CN109701161B - A method of stimulating convulsions in the motor cortex of the brain - Google Patents
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Abstract
本发明实施例提供一种刺激大脑运动皮层抽搐的方法，包括：确定第一电压值，具有第一电压值的电压作为刺激线圈的输入所产生的磁场对大脑运动皮层的刺激强度达到运动阈值；根据第一电压值，确定第一频率，具有第一频率和第一振幅的脉冲电压作为刺激线圈的输入所产生的磁场对大脑运动皮层的刺激强度达到抽搐阈值，第一振幅为第一电压值的两倍；根据第一电压值和第一频率生成驱动电压，将驱动电压输入至刺激线圈并持续输入第一预设时长，以使刺激线圈所产生的磁场刺激大脑运动皮层抽搐，驱动电压为具有第一频率和第二振幅的脉冲电压，第二振幅为第一电压值的四倍。本方法达到在短时间内筛选出有效的、刺激强度最小的刺激方案来刺激大脑运动皮层抽搐。
An embodiment of the present invention provides a method for stimulating convulsions in the motor cortex of the brain, including: determining a first voltage value, and using the voltage with the first voltage value as the input of the stimulating coil to generate a magnetic field that stimulates the motor cortex of the brain to reach a motor threshold; According to the first voltage value, the first frequency is determined, the pulse voltage with the first frequency and the first amplitude is used as the input of the stimulating coil, and the magnetic field generated by the input of the stimulating coil reaches the convulsion threshold, and the first amplitude is the first voltage value The driving voltage is generated according to the first voltage value and the first frequency, and the driving voltage is input to the stimulating coil and continuously input for the first preset duration, so that the magnetic field generated by the stimulating coil stimulates the cerebral motor cortex to twitch. The driving voltage is A pulsed voltage having a first frequency and a second amplitude, the second amplitude being four times the value of the first voltage. The method achieves screening out an effective stimulation scheme with the smallest stimulation intensity in a short time to stimulate the convulsions of the cerebral motor cortex.
Description
技术领域technical field
本发明实施例涉及生物刺激技术领域，更具体地，涉及一种刺激大脑运动皮层抽搐的方法。The embodiments of the present invention relate to the technical field of biostimulation, and more specifically, to a method for stimulating convulsions of the motor cortex of the brain.
背景技术Background technique
MST(Magnetic seizure therapy)技术是20世纪80年代中期发展起来的一种影响和改变大脑功能的生物刺激技术。并且随着技术的发展,它在临床医学方面的应用也越来越得到人们的重视，MST是利用时变磁场作用于大脑运动皮层产生感应电流改变皮层神经细胞的动作电位，从而影响脑内代谢和神经电活动的生物刺激技术，并且对于某些改变大脑功能的刺激，要求大脑运动皮层产生抽搐。MST (Magnetic seizure therapy) technology is a biostimulation technology developed in the mid-1980s to affect and change brain functions. And with the development of technology, its application in clinical medicine has attracted more and more attention. MST uses a time-varying magnetic field to act on the motor cortex of the brain to generate an induced current to change the action potential of the cortical nerve cells, thereby affecting the metabolism of the brain. Biostimulation techniques for electrical and neural activity, and for certain stimuli that alter brain function, require twitches in the motor cortex of the brain.
目前基于MST技术的设备(例如经颅磁刺激仪)还处于试验阶段，设备中刺激参数多，刺激方案组合多，设置复杂，难以确定理想的刺激方案刺激抽搐发作。刺激方案中可以调节的参数有刺激强度(以设备最大输出磁场强度的1-100％表示)，刺激强度通过输入到刺激线圈的电压值来调节、刺激频率1-100Hz可调，刺激频率也是通过输入到刺激线圈的电压的频率来调节，刺激时间1-10秒可调，刺激时间同样是通过输入到刺激线圈的电压的持续输入时间来调节，3个参数都有100种选择，共有1003个排列组合，可形成100万个的刺激方案，因此选择合理的方案很困难。现在MST技术中的刺激操作是用0.1Hz低频刺激逐渐增大刺激剂量，每隔10秒刺激一次，测得个体的运动阈值(最小引起肌肉收缩的刺激量)，然后用ECT(Electric convulsive therapy)的经验调节刺激参数，测量抽搐阈值(最小引起抽搐的刺激量)用100％输出强度，100Hz频率，每隔20秒逐渐增加刺激串的时间来确定抽搐阈值，确定了抽搐阈值后再把阈值乘以2-4倍的刺激量，整个操作过程需要人工操作，特别繁杂而且耗时。由于刺激强度和刺激频率都是100％，仅仅改变刺激时间经常出现过度刺激而发生不必要的副作用。并且由于人脑解剖结构的差异、生理与病理状态的差异、线圈刺激部位的差异、抽搐后神经功能发生变化的差异、每次磁刺激操作差异等因素影响，使MST很难选择适合个体化的合理化的方案，目前没有一个通用的、固定的刺激诱发抽搐的模式。刺激方案中很难选择合理的抽搐刺激量和刺激方法，靠反复选择和调试各种刺激方案，刺激量过小不能引起抽搐，刺激过强除了要求设备输出更大功率、增加设备制造难度，还可以引起过度刺激，引起四肢酸痛或潜在的脑细胞损伤。At present, equipment based on MST technology (such as transcranial magnetic stimulator) is still in the experimental stage. There are many stimulation parameters in the equipment, and there are many combinations of stimulation schemes, and the settings are complicated. It is difficult to determine the ideal stimulation scheme to stimulate convulsions. The parameters that can be adjusted in the stimulation program include stimulation intensity (expressed as 1-100% of the maximum output magnetic field strength of the device), the stimulation intensity is adjusted by the voltage value input to the stimulation coil, and the stimulation frequency is adjustable from 1-100Hz. The frequency of the voltage input to the stimulating coil is adjusted, and the stimulation time is adjustable from 1 to 10 seconds. The stimulation time is also adjusted by the continuous input time of the voltage input to the stimulating coil. There are 100 options for the three parameters, and there are 100 3 in total. A permutation and combination can form 1 million stimulus plans, so it is difficult to choose a reasonable plan. The current stimulation operation in MST technology is to use 0.1Hz low-frequency stimulation to gradually increase the stimulation dose, stimulate once every 10 seconds, measure the individual's motor threshold (the minimum stimulation amount that causes muscle contraction), and then use ECT (Electric convulsive therapy) Adjust the stimulus parameters based on experience, measure the twitch threshold (the minimum amount of twitch-causing stimulation), use 100% output intensity, 100Hz frequency, and gradually increase the time of the stimulation string every 20 seconds to determine the twitch threshold, and then multiply the threshold by With 2-4 times the amount of stimulation, the entire operation process requires manual operation, which is extremely complicated and time-consuming. Since the stimulation intensity and stimulation frequency are both 100%, merely changing the stimulation time often leads to overstimulation and unnecessary side effects. Moreover, due to factors such as differences in human brain anatomy, differences in physiological and pathological states, differences in coil stimulation sites, differences in nerve function changes after convulsions, and differences in each magnetic stimulation operation, it is difficult to choose a suitable one for MST. Rationalized schemes, there is currently no universal, fixed pattern of stimulus-evoked convulsions. It is difficult to choose a reasonable twitch stimulation amount and stimulation method in the stimulation plan. By repeatedly selecting and debugging various stimulation plans, the stimulation amount is too small to cause convulsions, and the stimulation is too strong. Can cause overstimulation, causing sore limbs or potential brain cell damage.
MST技术的刺激方案中有刺激强度、刺激频率和刺激时间3个常规的刺激参数，每个参数有100个可选值，排列组合的选择千变万化。如果加上近年来TMS(Transcranialmagnetic stimulation)增加的成对刺激、爆发刺激式和四联刺激等模式，其刺激方案更是不计其数。操作者面对众多的选择常常无所适从，很难在短时间内筛选出有效的、最短时间、最小刺激诱发抽搐的方法。In the stimulation program of MST technology, there are three conventional stimulation parameters: stimulation intensity, stimulation frequency and stimulation time. Each parameter has 100 optional values, and the selection of permutations and combinations is ever-changing. If you add the paired stimulation, burst stimulation and quadruple stimulation of TMS (Transcranialmagnetic stimulation) in recent years, there are countless stimulation options. Operators are often at a loss in the face of numerous choices, and it is difficult to screen out an effective, shortest time, and minimal stimulus-induced convulsion method in a short period of time.
发明内容Contents of the invention
为了克服上述问题或者至少部分地解决上述问题，本发明实施例提供一种刺激大脑运动皮层抽搐的方法。In order to overcome the above problems or at least partly solve the above problems, an embodiment of the present invention provides a method for stimulating cerebral motor cortex to twitch.
本发明实施例提供一种刺激大脑运动皮层抽搐的方法，包括：确定第一电压值，其中，将具有第一电压值的电压作为刺激线圈的输入，以使刺激线圈所产生的磁场对大脑运动皮层的刺激强度达到运动阈值，刺激线圈置于大脑运动皮层上方；根据第一电压值，确定第一频率，其中，将具有第一频率和第一振幅的脉冲电压作为刺激线圈的输入，以使刺激线圈所产生的磁场对大脑运动皮层的刺激强度达到抽搐阈值，第一振幅为第一电压值的两倍；根据第一电压值和第一频率生成驱动电压，将驱动电压输入至刺激线圈并持续输入第一预设时长，以使刺激线圈所产生的磁场刺激大脑运动皮层抽搐，其中，驱动电压为具有第一频率和第二振幅的脉冲电压，第二振幅为第一电压值的四倍。An embodiment of the present invention provides a method for stimulating convulsions in the motor cortex of the brain, including: determining a first voltage value, wherein the voltage with the first voltage value is used as the input of the stimulating coil, so that the magnetic field generated by the stimulating coil can affect the movement of the brain. The stimulation intensity of the cortex reaches the motor threshold, and the stimulation coil is placed above the motor cortex of the brain; according to the first voltage value, the first frequency is determined, wherein the pulse voltage with the first frequency and the first amplitude is used as the input of the stimulation coil, so that The stimulation intensity of the magnetic field generated by the stimulating coil to the cerebral motor cortex reaches the convulsion threshold, and the first amplitude is twice the first voltage value; a driving voltage is generated according to the first voltage value and the first frequency, and the driving voltage is input to the stimulating coil and Continuous input of the first preset duration, so that the magnetic field generated by the stimulating coil stimulates the cerebral motor cortex to twitch, wherein the driving voltage is a pulse voltage with a first frequency and a second amplitude, and the second amplitude is four times the value of the first voltage .
其中，将驱动电压输入至刺激线圈并持续输入第一预设时长之前，还包括：将频率为50Hz和第三振幅的脉冲电压输入连续的5个脉冲至刺激线圈，以使刺激线圈所产生的磁场对大脑运动皮层进行预刺激，其中，第三振幅为第二电压值，第二电压值不超过第一电压值。Wherein, before inputting the driving voltage to the stimulating coil and continuing to input the first preset duration, it also includes: inputting 5 continuous pulses with a frequency of 50 Hz and a third amplitude to the stimulating coil, so that the stimulating coil produces The magnetic field pre-stimulates the motor cortex of the brain, wherein the third amplitude is the second voltage value, and the second voltage value does not exceed the first voltage value.
其中，将驱动电压输入至刺激线圈并持续输入第一预设时长之后，还包括：获取驱动电压输入至刺激线圈，以使刺激线圈所产生的磁场刺激大脑运动皮层后的第一血压信号；若确定第一血压信号的强度未满足预设条件，则在第二预设时长后，基于前一输入至刺激线圈的驱动电压的持续输入时间，以第一预设步长逐步增加驱动电压输入至刺激线圈的持续输入时间，直至确定第一血压信号的强度满足预设条件或者驱动电压的持续输入时间达到持续时间上限值，其中，预设条件为第一血压信号的强度超过预设血压强度阈值的持续时间至少为第三预设时长。Wherein, after inputting the driving voltage to the stimulating coil and continuing to input the first preset duration, it also includes: obtaining the driving voltage input to the stimulating coil, so that the magnetic field generated by the stimulating coil stimulates the first blood pressure signal after the motor cortex of the brain; if If it is determined that the intensity of the first blood pressure signal does not meet the preset condition, then after the second preset time length, based on the last input time of the previous driving voltage input to the stimulation coil, gradually increase the driving voltage input to the stimulation coil with a first preset step size. Stimulate the continuous input time of the coil until it is determined that the strength of the first blood pressure signal meets the preset condition or the continuous input time of the driving voltage reaches the upper limit value of the duration, wherein the preset condition is that the strength of the first blood pressure signal exceeds the preset blood pressure strength The duration of the threshold is at least a third preset duration.
其中，基于前一输入至刺激线圈的驱动电压的持续输入时间，以第一预设步长逐步增加驱动电压输入至刺激线圈的持续输入时间之后，还包括：若确定驱动电压的持续输入时间达到持续时间上限值且第一血压信号的强度未满足预设条件，则在第二预设时长后，将具有第二频率和第四振幅的脉冲电压输入至刺激线圈并持续输入持续时间上限值，以使刺激线圈所产生的磁场刺激大脑运动皮层抽搐，第二频率为频率上限值，第四振幅为电压上限值。Wherein, based on the previous continuous input time of the driving voltage input to the stimulating coil, after gradually increasing the continuous input time of the driving voltage input to the stimulating coil with the first preset step size, it also includes: if it is determined that the continuous input time of the driving voltage reaches The duration upper limit value and the strength of the first blood pressure signal does not meet the preset condition, then after the second preset duration, input the pulse voltage with the second frequency and the fourth amplitude to the stimulation coil and continue to input the duration upper limit value, so that the magnetic field generated by the stimulating coil stimulates the cerebral motor cortex to twitch, the second frequency is the frequency upper limit, and the fourth amplitude is the voltage upper limit.
其中，确定第一电压值，包括：逐一将频率为50Hz的第一测试脉冲电压输入至刺激线圈，每一输入到刺激线圈的第一测试脉冲电压持续5个脉冲，后一第一测试脉冲电压的振幅基于前一第一测试脉冲电压的振幅以第二预设步长增加；在每次将第一测试脉冲电压输入至刺激线圈后，获取第一测试脉冲电压输入至刺激线圈，以使刺激线圈所产生的磁场刺激大脑运动皮层后的复合肌电信号，直至确定复合肌电信号的最大值超过第一预设值；将复合肌电信号的最大值超过第一预设值时对应的第一测试脉冲电压的振幅作为第一电压值。Wherein, determining the first voltage value includes: inputting first test pulse voltages with a frequency of 50 Hz to the stimulation coil one by one, each first test pulse voltage input to the stimulation coil lasts for 5 pulses, and the next first test pulse voltage The amplitude of the first test pulse voltage is increased with a second preset step size based on the amplitude of the previous first test pulse voltage; after each time the first test pulse voltage is input to the stimulation coil, the first test pulse voltage is obtained and input to the stimulation coil, so that the stimulation The magnetic field generated by the coil stimulates the composite electromyographic signal after the motor cortex of the brain until it is determined that the maximum value of the composite electromyographic signal exceeds the first preset value; when the maximum value of the composite electromyographic signal exceeds the first preset value, the corresponding The amplitude of a test pulse voltage is used as the first voltage value.
其中，根据第一电压值，确定第一频率，包括：逐一将具有第一振幅的第二测试脉冲电压输入至刺激线圈，每一输入到刺激线圈的第二测试脉冲电压持续输入第四预设时长，后一第二测试脉冲电压的频率基于前一第二测试脉冲电压的频率以第三预设步长增加；在每次将第二测试脉冲电压输入至刺激线圈后，获取第二测试脉冲电压输入至刺激线圈，以使刺激线圈所产生的磁场刺激大脑运动皮层后的第二血压信号，直至确定第二血压信号的最大值超过第二预设值；将第二血压信号的最大值超过第二预设值时对应的第二测试脉冲电压的频率作为第一频率。Wherein, according to the first voltage value, determining the first frequency includes: inputting the second test pulse voltage with the first amplitude to the stimulation coil one by one, and each second test pulse voltage input to the stimulation coil is continuously input into the fourth preset Duration, the frequency of the latter second test pulse voltage is increased with a third preset step based on the frequency of the previous second test pulse voltage; after the second test pulse voltage is input to the stimulating coil each time, the second test pulse is obtained The voltage is input to the stimulating coil, so that the magnetic field generated by the stimulating coil stimulates the second blood pressure signal after the motor cortex of the brain, until it is determined that the maximum value of the second blood pressure signal exceeds the second preset value; the maximum value of the second blood pressure signal exceeds the second preset value; The frequency of the second test pulse voltage corresponding to the second preset value is used as the first frequency.
本发明实施例提供的一种刺激大脑运动皮层抽搐的方法，包括：确定第一电压值，其中，具有第一电压值的电压作为刺激线圈的输入，以使刺激线圈所产生的磁场对大脑运动皮层的刺激强度达到运动阈值，刺激线圈置于大脑运动皮层上方；根据第一电压值，确定第一频率，其中，具有第一频率和第一振幅的脉冲电压作为刺激线圈的输入，以使刺激线圈所产生的磁场对大脑运动皮层的刺激强度达到抽搐阈值，第一振幅为第一电压值的两倍；根据第一电压值和第一频率生成驱动电压，将驱动电压输入至刺激线圈并持续输入第一预设时长，以使刺激线圈所产生的磁场刺激大脑运动皮层抽搐，其中，驱动电压为具有第一频率和第二振幅的脉冲电压，第二振幅为第一电压值的四倍。本方法根据运动阈值确定第一电压值，并根据抽搐阈值确定第一频率，再根据第一电压值和第一频率生成驱动电压，通过驱动电压驱动刺激线圈产生磁场，刺激大脑运动皮层抽搐，从而达到在短时间内筛选出有效的、刺激强度最小的刺激方案来刺激大脑运动皮层抽搐。A method for stimulating cerebral motor cortex convulsions provided by an embodiment of the present invention includes: determining a first voltage value, wherein the voltage with the first voltage value is used as the input of the stimulating coil, so that the magnetic field generated by the stimulating coil can affect the brain movement The stimulation intensity of the cortex reaches the motor threshold, and the stimulation coil is placed above the motor cortex of the brain; according to the first voltage value, the first frequency is determined, wherein the pulse voltage with the first frequency and the first amplitude is used as the input of the stimulation coil, so that the stimulation The stimulation intensity of the magnetic field generated by the coil to the motor cortex of the brain reaches the twitch threshold, and the first amplitude is twice the first voltage value; a driving voltage is generated according to the first voltage value and the first frequency, and the driving voltage is input to the stimulating coil and lasts The first preset duration is input so that the magnetic field generated by the stimulating coil stimulates the cerebral motor cortex to twitch, wherein the driving voltage is a pulse voltage with a first frequency and a second amplitude, and the second amplitude is four times the value of the first voltage. The method determines the first voltage value according to the motion threshold, and determines the first frequency according to the twitch threshold, then generates a driving voltage according to the first voltage value and the first frequency, drives the stimulating coil to generate a magnetic field through the driving voltage, and stimulates the motor cortex of the brain to twitch, thereby To achieve in a short period of time to screen out an effective stimulation scheme with the smallest stimulation intensity to stimulate the convulsions of the cerebral motor cortex.
附图说明Description of drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作一简单地介绍，显而易见地，下面描述中的附图是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description These are some embodiments of the present invention. Those skilled in the art can also obtain other drawings based on these drawings without creative work.
图1为根据本发明实施例的刺激大脑运动皮层抽搐的方法的流程图；Fig. 1 is the flow chart of the method for stimulating cerebral motor cortex convulsion according to the embodiment of the present invention;
图2为根据本发明实施例的刺激大脑运动皮层抽搐的装置的示意图。Fig. 2 is a schematic diagram of a device for stimulating convulsions in the motor cortex of the brain according to an embodiment of the present invention.
具体实施方式Detailed ways
为使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.
本发明实施例提供一种刺激大脑运动皮层抽搐的方法，参考图1，包括：S11，确定第一电压值，其中，将具有第一电压值的电压作为刺激线圈的输入，以使刺激线圈所产生的磁场对大脑运动皮层的刺激强度达到运动阈值，刺激线圈置于大脑运动皮层上方；S12，根据第一电压值，确定第一频率，其中，将具有第一频率和第一振幅的脉冲电压作为刺激线圈的输入，以使刺激线圈所产生的磁场对大脑运动皮层的刺激强度达到抽搐阈值，第一振幅为第一电压值的两倍；S13，根据第一电压值和第一频率生成驱动电压，将驱动电压输入至刺激线圈并持续输入第一预设时长，以使刺激线圈所产生的磁场刺激大脑运动皮层抽搐，其中，驱动电压为具有第一频率和第二振幅的脉冲电压，第二振幅为第一电压值的四倍。An embodiment of the present invention provides a method for stimulating convulsions in the cerebral motor cortex. Referring to FIG. 1 , it includes: S11, determining the first voltage value, wherein the voltage with the first voltage value is used as the input of the stimulating coil, so that the stimulating coil The stimulation intensity of the generated magnetic field to the motor cortex of the brain reaches the motor threshold, and the stimulation coil is placed above the motor cortex of the brain; S12, according to the first voltage value, determine the first frequency, wherein the pulse voltage with the first frequency and the first amplitude As the input of the stimulation coil, the stimulation intensity of the magnetic field generated by the stimulation coil to the cerebral motor cortex reaches the convulsion threshold, and the first amplitude is twice the first voltage value; S13, generating a drive according to the first voltage value and the first frequency Voltage, inputting the driving voltage to the stimulating coil and continuously inputting the first preset duration, so that the magnetic field generated by the stimulating coil stimulates the cerebral motor cortex to twitch, wherein the driving voltage is a pulse voltage with the first frequency and the second amplitude, the second The second amplitude is four times of the first voltage value.
具体地，基于MST技术的设备，例如经颅磁刺激仪等主要包括储能电容、可控硅以及刺激线圈，其中，储能电容可提供恒定的电压，再经可控硅调制成脉冲电压后输入到刺激线圈中，刺激线圈在脉冲电压的作用下产生与脉冲电压同频率的瞬变磁场，磁场的强度由脉冲电压的振幅所决定，磁场的持续时长由输入到刺激线圈的电压的持续输入时长决定，由此，基于MST技术的刺激方案中的刺激强度(即磁场强度)、刺激频率(即磁场的频率)和刺激时间(即磁场的持续时间)分别由输入到刺激线圈的电压的电压值、频率和持续时间决定，确定刺激方案也就是确定输入到刺激线圈的电压的电压值、频率和持续时间。Specifically, devices based on MST technology, such as transcranial magnetic stimulators, mainly include energy storage capacitors, thyristors, and stimulation coils. Input to the stimulation coil, the stimulation coil generates a transient magnetic field with the same frequency as the pulse voltage under the action of the pulse voltage, the strength of the magnetic field is determined by the amplitude of the pulse voltage, and the duration of the magnetic field is determined by the continuous input of the voltage input to the stimulation coil The duration is determined, thus, the stimulation intensity (i.e. the magnetic field strength), the stimulation frequency (i.e. the frequency of the magnetic field) and the stimulation time (i.e. the duration of the magnetic field) in the stimulation scheme based on the MST technology are respectively determined by the voltage input to the stimulation coil Determine the value, frequency and duration, determine the stimulation program is to determine the voltage value, frequency and duration of the voltage input to the stimulation coil.
为了在短时间内筛选出有效的、刺激强度最小的刺激方案，本实施例首先确定第一电压值，其中，将具有第一电压值的电压作为刺激线圈的输入，所产生的磁场对大脑运动皮层的刺激强度达到运动阈值，刺激线圈置于大脑运动皮层上方以保证刺激线圈所产生的磁场对大脑运动皮层产生有效的刺激；运动阈值为引起肌肉收缩的最小刺激强度，基于运动阈值来确定第一电压值，能保证第一电压值是可选的最小值；然后根据第一电压值，确定第一频率，其中，将具有第一频率和第一振幅的脉冲电压作为刺激线圈的输入，所产生的磁场对大脑运动皮层的刺激强度达到抽搐阈值，其中，第一振幅为第一电压值的两倍，抽搐阈值是指引起抽搐的最小刺激强度，基于抽搐阈值所确定的第一频率，能保证第一频率是可选的最小值；最后，根据第一电压值和第一频率生成驱动电压，驱动电压为具有第一频率和第二振幅的脉冲电压，将驱动电压输入至刺激线圈并持续输入第一预设时长，以使刺激线圈所产生的磁场刺激大脑运动皮层抽搐，其中，驱动电压的振幅为第一电压值的倍数以及驱动电压的持续输入时间可根据历史经验确定，本实施例中的第二振幅为第一电压值的四倍，第一预设时长可选用六秒；第一电压值可换算成储能电容的最大储能电压的百分比，例如，第一电压值可换算成储能电容的最大储能电压的百分比为20％，则驱动电压的振幅为储能电容的最大储能电压的80％。通过上述的第一电压值和第一频率生成驱动电压，以保证快速确定驱动电压的振幅和频率的下限值，进一步保证在短时间内筛选出有效的、刺激强度最小的刺激方案来刺激大脑运动皮层抽搐，避免刺激强度过大而造成副作用。In order to screen out an effective stimulation plan with the smallest stimulation intensity in a short time, the present embodiment first determines the first voltage value, wherein, the voltage with the first voltage value is used as the input of the stimulation coil, and the generated magnetic field has an effect on brain movement. The stimulation intensity of the cortex reaches the motor threshold, and the stimulation coil is placed above the motor cortex of the brain to ensure that the magnetic field generated by the stimulation coil can effectively stimulate the motor cortex of the brain; A voltage value, which can ensure that the first voltage value is an optional minimum value; then according to the first voltage value, determine the first frequency, wherein, the pulse voltage with the first frequency and the first amplitude is used as the input of the stimulating coil, so The stimulation intensity of the generated magnetic field to the cerebral motor cortex reaches the twitch threshold, wherein the first amplitude is twice the first voltage value, and the twitch threshold refers to the minimum stimulation intensity that causes twitching. The first frequency determined based on the twitch threshold can be Ensure that the first frequency is an optional minimum value; finally, generate a driving voltage according to the first voltage value and the first frequency, the driving voltage is a pulse voltage with the first frequency and the second amplitude, input the driving voltage to the stimulating coil and continue Input the first preset duration, so that the magnetic field generated by the stimulating coil stimulates the cerebral motor cortex to twitch, wherein the amplitude of the driving voltage is a multiple of the first voltage value and the continuous input time of the driving voltage can be determined according to historical experience. In this embodiment The second amplitude is four times the first voltage value, and the first preset duration can be selected as six seconds; the first voltage value can be converted into the percentage of the maximum energy storage voltage of the energy storage capacitor, for example, the first voltage value can be converted into If the percentage of the maximum energy storage voltage of the energy storage capacitor is 20%, the amplitude of the driving voltage is 80% of the maximum energy storage voltage of the energy storage capacitor. The driving voltage is generated by the above-mentioned first voltage value and first frequency to ensure that the lower limit value of the amplitude and frequency of the driving voltage can be quickly determined, and further ensure that an effective stimulation scheme with the smallest stimulation intensity can be screened out in a short time to stimulate the brain The motor cortex twitches to avoid side effects caused by excessive stimulation intensity.
上述驱动电压可通过如图2所示的装置生成并输入到刺激线圈以完成对大脑运动皮层的刺激，其中开关1控制单片机是否启动，单片机2控制储能电容3的充电量和可控硅4的开关频率，储能电容3的电压输入到可控硅4，并经可控硅4调制成与可控硅4的开关频率同频率的脉冲电压，所生成的脉冲电压即为驱动电压，驱动电压输入到位于人体大脑6上方的刺激线圈5，所产生的磁场实现对大脑运动皮层的刺激。The above-mentioned drive voltage can be generated by the device shown in Figure 2 and input to the stimulation coil to complete the stimulation of the motor cortex of the brain, wherein the
本实施例的刺激大脑运动皮层抽搐的方法，根据运动阈值确定第一电压值，并根据抽搐阈值确定第一频率，再根据第一电压值和第一频率生成驱动电压，通过驱动电压驱动刺激线圈产生磁场，刺激大脑运动皮层抽搐，从而达到在短时间内筛选出有效的、刺激强度最小的刺激方案来刺激大脑运动皮层抽搐。In the method for stimulating the twitching of the cerebral motor cortex in this embodiment, the first voltage value is determined according to the motor threshold, and the first frequency is determined according to the twitch threshold, and then the driving voltage is generated according to the first voltage value and the first frequency, and the stimulating coil is driven by the driving voltage A magnetic field is generated to stimulate the twitch of the motor cortex of the brain, so as to screen out an effective stimulation plan with the smallest stimulation intensity in a short time to stimulate the twitch of the motor cortex of the brain.
基于以上实施例，将驱动电压输入至刺激线圈并持续输入第一预设时长之前，还包括：将频率为50Hz和第三振幅的脉冲电压输入连续的5个脉冲至刺激线圈，以使刺激线圈所产生的磁场对大脑运动皮层进行预刺激，其中，第三振幅为第二电压值，第二电压值不超过第一电压值。Based on the above embodiment, before inputting the driving voltage to the stimulating coil and continuing to input the first preset duration, it also includes: inputting 5 continuous pulses with a frequency of 50 Hz and a third amplitude to the stimulating coil, so that the stimulating coil The generated magnetic field pre-stimulates the motor cortex of the brain, wherein the third amplitude is the second voltage value, and the second voltage value does not exceed the first voltage value.
具体地，本实施例在使用驱动电压驱动刺激线圈产生磁场刺激大脑运动皮层之前，还通过刺激强度相对较弱的磁场对大脑运动皮层进行预刺激，这种预刺激能提高大脑运动皮层的兴奋性，以降低抽搐阈值，从而更容易实现通过低强度脉冲磁场实现大脑运动皮层的抽搐；上述对大脑运动皮层进行预刺激的磁场可通过频率为50Hz和第三振幅的脉冲电压驱动刺激线圈产生，并连续驱动5个脉冲，其中，第三振幅为第二电压值，第二电压值不超过第一电压值。Specifically, in this embodiment, before the driving voltage is used to drive the stimulating coil to generate a magnetic field to stimulate the cerebral motor cortex, the cerebral motor cortex is also pre-stimulated by a magnetic field with a relatively weak stimulation intensity, which can increase the excitability of the cerebral motor cortex , to reduce the twitching threshold, so that it is easier to realize the twitching of the cerebral motor cortex through a low-intensity pulsed magnetic field; the above-mentioned magnetic field for pre-stimulating the cerebral motor cortex can be generated by driving the stimulation coil with a pulse voltage with a frequency of 50 Hz and a third amplitude, and Continuously drive 5 pulses, wherein the third amplitude is the second voltage value, and the second voltage value does not exceed the first voltage value.
基于以上实施例，将驱动电压输入至刺激线圈并持续输入第一预设时长之后，还包括：获取驱动电压输入至刺激线圈，以使刺激线圈所产生的磁场刺激大脑运动皮层后的第一血压信号；若确定第一血压信号的强度未满足预设条件，则在第二预设时长后，基于前一输入至刺激线圈的驱动电压的持续输入时间，以第一预设步长逐步增加驱动电压输入至刺激线圈的持续输入时间，直至确定第一血压信号的强度满足预设条件或者驱动电压的持续输入时间达到持续时间上限值，其中，预设条件为第一血压信号的强度超过预设血压强度阈值的持续时间至少为第三预设时长。Based on the above embodiments, after inputting the driving voltage to the stimulating coil for a first preset duration, it also includes: obtaining the driving voltage and inputting it to the stimulating coil, so that the magnetic field generated by the stimulating coil stimulates the first blood pressure after the motor cortex of the brain signal; if it is determined that the intensity of the first blood pressure signal does not meet the preset condition, then after the second preset time length, based on the previous continuous input time of the driving voltage input to the stimulation coil, gradually increase the driving with the first preset step The voltage is input to the stimulation coil for a continuous input time until it is determined that the strength of the first blood pressure signal meets the preset condition or the continuous input time of the driving voltage reaches the upper limit of the duration, wherein the preset condition is that the strength of the first blood pressure signal exceeds the preset condition. The duration of the blood pressure intensity threshold is set to be at least a third preset duration.
具体地，对于大脑运动皮层是否产生抽搐，可通过血压信号来确定，血压信号可通过血压计接收的袖带压力信号来获取，确定脑运动皮层产生抽搐的判定条件可设定为如下预设条件：第一血压信号的强度超过预设血压强度阈值的持续时间至少为第三预设时长，其中，第一血压信号为驱动电压输入至刺激线圈所产生的磁场刺激大脑运动皮层后由血压计测定的血压信号，血压强度阈值可根据历史数据确定，第三预设时长可设定为10秒。Specifically, whether the cerebral motor cortex produces convulsions can be determined by the blood pressure signal, and the blood pressure signal can be obtained through the cuff pressure signal received by the sphygmomanometer, and the determination condition for determining that the cerebral motor cortex produces convulsions can be set as the following preset conditions : The duration of the intensity of the first blood pressure signal exceeding the preset blood pressure intensity threshold is at least the third preset duration, wherein the first blood pressure signal is measured by a sphygmomanometer after the magnetic field generated by the driving voltage input to the stimulation coil stimulates the cerebral motor cortex The blood pressure signal, the blood pressure intensity threshold can be determined according to historical data, and the third preset duration can be set to 10 seconds.
若驱动电压输入至刺激线圈所产生的磁场刺激大脑运动皮层后的第一血压信号的强度未满足预设条件，则说明大脑运动皮层尚未发生抽搐，可在第二预设时长后，第二预设时长可设为20秒，增加驱动电压输入至刺激线圈的输入时间，以保持更长时间的磁场对大脑运动皮层的刺激，所增加的输入时间基于前一输入至刺激线圈的驱动电压的持续输入时间，以第一预设步长逐步增加，以逐步增加对大脑运动皮层的刺激强度，第一预设步长可设为1秒，直至确定第一血压信号的强度满足预设条件或者驱动电压的持续输入时间达到持续时间上限值，其中，持续时间上限值为10秒，该持续时间上限值是为了避免对大脑运动皮层的过长时间的刺激，避免对人体造成不良影响。If the strength of the first blood pressure signal after the driving voltage is input to the magnetic field generated by the stimulating coil to stimulate the cerebral motor cortex does not meet the preset condition, it means that the cerebral motor cortex has not yet convulsed, and after the second preset time length, the second preset The duration can be set to 20 seconds, increasing the input time of the driving voltage input to the stimulating coil to keep the magnetic field for a longer time to stimulate the brain motor cortex, the increased input time is based on the previous input to the driving voltage of the stimulating coil. The input time is gradually increased with the first preset step length to gradually increase the stimulation intensity of the cerebral motor cortex. The first preset step length can be set to 1 second until it is determined that the strength of the first blood pressure signal meets the preset condition or drives The continuous input time of the voltage reaches the upper limit of the duration, wherein the upper limit of the duration is 10 seconds, and the upper limit of the duration is to avoid excessive stimulation of the motor cortex of the brain and to avoid adverse effects on the human body.
上述过程也可通过如图2所示的装置来实现，其中，第二预设时长以及第一预设步长可通过单片机2控制可控硅4来实现，第一血压信号可通过检测仪器中7中的血压计来获取，还可通过检测仪器中7中的脑电图仪和肌电图仪进行辅助检测，各种刺激信号的参数以及血压信号等检测信号可通过显示屏8进行显示。The above process can also be realized by the device shown in Figure 2, wherein the second preset duration and the first preset step can be realized by controlling the silicon controlled
基于以上实施例，基于前一输入至刺激线圈的驱动电压的持续输入时间，以第一预设步长逐步增加驱动电压输入至刺激线圈的持续输入时间之后，还包括：若确定驱动电压的持续输入时间达到持续时间上限值且第一血压信号的强度未满足预设条件，则在第二预设时长后，将具有第二频率和第四振幅的脉冲电压输入至刺激线圈并持续输入持续时间上限值，以使刺激线圈所产生的磁场刺激大脑运动皮层抽搐，第二频率为频率上限值，第四振幅为电压上限值。Based on the above embodiments, based on the previous continuous input time of the driving voltage input to the stimulating coil, after gradually increasing the continuous input time of the driving voltage input to the stimulating coil with the first preset step size, it also includes: if the continuous input time of the driving voltage is determined The input time reaches the upper limit of the duration and the strength of the first blood pressure signal does not meet the preset condition, then after the second preset duration, the pulse voltage with the second frequency and the fourth amplitude is input to the stimulation coil and the input lasts The upper limit of time is used to make the magnetic field generated by the stimulating coil stimulate the motor cortex of the brain to twitch, the second frequency is the upper limit of frequency, and the fourth amplitude is the upper limit of voltage.
具体地，若驱动电压的持续输入时间达到持续时间上限值的条件下，大脑运动皮层还没有发生抽搐，则在保证人体承受内使用设备的最大输出值，使大脑运动皮层抽搐，其中，频率上限值为100Hz、电压上限值为储能电容的最大输出电压、驱动电压输入至刺激线圈的持续时间上限值为10秒。Specifically, if the continuous input time of the driving voltage reaches the upper limit value of the duration, and the motor cortex of the brain has not twitched, then the maximum output value of the device is used to make the motor cortex of the brain twitch while ensuring that the human body can bear it. The upper limit value is 100 Hz, the upper limit value of the voltage is the maximum output voltage of the energy storage capacitor, and the upper limit value of the duration of the driving voltage input to the stimulation coil is 10 seconds.
基于以上实施例，确定第一电压值，包括：逐一将频率为50Hz的第一测试脉冲电压输入至刺激线圈，每一输入到刺激线圈的第一测试脉冲电压持续5个脉冲，后一第一测试脉冲电压的振幅基于前一第一测试脉冲电压的振幅以第二预设步长增加；在每次将第一测试脉冲电压输入至刺激线圈后，获取第一测试脉冲电压输入至刺激线圈，以使刺激线圈所产生的磁场刺激大脑运动皮层后的复合肌电信号，直至确定复合肌电信号的最大值超过第一预设值；将复合肌电信号的最大值超过第一预设值时对应的第一测试脉冲电压的振幅作为第一电压值。Based on the above embodiment, determining the first voltage value includes: inputting the first test pulse voltage with a frequency of 50 Hz to the stimulating coil one by one, each of the first test pulse voltages input to the stimulating coil lasts for 5 pulses, and the next first The amplitude of the test pulse voltage is increased by a second preset step based on the amplitude of the previous first test pulse voltage; after each time the first test pulse voltage is input to the stimulation coil, the first test pulse voltage is obtained and input to the stimulation coil, So that the magnetic field produced by the stimulating coil stimulates the composite myoelectric signal after the motor cortex of the brain until it is determined that the maximum value of the composite myoelectric signal exceeds the first preset value; when the maximum value of the composite myoelectric signal exceeds the first preset value The amplitude of the corresponding first test pulse voltage is used as the first voltage value.
具体地，第一电压值由逐一输入到刺激线圈的第一测试脉冲电压来确定，其中，第一测试脉冲电压的频率为50Hz，持续5个脉冲，并且后一第一测试脉冲电压的振幅基于前一第一测试脉冲电压的振幅以第二预设步长增加，第二预设步长可按照储能电容的最大输出电压的百分比计，第一个输入至刺激线圈的第一测试脉冲电压的振幅为储能电容的最大输出电压的20％，将第一测试脉冲电压输入至刺激线圈后，获取第一测试脉冲电压输入至刺激线圈所产生的磁场刺激大脑运动皮层后的复合肌电信号，复合肌电信号可由如图2的检测仪器中7中的肌电图仪来测定，如果复合肌电信号的最大值未超过第一预设值，该第一预设值可设为50uV，则说明此时的第一测试脉冲电压输入到刺激线圈后产生的磁场所具有的刺激强度未达到运动阈值，则按第二预设步长增加第一测试脉冲电压的振幅，第二预设步长可设为储能电容的最大输出电压的5％，并重复上述过程，直至测试到的复合肌电信号的最大值超过第一预设值，将复合肌电信号的最大值超过第一预设值时对应的第一测试脉冲电压的振幅作为第一电压值。Specifically, the first voltage value is determined by the first test pulse voltage input to the stimulation coil one by one, wherein the frequency of the first test pulse voltage is 50 Hz and lasts for 5 pulses, and the amplitude of the latter first test pulse voltage is based on The amplitude of the previous first test pulse voltage increases with a second preset step size. The second preset step size can be calculated according to the percentage of the maximum output voltage of the energy storage capacitor. The first test pulse voltage input to the stimulation coil The amplitude is 20% of the maximum output voltage of the energy storage capacitor. After the first test pulse voltage is input to the stimulation coil, obtain the composite electromyography signal after the magnetic field generated by the first test pulse voltage input to the stimulation coil stimulates the brain motor cortex , the composite electromyographic signal can be measured by the electromyographic instrument in 7 in the detection instrument as shown in Figure 2, if the maximum value of the composite electromyographic signal does not exceed the first preset value, the first preset value can be set to 50uV, Then it shows that the stimulation intensity of the magnetic field generated after the first test pulse voltage is input to the stimulation coil at this time has not reached the motion threshold, then the amplitude of the first test pulse voltage is increased according to the second preset step length, and the second preset step The length can be set as 5% of the maximum output voltage of the energy storage capacitor, and repeat the above process until the maximum value of the composite electromyographic signal detected exceeds the first preset value, and the maximum value of the composite electromyographic signal exceeds the first preset value. The amplitude of the corresponding first test pulse voltage when setting the value is taken as the first voltage value.
基于以上实施例，根据第一电压值，确定第一频率，包括：逐一将具有第一振幅的第二测试脉冲电压输入至刺激线圈，每一输入到刺激线圈的第二测试脉冲电压持续输入第四预设时长，后一第二测试脉冲电压的频率基于前一第二测试脉冲电压的频率以第三预设步长增加；在每次将第二测试脉冲电压输入至刺激线圈后，获取第二测试脉冲电压输入至刺激线圈，以使刺激线圈所产生的磁场刺激大脑运动皮层后的第二血压信号，直至确定第二血压信号的最大值超过第二预设值；将第二血压信号的最大值超过第二预设值时对应的第二测试脉冲电压的频率作为第一频率。Based on the above embodiment, according to the first voltage value, determining the first frequency includes: inputting the second test pulse voltage with the first amplitude to the stimulation coil one by one, and each second test pulse voltage input to the stimulation coil is continuously input into the second test pulse voltage. Four preset durations, the frequency of the latter second test pulse voltage increases with a third preset step based on the frequency of the previous second test pulse voltage; after each time the second test pulse voltage is input to the stimulating coil, the second test pulse voltage is obtained The second test pulse voltage is input to the stimulating coil, so that the magnetic field generated by the stimulating coil stimulates the second blood pressure signal after the motor cortex of the brain, until it is determined that the maximum value of the second blood pressure signal exceeds the second preset value; The frequency corresponding to the second test pulse voltage when the maximum value exceeds the second preset value is used as the first frequency.
具体地，逐一将具有第一振幅的第二测试脉冲电压输入至刺激线圈，第一振幅为第一电压值的两倍，每一输入到刺激线圈的第二测试脉冲电压持续输入第四预设时长，该第二测试脉冲电压可由如图2所示的装置生成，其中，第四预设时长可设为6秒，后一第二测试脉冲电压的频率基于前一第二测试脉冲电压的频率以第三预设步长增加，其中，第一个第二测试脉冲电压的频率为20Hz，第三预设步长可设为10Hz；在每次将第二测试脉冲电压输入至刺激线圈后，获取第二测试脉冲电压输入至刺激线圈所产生的磁场刺激大脑运动皮层后的第二血压信号，其中，第二血压信号可由如图2的检测仪器中7中的血压计来测定，直至确定第二血压信号的最大值超过第二预设值，其中，第二预设值可根据历史数据来确定；将第二血压信号的最大值超过第二预设值时对应的第二测试脉冲电压的频率作为第一频率。Specifically, the second test pulse voltage with the first amplitude is input to the stimulation coil one by one, the first amplitude is twice the value of the first voltage, and each second test pulse voltage input to the stimulation coil is continuously input into the fourth preset duration, the second test pulse voltage can be generated by the device shown in Figure 2, wherein the fourth preset duration can be set to 6 seconds, the frequency of the latter second test pulse voltage is based on the frequency of the previous second test pulse voltage Increase with a third preset step size, wherein the frequency of the first second test pulse voltage is 20Hz, and the third preset step size can be set to 10Hz; after each second test pulse voltage is input to the stimulation coil, Obtain the second blood pressure signal after the second test pulse voltage is input to the magnetic field generated by the stimulating coil to stimulate the cerebral motor cortex, wherein the second blood pressure signal can be measured by the sphygmomanometer in 7 in the detection instrument as shown in Figure 2 until the second blood pressure signal is determined The maximum value of the second blood pressure signal exceeds the second preset value, wherein the second preset value can be determined according to historical data; when the maximum value of the second blood pressure signal exceeds the second preset value, the corresponding second test pulse voltage frequency as the first frequency.
最后说明的是：以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。Finally, it is noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than limiting them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it still can The technical solutions described in the foregoing embodiments are modified, or some of the technical features are equivalently replaced; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.
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Application publication date: 20190503 Assignee: Xinxiang Siwei Brain Science Research Institute Co.,Ltd. Assignor: XINXIANG MEDICAL University Contract record no.: X2024980044055 Denomination of invention: A method of stimulating seizures in the motor cortex of the brain Granted publication date: 20230512 License type: Open License Record date: 20241230 |