CN109700877A - A kind of anti acne of traditional Chinese medicine liquid and its preparation method and application - Google Patents
A kind of anti acne of traditional Chinese medicine liquid and its preparation method and application Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000000284 extract Substances 0.000 claims abstract description 50
- 206010000496 acne Diseases 0.000 claims abstract description 49
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Abstract
The invention discloses a kind of anti acne of traditional Chinese medicine liquid, the cork tree extract of Fructus Kochiae extract, 4-6g/L containing 6-12g/L and the Rhizoma Chuanxiong extract of 4-8g/L.The anti acne of traditional Chinese medicine liquid has very strong antipruritic anti-inflammatory effects, sense of discomfort caused by capable of effectively avoiding acne from itching sore.The invention also discloses a kind of preparation methods of anti acne of traditional Chinese medicine liquid, and process is simple, and operational safety is high, are suitble to industrialized production.The present invention discloses a kind of acne eliminating cream again, and product form is mild ingredient, non-stimulated to skin, fast and safely can effectively dispel comedo and acne, and acne print maintenance effect is good.Also a kind of preparation method of acne eliminating cream of the present invention, process is simple, and operational safety is high, is suitble to industrialized production.
Description
Technical field
The present invention relates to technical field of skin care more particularly to a kind of anti acne of traditional Chinese medicine liquid and its preparation method and application.
Background technique
Currently, many medicinal product for resolving poxes have all used the ingredients such as hormone, antibiotic, although these ingredient anti-acne effects are not
Mistake, but that there are irritations is big, easily causes skin to the drug resistance of Propiobacterium, therefore safety is much queried.And it makes up
Product relevant laws and regulations in product for resolving poxes clearly stipulate that forbid to add the unauthorized substances such as hormone, antibiotic.And it can be in cosmetics
The disadvantages of acne-removing object used, such as azelaic acid, tartaric acid etc., it is big that there is also irritations, and side effect is obvious, and current market
On product for resolving poxes, anti-acne effect is more focused on, and pay close attention to seldom antipruritic and later period acne print maintenance effect, so that patient
Comfort is poor during anti-acne, and there are certain damages for rear skin.Therefore, before guaranteeing to meet regulation and safety
It puts, develops a significant effect, it is curative for effect, with high safety and experience sense, rear product for resolving poxes without side-effects,
It is great for anti-acne market significance.
On the other hand, Chinese herbal medicine is long in the applicating history of China, and because its is highly-safe, few side effects, etiological treatment
The advantages that significant is big well-established.This concept of natural herb anti-acne skin care item, meets the shield of current safety, validity
Skin idea.In addition, fermentation raw material is more extensive in cosmetic applications, this tunning one with the development of genetic engineering
As be micromolecule polypeptide, wherein have a kind of polypeptide can dermal region play anti-acne effect.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of anti acne of traditional Chinese medicine liquid, have very
Strong antipruritic anti-inflammatory effects, sense of discomfort caused by capable of effectively avoiding acne from itching sore.
The second object of the present invention is to provide a kind of preparation method of anti acne of traditional Chinese medicine liquid, and process is simple, operational safety
Height is suitble to industrialized production.
The third object of the present invention is to provide a kind of acne eliminating cream, and product form is mild ingredient, non-stimulated to skin,
Comedo and acne fast and safely can be effectively dispelled, and acne print maintenance effect is good.
The fourth object of the present invention is to provide a kind of preparation method of acne eliminating cream, and process is simple, and operational safety is high, fits
Close industrialized production.
An object of the present invention adopts the following technical scheme that realization:
A kind of anti acne of traditional Chinese medicine liquid, the cork tree extract of Fructus Kochiae extract, 4-6g/L containing 6-12g/L and 4-8g/L's
Rhizoma Chuanxiong extract.
