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CN100562336C - Huoxue Dan and its preparation method - Google Patents

Huoxue Dan and its preparation method Download PDF

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CN100562336C
CN100562336C CNB2006100476564A CN200610047656A CN100562336C CN 100562336 C CN100562336 C CN 100562336C CN B2006100476564 A CNB2006100476564 A CN B2006100476564A CN 200610047656 A CN200610047656 A CN 200610047656A CN 100562336 C CN100562336 C CN 100562336C
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CN1927371A (en
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张贵
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Abstract

The present invention relates to a kind of is the medicine and preparation method thereof of the treatment traumatic injury made of raw material and fracture tendon breaking with the vegetable Chinese herbal medicine.It is the medicament of being made by the following weight proportion raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae=0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5.The present invention is a pure Chinese medicinal preparation, has no side effect and untoward reaction, and any artificial fixed form such as do not need train wheel bridge, planter cast, tie up has alleviated patient's misery and financial burden.Healing stage is short, instant effect.Take this medicine and got final product obvious pain relieving in 20 minutes, the clinical practice proof is compared with traditional therapy can shorten the course of treatment 1/2nd.The present invention is on the basis of secret recipe handed down in the family, and surplus the clinical practice 40 year, the consistent curative effect that reflects of patient is very good again, and drug effect is rapid.

Description

活血丹及其制备方法 Huoxue Dan and its preparation method

技术领域 technical field

本发明涉及一种治疗跌打损伤、骨折、红肿热痛的药物组合物,特别是涉及一种以植物中草药为原料制成的治疗跌打损伤及骨折筋断的药物及其制备方法。The invention relates to a pharmaceutical composition for treating bruises, fractures, redness, swelling and heat pain, in particular to a medicine for treating bruises, bone fractures and broken tendons made from plant Chinese herbal medicines and a preparation method thereof.

背景技术 Background technique

现有骨伤病的治疗方法一般采用人工接骨、手术接骨等方法。采用借助X光机或其它手段,将骨折部复位后,利用夹板、石膏绷带或手术钢板固定,服消炎药或治疗跌打损伤药,静养三个月左右,但实施正骨复位后,由于利用外敷用药的渗透作用,使其疗效慢,以及患者自身因素多方面的原因,易使骨折部位出现不同程度的重叠移位,致使部位肿胀疼痛,造成伸屈功能减弱或丧失,给患者带来极大痛苦。如果采用手术钢板固定,在骨折愈合后,还需进行二次手术,取出钢板和固定钢钉,给患者造成的痛苦就可想而知了,并且在骨骼上又留下人为造成的螺钉孔,造成骨折的骨头再次修复,同时这又有感染骨髓炎的可能。目前治疗骨折的药物虽然很多,但软坚和止痛效果不好,接骨愈合时间长,病人痛苦大。The treatment method of existing bone injury generally adopts methods such as artificial bone setting, operation bone setting. With the help of X-ray machine or other means, after the fracture is reduced, it is fixed with a splint, plaster bandage or surgical plate, and it takes anti-inflammatory drugs or drugs for the treatment of bruises, and it rests for about three months. The infiltration effect of the drug makes the curative effect slow, and the patient's own factors may cause different degrees of overlapping and displacement of the fracture site, resulting in swelling and pain at the site, resulting in weakened or lost flexion and extension functions, which bring great harm to the patient. pain. If the surgical plate is used for fixation, after the fracture heals, a second operation is required to remove the plate and fixation nails. The pain caused to the patient can be imagined, and artificial screw holes are left on the bone. The bone that caused the fracture repairs again, and at the same time there is the possibility of infection with osteomyelitis. Although there are many medicines for the treatment of fractures at present, the softening and pain-relieving effects are not good, the bone healing time is long, and the patient suffers a lot.

发明内容 Contents of the invention

本发明的目的是针对上述问题而提供的一种治疗跌打损伤、骨折筋断、红肿热痛的活血丹及其制备方法,本发明具有愈合期短、见效快、无毒副作用与不良反应,治疗效果显著,成本低等特点,对跌打损伤、骨折筋断、红肿热痛、有很好的疗效。而且能够活血散瘀、消肿止痛、舒筋活络。The object of the present invention is to provide a kind of Huoxue Dan for the treatment of bruises, broken bones, redness, heat pain and preparation method thereof in view of the above problems. The present invention has short healing period, quick effect, no toxic side effects and adverse reactions, The treatment effect is remarkable, the cost is low, etc., and it has a good curative effect on bruises, fractures, broken tendons, redness, swelling, heat and pain. Moreover, it can promote blood circulation and dissipate blood stasis, reduce swelling and relieve pain, relax muscles and activate collaterals.

为了实现本发明的目的,本发明采用的技术方案是:In order to realize the purpose of the present invention, the technical scheme adopted in the present invention is:

活血丹,它是由下述重量配比的原料制成的药剂:秦艽∶续断∶红花∶杜仲∶肉桂∶三七∶甘草∶桃仁∶姜黄=0.5-1.5∶0.5-1.50.5-1.5∶0.5-1.5∶0.5-1.5∶0.5-1.5∶0.5-1.5∶0.5-1.5∶0.5-1.5。Huoxue Dan, which is a medicament made from the raw materials in the following weight ratio: Gentiana: Dipsacus: Safflower: Eucommia: Cinnamon: Panax notoginseng: Licorice: Peach kernel: Turmeric=0.5-1.5: 0.5-1.50.5-1.5 :0.5-1.5:0.5-1.5:0.5-1.5:0.5-1.5:0.5-1.5:0.5-1.5.

其中各原料的重量配比是:秦艽∶续断∶红花∶杜仲∶肉桂∶三七∶甘草∶桃仁∶姜黄=0.8-1.2∶0.8-1.2∶0.8-1.2∶0.8-1.2∶0.8-1.2∶0.8-1.2∶0.8-1.2∶0.8-1.2∶0.8-1.2。Wherein the weight ratio of each raw material is: Gentiana: Dipsacus: Safflower: Eucommia: Cinnamon: Panax notoginseng: Licorice: Peach kernel: Turmeric=0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2:0.8-1.2:0.8-1.2:0.8-1.2.

其中各原料的重量配比是:秦艽∶续断∶红花∶杜仲∶肉桂∶三七∶甘草∶桃仁∶姜黄=1∶1∶1∶1∶1∶1∶1∶1∶1。Wherein the weight proportion of each raw material is: Gentiana chinensis: Dipsacus: safflower: Eucommia: cinnamon: Panax notoginseng: licorice: peach kernel: turmeric=1:1:1:1:1:1:1:1:1.

活血丹的制备方法,它是由下述重量配比的原料制成的药剂:秦艽∶续断∶红花∶杜仲∶肉桂∶三七∶甘草∶桃仁∶姜黄=0.5-1.5∶0.5-1.5∶0.5-15∶0.5-1.5∶0.5-1.5∶0.5-1.5∶0.5-1.5∶0.5-1.5∶0.5-1.5;The preparation method of Huoxuedan is a medicament made of the following raw materials in weight ratio: Gentiana chinensis: Dipsacus safflower: Eucommia ulmoides: cinnamon: Panax notoginseng: licorice: peach kernel: turmeric=0.5-1.5: 0.5-1.5: 0.5-15: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5;

其制备方法包括以下步骤:Its preparation method comprises the following steps:

1、将上述各单味药经挑选、清洗、干燥后用粉碎机粉碎,过120目筛;1. After selecting, cleaning and drying the above-mentioned single herbs, pulverize them with a pulverizer and pass through a 120-mesh sieve;

2、按上述比例取粉碎后的各单味药充分混匀,分装成袋。2. Take the pulverized single herbs according to the above ratio, mix them thoroughly, and pack them into bags.

本发明所具有的优点与效果是:Advantage and effect that the present invention has are:

1、本发明为纯中药制剂,无毒副作用与不良反应,不需要上夹板、打石膏、捆扎等任何人工固定方式,减轻了病人的痛苦,同时也减轻了病人的经济负担。1. The present invention is a pure traditional Chinese medicine preparation, without toxic side effects and adverse reactions, and does not need any artificial fixation methods such as splinting, plastering, and binding, which reduces the pain of the patient and also reduces the economic burden of the patient.

2、本发明愈合期短、见效快。服本药20分钟即可明显止痛,临床实践证明与传统治疗方法相比可缩短疗程二分之一。2. The present invention has short healing period and quick effect. Taking this medicine for 20 minutes can obviously relieve pain, and clinical practice proves that compared with traditional treatment methods, the course of treatment can be shortened by one-half.

3、本发明是在家传秘方的基础上,又经临床应用四十余年,患者一致反映疗效甚好,药效迅速,总有效率99,显效率96%。3. The present invention is based on the secret recipe handed down from family, and has been clinically used for more than 40 years. Patients consistently report that the curative effect is very good, the drug effect is rapid, the total effective rate is 99%, and the marked rate is 96%.

4、本发明对跌打损伤、骨折筋断、红肿热痛有很好的疗效。而且能够活血散瘀、消肿止痛、舒筋活络。4. The present invention has a good curative effect on bruises, bone fractures, redness, swelling and heat pain. Moreover, it can promote blood circulation and dissipate blood stasis, reduce swelling and relieve pain, relax muscles and activate collaterals.

为表明本发明对治疗骨折的疗效,本发明经100例系统临床观察,又选择病史、病情、年龄、性别相当的100例对照组,均为住院治疗,治疗前均未用过任何接骨药。将骨伤病人随机分为服用本发明“活血丹”组(以下简称治疗组)和“麝香接骨胶囊”组(以下简称对照组),治疗组100例,年龄最小8岁,年龄最大60岁,平均年龄50岁,男女比例4∶1;对照组100例,年龄最小8岁,年龄最大60岁,平均年龄55岁,男女比例4∶1,均为住院治疗,治疗前均未用过任何接骨药物。用药:口服活血丹,用黄酒或温开水送服,成人每日三次,每次2-3克,儿童减半。用药期间忌服生葱、生姜、生蒜、大萝卜,孕妇忌服、胃病患者慎用。麝香接骨胶囊成人每服5粒,儿童每服2粒,每日3次。连续用药20-40天,随时观察治疗结果,患部肿胀消退时间,每7日摄片一次,检查对位和骨痂生长情况及患肢功能恢复时间。疗效判断标准(1)显效:临床用药时间比同类骨折愈合时间提前1/3~1/4,达到临床愈合标准者。(2)有效:临床上用药时间比同类骨折愈合时间提前1/4~1/5,达到临床愈合标准者。(3)无效:临床上用药时间与同类骨折正常愈合时间相同。,详情见下表:In order to show the curative effect of the present invention on the treatment of fractures, the present invention selected 100 matched groups with medical history, condition, age and sex through 100 systematic clinical observations, all of whom were hospitalized, and had never used any osteosynthetic drugs before treatment. Orthopedic patients are randomly divided into taking "Huoxue Pill" group of the present invention (hereinafter referred to as the treatment group) and "Musk Joint Bone Capsule" group (hereinafter referred to as the control group), 100 cases in the treatment group, the youngest is 8 years old, and the oldest is 60 years old. The average age is 50 years old, the male to female ratio is 4:1; the control group is 100 cases, the youngest is 8 years old, the oldest is 60 years old, the average age is 55 years old, and the male to female ratio is 4:1. drug. Medication: Take Huoxue Dan orally, take it with rice wine or warm water, three times a day for adults, 2-3 grams each time, half for children. Do not take raw onion, ginger, raw garlic, and radish during the medication period. Pregnant women should not take it, and patients with stomach problems should use it with caution. Musk bone capsules are 5 capsules for adults and 2 capsules for children, 3 times a day. Continuous medication for 20-40 days, observe the treatment results at any time, the time of swelling subsidence of the affected area, and take a film every 7 days to check the alignment and callus growth and the recovery time of the affected limb function. Efficacy Judgment Criteria (1) Significantly effective: the time of clinical application is 1/3-1/4 earlier than the healing time of similar fractures, and those who meet the clinical healing standard. (2) Effective: the time of clinical application of the drug is 1/4 to 1/5 earlier than the healing time of similar fractures, and those who have reached the clinical healing standard. (3) Ineffective: The clinical medication time is the same as the normal healing time of similar fractures. , see the table below for details:

表一治疗组与对照组临床诸症状疗效比较Table 1 Comparison of curative effects of clinical symptoms between the treatment group and the control group

Figure C20061004765600061
Figure C20061004765600061

表二治疗组与对照组疗效比较Table 2 Comparison of curative effect between the treatment group and the control group

Figure C20061004765600062
Figure C20061004765600062

结论:in conclusion:

临床观察结果证明,口服本发明活血丹对治疗骨折具有很好的治疗作用,无毒副作用,本发明活血丹对跌打损伤、骨折筋断、红肿热痛、具有很好的疗效,而且活血散瘀、消肿止痛、舒筋活络,是一种疗效确切的纯中药制剂。The results of clinical observation prove that oral administration of Huoxue Dan of the present invention has a good therapeutic effect on the treatment of fractures, without toxic and side effects. Blood stasis, reducing swelling and relieving pain, relaxing tendons and activating collaterals, is a pure Chinese medicine preparation with definite curative effect.

下面是一些具体的病例:The following are some specific cases:

患者姓名:王振红。性别:男。年龄:8岁。于2001年11月2日由床上跌下,造成右肘部肱骨下头粉碎性骨折,在其它医院治疗无效的情况下于11月下旬来张贵骨伤科门诊治疗。当时来门诊时患者右肘肿胀,夹板固定,自带片示右肱踝颈部粉碎性骨折。肘关节功能障碍。活动受限。内服活血丹,按成人之半量服药,同时结合功能锻炼。一个月基本达到骨折愈合,功能活动接近正常。Patient name: Wang Zhenhong. Sex: Male. Age: 8 years old. On November 2, 2001, he fell from the bed, resulting in a comminuted fracture of the lower head of the humerus at the right elbow. He came to Zhanggui Orthopedics and Traumatology Clinic in late November for treatment when other hospitals failed to treat him. When he came to the clinic, the patient's right elbow was swollen and fixed with a splint. The radiograph showed a comminuted fracture of the right humerus, ankle and neck. Elbow dysfunction. Activities are restricted. Take Huoxue Dan orally, take half the dose of an adult, and combine it with functional exercise. Fracture healing was basically achieved within one month, and functional activities were close to normal.

患者姓名:甘风琴。性别:女。年龄:60岁。2005年2月摔伤右腕关节。当时去其它医院确诊为右桡骨颈骨折。手法复位,夹板固定,内服琥珀丸,治疗3个月后拍片发现骨折处对位欠佳,右腕关节不能外翻。右手不能握。手指伸不直,肿胀疼痛。2005年6月来张贵骨伤科诊所治疗,内服活血丹,并配合手法按摩,治疗半个月右手能梳头、洗脸、吃饭,活动功能基本恢复正常。Patient name: Gan Fengqin. Gender: Female. Age: 60 years old. In February 2005, he broke his right wrist joint. At that time, I went to another hospital and was diagnosed with right radial neck fracture. Manipulative reduction, splint fixation, and oral administration of amber pills. After 3 months of treatment, it was found that the alignment of the fracture was not good, and the right wrist joint could not be everted. Can't hold right hand. Unable to straighten fingers, swelling and pain. In June 2005, he came to Zhanggui Orthopedic Clinic for treatment. He took Huoxue Dan orally and combined with manual massage. After half a month of treatment, his right hand was able to comb hair, wash face, and eat, and his activities and functions basically returned to normal.

具体实施方式 Detailed ways

实施例1:Example 1:

活血丹,按下述重量配比取下述原料:秦艽∶续断∶红花∶杜仲∶肉桂∶三七∶甘草∶桃仁=0.5∶1.5∶1.5∶1.5∶1.5∶1.5∶1.5∶1.5。Huoxue Dan, the following raw materials are obtained according to the following weight ratio: Gentiana: Dipsacus: Safflower: Eucommia: Cinnamon: Panax notoginseng: Licorice: Peach Kernel = 0.5: 1.5: 1.5: 1.5: 1.5: 1.5: 1.5: 1.5.

其制备方法包括以下步骤:Its preparation method comprises the following steps:

1、将上述各单味药经挑选、清洗、干燥后筛去粉尘与杂质,再用粉碎机粉碎,过120目筛;1. After selecting, cleaning and drying the above-mentioned single herbs, sieve to remove dust and impurities, then pulverize them with a pulverizer, and pass through a 120-mesh sieve;

2、按上述比例取粉碎后的各单味药进行充分混匀后得中药原粉,将中药原粉分装成每袋2.5克。2. Take the pulverized single herbs according to the above proportions and fully mix them to obtain the original powder of traditional Chinese medicine, and pack the original powder of traditional Chinese medicine into 2.5 grams per bag.

实施例2:Example 2:

活血丹,按下述重量配比取下述原料:秦艽∶续断∶红花∶杜仲∶肉桂∶三七∶甘草∶桃仁=1.5∶0.5∶0.5∶0.5∶0.5∶0.5∶0.5∶0.5。Huoxue Dan, the following raw materials are taken according to the following weight ratios: Gentiana: Dipsacus: Safflower: Eucommia: Cinnamon: Panax notoginseng: Licorice: Peach Kernel = 1.5: 0.5: 0.5: 0.5: 0.5: 0.5: 0.5: 0.5.

其制备方法同实施例1。Its preparation method is with embodiment 1.

实施例3:Example 3:

活血丹,按下述重量配比取下述原料:秦艽∶续断∶红花∶杜仲∶肉桂∶三七∶甘草∶桃仁=0.8∶1.21.2∶1.2∶1.2∶1.2∶1.2∶1.2。Huoxue Dan, the following raw materials are taken according to the following weight ratio: Gentiana: Dipsacus: Safflower: Eucommia: Cinnamon: Panax notoginseng: Licorice: Peach Kernel = 0.8: 1.21.2: 1.2: 1.2: 1.2: 1.2: 1.2.

其制备方法同实施例1。Its preparation method is with embodiment 1.

实施例4:Example 4:

活血丹,按下述重量配比取下述原料:秦艽∶续断∶红花∶杜仲∶肉桂∶三七∶甘草∶桃仁=1.2∶0.8∶0.8∶0.8∶0.8∶0.8∶0.8∶0.8。Huoxue Dan, the following raw materials are taken according to the following weight ratio: Gentiana: Dipsacus: Safflower: Eucommia: Cinnamon: Panax notoginseng: Licorice: Peach Kernel = 1.2: 0.8: 0.8: 0.8: 0.8: 0.8: 0.8: 0.8.

其制备方法同实施例1。Its preparation method is with embodiment 1.

实施例5:Example 5:

活血丹,按下述重量配比取下述原料:秦艽∶续断∶红花∶杜仲∶肉桂∶三七∶甘草∶桃仁=1∶1∶1∶1∶1∶1∶1∶1。Huoxue Dan, the following raw materials are taken according to the following weight ratio: Gentiana: Dipsacus: Safflower: Eucommia: Cinnamon: Panax notoginseng: Licorice: Peach kernel = 1:1:1:1:1:1:1:1.

其制备方法同实施例1。Its preparation method is with embodiment 1.

Claims (4)

1, HUOXUEDAN is characterized in that it is the medicament of being made by the following weight proportion raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5.
2, HUOXUEDAN according to claim 1 is characterized in that wherein the weight proportion of each raw material is: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2 0.8-1.2.
3, HUOXUEDAN according to claim 1 is characterized in that wherein the weight proportion of each raw material is: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=1: 1: 1: 1: 1: 1: 1: 1: 1.
4, the preparation method of HUOXUEDAN is characterized in that described HUOXUEDAN is the medicament of being made by the following weight proportion raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5;
Its preparation method may further comprise the steps:
1, above-mentioned each single medicinal material is pulverized with pulverizer, crossed 120 mesh sieves;
2, get the abundant mixing of each single medicinal material after the pulverizing according to the above ratio, be distributed into bag.
CNB2006100476564A 2006-09-07 2006-09-07 Huoxue Dan and its preparation method Expired - Fee Related CN100562336C (en)

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CN101862401B (en) * 2010-06-18 2011-08-17 杨孟良 Chinese medicinal boiled packing bag and method for manufacturing same
MX339101B (en) * 2011-03-11 2016-05-11 Jose Arturo Castañeda Miranda Herbal polypharmaceutical for preventing and treating atherosclerosis.
CN105055505A (en) * 2015-08-27 2015-11-18 黄鸿新 Medicinal liquor for treating traumatic injuries
CN110063985A (en) * 2019-06-14 2019-07-30 张旭洪 A kind of thermal pack formula with activating microcirculation and removing stasis medicinal function

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