CN109731126A

CN109731126A - A kind of biological dressing with skin repairing function and preparation method thereof

Info

Publication number: CN109731126A
Application number: CN201910071143.4A
Authority: CN
Inventors: 付磊
Original assignee: Finsen Health Technology Guangzhou Center LP
Current assignee: Finsen Health Technology Guangzhou Center LP
Priority date: 2019-01-25
Filing date: 2019-01-25
Publication date: 2019-05-10

Abstract

The invention discloses a biological dressing with a skin repairing function, which consists of a base material and a liquid medicament attached to the base material, wherein the preparation raw materials of the liquid medicament contain active peptide, growth factors, a hyaluronic acid composition, glycerol, mushroom glucan, polygonatum polysaccharide, phloretin, prinsepia utilis royle oil, an aloe extract, a tremella extract, a nitraria flower extract, a phoenix-tail fern extract and a honey extract. The hyaluronic acid, the growth factors and the plant extracts are matched for use and have synergistic interaction, so that the composition with the functions of moisturizing, repairing, detumescence and antioxidation is obtained, can be used as a medical dressing and is used for treating and nursing dermatitis, eczema, skin allergy and superficial injury (such as sunburn).

Description

A kind of biological dressing and preparation method thereof with reparation skin function

Technical field

The present invention relates to a kind of with the biological dressing and preparation method thereof for repairing skin function.

Background technique

Skin is the first barrier protected between body and nature, can prevent the invasion of environmental pathogenic microorganism with And the loss of itself body fluid.Skin is a very important organ of body, but skin trauma is also very in life Common, skin disruption and defect are not only resulted in, ugly scar but will be left after wound.The reparation of human body skin damnification, It is a complicated physiology course, the formation and hyperplasia of scar, are always the difficulty for perplexing people after the healing rate of wound, healing Topic.

With the raising of patient requests, the requirement to skin-rehabilitating agent is also higher and higher.Existing skin repair composition Western medicine is mostly used to be made, raw material is not safe enough, and is easy to stay scar.Therefore, the present invention provides a kind of preventing from scar, using safe Biological dressing and preparation method thereof.

Summary of the invention

The purpose of the present invention is to provide a kind of with the biological dressing and preparation method thereof for repairing skin function.

The technical solution used in the present invention is:

A kind of composition with reparation skin function, by percentage to the quality, preparing in raw material for composition contains 0.001%~0.002% active peptide, 0.005%~0.01% growth factor, 0.1%~1% hyaluronic acid compositions, 0.5% ~1% glycerol, 0.1%~0.5% mushroom glucan, 0.01%~0.1% Siberian solomonseal rhizome polysaccharide, 0.01%~0.2% phloretin, It is 0.01%~0.1% prinsepia utilis royle oil, 0.1~2% aloe extract, 0.2%~1% dried tremella extract, 0.01%~0.1% white Tattooing extract, 0.02%~0.06% Herba Pteridis Multifidae extract, 0.1%~0.2% Mel extract, excess water.

Further, active peptide is oligopeptides -1.

Further, growth factor is made of the raw material of following mass parts: 45~55 parts of EGF；20~30 parts of KGF；20 parts ~30 parts of FGF.

Further, in terms of the relative molecular weight Mr of hyaluronic acid, hyaluronic acid compositions by following mass parts raw material Composition:

10~40 parts of the high molecular weight hyaluronic acid of Mr >=2,000,000；

1~20 part of the middle-molecular-weihydroxyethyl hyaluronic acid of 200000≤Mr < 2,000,000；

1~20 part of the low-molecular-weight hyaluronic acid of 10000≤Mr < 200,000；

1~20 part of the oligomerization hyaluronic acid of Mr < 10,000.

Further, water is deionized water.

Further, the above-mentioned composition with reparation skin function, it is characterised in that: preparation method includes following step It is rapid:

1) Sodium Hyaluronate and water are mixed, stirring and dissolving obtains solution A；

2) active peptide, growth factor, glycerol, mushroom glucan, Siberian solomonseal rhizome polysaccharide, phloretin, prinsepia utilis royle oil, aloe are extracted Object, dried tremella extract, Sophora viciifolia extract, Herba Pteridis Multifidae extract, Mel extract, water mixing, stir evenly, obtain solution B；

3) solution A, B are mixed, is stirred evenly；

The volume ratio for the water that wherein step 1) and step 2) are added is 1:(1~10).

A kind of biological dressing with reparation skin function is made of, liquid substrate and attachment liquid pharmaceutical on base material State medicament is combinations of the above object.

Further, substrate is fabric or non-woven fabrics.

Further, the fabric in substrate is cotton, hair, silk, fiber crops, bamboo and wood slurry, viscose rayon, chitosan fiber, work At least one of property Carbon fibe, terylene, polyamide fibre, polypropylene fibre, spandex, aramid fiber, acetate fiber, polyurethane fiber.

Hyaluronic acid, also known as uronic acid, be repeat connection by n-acetylglucosamine and D- glucuronic acid dissacharide units and At polymeric acidic mucopolysaccharide, be widely present in animal and human connective tissue extracellular matrix.Hyaluronic acid has wide General physicochemical property and biological function abundant, is especially suitable for reparation, protection and the nursing to skin.

Growth factor accelerates the metabolism of cell to the adjustment effect of epidermis, skin corium, and the nutrition of cell is promoted to inhale It receives, and adjusts the vigor of skin cell metabolism, special biological enzyme in breathing, adjust fibroblastic activity, make skin Elasticity is kept, wrinkle is removed, promotes the formation of neoplastic skin, reduces pigment composition in Skin Cell, mitigates the heavy of skin pigment , cell can be promoted to grow, accelerate to update, capillary tissue abundant provides nutrient for Skin Cell, leads to Skin Cell Flush, be ruddy, there is preferable repair for injured Skin Cell, accelerating the healing of wound, at the same reduce and Remove scar.

Mushroom glucan is a kind of beta glucan from schizophyllum commune, residual in each third glucose of β -1,3 main chains Generate a β -1 on base, 6 branches, to make it have promotion wound healing, strengthen immunity, moisturizing is anti-inflammatory and other effects, simultaneously Mushroom glucan can accelerate the synthesis of collagen, promote skin cell proliferation and reparation.

Rhizoma polygonati is Liliaceae Polygonatum herbaceos perennial rhizome, and Siberian solomonseal rhizome polysaccharide is the most important active constituent of rhizoma polygonati, Siberian solomonseal rhizome polysaccharide has excellent performance of keeping humidity according to the literature.

Phloretin is a kind of plant polyphenol with dihydrochalcone structure, due to it focuses mostly in the root skin of apple tree It gains the name, has the effects that anti-oxidant, promotion skin absorption, whitening, moisturizing.In vitro study shows that phloretin being capable of inflammation always The generation of the factor, chemotactic factor (CF) and differentiation factor has certain anti-inflammatory effect.Phloretin can also inhibit to inhibit monocyte The ability of keratinocyte is adhered to, the phosphorylation of signal protein kinases AKt and MAPK is hindered, to reach antiphlogistic effects.Root Pi Su has stronger inhibiting effect as a kind of chromocor compound, to gram-positive bacteria, also has suppression to skin common bacteria The effect of killing.

Prinsepia utilis royle oil is a kind of pure natural skin care grease, vitamin and unsaturated fatty acid rich in, wherein oleic acid 70% or more is up to linoleic content.It is very close with human body lipid, so being very easy to be protected by human skin absorption Hold moisture, nutrition and the elasticity of skin.Prinsepia utilis royle oil to skin have it is apparent promote infiltration effect, mainly due to its composition ingredient with The ingredient of the composition of natural moisturizing factor is consistent in cuticula, so easily permeating free water shape in application on human skin, with cuticula At secondary combination water or the reticular structure of associated water, keep moisture not easy to lose, there is good moistening effect.

Aloe is with a long history for beauty, excellent, and the history worldwide applied is five, 6,000 years existing, Aloe has the function of anti-inflammation and sterilization, promotes wound healing, cell-activating, reduces skin oil and fat and melanin secretion, main Containing 99.5% aqueous viscose glue and mucopolysaccharide and Choline Salicylate.

Tremella contains protein, fat and a variety of amino acid, minerals and glycogen, and wherein calcium, the content of iron are very high.This Outside, also containing glycogen such as trehalose, pentosan, mannitols in tremella, nutritive value is very high, with the work that righting is strong With being described as " hat in bacterium " by people, be both the strong tonic of rare nutritious tonifying good merchantable brand and righting, have to skin Beauty, tender skin, it is anti-ageing the effect of.

Sophora viciifolia is the flower of Papilionaceae plant Sophora viciifolia, is that Han nationality is civil and ethnic groups' medication such as Miao ethnic group, Hani. There is document report Sophora viciifolia extract that there is anti-inflammatory, antianaphylactic effect.

Mel extract is the active matter extracted from the nectar that honeybee acquires.Rich in amino acid, oligosaccharides (glucose, fruit Sugar, sucrose and maltose), the minerals such as organic acid (lactic acid, gluconic acid) and calcium and magnesium, sodium and potassium.Honeybee extracting solution is mainly in skin The cuticula of skin works.With preferable moisture regulation effect and hygroscopicity, particularly suitable for drying, coarse and shortage water conservation The skin of property substance, it can supplement the natural moisturizing factor of skin losses, enhance the water imbibition of keratoderma in low humidity In the case of moisture still can be absorbed from atmosphere, supplement the moisture loss of cuticula.

The beneficial effects of the present invention are:

The present invention is used by the way that hyaluronic acid, growth factor and plant extracts are arranged in pairs or groups, synergistic, obtains a kind of tool Have moisturizing, reparation, detumescence, anti-oxidation function composition, can be used as medical dressing, for dermatitis, eczema, skin allergy, shallow Table damages the treatment and nursing of (such as sunburn).

Specific embodiment

Below in conjunction with embodiment, the present invention is further explained, it should be appreciated that following embodiment be merely to illustrate the present invention and It is not used in and limits the scope of the invention.

Biological dressing is made of substrate and attachment liquid pharmaceutical on base material in Examples 1 to 5 and comparative example 1~3, liquid State reagent combination is as shown in the table:

Active peptide is oligopeptides -1；

Growth factor is made of the raw material of following mass parts: 45~55 parts of EGF；20~30 parts of KGF；20 parts~30 parts FGF. In terms of the relative molecular weight Mr of hyaluronic acid, hyaluronic acid compositions are made of the raw material of following mass parts:

10~40 parts of the high molecular weight hyaluronic acid of Mr >=2,000,000；

1~20 part of the oligomerization hyaluronic acid of Mr < 10,000；

Water is deionized water.

Biological dressing the preparation method comprises the following steps:

3) solution A, B are mixed, is uniformly mixing to obtain liquid preparation；

4) liquid pharmaceutical is attached on substrate in the method for being coated with, adhering or impregnate, obtains biological dressing

Performance evaluation

One, Super pulse CO₂It is repaired after dot matrix laser operation

It finds gently to depressed scar after severe acne, and receives Super pulse CO₂The patient of dot matrix laser therapy 90, Middle male 45, women 45, the age 18~39 years old.9 groups are randomly divided into, every group of 10 people, wherein 5 groups of aspiration testing example 1 ~5,3 groups of test comparison examples 1~3, last group are used as blank control.Postoperative, 5 groups of embodiment are respectively adopted Examples 1 to 5 Biological dressing, three groups of comparative example of the biological dressing that comparative example 1~3 is respectively adopted is sooner or later each daily to be applied with 1 time, continuously makes With 10 days.Select homemade cold water ice bag progress cold compress as blank control simultaneously, same each external application is primary sooner or later daily, continuously It uses 10 days.During test, patient be required to it is postoperative stringent sun-proof, every group just common aureomycin hydrochloride eye ointment external application 2 times/ It, continuous three days.

Scored according to inflammatory reaction within the 5th day in test, scored by degree from 1 point~5 points, 1 point indicate without Erythema, oedema, burning heat sensation；5 points indicate apparent erythema, oedema and scorching hot, cusalgia.Test result is shown in Table 1, shown in It is divided into the average mark of every group of 10 people.

1 inflammatory reaction of table scoring

Exhort volunteer record surface of a wound scab forming time, decrustation time and whole decrustation times at first, the time Average value (day) 2 can be shown in Table.

Table 2 averagely incrustation and decrustation time

Two, acne scars reparation

It collects 90 patients with acne and carries out scar repairing test, wherein male 30, women 60, the age 18~30 years old. It is randomly divided into 9 groups, every group of 10 people, 5 groups of embodiment of the biological dressing that Examples 1 to 5 is respectively adopted, the difference that three groups of comparative example It is sooner or later each daily to be applied with 1 time using the biological dressing of comparative example 1~3, it is used continuously 15 days；Last group is selected commercially available general Logical dressing is applied with, same to be applied with sooner or later once daily, is used continuously 15 days.

Volunteer scores according to skin lesion form, scores by erythema/pigment degree from 0 point~5 points, wherein 0 point It indicates to observe under available light, is visible by naked eyes erythema/pigmentation；It is observed under 3 points of expression available lights, moderate erythema/color It is plain calm, the more red yellow brown of color；It is observed under 5 points of expression available lights, severe erythema/pigmentation, color is scarlet/deep to take off Color.

The appraisal result of acne scars reparation is shown in Table 3, and the score value is average mark.

The scoring of 3 acne scars repairing effect of table

From above-mentioned Evaluation results it is found that dressing of the invention can promote wound healing, prevention and reduce scar It is formed.

Claims

1. A composition with skin repairing function, characterized in that: in mass percentage, the preparation raw materials of the composition contain 0.001%-0.002% active peptide, 0.005%-0.01% growth factor, 0.1%-1% transparent Lonic acid composition, 0.5%-1% glycerin, 0.1%-0.5% mushroom glucan, 0.01%-0.1% polysaccharide polysaccharide, 0.01%-0.2% phloretin, 0.01%-0.1% prickly pear oil, 0.1% ~2% aloe vera extract, 0.2%~1% tremella extract, 0.01%~0.1% white thorn flower extract, 0.02%~0.06% anchovy extract, 0.1%~0.2% honey extract, balance water .

2 . The composition according to claim 1 , wherein the active peptide is oligopeptide-1. 3 .

3. The composition according to claim 1, wherein the growth factor is composed of the following raw materials by mass: 45-55 parts EGF; 20-30 parts KGF; 20-30 parts FGF.

4. the composition with skin repair function according to claim 1, is characterized in that: in the relative molecular weight Mr of hyaluronic acid, the hyaluronic acid composition is made up of the raw material of following mass parts:

10-40 copies of high molecular weight hyaluronic acid with Mr≥2 million;

200,000≤Mr<2,000,000 1-20 copies of medium molecular weight hyaluronic acid;

1-20 copies of low molecular weight hyaluronic acid with 10,000≤Mr<200,000;

1-20 copies of oligomeric hyaluronic acid with Mr<10,000.

5. The composition with skin repairing function according to claim 1, wherein the water is deionized water.

6. The composition with skin repairing function according to any one of claims 1 to 5, wherein the preparation method comprises the following steps:

1) mixing sodium hyaluronate and water, stirring and dissolving to obtain solution A;

2) Extract active peptides, growth factors, glycerin, mushroom glucan, polysaccharide polysaccharide, phloretin, green thorn fruit oil, aloe vera extract, white fungus extract, white thorn flower extract, anchovy extract, honey mixed with water, and stirred evenly to obtain solution B;

3) Mix solution A and B and stir evenly;

The volume ratio of the water added in step 1) and step 2) is 1:(1-10).

7 . A biological dressing with skin repairing function, which is composed of a base material and a liquid medicament attached to the base material, wherein the liquid medicament is the composition according to any one of claims 1 to 6 .

8 . The biological dressing with skin repairing function according to claim 7 , wherein the base material is fibrous fabric or non-woven fabric. 9 .

9. The biological dressing with skin repair function according to claim 8, wherein the fiber fabric in the base material is cotton, wool, silk, hemp, bamboo, wood pulp, viscose fiber, chitosan fiber, activated carbon At least one of fiber, polyester, nylon, polypropylene, spandex, aramid, acetate fiber, and polyurethane fiber.