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CN101822873A - Line focusing ultrasonic therapy probe - Google Patents

Line focusing ultrasonic therapy probe Download PDF

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CN101822873A
CN101822873A CN 201010166222 CN201010166222A CN101822873A CN 101822873 A CN101822873 A CN 101822873A CN 201010166222 CN201010166222 CN 201010166222 CN 201010166222 A CN201010166222 A CN 201010166222A CN 101822873 A CN101822873 A CN 101822873A
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shell
ultrasonic transducer
ultrasonic
probe
line
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惠春
黄斌峰
陈亚珠
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Shanghai Jiao Tong University
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Shanghai Jiao Tong University
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Abstract

The invention discloses a line focusing ultrasonic therapy probe in the technical field of medicinal therapy. The line focusing ultrasonic therapy probe comprises a shell, a therapeutic window, an ultrasonic transducer and a catheter, wherein the ultrasonic transducer is fixed inside the shell, the top of the shell is spherical, the bottom of the shell is provided with the catheter, the therapeutic window is arranged on the lateral surface of the shell, two ends of the ultrasonic transducer are fixed on the therapeutic window, and the catheter is connected with the ultrasonic transducer. The line focusing ultrasonic therapy probe is technically improved based on the traditional ultrasonic therapy probe, the ultrasonic is focused on the lateral surface of the probe to form a linear shape, the focusing area is oblong, the ultrasonic energy is comparatively dispersed, and the probe has large scanning range and little injury to a mucous membrane. The probe has short diameter and length, and an air bag is wrapped outside the probe so as to furthest reduce the injury to the inner wall of the nasal cavity.

Description

线聚焦超声治疗探头 Line Focused Ultrasound Therapy Probe

技术领域technical field

本发明涉及的是一种医疗技术领域的装置,尤其涉及的是一种线聚焦超声治疗探头。The invention relates to a device in the field of medical technology, in particular to a line-focused ultrasonic therapy probe.

背景技术Background technique

聚焦超声在医学领域主要应用于肿瘤治疗,其原理是通过一定的聚焦方式在靶组织内形成一个声强极高(数kw~10kw/cm2)的焦区。焦区内能量大量沉积,使位于其中的组织的温度在几秒内达到65℃以上,导致组织产生瞬时的凝固性坏死,而焦区外的组织仅有少量的能量沉积,所以基本不受损伤,最终达到靶向治疗肿瘤的目的。Focused ultrasound is mainly used in tumor treatment in the medical field. Its principle is to form a focal area with extremely high sound intensity (several kw-10kw/cm 2 ) in the target tissue through a certain focusing method. A large amount of energy is deposited in the focal area, so that the temperature of the tissue located in it reaches above 65°C in a few seconds, resulting in instantaneous coagulation necrosis of the tissue, while the tissue outside the focal area has only a small amount of energy deposition, so it is basically not damaged , and finally achieve the purpose of targeted therapy for tumors.

变应性鼻炎是一种常见的慢性疾病,其全球发病率已达15%~20%,变应性鼻炎是发生在鼻黏膜的变态反应性疾病,严重影响患者的生活质量,更可能伴发相邻器官的炎症。由于对于变应性鼻炎的发病机理不清楚,无法对症下药,因此药物对变应性鼻炎的效果并不好,目前国内外公认的有效的治疗手段是将下鼻甲区域变薄以减轻变态反应。常用的治疗手段是手术治疗和消融疗法,手术和消融的治疗区域在下鼻甲区域,要求尽量在不损伤鼻黏膜的情况下清除部分黏膜下组织。手术治疗通常会对鼻黏膜造成较大损伤,会带来后遗症。消融疗法包括射频、激光、等离子。聚焦超声不仅可以使黏膜下层组织坏死,破坏局部免疫细胞,减少其释放的细胞因子和炎性介质,通过破坏粘膜下层神经细胞降低神经兴奋性,而减轻鼻炎症状,而且对鼻黏膜几乎没有损伤,目前国内有少数临床研究表明聚焦超声对变应性鼻炎治疗效果很好。鼻腔内空间狭小,治疗部位特殊,传统的聚焦超声探头不能满足要求,需要一种新型的线聚焦超声治疗探头。Allergic rhinitis is a common chronic disease, and its global incidence rate has reached 15% to 20%. Allergic rhinitis is an allergic disease that occurs in the nasal mucosa, which seriously affects the quality of life of patients and is more likely to be accompanied by Inflammation of adjacent organs. Since the pathogenesis of allergic rhinitis is unclear, it is impossible to prescribe the right medicine, so the effect of medicine on allergic rhinitis is not good. At present, the effective treatment method recognized at home and abroad is to thin the inferior turbinate area to reduce allergy. The commonly used treatment methods are surgical treatment and ablation therapy. The treatment area of surgery and ablation is in the inferior turbinate area, and it is required to remove part of the submucosal tissue without damaging the nasal mucosa. Surgical treatment usually causes greater damage to the nasal mucosa, which may cause sequelae. Ablation therapy includes radiofrequency, laser, plasma. Focused ultrasound can not only cause submucosa tissue necrosis, destroy local immune cells, reduce the release of cytokines and inflammatory mediators, reduce nerve excitability by destroying submucosa nerve cells, and relieve rhinitis symptoms, but also cause almost no damage to the nasal mucosa. At present, a few domestic clinical studies have shown that focused ultrasound has a good effect on the treatment of allergic rhinitis. The space in the nasal cavity is narrow and the treatment site is special. Traditional focused ultrasound probes cannot meet the requirements. A new type of line focused ultrasound treatment probe is needed.

经过对现有技术的检索发现,中国发明专利公开号:CN101141996,名称:包含集成在治疗用超声换能器内的图像换能器的治疗用腔内探头,该探头包括:形成有导管的支承体,导管由用于至少一个治疗性换能器部件的安装头部延展,换能器部件具有发射聚焦超声波的有效表面积以及包括具有总表面积的球形正面。该探头的主体为球面自聚焦换能器部件,直径在33mm~40mm之间,与本发明对比,该探头也是用于腔内治疗,但是其体积要大得多,产生的聚焦超声成点状,强度更大,治疗时能量不易控制,不宜用于治疗狭小腔体内疾病。After searching the prior art, it is found that Chinese invention patent publication number: CN101141996, name: intracavity probe for treatment including an image transducer integrated in the ultrasonic transducer for treatment, the probe includes: a support formed with a catheter A body, a catheter extending from a mounting head for at least one therapeutic transducer component having an effective surface area for emitting focused ultrasound and comprising a spherical front face having a total surface area. The main body of the probe is a spherical self-focusing transducer part with a diameter between 33 mm and 40 mm. Compared with the present invention, the probe is also used for intracavitary treatment, but its volume is much larger, and the focused ultrasound generated is in the form of points , the intensity is greater, and the energy is not easy to control during treatment, so it is not suitable for treating diseases in narrow cavities.

发明内容Contents of the invention

本发明的目的在于克服现有技术的不足,提供一种线聚焦超声治疗探头,对传统的超声治疗探头的基础上做了技术改进,超声在探头的侧面聚焦成线状,焦域为长方形,超声能量较分散,扫描范围大且对黏膜损伤小。The purpose of the present invention is to overcome the deficiencies of the prior art and provide a line-focused ultrasonic treatment probe, which has been technically improved on the basis of the traditional ultrasonic treatment probe. The ultrasound is focused into a line on the side of the probe, and the focal area is a rectangle. Ultrasonic energy is scattered, the scanning range is large and the damage to the mucosa is small.

本发明是通过以下技术方案实现的,本发明包括:外壳、治疗窗、超声换能器和导管,其中:超声换能器固定于外壳的内部,外壳的顶部是球面,外壳的底部设有套管,治疗窗设于外壳的侧面,超声换能器的两端固定在治疗窗上,导管和超声换能器相连。The present invention is achieved through the following technical solutions, the present invention includes: a shell, a treatment window, an ultrasonic transducer and a catheter, wherein: the ultrasonic transducer is fixed inside the shell, the top of the shell is a spherical surface, and the bottom of the shell is provided with a sleeve The treatment window is arranged on the side of the shell, the two ends of the ultrasonic transducer are fixed on the treatment window, and the catheter is connected with the ultrasonic transducer.

所述的超声换能器是压电陶瓷制成,长度为4~6mm,超声换能器的截面是弧形,半径为4~6mm,弧度为60°~90°,超声换能器的弧形两端和治疗窗固定相连,聚焦深度在治疗窗外3~5mm。The ultrasonic transducer is made of piezoelectric ceramics with a length of 4-6 mm. The section of the ultrasonic transducer is arc-shaped with a radius of 4-6 mm and a radian of 60° to 90°. The arc of the ultrasonic transducer is The two ends of the shape are fixedly connected to the treatment window, and the focal depth is 3-5 mm outside the treatment window.

所述的治疗窗是长方形,其的大小和超声换能器相同。The treatment window is a rectangle whose size is the same as that of the ultrasonic transducer.

所述的外壳是圆柱体,外壳的顶部是球面,外壳上除治疗窗外都覆有安全气囊。The shell is a cylinder, and the top of the shell is spherical, and the shell is covered with airbags except the treatment window.

所述的套管内设有进水管、出水管和电缆,电缆和超声换能器相连,进水管和出水管铸造于外壳的底部。The casing is provided with a water inlet pipe, a water outlet pipe and a cable, the cable is connected with the ultrasonic transducer, and the water inlet pipe and the water outlet pipe are cast on the bottom of the shell.

所述的进水管和出水管的直径小于2mm,是金属制成。The diameters of the water inlet pipe and the water outlet pipe are less than 2mm and are made of metal.

所述的外壳是不锈钢制成,尺寸小于8mm*8mm*8mm。The shell is made of stainless steel, and the size is less than 8mm*8mm*8mm.

所述的外壳上覆有生物相容的薄膜。The shell is covered with a biocompatible film.

本发明工作时,将探头伸至鼻内下鼻甲区域,治疗窗紧贴下鼻甲,聚焦超声聚焦于黏膜下3~5mm区域,探头往前方推进完成对下鼻甲区域的扫描。扫描区域为长方形,宽度为超声换能器的宽度,长度为探头往前推进的距离。When the present invention works, the probe is extended to the inferior turbinate region of the nose, the treatment window is close to the inferior turbinate, the focused ultrasound is focused on the submucosal 3-5mm region, and the probe is pushed forward to complete the scanning of the inferior turbinate region. The scanning area is rectangular, the width is the width of the ultrasonic transducer, and the length is the distance the probe is advanced.

本发明相比现有技术具有以下优点:本发明在传统的超声治疗探头的基础上做了技术改进,超声在探头的侧面聚焦成线状,焦域为长方形,超声能量较分散,扫描范围大且对黏膜损伤小。探头直径和长度较小且外包气囊,最大程度上对减少了鼻腔内壁的损伤。Compared with the prior art, the present invention has the following advantages: the present invention has made technical improvements on the basis of the traditional ultrasonic treatment probe, the ultrasonic is focused into a line on the side of the probe, the focal area is a rectangle, the ultrasonic energy is dispersed, and the scanning range is large And less damage to the mucosa. The diameter and length of the probe are small and the outsourcing air bag reduces the damage to the inner wall of the nasal cavity to the greatest extent.

附图说明Description of drawings

图1是本发明的结构示意图;Fig. 1 is a structural representation of the present invention;

图2是本发明的横截面示意图;Fig. 2 is a schematic cross-sectional view of the present invention;

图3是超声换能器的结构示意图。Fig. 3 is a schematic structural diagram of an ultrasonic transducer.

具体实施方式Detailed ways

下面对本发明的实施例作详细说明,本实施例在以本发明技术方案为前提下进行实施,给出了详细的实施方式和具体的操作过程,但本发明的保护范围不限于下述的实施例。The embodiments of the present invention are described in detail below. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following implementation example.

如图1所示,本实施例包括:外壳1、治疗窗2、超声换能器3、套管4和内窥镜5,其中:超声换能器3固定于外壳1的内部,外壳1的顶部是球面,外壳1的底部设有套管4,治疗窗2设于外壳1的侧面,套管4和超声换能器3相连,内窥镜5置于套管4旁。As shown in Figure 1, the present embodiment includes: a casing 1, a treatment window 2, an ultrasonic transducer 3, a sleeve 4 and an endoscope 5, wherein: the ultrasonic transducer 3 is fixed inside the casing 1, and the casing 1 The top is spherical, the bottom of the shell 1 is provided with a sleeve 4 , the treatment window 2 is set on the side of the shell 1 , the sleeve 4 is connected with the ultrasonic transducer 3 , and the endoscope 5 is placed beside the sleeve 4 .

所述的超声换能器3通过支架6固定在外壳1内。The ultrasonic transducer 3 is fixed in the casing 1 through a bracket 6 .

所述的超声换能器3是压电陶瓷制成,长度为4~6mm,超声换能器3的截面是弧形,半径4~6mm,弧度为60°~90°,超声换能器3的弧形两端和治疗窗2相接触,聚焦深度在治疗窗2外3~5mm。The ultrasonic transducer 3 is made of piezoelectric ceramics with a length of 4-6mm. The two ends of the arc are in contact with the treatment window 2, and the focal depth is 3-5 mm outside the treatment window 2.

所述的治疗窗2的大小和超声换能器3相同,治疗窗2的长度和超声换能器3的弦长相等,宽度和超声换能器3的宽度相等,超声能够在探头的侧面聚焦成线状,焦域为长方形。治疗窗2上以生物相容的薄膜密封,方便超声波透过同时保证治疗时循环水不致流出。The size of the treatment window 2 is the same as that of the ultrasonic transducer 3, the length of the treatment window 2 is equal to the chord length of the ultrasonic transducer 3, the width is equal to the width of the ultrasonic transducer 3, and the ultrasound can be focused on the side of the probe In a linear shape, the focal area is a rectangle. The treatment window 2 is sealed with a biocompatible film, which facilitates the penetration of ultrasonic waves and ensures that circulating water will not flow out during treatment.

所述的外壳1是圆柱体,外壳1的顶部是球面,外壳1上除治疗窗2外都覆有安全气囊7,减少探头在鼻腔内移动时对鼻腔内组织的损伤The shell 1 is a cylinder, and the top of the shell 1 is a spherical surface. The shell 1 is covered with an airbag 7 except for the treatment window 2, so as to reduce the damage to the tissues in the nasal cavity when the probe moves in the nasal cavity.

所述的套管4内设有进水管8、出水管9和电缆10,电缆10和超声换能器3相连,进水管8和出水管9铸造于外壳1的底部。进水管和出水管的直径小于2mm,是金属制成。The casing 4 is provided with a water inlet pipe 8 , a water outlet pipe 9 and a cable 10 , the cable 10 is connected to the ultrasonic transducer 3 , and the water inlet pipe 8 and the water outlet pipe 9 are cast on the bottom of the casing 1 . The diameter of the water inlet pipe and the water outlet pipe is less than 2mm and is made of metal.

所述的外壳是不锈钢制成,尺寸小于8mm*8mm*8mm。The shell is made of stainless steel, and the size is less than 8mm*8mm*8mm.

所述的外壳1外部覆有生物相容的薄膜以确保整个探头不漏水。The outside of the shell 1 is covered with a biocompatible film to ensure that the entire probe is watertight.

Claims (8)

1.一种线聚焦超声治疗探头,包括:外壳、治疗窗、超声换能器和导管,其特征在于:所述的超声换能器的截面是弧形,半径为4~6mm,弧度为60°~90°,超声换能器的弧形两端和治疗窗固定相连,聚焦深度在治疗窗外3~5mm,超声换能器固定于外壳的内部,外壳的顶部是球面,外壳的底部设有套管,治疗窗设于外壳的侧面,超声换能器的两端固定在治疗窗上,导管和超声换能器相连。1. A line-focused ultrasonic therapy probe, comprising: a shell, a treatment window, an ultrasonic transducer and a catheter, characterized in that: the section of the ultrasonic transducer is arc-shaped, with a radius of 4 to 6mm and a radian of 60° °~90°, the arc-shaped ends of the ultrasonic transducer are fixedly connected with the treatment window, the focus depth is 3~5mm outside the treatment window, the ultrasonic transducer is fixed inside the shell, the top of the shell is spherical, and the bottom of the shell is equipped with The cannula and the treatment window are arranged on the side of the shell, the two ends of the ultrasonic transducer are fixed on the treatment window, and the catheter is connected with the ultrasonic transducer. 2.根据权利要求1所述的线聚焦超声治疗探头,其特征是,所述的超声换能器是压电陶瓷制成,长度为4~6mm。2. The probe for line-focused ultrasonic therapy according to claim 1, wherein the ultrasonic transducer is made of piezoelectric ceramics and has a length of 4-6 mm. 3.根据权利要求1所述的线聚焦超声治疗探头,其特征是,所述的治疗窗是长方形,长度和超声换能器的弦长相等,宽度和超声换能器的宽度相等。3 . The line-focused ultrasonic therapeutic probe according to claim 1 , wherein the therapeutic window is rectangular, the length is equal to the chord length of the ultrasonic transducer, and the width is equal to the width of the ultrasonic transducer. 4 . 4.根据权利要求1所述的线聚焦超声治疗探头,其特征是,所述的外壳是圆柱体,外壳的顶部是球面,外壳上除治疗窗外都覆有安全气囊。4. The line-focused ultrasound therapy probe according to claim 1, wherein the shell is a cylinder, the top of the shell is spherical, and the shell is covered with airbags except for the treatment window. 5.根据权利要求1所述的线聚焦超声治疗探头,其特征是,所述的套管内设有进水管、出水管和电缆,电缆和超声换能器相连,进水管和出水管铸造于外壳的底部。5. The line-focused ultrasonic therapeutic probe according to claim 1, characterized in that, the casing is provided with a water inlet pipe, a water outlet pipe and a cable, the cable is connected to the ultrasonic transducer, and the water inlet pipe and the water outlet pipe are cast in the casing bottom of. 6.根据权利要求5所述的线聚焦超声治疗探头,其特征是,所述的进水管和出水管的直径小于2mm。6. The line-focused ultrasound therapy probe according to claim 5, wherein the diameters of the water inlet pipe and the water outlet pipe are less than 2mm. 7.根据权利要求1或4所述的线聚焦超声治疗探头,其特征是,所述的外壳尺寸小于8mm*8mm*8mm。7. The line-focused ultrasonic therapy probe according to claim 1 or 4, characterized in that the size of the shell is smaller than 8mm*8mm*8mm. 8.根据权利要求7所述的线聚焦超声治疗探头,其特征是,所述的外壳上覆有生物相容的薄膜。8. The line-focused ultrasound therapy probe according to claim 7, wherein the outer casing is covered with a biocompatible film.
CN 201010166222 2010-05-07 2010-05-07 Line focusing ultrasonic therapy probe Pending CN101822873A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102580261A (en) * 2012-03-31 2012-07-18 上海交通大学 Focusing ultrasonic transducer device for treating superficial tumor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1708698A (en) * 2002-11-08 2005-12-14 皇家飞利浦电子股份有限公司 Method and apparatus for automatically setting transmit aperture and sidelobe reduction of an ultrasound transducer array
CN2796747Y (en) * 2005-05-26 2006-07-19 深圳市普罗惠仁医学科技有限公司 Spherical crown type concave ball surface ultrasonic transducer
CN101141996A (en) * 2005-03-15 2008-03-12 埃达普股份有限公司 Therapeutic endocavity probe comprising an image transducer integrated within a therapeutic ultrasound transducer
CN100415318C (en) * 2000-04-21 2008-09-03 特克斯索尼克斯公司 System for therapeutic manipulation of target tissue regions in patients using focused ultrasound
CN101468240A (en) * 2007-12-26 2009-07-01 重庆融海超声医学工程研究中心有限公司 Ultrasonic therapy head

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100415318C (en) * 2000-04-21 2008-09-03 特克斯索尼克斯公司 System for therapeutic manipulation of target tissue regions in patients using focused ultrasound
CN1708698A (en) * 2002-11-08 2005-12-14 皇家飞利浦电子股份有限公司 Method and apparatus for automatically setting transmit aperture and sidelobe reduction of an ultrasound transducer array
CN101141996A (en) * 2005-03-15 2008-03-12 埃达普股份有限公司 Therapeutic endocavity probe comprising an image transducer integrated within a therapeutic ultrasound transducer
CN2796747Y (en) * 2005-05-26 2006-07-19 深圳市普罗惠仁医学科技有限公司 Spherical crown type concave ball surface ultrasonic transducer
CN101468240A (en) * 2007-12-26 2009-07-01 重庆融海超声医学工程研究中心有限公司 Ultrasonic therapy head

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102580261A (en) * 2012-03-31 2012-07-18 上海交通大学 Focusing ultrasonic transducer device for treating superficial tumor

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