CN102697835A - External medicament for treating skin diseases - Google Patents
External medicament for treating skin diseases Download PDFInfo
- Publication number
- CN102697835A CN102697835A CN2012102346823A CN201210234682A CN102697835A CN 102697835 A CN102697835 A CN 102697835A CN 2012102346823 A CN2012102346823 A CN 2012102346823A CN 201210234682 A CN201210234682 A CN 201210234682A CN 102697835 A CN102697835 A CN 102697835A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- weight
- weight portions
- portions
- cinnabaris
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 93
- 208000017520 skin disease Diseases 0.000 title claims abstract description 14
- 206010000496 acne Diseases 0.000 claims abstract description 79
- 229940079593 drug Drugs 0.000 claims abstract description 64
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 49
- 239000004863 Frankincense Substances 0.000 claims abstract description 48
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 45
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 239000003860 topical agent Substances 0.000 claims description 102
- 241000717739 Boswellia sacra Species 0.000 claims description 47
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 47
- RSWGJHLUYNHPMX-ONCXSQPRSA-N abietic acid Chemical compound C([C@@H]12)CC(C(C)C)=CC1=CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(O)=O RSWGJHLUYNHPMX-ONCXSQPRSA-N 0.000 claims description 45
- 239000010238 camphora Substances 0.000 claims description 44
- 229940025250 camphora Drugs 0.000 claims description 44
- 238000005242 forging Methods 0.000 claims description 44
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 43
- 244000293323 Cosmos caudatus Species 0.000 claims description 43
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 43
- 241001057584 Myrrha Species 0.000 claims description 43
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 claims description 40
- 239000012567 medical material Substances 0.000 claims description 35
- 229940099259 vaseline Drugs 0.000 claims description 30
- 239000011505 plaster Substances 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 239000002674 ointment Substances 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 19
- 239000000843 powder Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 11
- 206010048768 Dermatosis Diseases 0.000 claims description 10
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000007766 cera flava Substances 0.000 claims description 5
- 239000000499 gel Substances 0.000 claims description 5
- 239000000865 liniment Substances 0.000 claims description 5
- 229940040145 liniment Drugs 0.000 claims description 5
- 239000006210 lotion Substances 0.000 claims description 5
- 239000006072 paste Substances 0.000 claims description 5
- -1 patch Substances 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 239000002966 varnish Substances 0.000 claims description 5
- 244000043261 Hevea brasiliensis Species 0.000 claims description 4
- 229940057995 liquid paraffin Drugs 0.000 claims description 4
- 229920003052 natural elastomer Polymers 0.000 claims description 4
- 229920001194 natural rubber Polymers 0.000 claims description 4
- 239000012188 paraffin wax Substances 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical compound CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000004137 mechanical activation Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229940126680 traditional chinese medicines Drugs 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims 1
- 208000020154 Acnes Diseases 0.000 abstract description 3
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 abstract 1
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 1
- 240000007551 Boswellia serrata Species 0.000 abstract 1
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 1
- 241000723346 Cinnamomum camphora Species 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- 229940105847 calamine Drugs 0.000 abstract 1
- 229930008380 camphor Natural products 0.000 abstract 1
- 229960000846 camphor Drugs 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 229910052956 cinnabar Inorganic materials 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 239000010440 gypsum Substances 0.000 abstract 1
- 229910052602 gypsum Inorganic materials 0.000 abstract 1
- 229910052864 hemimorphite Inorganic materials 0.000 abstract 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 abstract 1
- 235000014692 zinc oxide Nutrition 0.000 abstract 1
- 239000011787 zinc oxide Substances 0.000 abstract 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 37
- 238000012360 testing method Methods 0.000 description 20
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 210000003780 hair follicle Anatomy 0.000 description 9
- 230000028327 secretion Effects 0.000 description 9
- 206010040943 Skin Ulcer Diseases 0.000 description 8
- 230000037396 body weight Effects 0.000 description 8
- 231100000019 skin ulcer Toxicity 0.000 description 8
- 210000002374 sebum Anatomy 0.000 description 7
- 208000025865 Ulcer Diseases 0.000 description 6
- 210000001732 sebaceous gland Anatomy 0.000 description 6
- 231100000397 ulcer Toxicity 0.000 description 6
- 230000003325 follicular Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 241000700199 Cavia porcellus Species 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 241000186427 Cutibacterium acnes Species 0.000 description 3
- 206010037888 Rash pustular Diseases 0.000 description 3
- 239000003098 androgen Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 208000029561 pustule Diseases 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 241000191963 Staphylococcus epidermidis Species 0.000 description 2
- 208000033809 Suppuration Diseases 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000000589 cicatrix Anatomy 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 210000001061 forehead Anatomy 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000003780 keratinization Effects 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 206010040882 skin lesion Diseases 0.000 description 2
- 231100000444 skin lesion Toxicity 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241001070941 Castanea Species 0.000 description 1
- 235000014036 Castanea Nutrition 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 241000193880 Demodex folliculorum Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010061926 Purulence Diseases 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 239000008738 huangbai Substances 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229940039412 ketalar Drugs 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 230000024241 parasitism Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- 210000003859 smegma Anatomy 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to an external medicament for treating skin diseases, and in particular relates to an external medicament. The medicament comprises the following drugs and medicinal matrixes or prepared from the following drugs and medicinal matrixes: cinnabar, calamine, borneol, frankincense, myrrh, rosin, castor oil, gypsum (sintered), camphor, calculus bovis factitius and pearl. The invention also relates to application of medicinal composition of the external medicament and a preparation method of the external medicament. The external medicament can be effectively used for treating skin diseases, such as whelk, pimples and acnes.
Description
Technical field
The present invention relates to medical technical field, relate to a kind of topical agent of treating dermatosis, the topical agent of particularly a kind of treatment comedo, skin sore, acne.Specifically, this topical agent can be applied to fire-toxin and stop up Sheng, the furuncle sore, and red and swollen heat pain, pus are not held back person etc. after becoming routed and stain, skin skin ulcer class diseases such as especially suitable comedo, skin sore, acne.The invention still further relates to the method for preparing of this topical agent.
Background technology
Acne is commonly called as " comedo ", is " pimples ", " acne ", " whelk ", " skin sore " etc. again, is modal pilosebaceous chronic inflammatory disease dermatoses.Because of the obstruction of sebaceous gland duct and pore, due to the sebum outflow is not smooth.After adolescence, almost everyone can on the face or other positions gave birth to acne, just some people's quantity is few, the time is short, generally at 25 years old later on naturally trend fully recover, so needn't be present to the mind; Somebody's quantity is many, shows as pimple, blackhead, pustule, abscess, tuberosity, cyst, even cicatrix, often hinders attractive in appearance.The somebody seeks medical advice or own random controlling carelessly, so that sb.'s illness took a turn for the worse, produces more cicatrix, regrets to the very end of one's life.
Acne is a kind of multifactor disease that causes; Having under the condition of inherited genetic factors, the action of microorganisms such as corynebacterium acnes that androgen secretion increases in (especially the dihydrotestosterone in the skin histology is increased) and the follicular orifice are two principal elements of acne morbidity.The growth of human body sebaceous gland and sebum secretion directly receive the domination of androgen, and adolescence stimulates sebaceous gland because the androgen level significantly improves; Make the sebum secretion dysfunction active, sebum is secreted in a large number, makes skin glossy shinny; Follicular orifice also enlarges thereupon, because the keratinization of pilosebaceous duct or follicular orifice is stopped up, too much sebum can not in time be discharged; The stasis of blood is amassed and in hair follicle, is formed fat bolt, promptly so-called acne.The fat dissolving enzyme that corynebacterium acnes produced, protease and hyaluronidase can decompose the triglyceride in the sebum; Become free fatty; It can destroy follicular wall; The hair follicle inclusions is got into and stimulation corium and hair follicle surrounding tissue, cause pilosebaceous unit inflammatory reaction on every side, cause a series of acne symptoms.Part pustule is because the secondary infection of demodex folliculorum parasitism or Staphylococcus albus.
Comedo (acne, acne) pilosity is born among the crowd of adolescence or oily skin.There are buccal, lower jaw and forehead in the good position of sending out, also is shown in shirtfront or back.What have is grain of rice shape, and what have is pustule appearance, and outbreak repeatedly is difficult to cure.Especially long acne at face has not only had a strong impact on attractive in appearancely, and has caused pressure mentally for adolescence, produces the psychology of feeling oneself inferior, even directly influences work, studying and living.
Modern medicine thinks that the genesis mechanism of acne and reason mainly contain the following aspects: 1, the adolescence hormone secretion is too much, and sebum secretion is hyperfunction, produces excessive oils and fats, fatty acid; Cause sebaceous gland not smooth; Hair follicle tube wall keratinization material increases and blocks the hair follicle hole, causes inflammation, and forms acne.2, the hair follicle obstruction makes the breeding (mainly being corynebacterium acnes or Staphylococcus albus) in a large number under anaerobic condition of partial antibacterial, causes suppurative folliculitis, i.e. comedo (acne, acne).3, because of individual inheritance's effect of factors, how much relevant sebaceous gland size, quantity and secretion be.The food of edible higher fatty acid or pungent stimulation has certain influence to the secretion of skin sebaceous gland, makes the hair follicle secretion not smooth, forms comedo (acne, acne).4, medicine also can cause comedo (acne, acne), like hormones or VAD.5, adolescence women's menstrual cycle, variation has taken place in the hormone in vivo level, and the smegma disorder can make comedo (acne, acne) increase the weight of.6, due to the extraneous factor, contain lanoline or vaseline is the cosmetics of raw material, block the normal drainage of hair follicle like life-time service; Dust in air, harmful substance stick to does not in time remove cleaning on the skin, block hair follicle and form comedo (acne, acne).
At present, it is various in style to be used to treat dermopathic external chemical medicine class plaster such as comedo, skin sore, acne, but chemical medicine because of drawbacks limit such as curative effect and toxic and side effects its use clinically.Chinese medicine plaster has unique clinical efficacy and lower toxic and side effects, receives doctor and patient's favor deeply.But the Chinese medicine plaster preparation that can really be applied to clinical treatment at present is very deficient, and is mostly the prescription that spreads, the lack of scientific demonstration, and curative effect is also imprecise, causes the state of an illness to incur loss through delay easily.
Therefore, to need effectively to treat with comedo, skin sore, acne etc. be that the dermopathic medicine of representative is used for clinical in this area.
Summary of the invention
The objective of the invention is to the problems referred to above, for clinical a kind of novelty is provided be used to that to treat with comedo, skin sore, acne etc. be the dermopathic topical agent of representative.The inventor finds that a kind of topical agent that comprises component preparations such as Cinnabaris, Calamina, Borneolum Syntheticum has evident in efficacy, cheap, safe advantage for above-mentioned dermatosis.
For this reason, the purpose of first aspect present invention provides that a kind of can be effective to treat and/or prevent with comedo, skin sore, acne etc. be the dermopathic topical agent of representative.The purpose of second aspect of the present invention provides the method for the above-mentioned topical agent of preparation.The purpose of third aspect present invention provides above-mentioned a kind of Chinese medicine composition and is used for treating the for example purposes of the topical agent of comedo, skin sore, acne of dermatosis in preparation.
Particularly, first aspect present invention provides a kind of topical agent, and this topical agent can be used for treating and/or preventing dermatosis for example comedo, skin sore, acne etc.Particularly; First aspect present invention provides a kind of topical agent; It comprises ten medical material and drug matrices simply of following component, perhaps its by comprise following component ten simply medical material and drug matrices process: Cinnabaris, Calamina, Borneolum Syntheticum, Olibanum, Myrrha, Colophonium, Oleum Ricini, Gypsum Fibrosum (forging), Camphora, artificial Calculus Bovis, Margarita.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and the Calamina amount is the 20-160 weight portion; 30-120 weight portion for example; 40-100 weight portion for example, 50-80 weight portion for example, for example about 50 weight portions, about 63 weight portions or about 78 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and the Borneolum Syntheticum amount is the 25-125 weight portion; 50-100 weight portion for example; 60-80 weight portion for example, 65-75 weight portion for example, for example about 66 weight portions, about 70 weight portions or about 74 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and the Olibanum amount is the 10-80 weight portion; 15-60 weight portion for example; 20-50 weight portion for example, 20-35 weight portion for example, for example about 21 weight portions, about 25 weight portions or about 33 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and not having dose is the 10-75 weight portion; 20-50 weight portion for example; 25-40 weight portion for example, 25-35 weight portion for example, for example about 28 weight portions, about 30 weight portions or about 32 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and the Colophonium amount is the 50-160 weight portion; 70-140 weight portion for example; 80-125 weight portion for example, 85-110 weight portion for example, for example about 84 weight portions, about 90 weight portions or about 110 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and the Semen Ricini oil mass is the 20-90 weight portion; 30-75 weight portion for example; 35-60 weight portion for example, 40-45 weight portion for example, for example about 40 weight portions, about 42 weight portions or about 44 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and Gypsum Fibrosum (forging) amount is the 10-80 weight portion; 15-50 weight portion for example; 25-40 weight portion for example, 25-35 weight portion for example, for example about 26 weight portions, about 30 weight portions or about 31 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and the Camphora amount is the 20-120 weight portion; 30-100 weight portion for example; 40-90 weight portion for example, 50-75 weight portion for example, for example about 50 weight portions, about 66 weight portions or about 74 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and artificial Calculus Bovis's amount is the 0.5-10 weight portion; 1-5 weight portion for example; 1.25-4 weight portion for example, 1.5-3.5 weight portion for example, for example about 1.5 weight portions, about 2.1 weight portions or about 3.3 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and the Margarita amount is the 0.5-10 weight portion; 1-5 weight portion for example; 1.5-4 weight portion for example, 2-3 weight portion for example, for example about 2 weight portions, about 2.5 weight portions or about 2.7 weight portions.
According to the topical agent of first aspect present invention, Cinnabaris is in 200 weight portions in its medical material, and the drug matrices amount is the 200-850 weight portion, for example 300-750 weight portion, for example 400-650 weight portion, for example 450-600 weight portion.
According to the topical agent of first aspect present invention, wherein said drug matrices is an oleaginous base.In one embodiment, said drug matrices is selected from following one or more: lanoline, vaseline, paraffin, Cera Flava, tristearin, natural rubber, liquid paraffin.
Topical agent according to first aspect present invention; Comprise lanoline in the wherein said drug matrices, Cinnabaris is in 200 weight portions in its medical material, and the lanoline amount is the 5-50 weight portion; 7.5-40 weight portion for example; 10-30 weight portion for example, 15-25 weight portion for example, for example about 16 weight portions, about 17 weight portions or about 22 weight portions.Topical agent according to first aspect present invention; Comprise vaseline in the wherein said drug matrices, Cinnabaris is in 200 weight portions in its medical material, and the vaseline amount is the 200-800 weight portion; 300-700 weight portion for example; 400-600 weight portion for example, 425-550 weight portion for example, for example about 420 weight portions, about 480 weight portions or about 540 weight portions.
According to the topical agent of first aspect present invention, comprising:
| Cinnabaris | 200 weight portions, |
| Calamina | The 20-160 weight portion, |
| Borneolum Syntheticum | The 25-125 weight portion, |
| Olibanum | The 10-80 weight portion, |
| Myrrha | The 10-75 weight portion, |
| Colophonium | The 50-160 weight portion, |
| Oleum Ricini | The 20-90 weight portion, |
| Gypsum Fibrosum (forging) | The 10-80 weight portion, |
| Camphora | The 20-120 weight portion, |
| The artificial Calculus Bovis | 0.5-10 weight portion, |
| Margarita | 0.5-10 weight portion, |
| Drug matrices | The 200-850 weight portion. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabaris | 200 weight portions, |
| Calamina | The 30-120 weight portion, |
| Borneolum Syntheticum | The 50-100 weight portion, |
| Olibanum | The 15-60 weight portion, |
| Myrrha | The 20-50 weight portion, |
| Colophonium | The 70-140 weight portion, |
| Oleum Ricini | The 30-75 weight portion, |
| Gypsum Fibrosum (forging) | The 15-50 weight portion, |
| Camphora | The 30-100 weight portion, |
| The artificial Calculus Bovis | The 1-5 weight portion, |
| Margarita | The 1-5 weight portion, |
| Drug matrices | The 300-750 weight portion. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabaris | 200 weight portions, |
| Calamina | The 40-100 weight portion, |
| Borneolum Syntheticum | The 60-80 weight portion, |
| Olibanum | The 20-50 weight portion, |
| Myrrha | The 25-40 weight portion, |
| Colophonium | The 80-125 weight portion, |
| Oleum Ricini | The 35-60 weight portion, |
| Gypsum Fibrosum (forging) | The 25-40 weight portion, |
| Camphora | The 40-90 weight portion, |
| The artificial Calculus Bovis | 1.25-4 weight portion, |
| Margarita | 1.5-4 weight portion, |
| Drug matrices | The 400-650 weight portion. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabaris | 200 weight portions, |
| Calamina | The 50-80 weight portion, |
| Borneolum Syntheticum | The 65-75 weight portion, |
| Olibanum | The 20-35 weight portion, |
| Myrrha | The 25-35 weight portion, |
| Colophonium | The 85-110 weight portion, |
| Oleum Ricini | The 40-45 weight portion, |
| Gypsum Fibrosum (forging) | The 25-35 weight portion, |
| Camphora | The 50-75 weight portion, |
| The artificial Calculus Bovis | 1.5-3.5 weight portion, |
| Margarita | The 2-3 weight portion, |
| Drug matrices | The 450-600 weight portion. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabaris | 180 weight portions, |
| Calamina | 70 weight portions, |
| Borneolum Syntheticum | 60 weight portions, |
| Olibanum | 30 weight portions, |
| Myrrha | 25 weight portions, |
| Colophonium | 100 weight portions, |
| Oleum Ricini | 40 weight portions, |
| Gypsum Fibrosum (forging) | 28 weight portions, |
| Camphora | 60 weight portions, |
| The artificial Calculus Bovis | 3 weight portions, |
| Margarita | 2.4 weight portion, |
| Lanoline | 20 weight portions, |
| Vaseline | 490 weight portions. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabaris | 190 weight portions, |
| Calamina | 60 weight portions, |
| Borneolum Syntheticum | 70 weight portions, |
| Olibanum | 20 weight portions, |
| Myrrha | 30 weight portions, |
| Colophonium | 80 weight portions, |
| Oleum Ricini | 40 weight portions, |
| Gypsum Fibrosum (forging) | 25 weight portions, |
| Camphora | 70 weight portions, |
| The artificial Calculus Bovis | 2.0 weight portion, |
| Margarita | 2.4 weight portion, |
| Lanoline | 15 weight portions, |
| Vaseline | 460 weight portions. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabaris | 200 weight portions, |
| Calamina | 50 weight portions, |
| Borneolum Syntheticum | 70 weight portions, |
| Olibanum | 25 weight portions, |
| Myrrha | 30 weight portions, |
| Colophonium | 90 weight portions, |
| Oleum Ricini | 40 weight portions, |
| Gypsum Fibrosum (forging) | 30 weight portions, |
| Camphora | 50 weight portions, |
| The artificial Calculus Bovis | 1.5 weight portion, |
| Margarita | 2.0 weight portion, |
| Lanoline | 17 weight portions, |
| Vaseline | 420 weight portions. |
According to the topical agent of first aspect present invention, wherein said each medical material is that the method through physical treatment joins in the said topical agent.
According to the topical agent of first aspect present invention, wherein said each medical material is to join in the said topical agent through the method that physical pulverization is handled.In one embodiment, said physical pulverization can be to be selected from following mode: water flies, mechanical activation comminution, grinding and combination thereof.
According to the topical agent of first aspect present invention, it is to be to be selected from following medicine type: plaster, ointment, plaster, ointment, paste, lotion, varnish, patch, gel, liniment, spray, emplastrum.
According to the topical agent of first aspect present invention, comprising the crude drug total amount among its every 1000g is 100-900g, 200-800g for example, 300-700g for example, 400-700g for example, 500-700g for example, for example about 500g, 600g for example, for example about 700g.
According to the compositions of first aspect present invention, it is the medicament of ointment.
According to the topical agent of first aspect present invention, it is the medicament of plaster.In one embodiment, said plaster is to be applied to mount on the backing material by the topical agent of first aspect present invention stand to process, and it is the external preparation that can supply skin to stick.
Second aspect present invention provides the preparation that is combined in of following traditional Chinese medicines material to be used for treating and/or preventing the for example purposes of the topical agent of diseases such as comedo, skin sore, acne of dermatosis: Cinnabaris, Calamina, Borneolum Syntheticum, Olibanum, Myrrha, Colophonium, Oleum Ricini, Gypsum Fibrosum (forging), Camphora, artificial Calculus Bovis, Margarita.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and the Calamina amount is the 20-160 weight portion; 30-120 weight portion for example; 40-100 weight portion for example, 50-80 weight portion for example, for example about 50 weight portions, about 63 weight portions or about 78 weight portions.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and the Borneolum Syntheticum amount is the 25-125 weight portion; 50-100 weight portion for example; 60-80 weight portion for example, 65-75 weight portion for example, for example about 66 weight portions, about 70 weight portions or about 74 weight portions.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and the Olibanum amount is the 10-80 weight portion; 15-60 weight portion for example; 20-50 weight portion for example, 20-35 weight portion for example, for example about 21 weight portions, about 25 weight portions or about 33 weight portions.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and not having dose is the 10-75 weight portion; 20-50 weight portion for example; 25-40 weight portion for example, 25-35 weight portion for example, for example about 28 weight portions, about 30 weight portions or about 32 weight portions.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and the Colophonium amount is the 50-160 weight portion; 70-140 weight portion for example; 80-125 weight portion for example, 85-110 weight portion for example, for example about 84 weight portions, about 90 weight portions or about 110 weight portions.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and the Semen Ricini oil mass is the 20-90 weight portion; 30-75 weight portion for example; 35-60 weight portion for example, 40-45 weight portion for example, for example about 40 weight portions, about 42 weight portions or about 44 weight portions.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and Gypsum Fibrosum (forging) amount is the 10-80 weight portion; 15-50 weight portion for example; 25-40 weight portion for example, 25-35 weight portion for example, for example about 26 weight portions, about 30 weight portions or about 31 weight portions.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and the Camphora amount is the 20-120 weight portion; 30-100 weight portion for example; 40-90 weight portion for example, 50-75 weight portion for example, for example about 50 weight portions, about 66 weight portions or about 74 weight portions.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and artificial Calculus Bovis's amount is the 0.5-10 weight portion; 1-5 weight portion for example; 1.25-4 weight portion for example, 1.5-3.5 weight portion for example, for example about 1.5 weight portions, about 2.1 weight portions or about 3.3 weight portions.
According to the purposes of second aspect present invention, Cinnabaris is in 200 weight portions in the said Chinese crude drug, and the Margarita amount is the 0.5-10 weight portion; 1-5 weight portion for example; 1.5-4 weight portion for example, 2-3 weight portion for example, for example about 2 weight portions, about 2.5 weight portions or about 2.7 weight portions.
According to the purposes of second aspect present invention, also comprise drug matrices in the said topical agent.Cinnabaris is in 200 weight portions in the medical material of said topical agent, and the drug matrices amount is the 200-850 weight portion, for example 300-750 weight portion, for example 400-650 weight portion, for example 450-600 weight portion.According to the purposes of second aspect present invention, wherein said drug matrices is an oleaginous base.In one embodiment, said drug matrices is selected from following one or more: lanoline, vaseline, paraffin, Cera Flava, tristearin, natural rubber, liquid paraffin.
Purposes according to second aspect present invention; Comprise lanoline in the said drug matrices of said topical agent, Cinnabaris is in 200 weight portions in the medical material, and the lanoline amount is the 5-50 weight portion; 7.5-40 weight portion for example; 10-30 weight portion for example, 15-25 weight portion for example, for example about 16 weight portions, about 17 weight portions or about 22 weight portions.Purposes according to second aspect present invention; Comprise vaseline in the said drug matrices of said topical agent, Cinnabaris is in 200 weight portions in the medical material, and the vaseline amount is the 200-800 weight portion; 300-700 weight portion for example; 400-600 weight portion for example, 425-550 weight portion for example, for example about 420 weight portions, about 480 weight portions or about 540 weight portions.
