CN103536687B - A kind of health product improving sleep - Google Patents

Abstract

The invention discloses a health care product for improving sleep. The formula of the invention contains kudzu root, which is compatible with longan, wild jujube kernel, polygala, and baiziren, and follows the principle of syndrome differentiation and treatment in traditional Chinese medicine. The effect of sleep; in addition to the effect of improving sleep, it can also alleviate the symptoms of patients with cardiovascular and cerebrovascular diseases such as hypertension, hyperlipidemia, hyperglycemia and migraine. For some middle-aged and elderly people, it can also help treat the elderly Sexual dementia, mental retardation, poor memory, poor metabolism and other diseases.

Description

A health product for improving sleep

technical field

The invention relates to a health product, in particular to a health product for improving sleep, and belongs to the field of health products.

Background technique

Relevant studies have shown that: lack of sleep has the following hazards: (1) affects the creative thinking of the brain: such as long-term lack of sleep will affect the brain's creative thinking and ability to deal with things; (2) affects the growth and development of adolescents: the growth of adolescents Growth has a certain relationship with the secretion of growth hormone, and the secretion of growth hormone is closely related to sleep. After a person is asleep, there is a large peak of growth hormone secretion, followed by several small peaks of secretion. Hormone secretion decreases; (3) Affects skin health: Adequate sleep will enable people's skin to obtain good metabolism, lack of sleep will cause skin capillary stasis, and circulation will be blocked, so that skin cells will not receive sufficient nutrition, thus Accelerate the aging of the skin, make the skin look dull and pale, prone to dark circles and wrinkles; (4) cause diseases: frequent lack of sleep or sleep disturbance will affect the normal division of cells, and make people feel anxious and anxious. Immunity is reduced, which will lead to various diseases, such as neurasthenia, colds, gastrointestinal diseases, etc., and may even cause cancer cell mutations; The decrease in concentration can cause the increase of the concentration of appetite hormone in the human body at the same time.

Because people have different pressures from all sides in their social life, sleep problems have become a common phenomenon among "sub-healthy" people. In response to sleep problems that are becoming more and more common, people have developed health care products for improving sleep, some with traditional Chinese medicine as the main component, and some with Western medicine as the main component. With the advancement of technology and the development of technology, The preparation forms of health products are also emerging in an endless stream, such as oral liquid, tablet, granule, decoction pieces and so on.

For example, patent ZL200910040342.5 discloses a sleep-improving tablet, the active ingredient of which is made of raw materials in the following weight ratio: Albizia Julibrissin 15-20, Cypress Kernel 20-25, Polygala 10-15G, Keel 10-15 , Oyster 15-20, Lily 20-25, Jujube 15-20, Polygonum vine 15-20, Yejiao 15-20, Scrophulariaceae 5-10, Salvia miltiorrhiza 10-20, Gastrodia elata 5-10, Peanut 10- 15. Cinnabar 1-3; patent CN1171620C discloses a health food for improving sleep, which is prepared from jujube seed, schisandra, peony root, ganoderma, and ginseng; , donkey-hide gelatin, Polygala, Baiziren, roasted licorice, lily, and white peony root to nourish the heart and spleen, nourish blood and calm the nerves, and improve sleep oral liquid; patent CN100562327C discloses a health food for improving sleep and its preparation method. The health care product is made of walnut oil, schisandra, gynostemma, eleuthero, and jujube seed respectively through alcohol extraction, vacuum concentration under reduced pressure, and drying to obtain dry high powder of the extracts of schisandra, gynostemma, eleuthero, and jujube seed. Made by mixing well with walnut oil.

As the aging society becomes more and more serious, the sleep problems of middle-aged and elderly people have also received attention. Some of the existing health care products add tonic precious Chinese herbal medicines, such as ganoderma lucidum, American ginseng, ginseng, etc., which are expensive but have little effect. Improper use of these products can also lead to some potential dangers. , such as too slow or too fast metabolism, sudden rise and fall of blood pressure, etc.; some use more than ten or twenty kinds of Chinese herbal medicines, which are relatively complicated, the preparation process is cumbersome, and there are deficiencies such as incomplete extraction of active ingredients or inaccurate curative effects, etc. .

