (en) * 2015-08-01 2015-11-04 华中农业大学 Insecticidal composition containing dinotefuran and indoxacarb and preparation method thereof
JP2016160195A (en) * 2015-02-27 2016-09-05 アグロカネショウ株式会社 Aqueous dispersion formulation containing sterilization component
US20160330953A1 (en) * 2013-12-23 2016-11-17 Dow Global Technologies Llc Pymetrozine suspension concentrates and its preparation method
JP2017075144A (en) * 2015-10-15 2017-04-20 三井化学アグロ株式会社 Aqueous suspended agrochemical composition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3276186B2 (en) 1991-12-26 2002-04-22 クミアイ化学工業株式会社 Stabilized herbicide composition
JP3756551B2 (en) 1994-07-29 2006-03-15 三菱レイヨン株式会社 Antistatic UV curable coating material and optical disc using the same
JPH1025202A (en) 1996-07-08 1998-01-27 Hokko Chem Ind Co Ltd How to control rice pests
KR20000026206A (en) 1998-10-19 2000-05-15 정선종 Computer system for visually handicapped person to search information in internet
JP2004103481A (en) 2002-09-12 2004-04-02 Bena:Kk Manufacturing method of three-dimensional light emitting plate, and three-dimensional light emitting plate
GB0613925D0 (en) * 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
EP2061323B1 (en) * 2006-10-03 2016-06-29 Basf Se Liquid pesticide composition containing n-phenylsemicarbazone pesticide compounds
JP5993333B2 (en) 2013-03-29 2016-09-14 住友化学園芸株式会社 Insecticidal composition for home gardening
US11918589B2 (en) 2016-04-28 2024-03-05 Nippon Chemiphar Co., Ltd. Medicament for treatment of multiple sclerosis
TWI841568B (en) * 2018-06-08 2024-05-11 日商日本化藥股份有限公司 Wettable pesticide compositions
US20210153502A1 (en) * 2018-07-11 2021-05-27 Sanyo Chemical Industries, Ltd. Plant growth aid and plant growing method

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101547608A (en) * 2006-10-03 2009-09-30 巴斯夫欧洲公司 Liquid insecticide compositions containing N-phenylsemicarbazone insecticide compounds
JP2009184969A (en) * 2008-02-06 2009-08-20 Sds Biotech Corp Agrochemical granule
JP2012197243A (en) * 2011-03-22 2012-10-18 Sumitomo Chemical Co Ltd Herbicide composition and method for controlling weed
JP2013224271A (en) * 2012-04-20 2013-10-31 Hokko Chem Ind Co Ltd Ipfencarbazone-containing granular composition
US20160330953A1 (en) * 2013-12-23 2016-11-17 Dow Global Technologies Llc Pymetrozine suspension concentrates and its preparation method
JP2016160195A (en) * 2015-02-27 2016-09-05 アグロカネショウ株式会社 Aqueous dispersion formulation containing sterilization component
CN105010383A (en) * 2015-08-01 2015-11-04 华中农业大学 Insecticidal composition containing dinotefuran and indoxacarb and preparation method thereof
JP2017075144A (en) * 2015-10-15 2017-04-20 三井化学アグロ株式会社 Aqueous suspended agrochemical composition

Also Published As

Publication number Publication date
KR20220090524A (en) 2022-06-29
JP7628500B2 (en) 2025-02-10
CN120898801A (en) 2025-11-07
JPWO2021085395A1 (en) 2021-05-06
WO2021085395A1 (en) 2021-05-06

Similar Documents

Publication Publication Date Title
EP3453257B1 (en) Herbicidal agrochemical composition and herbicidal method using same
AU2019369551B2 (en) Microcapsule composition, method for manufacturing same, agrochemical formulation comprising same and weed control method
JP7397802B2 (en) Microcapsule composition and method for producing the same, agrochemical formulation containing the same, and weed control method
CN107920507A (en) Granular agrichemical composition
EP3384774B1 (en) Agrochemical composition and dispersal method therefor
KR20170115602A (en) Granular pesticide composition and method for manufacturing same
CN114615889A (en) Pesticide composition and method for producing same
JP7664845B2 (en) Weed control method and mixed pesticide composition for soil treatment
KR20160145614A (en) Large granular agrochmical composition that floats on water surface and production method therefor
KR102350438B1 (en) Granular pesticide composition and manufacturing method thereof
CA3154594C (en) Method of inhibiting and/or reducing crop injury caused by absorption into cultivated crops, with pyroxasulfone that is microencapsulated or coated with a masking substance
KR20220004017A (en) Granular pesticide composition and spraying method thereof
JP2025075873A (en) Granular pesticide composition and method for producing same
JP2025075872A (en) Granular pesticide composition and method for producing same
JP2025075359A (en) Granular pesticide composition
JP2017109963A (en) Method for producing finely divided pesticide composition
CA3225746A1 (en) Aqueous suspension agrochemical composition, disease control method, and useful plant seeds

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination