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CN101111599B - 用于治疗细菌感染的表达载体 - Google Patents

用于治疗细菌感染的表达载体 Download PDF

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Publication number
CN101111599B
CN101111599B CN2004800448525A CN200480044852A CN101111599B CN 101111599 B CN101111599 B CN 101111599B CN 2004800448525 A CN2004800448525 A CN 2004800448525A CN 200480044852 A CN200480044852 A CN 200480044852A CN 101111599 B CN101111599 B CN 101111599B
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CN
China
Prior art keywords
expression vector
gram
bacteria
colicin
bacteriocin
Prior art date
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Expired - Fee Related
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CN2004800448525A
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English (en)
Chinese (zh)
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CN101111599A (zh
Inventor
迈克尔·E·斯泰尔斯
马里乌斯·雅格布斯·范·别尔卡姆
王莉茹
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Canbiocin Inc
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Canbiocin Inc
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Publication of CN101111599A publication Critical patent/CN101111599A/zh
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Publication of CN101111599B publication Critical patent/CN101111599B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2004800448525A 2004-12-14 2004-12-14 用于治疗细菌感染的表达载体 Expired - Fee Related CN101111599B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA2004/002127 WO2006063425A1 (fr) 2004-12-14 2004-12-14 Vecteur d'expression pour le traitement d'infections bactériennes

Publications (2)

Publication Number Publication Date
CN101111599A CN101111599A (zh) 2008-01-23
CN101111599B true CN101111599B (zh) 2013-01-23

Family

ID=36587476

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800448525A Expired - Fee Related CN101111599B (zh) 2004-12-14 2004-12-14 用于治疗细菌感染的表达载体

Country Status (4)

Country Link
EP (1) EP1836305A4 (fr)
CN (1) CN101111599B (fr)
CA (1) CA2592344A1 (fr)
WO (1) WO2006063425A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009011940A2 (fr) * 2007-04-06 2009-01-22 University Of Maryland, Baltimore Système de sélection de plasmide de la microcine h47
CN103289944A (zh) * 2012-03-01 2013-09-11 深圳市圣西马生物技术有限公司 一种分泌抗菌肽的乳酸链球菌基因工程制备方法与应用
CN110791509B (zh) * 2019-11-18 2023-09-08 深圳市圣西马生物技术有限公司 片球菌素优化表达序列、表达载体及其制作方法和菌株
CN119242550B (zh) * 2024-12-06 2025-03-04 吉林农业大学 表达etec抗原的新功能型乳酸菌及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0964693B1 (fr) 1996-09-05 2010-04-14 The Governors Of The University Of Alberta Nouvelles bacteriocines, nouveau systeme de transport et de vecteur et procede d'utilisation associe
AU8392698A (en) * 1997-07-09 1999-02-08 Governors Of The University Of Alberta, The Novel bacteriocins, transport and vector system and method of use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
J.K. McCormick 等.Colicin V can be produced by lactic acid bacteria.Letters in Applied Microbiology29.1999,2937-41. *
Marco J. van Belkum 等.Double-glycine-type leader peptides direct secretion ofbacteriocins by ABC transporters: colicin V secretion inLactococcus lactis.Molecular Microbiology23 6.1997,23(6),1293-1301.
Marco J. van Belkum 等.Double-glycine-type leader peptides direct secretion ofbacteriocins by ABC transporters: colicin V secretion inLactococcus lactis.Molecular Microbiology23 6.1997,23(6),1293-1301. *
Michael J. Fath 等.Purification and Characterization of Colicin V from Escherichiacoli Culture Supernatants.Biochemistry33 22.1994,33(22),6911-6917.
Michael J. Fath 等.Purification and Characterization of Colicin V from Escherichiacoli Culture Supernatants.Biochemistry33 22.1994,33(22),6911-6917. *

Also Published As

Publication number Publication date
WO2006063425A1 (fr) 2006-06-22
CN101111599A (zh) 2008-01-23
EP1836305A1 (fr) 2007-09-26
CA2592344A1 (fr) 2006-06-22
EP1836305A4 (fr) 2008-08-27

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Granted publication date: 20130123

Termination date: 20131214