CN102106816A - Resveratrol nanometer preparation and preparation method thereof - Google Patents
Resveratrol nanometer preparation and preparation method thereof Download PDFInfo
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- CN102106816A CN102106816A CN2010105925797A CN201010592579A CN102106816A CN 102106816 A CN102106816 A CN 102106816A CN 2010105925797 A CN2010105925797 A CN 2010105925797A CN 201010592579 A CN201010592579 A CN 201010592579A CN 102106816 A CN102106816 A CN 102106816A
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- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 title claims abstract description 56
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 title claims abstract description 56
- 235000021283 resveratrol Nutrition 0.000 title claims abstract description 56
- 229940016667 resveratrol Drugs 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000003814 drug Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000002537 cosmetic Substances 0.000 claims abstract description 5
- 235000013305 food Nutrition 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 35
- 238000009472 formulation Methods 0.000 claims description 27
- 239000003921 oil Substances 0.000 claims description 11
- 235000019198 oils Nutrition 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000003995 emulsifying agent Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- -1 polyoxyethylene Polymers 0.000 claims description 7
- 239000003381 stabilizer Substances 0.000 claims description 7
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 6
- 235000012424 soybean oil Nutrition 0.000 claims description 6
- 239000003549 soybean oil Substances 0.000 claims description 6
- 239000004359 castor oil Substances 0.000 claims description 5
- 210000000582 semen Anatomy 0.000 claims description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 125000005456 glyceride group Chemical group 0.000 claims description 4
- 239000000787 lecithin Substances 0.000 claims description 4
- 235000010445 lecithin Nutrition 0.000 claims description 4
- 229940067606 lecithin Drugs 0.000 claims description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 239000001384 succinic acid Substances 0.000 claims description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 4
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 3
- 235000019438 castor oil Nutrition 0.000 claims description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
- 238000005984 hydrogenation reaction Methods 0.000 claims description 3
- 229950007687 macrogol ester Drugs 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 2
- 235000013361 beverage Nutrition 0.000 claims description 2
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 2
- 235000005713 safflower oil Nutrition 0.000 claims description 2
- 239000003813 safflower oil Substances 0.000 claims description 2
- 239000000047 product Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 4
- 239000003960 organic solvent Substances 0.000 abstract description 3
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 6
- 238000011068 loading method Methods 0.000 description 3
- JVKUCNQGESRUCL-UHFFFAOYSA-N 2-Hydroxyethyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCCO JVKUCNQGESRUCL-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 229920001304 Solutol HS 15 Polymers 0.000 description 2
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 210000004681 ovum Anatomy 0.000 description 2
- 101100248253 Arabidopsis thaliana RH40 gene Proteins 0.000 description 1
- PYIXHKGTJKCVBJ-UHFFFAOYSA-N Astraciceran Natural products C1OC2=CC(O)=CC=C2CC1C1=CC(OCO2)=C2C=C1OC PYIXHKGTJKCVBJ-UHFFFAOYSA-N 0.000 description 1
- NDVRQFZUJRMKKP-UHFFFAOYSA-N Betavulgarin Natural products O=C1C=2C(OC)=C3OCOC3=CC=2OC=C1C1=CC=CC=C1O NDVRQFZUJRMKKP-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- IHPVFYLOGNNZLA-UHFFFAOYSA-N Phytoalexin Natural products COC1=CC=CC=C1C1OC(C=C2C(OCO2)=C2OC)=C2C(=O)C1 IHPVFYLOGNNZLA-UHFFFAOYSA-N 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000280 phytoalexin Substances 0.000 description 1
- 150000001857 phytoalexin derivatives Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of the preparation of biological medicaments, and relates to a resveratrol nanometer preparation and a preparation method thereof. The resveratrol nanometer preparation is characterized in that: the grain diameter of the resveratrol nanometer preparation is less than 300 nanometers; and the resveratrol nanometer preparation can be diluted by water in any ratio. The resveratrol nanometer preparation is prepared without organic solvent, and has the advantages of safety, stability and high medicine-carrying dosage. The resveratrol nanometer preparation has a simple preparation process, is suitable for industrial production, can be widely applied in fields of food, drinks, health-care products, cosmetics and medicines.
Description
Technical field
The invention belongs to the preparing technical field of bio-pharmaceutical, relate to a kind of resveratrol nanometer formulation and preparation method thereof.