The second object of the present invention adopts the following technical scheme that realization:
A kind of preparation method of anti acne of traditional Chinese medicine liquid, comprising:
Drying steps: the fruit of summer cypress of 2-3kg, 2-3kg cork tree, 1-2kg Rhizoma Chuanxiong are wrapped up in the gauze respectively, are placed in 50-
Dry 12-24h in 60 DEG C of insulating boxs obtains the dry packet of the fruit of summer cypress, the dry packet of cork tree and the dry packet of Rhizoma Chuanxiong；
First concentration step: 90kg purified water is placed in extraction concentration unit, 90-95 DEG C is heated to, by the summer cypress
The dry packet of son, the dry packet of cork tree and the dry packet of Rhizoma Chuanxiong are added in the concentration tank for extracting concentration unit, and reflowing extracts 2-4h, when
When scale liquid level in concentration tank is 73-80kg, 60-70 DEG C is cooled the temperature to, continues that 4-8h is concentrated, is carved when liquid level reaches 50kg
When spending liquid level, concentration is completed.
It further, further include secondary concentration step: after the completion of first concentration step, as liquid level does not reach 50kg scale also
Liquid level then carries out secondary concentration, and the operating procedure of secondary concentration is identical as the operating procedure being concentrated for the first time, until liquid level reaches
To 50kg scale liquid level, concentration is completed.
The third object of the present invention adopts the following technical scheme that realization:
A kind of acne eliminating cream, including 9-28 parts of oil-phase component；2.3-6.3 parts of anti-corrosion composition；Antipruritic anti-inflammation components 12.51-
33.5 parts；Ingredient 1.8-2.2 parts of thickening；2.61-8 parts of anti-acne synergistic component；Purified water, surplus；The dosage summation of mentioned component
It is 100 parts；Wherein, the antipruritic anti-inflammation components include anti acne of traditional Chinese medicine liquid described in claim 1.
Further, the oil-phase component includes 1-3 parts of cetostearyl alcohol；The pure and mild cetearyl glucoside of cetearyl alcohol
0.5-3 parts of mixture；1-4 parts of caprylic/capric triglyceride；2-8 parts of (thylhexoic acid) ester of glycerol three；Dimethyl silicone polymer
2-10 parts；0.5-2 parts of mixture of stearine and PEG-100 stearate；
The anti-corrosion composition includes 0.1-0.2 parts of methyl hydroxybenzoate；0.1-0.2 parts of Nipasol；2-6 parts of 1,3 butylene glycol；
The antipruritic anti-inflammation components include the mixture 0.5-2 of Laurocapram, Cremophor RH40 and propylene glycol
Part；0.5-2 parts of the mixture of tocopherol, Cremophor RH40 and propylene glycol；EDTA-2NA0.01-0.1 parts；The anti-acne
10-30 parts of Chinese medicine liquid；
The thickening ingredient includes hydroxy-ethyl acrylate/1-2 parts of sodium acryloyldimethyl taurate copolymers；Acrylic acid
0.2-0.8 parts of the mixture of sodium/sodium acryloyldimethyl taurate copolymers, isohexadecane and Polyoxyethylene Sorbitan Monooleate；
The anti-acne synergistic component includes 0.1-1 parts of ethyl alcohol；0.01-0.1 parts of borneol；1-5 parts of olea europaea fruit extract；Water
Poplar acid, dextrin, 0.5-2 parts of mixture of xanthan gum and amylopectin；Fermentation of bacillus product, water, propylene glycol and 1,2- oneself
0.1-0.8 parts of the mixture of glycol.
Further, in the oil-phase component, the mixture of the pure and mild cetearyl glucoside of cetearyl alcohol is by Guangzhou
Hundred Hao Bo Co., Ltd, city provides, and product name is MONTANOV 68；Stearine and PEG-100 stearate it is mixed
It closes object to be provided by hundred Hao Bo Co., Ltd of Guangzhou, product name Simulsol165；
In the antipruritic anti-inflammation components, the mixture of Laurocapram, Cremophor RH40 and propylene glycol is by wide
State city adds Zhong Rong trade Co., Ltd to provide, and product name is water-soluble azone；Tocopherol, Cremophor RH40 and propylene glycol
Mixture by Guangzhou add Zhong Rong trade Co., Ltd provide, product name be water soluble vitamin E；
In the thickening ingredient, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers are good by Guangzhou hundred
Rich Co., Ltd provides, product name EMT10；Sodium acrylate/sodium acryloyldimethyl taurate copolymers, isohexadecane and
The mixture of Polyoxyethylene Sorbitan Monooleate is provided by hundred Hao Bo Co., Ltd of Guangzhou, and product name is SIMULGEL EG；
In the anti-acne synergistic component, salicylic acid, dextrin, xanthan gum and amylopectin mixture nangzan is converged by Guangzhou
Object Science and Technology Ltd. provides, and product name is BIOGENIC SA200；Fermentation of bacillus product, water, propylene glycol and 1,2-
The mixture of hexylene glycol is provided by Beijing Tai Kang Biotechnology Co., Ltd, trade name antibacterial peptide liquid.
Further, including 17 parts of oil-phase component；4.3 parts of anti-corrosion composition；22.05 parts of antipruritic anti-inflammation components；Thicken ingredient 2
Part；5.05 parts of anti-acne synergistic component；49.6 parts of purified water；Wherein, the fruit of summer cypress that the anti acne of traditional Chinese medicine liquid contains 10g/L extracts
Object, the cork tree extract of 5g/L and the Rhizoma Chuanxiong extract of 5g/L.
Further, including 17 parts of oil-phase component；4.3 parts of anti-corrosion composition；22.05 parts of antipruritic anti-inflammation components；Thicken ingredient 2
Part；5.05 parts of anti-acne synergistic component；49.6 parts of purified water；Wherein, the fruit of summer cypress that the anti acne of traditional Chinese medicine liquid contains 12g/L extracts
Object, the cork tree extract of 6g/L and the Rhizoma Chuanxiong extract of 8g/L.
Further, including 17 parts of oil-phase component；4.3 parts of anti-corrosion composition；22.05 parts of antipruritic anti-inflammation components；Thicken ingredient 2
Part；5.35 parts of anti-acne synergistic component；49.3 parts of purified water；Wherein, the fruit of summer cypress that the anti acne of traditional Chinese medicine liquid contains 12g/L extracts
Object, the cork tree extract of 6g/L and the Rhizoma Chuanxiong extract of 8g/L.
The fourth object of the present invention adopts the following technical scheme that realization:
A kind of preparation method of acne eliminating cream, comprising:
Anti-corrosion composition pre-treatment step: the methyl hydroxybenzoate of formula ratio and Nipasol are heated to 80-85 DEG C, are then dissolved in
In the 1,3-BDO of formula ratio, anti-corrosion composition is obtained；
Anti-acne synergistic component pre-treatment step: the borneol of formula ratio is dissolved in the ethyl alcohol of formula ratio, the oily olive of formula ratio
Olive berry extract is dissolved in 5-10 parts of purified waters, the salicylic acid of formula ratio, dextrin, xanthan gum and amylopectin mixture be dissolved in
In the purified water of surplus；The fermentation of bacillus product of formula ratio, water, the mixture of propylene glycol and 1,2- hexylene glycol are individually placed
It is spare；
Anti acne of traditional Chinese medicine liquid preparation step: the fruit of summer cypress of 2-3kg, 2-3kg cork tree, 1-2kg Rhizoma Chuanxiong are wrapped in gauze respectively
In, it is placed in 50-60 DEG C of insulating box dry 12-24h, obtains the dry packet of the fruit of summer cypress, the dry packet of cork tree and the dry packet of Rhizoma Chuanxiong；Then
90kg purified water is placed in extraction concentration unit, is heated to 90-95 DEG C, by the dry packet of the fruit of summer cypress, the dry packet of cork tree and
The dry packet of Rhizoma Chuanxiong is added in the concentration tank for extracting concentration unit to be concentrated for the first time, and reflowing extracts 2-4h, when in concentration tank
Scale liquid level be 73-80kg when, cool the temperature to 60-70 DEG C, continue be concentrated 4-8h, when liquid level reaches 50kg scale liquid level
When, concentration is completed；If liquid level does not reach 50kg scale liquid level also, then secondary concentration, the operating procedure of secondary concentration and institute are carried out
It is identical to state the operating procedure being concentrated for the first time, until liquid level reaches 50kg scale liquid level, obtains anti acne of traditional Chinese medicine liquid；
Heating stepses: the oil-phase component of formula ratio is sequentially added in emulsification oil cauldron, is heated to 80-85 DEG C, setting
Mixing speed is 500-1000rpm, and stirring heat preservation 20-40min stirs evenly dissolution；By the antipruritic anti-inflammatory of formula ratio at
Divide and sequentially add in emulsification kettle, be stirred and heated to 80-85 DEG C, setting mixing speed is 600-1000rpm, stirs 20-
40min, then the pretreated anti-corrosion composition is added in heat preservation, and setting mixing speed is 600-1000rpm, stirs 20-
40min；
Mixing step: the material in the emulsification kettle is pumped into emulsification main cooker, homogenizer is opened, homogeneous speed is set
For 2000-2500rpm, homogeneous 3-6min；It is then shut off homogenizer, opens blender, setting mixing speed is 40-60rpm,
The material of the emulsification oil cauldron is pumped into the emulsification main cooker in the case where stirring, vacuum is opened, closes blender, is opened equal
Matter device, setting homogeneous speed are 2000-2500rpm, homogeneous 4-8min, are then shut off homogenizer, open blender, setting stirring
Speed is 40-80rpm, stirs 40-60min, opens vacuum defoaming, stirs evenly dissolution；Then, when being cooled to 70 DEG C, successively
It being added the thickening ingredient, closes blender, open homogenizer, setting homogeneous speed is 2000-2500rpm, homogeneous 3-6min,
It is then shut off homogenizer, opens blender, 40-60min is stirred, continues cool to 45 DEG C, is sequentially added pretreated described
Anti-acne synergistic component, setting mixing speed be 40-60rpm, stir 30-50min, until stir evenly dissolution to get.
Compared with prior art, the beneficial effects of the present invention are:
(1) anti acne of traditional Chinese medicine liquid provided by the present invention has very strong antipruritic anti-inflammatory effects, effectively acne can be avoided to send out
Itch it is sore caused by sense of discomfort.
(2) preparation method of anti acne of traditional Chinese medicine liquid provided by the present invention, process is simple, and operational safety is high, is suitble to industry
Metaplasia produces.
(3) Whelk-eliminating paste provided by the present invention is a with three kinds of polypeptide, Chinese herbal medicine and natural plant extracts ingredients
The product of anti-acne is cooperateed with, is free of stimulating component (such as hormone, antibiotic, tartaric acid, azelaic acid), nothing non-stimulated to skin
Toxic side effect has the antibacterial effect of antipruritic anti-acne, anti-inflammatory, can effectively decompose the toxin of dark sore bacterium, reach quick anti-acne
Effect.
(4) preparation method of Whelk-eliminating paste provided by the present invention, process is simple, and operational safety is high, is suitble to industry metaplasia
It produces.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
A kind of anti acne of traditional Chinese medicine liquid, the cork tree extract of Fructus Kochiae extract, 4-6g/L containing 6-12g/L and 4-8g/L's
Rhizoma Chuanxiong extract.
Anti acne of traditional Chinese medicine liquid provided by the present invention has very strong antipruritic anti-inflammatory effects, effectively acne can be avoided to itch
Sense of discomfort caused by sore.
A kind of preparation method of anti acne of traditional Chinese medicine liquid, comprising:
Drying steps: the fruit of summer cypress of 2-3kg, 2-3kg cork tree, 1-2kg Rhizoma Chuanxiong are wrapped up in the gauze respectively, are placed in 50-
Dry 12-24h in 60 DEG C of insulating boxs, then weighing records respectively, obtains the dry packet of the fruit of summer cypress, the dry packet of cork tree and Rhizoma Chuanxiong drying
Packet；
First concentration step: 90kg purified water is placed in extraction concentration unit, 90-95 DEG C is heated to, the fruit of summer cypress is done
The dry packet of dry packet, cork tree and the dry packet of Rhizoma Chuanxiong are added in the concentration tank for extracting concentration unit, and reflowing extracts 2-4h, works as concentration
When scale liquid level in tank is 73-80kg (preferably 76kg), 60-70 DEG C is cooled the temperature to, continues that 4-8h is concentrated, works as liquid level
When reaching 50kg scale liquid level, concentration is completed.
Concentration calculation step: after the completion of concentration, taking out the Chinese medicine of package in the gauze, drain until no longer dropping liquid, will
It is placed in 80-90 DEG C of insulating box dry 12-24h, and then weighing records respectively, the front and back difference with the weighing in drying steps
The as leaching quality of the Chinese medicine, then be the mass fraction of effective component of chinese medicine divided by obtained Chinese medicine liquid total weight, finally
Obtain Fructus Kochiae extract, the cork tree extract of 4-6g/L and the Rhizoma Chuanxiong of 4-8g/L containing effective composition quality score 6-12g/L
The anti acne of traditional Chinese medicine liquid of extract.
It further include secondary concentration step as preferred embodiment: after the completion of first concentration step, as liquid level does not reach also
To 50kg scale liquid level, then secondary concentration being carried out, the operating procedure of secondary concentration is identical as the operating procedure being concentrated for the first time, until
Liquid level reaches 50kg scale liquid level, and concentration is completed.
The preparation method of anti acne of traditional Chinese medicine liquid provided by the present invention, process is simple, and operational safety is high, is suitble to industry metaplasia
It produces.
A kind of acne eliminating cream, including 9-28 parts of oil-phase component；2.3-6.3 parts of anti-corrosion composition；Antipruritic anti-inflammation components 12.51-
33.5 parts；Ingredient 1.8-2.2 parts of thickening；2.61-8 parts of anti-acne synergistic component；Purified water, surplus；The dosage summation of mentioned component
It is 100 parts；Wherein, antipruritic anti-inflammation components include the anti acne of traditional Chinese medicine liquid of claim 1.
As preferred embodiment, oil-phase component includes 1-3 parts of cetostearyl alcohol；The pure and mild cetearyl of cetearyl alcohol
0.5-3 parts of the mixture of glucoside；1-4 parts of caprylic/capric triglyceride；2-8 parts of (thylhexoic acid) ester of glycerol three；Poly dimethyl
2-10 parts of siloxanes；0.5-2 parts of mixture of stearine and PEG-100 stearate；Anti-corrosion composition includes oxybenzene first
0.1-0.2 parts of ester；0.1-0.2 parts of Nipasol；2-6 parts of 1,3 butylene glycol；Antipruritic anti-inflammation components include Laurocapram, PEG-
0.5-2 parts of 40 rilanit specials and the mixture of propylene glycol；The mixture of tocopherol, Cremophor RH40 and propylene glycol
0.5-2 parts；EDTA-2NA0.01-0.1 parts；10-30 parts of anti acne of traditional Chinese medicine liquid；Thickening ingredient includes hydroxy-ethyl acrylate/acryloyl
- 2 parts of copolymer 1 of dimethyltaurine sodium；Sodium acrylate/sodium acryloyldimethyl taurate copolymers, isohexadecane and poly- mountain
0.2-0.8 parts of the mixture of pears alcohol ester -80；Anti-acne synergistic component includes 0.1-1 parts of ethyl alcohol；0.01-0.1 parts of borneol；Olive
1-5 parts of berry extract；Salicylic acid, dextrin, 0.5-2 parts of mixture of xanthan gum and amylopectin；Fermentation of bacillus product,
0.1-0.8 parts of the mixture of water, propylene glycol and 1,2- hexylene glycol.
Whelk-eliminating paste provided by the present invention, the anti acne of traditional Chinese medicine liquid in antipruritic anti-inflammation components, effective component are common for Chinese medicine
For antipruritic antimicrobial component, the metal ion-chelant in Chinese medicine can be avoided metal ion from influencing effective component, water by EDTA-2NA
Molten azone (mixture of osmanthus Azone, Cremophor RH40 and propylene glycol) can play the role of promoting infiltration, guarantee that antibacterial is stopped
Ingredient of itching effectively permeates, water soluble vitamin E (mixture of tocopherol (vitamin E), Cremophor RH40 and propylene glycol)
Antioxidation is played, four collective effects ensure that antipruritic antibacterial ingredient safely and effectively maximizes.
Whelk-eliminating paste provided by the present invention, solvent of the superfine alcohol (ethyl alcohol) as borneol in anti-acne synergistic component, borneol
The effect of Repercusion analgesia can be played, the effective component of olive essence HIDROX 12% are that olive (OLEA EUROPAEA) fruit mentions
Take object, wherein be rich in hydroxytyrosol, can effectively inhibit 5-LOX (5- lipoxidase) &COX (Cycloxygenase rejection ability, thus
PGs (prostaglandin) and inflammatory reaction are blocked, antibacterial anti-inflammatory is played the role of.BIOGENIC SA200 (salicylic acid, dextrin, Huang
The mixture of virgin rubber, amylopectin) it is package salicylic acid, irritation is easily led to for salicylic acid, utilizes dextrin, xanthan gum, branch
Chain starch wraps up salicylic acid, to both utilize its acne-removing, avoids its irritation further through slow releasing function.Antibacterial peptide
(fermentation of bacillus product, water, propylene glycol and 1, the mixture of 2- hexylene glycol) can effectively inhibit propionibacterium acnes and
Maintenance acne print is enough played the role of by stimulation collagen generation.
