CN103784163A - Liver fat quantitative system based on ultrasonic - Google Patents
Liver fat quantitative system based on ultrasonic Download PDFInfo
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- CN103784163A CN103784163A CN201410026902.2A CN201410026902A CN103784163A CN 103784163 A CN103784163 A CN 103784163A CN 201410026902 A CN201410026902 A CN 201410026902A CN 103784163 A CN103784163 A CN 103784163A
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Abstract
The invention relates to a liver fat quantitative system based on ultrasonic. The liver fat quantitative system comprises an ultrasonic generator, an ultrasonic receiver, an ultrasonic echo brightness level value acquisition module, an ultrasonic attenuation coefficient acquisition module, an intensity ratio acquisition module for acquiring the liver and kidney echo intensity ratio H, and a liver fat quantitative module. The ultrasonic generator transmits pulse ultrasonic to the liver; the ultrasonic receiver receives echo signals of ultrasonic; the ultrasonic echo brightness level value acquisition module acquires a brightness level value of a liver far field region and a brightness level value of a near field region; the ultrasonic attenuation coefficient acquisition module acquires liver echo attenuation coefficients, and liver fat quantitative detection is conducted through the liver and kidney echo intensity ratio H and the liver echo attenuation coefficients. According to the technical scheme, the liver echo attenuation coefficients can be more accurately calculated through the image brightness level value acquired by the liver ultrasonic echo signals, and the liver fat quantitative detection is conducted through the liver and kidney echo intensity ratio H and the liver echo attenuation coefficients. The liver fat quantitative system is convenient and easy to use, practical, accurate and reliable.
Description
Technical field
The present invention relates to a kind of liver fat measuring system, relate in particular to a kind of liver fat quantitative system based on ultrasonic echo.
Background technology
Along with the development of ultrasonic technique, utilize the development of ultrasonic technique and medical skill, the requirement that hepatic lesions is carried out to noninvasive test more and more becomes the emphasis of research.Prior art detects and many estimates qualitatively by ultrasonoscopy for liver fat, also has the research of carrying out ultrasonic attenuation coefficient and carry out quantitative analysis, but due to for somatometry, in ultrasonic attenuation coefficient computational process, there is the impact of scattering and diffraction, therefore
Be difficult to determine its compensation method.Therefore, in liver fat quantitative detection system, relatively effective method few.
Summary of the invention
The technical problem that the present invention solves is: build a kind of liver fat measuring system, overcome prior art and lack compared with the technical problem of effective method in calculating ultrasonic attenuation coefficient and Fat quantification testing process.
Technical scheme of the present invention is: build a kind of liver fat quantitative system based on ultrasonic, comprise supersonic generator, ultrasonic receiver, ultrasonic echo luminance level value acquisition module, ultrasonic attenuation coefficient acquisition module, obtain Liver and kidney echo intensity than the strength ratio acquisition module of H, the quantitative module of liver fat, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic echo luminance level value acquisition module obtains the luminance level value of this liver far-field region and the luminance level value of near-field region, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, described ultrasonic attenuation coefficient acquisition module obtains ultrasonic attenuation coefficient a according to following formula:
Wherein: a represents liver echo attenuation coefficient, A
nand A
fbe respectively liver near field area-of-interest luminance level value and liver far field area-of-interest luminance level value, Δ d represents the distance between liver far-field region and near-field region, and f represents ultrasound echo signal frequency; The quantitative module of described liver fat obtains hepatic fat content according to following formula: S=63H+168a-28, and wherein S represents hepatic fat content, a represents liver echo attenuation coefficient.
Further technical scheme of the present invention is: also comprise ultrasound echo signal noise signal removal module, described ultrasound echo signal noise signal is removed module the ultrasonic signal receiving is removed to noise signal.
Further technical scheme of the present invention is: described ultrasonic echo luminance level value acquisition module also comprises ultrasonic signal is carried out to envelope curve matching, chooses the far-field region of described liver and the near-field region of described liver according to the curve of matching.
Technique effect of the present invention is: build a kind of liver fat quantitative system based on ultrasonic, comprise supersonic generator, ultrasonic receiver, ultrasonic echo luminance level value acquisition module, ultrasonic attenuation coefficient acquisition module, obtain Liver and kidney echo intensity than the strength ratio acquisition module of H, the quantitative module of liver fat, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic echo luminance level value acquisition module obtains the luminance level value of this liver far-field region and the luminance level value of near-field region, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, by Liver and kidney echo intensity than H and liver echo attenuation coefficient to liver fat detection by quantitative.The brightness of image level value that the art of this patent scheme obtains by the ultrasound echo signal of liver, calculates liver echo attenuation coefficient more accurately, then by Liver and kidney echo intensity to when liver echo attenuation coefficient to liver fat detection by quantitative.Facilitate simple and practical, accurately and reliably.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Fig. 2 is the oscillogram of liver ultrasonic echo luminance level value of the present invention and the degree of depth.
The specific embodiment
Below in conjunction with specific embodiment, technical solution of the present invention is further illustrated.
As shown in Figure 1, the specific embodiment of the present invention is: build a kind of liver fat quantitative system based on ultrasonic, comprise supersonic generator 1, ultrasonic receiver 2, ultrasonic echo luminance level value acquisition module 3, ultrasonic attenuation coefficient acquisition module 4, obtain Liver and kidney echo intensity than the strength ratio acquisition module 5 of H, the quantitative module 6 of liver fat, described supersonic generator 1 is to liver position emission pulse ultrasonic, described ultrasonic receiver 2 receives hyperacoustic echo signal, described ultrasonic echo luminance level value acquisition module 3 obtains the luminance level value of this liver far-field region and the luminance level value of near-field region, described ultrasonic attenuation coefficient acquisition module 4 obtains liver echo attenuation coefficient, described ultrasonic attenuation coefficient acquisition module 4 obtains ultrasonic attenuation coefficient a according to following formula:
Wherein: a represents liver echo attenuation coefficient, A
nfor liver near field area-of-interest luminance level value, A
ffor liver far field area-of-interest luminance level value, Δ d represents the distance between liver far-field region and near-field region, and f represents ultrasound echo signal frequency; The quantitative module 6 of described liver fat obtains hepatic fat content according to following formula: S=63H+168a-28, and wherein S represents hepatic fat content, a represents liver echo attenuation coefficient.
As shown in Figure 1 and Figure 2, specific embodiment of the invention process is: described supersonic generator 1 is to liver position emission pulse ultrasonic, and described ultrasonic receiver 2 receives hyperacoustic echo signal, from the ultrasonic echo signal receiving.In the time that the sound wave of transmitting is pulse ultrasonic wave, by receiving liver ultrasound echo signal, in the image of its formation, form luminance level value according to ultrasonic echo intensity, and ultrasonic echo intensity is exponential damping in certain medium,, ultrasonic luminance level value is exponential damping in certain medium, that is:
A
n=A
0×e
a×f×d, （1）
Wherein, A
n, A
0the luminance level value that is respectively two certain depth ultrasound echo signals formation images, a represents ultrasonic echo attenuation quotient, and f is that hyperacoustic frequency occurs supersonic generator 1, and d is that sound source is to the distance of surveying thing certain depth.
When described supersonic generator 1 is to liver position emission pulse ultrasonic, described ultrasonic receiver 2 receives hyperacoustic echo signal, as shown in Figure 2, and A
nfor liver near field area-of-interest luminance level value, A
ffor liver far field area-of-interest luminance level value, that is, and A
nfor the integral area of liver near field area-of-interest, A
ffor the integral area of liver far field area-of-interest.Thus, the ratio that can derive liver near field area-of-interest luminance level value and liver far field area-of-interest luminance level value is:
A
n/A
f=e
a×f×△d
Wherein: A
nfor liver near field area-of-interest luminance level value, A
ffor liver far field area-of-interest luminance level value, a represents ultrasonic echo attenuation quotient, and f is that hyperacoustic frequency occurs supersonic generator 1, △ d be liver far field area-of-interest and liver near field area-of-interest along sound field the distance difference apart from sound source.
By mathematic(al) manipulation, obtain:
So far, obtain ultrasonic echo attenuation quotient.
Adopt [
1h] in the experiment of hepatic fat content measured of NMR (Nuclear Magnetic Resonance) spectrum, ultrasonic Liver and kidney echo ratio is the strongest to the predictive ability of hepatic fat content.By [
1h] experiment of hepatic fat content measured of NMR (Nuclear Magnetic Resonance) spectrum, known ultrasonic Liver and kidney echo ratio and ultrasonic liver echo attenuation coefficient and hepatic fat content are linear, by introducing 3D simulation human abdomen model, ultrasonic Liver and kidney echo ratio and liver echo attenuation coefficient are carried out to standardization, by adopting multiple linear regression analysis screening from the using ultrasonic quantitative index of each body measurement parameter and markization to can be used for estimating the main quantitative parameter of liver fat.Concrete acquisition methods is: first set up the linear equation about ultrasonic Liver and kidney echo ratio and ultrasonic liver echo attenuation coefficient and hepatic fat content, that is: and C=xH+ya+z, wherein, x, y, z is linear equation coefficient.Simulate human abdomen's models for several times by 3D and measure hepatic fat content, ultrasonic Liver and kidney echo ratio and ultrasonic liver echo attenuation coefficient, get its meansigma methods, can obtain linear equation coefficient x, y, z, wherein, linear equation coefficient x, y, z is also quantitative parameter, forms hepatic fat content computing formula by these quantitative parameters and liver echo attenuation coefficient:
S=63H+168a-28, wherein S represents hepatic fat content, a represents liver echo attenuation coefficient.
Strength ratio acquisition module 5 obtains respectively the echo intensity of liver and the echo intensity of kidney, then obtains its ratio H.Thus: obtain hepatic fat content by ultrasonic Liver and kidney echo ratio and liver echo attenuation coefficient.
As shown in Figure 1, the preferred embodiment of the present invention is: also comprise ultrasound echo signal noise signal removal module, described ultrasound echo signal noise signal is removed module the ultrasonic signal receiving is removed to noise signal, and the image border that the ultrasound echo signal receiving is formed is more level and smooth.
As shown in Figure 1, the preferred embodiment of the present invention is: described ultrasonic echo luminance level value acquisition module 3 also comprises ultrasonic signal is carried out to envelope curve matching, chooses the far-field region of described liver and the near-field region of described liver according to the curve of matching.
Technique effect of the present invention is: build a kind of liver fat quantitative system based on ultrasonic, comprise supersonic generator 1, ultrasonic receiver 2, ultrasonic echo luminance level value acquisition module 3, ultrasonic attenuation coefficient acquisition module 4, obtain Liver and kidney echo intensity than the strength ratio acquisition module 5 of H, the quantitative module 6 of liver fat, described supersonic generator 1 is to liver position emission pulse ultrasonic, described ultrasonic receiver 2 receives hyperacoustic echo signal, described ultrasonic echo luminance level value acquisition module 3 obtains the luminance level value of this liver far-field region and the luminance level value of near-field region, described ultrasonic attenuation coefficient acquisition module 4 obtains liver echo attenuation coefficient, described ultrasonic attenuation coefficient acquisition module 4 obtains ultrasonic attenuation coefficient a according to following formula:
Wherein: a represents liver echo attenuation coefficient, A
nfor liver near field area-of-interest luminance level value, A
ffor liver far field area-of-interest luminance level value, Δ d represents the distance between liver far-field region and near-field region, and f represents ultrasound echo signal frequency; The quantitative module 6 of described liver fat obtains hepatic fat content according to following formula: S=63H+168a-28, and wherein S represents hepatic fat content, a represents liver echo attenuation coefficient.The brightness of image level value that technical solution of the present invention obtains by the ultrasound echo signal of liver, calculates liver echo attenuation coefficient more accurately, then by Liver and kidney echo intensity to when liver echo attenuation coefficient to liver fat detection by quantitative.Facilitate simple and practical, accurately and reliably.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.
Claims (3)
1. the liver fat quantitative system based on ultrasonic, it is characterized in that, comprise supersonic generator, ultrasonic receiver, ultrasonic echo luminance level value acquisition module, ultrasonic attenuation coefficient acquisition module, obtain the strength ratio acquisition module of Liver and kidney echo intensity ratio, the quantitative module of liver fat, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic echo luminance level value acquisition module obtains the luminance level value of this liver far-field region and the luminance level value of near-field region, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, described ultrasonic attenuation coefficient acquisition module obtains ultrasonic attenuation coefficient a according to following formula:
Wherein: a represents liver echo attenuation coefficient, A
nand A
fbe respectively liver near field area-of-interest luminance level value and liver far field area-of-interest luminance level value, Δ d represents the distance between liver far-field region and near-field region, and f represents ultrasound echo signal frequency; The quantitative module of described liver fat obtains hepatic fat content according to following formula: S=63H+168a-28, and wherein S represents hepatic fat content, and a represents liver echo attenuation coefficient, and H represents Liver and kidney echo intensity ratio.
2. the liver fat quantitative system based on ultrasonic according to claim 1, is characterized in that, also comprises that ultrasound echo signal noise signal removes module, and described ultrasound echo signal noise signal is removed module the ultrasonic signal receiving is removed to noise signal.
3. the liver fat quantitative system based on ultrasonic according to claim 1, it is characterized in that, described ultrasonic echo luminance level value acquisition module also comprises ultrasonic signal is carried out to envelope curve matching, chooses the far-field region of described liver and the near-field region of described liver according to the curve of matching.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873221A (en) * | 2015-06-05 | 2015-09-02 | 无锡海斯凯尔医学技术有限公司 | Ultrasonic-based liver fat quantification method and system |
| CN107261345A (en) * | 2017-06-29 | 2017-10-20 | 哈尔滨医科大学 | A kind of method that utilization ultrasonic reflection echo measures internal sound field in real time |
| CN105930665B (en) * | 2016-04-26 | 2018-06-29 | 北京工业大学 | A kind of liver fat method for quantitative measuring based on ultrasonic attenuation coefficient |
| CN110604595A (en) * | 2019-05-21 | 2019-12-24 | 深圳迈瑞生物医疗电子股份有限公司 | A fatty liver quantitative analysis method and fatty liver quantitative analysis system |
| CN111050631A (en) * | 2017-08-01 | 2020-04-21 | 安德拉生命科学公司 | Method and system for estimating a subject's fat content fraction |
| CN113227782A (en) * | 2018-12-24 | 2021-08-06 | 安德拉生命科学公司 | Method and system for estimating fractional fat content of an object of interest |
| CN114557724A (en) * | 2020-11-27 | 2022-05-31 | 深圳迈瑞生物医疗电子股份有限公司 | Ultrasonic imaging apparatus and parameter measurement method |
| CN119138923A (en) * | 2023-06-16 | 2024-12-17 | 深圳迈瑞生物医疗电子股份有限公司 | Ultrasonic imaging apparatus and ultrasonic imaging method |
| CN119423832A (en) * | 2023-08-07 | 2025-02-14 | 中慧医学成像(深圳)有限公司 | Muscle three-dimensional imaging analysis method and system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104873221A (en) * | 2015-06-05 | 2015-09-02 | 无锡海斯凯尔医学技术有限公司 | Ultrasonic-based liver fat quantification method and system |
| CN105930665B (en) * | 2016-04-26 | 2018-06-29 | 北京工业大学 | A kind of liver fat method for quantitative measuring based on ultrasonic attenuation coefficient |
| CN107261345A (en) * | 2017-06-29 | 2017-10-20 | 哈尔滨医科大学 | A kind of method that utilization ultrasonic reflection echo measures internal sound field in real time |
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| CN113227782A (en) * | 2018-12-24 | 2021-08-06 | 安德拉生命科学公司 | Method and system for estimating fractional fat content of an object of interest |
| CN110604595A (en) * | 2019-05-21 | 2019-12-24 | 深圳迈瑞生物医疗电子股份有限公司 | A fatty liver quantitative analysis method and fatty liver quantitative analysis system |
| CN110604595B (en) * | 2019-05-21 | 2024-07-23 | 深圳迈瑞生物医疗电子股份有限公司 | A fatty liver quantitative analysis method and a fatty liver quantitative analysis system |
| CN114557724A (en) * | 2020-11-27 | 2022-05-31 | 深圳迈瑞生物医疗电子股份有限公司 | Ultrasonic imaging apparatus and parameter measurement method |
| CN114557724B (en) * | 2020-11-27 | 2025-06-24 | 深圳迈瑞生物医疗电子股份有限公司 | Ultrasonic imaging device and parameter measurement method |
| CN119138923A (en) * | 2023-06-16 | 2024-12-17 | 深圳迈瑞生物医疗电子股份有限公司 | Ultrasonic imaging apparatus and ultrasonic imaging method |
| CN119423832A (en) * | 2023-08-07 | 2025-02-14 | 中慧医学成像(深圳)有限公司 | Muscle three-dimensional imaging analysis method and system |
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Application publication date: 20140514 |