CN102743209B - Micro-invision intervened thrombus taking system - Google Patents
Micro-invision intervened thrombus taking system Download PDFInfo
- Publication number
- CN102743209B CN102743209B CN201210268532.4A CN201210268532A CN102743209B CN 102743209 B CN102743209 B CN 102743209B CN 201210268532 A CN201210268532 A CN 201210268532A CN 102743209 B CN102743209 B CN 102743209B
- Authority
- CN
- China
- Prior art keywords
- thrombosis
- millimeters
- trap setting
- thrombus
- far
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 129
- 239000000463 material Substances 0.000 claims description 36
- 229910045601 alloy Inorganic materials 0.000 claims description 17
- 239000000956 alloy Substances 0.000 claims description 17
- 238000000605 extraction Methods 0.000 claims description 14
- 238000005868 electrolysis reaction Methods 0.000 claims description 10
- 229920002635 polyurethane Polymers 0.000 claims description 9
- 239000004814 polyurethane Substances 0.000 claims description 9
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
- 229910000831 Steel Inorganic materials 0.000 claims description 6
- 229920002379 silicone rubber Polymers 0.000 claims description 6
- 239000004945 silicone rubber Substances 0.000 claims description 6
- 239000010959 steel Substances 0.000 claims description 6
- 229920002614 Polyether block amide Polymers 0.000 claims description 5
- 238000009954 braiding Methods 0.000 claims description 5
- 229910052697 platinum Inorganic materials 0.000 claims description 4
- 229910052715 tantalum Inorganic materials 0.000 claims description 4
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 3
- 239000010936 titanium Substances 0.000 claims description 3
- 229910052719 titanium Inorganic materials 0.000 claims description 3
- 238000009941 weaving Methods 0.000 claims description 3
- 239000010930 yellow gold Substances 0.000 claims description 3
- 229910001097 yellow gold Inorganic materials 0.000 claims description 3
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims 2
- 229910001000 nickel titanium Inorganic materials 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 abstract description 29
- 208000006011 Stroke Diseases 0.000 abstract description 15
- 206010008190 Cerebrovascular accident Diseases 0.000 abstract description 6
- 230000001154 acute effect Effects 0.000 abstract description 6
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 230000002490 cerebral effect Effects 0.000 abstract description 3
- 238000009940 knitting Methods 0.000 abstract 1
- 230000000250 revascularization Effects 0.000 abstract 1
- 238000013461 design Methods 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 239000011248 coating agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- 238000007917 intracranial administration Methods 0.000 description 6
- 229910001069 Ti alloy Inorganic materials 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 210000001168 carotid artery common Anatomy 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000009998 heat setting Methods 0.000 description 4
- 238000002583 angiography Methods 0.000 description 3
- 230000000916 dilatatory effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 3
- 229910052721 tungsten Inorganic materials 0.000 description 3
- 239000010937 tungsten Substances 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 206010008132 Cerebral thrombosis Diseases 0.000 description 2
- 208000005189 Embolism Diseases 0.000 description 2
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 208000001435 Thromboembolism Diseases 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 210000004004 carotid artery internal Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 229920001432 poly(L-lactide) Polymers 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 229920000052 poly(p-xylylene) Polymers 0.000 description 2
- 239000004626 polylactic acid Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 230000002537 thrombolytic effect Effects 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 241000549343 Myadestes Species 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000013156 embolectomy Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 208000037922 refractory disease Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
- Surgical Instruments (AREA)
Abstract
The invention discloses a micro-invision intervened thrombus taking system, which comprises a conveyor guide wire, a thrombus catching device, a microcatheter and a guide catheter; the thrombus catching device is a net-shaped bracket formed by knitting one or more wires, a remote end of the bracket is closed or necked, a near end thereof is opened and in the shape of cone. The net-shaped bracket can sleeve relatively big main thrombus and also catch stripped small thrombus, so as to prevent small thrombus flowing to the blood vessel at remoter end and largely reduce the possibility of secondary stroke. The head end of the guide catheter is soft and can be expanded by the thrombus to obtain larger thrombus. The fracture resistance and the flexibility of the remote end of the guide catheter are largely improved, therefore, the guide catheter can be conveyed to the blood vessel at remoter end. The net-shaped bracket is also used as a bracket and reserved in a narrow-section blood vessel to expand the blood vessel and dredge the blood flow, therefore, the additional function of the disease is eased. By using the system, the operation time can be saved to win the treatment time for patients with acute cerebral apoplexy stoke, thus the success rate of the revascularization of the patients is improved.
Description
Technical field
The present invention relates to a kind of Wicresoft and get involved thrombosis extraction system, belong to technical field of medical instruments.
