CN103156603A - Epileptic seizure pre-warning device - Google Patents
Epileptic seizure pre-warning device Download PDFInfo
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- CN103156603A CN103156603A CN2012104709624A CN201210470962A CN103156603A CN 103156603 A CN103156603 A CN 103156603A CN 2012104709624 A CN2012104709624 A CN 2012104709624A CN 201210470962 A CN201210470962 A CN 201210470962A CN 103156603 A CN103156603 A CN 103156603A
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Abstract
一种癫痫发作预警仪，其特征在于包括脑电信号采集单元、图形识别单元和报警单元，脑电信号采集单元实时进行局灶性脑电信号监测；图形识别单元存储癫痫患者发作前脑电异常放电图形，识别癫痫患者预设的脑电波；报警单元与图形识别单元连接，根据监控数据发出报警信号。为了解决临床上癫痫发作无法预知和一些癫痫患者拒绝长期服用抗癫痫药物的问题，本发明对癫痫患者采用长程视频脑电监测技术，发现和掌握该患者癫痫发作前脑电改变的规律，研发一种能时时进行脑局灶部位的脑电监测、识别脑电变化及预警的便携式癫痫发作预警仪。将2-4个电极安置在相应脑区，当监测到癫痫发作前的脑电改变后，立即启动该系统预警装置，及时提醒患者癫痫要发作了，以便及时进行自我保护，干预和终止其癫痫发作，解除患者及家属对癫痫发作的担心，提高患者生活质量。
An epileptic seizure early warning device, characterized in that it includes an EEG signal acquisition unit, a pattern recognition unit and an alarm unit, the EEG signal acquisition unit monitors focal EEG signals in real time; the pattern recognition unit stores EEG abnormalities before seizures in epileptic patients The discharge pattern recognizes the preset brain waves of epilepsy patients; the alarm unit is connected with the pattern recognition unit, and sends out an alarm signal according to the monitoring data. In order to solve the clinical problem of unpredictable epileptic seizures and some epileptic patients refusing to take antiepileptic drugs for a long time, the present invention uses long-range video EEG monitoring technology for epileptic patients to discover and grasp the law of EEG changes before seizures, and develops a A portable epileptic seizure early warning device that can constantly monitor the EEG of focal brain parts, identify EEG changes and give early warning. Place 2-4 electrodes in the corresponding brain area. When the EEG changes before the seizure are detected, the early warning device of the system will be activated immediately to remind the patient that the epilepsy is about to occur, so as to protect themselves in time, intervene and terminate their epilepsy. Seizures, relieve patients and their families from worrying about epileptic seizures, and improve the quality of life of patients.
Description
Technical field
The present invention relates to a kind of epilepsy early warning system that can forecast in advance epilepsy.
Background technology
Epilepsy is one of nervous system disease common in world wide.Epilepsy is to have the lasting liability that can produce epilepsy and corresponding neural biological, cognitive, psychology occurs and the consequence of the aspect such as social is feature.Epilepsy is a clinical events, has the characteristics of repeatability, mechanical property and unpredictability, is the clinical manifestation of the abnormal supersynchronousization electrical activity of neuron paroxysmal in brain.Because the essence of epilepsy is that the paroxysmal of electrical activity of neurons is disorderly, therefore, electroencephalogram has important function in the diagnosis and treatment of epilepsy.
Repeatedly epilepsy for a long time,, having a strong impact on patient's physical and mental health, international community more and more pays close attention to the raising of Quality of Life of Epilepsy Patients, and clearly propose: the target of epilepsy therapy is to control epilepsy as far as possible, without or slight untoward reaction is only arranged, at utmost improve patients ' life quality.At present the most frequently used, the most important treatment means of epilepsy is still Drug therapy, although standard, reasonably Antiepileptic Drugs can be controlled 7O～80% epileptic's outbreak.Due to epilepsy can't foreseeability, even the patient who takes medicine without outbreak still worries the epilepsy again of can do by myself, dare not go out alone, more dare not be movable alone in public places, long-term thought pressure has a strong impact on patients ' life quality.Some patients worry the toxic and side effects of Long-term taking medicine and refuse medication, but the outbreak when again of unpredictable epilepsy, can't orthobiosis and work.Surgical operation therapy is large due to wound, dangerous high, and often leaves over part sensation, motor system dysfunction after operation, or forms the new epilepsy kitchen range that causes, and the re-initiation epilepsy makes clinically the prudent or refusal of many epileptics select operative treatment.Therefore, research and develop a kind of system of the epilepsy that can give warning in advance, in time remind the patient before outbreak, prevent the various danger that epilepsy breaks out and brings to the patient, remove the patient due to the psychological burden of worrying that constantly epilepsy produces, improve Quality of Life.
In clinical practice work, the inventor finds that some epileptics are expert in long-range VEEG observation process, and in the time of tens of seconds, obvious abnormal change has just appearred in frequency, the rhythm and pace of moving things and the waveform of epileptic's scalp EEG before epilepsy.Particularly for certain epileptic, before its epilepsy, the change of abnormal electroencephalogram has obvious mechanical property, and the epilepsy clinical episodes begins to begin paradoxical discharge with EEG and exists obvious time delay.
Summary of the invention
Can't predict in order to solve clinically epilepsy the problem of refusing the long-term taking antiepileptic with some epileptics, the invention provides a kind of portable early warning appearence of epilepsy's breakout that can carry out constantly eeg monitoring, the electricity variation of identification brain and the early warning at the focal position of brain, to overcome the main deficiency of prior art.
For realizing above purpose, implementation procedure of the present invention is as follows:
A kind of early warning appearence of epilepsy's breakout comprises eeg signal acquisition unit, Figure recognition unit and alarm unit,
The eeg signal acquisition unit carries out focal EEG signals monitoring in real time, and 2～4 antimagnetic brain electrical monitoring electrodes of eeg signal acquisition unit employing gather EEG signals;
The Figure recognition unit storage epileptic forebrain electrical anomaly discharge figure that shows effect, the brain wave that the identification epileptic presets;
Alarm unit is connected according to monitor data with the Figure recognition unit and sends alarm signal.
Epilepsy method for early warning of the present invention comprises the following steps:
(1) fix by long-range video eeg monitoring screening discharge position and discharge and clinical episodes have the epileptic of dependency;
(2) the front brain electrical anomaly discharge figure of this epileptic's clinical episodes is stored in startup Figure recognition unit, as default figure;
(3) select 2-4 antimagnetic brain electrical monitoring electrode, Real-Time Monitoring is carried out at the corresponding scalp position that is placed in epileptic's discharge;
(4) monitor default figure when the Figure recognition unit, start immediately alarm unit.
Can't predict in order to solve clinically epilepsy the problem of refusing the long-term taking antiepileptic with some epileptics, the present invention adopts long-range video eeg monitoring technology to the epileptic, find and grasp the rule that this patient's epilepsy forebrain electricity changes, research and develop a kind of portable early warning appearence of epilepsy's breakout that can carry out constantly eeg monitoring, the electricity variation of identification brain and the early warning at the focal position of brain.With 2-4 electrode arrangement in corresponding brain district; after brain electricity before monitoring epilepsy changes; start immediately this system early warning device; in time remind patient's epilepsy to show effect; in order in time carry out self-protection; intervene and stop its epilepsy, removing patient and family members to the worry of epilepsy, improving patients ' life quality.
Description of drawings
Fig. 1 is the structural representation of early warning appearence of epilepsy's breakout of the present invention.
The specific embodiment
as shown in Figure 1, the present invention includes the eeg signal acquisition unit, Figure recognition unit and alarm unit, at first fix by long-range video eeg monitoring screening discharge position and discharge and clinical episodes have the epileptic of dependency, then start the brain electrical anomaly discharge figure before this epileptic's clinical episodes is stored in the Figure recognition unit, as default figure, select 2-4 antimagnetic brain electrical monitoring electrode to be placed in the corresponding scalp position of epileptic's discharge, carry out the focal EEG signals of Real-Time Monitoring, the brain wave of presetting as Figure recognition unit identification epileptic, when monitoring default figure, start immediately alarm unit.
Application Example:
Select to possess the patient of following condition at hospital's Neurology Department eeg monitoring center, Xijing: have epilepsy in observation process at least 3 times, outbreak is the variation of the mechanical property of brain electricity appearance more than front ten seconds, and electric the change with clinical episodes of brain exists significant correlation and time to postpone.Select altogether 73 examples to possess the epileptic of above-mentioned condition, complete tetanus one clonic spasm outbreak 16 examples wherein, simple partial seizure 20 examples, complex partial seizures 28 examples, partial seizures secondary generalized seizures 9 examples.In monitoring, epilepsy patient's 23 examples (31.5%) more than 3 times, wherein have 6 routine patients epilepsy in 15 hours more than 6 times, to have 4 routine patients to show effect in 24 hours more than 9 times, the highest outbreak 18 times.This group case Video-EEG data analysis carries out jointly by 2 technical staff and Neurology Department associate chief physicians with electroencephalogram professional work experience more than 8 years, playback comprises that outbreak begins moment repeatedly, reach postictal details in outbreak, and the relation of explication de texte clinical events and corresponding electroencephalogram, finding that epilepsy is initial exists obvious time delay with abnormal electroencephalogram initial position, and wherein the abnormal EEG of 11 examples (24.4%) originates in fore head and leads after 4～15 seconds and observe onset symptoms; 12 examples (26.7%) originate in occiput and lead after 4～15 seconds and onset symptoms occurs; 14 examples (31.1%) originate in the temporo district and respectively lead 3-20 and onset symptoms occurs after second; 8 examples (17.8).It should be noted that, repeatedly frequently the show effect onset symptoms of its clinical manifestation and the change of abnormal electroencephalogram of same patient has obvious mechanical property, stage of attack abnormal EEG figure concrete manifestation: during outbreak, abnormal EEG is initial from a regional area, show as suddenly local or engender low wave amplitude fast wave or the slow wave frequency range that is different from the background brain electrical acti, or sharp, the spike rhythm and pace of moving things, its frequency and wave amplitude have recruiting phenomenon, scope enlarges to send out entirely gradually to be led, clinical epilepsy appears in the evolution process that is ictal rhythm and pace of moving things ripple after ten seconds or tens of seconds.
The inventor has therefrom screened 12 patients, male's 7 examples, women's 5 examples, 26 years old mean age, agree through the patient, for it has carried out the placement of early warning appearence of epilepsy's breakout at corresponding brain focal position, lay at present early-warning apparatus 2-6 month, without any untoward reaction relevant to laying early-warning apparatus, early warning amounts to 78 times, accuracy rate 95%.
The early warning accuracy of early warning appearence of epilepsy's breakout of the present invention is higher, have no adverse reaction, being fit to partial epilepsy uses, in time early warning epilepsy, solve the unpredictable clinical difficult problem of epilepsy, solve the inconvenience of worrying constantly the life and work that epilepsy brings for the patient, improve Quality of Life of Epilepsy Patients.
Claims (3)
1. early warning appearence of epilepsy's breakout is characterized in that comprising eeg signal acquisition unit, Figure recognition unit and alarm unit,
The eeg signal acquisition unit carries out focal EEG signals monitoring in real time;
The Figure recognition unit storage epileptic forebrain electrical anomaly discharge figure that shows effect, the brain wave that the identification epileptic presets;
Alarm unit is connected with the Figure recognition unit, sends alarm signal according to monitor data.
2. early warning appearence of epilepsy's breakout according to claim 1, is characterized in that: 2～4 antimagnetic brain electrical monitoring electrodes collection EEG signals of eeg signal acquisition unit employing.
3. the method for early warning of early warning appearence of epilepsy's breakout claimed in claim 1 is characterized in that comprising the following steps:
(1) fix by long-range video eeg monitoring screening discharge position and discharge and clinical episodes have the epileptic of dependency;
(2) the front brain electrical anomaly discharge figure of this epileptic's clinical episodes is stored in startup Figure recognition unit, as default figure;
(3) select 2-4 antimagnetic brain electrical monitoring electrode, be placed in the corresponding scalp position of epileptic's discharge, carry out Real-Time Monitoring;
(4) monitor default figure when the Figure recognition unit, start immediately alarm unit.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173045A (en) * | 2014-08-15 | 2014-12-03 | 浙江大学医学院附属第二医院 | Epileptic seizure prewarning system |
| CN104622468A (en) * | 2013-11-14 | 2015-05-20 | 先健科技(深圳)有限公司 | Deep brain stimulation system with predication function |
| CN106983593A (en) * | 2017-04-20 | 2017-07-28 | 贵州省人民医院 | A kind of protection treatment system for preventing epilepsy invasion patient from injuring |
| CN108209872A (en) * | 2017-12-29 | 2018-06-29 | 佛山市幻云科技有限公司 | Epilepsy Children monitoring method, device, server and system |
| CN109567797A (en) * | 2019-01-30 | 2019-04-05 | 浙江强脑科技有限公司 | Epilepsy method for early warning, device and computer readable storage medium |
| CN110051349A (en) * | 2019-04-04 | 2019-07-26 | 上海市金山区青少年活动中心 | Epilepsy detection and alarm system and its working method |
| CN110403603A (en) * | 2019-08-07 | 2019-11-05 | 龙岩学院 | A monitoring device for assisting epilepsy surgery |
| CN110477908A (en) * | 2019-07-16 | 2019-11-22 | 华南师范大学 | A kind of method of intelligent recognition epileptogenic focus |
| CN111462887A (en) * | 2020-03-31 | 2020-07-28 | 首都医科大学宣武医院 | Wearable epileptic digital assistant system |
| CN118873089A (en) * | 2024-07-17 | 2024-11-01 | 北京理工大学 | Neuroprosthetic contact lens system for instant intraocular pressure monitoring and feedback |
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Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622468B (en) * | 2013-11-14 | 2020-04-07 | 先健科技(深圳)有限公司 | Deep brain stimulation system with external prediction function |
| CN104622468A (en) * | 2013-11-14 | 2015-05-20 | 先健科技(深圳)有限公司 | Deep brain stimulation system with predication function |
| CN104173045A (en) * | 2014-08-15 | 2014-12-03 | 浙江大学医学院附属第二医院 | Epileptic seizure prewarning system |
| CN106983593A (en) * | 2017-04-20 | 2017-07-28 | 贵州省人民医院 | A kind of protection treatment system for preventing epilepsy invasion patient from injuring |
| CN106983593B (en) * | 2017-04-20 | 2019-04-19 | 贵州省人民医院 | A protective treatment system to prevent injury in patients with epilepsy |
| CN108209872A (en) * | 2017-12-29 | 2018-06-29 | 佛山市幻云科技有限公司 | Epilepsy Children monitoring method, device, server and system |
| CN109567797A (en) * | 2019-01-30 | 2019-04-05 | 浙江强脑科技有限公司 | Epilepsy method for early warning, device and computer readable storage medium |
| CN109567797B (en) * | 2019-01-30 | 2021-10-01 | 浙江强脑科技有限公司 | Epilepsy early warning method and device and computer readable storage medium |
| CN110051349A (en) * | 2019-04-04 | 2019-07-26 | 上海市金山区青少年活动中心 | Epilepsy detection and alarm system and its working method |
| CN110477908A (en) * | 2019-07-16 | 2019-11-22 | 华南师范大学 | A kind of method of intelligent recognition epileptogenic focus |
| CN110403603A (en) * | 2019-08-07 | 2019-11-05 | 龙岩学院 | A monitoring device for assisting epilepsy surgery |
| CN110403603B (en) * | 2019-08-07 | 2023-06-23 | 龙岩学院 | A monitoring device for assisting epilepsy surgery |
| CN111462887A (en) * | 2020-03-31 | 2020-07-28 | 首都医科大学宣武医院 | Wearable epileptic digital assistant system |
| CN111462887B (en) * | 2020-03-31 | 2023-08-29 | 首都医科大学宣武医院 | A wearable digital assistant system for epilepsy patients |
| CN118873089A (en) * | 2024-07-17 | 2024-11-01 | 北京理工大学 | Neuroprosthetic contact lens system for instant intraocular pressure monitoring and feedback |
| CN118873089B (en) * | 2024-07-17 | 2025-09-09 | 北京理工大学 | Neuroprosthesis contact lens system for immediate intraocular pressure monitoring and feedback |
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Application publication date: 20130619 |