Contents of the invention

The purpose of the present invention is to provide a sleep-improving health care product for the deficiencies of the prior art. Its formula contains kudzu root, which is compatible with longan, wild jujube kernel, polygala, and baiziren. It follows the principle of syndrome differentiation and treatment in traditional Chinese medicine, and formulates various medicines. They complement each other and have obvious effects on improving sleep; in addition to improving sleep, they can also alleviate the symptoms of patients with cardiovascular and cerebrovascular diseases such as hypertension, hyperlipidemia, hyperglycemia and migraine, and for some middle-aged and elderly people, It can help treat senile dementia, mental retardation, poor memory, poor metabolism and other diseases.

In order to solve the above problems, the technical solution adopted in the present invention is: a health care product for improving sleep, which is composed of the following raw materials or their extracts in parts by weight: 3-50 parts of longan, 2-50 parts of Zianzaoren, 1 part of kudzu root -10 parts, Polygala 0.5-20 parts, Baiziren 0.5-20 parts.

The preferred weight ratio of each raw material or its extract is: 3-32 parts of longan, 2-35 parts of jujube seed, 1-8 part of kudzu root, 0.5-15 part of polygala, and 0.5-10 part of cypress kernel.

A preferred kudzu root extract is kudzu root isoflavones.

The health food is made into soft capsules, hard capsules, granules, tablets or oral liquids by adding the auxiliary materials required for the preparation of different preparations by conventional techniques.

The preparation method of the health care product for improving sleep function of the present invention can use water as a solvent to heat-extract longan, jujube kernels, polygala, and cypress kernels together for 2-3 times, then filter to obtain the extract, and then Mix with kudzu root extract.

The kudzu root extract is preferably kudzu root isoflavones obtained by solvent extraction or commercially available kudzu root isoflavones.

The preparation method of the health care product for improving sleep function of the present invention can also use water as a solvent to heat-extract longan, jujube kernels, polygala, and cypress kernels together for 2-3 times, then filter to obtain the extract, and concentrate , to make a solid liquid extract, and then mix the liquid extract with Pueraria root to granulate.

The preparation method of the health care product for improving sleep function of the present invention can also adopt traditional extraction methods respectively, such as decoction method, reflux extraction method, percolation method, etc. to obtain the extracts of various raw materials in the formula, and then Mix according to the said proportion, then adopt the conventional preparation process of the preparation, add auxiliary materials such as emulsifier, disintegrant, binder, regulator, etc. to prepare pharmaceutically acceptable health care products in different dosage forms.

The effect of main component of the present invention or the effect that plays are as follows:

(1) Longan, aliases: Yizhi, Bimu, Lychee Nu, Sublychee, Wooden Ball, Lizhu, Swallow Egg, Shark Tears, Round Eyes, Honey Spleen, Yuanyan Rou, etc. Sapindaceae longan The genus (Dimocarpus), longan flesh is sweet and warm in nature, homecoming, and spleen meridian. It is suitable for patients with deficiency of both heart and spleen and qi and blood. Contains protein, fat, sugar, organic acid, crude fiber and various vitamins and minerals. Longan meat can inhibit lipid peroxidation and increase the activity of antioxidant enzymes, suggesting that it has a certain anti-aging effect; longan meat can improve the immune function of the body, inhibit tumor cells, reduce blood lipids, increase coronary blood flow, and enhance body quality. ;

(2) Suanzaoren, also known as Zaoren, Shanzao, Suanzaoren, nature and flavor: sweet, flat; meridians: heart meridian; spleen meridian; liver meridian; gallbladder meridian, function: calming the mind and nerves; nourishing the liver; suppressing sweat. : Deficiency, restlessness and insomnia; palpitations and palpitations; physical weakness, spontaneous sweating, night sweats. Suanzaoren nourishes the liver, calms the heart, soothes the nerves, and suppresses sweating. Effects: sedative, hypnotic, analgesic, anticonvulsant effects; certain antihypertensive effect; excitatory effect on the uterus; used for deficiency of yin and blood, palpitations, insomnia and forgetfulness; physical weakness and sweating;

(3) Radix Puerariae, sweet and pungent in nature and flavor, neutral, meridian return: enters the spleen and stomach meridian; has the functions of clearing away heat, reducing fire, and detoxification. Functions and indications: promoting yang and relieving muscle, penetrating rash and stopping diarrhea, eliminating restlessness and stopping temperature, and treating typhoid fever , Warm headache, strong neck, irritability and thirst, diarrhea, dysentery, impervious rash, high blood pressure, angina pectoris, deafness; Hyperglycemia and cardiovascular and cerebrovascular diseases have a certain effect;

(4) Polygala, aliases: bitter polygala, thorn, thorn garden, small grass root bark, fine grass root bark, etc., warm in nature, bitter, pungent, slightly warm, Guixin, kidney, lung meridian, has the functions of calming the mind, eliminating phlegm, The function of reducing swelling is used for insomnia, dreaminess, forgetfulness, palpitations, trance, coughing up phlegm, sore swelling, epilepsy, convulsions, carbuncle sores, breast swelling and pain caused by heart-kidney disharmony;

(5) Baiziren, aliases: Baiziren, Bairen, Baizi, Baishi, Arborvitae, Baimai, Baizirenshuang, Cedar, sweet in nature, flat in taste, Guixin, kidney, and large intestine meridian, mainly for nourishing the heart and calming the nerves , laxative. For fatigue and insomnia, palpitations, intestinal dryness and constipation embolism.

The beneficial effect of the present invention relative to prior art is:

(1) The formula of the present invention is simple, the compatibility is reasonable, and it follows the principle of syndrome differentiation and treatment in traditional Chinese medicine. The various medicines in the formula complement each other. It has been proved by animal experiments that it has obvious sleep-improving effects, is non-toxic and harmless to the human body, and has the effect of improving immunity. Health care effect, high product safety, can be prepared into different dosage forms of health care products for improving sleep by using conventional preparation methods of medically approved preparations;

(2) Due to the use of kudzu root or its extract in the formula, which contains more than 20 kinds of isoflavones, puerarin, triterpenoids, alkaloids and other active ingredients, this health product is also suitable for people with high blood pressure, For patients with cardiovascular and cerebrovascular diseases such as hyperlipidemia, hyperglycemia and migraine, after taking a certain course of treatment, the sleep effect of the above-mentioned patients is improved, and their symptoms can also be alleviated. For some middle-aged and elderly people, in addition to improving their sleep disturbance , can also help to treat senile dementia, mental retardation, poor memory, poor metabolism and other diseases.

detailed description

The present invention will be described in further detail below through examples, and these examples are only used to illustrate the present invention, and do not limit the scope of the present invention.

Embodiment 1 adopts the following steps to prepare health product (oral liquid) of the present invention by following raw material:

(1) Prepare the raw materials as follows: 300g longan, 200g jujube seed, 100g kudzu root, 50g polygala, 50g baiziren;

(2) Extraction preparation: the preferred weight ratio of each raw material or its extracts is: longan, wild jujube kernel, polygala, and baiziren are placed in the extraction tank together, and water 5 times the weight of the raw material is added, soaked for 1 hour , heated to 100°C, kept at this temperature for decocting for 1 hour, filtered to obtain the first extraction filtrate, then added water 5 times the weight of raw medicinal materials into the extraction tank, soaked for 1 hour, heated to 95°C, kept at this Decocting at high temperature for 2 hours, filtering to obtain the second extraction filtrate; then mixing with Pueraria root extract, Pueraria isoflavones are obtained by solvent extraction;

(3) Mix the obtained extract mixture with kudzu root isoflavone evenly, fill it with 10ml/bottle, and then sterilize at high temperature to prepare the oral liquid.

Embodiment 2 adopts the following steps to prepare health product (granule) of the present invention by following raw material:

(1) Prepare the raw materials as follows: 80g longan, 40g jujube seed, 60g kudzu root, 100g polygala, 100g baiziren;

(2) Extraction preparation: longan, wild jujube kernels, polygala, and baiziren are put together in an extraction tank, add water 4 times the weight of the raw materials, soak for 2 hours, heat to 100°C, and decoct at this temperature for 1 hour. Filtrate to obtain the first extraction filtrate, then add water 5 times the weight of raw medicinal materials to the extraction tank, soak for 1 hour, heat to 100°C, keep decocting at this temperature for 2 hours, filter to obtain the second extraction filtrate ;

(3) The two extracts were combined, concentrated at a temperature of 70°C and a vacuum of 0.06Mpa until the specific gravity of the liquid was 1.15 when measured at 55°C to obtain a liquid extract;

(4) After washing and drying the kudzu root, coarsely pulverize it and pass through a 16-mesh sieve to obtain a coarse powder;

(5) The liquid extract and pueraria pueraria powder are granulated, dried, granulated, mixed, and packaged by conventional techniques.

Embodiment 3 adopts following steps to prepare health product (capsule) of the present invention by following raw material:

(1) Prepare the raw materials as follows: 100g longan, 100g jujube seed, 20g kudzu root, 40g polygala, 40g baiziren;

(2) Extraction preparation: longan, wild jujube kernels, polygala, and baiziren are placed in the extraction tank together, add water 4 times the weight of raw medicinal materials, soak for 1 hour, heat to 100°C, and decoct at this temperature for 1 hour, Filtrate to obtain the first extraction filtrate, then add water 4 times the weight of raw medicinal materials to the extraction tank, soak for 1 hour, heat to 100°C, keep decocting at this temperature for 2 hours, filter to obtain the second extraction filtrate ; Add water that is 4 times the weight of raw medicinal materials, soak for 0.5 hours, heat to 100°C, keep decocting at this temperature for 1 hour, filter, and obtain the third extraction filtrate;

(3) The three extracts were combined, concentrated at a temperature of 80°C and a vacuum of 0.05Mpa until the specific gravity of the liquid was 1.2 when measured at 50°C to obtain a liquid extract;

(4) After washing and drying the kudzu root, coarsely pulverize it and pass through a 14-mesh sieve to obtain a coarse powder;

(5) The liquid extract and pueraria pueraria powder were mixed and granulated by conventional techniques, talcum powder and magnesium stearate were added, and filled into hard capsule preparations.

Claims (2)

1. A health product for improving sleep, characterized in that: the health product granule prepared by the following steps using the following raw materials: (1) Prepare the raw materials as follows: 80g longan, 40g jujube seed, 60g kudzu root, 100g polygala, 100g baiziren; (2) Extraction preparation: longan, wild jujube kernels, polygala, and baiziren are put together in an extraction tank, add water 4 times the weight of the raw materials, soak for 2 hours, heat to 100°C, and decoct at this temperature for 1 hour. Filtrate to obtain the first extraction filtrate, then add water 5 times the weight of raw medicinal materials to the extraction tank, soak for 1 hour, heat to 100°C, keep decocting at this temperature for 2 hours, filter to obtain the second extraction filtrate ; (3) The two extracts were combined, concentrated at a temperature of 70°C and a vacuum of 0.06Mpa until the specific gravity of the liquid was 1.15 when measured at 55°C to obtain a liquid extract; (4) After washing and drying the kudzu root, coarsely pulverize it and pass through a 16-mesh sieve to obtain a coarse powder; (5) The liquid extract and pueraria pueraria powder are granulated, dried, granulated, mixed, and packaged by conventional techniques. 2. A health care product for improving sleep, characterized in that: the health care product capsule prepared by the following steps using the following raw materials: (1) Prepare the raw materials as follows: 100g longan, 100g jujube seed, 20g kudzu root, 40g polygala, 40g baiziren; (2) Extraction preparation: longan, wild jujube kernels, polygala, and baiziren are placed in the extraction tank together, add water 4 times the weight of raw medicinal materials, soak for 1 hour, heat to 100°C, and decoct at this temperature for 1 hour, Filtrate to obtain the first extraction filtrate, then add water 4 times the weight of raw medicinal materials to the extraction tank, soak for 1 hour, heat to 100°C, keep decocting at this temperature for 2 hours, filter to obtain the second extraction filtrate ; Add water that is 4 times the weight of raw medicinal materials, soak for 0.5 hours, heat to 100°C, keep decocting at this temperature for 1 hour, filter, and obtain the third extraction filtrate; (3) The three extracts were combined, concentrated at a temperature of 80°C and a vacuum of 0.05Mpa until the specific gravity of the liquid was 1.2 when measured at 50°C to obtain a liquid extract; (4) After washing and drying the kudzu root, coarsely pulverize it and pass through a 14-mesh sieve to obtain a coarse powder; (5) The liquid extract and pueraria pueraria powder were mixed and granulated by conventional techniques, talcum powder and magnesium stearate were added, and filled into hard capsule preparations.