CN1140064A

CN1140064A - Formula and producing method for lactogenic finger citron oral preparation

Info

Publication number: CN1140064A
Application number: CN 95107231
Authority: CN
Inventors: 夏永潮; 陈俊仁
Original assignee: Guangzhou Baiyunshan Pharmaceutical Co Ltd
Current assignee: Guangzhou Baiyunshan Pharmaceutical Co Ltd
Priority date: 1995-07-07
Filing date: 1995-07-07
Publication date: 1997-01-15

Abstract

An oral medicine for promoting milk secretion of puerperant is prepared from 11 Chinese-medicinal materials such as Chinese angelica root, Chuan-Xiong rhizome, astragalus root, epimedium, motherwork, etc. through alcohol extraction, water extraction, filtering, concentration, and addition of sugar and excipient, and features high effect by nourishing blood and promoting circulation, and the curative action on other postpartum diseases.

Description

The prescription of lactogenic finger citron oral preparation and production method

The present invention relates to a kind of Chinese medicine preparation, particularly a kind of a kind of increasing milk agent for the treatment of hypogalactia of lying-in woman.

For a long time, China people have the good tradition that nourishes the baby on mother's milk, owing to be subjected to the influence of various factors, and breastfeeding rate constantly decline in the big city over year surplus in the of nearly ten, and gradually to small and medium-sized cities, small towns and rural area expansion.In being unfavorable for breastfeeding factor, puerperal hypogalactia (accounting for puerpera 20%～30%) is one of key factor.As everyone knows, the breast milk comprehensive nutrition contains the required various materials of infants growth and development, and is easy to digestion and absorption; Also contain many immune factors in breast milk, the baby can improve its anti pathologic immunity power after absorbing.Therefore recover the normal lactogenic function of puerpera, improve breastfeeding rate, have great and profound significance the anthropometic level that improves Chinese children.Motherland's medical science has far-reaching history to the research of hypogalactia of lying-in woman problem, generally speaking is dialectical deficiency and excess, and the branch another matter is controlled, the treatment of deficiency-syndrome by reinforcement, Sheng person dredges it, promptly treats the hypogalactia of all void of QI and blood with the method that fills blood, with the hypogalactia of the soothing the liver strongly fragrant method relieving stagnation of QI and the depress liver that looses, and assistant is with the agent of lactogenesis.But there are many weak points in traditional lactogenic prescription, as: 1. many not deficiency and excesss are taken into account, thereby fail to accomplish treating both the principal and secondary aspects of a disease.2. in the tradition side use the animal drug Squama Maniss and Squama Manis is rare the watching for animals of national two classes, the source of goods is in short supply, can not satisfy the medication needs more.3. traditional prescription is many without strict subject design and clinical verification.

The objective of the invention is that deficiency and excess is taken into account, nourishing-to-relaxing, mend, dredge and combine with lactogenesis, make the puerpera of deficiency of both QI and blood rebuild one's physical constitution rapidly, the stagnation of QI due to depression of the liver person is able to catharsis, thus increase cesarean lactation amount.

The present invention realizes by following mode: with foshousan (Radix Angelicae Sinensis, Rhizoma Chuanxiong) is principal agent, and reuses Radix Angelicae Sinensis, enriches blood and invigorates blood circulation, be aided with Radix Astragali air making-up and spleen enlivening, the prosperous blood of gas given birth to, to change fresh milk, in strongly invigorating QI and blood, assistant with Herba Epimedii, Herba Leonuri, Rhizoma Polygonati, Semen Vaccariae, medicines such as Medulla Tetrapanacis, Radix Bupleuri, Radix Glycyrrhizae, get its dispersing the stagnated live-QI to relieve the stagnation of QI, the kidney invigorating and essence nourishing, active lactogenesis must be mended puerpera's QI and blood vital essence, the mechanism of qi catharsis has system, harmonious towards appointing, source foot ruton, milk are certainly down.On production technology, the active ingredient in the above-mentioned prescription through alcohol extraction, filtration, concentrated, is added glucose and makes oral liquid or syrup, can be made into tablet, capsule, large and small honeyed pill or granule etc. behind the adding excipient, conveniently to take.This preparation except that curing mainly hypogalactia of lying-in woman or hypogalactia, to puerperal other miscellaneous diseases good efficacy is also arranged.Carry out 113 routine clinical verifications through units such as Gansu Provincial Hospital of Traditional Chinese Medicine, Gansu Province healthcare hospital for women ﹠ children, attached institutes of Medical Colleges of the Inner Mongol, total effective rate is more than 88%.

