CN101176805A - 肺内给药装置 - Google Patents
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- 239000007788 liquid Substances 0.000 claims abstract description 67
- 239000003814 drug Substances 0.000 claims abstract description 18
- 238000012377 drug delivery Methods 0.000 claims abstract description 18
- 238000010438 heat treatment Methods 0.000 claims description 37
- 239000000919 ceramic Substances 0.000 claims description 15
- 239000000835 fiber Substances 0.000 claims description 11
- 239000002184 metal Substances 0.000 claims description 7
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- 239000011159 matrix material Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 claims description 2
- 239000006199 nebulizer Substances 0.000 claims description 2
- 238000000889 atomisation Methods 0.000 abstract description 8
- 239000002245 particle Substances 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 4
- 239000011859 microparticle Substances 0.000 abstract description 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 2
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
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Abstract
本发明涉及用于肺泡吸收药物的医疗器械，具体地说是一种将溶解于液体中的药物雾化成可深达肺泡的微粒的肺内给药装置，包括壳体及设在其一侧的吸嘴，在壳体内容置有电池、供液瓶及雾化器，其中：供液瓶的一端与吸嘴联通，另一端连有雾化器，壳体上、位于雾化器上方开有空气入口，在供液瓶的外表面开有气道；壳体上安装有动作开关。本发明雾化均匀、雾化粒子小，平均直径可达1微米左右，是用于肺内吸收的最佳技术参数；设置的定量装置，可对给药量进行控制。本发明可用于毛细支气管及肺泡的给药。
Description
技术领域
本发明涉及用于肺泡吸收药物的医疗器械，具体地说是一种将溶解于液体中的药物雾化成可深达肺泡的微粒的肺内给药装置。
背景技术
现有用于医疗目的的肺内给药装置大多分为高压气罐的喷射装置和超声雾化装置，目前广泛应用于临床及家庭中，使肺泡吸收药物。而现有的肺内给药装置虽然代表了一个技术的发展阶段，但同时也存在着不便于携带，雾化粒子过大，雾化剂吸入量不可控制等缺陷。
发明内容
本发明的目的在于提供一种肺内给药装置，在利用该给药装置时雾化粒子小，雾化均匀，还可以控制给药量。
本发明的目的是通过以下技术方案来实现的：
本发明包括壳体及设在其一侧的吸嘴，在壳体内容置有电池、供液瓶及雾化器，其中：供液瓶的一端与吸嘴联通，另一端连有雾化器，壳体上、位于雾化器上方开有空气入口，在供液瓶的外表面开有气道；壳体上安装有动作开关。
其中：所述雾化器为射流加热雾化器，包括供液结构体及加热体，供液结构体为多孔体结构或纤维结构，其一端开有射流孔，另一端设有凸起，加热体容置于供液结构体内，供液瓶中的药液透过供液结构体进入其体内；所述雾化器为浸润加热雾化器，包括供液结构体及加热体，供液结构体为多孔体结构或纤维结构，其一端设有凸起，加热体安装在另一端，供液瓶中的药液透过供液结构体进入其体内；所述加热体可为金属电热丝、导电陶瓷或PTC陶瓷；在空气入口与雾化器之间还设有气液隔离膜；在壳体内加设有定量装置；所述壳体上还开有清洗管道；在壳体的空气入口处加设有空气过滤片；所述供液瓶为多孔体结构或纤维结构；所述动作开关可为手动开关，或可用气压/气流传感器、霍尔器件、半导体力敏芯片、半导体矩阵热电桥芯片或电容及电感式传感器制成。
本发明的优点与积极效果为：
1.本发明雾化均匀、雾化粒子小，平均直径可达1微米左右，是用于肺内吸收的最佳技术参数。
2.本发明设有定量装置，可对给药量进行控制。
附图说明
图1为本发明的结构示意图；
图2为图1的右视图；
图3为本发明射流加热雾化器的结构示意图；
图4为图3的右视图；
图5为本发明浸润加热雾化器的结构示意图；
图6为图5的右视图。
具体实施方式
下面结合附图对本发明作进一步详述。
如图1、图2所示，本发明包括壳体10及设在其一侧的吸嘴2，壳体10内容置有电池1、供液瓶3及雾化器5。供液瓶3为多孔体结构或纤维结构，可以更换；供液瓶3的一端与吸嘴2联通，另一端接触有雾化器5，在供液瓶3的外表面开有气道12。壳体10上、位于雾化器5上方开有空气入口，入口处设有空气过滤片9，吸入的外界空气通过其过滤后进入壳体10内。在空气入口与雾化器之间设有气液隔离膜8，用于隔开药液及空气，使整个装置不漏液。壳体10上安装有动作开关7，其与电池1及雾化器5串联成回路。动作开关7可为手动开关，或可用气压/气流传感器、霍尔器件、半导体力敏芯片、半导体矩阵热电桥芯片或电容及电感式传感器制成。为了对给药的剂量进行控制，可在壳体10内加设一定量装置6。还可在壳体10上开有清洗管道4。
如图3、图4所示，雾化器5可为射流加热雾化器，包括供液结构体101及加热体102，供液结构体101为多孔体结构或纤维结构，其一端开有射流孔103，另一端设有凸起104，加热体102容置于供液结构体101内，供液瓶3中的药液透过供液结构体101进入其体内。加热体102可为金属电热丝、导电陶瓷或PTC陶瓷。射流加热雾化器是利用吸入气流在射流孔103内进行一次雾化，喷射在加热体102上进行二次雾化。
如图5、图6所示，雾化器5可为浸润加热雾化器，包括供液结构体201及加热体202，供液结构体201为多孔体结构或纤维结构，其一端设有凸起204，加热体202安装在另一端，供液瓶3中的药液透过供液结构体201进入其体内。加热体102可为金属电热丝、导电陶瓷或PTC陶瓷。浸润加热雾化器是用加热体202直接对供液结构体201加热，使药液雾化。
两种结构的雾化器中，位于一端的凸起104、204与供液瓶3相连接，供液瓶3中的药液逐渐透过供液结构体进到其内。供液结构体是用泡沫陶瓷、微孔陶瓷、多孔金属、不锈钢纤维毡或化学纤维成型开孔制成。加热体是用微孔陶瓷骨架上绕有金属电热材料制成，也可直接用导电陶瓷或PTC陶瓷材料制成的带烧结电极的多孔体。加热体的表面烧结成高温釉以固定沸石颗粒，沸石颗粒由天然沸石、人造无机微孔陶瓷或氧化铝颗粒制成。
本发明的工作原理为：药物经丙二醇溶解后，药液装入可更换的供液瓶3中。将供液瓶3放入壳体10内，与雾化器5接触并对雾化器供液。当使用者对吸嘴2吸气时，按动动作开关7、电路接通，电池1对雾化器5供电，加热体102、202开始加热。使用者吸气，工作指示灯11发光，外界空气经空气过滤片9过滤后进入壳体10内，经气液隔离膜8后与药液混合，被雾化器5雾化。雾化器5产生的气溶胶经气道12、再通过吸嘴2被使用者吸入肺中。定量装置6可为微处理器，预先设定好每次给药的剂量，对雾化过程进行雾化定量。
使用后，当需要时，使用者可用水或乙醇溶液通过清洗管道4对装置进行清洗。
本发明可用于毛细支气管及肺泡的给药。
Claims (11)
1.一种肺内给药装置，其特征在于：包括壳体(10)及设在其一侧的吸嘴(2)，在壳体(10)内容置有电池(1)、供液瓶(3)及雾化器(5)，其中：供液瓶(3)的一端与吸嘴(2)联通，另一端连有雾化器(5)，壳体(10)上、位于雾化器(5)上方开有空气入口，在供液瓶(3)的外表面开有气道(12)；壳体(10)上安装有动作开关(7)。
2.按权利要求1所述的肺内给药装置，其特征在于：所述雾化器(5)为射流加热雾化器，包括供液结构体(101)及加热体(102)，供液结构体(101)为多孔体结构或纤维结构，其一端开有射流孔(103)，另一端设有凸起(104)，加热体(102)容置于供液结构体(101)内，供液瓶(3)中的药液透过供液结构体(101)进入其体内。
3.按权利要求2所述的肺内给药装置，其特征在于：所述加热体(102)可为金属电热丝、导电陶瓷或PTC陶瓷。
4.按权利要求1所述的肺内给药装置，其特征在于：所述雾化器(5)为浸润加热雾化器，包括供液结构体(201)及加热体(202)，供液结构体(201)为多孔体结构或纤维结构，其一端设有凸起(204)，加热体(202)安装在另一端，供液瓶(3)中的药液透过供液结构体(201)进入其体内。
5.按权利要求4所述的肺内给药装置，其特征在于：所述加热体(102)可为金属电热丝、导电陶瓷或PTC陶瓷。
6.按权利要求1所述的肺内给药装置，其特征在于：在空气入口与雾化器(5)之间还设有气液隔离膜(8)。
7.按权利要求1所述的肺内给药装置，其特征在于：在壳体(10)内加设有定量装置(6)。
8.按权利要求1所述的肺内给药装置，其特征在于：所述壳体(10)上还开有清洗管道(4)。
9.按权利要求1所述的肺内给药装置，其特征在于：在壳体(10)的空气入口处加设有空气过滤片(9)。
10.按权利要求1所述的肺内给药装置，其特征在于：所述供液瓶(3)为多孔体结构或纤维结构。
11.按权利要求1所述的肺内给药装置，其特征在于：所述动作开关(7)可为手动开关，或可用气压/气流传感器、霍尔器件、半导体力敏芯片、半导体矩阵热电桥芯片或电容及电感式传感器制成。
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101484642A CN100536951C (zh) | 2006-11-11 | 2006-11-11 | 肺内给药装置 |
| PCT/CN2007/003181 WO2008058455A1 (fr) | 2006-11-11 | 2007-11-09 | Dispositif d'administration d'un médicament pour affections pulmonaires |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101484642A CN100536951C (zh) | 2006-11-11 | 2006-11-11 | 肺内给药装置 |
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| Publication Number | Publication Date |
|---|---|
| CN101176805A true CN101176805A (zh) | 2008-05-14 |
| CN100536951C CN100536951C (zh) | 2009-09-09 |
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| CNB2006101484642A Expired - Fee Related CN100536951C (zh) | 2006-11-11 | 2006-11-11 | 肺内给药装置 |
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| CN (1) | CN100536951C (zh) |
| WO (1) | WO2008058455A1 (zh) |
Cited By (131)
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| WO2010145468A1 (zh) * | 2009-06-19 | 2010-12-23 | Li Wenbo | 高频感应雾化装置 |
| CN102553039A (zh) * | 2010-12-17 | 2012-07-11 | 陈庆堂 | 药粉吸嘴及应用 |
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| WO2008058455A1 (fr) | 2008-05-22 |
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