According to the purposes of second aspect present invention, comprise in the said topical agent:
| Cinnabaris | 200 weight portions, |
| Calamina | The 20-160 weight portion, |
| Borneolum Syntheticum | The 25-125 weight portion, |
| Olibanum | The 10-80 weight portion, |
| Myrrha | The 10-75 weight portion, |
| Colophonium | The 50-160 weight portion, |
| Oleum Ricini | The 20-90 weight portion, |
| Gypsum Fibrosum (forging) | The 10-80 weight portion, |
| Camphora | The 20-120 weight portion, |
| The artificial Calculus Bovis | 0.5-10 weight portion, |
| Margarita | 0.5-10 weight portion, |
| Drug matrices | The 200-850 weight portion. |
According to the purposes of second aspect present invention, comprise in the said topical agent:
| Cinnabaris | 200 weight portions, |
| Calamina | The 30-120 weight portion, |
| Borneolum Syntheticum | The 50-100 weight portion, |
| Olibanum | The 15-60 weight portion, |
| Myrrha | The 20-50 weight portion, |
| Colophonium | The 70-140 weight portion, |
| Oleum Ricini | The 30-75 weight portion, |
| Gypsum Fibrosum (forging) | The 15-50 weight portion, |
| Camphora | The 30-100 weight portion, |
| The artificial Calculus Bovis | The 1-5 weight portion, |
| Margarita | The 1-5 weight portion, |
| Drug matrices | The 300-750 weight portion. |
According to the purposes of second aspect present invention, comprise in the said topical agent:
| Cinnabaris | 200 weight portions, |
| Calamina | The 40-100 weight portion, |
| Borneolum Syntheticum | The 60-80 weight portion, |
| Olibanum | The 20-50 weight portion, |
| Myrrha | The 25-40 weight portion, |
| Colophonium | The 80-125 weight portion, |
| Oleum Ricini | The 35-60 weight portion, |
| Gypsum Fibrosum (forging) | The 25-40 weight portion, |
| Camphora | The 40-90 weight portion, |
| The artificial Calculus Bovis | 1.25-4 weight portion, |
| Margarita | 1.5-4 weight portion, |
| Drug matrices | The 400-650 weight portion. |
According to the purposes of second aspect present invention, comprise in the said topical agent:
| Cinnabaris | 200 weight portions, |
| Calamina | The 50-80 weight portion, |
| Borneolum Syntheticum | The 65-75 weight portion, |
| Olibanum | The 20-35 weight portion, |
| Myrrha | The 25-35 weight portion, |
| Colophonium | The 85-110 weight portion, |
| Oleum Ricini | The 40-45 weight portion, |
| Gypsum Fibrosum (forging) | The 25-35 weight portion, |
| Camphora | The 50-75 weight portion, |
| The artificial Calculus Bovis | 1.5-3.5 weight portion, |
| Margarita | The 2-3 weight portion, |
| Drug matrices | The 450-600 weight portion. |
According to the purposes of second aspect present invention, comprise in the said topical agent:
| Cinnabaris | 180 weight portions, |
| Calamina | 70 weight portions, |
| Borneolum Syntheticum | 60 weight portions, |
| Olibanum | 30 weight portions, |
| Myrrha | 25 weight portions, |
| Colophonium | 100 weight portions, |
| Oleum Ricini | 40 weight portions, |
| Gypsum Fibrosum (forging) | 28 weight portions, |
| Camphora | 60 weight portions, |
| The artificial Calculus Bovis | 3 weight portions, |
| Margarita | 2.4 weight portion, |
| Lanoline | 20 weight portions, |
| Vaseline | 490 weight portions. |
According to the purposes of second aspect present invention, comprise in the said topical agent:
| Cinnabaris | 190 weight portions, |
| Calamina | 60 weight portions, |
| Borneolum Syntheticum | 70 weight portions, |
| Olibanum | 20 weight portions, |
| Myrrha | 30 weight portions, |
| Colophonium | 80 weight portions, |
| Oleum Ricini | 40 weight portions, |
| Gypsum Fibrosum (forging) | 25 weight portions, |
| Camphora | 70 weight portions, |
| The artificial Calculus Bovis | 2.0 weight portion, |
| Margarita | 2.4 weight portion, |
| Lanoline | 15 weight portions, |
| Vaseline | 460 weight portions. |
According to the purposes of second aspect present invention, comprise in the said topical agent:
| Cinnabaris | 200 weight portions, |
| Calamina | 50 weight portions, |
| Borneolum Syntheticum | 70 weight portions, |
| Olibanum | 25 weight portions, |
| Myrrha | 30 weight portions, |
| Colophonium | 90 weight portions, |
| Oleum Ricini | 40 weight portions, |
| Gypsum Fibrosum (forging) | 30 weight portions, |
| Camphora | 50 weight portions, |
| The artificial Calculus Bovis | 1.5 weight portion, |
| Margarita | 2.0 weight portion, |
| Lanoline | 25 weight portions, |
| Vaseline | 412 weight portions. |
According to the purposes of second aspect present invention, each medical material is that method through physical treatment joins in the said compositions in the said topical agent.
According to the purposes of second aspect present invention, each medical material is to join in the said compositions through the method that physical pulverization is handled in the said topical agent.In one embodiment, said physical pulverization can be to be selected from following mode: water flies, mechanical activation comminution, grinding and combination thereof.
According to the purposes of second aspect present invention, said topical agent is to be to be selected from following medicine type: plaster, ointment, plaster, ointment, paste, lotion, varnish, patch, gel, liniment, spray, emplastrum.
According to the purposes of second aspect present invention, comprising the crude drug total amount among the every 1000g of said topical agent is 100-900g, 200-800g for example, 300-700g for example, 400-700g for example, 500-700g for example, for example about 500g, 600g for example, for example about 700g.
According to the purposes of second aspect present invention, wherein said product is the medicament of ointment.
According to the purposes of second aspect present invention, wherein said topical agent is the medicament of plaster.In one embodiment; Said plaster is to be applied to mount on the backing material by the material stand that medical material combination and the drug matrices of Cinnabaris, Calamina, Borneolum Syntheticum, Olibanum, Myrrha, Colophonium, Oleum Ricini, Gypsum Fibrosum (forging), Camphora, artificial Calculus Bovis, Margarita are processed to process, and it is the external preparation that can supply skin to stick.
Third aspect present invention provides the method for preparing each said topical agent of first aspect present invention, and it may further comprise the steps:
A, Cinnabaris water is flown into impalpable powder;
B, Margarita, Olibanum, Myrrha are ground into fine powder;
C, Gypsum Fibrosum (forging) is ground into fine powder, crosses 150 mesh sieves;
D, with Camphora, artificial Calculus Bovis, Borneolum Syntheticum and Calamina facing-up, cross 160 mesh sieves;
E, get Oleum Ricini in addition and endure to dripping into pearl, cold slightly, add Margarita, Olibanum, Myrrha and particulate Colophonium, stir and make complete molten; Add drug matrices (such as but not limited to lanoline and vaseline) again, make fusing fully, filter through 120 mesh sieves;
F, adding Gypsum Fibrosum fine powder stir, and are chilled to below 40 ℃;
G, camphorate, artificial Calculus Bovis, Borneolum Syntheticum, grind well;
H, adding Cinnabaris fine powder, mixing promptly gets.
According to the method for third aspect present invention, it also further comprises processes the step that is selected from following medicine type with said topical agent: plaster, ointment, plaster, ointment, paste, lotion, varnish, patch, gel, liniment, spray, emplastrum.
According to the method for third aspect present invention, it also further comprises the step of said topical agent being processed plaster.
According to the method for third aspect present invention, it also further comprises said topical agent stand is applied to mounts the step of processing plaster on the backing material.
Arbitrary technical characterictic that arbitrary embodiment had of the arbitrary aspect of the present invention or this arbitrary aspect is suitable for arbitrary embodiment of other arbitrary embodiment or other arbitrary aspect equally; As long as they can be not conflicting; Certainly at where applicable each other, necessary words can be done suitably to modify to individual features.Do further to describe with characteristics to various aspects of the present invention below.
All documents that the present invention quoted from, their full content is incorporated this paper by reference into, and if the expressed implication of these documents and the present invention when inconsistent, be as the criterion with statement of the present invention.In addition; Various terms and phrase that the present invention uses have the general sense of well known to a person skilled in the art; Nonetheless; The present invention still hopes at this more detailed explanation and explanation to be done in these terms and phrase, and term of mentioning and phrase are as the criterion with the implication that the present invention was explained if any inconsistent with known implication.
In the present invention, can use the topical agent of the present invention (also can be described as compositions) of effective dose to be applied to have need receive examination individual.As described herein, term " effective dose " is meant the purpose dosage that can in the experimenter, realize preventing and/or treating situation according to the invention, obstacle, disease or disease.Those skilled in the art are context according to the present invention, can easily confirm the using dosage of topical agent of the present invention.Especially, according to the present invention, term " effective dose " is appreciated that to topical agent of the present invention with reasonable effect/risk of being applicable to any therapeutic treatment and/or prevention than the q.s that treats and/or prevents said situation, obstacle, disease or disease.But the total consumption per day that it should be understood that topical agent of the present invention can maked decision in the medical judgment scope by those skilled in the art reliably.For any concrete experimenter, the horizontal fibrous root of concrete prevention effective dose is decided according to multiple factor, and said factor comprises experimenter's age, body weight, general health situation, sex and diet; The concrete topical agent that is adopted; Make up other therapeutic active substance of using or using simultaneously with topical agent of the present invention; And the known similar factor of medical field.With regard to the present invention, general daily dose scope is torn open and is counted as the medical material meter, can be 0.1 ~ 100g/kg body weight; For example 0.2 ~ 50g/kg body weight, for example 0.2 ~ 25g/kg body weight, for example 0.5 ~ 50g/kg body weight; For example 0.5 ~ 25g/kg body weight, for example 1 ~ 20g/kg body weight, for example 2 ~ 10g/kg body weight.
Generally speaking product provided by the invention can use through the mode that external is smeared, and with regard to use amount, normally is accustomed to consumption with people and uses; For example for the related disease of the present invention, the treatment of disease sites partial smearing use in right amount also can, for example every square centimeter of skin can use 0.1g ~ 1g; For example 0.1g ~ 0.5g, for example 0.1g ~ 0.4g, for example 0.1g ~ 0.3g; For example 0.2g ~ 0.5g, for example 0.3g ~ 0.5g.
In the present invention; It comprises Cinnabaris, Calamina, Olibanum, Myrrha, Colophonium, Oleum Ricini, Gypsum Fibrosum (forging), Margarita when mentioning " raw medicinal herbs " or " crude drug "; And (, being appreciated that to raw medicinal herbs or crude drug) Borneolum Syntheticum, Camphora, artificial Calculus Bovis if exist.
Topical agent provided by the invention can be used to treat and/or prevent dermatosis, and said dermatosis is such as but not limited to diseases such as comedo, skin sore, acne, pimples, acne, whelks.
The inventor has found to have the Chinese prescription of heat-clearing and toxic substances removing granulation promoting, promoting blood circulation and detumescence through creative work, and this Chinese prescription is evident in efficacy to the treatment of dermatosis according to the invention, have no side effect.
The present invention compares with existing technology, has the following advantages and clinical effectiveness: the present invention selects pure raw material of Chinese medicine for use, is easy to industrialization production.In addition, topical agent of the present invention has effects such as erosion prevention and muscle growing, heat-clearing and toxic substances removing, uses proof through clinical practice for many years, is used to treat skin skin ulcer class diseases such as comedo, skin sore, acne, and total effective rate reaches more than 95%, and does not find to have other toxic and side effects.
The specific embodiment
Further specify the present invention through concrete embodiment/experimental example below, still, be to be understood that into, these embodiment and experimental example are only used for the usefulness of explanation more in detail particularly, are used for limiting in any form the present invention and should not be construed as.
The present invention carries out generality and/or concrete description to the material and the test method that are used in the test.Though for realizing that employed many materials of the object of the invention and operational approach are well known in the art, the present invention still does to describe in detail as far as possible at this.It will be apparent to those skilled in the art that hereinafter, if do not specify that material therefor of the present invention and operational approach are well known in the art.
A, preparation embodiment part
Embodiment 1,2,3: prepare topical agent of the present invention
The formula ratio of the embodiment of the invention 1,2,3 topical agents is (weight portion is with the preparation in batches of 5000 grams) as follows:
| Form | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Cinnabaris | 180 | 190 | 200 |
| Calamina | 70 | 60 | 50 |
| Borneolum Syntheticum | 60 | 70 | 70 |
| Olibanum | 30 | 20 | 25 |
| Myrrha | 25 | 30 | 30 |
| Colophonium | 100 | 80 | 90 |
| Oleum Ricini | 40 | 40 | 40 |
| Gypsum Fibrosum (forging) | 28 | 25 | 30 |
| Camphora | 60 | 70 | 50 |
| The artificial Calculus Bovis | 3 | 2.0 | 1.5 |
| Margarita | 2.4 | 2.4 | 2.0 |
| Lanoline | 15 | 20 | 25 |
| Vaseline | 490 | 460 | 412 |
The prescription of the foregoing description is prepared into ointment as follows:
A, Cinnabaris water is flown into impalpable powder;
B, Margarita, Olibanum, Myrrha are ground into fine powder;
C, Gypsum Fibrosum (forging) is ground into fine powder, crosses 150 mesh sieves;
D, with Camphora, artificial Calculus Bovis, Borneolum Syntheticum and Calamina facing-up, cross 160 mesh sieves;
E, get Oleum Ricini in addition and endure to dripping into pearl, cold slightly, add Margarita, Olibanum, Myrrha and particulate Colophonium, stir and make complete molten; Add lanoline and an amount of vaseline again, make fusing fully, filter through 120 mesh sieves;
F, adding Gypsum Fibrosum fine powder stir, and are chilled to below 40 ℃;
G, camphorate, artificial Calculus Bovis, Borneolum Syntheticum, grind well;
H, add the Cinnabaris fine powder, mixing and processing.Semi-finished product become red ointment through fill after the assay was approved.Lucifuge, the airtight shady and cool drying place of putting preserves.
Can further the red ointment compositions of step H gained stand be applied to and mount on the backing material, process the externally applied ointment that can supply skin to stick.
Embodiment 4,5,6,7: prepare topical agent of the present invention
The formula ratio of the embodiment of the invention 4,5,6,7 topical agents is (weight portion is with the preparation in batches of 5000 grams) as follows:
| Form | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 |
| Cinnabaris | 200 | 200 | 200 | 200 |
| Calamina | 20 | 160 | 120 | 30 |
| Borneolum Syntheticum | 125 | 25 | 50 | 100 |
| Olibanum | 10 | 80 | 60 | 15 |
| Myrrha | 75 | 10 | 20 | 50 |
| Colophonium | 50 | 160 | 140 | 70 |
| Oleum Ricini | 90 | 20 | 30 | 75 |
| Gypsum Fibrosum (forging) | 10 | 80 | 50 | 15 |
| Camphora | 120 | 20 | 30 | 100 |
| The artificial Calculus Bovis | 0.5 | 10 | 5 | 1 |
| Margarita | 10 | 0.5 | 1 | 5 |
| Cera Flava | 30 | 2 | 40 | 7.5 |
| Vaseline | 500 | 200 | 300 | 700 |
The method of reference implementation example 1 prepares above embodiment 4,5,6,7, gets ointment compositions.
Embodiment 8-11: preparation the present inventionTopical agent
The formula ratio of embodiment of the invention 8-11 topical agent is (weight portion is with the preparation in batches of 5000 grams) as follows:
| Form | Embodiment 8 | Embodiment 9 | Embodiment 10 | Embodiment 11 |
| Cinnabaris | 200 | 200 | 200 | 200 |
| Calamina | 40 | 100 | 55 | 70 |
| Borneolum Syntheticum | 80 | 60 | 60 | 75 |
| Olibanum | 20 | 50 | 25 | 35 |
| Myrrha | 40 | 25 | 25 | 40 |
| Colophonium | 80 | 125 | 80 | 100 |
| Oleum Ricini | 60 | 35 | 40 | 45 |
| Gypsum Fibrosum (forging) | 25 | 40 | 25 | 30 |
| Camphora | 90 | 40 | 50 | 75 |
| The artificial Calculus Bovis | 1.25 | 4 | 1.5 | 3.5 |
| Margarita | 4 | 1.5 | 2 | 2.5 |
| Stearic | 5 | 40 | 5 | 40 |
| Lanoline | 30 | 10 | ||
| Vaseline | 400 | 600 | 600 | 400 |
The method of reference implementation example 1 prepares above embodiment 8-11, gets ointment compositions.
B: Test Example part
For proof present composition medicine to skin skin ulcer class treatment of conditions effects such as comedo, skin sore, acnes, the present invention is through the checking of following in vitro tests, animal model and three levels such as clinical.
Test Example 1: extracorporeal bacteria inhibitor test (using embodiment 1 reagent to make an experiment):
The employing plating method on agar plate, places 37 ℃ of incubators after cultivating in 24 hours various bacterial classification inoculations, measures its inhibition zone diameter.The mean of getting three antibacterial rings is done the t check and is handled (* representes that significant difference is arranged in the table), and with plaster concentration with the bacillus pyocyaneus inhibition zone diameter is made Linear correlative analysis.