Background technology
Apoplexy is the refractory disease of most serious harm human health and life security, reaches 2,200,000, annual stroke patient dead 1,500,000 according to the annual patient with cerebral apoplexy that occurs of statistics China.Now survival stroke patient 8,000,000, wherein 6,000,000 patients disability and can't take care of oneself in various degree.The expense that patient with cerebral apoplexy is hospitalized for treatment is high, at least several ten thousand RMB, at most the even near million people people's coin of hundreds of thousands.For the patient of apoplexy delivering to hospital in time, conventional therapeutic scheme is medicine thrombolytic, but the effective ingredient of a lot of medicine is difficult to reach lesion, thus does not reach predetermined treatment object.Secondly, the widow time (disease is dealt into the time obtained medical treatment) that medicine melts bolt the best is within 4 hours, because China overwhelming majority patient stays in small and medium-sized cities and rural area, they exceed this time period often after delivering to the hospital of certain treatment ability, therefore in the disability rate of China's apoplexy up to 75%.
In recent years, carried out acute cerebral thrombosis gradually in some hospitals of European and American developed countries and got involved embolectomy, compare with conventional medicine thrombolytic, the interventional method used time is short, risk is low, take up rate height (can up to 90%), the more important thing is widow time can extend to disease send out after 8 hours.The acute thrombus extraction system that the most American-European doctor accepts now is the Solitaire FR Device of ev3 company of the U.S. and the Merci Retrieval Device of Concentric Medical company of the U.S..The using method of the two is almost consistent, and whole apparatus is received in an external diameter less than in the microtubular of 1 millimeter.During intervene operation, cover has the microtubular of this apparatus to push thrombosis by doctor, and then release core apparatus, this device just can entangle thrombosis like this.And start slowly to withdraw microtubular, the thrombosis entangled is transferred in the larger guiding catheter of internal diameter.But the two has common several large shortcoming in actual clinical uses,
1) the two does not all have distal vessels design protection, has microthrombus and peel off from main body and flow to the blood vessel of more far-end in using, thus the blood vessel that blocking is more tiny, cause second stroke, even jeopardize patients ' lives.
2), when running into the thrombosis that volume is comparatively large and quality is comparatively hard, broken little thrombosis be cut or be cut into thrombosis extruding all cannot by these two kinds of apparatuses above, and less thrombosis relatively easily takes out.
3) internal diameter of the 8F guiding catheter of these two kinds of systems more than is all 2 millimeters, and the diameter that cerebral thrombosis has is up to 4 millimeters, if the lucky quality of this thrombosis is hard, this thrombosis just cannot pull 8F guiding catheter into.Doctor has to thrombosis slowly to haul out tiny cerebrovascular, and blood vessel diameter becomes large gradually in the process, and thrombosis is easy to slippage, blocks other blood vessels, runs into such predicament, very large to patient's harm.
4) if patient's section angiostenosis is serious, doctor needs to withdraw from whole device after being taken out by thrombosis, then implements operation again, places expandable stent, narrow section vasodilation is played the effect of dredging blood flow.Get thrombosis and implement stent procedure and separately perform, operation is complicated, and operating time is long, has a big risk to patient.
Summary of the invention
Technical problem to be solved by this invention is to provide.
For solving the problems of the technologies described above, the invention provides a kind of Wicresoft and getting involved thrombosis extraction system, comprising delivery guidewire, it is characterized in that, also comprise microtubular, guiding catheter, the thrombosis trap setting that links together with delivery guidewire far-end,
Described thrombosis trap setting is the network woven by single or multi-filament material, and the far-end of support becomes closing structure or throat structure, and cancellated near-end is open tapered, and the vertebra angle that axis is formed gets involved 0 degree to 75 degree;
The inside diameter ranges of microtubular is 0.2 millimeter to 3 millimeters; External diametrical extent is 0.5 millimeter to 4 millimeters, and length range is 20 centimetres to 300 centimetres;
Guiding catheter inside diameter ranges is 1 millimeter to 10 millimeters; External diametrical extent is 2 millimeters to 15 millimeters.Length range is 20 centimetres to 300 centimetres.
Described network structure shape is semi-closed shelf-like, netted, basket or open stent shape.
The silk material diameter range weaving described thrombosis trap setting is 10 microns to 1 millimeter;
The cancellated diameter range formed after braiding is 1 millimeter to 30 millimeters;
It is 1 millimeter to 100 millimeters that described netted (or basket shape or support) structure opens rear length range
It is 20 centimetres to 200 centimetres with the delivery guidewire length that thrombosis trap setting links together.
Described braided support with the material of the silk material fastening rack far end is:
Tweezer titanium alloy, cochrome, rustless steel, pure platinum or its alloy, true yellow gold or its alloy, pure tungsten or its alloy, pure tantalum or its alloy, pure titanium or its alloy, degradable metal material, Biodegradable material (such as polylactic acid PLLA).
The material of the delivery guidewire that described and thrombosis trap setting is connected to is:
Tweezer titanium alloy or cochrome or rustless steel.
Described guiding catheter can be the former guiding catheter of ball.
Described guiding catheter far-end is former with ball,
The former wall thickness range of described ball is 10 microns to 1 millimeter;
The former hardness range of ball is Shore hardness 25A to 55D;
The former material of ball is polyurethane, silicone rubber or natural rubber.
Described guiding catheter head end has axial otch.
Described guiding catheter far-end has one compared with the soft head of catheter main body softness.
The wall thickness range of described soft head is 100 microns to 2 millimeters;
Soft head material is polyurethane, silicone rubber or Pebax;
Soft head hardness range is Shore hardness 50A to 72D.
Described thrombosis trap setting is that sidewall closes or network for having opening, deployable one-tenth one plane.
Described network structure can be separated with described delivery guidewire through electrolysis, thus support is released in narrow Ink vessel transfusing, plays the effect of dredging blood flow.
The beneficial effect that the present invention reaches:
1) Wicresoft of the present invention gets involved the thrombosis trap setting being provided with special protection distal vessels in thrombosis extraction system; the network structure that its far-end closes both can be entangled larger main body thrombosis; can the foreign body of thromboembolism be caused to catch the microthrombus be stripped out and other again; thus microthrombus can be avoided to flow to the blood vessel of more far-end, greatly reduce the probability of second stroke.
2) guiding catheter head end has carried out Curve guide impeller, because this soft head end can be large by thrombosis support, successfully can fix the thrombosis of diameter up to 4 millimeters.And under same experiment condition, the existing 8F guiding catheter with same external diameter commercially used all cannot fix the thrombosis of diameter more than 3.5 millimeters.Thus make the thrombosis that the potential acquisition of native system is larger.
3) the guiding catheter far-end of native system improves greatly than the fracture resistance of the guiding catheter far-end that market uses and compliance, thus can be transported to the blood vessel of more far-end.Based on this, use native system approximately can save operating time 10 to 15 minutes, for acute cerebral stroke patient wins 10 minute very valuable treatment time, increase substantially the success rate that patient vessel is led to again.
4) thrombosis trap setting of the present invention has braided support structure, if patient's section angiostenosis is serious, the thrombosis trap setting with network structure can also be retained in narrow section blood vessel as support, plays blood vessel dilating, dredges blood flow thus the adjection of alleviation disease.Use native system to save operating time, for acute cerebral stroke, patient wins treatment time, improves the success rate that patient vessel is led to again.
Accompanying drawing explanation
Fig. 1 is that the far-end of thrombosis trap setting closes the open supporting structure of near-end;
Fig. 2 is the network structure of thrombosis trap setting;
Fig. 3 is the basket structure of thrombosis trap setting;
Fig. 4 is the conventional tubular supporting structure (doublely can do the support of dredging narrow blood vessel) of thrombosis trap setting;
Fig. 5 is guiding catheter structural representation;
Fig. 6 is the network schematic diagram that sidewall has opening, deployable one-tenth one plane.
Detailed description of the invention
Below in conjunction with accompanying drawing, the invention will be further described.Following examples only for technical scheme of the present invention is clearly described, and can not limit the scope of the invention with this.
embodiment 1
Wicresoft of the present invention gets involved thrombosis extraction system and comprises delivery guidewire 1, is welded in thrombosis trap setting 2, the microtubular in delivery guidewire, a guiding catheter 3.
Wherein, the inside diameter ranges of microtubular is 0.2 millimeter to 3 millimeters; External diametrical extent is 0.5 millimeter to 4 millimeters, and length range is 20 centimetres to 300 centimetres;
Guiding catheter inside diameter ranges is 1 millimeter to 10 millimeters; External diametrical extent is 2 millimeters to 15 millimeters.Length range is 20 centimetres to 300 centimetres.
Thrombosis trap setting 2 is arranged on the far-end of delivery guidewire 1, it is the network structure woven by silk material, cancellated far-end closes (or reducing), the open design of near-end, larger main body thrombosis can be entangled, can the foreign body of thromboembolism be caused to catch the microthrombus of disengaging main body thrombosis and other again, thus microthrombus can be avoided to flow to the blood vessel of more far-end, greatly reduce the probability of second stroke.Thrombosis larger and hard for size can also be squeezed into multiple less thrombosis by this thrombosis trap setting, is beneficial to very much and is pulled in the former guiding catheter of ball by whole thrombosis.
The network structure specific constructive form of thrombosis trap setting can adopt following several scheme in the present embodiment, and those of ordinary skill in the art can recognize, also can adopt other forms of network structure in other embodiments.
1, as shown in Figure 1, its shape and structure can be the semi-closed supporting structure 210 of braiding, and far-end 213 is woven together, and forms closed reducing.Or rack far end 213 grid fastens into closing structure by a more tiny silk 215.Mount proximal end 211 is open and tapered.Preferably scheme is that rack far end grid nearer end and other positions are closeer.
Mount proximal end 211 and far-end 213 have the good developing ring 212 of one or more x-ray.Delivery guidewire 1 surface is provided with insulating coating (overlay film is the materials such as Parylene, polyurethane Polyurethane, silicone rubber or Pebax), and the pad place only welded together with support most proximal end is the segment 214 (this segment length is 0.2-5 millimeter) not having insulating coating.Under mainly containing two kinds of situations, need be separated with delivery guidewire and stay in patient's blood vessel as thrombosis trap setting: 1) patient's section angiostenosis is serious, needs there will be this narrow blood vessel of stent-expansion of certain radial support power; 2) thrombosis is in guiding catheter course of conveying proximally, run into very bending blood vessel, make the thrombosis trap setting with thrombosis be stuck in curved blood vessel section, if delivery guidewire and thrombosis trap setting are outwards removed by brute force, meeting injured patients blood vessel, causes great risk.Run into above arbitrary situation, the most proximal end (outer patient body) of delivery guidewire 1 is connected By Electrolysis device or can provide the equipment of high-frequency pulse current by doctor, do not have the segment 214 of insulating coating generally can be melted by electrolysis in one minute, support can be made like this to be separated with delivery guidewire 1 from pad, thus whole support is stayed in patient's blood vessel.
2, as shown in Figure 2, its shape can be the fishing net shaped of braiding or the structure of net bag-shaped, and far-end is formed closed, and near-end is opening.
3, as shown in Figure 3, its shape and structure can be the basket structure of braiding, and far-end is woven together to be formed and closes, proximal openings.Compare network structure trap setting, basket structure cannot capture very little thrombosis, but basket structure is simple, with low cost, the more important thing is can manufacture more tiny, thus can place and enter more tiny microtubular.More tiny microtubular (such as 1.5F) can enter the blood vessel of more tiny more far-end.And more the blood vessel diameter of far-end is generally less than 2 millimeters, this place's thrombosis is also very little, even if thrombosis is divided into more tiny multiple thrombosis in operation, the size of finally going out from basket shape fabric drain is very little, less to patient's harm.That is, the thrombosis trap setting of net basket structure is more suitable for taking out the thrombosis of the blood vessel being positioned at more tiny more far-end
4, as shown in Figure 4, its shape and structure can be open shape supporting structure 220, and the near-end side of this support is wedge shape (analysing and observe), and such structure is beneficial to the thrombosis captured.Mount proximal end 221 and far-end 223 have the good developing ring 222 of one or more x-ray, and developing ring material can be platinum, or gold, or tantalum, or tungsten, or multiple alloy.Delivery guidewire 1 surface is provided with insulating coating (overlay film is the materials such as Parylene, polyurethane Polyurethane, silicone rubber or Pebax), and the pad place only welded together with support most proximal end is the segment 24 (this segment length is 0.2-5 millimeter) not having insulating coating.If there are clinical needs, the most proximal end (outer patient body) of delivery guidewire 1 connects By Electrolysis device, do not have the segment 24 of insulating coating generally can be melted by electrolysis in one minute, support can be made like this to be separated with delivery guidewire 1 from pad, thus whole support is stayed in patient's blood vessel.Open shape supporting structure 220 far-end 223 part is conventional stent designs, and has suitable radial support power.The far-end semi-closed supporting structure of Fig. 1 design also may be used for above-mentioned occasion, because rack far end grid is fastened together to fasten silk more tiny than rack body silk, once whole system connects electrolysis unit, tiny silk of fastening can be dissolved by electrolysis very soon and holds, thus rack far end grid is no longer in bond, rack far end now becomes traditional tube-shaped structure.And after-poppet is also melted by electrolysis from pad and delivery guidewire naked section, support is separated with delivery guidewire and stays narrow blood vessel place, plays the effect of dredging blood flow.
The thrombosis trap setting of Fig. 1 and Fig. 4 design is applicable to the patient that treatment distal vessels has Serious Stenosis very much.Run into similar case, doctor is first rapid to take out the thrombosis of artery-clogging, then the thrombosis trap setting withdrawing from this supporting structure is not needed, but this support is first shunk enter microtubular, then microtubular is pushed to narrow blood vessel place, pin delivery guidewire and withdraw microtubular simultaneously, support can be discharged like this.If doctor is unsatisfied with backing positions, support can be taken in microtubular again, behind adjustment microtubular position, releasing bracket is until its position is desirable again.Finally the most proximal end of delivery guidewire is connected By Electrolysis device, within about one minute, inner support is separated from pad with delivery guidewire, withdraws from delivery guidewire and other equipment, thus whole support is stayed narrow Ink vessel transfusing, play dilating effect to narrow blood vessel.Or delivery guidewire most proximal end 211,221 is connected the equipment that can provide high-frequency pulse current, and operable electric current is between 0.2 ampere to 2 amperes clinically, and voltage is 15 to 25 volts, frequency is 150 road 350 KHz.General connection about one minute, support most proximal end 211,221 and delivery guidewire 1 position that has a common boundary will melt disconnection, thus supporting structure 210,220 is separated with delivery guidewire 1, withdraw from delivery guidewire and other equipment, thus whole support is stayed narrow Ink vessel transfusing, dilating effect is played to narrow blood vessel.
The silk material diameter range that thrombosis trap setting uses is 10 microns to 1 millimeter; Network structure open after diameter range be 1 millimeter to 30 millimeters; Opening rear length range is 1 millimeter to 100 millimeters.
The material of the silk material of braided support includes, but are not limited to following material, or in following material multiple different materials mixed weaving is out:
Tweezer titanium alloy, cochrome, rustless steel, pure platinum or its alloy, true yellow gold or its alloy, pure tungsten or its alloy, pure tantalum or its alloy, pure titanium or its alloy, degradable metal material, Biodegradable material (such as polylactic acid PLLA).
The material of the delivery guidewire that described and thrombosis trap setting is connected to is:
Tweezer titanium alloy or cochrome or rustless steel.
5, thrombosis trap setting can be conventional circular tube shaped support, as Figure 1 and Figure 4; Also can be the network that sidewall 23 has opening 230, deployable one-tenth one plane, as shown in Figure 6, sidewall 23 forms open structure, and near-end 231 side of this support is wedge shape (analysing and observe), and such structure is beneficial in the less microtubular of support income diameter.Near-end 231 and far-end 233 have the good developing ring 232 of one or more x-ray.Delivery guidewire 1 far-end is connected with the near-end 231 of support, and its surface is provided with insulating coating equally, and the pad place only welded together with support most proximal end is the segment 234 not having insulating coating.
embodiment 2
In the present embodiment, microtubular can select standard type number, and has done further improvement to guiding catheter, and all the other are identical with embodiment 1.
Curve guide impeller is carried out to guiding catheter head end, as shown in Figure 5, has had the otch 311 of about 2 mm lengths at guiding catheter 3 head end 31.
In the present invention, the guiding catheter far-end of this structure is not dribbled former, thus without the need to the special passage to the former injection fluid of ball, so do not dribble former 8F guiding catheter its when maintaining same external diameter, the internal diameter large 15% of the 8F guiding catheter more former than dribbling, thus make the thrombosis that the potential acquisition of native system is larger.
8F guiding catheter of the present invention is placed in a simulated blood vessel, because the soft head end with otch can be large by thrombosis support, successfully can fixes the hard thrombosis of diameter up to 4 millimeters.And under same experiment condition, the 8F guiding catheter that market uses all cannot fix the hard thrombosis of diameter more than 3.5 millimeters.
As shown in Figure 5, in the present invention, guiding catheter head end 31 selects the material more soft than catheter main body, is called soft head:
1) wall thickness range of soft head is 100 microns to 2 millimeters.
2) soft head material includes, but are not limited to following material, or multiple in following material: polyurethane (Polyurethane), silicone rubber, Pebax.
3) soft head hardness range is Shore hardness 25A to 72D.
The operating procedure of conventional intervention thrombosis extraction system is as follows:
1) first 6F guiding catheter is placed into the common carotid artery (Common Carotid Artery) of patient.
2) seal wire enters intracranial vessel by 6F guiding catheter, and crosses thrombosis.
3) withdraw from 6F guiding catheter, along seal wire 5F angiography catheter very soft for far-end placed and enter internal carotid artery.
4) along 5F angiography catheter, 8F guiding catheter larger for internal diameter placement is entered internal carotid artery.
5) withdraw from 5F angiography catheter, microtubular is entered intracranial vessel along seal wire, until close to thrombosis.
6) seal wire is withdrawn from.The delivery guidewire slowly pushed with thrombosis trap setting enters microtubular, intracranial vessel of slowly being made a gift to someone by thrombosis trap setting, and crosses thrombosis.
7) thrombosis trap setting is released microtubular, such thrombosis is just encased by thrombosis trap setting.
8) slowly withdraw delivery guidewire, thus thrombosis is dragged to 8F guiding catheter.
9) if thrombosis size is less, now only need be connected to 8F guiding catheter near-end connection wye place with a syringe more than 20 milliliters, the firmly former guiding catheter of suction ball, thrombosis will suck 8F guiding catheter, finally along with 8F guiding catheter is withdrawn from outside patient body together.If thrombosis size is comparatively large and quality is comparatively hard, be just difficult to successful removal of thromboses.
Compare conventional system, simple and fast is wanted in the operation of intervention thrombosis extraction system of the present invention, and concrete steps are as follows:
1) directly the guiding catheter of far-end softness is placed into the common carotid artery (Common Carotid Artery) of patient.
2) seal wire is pierced into guiding catheter, and push seal wire and enter intracranial vessel, and cross thrombosis.
3) microtubular is entered intracranial vessel along seal wire, until cross thrombosis.
4) seal wire is withdrawn from.The delivery guidewire slowly pushed with thrombosis trap setting enters microtubular, thrombosis trap setting is slowly sent into intracranial vessel, and crosses thrombosis.
5) pin the delivery guidewire welded together with thrombosis trap setting, and slowly withdraw microtubular and discharge thrombosis trap setting, such thrombosis is just encased by thrombosis trap setting.
6) slowly withdraw delivery guidewire, thus thrombosis is dragged to guiding catheter.
7) if thrombosis size is less, now only need be connected to guiding catheter near-end connection wye place with a syringe more than 20 milliliters, firmly aspirate guiding catheter, thrombosis will suck guiding catheter, finally along with guiding catheter is withdrawn from outside patient body together.If thrombosis size is larger and hard, pin guiding catheter, slowly withdraw the delivery guidewire welded together with thrombosis trap setting, about the shearing due to trap setting outer rim, thrombosis will be cut into multiple less thrombosis.Now firmly aspirate guiding catheter with a syringe more than 20 milliliters, multiple less thrombosis will suck guiding catheter, finally along with guiding catheter is withdrawn from outside patient body together.
Under simulation test condition, use system of the present invention to get thrombosis and approximately can save operating time 10 to 15 minutes.Each minute acute cerebral stroke patient is all of great value, shortens the success rate that just can increase substantially patient vessel and lead to again for 10 minutes.
the processing method-1 of thrombosis trap setting
Network as Fig. 4 can be designed to plurality of specifications (different-diameter and length) according to clinical needs.According to a certain particular design, first a metal cylinder is processed into and stent diameter mould closely, and on mould, processes many parallel helical grooves according to design.Get one or more to interlock the mode of passing through with forward-reverse spiral line, be wound around along groove and be woven into that near-end is tapered and far-end is columnar network.Support and mould thereof are put into baking oven and carries out thermal finalization.Different materials heat setting process has larger difference.Take memorial alloy as example, heat setting temperature is between 450 degree ~ 550 degree Celsius, and the time is 2 to 30 minutes.Silk material diameter and stent diameter less, shaping time is shorter.After support thermal finalization, get the relevant position that one or more developing ring is fixed to mount proximal end and far-end.Or the silk compact winding developed by x-ray becomes the relevant position to mount proximal end and far-end, be used for showing the near-end of support and remote location.Finally the grid of support most proximal end and delivery guidewire are welded together and be made into thrombosis trap setting finished product.
For the support of Fig. 1, first make the open shape network of Fig. 4 according to above method.Get the silk more tiny than braided support again, by it successively through all grids of this support distalmost end, appropriateness is tightened up this and is fastened silk, thus rack far end is made completely closed or throat structure.Use laser-beam welding machine will fasten a two ends to weld together.Finally produce the thrombosis trap setting finished product of the semi-closed supporting structure of Fig. 1.The reducing of Fig. 1 far-end or closing structure also can be realized by thermal finalization, i.e. the mould far-end of thermal finalization is not cylindrical, but taper or Semen Jujubae shape.
the processing method-2 of thrombosis trap setting
Network as Fig. 4 can be designed to plurality of specifications (different-diameter and length) according to clinical needs.According to a certain particular design, first a metal cylinder is processed into and stent diameter mould closely, and on mould, processes many parallel helical grooves according to design.Get one or more to interlock the mode of passing through with forward-reverse spiral line, be wound around along groove and be woven into that near-end is tapered and far-end is columnar network.Support and mould thereof are put into baking oven and carries out thermal finalization.Different materials heat setting process has larger difference.Take memorial alloy as example, heat setting temperature is between 450 degree ~ 550 degree Celsius, and the time is 2 to 30 minutes.Silk material diameter and stent diameter less, shaping time is shorter.After support thermal finalization, use very sharp cutter according to design by mount proximal end bevel cut.Laser-beam welding machine is adopted to be received on the silk of outer most edge by multiple wire bond scattered again.Get the relevant position that one or more developing ring is fixed to mount proximal end and far-end.Or the silk compact winding developed by x-ray becomes the relevant position to mount proximal end and far-end, be used for showing the near-end of support and remote location.Finally the grid of support most proximal end and delivery guidewire are welded together and be made into thrombosis trap setting finished product.
During the support of construction drawing 1, first open shape network structure as shown in Figure 4 is first produced according to above method, get the silk more tiny than braided support again, by it successively through all grids of support distalmost end, appropriateness is tightened up this and is fastened silk, thus rack far end is made completely closed or throat structure.Use laser-beam welding machine will fasten a two ends to weld together.Finally produce the thrombosis trap setting finished product of the semi-closed supporting structure of Fig. 1.The reducing of Fig. 1 far-end or closing structure also can be realized by thermal finalization, i.e. the mould far-end of thermal finalization is not cylindrical, but taper or Semen Jujubae shape.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvement and distortion, these improve and distortion also should be considered as protection scope of the present invention.
Claims (7)
1. Wicresoft gets involved a thrombosis extraction system, comprises delivery guidewire, microtubular, guiding catheter, the thrombosis trap setting that links together with delivery guidewire far-end, it is characterized in that,
Described thrombosis trap setting is the network woven by individual thread material, described network most proximal end and delivery guidewire weld together, can be separated from weld with described delivery guidewire through electrolysis, described thrombosis trap setting is positioned at the side of the axle that the length direction along delivery guidewire limits, the near-end of support is open, support proximally edge of opening extends to far-end along described axle with cylindrical shape, and the angle that the plane at place, proximal openings edge and described axle are formed is between 0 degree to 75 degree;
The inside diameter ranges of microtubular is 0.2 millimeter to 3 millimeters, and external diametrical extent is 0.5 millimeter to 4 millimeters, and length range is 20 centimetres to 300 centimetres;
Guiding catheter inside diameter ranges is 1 millimeter to 10 millimeters, and external diametrical extent is 2 millimeters to 15 millimeters, and length range is 20 centimetres to 300 centimetres.