Background technology
Resveratrol is some plants, as Fructus Vitis viniferae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Rhizoma Polygoni Cuspidati etc., and oozy a kind of phytoalexin when being subjected to the pathogen infringement, its chemical name is 3,5,4 '-trihydroxy benzene diene (trans-3,5,4 '-Trihydroxystilbene).Existing studies show that, resveratrol have antioxidation, defying age, anticancer, anti-inflammatory, blood sugar lowering and protect cardiovascular effect, can be widely used in health product, food, cosmetics, medicine and other fields, and market value is high.Yet, resveratrol water solublity extreme difference (the about 5mg/100ml of the dissolubility in the water), it is low directly to take the artifact availability, has limited the application of resveratrol greatly.
Chinese patent CN101759531A discloses a kind of supercritical fluid technology that utilizes, and by the mode of resveratrol recrystallization, reaches the purpose that increases resveratrol dissolubility in water.The remarkable shortcoming of this method is process conditions complexity, cost height, and has used acetone and other organic solvent in the preparation engineering, might cause the secondary pollution of resveratrol.U.S. Pat 2004116386A1, the disclosed method of Chinese patent CN101095664, CN101579291A all is by phosphatide complexes, reaches the method that increases the resveratrol dissolubility.Phosphatide complexes can significantly improve the fat-soluble of medicine, but its solubilising power is limited as pharmaceutical carrier, when medicament contg is too high, be dispersed in wherein resveratrol very easily crystalline deposit come out, limited the transformation of the way applicating and exploitation of agent in resveratrol thus.
Summary of the invention
An object of the present invention is to provide the resveratrol nanometer formulation that a kind of water-soluble is good, drug loading is high, and preparation method thereof, and overcome the deficiency of prior art products.
Another object of the present invention is the application of described resveratrol nanometer formulation in preparation food, beverage, cosmetics, health product and medicine.
For achieving the above object, a technical scheme of the present invention provides the resveratrol nanometer formulation, by weight, comprises: 1～20% resveratrol, 0～40% oil phase, the emulsifying agent of 40～95% weight portions; Described resveratrol nanometer formulation particle diameter is less than 300 nanometers, and can be diluted by the water arbitrary proportion.
In such scheme of the present invention:
Described oil phase is selected from one or more in soybean oil, Semen Maydis oil, safflower oil, Oleum Arachidis hypogaeae semen, the median chain triglyceride oil;
Described emulsifying agent is selected from one or more in lecithin, polyethyleneglycol-12-hydroxy stearin, polyoxyethylene castor oil, hydrogenation polyoxyethylene Oleum Sesami, Tween 80, tocofecol succinic acid macrogol ester, the Polyethylene Glycol caprylic/capric glyceride.
For drug loading that increases resveratrol or the hydration time that shortens preparation, in such scheme of the present invention, preferably, in preparation, add certain stabilizing agent, for the gross mass of resveratrol nanometer formulation, stabiliser content is 0～50%, and described stabilizing agent can be to be selected from ethanol, PEG400, glycerol, the propylene glycol one or more.
The preparation method of aforementioned resveratrol nanometer formulation, this method comprises the steps:
1) under 40～70 ℃ of conditions, with oil phase, emulsifying agent mixes mutually, and under the 500r/min stirring condition, said mixture is stirred to transparent clear;
2) with an amount of resveratrol and optional stabilizing agent, join in the prepared system of step 1), and, continue under the 500r/min condition to stir at 40～70 ℃, until the homogeneous system that forms the visible insoluble matter of slightly amber, no naked eyes, products therefrom is the resveratrol nanometer formulation.
The present invention compared with prior art has the following advantages and the salience effect:
A. drug loading height, good stability;
B. product has good water solublity, can dilute with the water arbitrary proportion, and not have resveratrol recrystallized precipitation, aqueous solution transparent clear;
C. preparation technology is simple, does not relate to organic solvent and participates in, and need not special installation, is suitable for suitability for industrialized production;
D. adjuvant is safe, and particle diameter is less than 300nm, and particle diameter can satisfy the drug administration by injection requirement less than 100nm under the optimal conditions.
E. easy to use, can be added directly into food, cosmetics, health product and medicine.
The specific embodiment
The present invention will be further described below in conjunction with embodiment, but the present invention is not limited to embodiment.
