CN109793983A - Transdermal delivery device is targeted outside domestic electric heating physical therapy - Google Patents
Transdermal delivery device is targeted outside domestic electric heating physical therapy Download PDFInfo
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- CN109793983A CN109793983A CN201910098567.XA CN201910098567A CN109793983A CN 109793983 A CN109793983 A CN 109793983A CN 201910098567 A CN201910098567 A CN 201910098567A CN 109793983 A CN109793983 A CN 109793983A
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Abstract
The present invention provides transdermal delivery device is targeted outside a kind of domestic electric heating physical therapy, including electric heating layer (1), anti-leakage layer (3) and dipping medicament layer (4), anti-leakage layer (3) setting is between electric heating layer (1) and dipping medicament layer (4), the electric heating layer (1) wraps up being provided with insulating layer (2) outside, and electric heating layer (1) is specifically heated using electrical heating elements.Compared with prior art, the beneficial effects of the present invention are: the present apparatus can be carrier based on domestic electric heating physical therapy protector, combination is simple and practical, overcomes the percutaneous rate of transdermal target administration, creativeness solves outer targeting cutaneous penetration Quick medicine technological difficulties.Patient oneself voluntarily adjusts temperature according to tolerance, and when administration is harmless without keenly feeling to skin, and operation very handy and safe is reliable.The dosage of cutaneous penetration can control accurate, can be efficiently applied to topical transdermal administration.The medicament categories and bioavilability that can be used for cutaneous penetration are effectively increased simultaneously.
Description
Technical field
The invention belongs to medical health apparatus technical fields, and in particular to cutaneous penetration is targeted outside a kind of domestic electric heating physical therapy
Device.
Background technique
Joint stuffiness is intended to four limbs passages through which vital energy circulates muscles contraction and does not relax suddenly, cannot be fully finished movement, joint extension dysfunction
(e.g., cervical vertebra, lumbar vertebrae, knee joint, hip joint etc.).Swelling, pain or the passages through which vital energy circulates QI-blood circulation of skeletal muscle and soft tissue are obstructed, blood
It from channels, deposits in part, symptom is more common in degenerative osteoarthritis, senescent arthritis, hypertrophiarthritis, is due to increasing
The damage of articular cartilage degeneration caused by the factors such as age, obesity, strain, wound, joint birth defect, joint deformity is closed
Save edge and subchondral bone reactive hyperplasia.Clinical manifestation is the arthralgia, tenderness, stiff, arthroncus, work slowly developed
Dynamic limited and joint deformity.Especially high level, the treatment of joint stuffiness degenerative osteoarthropathy are had reached in contemporary medical science
As a result but usually make us greatly disappointed.To find out its cause, being that articular cartilage tissue does not have any blood vessel and neuromechanism, conventional medicine
Object cannot be introduced into lesion, be difficult to play a role, however, urarthritis has mostly, pain, the talent probably only suffered from know,
Stranger can not imagine at all and can not understand.In numerous Patients ' Cognitives, Bones and joints illness can not be cured, and can only rely on drug control
System is alleviated.These side effects of pharmaceutical drugs, everybody also knows fairly well, is not added repeats herein.The pain of Bones and joints illness, is wrecked
The body and mind for being not only a people, virtually but allow the colourful life of script in the life under the table rewriting a people
Life becomes intense darkness without light gradually.
Physical therapy device in the prior art only has heating function mostly, and effectively drug cannot go directly inside affected part, with
It is undesirable as the function and effect for relieving pain and treat disease.
Summary of the invention
In order to overcome the above technical problems, the present invention provides a kind of domestic electric heating physical therapies to target transdermal delivery device outside,
Including electric heating layer, anti-leakage layer and dipping medicament layer, the anti-leakage layer setting is in electric heating layer and impregnates between medicament layer,
It is wrapped up outside the electric heating layer and is provided with insulating layer, electric heating layer specifically uses electrical heating elements to be heated.The present apparatus uses
Waist support, knee-pad, elbow support, shoulder protector, neck guard, ankle guard, bed, cushion or sweat steam the markets such as pad and sell conventional domestic electric heating physical therapy protector
For carrier.
Further, the electrical heating elements of the electric heating layer specifically use far infrared carbon fiber to be made, advanced carbon fiber
Dimension is usually as aerospace material, the novel electric heating element as heater of the invention.Far infrared carbon fiber has very high
Mechanical strength and extremely long service life, and form is soft, homogeneous heating, power stability, thermal inertia is small, it is various to be easily made
Electrical heating elements composite module adapts to the demand of various heating occasions.170 degree of nothings used below of the heating temperature that can work long hours
It deforms, burn, putrefactive phenomenon.
The preferred technical performance of the carbon fiber far-infrared and specification: carbon fiber core specification: 1K；3K；6K；9K；
12K；The adoptable specification of electric heating line footpath are as follows: φ 1.5mm, φ 2.0mm, φ 2.5mm, φ 3.0mm or φ 3.5mm；Insulating layer is set
It is set to single layer, bilayer or three layers.
Further, the insulating materials that the insulating layer uses is specially Teflon or silica gel, and the highest of insulating materials makes
It is 180 DEG C of silica gel, 200 DEG C of fluorine material with temperature；
Further, the anti-leakage layer is specially anti-heat leakage towel, and anti-heat leakage towel is gathered by 80% polyester fiber and 20%
Nylon is made.Anti- heat leakage blocking property is strong rapidly for the described towel heat transfer, and elasticity and dimensionally stable have good electricity absolutely
Edge performance is greater than domestic electric heating physical therapy protector using size.
Further, the dipping medicament layer material is specifically adopted the degreasing cotton gauze piece impregnated of medicament and is made, specially
The medical absorbent cotton Gauze for folding four layers is greater than using size and targets medical lesion affected part.The medicament of the dipping is that heat promotees
Saturating agent, specially water-solubleazone 30g, 95 DEG C of ethyl alcohol 1000g.
Compared with prior art, the beneficial effects of the present invention are: (1) present apparatus can be to carry based on domestic electric heating physical therapy protector
Body, combines simple and practical, overcomes the percutaneous rate of transdermal target administration, creativeness solve outer targeting cutaneous penetration quickly to
Medicine technological difficulties.
(2) liquid far-infrared radiation of the invention is drug from the power migrated, and directly permeates skin by aquation
30-50 millimeters of lower muscle layer is to underlying soft tissue Bones and joints.It breaches at one stroke since cartilaginous tissue does not have any blood vessel and nerve node
Structure, conventional medicine cannot be introduced into the difficult medical problem of lesion, and there is significant technical effect content to have reached qualitative change.
(3) present apparatus is capable of fixing the position of lesion, and patient oneself voluntarily adjusts temperature according to tolerance, freely slaps
Medication administration time is controlled, harmless without keenly feeling to skin when administration, operation very handy and safe is reliable, enjoys when under physical therapy
To easily comfortable marvellous pleasant sensation.This combined innovation new function and new value are applied widely, enhance the practicality and use
It is convenient, compensate for the deficiency of domestic electric heating physical therapy protector monotechnics.
(5) dosage of cutaneous penetration of the invention can control accurate, can be efficiently applied to topical transdermal administration.Have simultaneously
Effect increases the medicament categories and bioavilability that can be used for cutaneous penetration.
(6) domestic electric heating physical therapy protector combines, and for chronic ache lesion inflammatory tissue, it is thin not damage other normal tissues
Born of the same parents.It can treat a variety of local soft tissues, muscle ligament, degeneration bone and joint diseases, the supplementary therapy of systemic disease part,
Expand to tumor disease targeting thermochemotherapy.
(7) the most prominent feature of the present apparatus is: increasing the technical thermal break-through space between cells of target administration and sweat gland, pore
With the rate of sebaceous glands, therapeutic agent quickly can be transported to target area to the maximum extent makes therapeutic agent in target area concentration, therefore
Drug effect is just entirely efficiently, directly to work in lesion, really play reverse chronic pain disorders, effect reaches ideal and controls
Therapeutic effect is worth clinical expansion.
Detailed description of the invention
Fig. 1 is structural schematic diagram of the invention.
Wherein: 1 electric heating layer, 2 insulating layers, 3 anti-leakage layers, 4 dipping medicament layers.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
Embodiment:
It provides and targets transdermal delivery device outside a kind of domestic electric heating physical therapy, the present apparatus is a kind of combined application physical therapy and chemistry
The therapy that therapy combines, hereinafter referred to as: thermochemotherapy.
Transdermal delivery device, including electric heating layer 1, anti-leakage layer 3 and dipping medicament layer 4 are targeted outside domestic electric heating physical therapy,
The setting of anti-leakage layer 3 is between electric heating layer 1 and dipping medicament layer 4, and package is provided with insulating layer outside the electric heating layer 1
2, electric heating layer 1 is specifically heated using electrical heating elements.The present apparatus uses waist support, knee-pad, elbow support, shoulder protector, neck guard, shield
It is carrier that ankle, bed, cushion or sweat, which steam the markets such as pad to sell conventional domestic electric heating physical therapy protector,.
Further, the electrical heating elements of the electric heating layer 1 specifically use far infrared carbon fiber to be made, advanced carbon fiber
Dimension is usually as aerospace material, the novel electric heating element as heater of the invention.Far infrared carbon fiber has very high
Mechanical strength and extremely long service life, and form is soft, homogeneous heating, power stability, thermal inertia is small, it is various to be easily made
Electrical heating elements composite module adapts to the demand of various heating occasions.170 degree of nothings used below of the heating temperature that can work long hours
It deforms, burn, putrefactive phenomenon.
The preferred technical performance of the carbon fiber far-infrared and specification: carbon fiber core specification: 1K；3K；6K；9K；
12K；The adoptable specification of electric heating line footpath are as follows: φ 1.5mm, φ 2.0mm, φ 2.5mm, φ 3.0mm or φ 3.5mm；Insulating layer is set
It is set to single layer, bilayer or three layers.
Further, the insulating materials that the insulating layer 2 uses is specially Teflon or silica gel, and the highest of insulating materials makes
It is 180 DEG C of silica gel, 200 DEG C of fluorine material with temperature；
Further, the anti-leakage layer 3 is specially anti-heat leakage towel, and anti-heat leakage towel is gathered by 80% polyester fiber and 20%
Nylon is made.Anti- heat leakage blocking property is strong rapidly for the described towel heat transfer, and elasticity and dimensionally stable have good electricity absolutely
Edge performance is greater than domestic electric heating physical therapy protector using size.
Further, dipping 4 material of medicament layer is specifically adopted the degreasing cotton gauze piece impregnated of medicament and is made, specially
The medical absorbent cotton Gauze for folding four layers is greater than using size and targets medical lesion affected part.The medicament of the dipping is that heat promotees
Saturating agent, specially water-solubleazone 30g, 95 DEG C of ethyl alcohol 1000g.
The preparation process of hot transdermal enhancer: ethyl alcohol plus people's water-solubleazone stir evenly-stoste inspection-filling-sealing-packet
Dress-finished product detection.
Azone system oil-soluble azone is modified to become efficient water soluble product, to oleophylic, hydrophilic medicament and active constituent
There is apparent heat penetration skin that infiltration is helped to act on, makes the thermal diffusion drag reduction of drug or active additive in cuticula, therefore play
Very strong heat promotees infiltration effect.
The solubility of drug can be improved in ethyl alcohol, increases the heat conductivity of drug solvent, and another aspect ethyl alcohol can penetrate into cutin
Layer increases the distribution property of heat of solution and change drug of the drug in cuticula.
Targeting paint formulation, direct spraying affected part target drug preparation in vitro, wherein be temporary solution chemicals with
Effect a permanent cure herbal mixture object.The present invention is with Chinese traditional treatment technics: disease has sample, symptomatic treatment in acute condition, and radical treatment in chronic case is developed
Specialized application is in the present apparatus: controlling its mark with two kinds of heat penetration skins of Zhi Qiben and is administered for ideal medicament clinically.
The temporary solution chemicals are Diclofenac sodium solutions, it is characterised in that its prescription: C14H10Cl2NNaO2 30g, 95 DEG C
Ethyl alcohol 1000g.
The preparation process of targeting paint formulation: ethyl alcohol, plus people's C14H10Cl2NNaO2 dissolution stir evenly-stoste examine-it is filling-
Sealing-packaging-finished product detection.
Diclofenac is a kind of non-steroid compound, is easily absorbed by the body, the work with antipyretic analgesic and anti-inflammatory
With a line of chronic ache is clinically widely used in the cartilaginous tissue for being able to suppress the generation of inflammation, while can also repairing damage
Medication has many advantages, such as that good effect, adverse reaction is few.
The herbal mixture object that effects a permanent cure contains following prescriptions of traditional Chinese medicine: the rhizome of Chinese monkshood；Radix aconiti agrestis；Rhizoma Et Radix Notopterygii；Radix Angelicae Pubescentis；Gentianae macrophyllae；Cut into serving pieces.
Herbal mixture object technique: each 9 g of medicine-feeding, brewed 2 hours of yellow rice wine (medicine efficacy enhancing ingredient) (be conducive to thereafter technique Chinese medicine effectively at
The dissolution divided).It filters out and is fitted into wide-mouth bottle, 95 DEG C of ethyl alcohol 500g are added, seal, 30 DEG C of room temperature are impregnated 10 days, its immersion is filtered out
Filling-sealing-packaging-the product examine of liquid-is surveyed.
The stupid numbness origin cause of formation is the wet heresy of the chill of touching, blocks channels and collaterals, is obstructed through gas, generates pain, " Plain Questions numbness opinion " cloud:
" pain person, cold air mostly, there is cold therefore pain." stupid numbness cold-evil is more main, therefore the rhizome of Chinese monkshood of the big heat of Fang Zhongyong pungent-warm, radix aconiti agrestis are with heat warp
Dredging collateral, dispelling cold and removing dampness and relieve pain.The male strong Rhizoma Et Radix Notopterygii Radix Angelicae Pubescentis of smell is compounded, one is on the upper side, and one is on the lower side, and the two, which matches to lead to, to be controlled
Lower numbness;Gentianae macrophyllae is " the profit agent in expelling wind drug " compatibility application.Ethyl alcohol (being commonly called as alcohol) is the length of hundred medicines, first defends gas and goes, can be defeated
Venting QI-blood is said.Above all medicines cooperate the benefits of playing wind-dispelling, dehumidifying, cold dispelling, dredging collateral, analgesic altogether of effecting a permanent cure.
Work in combination principle is as follows:
The present invention is applied into human body affected part acupuncture point thermochemotherapy.The electrothermal component far infrared carbon of the electric heating layer 1 of drug delivery device
After fiber is powered, the carbon molecules in carbon fiber do " Brownian movement " (movement of solia particle) and claim fuel factor, are generating heat
Meanwhile the far infrared of 5.6-14 microns of wavelength of radiation " life light wave " identical as human body frequency is generated, there is stronger penetration
And radiant force, the ethyl alcohol in the cotton yarn pieces of cloth of the towel of logical anti-leakage layer and the hot transdermal enhancer of dipping generates " Brownian movement " rapidly
(movement of liquid particle), heating accelerate by acupuncture points on the human body locally it is incoming in vivo, the moisture of internal muscle layer directly penetrate skin and
The targeting paint formulation and the fusion of hot transdermal enhancer for spraying affected part, which generate aquation, makes skin hydration, and original state is far red at this time
Outside line is converted into liquid far infrared, and radiations heat energy is gradually multiplied to go directly subcutaneous muscle layer 30-50 millimeters and close to soft tissue bone
Section.The aquation that medical fluid, sweat, the fusion of gas-liquid heat generate lowers the consistency of human body skin texture, and horn cell occurs
Water content is thermally expanded up to 50%, for liquid far infrared as drug from the power migrated, the heat leak of drug can increase 5-10
Times.Under the action of thermal conduction study and thermodynamics, thermally conductive is a kind of diabatic process directly contacted.The most prominent feature of present invention work
Be: diabatic process get through channels and collaterals, active cell, improve body fluid, increase drug targeting medicine-feeding technology thermal break-through space between cells with
The rate of sweat gland, pore and sebaceous glands, therapeutic agent quickly can be transported to target area to the maximum extent makes therapeutic agent in target area
Concentration is directly worked in lesion, thus drug effect be just entirely it is efficient, the effect of really playing reverse disease, reaches ideal
Therapeutic effect.
It is polar solvent, clinical observation heat penetration skin rate determination: medical fluid, sweat, gas-liquid heat that heat, which promotees the ethyl alcohol in saturating solvent,
The aquation generated is merged, concentration of alcohol is made to quickly fall to 65 DEG C from 95 DEG C, drug fever percutaneous rate rises instead, wherein
It is maximum with saturated solution hot percutaneous rate of the drug in 65 DEG C of ethyl alcohol.It was found that when concentration of alcohol changes to 30% drug from 10%
The conductibility of solution declines, and from 30% to 60%, conductibility rises, when being greater than 65%, the conductibility of drug solution again rapidly under
Drop, but have no evident regularity.The present invention does not need to measure by cumbersome experiment, promotees saturating effect for pre- calorimetric and had both facilitated
Again economical, selection result is that use 95 DEG C of ethyl alcohol be best.
Three kinds of therapeutic modalities can be carried out using transdermal delivery device is targeted outside domestic electric heating physical therapy provided by the invention:
The first therapeutic modality combines the present apparatus in external affected part acupuncture point target spot Applied Physics therapy with chemotherapy, into
Row thermochemotherapy, the working time 45 minutes.
Second of application adjuvant treatment modality is to continue the first treatment method hot physical therapy (direct moxibustion), work
Time 15 minutes, hydrofuge, air draft, row trembled with fear, acid discharge, boosts metabolism, effect is got instant result.
The third is using adjuvant treatment modality, carbon fiber far-infrared Domestic use physiotherapeutic skin sweat steam pad, above and below human body
Position divide two panels skin pad, corresponding human necks, shoulders waist-leg position, be above the waist human necks, shoulders waist skin pad, wherein the pad upper end
Taking into 15 cm sections above pillow is cervical vertebra direct moxibustion prefecture.It is kneecap joint, arteriosclerosis and obstruction of lower limbs prefecture that lower half, which wears skin pad,.Skin
Pad uses characteristic: sleeping at night skin Moxa pad, get up in the morning steams pad as the hot moxibustion sweat of skin.
Sleeping at night skin Moxa pad, when sleep can help human body governor vessel storage savings energy, self adjustment self-regeneration
Passages through which vital energy circulates QI-blood circulation is obstructed, blood from channels or siltation in the swelling pain of part, skeletal muscle and soft tissue.Holding physiological equilibrium,
Fatigue is eliminated, restores human body physical efficiency, reach the health in sleep and preventive treatment of disease and eliminate inferior health, meets the sleep that human body head temperature warms up enough
Moxa demand.Chinese medicine acupuncture formulas or directions put into verse: it is stayed in tripe abdomen three；It is asked in the committee of back；Head term seeks Lieque；Face mouthful connected valleys is received.It illustrates in fact
Human necks, shoulders waist-leg is followed through selecting the meaning in cave.
Get up in the morning steams pad as the hot moxibustion sweat of skin, and the heat-preservation cotton of human body covering is formed a heat transfer with human interstitial
Space.Skin hot moxibustion when the heat that generates of far infrared be passed in human body by acupuncture points on the human body, sweat excretes, original state far infrared
Line is converted to liquid far infrared and goes directly in subcutaneous flesh 30-50 millimeters, and dredging governor vessel channels and collaterals is accelerated to promote blood circulation and new old
Metabolism.Traditional Chinese medicine thinks: Osteoarthritis belongs to the scope of " rheumatism ", i.e. blood stasis phlegm blockage stasis channels and collaterals are mark, with caused by liver and kidney deficiency
For this.The present invention uses first of Chinese medicine eight treating observances, diaphoresis, goes out to internal disease and evil by the way that sweating is thoroughly evil with outlet, purpose reaches
Internal organs dispeling disease and evil -- kind therapy.It is steamed using modern science and technology product sweat and pads for the steaming of human body sweat, dehumidifying, acid discharge, toxin expelling, leads to
Network, the method to tonify the liver and kidney are repaired and prevent to be led to bone network arthralgia because uric acid is excessively high.Diaphoresis dredges Conception Vessel and Governor Vessel,
Conception Vessel and Governor Vessel is logical, then eight Maitongs；Eight Maitongs, then hundred Maitong, and then constitution can be improved, strengthening the muscles and bones promotes circulation to preventive treatment of disease and disappears
Except inferior health.The hot moxibustion sweat of the present invention steams pad daily morning from using sweating be means, positive victory is evil and mark that eliminating evil is outgoing is exactly
" sweating ".A body is namely reached by getting rid of evils gas purpose in flesh to epidermis perspiration by sweating mode.
The using effect that transdermal delivery device is targeted outside domestic electric heating physical therapy is further described below by way of real case:
I specially grind Chinese medicine moxa-moxibustion more than two decades, after can not be resistant to Chinese mugwort cigarette because of body, successfully invented substitution moxibustion product i.e.: house
With transdermal delivery device application targeting thermochemotherapy is targeted outside Electvic heating physiogherapy, had recorded by a definite date in my " moxa-moxibustion diagnosis and treatment portion "
5 years clinical practice data have had accumulated orthopaedics chronic ache illness quite mature working specification, also sense of reality
Patient's；All kinds of chronic pains such as lumbar vertebra disease, cervical spondylosis, arteriosclerosis and obstruction of lower limbs, osteoproliferation, scapulohumeral periarthritis, sciatica, rheumatism bone disease
Pain from pain to be completely successful cure up to 2 years or more do not recur.The simple and practical innovation medical technology of the present invention, is intended to
It treats in chronic ache effect and application to show its clinical value, is evaluated by chronic ache；1-3 grades of mild pain, pain is slight,
Energy normal life does not influence to sleep；4-6 grades of moderate pain, show as lasting severe pain, sleep is disturbed, need to use analgestic；Severe
7-9 grades of pain, strong duration severe pain can be seriously disturbed with forced position and autonomic nervous dysfunction, sleep.
The present invention judges as follows for the effective result of chronic ache: 1-3 grades of one Zhou Zhiyu of mild pain.4-6 grades of moderate pains
Pain half a year cures, 7-9 grades of one Nian Zhiyu of severe pain.Criterion of therapeutical effect: 2 years or more pain does not recur to cure.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (5)
1. targeting transdermal delivery device outside domestic electric heating physical therapy, which is characterized in that including electric heating layer (1), anti-leakage layer (3) and
It impregnates medicament layer (4), anti-leakage layer (3) setting is between electric heating layer (1) and dipping medicament layer (4), the electric heating
Package is provided with insulating layer (2) layer (1) outside, and electric heating layer (1) is specifically heated using electrical heating elements.
2. targeting transdermal delivery device outside domestic electric heating physical therapy as described in claim 1, which is characterized in that the electric heating layer
(1) electrical heating elements specifically use far infrared carbon fiber to be made.
3. targeting transdermal delivery device outside domestic electric heating physical therapy as described in claim 1, which is characterized in that the insulating layer
(2) insulating materials used is specially Teflon or silica gel.
4. targeting transdermal delivery device outside domestic electric heating physical therapy as described in claim 1, which is characterized in that the anti-leakage layer
It (3) is specially anti-heat leakage towel, anti-heat leakage towel is made of 80% polyester fiber and 20% Fypro.
5. targeting transdermal delivery device outside domestic electric heating physical therapy as described in claim 1, which is characterized in that the dipping medicament
Layer (4) material is specifically adopted the degreasing cotton gauze piece impregnated of medicament and is made.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910098567.XA CN109793983A (en) | 2019-01-31 | 2019-01-31 | Transdermal delivery device is targeted outside domestic electric heating physical therapy |
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| CN201910098567.XA CN109793983A (en) | 2019-01-31 | 2019-01-31 | Transdermal delivery device is targeted outside domestic electric heating physical therapy |
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Cited By (1)
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| CN110876832A (en) * | 2019-11-19 | 2020-03-13 | 南京从景生物技术有限公司 | An electronic patch for transdermal drug delivery based on radio frequency radiator |
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|---|---|---|---|---|
| CN110876832A (en) * | 2019-11-19 | 2020-03-13 | 南京从景生物技术有限公司 | An electronic patch for transdermal drug delivery based on radio frequency radiator |
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