Table 1: embodiment 1 reagent variable concentrations plaster is to the bacteriostasis of In vitro culture antibacterial
Bacteriostatic test shows: no matter the present invention's combination all has stronger inhibitory action to gram negative bacteria or gram positive bacteria, have the broad-spectrum antiseptic effect, its inhibitory effect has tangible dose-effect relationship with strengthening with concentration.
The inventor is in other parallel test; Use each compositions of embodiment 2-11 to carry out above-mentioned test respectively; The inhibition zone diameter that the result is presented at 7 kinds of strains in the his-and-hers watches 1 under the 5%-80% drug level shows and the essentially identical result of embodiment 1 sample; For example 10%, under 40% two kind of concentration, each compositions of embodiment 2-11 differs less than 10% the inhibition zone diameter and embodiment 1 result of 7 kinds of strains.
Test Example 2, Cavia porcellus ulcer model (using embodiment 2 reagents to make an experiment)
Receive the examination district to be Cavia porcellus dorsal part skin.2d loses hair or feathers with 8% sodium sulfide solution before the test.Be fixed on the frame Cavia porcellus is prostrate during test, intramuscular injection ketalar 50mg/kg, animal gets into generalized anesthetic state behind the 3min.At 3 diameter 1.30cm of every guinea pig back excision,, reach the damaged circular fresh wound surface of full thick skin on fascia surface deeply earlier at a distance of 3cm.The back is coated with plaster, Colophonium (each 1.5g) and lid dry gauze respectively by drawing lots, and wrapping is fixing.Get tissue in the 10th day and 35 days after surgery and send the disease inspection.
Table 2: the histological examination result of postoperative different number of days
Test shows: the present composition can provide a good microenvironment for wound surface; Accelerate wound surface growth and healing, and the elasticity of healing back wound surface, wear resistance and tenacity all have in matched group; Show that mainly epithelization is complete, pathological changes such as no microulceration and pectination epithelium foot.Its subcutaneous granulation tissue is abundant, and blood fortune is sufficient, no inflammatory cell infiltration.
Test Example 3, clinical verification (using hereinafter embodiment 3 reagents to make an experiment):
Reagent of the present invention is through 600 routine system observation on Clinical Application, and selection medical history, the state of an illness, age, sex and suitable patient's 600 examples of original Therapeutic Method are observed as matched group.Cases such as the comedo that department of dermatologry selection diagnosis is set up, skin sore, acne.Male's 420 examples wherein, women's 180 examples, age distribution did not wait in 15-50 year in course of disease 10-30 days.
Comedo, skin sore, three kinds of common diseases of acne are carried out the clinical control treatment observes; It is even as far as possible when case is divided into groups; Wherein comedo in the test group, skin sore, each 200 example of three kinds of diseases of acne, comedo, skin sore, each 200 example of three kinds of diseases of acne in the matched group.
The cream drug that the test group reagent uses embodiment 3 to make; Commercially available Margarita acne cream ((2006) defend make up accurate word 26-XK-0223) is used in the matched group reagent, and a kind of ointment that is applicable to skin sore, acne, comedo etc. has the skin sore of dispeling, soft cutin, removes the pox functions such as demodicid mite of dispelling.The use amount of test group reagent and matched group reagent is smeared in right amount in the affected part according to people's usual experience when being used for comedo, skin sore, three kinds of diseases of acne, one day 3 times.Used 35 days continuously.
The clinical treatment of A, two groups of comedos relatively
Table 3: treatment group and matched group are to 1,7,14,30 day accumulative total cure rate of comedo treatment
| Natural law | 1 day | 7 days | 14 days | 30 days |
| Test group 200 examples | 0 | 20% | 80% | 92% |
| Matched group 200 examples | 0 | 5% | 45% | 85% |
Visible by table 3, the treatment group at 7,14,30 days accumulative total cure rate apparently higher than matched group.
The clinical treatment of B, two groups of skin sore relatively
Table 4: treatment group and matched group are to 1,7,14,30 day accumulative total cure rate of skin sore treatment
| Natural law | 1 day | 7 days | 14 days | 30 days |
| Test group 200 examples | 0 | 30% | 85% | 94% |
| Matched group 200 examples | 0 | 10% | 41% | 74% |
Visible by table 4, the treatment group at 7,14,30 days accumulative total cure rate apparently higher than matched group.
The clinical treatment of C, two groups of acnes relatively
Table 5: treatment group and matched group are to 1,7,14,30 days accumulative total cure rate of acne treatment
| Natural law | 1 day | 7 days | 14 days | 30 days |
| Test group 200 examples | 0 | 24.5% | 68% | 95% |
| Matched group 200 examples | 0 | 12% | 40.5% | 78% |
Visible by table 5, the treatment group at 7,14,30 days accumulative total cure rate apparently higher than matched group.
Test Example 4, model case (using embodiment 2 compositionss to make an experiment):
Case 1
Patient Wang, woman, 19 years old.Facial seat skin ulcer did not heal in 4 years; General red, the hair of meeting portion, especially forehead and dilator naris skin gives two coarse, a purulence pimple that have chestnut grain appearance and grain of rice appearance to differ in size when examining, or accompanies in the follicular orifice of most blackheads, expansion and can extrude the greasy appearance of white powder juice, and the expectorant gargalesthesia is arranged; Color of the leather is general very red behind the sun exposure; Sufferings aggravations, cervical region and chest and back also distribute, and disease belongs to the pimple pustular type skin ulcer of fullying recover from an illness.With the embodiment of the invention 2 compositionss smear outward, two week back skin lesion obviously reduce, the red commentaries on classics of color is light, skin lesion disappears basically after February, skin recovers normal.
Case 2
Patient Zhang, man, 42 years old, people from Qiaosi, Hangzhou.Not more for three months, be skin ulcer property ulcer of the lower limb through certain hospital diagnosis after patient's tibial tuberosity outside furuncle and phyma is burst, treatment is surplus invalid February.
Inspection: the patient grows medium, eutrophy, and cardiopulmonary are normal, lassitude loin and legs, local painful itching.Tibia outer rim tsu san li place has about 5 * 5 centimetres of ulcer surfaces, the small size ulcer that differs in size three places, pigmentation on every side; The normal skin of internal orifice neat in edge is slightly high; The skin ulcer face is slight spill, and the surface has the sepia slough topped, oozes out with a small amount of purulent secretion.Be diagnosed as skin ulcer property ulcer of the lower limb.
Control suitable temperature compensation QI and blood, set upright poison holding, removing the necrotic tissue looses tired, and granulation promoting is put on flesh.The side is for oral administration with bolus of ten powerful tonics, sooner or later respectively obeys a ball, and externally applied ointment sticks.Change dressings after five times with embodiment 2 plaster, the ulcer surface slough gradually moves back, the appearance that newly granulates, and pus complexion changed HUANGBAI(sic) is sent out thick, and continued closes up with plaster external application ten secondaries and heal, follows up a case by regular visits to for several times, does not have and recurs.
Claims (10)
1. topical agent; It comprises the medical material and the drug matrices of following component, and perhaps it is processed by medical material that comprises following component and drug matrices: Cinnabaris, Calamina, Borneolum Syntheticum, Olibanum, Myrrha, Colophonium, Oleum Ricini, Gypsum Fibrosum (forging), Camphora, artificial Calculus Bovis, Margarita.
2. according to the topical agent of claim 1, Cinnabaris is in 200 weight portions in its medical material:
The Calamina amount is the 20-160 weight portion;
The Borneolum Syntheticum amount is the 25-125 weight portion;
The Olibanum amount is the 10-80 weight portion;
Not having dose is the 10-75 weight portion;
The Colophonium amount is the 50-160 weight portion;
The Semen Ricini oil mass is the 20-90 weight portion;
Gypsum Fibrosum (forging) amount is the 10-80 weight portion;
The Camphora amount is the 20-120 weight portion;
Artificial Calculus Bovis's amount is the 0.5-10 weight portion; And/or
The Margarita amount is the 0.5-10 weight portion, and
The drug matrices amount is the 200-850 weight portion.
3. according to the topical agent of claim 1, wherein said drug matrices is an oleaginous base; Preferably, said drug matrices is selected from following one or more: lanoline, vaseline, paraffin, Cera Flava, tristearin, natural rubber, liquid paraffin; Preferably, comprise lanoline in the wherein said drug matrices, Cinnabaris is in 200 weight portions in its medical material, and the lanoline amount is the 5-50 weight portion; Preferably, comprise vaseline in the wherein said drug matrices, Cinnabaris is in 200 weight portions in its medical material, and the vaseline amount is the 200-800 weight portion.
4. according to the topical agent of claim 1, comprising:
Cinnabaris 200 weight portions,
Calamina 20-160 weight portion,
Borneolum Syntheticum 25-125 weight portion,
Olibanum 10-80 weight portion,
Myrrha 10-75 weight portion,
Colophonium 50-160 weight portion,
Oleum Ricini 20-90 weight portion,
Gypsum Fibrosum (forging) 10-80 weight portion,
Camphora 20-120 weight portion,
Artificial Calculus Bovis 0.5-10 weight portion,
Margarita 0.5-10 weight portion,
Drug matrices 200-850 weight portion;
Perhaps, comprising:
Cinnabaris 200 weight portions,
Calamina 30-120 weight portion,
Borneolum Syntheticum 50-100 weight portion,
Olibanum 15-60 weight portion,
Myrrha 20-50 weight portion,
Colophonium 70-140 weight portion,
Oleum Ricini 30-75 weight portion,
Gypsum Fibrosum (forging) 15-50 weight portion,
Camphora 30-100 weight portion,
Artificial Calculus Bovis 1-5 weight portion,
Margarita 1-5 weight portion,
Drug matrices 300-750 weight portion;
Perhaps, comprising:
Cinnabaris 200 weight portions,
Calamina 40-100 weight portion,
Borneolum Syntheticum 60-80 weight portion,
Olibanum 20-50 weight portion,
Myrrha 25-40 weight portion,
Colophonium 80-125 weight portion,
Oleum Ricini 35-60 weight portion,
Gypsum Fibrosum (forging) 25-40 weight portion,
Camphora 40-90 weight portion,
Artificial Calculus Bovis 1.25-4 weight portion,
Margarita 1.5-4 weight portion,
Drug matrices 400-650 weight portion;
Perhaps, comprising:
Cinnabaris 200 weight portions,
Calamina 50-80 weight portion,
Borneolum Syntheticum 65-75 weight portion,
Olibanum 20-35 weight portion,
Myrrha 25-35 weight portion,
Colophonium 85-110 weight portion,
Oleum Ricini 40-45 weight portion,
Gypsum Fibrosum (forging) 25-35 weight portion,
Camphora 50-75 weight portion,
Artificial Calculus Bovis 1.5-3.5 weight portion,
Margarita 2-3 weight portion,
Drug matrices 450-600 weight portion;
Perhaps, comprising:
Cinnabaris 180 weight portions,
Calamina 70 weight portions,
Borneolum Syntheticum 60 weight portions,
Olibanum 30 weight portions,
Myrrha 25 weight portions,
Colophonium 100 weight portions,
Oleum Ricini 40 weight portions,
Gypsum Fibrosum (forging) 28 weight portions,
Camphora 60 weight portions,
Artificial Calculus Bovis's 3 weight portions,
Margarita 2.4 weight portions,
Lanoline 20 weight portions,
Vaseline 490 weight portions;
Perhaps, comprising:
Cinnabaris 190 weight portions,
Calamina 60 weight portions,
Borneolum Syntheticum 70 weight portions,
Olibanum 20 weight portions,
Myrrha 30 weight portions,
Colophonium 80 weight portions,
Oleum Ricini 40 weight portions,
Gypsum Fibrosum (forging) 25 weight portions,
Camphora 70 weight portions,
Artificial Calculus Bovis's 2.0 weight portions,
Margarita 2.4 weight portions,
Lanoline 15 weight portions,
Vaseline 460 weight portions;
Perhaps, comprising:
Cinnabaris 200 weight portions,
Calamina 50 weight portions,
Borneolum Syntheticum 70 weight portions,
Olibanum 25 weight portions,
Myrrha 30 weight portions,
Colophonium 90 weight portions,
Oleum Ricini 40 weight portions,
Gypsum Fibrosum (forging) 30 weight portions,
Camphora 50 weight portions,
Artificial Calculus Bovis's 1.5 weight portions,
Margarita 2.0 weight portions,
Lanoline 25 weight portions,
Vaseline 412 weight portions.
5. according to each topical agent of claim 1-4, it is characterized in that:
Said each medical material is that the method through physical treatment joins in the said topical agent;
Said each medical material is to join in the said topical agent through the method that physical pulverization is handled; In one embodiment, said physical pulverization can be to be selected from following mode: water flies, mechanical activation comminution, grinding and combination thereof;
Said medicament is to be to be selected from following medicine type: plaster, ointment, plaster, ointment, paste, lotion, varnish, patch, gel, liniment, spray, emplastrum;
Comprising the crude drug total amount among the every 1000g of said topical agent is 100-900g; And/or
Said topical agent is the medicament of plaster.
6. the preparation that is combined in of following traditional Chinese medicines material is used for treating and/or preventing the for example purposes of the topical agent of diseases such as comedo, skin sore, acne of dermatosis: Cinnabaris, Calamina, Borneolum Syntheticum, Olibanum, Myrrha, Colophonium, Oleum Ricini, Gypsum Fibrosum (forging), Camphora, artificial Calculus Bovis, Margarita.
7. according to the purposes of claim 6, it is characterized in that Cinnabaris is in 200 weight portions in the said topical agent medical material:
The Calamina amount is the 20-160 weight portion;
The Borneolum Syntheticum amount is the 25-125 weight portion;
The Olibanum amount is the 10-80 weight portion;
Not having dose is the 10-75 weight portion;
The Colophonium amount is the 50-160 weight portion;
The Semen Ricini oil mass is the 20-90 weight portion;
Gypsum Fibrosum (forging) amount is the 10-80 weight portion;
The Camphora amount is the 20-120 weight portion;
Artificial Calculus Bovis's amount is the 0.5-10 weight portion; And/or
The Margarita amount is the 0.5-10 weight portion, and
The drug matrices amount is the 200-850 weight portion.
8. according to the purposes of claim 6-7, it is characterized in that,
Said drug matrices is an oleaginous base;
Said drug matrices is selected from following one or more: lanoline, vaseline, paraffin, Cera Flava, tristearin, natural rubber, liquid paraffin;
Comprise lanoline in the said drug matrices of said topical agent, Cinnabaris is in 200 weight portions in the medical material, and the lanoline amount is the 5-50 weight portion;
Comprise vaseline in the said drug matrices of said topical agent, Cinnabaris is in 200 weight portions in the medical material, and the vaseline amount is the 200-800 weight portion;
Each medical material is that method through physical treatment joins in the said compositions in the said topical agent;
Said topical agent is to be to be selected from following medicine type: plaster, ointment, plaster, ointment, paste, lotion, varnish, patch, gel, liniment, spray, emplastrum;
Comprising the crude drug total amount among the every 1000g of said topical agent is 100-900g; And/or
Said topical agent is the medicament of plaster.