Embodiment 1
Under 40 ℃ of conditions, with 1 gram soybean oil, 1 gram median chain triglyceride oil (Tieling Beiya Medical Oil Co., Ltd.), 3 gram polyethyleneglycol-12-hydroxy stearin (Solutol HS 15, BASF), 0.2 gram Ovum Gallus domesticus Flavus lecithin (PC-98T, Japanese Q. P. Co.), under the 500rmp rotating speed, mixture is stirred to the system transparent clear; 0.5 gram resveratrol is added above-mentioned system, temperature is brought up to 70 ℃, under the 500rmp rotating speed, continue to stir 4 hours, do not have the homogeneous system of the visible insoluble matter of naked eyes until whole system, the amber viscous liquid of gained is Resveratrol content and is 8.8% nanometer formulation.
Embodiment 2
Under 70 ℃ of conditions, with 0.8 gram soybean oil, 0.3 gram tocofecol succinic acid macrogol ester (TPGS, Eastman), 0.5 gram Polyethylene Glycol caprylic/capric glyceride (
767, SASOL), under the 500rmp rotating speed, mixture is stirred to the system transparent clear; 0.4 gram resveratrol is added above-mentioned system, reduce the temperature to 40 ℃, under the 500rmp rotating speed, continue to stir 3 hours, do not have the homogeneous system of the visible insoluble matter of naked eyes until whole system, the amber viscous liquid of gained is Resveratrol content and is 20% nanometer formulation.
Embodiment 3
Under 60 ℃ of conditions, with 1 gram Oleum Arachidis hypogaeae semen, 0.5 gram soybean oil, 5 gram polyoxyethylene castor oils (
EL BASF), under the 500rmp rotating speed, is stirred to the system transparent clear with mixture; 0.7 gram resveratrol is added above-mentioned system, keep 60 ℃ temperature-resistant, under the 500rmp rotating speed, continue to stir 4 hours, do not have the homogeneous system of the visible insoluble matter of naked eyes until whole system, the amber viscous liquid of gained is Resveratrol content and is 9.7% nanometer formulation.
Embodiment 4
Under 40 ℃ of conditions, with 4.5 gram tocofecol succinic acid macrogol esters (TPGS, Eastman), 5 gram Polyethylene Glycol caprylic/capric glyceride (
Gattefosse), under the 500rmp rotating speed, mixture is stirred to the system transparent clear; Improve temperature to 60 ℃, continue to stir 3 hours under the 500rmp rotating speed, do not have the homogeneous system of the visible insoluble matter of naked eyes until whole system, the amber viscous liquid of gained is Resveratrol content and is 5% nanometer formulation.
Embodiment 5
Under 70 ℃ of conditions, with 0.8 gram refined maize oil (North China pharmacy), 3 gram hydrogenation polyoxyethylene castor oils (
RH40, BASF), 0.2 gram Ovum Gallus domesticus Flavus lecithin (PC-98T, Japanese Q. P. Co.) under the 500rmp rotating speed, is stirred to the system transparent clear with mixture; With 1.94 gram propylene glycol, 60 milligrams of resveratrols add above-mentioned system, under the 500rmp rotating speed, continue to stir 1 hour, do not have the homogeneous system of the visible insoluble matter of naked eyes until whole system, gained light amber viscous liquid is Resveratrol content and is 1% nanometer formulation.
Embodiment 6
Under 50 ℃ of conditions, with 0.2 gram soybean oil, median chain triglyceride oil in 0.2 gram (
812, SASOL), 1 gram Tween 80, (Solutol HS 15 BASF), under the 500rmp rotating speed, is stirred to the system transparent clear with mixture to 1 gram polyethyleneglycol-12-hydroxy stearin; With 0.1 gram resveratrol, 2.5 gram glycerol add above-mentioned system, and holding temperature, mixing speed condition are constant, continue to stir 1 hour, do not have the homogeneous system of the visible insoluble matter of naked eyes until whole system, gained light amber viscous liquid is Resveratrol content and is 2% nanometer formulation.
Embodiment 7
Product provided by the invention adopts laser particle analyzer (Malvern Zetasize 3000) to detect particle diameter.Laser particle analyzer detects the method for Emulsion particle diameter, is well-known to those skilled in the art.Before the measurement, sample dilutes 20 times with the Millipore ultra-pure water, and the result is as shown in table 1.
Table 1 resveratrol nanometer formulation particle diameter
| Sample | Particle diameter (nanometer) |
| Embodiment 1 | 279 |
| Embodiment 2 | 263 |
| Embodiment 3 | 75 |
| Embodiment 4 | 62 |
| Embodiment 5 | 157 |
| Embodiment 6 | 50 |
Embodiment 8
Respectively sample is carried out 5 times, 10 times, 30 times, 100 times dilutions with deionized water, and diluent is carried out accelerated test to investigate its stability; The accelerated test condition: the temperature degree is 40 ℃, and relative humidity is 75%.Place after 3 months, with above-mentioned diluent centrifugal 30min under the 4000rpm condition, observe naked eyes visible precipitate thing whether occurs, the result is as shown in table 2.
Table 2 resveratrol nanometer formulation centrifugal result under different diluting conditions
Claims (7)
1. a resveratrol nanometer formulation comprises resveratrol, oil phase, and emulsifying agent is characterized in that described resveratrol nanometer formulation particle diameter less than 300 nanometers, and can be diluted by the water arbitrary proportion.
2. resveratrol nanometer formulation according to claim 1, wherein, for the gross mass of resveratrol nanometer formulation, the content of resveratrol is 1～20%, described oil phase content is 0～40%, and described emulsifier content is 40～95%, and the content of stabilizing agent is 0～50%.
3. resveratrol nanometer formulation according to claim 1, wherein, described oil phase is selected from one or more in soybean oil, Semen Maydis oil, safflower oil, Oleum Arachidis hypogaeae semen, the median chain triglyceride oil.
4. resveratrol nanometer formulation according to claim 1, wherein, described emulsifying agent is selected from one or more in lecithin, polyethyleneglycol-12-hydroxy stearin, polyoxyethylene castor oil, hydrogenation polyoxyethylene castor oil, Tween 80, tocofecol succinic acid macrogol ester, the Polyethylene Glycol caprylic/capric glyceride.
5. resveratrol nanometer formulation according to claim 2, wherein, described stabilizing agent is selected from one or more in ethanol, PEG400, glycerol, the propylene glycol.
6. the preparation method of the described resveratrol nanometer formulation of claim 1, it is characterized in that: this method comprises the steps:
1) under 40～70 ℃ of conditions, with oil phase, emulsifying agent mixes mutually, and under the 500r/min stirring condition, said mixture is stirred to transparent clear;
2) with an amount of resveratrol and optional stabilizing agent, join in the prepared system of step 1), and, continue under the 500r/min condition to stir at 40～70 ℃, until the homogeneous system that forms the visible insoluble matter of slightly amber, no naked eyes, products therefrom is the resveratrol nanometer formulation.
7. according to the described resveratrol nanometer formulation of claim 1 to 5, the application in preparation food, beverage, cosmetics, health product and medicine.
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103120310A (en) * | 2011-11-20 | 2013-05-29 | 重庆还少堂生物技术有限责任公司 | Preparation method of resveratrol water-soluble dry powder |
| CN103142457A (en) * | 2013-01-17 | 2013-06-12 | 西安电子科技大学 | Resveratrol nanometer-preparation preparation method |
| CN103690487A (en) * | 2013-12-17 | 2014-04-02 | 武汉工程大学 | Carrier-free micro-nano resveratrol medicament and preparation and application thereof |
| CN104000866A (en) * | 2013-09-17 | 2014-08-27 | 黄桂淑 | Peanut bud seedling extract and application thereof |
| CN107496181A (en) * | 2017-10-20 | 2017-12-22 | 上海家化联合股份有限公司 | Solubilizing systems containing resveratrol |
| CN108114286A (en) * | 2018-01-12 | 2018-06-05 | 西南大学 | The application of gold nano load resveratrol |
| US20180243211A1 (en) * | 2015-08-28 | 2018-08-30 | Caliway Biopharmaceuticals Co., Ltd. | A pharmaceutical composition for reducing local fat and uses thereof |
| CN108967779A (en) * | 2018-07-10 | 2018-12-11 | 王芯茹 | A kind of preparation method of the compound solubilizer system drink containing resveratrol |
| CN109157508A (en) * | 2018-10-12 | 2019-01-08 | 沈阳药科大学 | A kind of resveratrol nanosuspension and preparation method thereof |
| CN110172373A (en) * | 2019-06-14 | 2019-08-27 | 中国农业科学院农产品加工研究所 | Application of the resveratrol in peanut oil |
| US11318110B2 (en) | 2015-08-28 | 2022-05-03 | Caliway Biopharmaceuticals Co., Ltd. | Pharmaceutical composition for reducing local fat and uses thereof |
| CN115227589A (en) * | 2022-09-05 | 2022-10-25 | 江南大学 | Stabilized resveratrol inclusion and preparation method thereof |
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| CN103120310A (en) * | 2011-11-20 | 2013-05-29 | 重庆还少堂生物技术有限责任公司 | Preparation method of resveratrol water-soluble dry powder |
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