CN101066125A - Instant donkey-hide gelatin powder and its preparation and preparation method - Google Patents
Instant donkey-hide gelatin powder and its preparation and preparation method Download PDFInfo
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Abstract
Description
[技术领域][technical field]
本发明涉及的是一种常用补药阿胶剂型改进和应用:速溶阿胶粉及其制剂和制备方法,属于食用保健品领域。The invention relates to the improvement and application of a common tonic donkey-hide gelatin dosage form: instant donkey-hide gelatin powder and its preparation and preparation method, which belong to the field of edible health products.
[背景技术][Background technique]
阿胶是中医常用的补血药,其性状甘平、入肺、肝、肾经,用于血虚出血,如咯血、吐血、便血及崩漏。含明胶蛋白、多种氨基酸、钙、硫等。效果是肯定的,但是由于口味异常,熬制费时,很多人熬制后难以服用。为此剂型的改进非常必要。改进的剂型、配方已有不少,如专利文献中03139055.2《速溶阿胶冲剂及其制备方法》,其工艺为:胶粉制备-沸腾制粒-烘干-包装。为了造粒必需加多种辅料,而阿胶异味仍然存在,不如人意。另一相关专利:200510023346.4《即食阿胶》构思不错,但有名无实,说明书中缺必要的技术特征,又未公开一点具体加工内容。让人实施中不是糊了就是膨化失败,不具有新颖性、创造性和实用性。Donkey-hide gelatin is a commonly used blood tonifying medicine in traditional Chinese medicine. Its properties are sweet and flat, and it enters the lung, liver and kidney meridian. It is used for blood deficiency and bleeding, such as hemoptysis, vomiting blood, blood in the stool and metrorrhagia. Contains gelatin protein, various amino acids, calcium, sulfur, etc. The effect is certain, but due to the abnormal taste and time-consuming cooking, it is difficult for many people to take it after boiling. For this reason the improvement of dosage form is very necessary. There are many improved dosage forms and formulas, such as "Instant Ejiao Granules and Its Preparation Method" in the patent document 03139055.2, the process is: rubber powder preparation-boiling granulation-drying-packaging. Must add multiple auxiliary materials for granulation, and the donkey-hide gelatin peculiar smell still exists, unsatisfactory. Another related patent: 200510023346.4 "Instant donkey-hide gelatin" has a good conception, but it is in name only, lacks necessary technical features in the instructions, and does not disclose any specific processing content. People are either confused or puffed in the implementation, and they do not have novelty, creativity and practicability.
[发明内容][Content of the invention]
因此,至今未解决口服阿胶异味,复方也让人难咽,复方口味好了,阿胶含量也少,效果差。本发明人经反复研究,多次改进试验,经多种加工方法验证,终于获得最好的加工方法,确定了典型制剂及其制备方法。Therefore, the peculiar smell of oral donkey-hide gelatin has not been solved so far, and the compound recipe is also difficult to swallow. The compound taste is good, but the donkey-hide gelatin content is also small, and the effect is poor. After repeated studies, multiple improvement tests, and verification of various processing methods, the inventor finally obtained the best processing method and determined a typical preparation and its preparation method.
本发明的目的是提供一种用膨化方法制出的口味很好,服用方便的速溶阿胶粉,阿胶含量100%,补血效果令人非常满意。The object of the present invention is to provide a kind of instant donkey-hide gelatin powder prepared by puffing method, which has good taste and is convenient to take. The donkey-hide gelatin content is 100%, and the effect of nourishing blood is very satisfactory.
本发明的另一个目的是提供一种常用速溶阿胶粉冲剂。Another object of the present invention is to provide a kind of commonly used instant donkey-hide gelatin powder electuary.
本发明的第三个目的是提供一种以膨化阿胶粉为君药对贫血有特效的中药组合物。The third object of the present invention is to provide a traditional Chinese medicine composition which uses puffed donkey-hide gelatin powder as the main drug and has special effects on anemia.
本发明的目的是由以下具体方案实现的。The object of the present invention is achieved by the following specific solutions.
一种速溶阿胶粉是由纯阿胶原料粉碎后,加入螺杆挤压膨化机中,在温度120-150℃、转速200-400/分的条件下膨化,再经过粉碎即成速溶阿胶粉。An instant donkey-hide gelatin powder is pulverized from pure donkey-hide gelatin raw materials, added to a screw extruder, extruded at a temperature of 120-150°C and a rotating speed of 200-400/min, and then pulverized into an instant donkey-hide gelatin powder.
一种速溶阿胶粉冲剂各组分用量为在下述重量份范围都具有较好效果:The consumption of each component of a kind of instant donkey-hide gelatin powder electuary all has better effect in following weight part scope:
阿胶粉50-100份、植脂末1~50份,甜味剂0.1~1份。50-100 parts of donkey-hide gelatin powder, 1-50 parts of non-dairy creamer, 0.1-1 part of sweetener.
优选为:阿胶粉50份、植脂末49份,甜味剂1份。Preferably: 50 parts of donkey-hide gelatin powder, 49 parts of non-dairy creamer, and 1 part of sweetener.
一种速溶阿胶粉冲剂的制备方法,具体步骤如下:A kind of preparation method of instant donkey-hide gelatin powder granule, concrete steps are as follows:
①将上述方法加工出来的膨化阿胶粉按组分重量称出;①Weigh the puffed donkey-hide gelatin powder processed by the above method by component weight;
②再按组分重量称出植脂末、甜味剂,混合均匀,剂量包装即可。②Weigh out the non-dairy creamer and sweetener according to the weight of the components, mix them evenly, and pack them in doses.
一种以膨化阿胶粉为君药对贫血有特效的中药组合物,各组分用量为在下述重量份范围都具有较好效果:A traditional Chinese medicine composition with puffed donkey-hide gelatin powder as the main drug which has special effects on anemia, and the dosage of each component has a good effect in the following parts by weight:
膨化阿胶粉2-4份、熟地3-5份、当归3-5份、白芍3-5份。2-4 parts of puffed donkey-hide gelatin powder, 3-5 parts of rehmannia glutinosa, 3-5 parts of angelica, 3-5 parts of white peony root.
优选为:阿胶粉4份、熟地5份、当归4份、白芍5份。Preferably: 4 parts of donkey-hide gelatin powder, 5 parts of rehmannia glutinosa, 4 parts of angelica, 5 parts of white peony root.
一种以膨化阿胶粉为君药对贫血有特效的中药组合物,各组分用量为在下述重量份范围都具有较好效果:A traditional Chinese medicine composition with puffed donkey-hide gelatin powder as the main drug which has special effects on anemia, and the dosage of each component has a good effect in the following parts by weight:
膨化阿胶粉2-4份、熟地3-5份、当归3-5份、白芍3-5份。2-4 parts of puffed donkey-hide gelatin powder, 3-5 parts of rehmannia glutinosa, 3-5 parts of angelica, 3-5 parts of white peony root.
优选为:阿胶粉4份、熟地5份、当归4份、白芍5份。Preferably: 4 parts of donkey-hide gelatin powder, 5 parts of rehmannia glutinosa, 4 parts of angelica, 5 parts of white peony root.
膨化阿胶粉为君药对贫血有特效的中药组合物的制备方法,具体步骤如下:The preparation method of puffed donkey-hide gelatin powder is a traditional Chinese medicine composition that Junyao has special effects on anemia, and the specific steps are as follows:
①将膨化阿胶粉按组分重量称出;① Weigh out the puffed donkey-hide gelatin powder according to the weight of the components;
②按组分重量称出熟地、当归、白芍混合;加入振动研磨机粉碎至细胞破壁成微粉;② Mix rehmannia glutinosa, angelica, and white peony root according to the weight of the components; add a vibrating grinder to pulverize until the cells are broken into fine powder;
③将膨化阿胶粉与破壁的熟地、当归、白芍微粉混合,定量分装即可。③ Mix the puffed donkey-hide gelatin powder with the broken rehmannia glutinosa, angelica, and white peony powder, and then pack them quantitatively.
本发明产品由于阿胶被膨化后处理成粉,其产品阿胶含量100%,口味变好,容易吸收,经检测符合食品要求可以直接服用,补血效果明显;设计的膨化速溶阿胶粉冲剂口味更好,老人、儿童乐意服用,尤其更受广大妇女欢迎;以膨化阿胶粉为君药对贫血有特效的中药组合物,经试验对治疗失血及造血功能障碍,如:咯血、呕血、便血,月经过多、产褥出血、外伤等疗效很明显,深受广大患者欢迎。Because the donkey-hide gelatin is puffed and processed into powder, the product of the present invention has a 100% donkey-hide gelatin content, better taste, and is easy to absorb. It can be taken directly after testing and meets the food requirements, and the effect of enriching blood is obvious; the designed puffed instant donkey-hide gelatin powder granule tastes better , the elderly and children are willing to take it, especially more popular with women; the traditional Chinese medicine composition with puffed donkey-hide gelatin powder as the main drug has special effects on anemia, and has been tested for the treatment of blood loss and hematopoietic dysfunction, such as: hemoptysis, hematemesis, blood in the stool, menstruation Too much, puerperal hemorrhage, trauma and other curative effects are obvious, welcomed by the majority of patients.
[具体实施方式][Detailed ways]
以膨化阿胶粉为君药对贫血有特效的中药组合物临床观察情况如下:The clinical observation of the traditional Chinese medicine composition with special effects on anemia with puffed donkey-hide gelatin powder as the main drug is as follows:
简介:贫血是常见病、多发病,多见于各种失血及造血功能障碍,如:咯血、呕血、便血,月经过多、产褥出血、外伤等。造血功能障碍如再生障碍性贫血、白血病、骨髓瘤等。中药补血方剂很多,但效果慢,服用不方便,本膨化阿胶粉制剂采用传统中药秘方,经超微粉碎,服用方便、节约药材、疗效增加,迅速改善造血功能,纠正贫血。Introduction: Anemia is a common and frequently-occurring disease. It is more common in various blood loss and hematopoietic dysfunction, such as: hemoptysis, hematemesis, blood in the stool, menorrhagia, puerperal hemorrhage, trauma, etc. Hematopoietic dysfunction such as aplastic anemia, leukemia, myeloma, etc. There are many traditional Chinese medicine blood-tonifying prescriptions, but the effect is slow and inconvenient to take. The puffed donkey-hide gelatin powder preparation adopts the traditional Chinese medicine secret recipe, which is ultrafinely pulverized, easy to take, saves medicinal materials, increases curative effect, rapidly improves hematopoietic function, and corrects anemia.
组分药原料为:The raw materials of component medicine are:
膨化阿胶粉:性甘、平,入肾、肝、肺经,有补血止血、滋阴润燥作用,用于血虚出血,吐血便血等;Puffed donkey-hide gelatin powder: sweet and flat in nature, enters the kidney, liver, and lung meridians, has the effects of nourishing blood and stopping bleeding, nourishing yin and moistening dryness, and is used for blood deficiency and bleeding, vomiting blood, blood in the stool, etc.;
当归:性甘、辛温、入心、肝、脾经,用于补血调经,活血散瘀,用于血虚月经不调;Angelica: sweet in nature, pungent and warm, entering the heart, liver, and spleen meridian, used for nourishing blood and regulating menstruation, promoting blood circulation and dispelling blood stasis, and used for blood deficiency and irregular menstruation;
熟地:性甘、微温,入心、肝、肾经,用于滋补肝肾,养血调经,用于久病血虚肝肾不足;Rehmannia glutinosa: sweet and slightly warm in nature, enters the heart, liver, and kidney meridian, used for nourishing liver and kidney, nourishing blood and regulating menstruation, and used for chronic disease blood deficiency and liver and kidney deficiency;
白芍:苦、酸、微寒,入肝经,用于血虚月经不调等,Radix Paeoniae Alba: Bitter, sour, slightly cold, enters the liver meridian, used for blood deficiency and irregular menstruation, etc.
临床观察:病例选择:各种原因引起的贫血60例,症状均有失血史,伴有头痛、头晕、乏力、面色苍白等症。60例中男性20例,女性40例,年龄18-50岁。病史6月-3年,Hb7g/L以下、RBC310万/立方毫米以下。该组病例一律仃服其他补血生血药物。Clinical Observation: Case selection: 60 cases of anemia caused by various reasons, the symptoms all had a history of blood loss, accompanied by headache, dizziness, fatigue, pale complexion and other symptoms. Among the 60 cases, there were 20 males and 40 females, aged 18-50 years. Medical history of 6 months to 3 years, Hb7g/L below, RBC3.1 million/cubic millimeter below. All patients in this group took other blood-enriching and blood-generating drugs.
将以上方法制成的药物超微粉药分装为:9g/包,每日2次冲服,30天为一疗程,复查Hb及RBC,共治疗3个疗程。The medicine superfine powder medicine made by the above method is subpackaged into: 9g/bag, taken after mixing with water 2 times a day, 30 days is a course of treatment, check Hb and RBC, treat 3 courses of treatment altogether.
结果:60例病人经服用1月后自觉症状好转或消失,Hb及RBC有所提高,3月后症状全部消失,Hb及RBC恢复正常。Results: The symptoms of 60 patients improved or disappeared after taking the drug for 1 month, and the Hb and RBC increased. The symptoms disappeared after 3 months, and the Hb and RBC returned to normal.
讨论:贫血是常见病、多发病,传统补血铁剂及叶酸口服后对胃肠有刺激,引起恶心、食欲减退,不易坚持,中药补血方剂太大,煎煮费时费力,饮用困难,疗效欠佳,本阿胶组合物制剂无沉渣,服用方便宜吸收,大大提高了疗效,深受患者欢迎。Discussion: Anemia is a common and frequently-occurring disease. Traditional blood-enriching iron supplements and folic acid can irritate the gastrointestinal tract after oral administration, causing nausea and loss of appetite. , the donkey-hide gelatin composition preparation has no sediment, it is cheap to absorb when taken, greatly improves the curative effect, and is very popular among patients.
典型病例如下:Typical cases are as follows:
病例1:王志国,男、26岁,因胃溃疡合并出血,查Hb8.5g/L、RBC284万/立方毫米,经服用本制剂1月后症状消失,3月后Hb及RBC正常。Case 1: Wang Zhiguo, male, 26 years old, due to gastric ulcer and bleeding, Hb8.5g/L, RBC2.84 million/mm3, symptoms disappeared after taking this preparation for 1 month, and Hb and RBC were normal after 3 months.
例2:孙玉英,女、42岁,因子宫肌瘤引起月经过多,经常头晕乏力,查Hb7.4G/L,RBC262万/立方毫米,经服用本制剂1月后症状好转,3月后Hb及RBC恢复正常。Example 2: Sun Yuying, female, 42 years old, had menorrhagia caused by uterine fibroids, often dizzy and weak. Check Hb7.4G/L, RBC2.62 million/cubic millimeter. Hb and RBC returned to normal.
例3:马荣,女、18岁,因再生障碍性贫血经常乏力,头晕,查Hb5.8G/L、RBC234万/立方毫米,经服用该制剂3月后自觉症状全部消失,血象正常。Example 3: Ma Rong, female, 18 years old, was often fatigued and dizzy due to aplastic anemia, her Hb5.8G/L and RBC2.
例4:张跃东,男、50岁,因溃疡性结肠炎便血后出现头晕、乏力,查Hb5.4G/L、RBC215万/立方毫米,经口服本制剂3月后症状明显好转,复查血象正常。Example 4: Zhang Yuedong, male, 50 years old, had dizziness and fatigue after hematochezia due to ulcerative colitis. His Hb5.4G/L and RBC2150,000/mm3 were checked. After taking this preparation for 3 months, his symptoms improved obviously, and his blood picture was normal again.
例5:桑云,女、23岁,因胃炎引起缺铁性贫血,Hb5.6G/L、RBC263万/立方毫米,自觉乏力、纳差、头晕,服用本制剂3月后症状消退,血象正常。Example 5: Sang Yun, female, 23 years old, iron deficiency anemia caused by gastritis, Hb5.6G/L, RBC2.63 million/mm3, felt fatigue, poor appetite, dizziness, after taking this preparation for 3 months, the symptoms subsided and the blood picture was normal .
例6:刘东海,男、48岁,因肺癌引起咯血,Hb4.5G/L、RBC186万/立方毫米,经服用本制剂3月后,病情隐定,面色红润,咯血仃止,Hb及RBC接近正常。Example 6: Liu Donghai, male, 48 years old, hemoptysis caused by lung cancer, Hb4.5G/L, RBC1.86 million/mm3, after taking this preparation for 3 months, his condition stabilized, his complexion was rosy, hemoptysis stopped, Hb and RBC were close to normal.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010035262A3 (en) * | 2008-09-25 | 2010-05-27 | Life Biotech Medical Research Ltd | Herbal formulations |
| CN101912417A (en) * | 2010-08-23 | 2010-12-15 | 陕西科技大学 | A kind of instant donkey-hide gelatin granules and preparation method thereof |
| CN103598606A (en) * | 2013-10-30 | 2014-02-26 | 辽宁宏宇生物科技有限公司 | Instantly soluble deer glue radix astragali powder and preparation method thereof |
| CN109480032A (en) * | 2019-01-17 | 2019-03-19 | 陈广芬 | A kind of instant ass-hide gelatin ground coffee and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1025412C (en) * | 1988-07-22 | 1994-07-13 | 赵会祥 | Powder quick dissolving donkey-hide gelatin |
| CN1079148A (en) * | 1992-05-27 | 1993-12-08 | 山东平阴阿胶厂 | Process for preparing instant donkey-hide gelatin |
| CN1092656A (en) * | 1994-01-14 | 1994-09-28 | 山东省东阿阿胶(集团)股份有限公司 | Donkey-hide gelatin beverage and preparation method thereof |
| CN1803151A (en) * | 2005-01-14 | 2006-07-19 | 沈佳寅 | Instant donkey-hide gelatin |
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2007
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010035262A3 (en) * | 2008-09-25 | 2010-05-27 | Life Biotech Medical Research Ltd | Herbal formulations |
| US8574636B2 (en) | 2008-09-25 | 2013-11-05 | Lifebiotic Medical Research Ltd | Herbal formulations |
| US9370543B2 (en) | 2008-09-25 | 2016-06-21 | Lifebiotic Medical Research Ltd | Herbal formulations |
| US10172904B2 (en) | 2008-09-25 | 2019-01-08 | Lifebiotic Medical Research Ltd | Herbal formulations |
| CN101912417A (en) * | 2010-08-23 | 2010-12-15 | 陕西科技大学 | A kind of instant donkey-hide gelatin granules and preparation method thereof |
| CN101912417B (en) * | 2010-08-23 | 2012-07-25 | 陕西科技大学 | Instant donkey-hide gelatin granules and preparation method thereof |
| CN103598606A (en) * | 2013-10-30 | 2014-02-26 | 辽宁宏宇生物科技有限公司 | Instantly soluble deer glue radix astragali powder and preparation method thereof |
| CN109480032A (en) * | 2019-01-17 | 2019-03-19 | 陈广芬 | A kind of instant ass-hide gelatin ground coffee and preparation method thereof |
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