2. Wicresoft according to claim 1 gets involved thrombosis extraction system, and it is characterized in that, the silk material diameter range weaving described thrombosis trap setting is 10 microns to 1 millimeter;
The diameter range of the network formed after braiding is 1 millimeter to 30 millimeters;
Rear length range opened by described network is 1 millimeter to 100 millimeters;
It is 20 centimetres to 200 centimetres with the delivery guidewire length that thrombosis trap setting links together.
3. get involved thrombosis extraction system according to the Wicresoft described in claim 1, it is characterized in that, the material of the silk material of described network is:
Nitinol, cochrome, rustless steel, pure platinum or its alloy, true yellow gold or its alloy, pure tantalum or its alloy, pure titanium or its alloy or Biodegradable material;
The material of described delivery guidewire is:
Nitinol, cochrome or rustless steel.
4. Wicresoft according to claim 1 gets involved thrombosis extraction system, it is characterized in that, described guiding catheter far-end has one compared with the soft head of catheter main body softness.
5. Wicresoft according to claim 4 gets involved thrombosis extraction system, and it is characterized in that, the wall thickness range of described soft head is 10 microns to 2 millimeters;
Soft head material is polyurethane, silicone rubber or Pebax;
Soft head hardness range is Shore hardness 25A to 72D.
6. Wicresoft according to claim 1 gets involved thrombosis extraction system, it is characterized in that, described thrombosis trap setting is that sidewall closes or network for having opening, deployable one-tenth one plane.
7. thrombosis trap setting according to claim 1, is characterized in that, the far-end grid of described network fastens into closing structure or throat structure by a silk more tiny than rack body silk material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210268532.4A CN102743209B (en) | 2012-08-01 | 2012-08-01 | Micro-invision intervened thrombus taking system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210268532.4A CN102743209B (en) | 2012-08-01 | 2012-08-01 | Micro-invision intervened thrombus taking system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102743209A CN102743209A (en) | 2012-10-24 |
| CN102743209B true CN102743209B (en) | 2015-04-22 |
Family
ID=47023961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210268532.4A Expired - Fee Related CN102743209B (en) | 2012-08-01 | 2012-08-01 | Micro-invision intervened thrombus taking system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102743209B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104068912A (en) * | 2013-03-26 | 2014-10-01 | 上海微创医疗器械（集团）有限公司 | Intracranial vascular thrombus retrieval machine and thrombus retrieval device |
| CN104068909A (en) * | 2013-03-26 | 2014-10-01 | 上海微创医疗器械（集团）有限公司 | Intracranial vascular thrombus retrieval machine and thrombus retrieval device |
| CN104068910A (en) * | 2013-03-26 | 2014-10-01 | 上海微创医疗器械（集团）有限公司 | Blood vessel thrombus extracting system |
| CN104068952B (en) * | 2014-07-14 | 2015-09-16 | 业聚医疗器械(深圳)有限公司 | The subsidiary conduit carried for guiding endovascular stent |
| CN105125326A (en) * | 2015-08-17 | 2015-12-09 | 魏诗荣 | Intravascular stent of composite structure |
| CN105997314B (en) * | 2016-06-30 | 2018-06-08 | 南京普微森医疗科技有限公司 | A kind of thrombus of complex function eliminates system |
| CN107468306A (en) * | 2017-08-15 | 2017-12-15 | 南京普微森医疗科技有限公司 | A kind of thrombus suction catheter |
| CN107440764B (en) * | 2017-08-16 | 2023-10-27 | 北京赛铂医药科技有限公司 | Conveying device of intravascular distal protector |
| CN107374776B (en) * | 2017-08-16 | 2023-09-12 | 北京赛铂医药科技有限公司 | Cerebral vascular distal protector and laminating method thereof |
| CN107822695A (en) * | 2017-11-22 | 2018-03-23 | 缪中荣 | Special-purpose taking pin device in the cerebrovascular |
| CN115120302B (en) * | 2018-01-30 | 2025-03-18 | 上海沃比医疗科技有限公司 | Thrombus capturing device and method |
| CN109124837A (en) * | 2018-07-06 | 2019-01-04 | 淮阴工学院 | A kind of encephalic of imitative fish scale-shaped takes bolt bracket |
| CN110420046B (en) * | 2019-08-07 | 2020-12-04 | 苏州中天医疗器械科技有限公司 | Minimally invasive interventional thrombus extraction instrument, application and use method thereof |
| CN110974351B (en) * | 2019-12-17 | 2023-03-17 | 禾木（中国）生物工程有限公司 | Curve opening thrombus taking device |
| CN111839806A (en) * | 2020-07-31 | 2020-10-30 | 上海心玮医疗科技有限公司 | High-compliance plug protector and filter screen manufacturing method thereof |
| CN112022426A (en) * | 2020-09-18 | 2020-12-04 | 聚辉医疗科技(深圳)有限公司 | Embolic protection device |
| CN112717260B (en) * | 2020-11-20 | 2022-10-21 | 北京泰杰伟业科技有限公司 | Far-end umbrella protection system |
| CN113616275A (en) * | 2021-07-11 | 2021-11-09 | 辽宁垠艺生物科技股份有限公司 | Device for removing lumen blockage and manufacturing method thereof |
| CN115281784A (en) * | 2022-02-15 | 2022-11-04 | 上海市第六人民医院 | A diseased tissue removal and collection system |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102056554A (en) * | 2008-06-09 | 2011-05-11 | 百乐仕医疗器械有限公司 | Medical treatment tool for tubular organs |
| CN202723926U (en) * | 2012-08-01 | 2013-02-13 | 吕文峰 | Minimally invasive intervention thrombus removing system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007126931A2 (en) * | 2006-03-31 | 2007-11-08 | Ev3 Inc. | Embolic protection devices having radiopaque markers |
| US20070288054A1 (en) * | 2006-06-13 | 2007-12-13 | Tanaka Don A | Vascular thrombectomby apparatus and method of use |
| US8066757B2 (en) * | 2007-10-17 | 2011-11-29 | Mindframe, Inc. | Blood flow restoration and thrombus management methods |
| US20090292307A1 (en) * | 2008-05-22 | 2009-11-26 | Nasser Razack | Mechanical embolectomy device and method |
| DE102010010849B4 (en) * | 2010-03-10 | 2024-10-02 | Acandis Gmbh | Medical device for removing concretions from hollow body organs and method for producing such a device |
| GB2478592B (en) * | 2010-03-12 | 2012-02-29 | Cook Medical Technologies Llc | Obstruction removal assembly and method |
-
2012
- 2012-08-01 CN CN201210268532.4A patent/CN102743209B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102056554A (en) * | 2008-06-09 | 2011-05-11 | 百乐仕医疗器械有限公司 | Medical treatment tool for tubular organs |
| CN202723926U (en) * | 2012-08-01 | 2013-02-13 | 吕文峰 | Minimally invasive intervention thrombus removing system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102743209A (en) | 2012-10-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102743209B (en) | Micro-invision intervened thrombus taking system | |
| CN102764170B (en) | A kind of endovascular stent of complex function | |
| CN107049421B (en) | Full-development thrombus taking support and thrombus taking device | |
| CN106618676B (en) | Intravascular thrombus taking-out device | |
| CN108158630B (en) | Intravascular thrombus catcher | |
| US11179253B2 (en) | Method and apparatus for allowing blood flow through an occluded vessel | |
| CN104000635B (en) | Take bolt device and take pin device | |
| CN202723926U (en) | Minimally invasive intervention thrombus removing system | |
| CN1203811C (en) | Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders | |
| CN105997314B (en) | A kind of thrombus of complex function eliminates system | |
| CN101912323B (en) | Brain aneurysm intravascular stent, manufacture thereof and use method thereof | |
| CN102302377B (en) | Mesh tubular spring for embolism and preparation method thereof | |
| CN105125326A (en) | Intravascular stent of composite structure | |
| CN202724037U (en) | Support and conveying system thereof for treating arterial aneurysm | |
| CN206852642U (en) | A kind of device for taking cerebrovascular thrombus | |
| CN105662533B (en) | Blood vessel thrombus taking device with spiral structure and thrombus therapeutic instrument thereof | |
| CN103547224A (en) | Thrombectomy device | |
| KR20140008315A (en) | Thrombectomy device | |
| US12029441B2 (en) | Thrombectomy device | |
| WO2012081020A1 (en) | Method and apparatus for occlusion retrieval | |
| CN107212913A (en) | A kind of support with thrombus capturing means takes bolt device | |
| CN109223107A (en) | A thrombus removal device | |
| CN111434314A (en) | Can develop thrombectomy support and thrombus remove device of location | |
| CN208876671U (en) | Novel cerebral thrombosis withdrawing device | |
| CN116942255B (en) | Thrombus removing device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170925 Address after: 210061, Jiangsu province Nanjing hi tech Development Zone, Spark Road 10, ding industry, 100 Thai biological building A block 205 room Patentee after: NANJING PUWEISEN MEDICAL TECHNOLOGY CO.,LTD. Address before: 210001 No. 278 Zhonghua Road, Qinhuai District, Jiangsu, Nanjing Co-patentee before: Zhang Cuixin Patentee before: Lv Wenfeng Co-patentee before: Wei Shirong |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180601 Address after: 450016 Henan Zhengzhou Economic Development Zone, Zhengzhou five South Road Seventh People's hospital 4 Building 2 unit 501 Patentee after: Lv Wenfeng Address before: 210061 room 205, block A, Ting Tai bio tech building, 10 Spark Road, Nanjing hi tech Development Zone, Jiangsu. Patentee before: NANJING PUWEISEN MEDICAL TECHNOLOGY CO.,LTD. |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150422 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |