CN103301377A - Natural pharmaceutical composition - Google Patents
Natural pharmaceutical composition Download PDFInfo
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- CN103301377A CN103301377A CN2013102713935A CN201310271393A CN103301377A CN 103301377 A CN103301377 A CN 103301377A CN 2013102713935 A CN2013102713935 A CN 2013102713935A CN 201310271393 A CN201310271393 A CN 201310271393A CN 103301377 A CN103301377 A CN 103301377A
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- radix scutellariae
- semen alpiniae
- alpiniae katsumadai
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- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 claims abstract description 52
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- 239000000284 extract Substances 0.000 claims abstract description 36
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 29
- 206010012735 Diarrhoea Diseases 0.000 claims abstract description 28
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 claims abstract description 20
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims abstract description 20
- 229960003321 baicalin Drugs 0.000 claims abstract description 20
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 claims abstract description 20
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- 239000003814 drug Substances 0.000 claims description 53
- 210000000582 semen Anatomy 0.000 claims description 51
- 229940079593 drug Drugs 0.000 claims description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 43
- 238000002360 preparation method Methods 0.000 claims description 35
- 239000000706 filtrate Substances 0.000 claims description 21
- 229930003944 flavone Natural products 0.000 claims description 20
- 150000002213 flavones Chemical class 0.000 claims description 20
- 235000011949 flavones Nutrition 0.000 claims description 20
- 238000009835 boiling Methods 0.000 claims description 19
- 239000012467 final product Substances 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 14
- 239000012153 distilled water Substances 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 10
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- 230000008030 elimination Effects 0.000 claims description 5
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- 230000006837 decompression Effects 0.000 claims description 4
- 238000003810 ethyl acetate extraction Methods 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
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- 238000006243 chemical reaction Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 15
- 241000050051 Chelone glabra Species 0.000 abstract 2
- 235000013421 Kaempferia galanga Nutrition 0.000 abstract 2
- 244000062241 Kaempferia galanga Species 0.000 abstract 2
- 229930003935 flavonoid Natural products 0.000 abstract 1
- 150000002215 flavonoids Chemical class 0.000 abstract 1
- 235000017173 flavonoids Nutrition 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 9
- 229960004397 cyclophosphamide Drugs 0.000 description 9
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- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
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- HAWSQZCWOQZXHI-FQEVSTJZSA-N 10-Hydroxycamptothecin Chemical compound C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-FQEVSTJZSA-N 0.000 description 1
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- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a natural pharmaceutical composition. The natural pharmaceutical composition comprises a katsumade galangal seed and baical skullcap root water decoction concentrated extract, a katsumade galangal seed ethyl acetate extract, total flavonoids of baical skullcap root and baicalin according to the proportion of (2-4): (3-8): (3-9): (1-4), and the composition has an excellent curative effect against diarrhea which is related to cancer chemotherapy and can simultaneously realize a synergistic action against the cancer chemotherapy.
Description
Technical field
The present invention relates to a kind of natural drug composition, relate more specifically to a kind of natural drug composition that is comprised of Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones and baicalin, the preparation method of this natural drug composition and this natural drug composition are for the preparation of reducing the cancer chemotherapy induced diarrhea and treatment of cancer being played purposes in the medicine of potentiation.
Background technology
Malignant tumor is current harm humans existence, one of healthy principal disease, and its treatment means comprises operation, chemotherapy, radiotherapy, Chinese medicine, and the effect of chemotherapeutic treatment tumor is particularly outstanding.Chemotherapeutic is no matter alone or unite with the toxicity such as all can cause that the patient suffers from diarrhoea, and diarrhoea is again Chemotherapy-induced Diarrhea behind the chemotherapy of tumors.In recent years emerging and applying along with chemotherapeutics such as 5-fluorouracil, taxanes, hydroxy camptothecin, irinotecan, xeloda etc., the incidence rate of Chemotherapy-induced Diarrhea improves year by year, if do not carry out active treatment, easily cause patient's dehydration, malnutrition, serum electrolyte disorder, acid base imbalance etc., it is unfavorable greatly not only the rehabilitation of body to be brought, also bring certain difficulty to CC, therefore effective treatment of Chemotherapy-induced Diarrhea has been become the important component part of tumor patient wholistic therapy.
Chemotherapy-induced Diarrhea is with regard to its clinical manifestation, surely belongs to the Chinese medicine category of " having loose bowels ", and Chinese medicine attracts people's attention for the research of having loose bowels, but there is no at present the Chinese patent medicine that the antagonism cancer chemotherapy has alleviating diarrhoea and potentiation.Therefore, research and develop a kind of high-efficiency low-toxicity, cheap, the natural Chinese medicine that can be used for alleviating the cancer chemotherapy induced diarrhea and playing the chemotherapeutic sensitivity effect that is easy to promote becomes clinical problem demanding prompt solution.
Semen Alpiniae Katsumadai is the seed of zingiberaceous plant Semen Alpiniae Katsumadai.Main feeling of fullness is done diseases such as expanding, vomit, have loose bowels.Radix Scutellariae is the root of labiate Radix Scutellariae, cures mainly dysentery.In recent years, Semen Alpiniae Katsumadai and Radix Scutellariae antitumaous effect are confirmed, the inventor is through research and the experiment of each a large amount of formula proportion, obtained at last optimal drug ratio compositions of the present invention, and proved that it has fabulous curative effect and can simultaneously to chemotherapeutic sensitivity, finish thus the present invention the cancer chemotherapy induced diarrhea.
Summary of the invention
A kind of natural drug composition provided by the invention is made of in the ratio of 2-4:3-8:3-9:1-4 by weight Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones and baicalin.
Above-mentioned natural drug composition, wherein the usage ratio of Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones and baicalin is 4:8:9:4.
Wherein, Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones can obtain by well known to a person skilled in the art that conventional method is purified, and the natural drug of the present invention that the one-tenth of buying that conventional method obtains or commercial is grouped into all can obtain identical curative effect.
Preferably, the preparation method of Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract is in the above-mentioned natural drug composition:
Be 1-4 according to proportion compatibility: 1 gets Semen Alpiniae Katsumadai, Radix Scutellariae, distilled water immersion, and heating decocts, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating is concentrated, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure and get final product.
The preparation method of Semen Alpiniae Katsumadai ethyl acetate extract is in the above-mentioned natural drug composition:
Semen Alpiniae Katsumadai is pulverized, and sieves, and 70% alcohol heating reflux extracts 3 times, and decompression and solvent recovery gets dry extract, and extractum is put to room temperature after being diluted to suspension with hot water, with ethyl acetate extraction, reclaims solvent, and drying is pulverized, and sieves, and get final product.
The Radix Scutellariae total flavones preparation method is in the above-mentioned natural drug composition:
Get the Radix Scutellariae coarse powder, 55% alcohol reflux repeatedly filters, merging filtrate, and Recycled ethanol, concentrated, dry, and get final product.
The baicalin preparation method is in the above-mentioned natural drug composition:
The Radix Scutellariae crushing screening takes by weighing in right amount, extracts at twice merging filtrate, Recycled ethanol with 80% ethanol, add an amount of distilled water, add concentrated hydrochloric acid and transfer pH3-4, leave standstill elimination impurity, filtrate is transferred pH1.5-2 in 40 ℃, insulation 30min, sucking filtration, precipitation is washed to pH6.5-7.0, is drying to obtain.
The present invention also provides the preferred preparation method of this natural drug composition, comprising:
(1) preparation of Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract
Be 1-4 according to proportion compatibility: 1 gets Semen Alpiniae Katsumadai, Radix Scutellariae, distilled water immersion, and heating decocts, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating is concentrated, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure and get final product.
(2) preparation of Semen Alpiniae Katsumadai ethyl acetate extract
Semen Alpiniae Katsumadai is pulverized, and sieves, and 70% alcohol heating reflux extracts 3 times, and decompression and solvent recovery gets dry extract, and extractum is put to room temperature after being diluted to suspension with hot water, with ethyl acetate extraction, reclaims solvent, and drying is pulverized, and sieves, and get final product.
(3) Radix Scutellariae total flavones preparation
Get the Radix Scutellariae coarse powder, 55% alcohol reflux repeatedly filters, merging filtrate, and Recycled ethanol, concentrated, dry, and get final product.
(4) baicalin preparation
The Radix Scutellariae crushing screening takes by weighing in right amount, extracts at twice merging filtrate, Recycled ethanol with 80% ethanol, add an amount of distilled water, add concentrated hydrochloric acid and transfer pH3-4, leave standstill elimination impurity, filtrate is transferred pH1.5-2 in 40 ℃, insulation 30min, sucking filtration, precipitation is washed to pH6.5-7.0, is drying to obtain.
(5) choose in proportion Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones and baicalin, evenly mix, and get final product.
The preparation method of above-mentioned natural drug composition also comprises: the product that step (5) makes is further made capsule or the tablet that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine.
The beneficial effect of natural drug composition of the present invention aspect anti-Chemotherapy-induced Diarrhea and inhibition tumor is as follows:
1, natural drug composition of the present invention causes studies show that of diarrhea of mouse model at irinotecan: the diarrhoea reaction for the irinotecan induced mice has obvious antagonism.
2, proved that this natural drug composition can strengthen chemotherapeutics to the inhibitory action of tumor, adopted mouse tumor model, observed this natural drug composition and cyclophosphamide combined to the inhibitory action of mouse interior tumor.Studies show that: this natural drug composition can obviously increase cyclophosphamide for the inhibitory action of tumor.
3, the inventor is originally with Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, the Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones and baicalin make up, and determine consumption proportion between these components by great many of experiments, make said composition bring into play good synergism, pass through our repeatedly experimentation, ratio between each component of natural drug composition of the present invention has produced unexpected synergism when 2-4:3-8:3-9:1-4, potentiation is obvious, extraordinary effect is played in side effect, especially especially obvious when the usage ratio of each component is 4:8:9:4, this is that the inventor pays a large amount of creative works and obtains, and those of ordinary skills only can't simply obtain this being equipped with and the optimum amount ratio by disclosed content.
4, this natural drug composition Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones and each component of baicalin all can obtain by conventional means, component such as baicalin also can be buied by commerce, and such compositions itself has the convenience of acquisition, lower-cost effect.This also is the product that has splendid curative effect and higher industrial practicality concurrently that the inventor obtains by a large amount of creative work sides.
The specific embodiment
Further set forth the preparation of natural drug composition of the present invention below by embodiment and test example, with and the beneficial effect in diarrhea and antitumor, used.
Embodiment
The first step: the preparation of various extracts
(1) preparation of Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract
Be 1-4 according to proportion compatibility: 1 gets Semen Alpiniae Katsumadai, Radix Scutellariae, distilled water immersion, and heating decocts, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating is concentrated, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure and get final product.
(2) preparation of Semen Alpiniae Katsumadai ethyl acetate extract
Get the Radix Scutellariae coarse powder, 55% alcohol reflux repeatedly filters, merging filtrate, and Recycled ethanol, concentrated, dry, and get final product.
(3) Radix Scutellariae total flavones preparation
Taking by weighing the Radix Scutellariae coarse powder, place round-bottomed flask, is 55% ethanol with solid-to-liquid ratio l:8,85 ℃ of lower reflux, extract, repeatedly, filter, and merging filtrate, Recycled ethanol under Rotary Evaporators, concentrated, dry, obtain Radix Scutellariae total flavones.
(4) baicalin preparation
The Radix Scutellariae crushing screening takes by weighing in right amount, extracts at twice merging filtrate, Recycled ethanol with 80% ethanol, add an amount of distilled water, add concentrated hydrochloric acid and transfer pH3-4, leave standstill elimination impurity, filtrate is transferred pH1.5-2 in 40 ℃, insulation 30min, sucking filtration, precipitation is washed to pH6.5-7.0, is drying to obtain.
Second step: the preparation of preparation
(1) preparation of natural drug composition capsule preparations of the present invention
Take by weighing respectively Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract 16mg, Semen Alpiniae Katsumadai ethyl acetate extract 32mg, Radix Scutellariae total flavones 36mg and the baicalin 16mg of above-mentioned steps preparation, take by weighing simultaneously starch 395mg, magnesium stearate 5mg, evenly mix, be filled to capsule.
(2) preparation of natural drug composition tablet of the present invention
Take by weighing respectively Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract 16mg, Semen Alpiniae Katsumadai ethyl acetate extract 32mg, Radix Scutellariae total flavones 36mg and the baicalin 16mg of above-mentioned steps preparation, take by weighing simultaneously starch 295mg, lactose 100mg, evenly mix, with wet granulation, drying, mix with the 5mg magnesium stearate behind the granulate, be pressed into tablet.
Drug effect and pharmacology's data:
Compositions is in following test example: the usage ratio of Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones and baicalin is 4:8:9:4.Inventor's compositions that the multiple proportioning combination between 2-4:3-8:3-9:1-4 the time obtains to above-mentioned each composition usage ratio carried out with on identical experiment, find that all the natural drug composition in this amount ranges can obtain good synergism, can play good effect and the treatment of cancer is had potentiation the cancer chemotherapy induced diarrhea.Below be the pharmacodynamics data that preferred embodiment obtains:
Test example 1: the pharmacodynamic study of natural drug composition treatment Chemotherapy-induced Diarrhea effect
1, test material
(1) Semen Alpiniae Katsumadai, Radix Scutellariae is purchased from medical material market.
(2) mice, body weight 20 ± 2g, male, ad lib drinking-water before the experiment.
2, test method:
Mice is divided into 5 groups at random, and 5 every group, the A group is model group, and the B group is Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract 10g.kg
-1(being equivalent to contain the crude drug amount), the C group is Semen Alpiniae Katsumadai ethyl acetate extract 10g.kg
-1(being equivalent to contain the crude drug amount), D group Radix Scutellariae total flavones mixes 10g.kg with baicalin in the 9:4 ratio
-1(being equivalent to contain the crude drug amount), the E group is natural drug composition 10g.kg of the present invention
-1(being equivalent to contain the crude drug amount), irinotecan intraperitoneal injection (75mg/kg), continuous 4 days, copies the Chemotherapy-induced Diarrhea model at every day 1 time.B, C, D, E group with corresponding extract gavage 8 days, places metabolic cage with mice continuously, spreads white filter paper at the bottom of the cage observing the stool situation, and observes mice crissum situation and Mus tail fecal pollution situation, and in conjunction with cotton swab stimulation anus defecation, every day, observed and recorded was 2 times.Diarrhoea degree standard scoring is as follows: 0 minute: stool is normal or do not have; 1 minute: laxativeness, stool is visible slight wet soft; 2 minutes: moderate diarrhoea, stool wet and not molding.And there is slight crissum painted; 3 minutes, severe diarrhoea, watery stool is also painted with the severe crissum.
3, experimental result
Compare with model group, natural drug composition group Incidence of Diarrhea of the present invention obviously alleviates.The results are shown in Table 1.
Table 1 present composition is on mice Chemotherapy-induced Diarrhea incidence rate and scoring impact
Annotate: a is equivalent to contain the crude drug amount
Test example 2: the pharmacodynamic study of natural drug composition antitumor action of the present invention
1, experiment material
(1) Kunming mouse, body weight 20 ± 2g, ad lib drinking-water before the experiment, 24h natural light irradiation.
(2) cyclophosphamide, the permanent auspicious medical Pharmacy stock Co., Ltd in Jiangsu product.
2, test method:
To mice S
180The inhibition test of sarcoma growth
Employing was gone down to posterity 5-7 days, and well-grown milky ascites is diluted to tumor cell suspension with an amount of physiological saline solution, and cell number is 10
7/ mL, 5 every group, the right axillary fossa subcutaneous vaccination of every Mus 0.2mL(contains oncocyte 2 * 10
6Individual).The inoculation next day random packet, experimental group natural drug composition of the present invention is divided into (200,100mg/mL) two dosage groups, every Mus gavage 0.5 ml gives cyclophosphamide 10gkg simultaneously
-1D
-1Negative control group gives 0.5 mL distilled water; The positive drug group gives cyclophosphamide 10gkg
-1D
-1, successive administration 10 days.The conventional raising, drinking-water, food is not limit.Drug withdrawal next day, mice all takes off cervical vertebra puts to death, and strips subcutaneous solid tumor tumor piece, weighs, and calculates tumor control rate (%) by following formula:
Tumor control rate=(the average tumor of the matched group average tumor of heavy (C)-experimental group heavy (T))/average tumor of matched group heavy (C)
3, result of the test
Natural drug composition of the present invention is low, high dose group all can strengthen the cyclophosphamide agent with to S
180The effect of inhibition degree, especially the strongest with the high dose group effect.(such as table 2)
Table 2 natural drug composition of the present invention is to S
180The tumor inhibition effect of mice
| Group | Suppression ratio (%) |
| Cyclophosphamide | 31.5 |
| Compositions is low+cyclophosphamide | 36.9 |
| Height+cyclophosphamide | 47.2 |
Claims (5)
1. one kind is reduced the cancer chemotherapy induced diarrhea and the treatment cancer is played the natural drug composition of potentiation, it is characterized in that said composition is made of in the ratio of 2-4:3-8:3-9:1-4 by weight Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones and baicalin
Wherein the preparation method of Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract is:
Be 1-4 according to proportion compatibility: 1 gets Semen Alpiniae Katsumadai, Radix Scutellariae, distilled water immersion, and heating decocts, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating is concentrated, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure and get final product;
Wherein the preparation method of Semen Alpiniae Katsumadai ethyl acetate extract is:
Semen Alpiniae Katsumadai is pulverized, and sieves, and 70% alcohol heating reflux extracts 3 times, and decompression and solvent recovery gets dry extract, and extractum is put to room temperature after being diluted to suspension with hot water, with ethyl acetate extraction, reclaims solvent, and drying is pulverized, and sieves, and get final product;
Wherein the preparation method of Radix Scutellariae total flavones is:
Get the Radix Scutellariae coarse powder, 55% alcohol reflux repeatedly filters, merging filtrate, and Recycled ethanol, concentrated, dry, and get final product;
Wherein the preparation method of baicalin is:
The Radix Scutellariae crushing screening takes by weighing in right amount, extracts at twice merging filtrate, Recycled ethanol with 80% ethanol, add an amount of distilled water, add concentrated hydrochloric acid and transfer pH3-4, leave standstill elimination impurity, filtrate is transferred pH1.5-2 in 40 ℃, insulation 30min, sucking filtration, precipitation is washed to pH6.5-7.0, is drying to obtain.
2. natural drug composition as claimed in claim 1 is characterized in that wherein the usage ratio of Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones and baicalin is 4:8:9:4.
3. such as the preparation method of the natural drug composition of claim 1 or 2, it is characterized in that the method comprises:
(1) preparation of Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract
Be 1-4 according to proportion compatibility: 1 gets Semen Alpiniae Katsumadai, Radix Scutellariae, distilled water immersion, and heating decocts, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating is concentrated, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure and get final product;
(2) preparation of Semen Alpiniae Katsumadai ethyl acetate extract
Semen Alpiniae Katsumadai is pulverized, and sieves, and 70% alcohol heating reflux extracts 3 times, and decompression and solvent recovery gets dry extract, and extractum is put to room temperature after being diluted to suspension with hot water, with ethyl acetate extraction, reclaims solvent, and drying is pulverized, and sieves, and get final product;
(3) preparation of Radix Scutellariae total flavones
Get the Radix Scutellariae coarse powder, 55% alcohol reflux repeatedly filters, merging filtrate, and Recycled ethanol, concentrated, dry, and get final product;
(4) preparation of baicalin
The Radix Scutellariae crushing screening takes by weighing in right amount, extracts at twice merging filtrate, Recycled ethanol with 80% ethanol, add an amount of distilled water, add concentrated hydrochloric acid and transfer pH3-4, leave standstill elimination impurity, filtrate is transferred pH1.5-2 in 40 ℃, insulation 30min, sucking filtration, precipitation is washed to pH6.5-7.0, is drying to obtain;
(5) choosing in proportion Semen Alpiniae Katsumadai Radix Scutellariae water boiling concentration extract, Semen Alpiniae Katsumadai ethyl acetate extract, Radix Scutellariae total flavones evenly mixes with baicalin, and get final product.
4. the preparation method of natural drug composition as claimed in claim 3 characterized by further comprising: the product that step (5) makes is further made capsule or the tablet that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine.
5. such as the purposes of each described natural drug composition of claim 1-2 in preparing the medicine that reduces the reaction of cancer chemotherapy induced diarrhea and the treatment cancer is played potentiation.
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| KR20160001950A (en) * | 2014-06-30 | 2016-01-07 | (주)아모레퍼시픽 | Composition for skin whitening comprising scutellaria alpina extract |
| CN105596714A (en) * | 2016-01-19 | 2016-05-25 | 宁夏金太阳药业有限公司 | Pharyngitis treatment traditional Chinese medicine and preparation method and application thereof |
| CN105663649A (en) * | 2016-01-19 | 2016-06-15 | 宁夏金太阳药业有限公司 | Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160001950A (en) * | 2014-06-30 | 2016-01-07 | (주)아모레퍼시픽 | Composition for skin whitening comprising scutellaria alpina extract |
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| KR102224313B1 (en) | 2014-06-30 | 2021-03-09 | (주)아모레퍼시픽 | Composition for skin whitening comprising scutellaria alpina extract |
| CN105596714A (en) * | 2016-01-19 | 2016-05-25 | 宁夏金太阳药业有限公司 | Pharyngitis treatment traditional Chinese medicine and preparation method and application thereof |
| CN105663649A (en) * | 2016-01-19 | 2016-06-15 | 宁夏金太阳药业有限公司 | Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof |
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Application publication date: 20130918 |