CN101822631B - Combination drug for repelling animal insects - Google Patents

Abstract

The present invention discloses a combination drug for repelling insects, comprising plant extract, mineral medicine, BAAPE, excipient and water, wherein the mass contents of the above components are respectively 10-50% of plant extract, 5-40% of mineral medicine, 1-40% of BAAPE, 10-60% of excipient and appropriate amount of water, and the above plant extract is extracted from one or more of garlic, lemongrass, calamus, snake exterminator, wormwood, impatiens, rosemary, camphor tree and borneol tree. The drug prepared by the technical scheme of the present invention can repel a variety of insects, has strong effect, long duration, and has a certain degree of therapeutic effect, and can effectively prevent the spread of infectious diseases transmitted through the skin. In addition, after rubbing, the skin does not feel greasy, does not stain clothes, is easy to clean after use, and can also play a moisturizing and moisturizing effect on the skin.

Description

Combination drug for repelling animal insects

technical field

The invention relates to a pharmaceutical composition, in particular to a combined medicine for repelling beast insects.

Background technique

Under special environmental conditions (such as humid or hot and humid jungles), various beasts and insects such as snakes, spiders, leeches, centipedes, ants, mosquitoes, cockroaches, cicadas, etc. usually form a nuisance to people's lives, and they have always been people's camping activities. thorny issues that are unavoidable during military, tourism, and officer-soldier training. After being injured by beast insects, it will also cause poisoning, skin damage, and the spread of infectious diseases such as malaria. It is even more important to prevent animal pests from nuisance and damage. The current commercially available mosquito repellent drugs are divided into two categories, one is chemical synthesis preparations, which have fast effects, but have side effects on human skin, and even cause skin damage, and chemical preparations usually cause some people with weak constitutions Allergic reactions; the other type is flavor medicines, which are mainly made of Chinese herbal medicine extracts, but these kinds of external use insect repellent medicines are single, less effective, and not long-lasting. Therefore develop easy to use, carry, safe, long-acting animal pest repellent, have very important civilian value and military significance.

The purpose of the present invention is exactly to research a kind of composite repellent suitable for large-scale equipment, which can meet the field operations, training and medical support of troops in the aforementioned special environment, and can also meet the needs of people's daily camping and tourism to repel beasts and insects.

Contents of the invention

The purpose of the present invention is to solve the defects of the above-mentioned existing insect repellent and mosquito medicine, and provide a composite repellent composition, which overcomes the single application range of existing animal insect repellent products, skin irritation and damage, short action time, and repellent. Avoiding the problem of weak efficacy, and it has the advantages of repelling a variety of animal insects, strong efficacy, and long duration, and has a certain degree of therapeutic effect, which can effectively prevent the spread of infectious diseases transmitted through the skin. Its characteristics can be simply referred to as "integration of repellence and prevention, integration of prevention and control, and prevention first". In addition, after rubbing, the skin has no greasy feeling, does not pollute the clothes, is easy to clean after use, and also has the effect of moisturizing and moisturizing the skin.

The technical scheme of the present invention to achieve the above-mentioned purpose is a combination drug for repelling animal insects, including plant extracts, mineral medicines, mosquito repellent ester (BAAPE) and excipients, and the mass content of each of the above-mentioned ingredients is respectively, plant extracts 10-50% content of mineral medicine, 5-40% content of mineral medicine, 1-40% content of DEET, 10-60% content of excipients, and appropriate amount of water. The above-mentioned plant extracts are obtained from Extracted from one or several kinds of garlic, lemongrass, calamus, shemimen, mugwort leaves, impatiens, rosemary, camphor tree, and dipterophyll.

Above-mentioned mineral medicine is realgar or sulfur or the mixture of both.

The above-mentioned excipients are one or more mixtures of gel base, pH regulator, humectant, preservative, stabilizer, co-solvent, solubilizer, and emulsifier. Among them, the gel base is one or more of silicone, hydroxypropyl cellulose, polysorbate, propylene glycol, polyethylene glycol, stearyl alcohol, carbomer, gelatin, and tragacanth gum. ; Moisturizing agent is glycerin or polyhydric alcohol or the mixture of both; Regulator is citric acid or triethanolamine; Preservative is paraben series.

The method of extracting the above-mentioned plants is to use supercritical carbon dioxide extraction or volatile oil extractor to extract one or more of garlic, lemongrass, calamus calamus, shemimen, mugwort leaves, impatiens, rosemary, camphor tree, and borneol. method or physical extraction method.

The combination medicine of the present invention can be made into a gel-type preparation or a solution-type preparation.

The advantages of the present invention are (1) the pharmaceutical composition is extracted from multi-flavored traditional Chinese medicines, and can be used for common animals and insects, and has multi-effect and long-term repelling effects; (3) This product has no toxic or side effects on the human body.

Detailed ways

Below in conjunction with specific embodiment, technical scheme of the present invention is described as follows with gel type and solution type respectively:

(1) Composition for repelling animal insects (gel type)

Plant extracts: Take garlic 10, citronella 5, Shichangpu 5, Shemimen 50, Artemisia argyi 10, Impatiens 5, Rosemary 5, Camphor tree 5, Borneo tree 5 respectively according to mass ratio, and the above-mentioned medicines are mixed by After supercritical carbon dioxide extraction, the volatile oil part is obtained, and the desired plant extract is obtained immediately after preparation.

Mineral drug micropowder: use realgar or sulfur or a mixture of the two to prepare mineral powder. In this embodiment, realgar and sulfur are ultrafinely pulverized and mixed in a ratio of 6:4 by mass.

Excipient excipients (base): Hydroxypropyl cellulose 1.5%, carbomer 9400.5%, propylene glycol 20%, methylparaben 0.03%, citric acid adjusted to pH 7, and deionized water in an appropriate amount.

After mixing the above-mentioned plant extracts, mineral medicines and mosquito repellent with the excipient (matrix) in a mass ratio of 1:1, respectively, add citric acid to the three-part mixture to adjust the pH value to 7, and then The three parts are respectively taken according to the mass percentages of 60%, 30% and 10%, mixed thoroughly and stirred, cooled and filled to obtain the gel-type animal pest repelling combined pharmaceutical preparation.

(2) Composition for repelling beasts and insects (solution type)

Plant extracts: Weigh 10 garlic, 10 lemongrass, 10 calamus, 40 snakes, 10 mugwort leaves, 10 impatiens, 5 rosemary, 2.5 camphor trees, and 2.5 borneols according to the mass ratio, and then pass the supercritical After carbon dioxide extraction, the volatile oil fraction is obtained to prepare plant extracts.

Mineral medicine micropowder: after ultrafine grinding of realgar and sulfur, mix evenly according to the mass ratio of realgar:sulfur 7:3, and prepare mineral medicine powder.

Excipient excipients (matrix): polyethylene glycol, triethanolamine, glycerin, ethanol, and deionized are mixed in a mass ratio of 5:2:1:1:1 to prepare the matrix.

After mixing the above-mentioned plant extracts, mineral medicines and mosquito repellent with the excipient (matrix) in a mass ratio of 1:1, respectively, add citric acid to the three-part mixture to adjust the pH value to 7, and then The three parts are respectively taken according to the mass percentages of 70%, 20% and 10%, mixed thoroughly and stirred, cooled and filled to obtain a solution-type animal pest repelling combined pharmaceutical preparation.

The above-mentioned gel-type or solution-type veterinary-repelling combination pharmaceutical preparation prepared by the technical solution of the present invention is applied on human skin to repel veterinary insects and prevent them from nuisance and injury. The functions of each component are: (1) Calamus calamus, garlic, citronella, mugwort leaves, camphor tree, rosemary, borneol tree, impatiens: repel mosquitoes, cockroaches, caterpillars, ants, flies, leeches, lice (2) Snake Miemen, sulfur, realgar: repel snakes, centipedes, spiders, toads, millipedes (millipedes), scorpions, earthworms, snakes, scorpions, leeches, earthworms and other animals; (3) Mosquito repellent: repelling flies, lice, ants, mosquitoes, cockroaches, cicadas and other animal insects; (3) hydroxypropyl cellulose: dispersant, thickener, film-forming agent; (4) Carbomer: thickening (5) Propylene Glycol: Solubilizer; (6) Methylparaben: Preservative; (7) Citric Acid: pH Regulator, Preservative.

Of course, the present invention can also use other excipients to prepare other dosage forms.

The above-mentioned technical solutions only reflect the preferred technical solutions of the technical solutions of the present invention, and some changes that those skilled in the art may make to certain parts reflect the principles of the present invention and fall within the protection scope of the present invention.

Claims (8)

1. A combination medicine for repelling animals and insects, comprising plant extracts, mineral medicines, mosquito-repellent ester (BAAPE) and excipients, characterized in that the mass content of each of the above-mentioned components is respectively, and the content of plant extracts is 10～ 50%, the content of mineral medicine is 5-40%, the content of DEET is 1-40%, the content of excipients is 10-60% and appropriate amount of water. The above-mentioned plant extracts are composed of garlic, citronella, calamus , Shemimen, Artemisia argyi, Impatiens, rosemary, camphor tree, and dipterophyll in the ratio of 10:5:5:50:10:5:5:5:5, and the ratio of realgar and sulfur in the ratio of 6:4 The ratio of garlic, lemongrass, calamus, shemimen, mugwort leaves, impatiens, rosemary, camphor tree, dipterocarp according to the ratio of 10:10:10:40:10:10:5:2.5:2.5, The mineral medicine realgar and sulfur are extracted and mixed according to the ratio of 7:3. 2. according to the described combination medicine of repelling animals and insects according to claim 1, it is characterized in that, excipients are gel matrix, pH regulator, humectant, preservative, stabilizer, cosolvent, solubilizer, emulsifier One or several mixtures. 3. according to the described combination medicine of repelling animals and insects according to claim 2, it is characterized in that the gel matrix in the excipient is silicone, hydroxypropyl cellulose, polysorbate, propylene glycol, polyethylene glycol, octadecyl Alcohol, carbomer, gelatin, tragacanth gum or a mixture of several. 4. The combination medicine for repelling animal pests according to claim 2, characterized in that, the humectant in the excipient is glycerin or polyol or a mixture of both. 5. The combination medicine for repelling animals and insects according to claim 2, characterized in that the pH regulator in the excipient is citric acid or triethanolamine. 6. The combination drug for repelling animals and insects according to claim 2, characterized in that the preservatives in the excipients are paraben series, and the mass percentage thereof is 0.05-2%. 7. The combination medicine for repelling animals and insects according to claim 1, characterized in that the combination medicine can be made into a gel-type preparation or a solution-type preparation. 8. According to claim 1, the combination medicine for repelling animals and insects is characterized in that the plant extract is garlic, citronella, calamus, snake-killing door, Artemisia argyi, Impatiens, rosemary, camphor tree, borneol tree Extracted by supercritical carbon dioxide extraction, volatile oil extractor or physical extraction.