9. according to the purposes of claim 6-8, it is characterized in that, comprise in the said topical agent:
Cinnabaris 200 weight portions,
Calamina 20-160 weight portion,
Borneolum Syntheticum 25-125 weight portion,
Olibanum 10-80 weight portion,
Myrrha 10-75 weight portion,
Colophonium 50-160 weight portion,
Oleum Ricini 20-90 weight portion,
Gypsum Fibrosum (forging) 10-80 weight portion,
Camphora 20-120 weight portion,
Artificial Calculus Bovis 0.5-10 weight portion,
Margarita 0.5-10 weight portion,
Drug matrices 200-850 weight portion;
Perhaps, comprise in the said topical agent:
Cinnabaris 200 weight portions,
Calamina 30-120 weight portion,
Borneolum Syntheticum 50-100 weight portion,
Olibanum 15-60 weight portion,
Myrrha 20-50 weight portion,
Colophonium 70-140 weight portion,
Oleum Ricini 30-75 weight portion,
Gypsum Fibrosum (forging) 15-50 weight portion,
Camphora 30-100 weight portion,
Artificial Calculus Bovis 1-5 weight portion,
Margarita 1-5 weight portion,
Drug matrices 300-750 weight portion;
Perhaps, comprise in the said topical agent:
Cinnabaris 200 weight portions,
Calamina 40-100 weight portion,
Borneolum Syntheticum 60-80 weight portion,
Olibanum 20-50 weight portion,
Myrrha 25-40 weight portion,
Colophonium 80-125 weight portion,
Oleum Ricini 35-60 weight portion,
Gypsum Fibrosum (forging) 25-40 weight portion,
Camphora 40-90 weight portion,
Artificial Calculus Bovis 1.25-4 weight portion,
Margarita 1.5-4 weight portion,
Drug matrices 400-650 weight portion;
Perhaps, comprise in the said topical agent:
Cinnabaris 200 weight portions,
The sweet 50-80 weight portion of stove,
Borneolum Syntheticum 65-75 weight portion,
Olibanum 20-35 weight portion,
Myrrha 25-35 weight portion,
Colophonium 85-110 weight portion,
Oleum Ricini 40-45 weight portion,
Gypsum Fibrosum (forging) 25-35 weight portion,
Camphora 50-75 weight portion,
Artificial Calculus Bovis 1.5-3.5 weight portion,
Margarita 2-3 weight portion,
Drug matrices 450-600 weight portion;
Perhaps, comprise in the said topical agent:
Cinnabaris 180 weight portions,
Calamina 70 weight portions,
Borneolum Syntheticum 60 weight portions,
Olibanum 30 weight portions,
Myrrha 25 weight portions,
Colophonium 100 weight portions,
Oleum Ricini 40 weight portions,
Gypsum Fibrosum (forging) 28 weight portions,
Camphora 60 weight portions,
Artificial Calculus Bovis's 3 weight portions,
Margarita 2.4 weight portions,
Lanoline 20 weight portions,
Vaseline 490 weight portions;
Perhaps, comprise in the said topical agent:
Cinnabaris 190 weight portions,
Calamina 60 weight portions,
Borneolum Syntheticum 70 weight portions,
Olibanum 20 weight portions,
Myrrha 30 weight portions,
Colophonium 80 weight portions,
Oleum Ricini 40 weight portions,
Gypsum Fibrosum (forging) 25 weight portions,
Camphora 70 weight portions,
Artificial Calculus Bovis's 2.0 weight portions,
Margarita 2.4 weight portions,
Lanoline 15 weight portions,
Vaseline 460 weight portions;
Perhaps, comprise in the said topical agent:
Cinnabaris 200 weight portions,
Calamina 50 weight portions,
Borneolum Syntheticum 70 weight portions,
Olibanum 25 weight portions,
Myrrha 30 weight portions,
Colophonium 90 weight portions,
Oleum Ricini 40 weight portions,
Gypsum Fibrosum (forging) 30 weight portions,
Camphora 50 weight portions,
Artificial Calculus Bovis's 1.5 weight portions,
Margarita 2.0 weight portions,
Lanoline 25 weight portions,
Vaseline 412 weight portions.
10. prepare the method for each said topical agent of claim 1-6, it may further comprise the steps:
A, Cinnabaris water is flown into impalpable powder; B, Margarita, Olibanum, Myrrha are ground into fine powder; C, Gypsum Fibrosum (forging) is ground into fine powder, crosses 150 mesh sieves; D, with Camphora, artificial Calculus Bovis, Borneolum Syntheticum and Calamina facing-up, cross 160 mesh sieves; E, get Oleum Ricini in addition and endure to dripping into pearl, cold slightly, add Margarita, Olibanum, Myrrha and particulate Colophonium, stir and make complete molten; Add optional drug matrices again, make fusing fully, filter through 120 mesh sieves; F, adding Gypsum Fibrosum fine powder stir, and are chilled to below 40 ℃; G, camphorate, artificial Calculus Bovis, Borneolum Syntheticum, grind well; H, adding Cinnabaris fine powder, mixing promptly gets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210234682.3A CN102697835B (en) | 2012-07-09 | 2012-07-09 | The topical agent for the treatment of disease of skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210234682.3A CN102697835B (en) | 2012-07-09 | 2012-07-09 | The topical agent for the treatment of disease of skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102697835A true CN102697835A (en) | 2012-10-03 |
| CN102697835B CN102697835B (en) | 2016-05-11 |
Family
ID=46891082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210234682.3A Active CN102697835B (en) | 2012-07-09 | 2012-07-09 | The topical agent for the treatment of disease of skin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102697835B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739728A (en) * | 2015-04-15 | 2015-07-01 | 杨德育 | Quick pox-removing liquor and preparation method thereof |
| CN105616681A (en) * | 2016-01-04 | 2016-06-01 | 马林 | Traditional Chinese medicinal composition for treating acne |
| CN106806593A (en) * | 2017-02-14 | 2017-06-09 | 镇平县尤普实业有限公司 | A kind of Chinese medicine composition for skin nursing |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169286A (en) * | 1996-06-21 | 1998-01-07 | 李笑雷 | Ointment of quickly removing acne without blackspot |
| CN1543930A (en) * | 2003-11-25 | 2004-11-10 | 李忠文 | Method for making plaster adhesive bandage |
-
2012
- 2012-07-09 CN CN201210234682.3A patent/CN102697835B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169286A (en) * | 1996-06-21 | 1998-01-07 | 李笑雷 | Ointment of quickly removing acne without blackspot |
| CN1543930A (en) * | 2003-11-25 | 2004-11-10 | 李忠文 | Method for making plaster adhesive bandage |
Non-Patent Citations (3)
| Title |
|---|
| 中国人民共和国卫生部颁药典委员会: "《中华人民共和国卫生部药品标准中药成方制剂》", 31 December 1998, 中国医药科技出版社 * |
| 杨敏等: "梅花点舌丸联合姜黄消痤搽剂治疗痤疮93例", 《医药导报》 * |
| 陈潍等: "痤疮方系列配合外治法治疗寻常痤疮238例临床观察", 《河北中医》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739728A (en) * | 2015-04-15 | 2015-07-01 | 杨德育 | Quick pox-removing liquor and preparation method thereof |
| CN105616681A (en) * | 2016-01-04 | 2016-06-01 | 马林 | Traditional Chinese medicinal composition for treating acne |
| CN106806593A (en) * | 2017-02-14 | 2017-06-09 | 镇平县尤普实业有限公司 | A kind of Chinese medicine composition for skin nursing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102697835B (en) | 2016-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2008140200A1 (en) | External compositions for the skin | |
| CN109431873B (en) | Composition for repairing and relieving skin inflammation | |
| CN104306358B (en) | Antipruritic scar liniment of dispelling | |
| US20160051595A1 (en) | External-use medicament for cleaning and care of the ovaries, vagina and vulva | |
| CN101129787A (en) | Burn cream | |
| CN102697835A (en) | External medicament for treating skin diseases | |
| CN102697855B (en) | Medicinal composition for treating skin diseases | |
| CN108785384A (en) | A kind of Chinese medicine composition containing zinc and its preparation for treating acne | |
| CN101181385B (en) | Medicament for dispelling scar and preparation method thereof | |
| CN108379350A (en) | A kind of eczema ointment and preparation method thereof | |
| CN108542805A (en) | Anti-acne compound essential oil preparation and its preparation method and application | |
| CN103721138B (en) | A kind of traditional Chinese medicine for external application and its preparation method treating rosacea | |
| CN105395899A (en) | External use dosage form of gastrodia elata | |
| CN106421590A (en) | Pharmaceutical preparation for treating color mottles and application of pharmaceutical preparation | |
| Prasetyo et al. | The application of moist exposed burn ointment (MEBO) and binahong leaves in treating partial thickness burn: A case report | |
| CN105287496B (en) | A kind of pharmaceutical composition and preparation method thereof for treating ichthyosis | |
| CN103432049A (en) | Composition with deodorization function | |
| CN101062085B (en) | Condyloma acuminata treating medicine | |
| CN103191163B (en) | Skin wound repairing pharmaceutical composition | |
| CN102379963A (en) | Skin wound treating ointment and preparation method thereof | |
| CN101361805B (en) | Traditional Chinese medicine for treating breast diseases | |
| RU2626673C1 (en) | Means for treatment of skin and mucosa diseases, for local use, which is anti-inflammatory, anti-bacterial, antiviral, wound-healung, anti-fungal | |
| CN101559131B (en) | Traditional Chinese medicinal composition for treating scabies and preparation method thereof | |
| CN104274540B (en) | Chinese medicine composition, preparation method and use containing tripterygium wilfordii | |
| CN102133286A (en) | Ointment for treating trauma and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |