CN101199872A - Double medicament controlled-release coating micropore ACS bracket - Google Patents
Double medicament controlled-release coating micropore ACS bracket Download PDFInfo
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- CN101199872A CN101199872A CNA2006101301637A CN200610130163A CN101199872A CN 101199872 A CN101199872 A CN 101199872A CN A2006101301637 A CNA2006101301637 A CN A2006101301637A CN 200610130163 A CN200610130163 A CN 200610130163A CN 101199872 A CN101199872 A CN 101199872A
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Abstract
The invention relates to a millipore coronary stent with double-drug-slow-released coatings The coronary stent is structured by a plurality of metal main-structural members and connecting rods, wherein, the metal main-structural member is a regular snake-shaped ring which is formed by connecting an arc segment and a snake segment; neighboring main-structural members are connected by the connecting rod to form a ring support of a cylinder-wall; a plurality of millipores are opened on the snake-shaped segment; an outer drug-slow-released coating is coated on all metal main-structural members and connecting rods; an inner drug-slow-released coating is filled in the millipores on the snake-shaped segment of the metal-main-structural members. The double-drug-slow-released coatings of the coronary stent, through the slow-released function of the polymer coatings, can guarantee that different drugs can release at the given drug-releasing speeds, so as to guarantee that the drugs can adopts different releasing orders and durative acting times according to different pathogenesis.
Description
Technical field
The present invention relates to the coronary artery bracket in medical material field, especially a kind of double medicament controlled-release coating micropore ACS bracket.
Background technology
Coronary angioplasty is a kind of new treatment means for the treatment of cardiovascular disease in recent years in the percutaneous balloon cavity, and the coronary stent art is being used for the treatment of of growing up on this basis and prevents coronary stenosis and restenosis method the most efficiently and effectively.Common metal rack behind implant into body since the metal surface directly and blood vessel wall and blood thigmic stimulus the rejection function of human body to foreign body, cause tunica intima hamartoplasia and smooth muscle cell proliferation and form restenosis.In recent years, occurred preventing that by coating on coronary artery bracket the medicine of smooth muscle cell proliferation from preventing restenosis that because the medicament categories that is coated on the rack surface is single, its effect has limitation; And the dose of coating is also very limited, and it is shorter to make medicine act on time of tube wall, therefore can not reach ideal therapeutic effect.Improve the medicine amount of carrying of support and increase medicament categories under this prerequisite that just need remain unchanged in the metal surface coverage rate of existing support, with prolong drug action time with increase Drug therapy widely, thereby the raising therapeutic effect is a problem that presses for solution.
Summary of the invention
The present invention overcomes the deficiencies in the prior art, a kind of double medicament controlled-release coating micropore ACS bracket is provided, its double medicament controlled-release coating is that application innovation type cochrome or rustless steel micropore support carry two kinds of medicines as platform, slow-release time by polymer carrier control medicine, two kinds of medicines are successively discharged, suppress vascular restenosis and thrombotic effect thereby reach.
The present invention is achieved through the following technical solutions:
A kind of double medicament controlled-release coating micropore ACS bracket, this micropore ACS bracket is made of a plurality of metallic body member, connecting rod, this metallic body member is the regular serpentine rings that arc section links to each other and forms with snakelike section, the adjacent metal main component is by the connecting rod connection and form the barrel ring support, on snakelike section, have a plurality of micropores, it is characterized in that: on metallic body member and connecting rod, all be coated with outer medicament controlled-release coating, in snakelike section micropore of metallic body member, be filled with the internal layer medicament controlled-release coating.
And, all being mixed with the polymer carrier in described outer medicament controlled-release coating and the internal layer medicament controlled-release coating, the part by weight of this polymer carrier and medication coat is 3: 1～10: 1.
And described outer medicament controlled-release coating is one of rapamycin or paclitaxel, its internal layer medicament controlled-release coating be pimecrolimus or propanoic acid chlorine doubly or one of them of esterdiol; Perhaps outer medicament controlled-release coating be pimecrolimus or propanoic acid chlorine doubly or esterdiol wherein it, its internal layer medicament controlled-release coating be rapamycin or paclitaxel it.
And described outer medicament controlled-release coating adopts ultrasonic atomization spraying or aerial spraying or direct coated technique preparation on the coronary artery bracket surface.
And described polymer carrier is polylactic acid-glycolic guanidine-acetic acid (PLGA), Vinalac 5920 (PBMA).
And the molar ratio n (dl-LA) of described polymer carrier polylactic acid-glycolic guanidine-acetic acid (PLGA) and Vinalac 5920 (PBMA)/n (GA) is 90/10～50/50, and molecular weight is 5000～400000.
Beneficial effect of the present invention and advantage are:
1. this coronary artery bracket double medicament controlled-release coating is by the slow releasing function of polymer coating, can guarantee that different pharmaceutical presses its specific drug release rate and discharge, thereby guarantee that medicine can adopt different release order and different continuous action time according to pathogenetic difference.
2. this coronary artery bracket double medicament controlled-release coating adopts the polymer carrier with retardation, can make medicine present stable release, can keep stable blood medicine valid density, reaches the restenosis and the thrombotic effect that suppress blood vessel.
3. the entrained medicament categories of this coronary artery bracket double medicament controlled-release coating increases, and can reach the effect that suppresses smooth muscle increment, reduction thrombosis, promotion healing and improve endothelial function according to the different mechanism of medicine.
4. the coating of the medicine of this coronary artery bracket double medicament controlled-release coating can be placed in rack surface and the micropore, and this design can improve the control of drug release rate and directivity greatly.
Description of drawings
Fig. 1 is the structural representation of coronary artery bracket of the present invention;
Fig. 2 is the snakelike section structure for amplifying cutaway view of Fig. 1.
The specific embodiment
The present invention is described in further detail by following examples, and present embodiment is illustrative, rather than determinate, can not limit protection scope of the present invention according to following examples.
Double medicament controlled-release coating micropore ACS bracket, this coronary artery bracket (referring to Fig. 1) is made of a plurality of metallic body member 1, connecting rod 2, this metallic body member is the regular serpentine rings that arc section 3 links to each other and forms with snakelike section 4, the adjacent metal main component is by the connecting rod connection and form the barrel ring support, on its snakelike section, have a plurality of micropores 5, be shaped on three micropores in the present embodiment on each snakelike section, the quantity of this micropore is come fixed as required.On metallic body member and connecting rod, all be coated with outer medicament controlled-release coating 6, in snakelike section micropore of metallic body member, be filled with internal layer medicament controlled-release coating 7.
This double medicament controlled-release coating is that application innovation type cochrome or rustless steel micropore support carry two kinds of medicines as platform, and this skin medicament controlled-release coating adopts ultrasonic atomization spraying or aerial spraying or direct coated technique preparation on the coronary artery bracket surface.
This polymer carrier is polylactic acid-glycolic guanidine-acetic acid (PLGA) and Vinalac 5920 (PBMA), and its molar ratio n (dl-LA)/n (GA) is 90/10～50/50, and molecular weight is 5000～400000.
The outer medicament controlled-release coating medicine of this coronary artery bracket double medicament controlled-release coating adopts rapamycin (also can adopt paclitaxel, the two action principle is basic identical, and present embodiment and the following examples all are example with the rapamycin).Internal layer medicament controlled-release coating medicine adopts propanoic acid chlorine doubly, outer medicament controlled-release coating adopts the ultrasonic atomization spraying coating process built on metallic body member and connecting rod surface, the internal layer medicament controlled-release coating is filled in a plurality of micropores on snakelike section, the molar ratio n (dl-LA) of the polymer carrier polylactic acid-glycolic guanidine-acetic acid (PLGA) that is adopted/n (GA) is 80/20, molecular weight is 200000, and polymer carrier and rapamycin and propanoic acid chlorine part by weight doubly is 7: 1.
Above-mentioned rapamycin and propanoic acid chlorine doubly can exchange.
The outer medicament controlled-release coating medicine of this coronary artery bracket double medicament controlled-release coating adopts rapamycin, internal layer medicament controlled-release coating medicine adopts pimecrolimus, outer medicament controlled-release coating adopts direct coated technique on metallic body member and connecting rod surface, the internal layer medicament controlled-release coating is filled in a plurality of micropores on snakelike section, the polymer carrier that adopts is Vinalac 5920 (PBMA), its molar ratio n (dl-LA)/n (GA) is 90/10～50/50, and molecular weight is 5000～400000.The part by weight of this polymer carrier and rapamycin and pimecrolimus is 3: 1.
Above-mentioned rapamycin and pimecrolimus can exchange.
The outer medicament controlled-release coating medicine of this coronary artery bracket double medicament controlled-release coating adopts rapamycin, internal layer medicament controlled-release coating medicine adopts esterdiol, outer medicament controlled-release coating adopts air-atomizing technology built on metallic body member and connecting rod surface, the internal layer medicament controlled-release coating is filled in a plurality of micropores on snakelike section, the molar ratio n (dl-LA) of the polymer carrier polylactic acid-glycolic guanidine-acetic acid (PLGA) that is adopted/n (GA) is 50/50, molecular weight is 400000, and the part by weight of polymer carrier and rapamycin and esterdiol is 10: 1.
Above-mentioned rapamycin and esterdiol can exchange.
Know-why of the present invention: this coronary artery bracket double medicament controlled-release coating is that application innovation type cochrome or rustless steel micropore support carry two kinds of medicines as platform, slow-release time by polymer carrier control medicine, two kinds of medicines are successively discharged, thereby reach in-stent restenosis and the thrombotic technology of suppressing.
Implant the pathogeny of back restenosis and thrombosis order according to coronary artery bracket, a class medicine that is coated on the restenosis process that can suppress complexity of rack surface at first discharges, when drug slow release acquires a certain degree blood drug level, the medicine that is placed in the micropore accumulator tank discharges once more, thus the formation once more of thrombosis after reaching the interior restenosis of inhibition blood vessel and preventing thrombosis and thrombolytic.
Claims (6)
1. double medicament controlled-release coating micropore ACS bracket, this micropore ACS bracket is made of a plurality of metallic body member, connecting rod, this metallic body member is the regular serpentine rings that arc section links to each other and forms with snakelike section, the adjacent metal main component is by the connecting rod connection and form the barrel ring support, on snakelike section, have a plurality of micropores, it is characterized in that: on metallic body member and connecting rod, all be coated with outer medicament controlled-release coating, in snakelike section micropore of metallic body member, be filled with the internal layer medicament controlled-release coating.
2. double medicament controlled-release coating micropore ACS bracket according to claim 1, it is characterized in that: all be mixed with the polymer carrier in described outer medicament controlled-release coating and the internal layer medicament controlled-release coating, the part by weight of this polymer carrier and medication coat is 3: 1～10: 1.
3. double medicament controlled-release coating micropore ACS bracket according to claim 1, it is characterized in that: described outer medicament controlled-release coating is one of rapamycin or paclitaxel, its internal layer medicament controlled-release coating be pimecrolimus or propanoic acid chlorine doubly or one of them of esterdiol; Perhaps outer medicament controlled-release coating be pimecrolimus or propanoic acid chlorine doubly or one of them of esterdiol, its internal layer medicament controlled-release coating is one of rapamycin or paclitaxel.
4. according to claim 1 or 2 or 3 described double medicament controlled-release coating micropore ACS brackets, it is characterized in that: described outer medicament controlled-release coating adopts ultrasonic atomization spraying or aerial spraying or direct coated technique preparation on the coronary artery bracket surface.
5. double medicament controlled-release coating micropore ACS bracket according to claim 2 is characterized in that: described polymer carrier is polylactic acid-glycolic guanidine-acetic acid (PLGA), Vinalac 5920 (PBMA).
6. double medicament controlled-release coating micropore ACS bracket according to claim 5, it is characterized in that: the molar ratio n (dl-LA) of described polymer carrier polylactic acid-glycolic guanidine-acetic acid (PLGA) and Vinalac 5920 (PBMA)/n (GA) is 90/10～50/50, and molecular weight is 5000～400000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101301637A CN101199872A (en) | 2006-12-14 | 2006-12-14 | Double medicament controlled-release coating micropore ACS bracket |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101301637A CN101199872A (en) | 2006-12-14 | 2006-12-14 | Double medicament controlled-release coating micropore ACS bracket |
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| CN101199872A true CN101199872A (en) | 2008-06-18 |
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| CNA2006101301637A Pending CN101199872A (en) | 2006-12-14 | 2006-12-14 | Double medicament controlled-release coating micropore ACS bracket |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810522A (en) * | 2009-01-30 | 2010-08-25 | 科迪斯公司 | Reservoir eluting stent |
| CN102665782A (en) * | 2009-09-20 | 2012-09-12 | 麦德托尼克瓦斯科尔勒公司 | Apparatus and methods for loading a drug eluting medical device |
| CN102869324A (en) * | 2010-03-02 | 2013-01-09 | 美敦力瓦斯科尔勒公司 | Stent with sinusoidal wave form and orthogonal end and method for making same |
| CN103566418A (en) * | 2013-08-13 | 2014-02-12 | 重庆大学 | Preparation method of multi-coating drug eluting intravascular stent |
| CN105030391A (en) * | 2015-07-07 | 2015-11-11 | 南昌大学 | Intravascular stent with surface textures |
| CN105902331A (en) * | 2016-04-08 | 2016-08-31 | 南京永明医疗器械有限公司 | Intravascular stent and preparation method thereof |
| CN106110404A (en) * | 2016-08-11 | 2016-11-16 | 成都嘉宝祥生物科技有限公司 | The manufacture method of catheter |
| CN108186173A (en) * | 2018-01-12 | 2018-06-22 | 付静 | A kind of reparation fusion type heart stent and its manufacturing method |
| CN110584851A (en) * | 2019-09-21 | 2019-12-20 | 山东百多安医疗器械有限公司 | Ultrasonic controlled-release grooved degradable microsphere drug-loaded stent and preparation method thereof |
| CN110801319A (en) * | 2019-11-15 | 2020-02-18 | 郑州美港高科生物科技有限公司 | Magnesium alloy vertebral artery degradable stent |
| CN113101024A (en) * | 2021-04-08 | 2021-07-13 | 哈尔滨医科大学 | Pulmonary Drug Eluting Stents and Stent Kits |
| CN116059013A (en) * | 2023-03-29 | 2023-05-05 | 中国人民解放军联勤保障部队第九二〇医院 | Absorbable capsule spacer for implantation in patella joint and method of making same |
-
2006
- 2006-12-14 CN CNA2006101301637A patent/CN101199872A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810522A (en) * | 2009-01-30 | 2010-08-25 | 科迪斯公司 | Reservoir eluting stent |
| CN102665782A (en) * | 2009-09-20 | 2012-09-12 | 麦德托尼克瓦斯科尔勒公司 | Apparatus and methods for loading a drug eluting medical device |
| CN102665782B (en) * | 2009-09-20 | 2014-07-09 | 麦德托尼克瓦斯科尔勒公司 | Methods for loading a drug into a chamber of cavity wire rod forming a hollow support |
| CN102869324A (en) * | 2010-03-02 | 2013-01-09 | 美敦力瓦斯科尔勒公司 | Stent with sinusoidal wave form and orthogonal end and method for making same |
| CN102869324B (en) * | 2010-03-02 | 2015-07-15 | 美敦力瓦斯科尔勒公司 | Stent with sinusoidal wave form and orthogonal end and method for making same |
| CN103566418A (en) * | 2013-08-13 | 2014-02-12 | 重庆大学 | Preparation method of multi-coating drug eluting intravascular stent |
| CN103566418B (en) * | 2013-08-13 | 2016-01-20 | 重庆大学 | A kind of preparation method of laminated coating drug eluting vascular support |
| CN105030391B (en) * | 2015-07-07 | 2018-07-20 | 南昌大学 | A kind of intravascular stent with Surface Texture |
| CN105030391A (en) * | 2015-07-07 | 2015-11-11 | 南昌大学 | Intravascular stent with surface textures |
| CN105902331A (en) * | 2016-04-08 | 2016-08-31 | 南京永明医疗器械有限公司 | Intravascular stent and preparation method thereof |
| CN106110404A (en) * | 2016-08-11 | 2016-11-16 | 成都嘉宝祥生物科技有限公司 | The manufacture method of catheter |
| CN108186173A (en) * | 2018-01-12 | 2018-06-22 | 付静 | A kind of reparation fusion type heart stent and its manufacturing method |
| CN110584851A (en) * | 2019-09-21 | 2019-12-20 | 山东百多安医疗器械有限公司 | Ultrasonic controlled-release grooved degradable microsphere drug-loaded stent and preparation method thereof |
| CN110801319A (en) * | 2019-11-15 | 2020-02-18 | 郑州美港高科生物科技有限公司 | Magnesium alloy vertebral artery degradable stent |
| CN113101024A (en) * | 2021-04-08 | 2021-07-13 | 哈尔滨医科大学 | Pulmonary Drug Eluting Stents and Stent Kits |
| CN116059013A (en) * | 2023-03-29 | 2023-05-05 | 中国人民解放军联勤保障部队第九二〇医院 | Absorbable capsule spacer for implantation in patella joint and method of making same |
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Owner name: CHEN YIWEI Free format text: FORMER OWNER: TIANJIN CITY KAIDIYA MEDICAL EQUIPMENT CO., LTD. Effective date: 20090417 |
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Effective date of registration: 20090417 Address after: Tianjin Huayuan Industrial Park Plaza Madison 6-1-1802 Applicant after: Chen Yiwei Address before: Tianjin Haitai green industry base 2 door 301 seat F Applicant before: Kaidiya Medical Appliances Co., Ltd. |
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Owner name: TIANJIN KAIDIYA MEDICAL EQUIPMENT CO., LTD. Free format text: FORMER OWNER: CHEN YIWEI Effective date: 20100115 |
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Effective date of registration: 20100115 Address after: Tianjin Haitai green industry base F 2 door 301 seat post encoding: 300384 Applicant after: Kaidiya Medical Appliances Co., Ltd. Address before: Tianjin Huayuan Industrial Park Madison square 611802 post encoding: 300384 Applicant before: Chen Yiwei |
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Open date: 20080618 |