Below enforcement of the present invention is described in further detail:

Prescription is formed and consumption (percentage by weight):

Amount ranges (%) optimum amount (%) Radix Angelicae Sinensis 5.50-32.96 27.47 Ligusticum wallichii 2.75-5.50 4.39 Radix Astragali 5.5-27.47 24.72 barrenwort 3.85-8.24 6.60 motherwort 4.39-8.80,6.60 sealworts (steaming) 5.50-16.48 10.99 seeds of cowherb (stir-fry) 3.29-8.24 5.50 stem pith of the rice-paper plant 2.75-6.60 4.94 radix bupleuri 3.85-7.70 5.50 Radix Glycyrrhizae 2.75-5.50 3.29 production technologies:

With in the ethanol of measuring Radix Angelicae Sinensis, Rhizoma Chuanxiong adding 30-70% concentration, divide second extraction by prescription, filter, reclaim under reduced pressure ethanol, fluid extract is standby.All the other 8 flavor medicines such as its medicinal residues and the Radix Astragali, Herba Epimedii add decocting in water to be carried three times, is concentrated into clear paste after the filtration, and other gets and mixes with clear paste after liquid glucose boils, and temperature is reduced to about 60 ℃, with above-mentioned fluid extract mix homogeneously, promptly.Said products can further be concentrated into dried cream, adds excipient, makes oral formulations such as capsule or tablet.

The present invention's preparation has the QI invigorating of nourishing blood, and is soothing the liver diffusing strongly fragrant, and benefit has significant curative effect through the effect of lactogenesis to treating puerpera's hypogalactia or hypogalactia and puerperal complicated cases.

Embodiment 1:

Get Radix Angelicae Sinensis 27.47%, Rhizoma Chuanxiong 4.39%, the Radix Astragali 24.72%, Herba Epimedii 6.6%, Herba Leonuri 6.6%, Rhizoma Polygonati 10.99%, Semen Vaccariae 5.5%, Medulla Tetrapanacis 4.94%, Radix Bupleuri 5.5%, Radix Glycyrrhizae 3.29%.

Its production technology is:

Radix Angelicae Sinensis, Rhizoma Chuanxiong adds an amount of secondary altogether that extracts of ethanol of 30-70% concentration, filtration, decompression, recovered alcohol, and it is standby to get its fluid extract.8 flavor medicines such as the medicinal residues and the Radix Astragali, Herba Epimedii, Herba Leonuri, Rhizoma Polygonati, Semen Vaccariae, Medulla Tetrapanacis, Radix Bupleuri, Radix Glycyrrhizae add decocting in water and carry three times, filter, be concentrated into clear paste, other gets and mixes with clear paste after liquid glucose boils, the temperature of waiting is reduced to about 60 ℃, fluid extract mix homogeneously with Radix Angelicae Sinensis, Rhizoma Chuanxiong, the fluid extract of gained mixing is concentrated into dried cream, adds excipient again, make oral formulations such as capsule or tablet.

Embodiment 2:

Get Radix Angelicae Sinensis 27.47%, Rhizoma Chuanxiong 4.39%, the Radix Astragali 24.72%, Herba Epimedii 6.6%, Herba Leonuri 6.6%, Rhizoma Polygonati 10.99%, Semen Vaccariae 8%, Medulla Tetrapanacis 4.94%, Radix Bupleuri 4%, Radix Glycyrrhizae 2.75%.Production technology such as embodiment 1.

Embodiment 3:

Get Radix Angelicae Sinensis 27.47%, Rhizoma Chuanxiong 4.39%, the Radix Astragali 24.72%, Herba Epimedii 8%, Herba Leonuri 6.6%, Rhizoma Polygonati 9.59%, Semen Vaccariae 5.5%, Medulla Tetrapanacis 4.94%, Radix Bupleuri 5.5%, Radix Glycyrrhizae 3.29%.Production technology such as embodiment 1.

Embodiment 4:

Get Radix Angelicae Sinensis 30.47%, Rhizoma Chuanxiong 4.39%, the Radix Astragali 21.72%, Herba Epimedii 6.6%, Herba Leonuri 6.6%, Rhizoma Polygonati 10.99%, Semen Vaccariae 5.5%, Medulla Tetrapanacis 4.94%, Radix Bupleuri 5.5%, Radix Glycyrrhizae 3.29%.Production technology such as embodiment 1.

Embodiment 5:

Get Radix Angelicae Sinensis 27.47%, Rhizoma Chuanxiong 3.39%, the Radix Astragali 24.72%, Herba Epimedii 6.6%, Herba Leonuri 8.6%, Rhizoma Polygonati 10.99%, Semen Vaccariae 5.5%, Medulla Tetrapanacis 4.94%, Radix Bupleuri 4.5%, Radix Glycyrrhizae 3.29%.Production technology such as embodiment 1.

Claims

1, a kind of lactogenic finger citron oral preparation, formed by Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Astragali, Herba Epimedii, Herba Leonuri, Rhizoma Polygonati, Semen Vaccariae, Medulla Tetrapanacis, Radix Bupleuri, Radix Glycyrrhizae, be it is characterized in that the proportioning of above-mentioned prescription is (percentage by weight): Radix Angelicae Sinensis 5.50-32.96, Rhizoma Chuanxiong 2.75-5.50, Radix Astragali 5.5-27.47, Herba Epimedii 3.85-8.24, Herba Leonuri 4.39-8.80, Rhizoma Polygonati (steaming) 5.50-16.48, Semen Vaccariae (stir-fry) 3.29-8.24, Medulla Tetrapanacis 2.75-6.60, Radix Bupleuri 3.85-7.70, Radix Glycyrrhizae 2.75-5.50.

2, lactogenic finger citron oral preparation according to claim 1 is characterized in that the best prescription (percentage by weight) of this increasing milk agent is: Radix Angelicae Sinensis 27.47, Rhizoma Chuanxiong 4.39, the Radix Astragali 24.72, Herba Epimedii 6.60, Herba Leonuri 6.60, Rhizoma Polygonati (steaming) 10.99, Semen Vaccariae (stir-fry) 5.50, Medulla Tetrapanacis 4.94, Radix Bupleuri 5.50, Radix Glycyrrhizae 3.29.

3, a kind of production technology of lactogenic finger citron oral preparation, it is characterized in that getting Radix Angelicae Sinensis by the dosage (percentage by weight) of prescription, the ethanol that Rhizoma Chuanxiong adds 30-70% concentration extracts secondary in right amount, filter, reclaim under reduced pressure ethanol, it is standby to get its fluid extract, its medicinal residues and the Radix Astragali, Herba Epimedii, Herba Leonuri, Rhizoma Polygonati, Semen Vaccariae, Medulla Tetrapanacis, Radix Bupleuri, Radix Glycyrrhizae adds decocting in water and carries three times, filter, be concentrated into clear paste, other gets and mixes with clear paste after liquid glucose boils, the temperature of waiting is reduced to about 60 ℃, with Radix Angelicae Sinensis, the fluid extract mix homogeneously of Rhizoma Chuanxiong, the blended fluid extract of gained is concentrated into dried cream, adds excipient again, make oral formulations such as capsule or tablet.