As preferred embodiment, in oil-phase component, the mixture of the pure and mild cetearyl glucoside of cetearyl alcohol
It is provided by hundred Hao Bo Co., Ltd of Guangzhou, product name is MONTANOV 68；Stearine and PEG-100 stearic acid
The mixture of ester is provided by hundred Hao Bo Co., Ltd of Guangzhou, and product name is Simulsol 165；In antipruritic anti-inflammation components,
The mixture of Laurocapram, Cremophor RH40 and propylene glycol adds Zhong Rong trade Co., Ltd to provide by Guangzhou, quotient
The name of an article is known as water-soluble azone；The mixture of tocopherol, Cremophor RH40 and propylene glycol adds middle banyan trade to have by Guangzhou
Limit company provides, and product name is water soluble vitamin E；In thickening ingredient, hydroxy-ethyl acrylate/acryloyldimethyl taurine
Sodium copolymer is provided by hundred Hao Bo Co., Ltd of Guangzhou, product name EMT10；Sodium acrylate/acryloyldimethyl ox sulphur
The mixture of sour sodium copolymer, isohexadecane and Polyoxyethylene Sorbitan Monooleate is provided by hundred Hao Bo Co., Ltd of Guangzhou, product name
For SIMULGEL EG；In anti-acne synergistic component, salicylic acid, dextrin, xanthan gum and amylopectin mixture converged by Guangzhou it is bright
Biotechnology Co., Ltd provides, and product name is BIOGENIC SA200；Fermentation of bacillus product, water, propylene glycol and 1,
The mixture of 2- hexylene glycol is provided by Beijing Tai Kang Biotechnology Co., Ltd, trade name antibacterial peptide liquid.
BIOGENIC SA200 is a kind of package salicylic acid, so that salicylic acid is water-soluble, contains 40% pure salicylic acid, can obtain pure
Salicylic acid content is up to 15% transparent aqueous solution；Can effectively quick anti-acne, remove old dead angle matter, glabrous skin and accelerate whitening
Effect.
Anti-acne treatment time is long at present, and hormone antibiotic usage is spread unchecked, and skin can be made to generate drug resistance, and has quite big
Side effect, and provided Whelk-eliminating paste of the invention is cooperateed with three kinds of polypeptide, Chinese herbal medicine and natural plant extracts ingredients
Anti-acne is free of stimulating component (such as hormone, antibiotic, tartaric acid, azelaic acid), non-stimulated to skin, has no toxic side effect, and has
The antibacterial effect of standby antipruritic anti-acne, anti-inflammatory, can effectively decompose the toxin of dark sore bacterium, have the function that quick anti-acne.Specifically:
(1) pH of product is 4.0-5.0, and viscosity is 10000-20000mPas (25 DEG C, No. 5 rotors, 20 turns/min),
Product form is mild ingredient, non-stimulated to skin, and acne print maintenance effect is good；
(2) pH value range of product is faintly acid, which can inhibit to inhibit the growth of propionibacterium acnes, accord with simultaneously
Close the requirement of skin faintly acid physiology；
(3) easy to use, it fast and safely can effectively dispel comedo and acne；
(4) traditional Chinese medicine ingredients in product have very powerful antipruritic anti-inflammatory effects, the sense of discomfort for avoiding acne from itching sore；
(5) antibacterial action of anti acne of traditional Chinese medicine liquid and olea europaea fruit extract is utilized, addition preservative as few as possible avoids
Stimulation allergic conditions are generated to impaired skin.
A kind of preparation method of acne eliminating cream, comprising:
Anti-corrosion composition pre-treatment step: the methyl hydroxybenzoate of formula ratio and Nipasol are heated to 80-85 DEG C, are then dissolved in
In the 1,3-BDO of formula ratio, anti-corrosion composition is obtained；
Anti-acne synergistic component pre-treatment step: the borneol of formula ratio is dissolved in the ethyl alcohol of formula ratio, the oily olive of formula ratio
Olive berry extract is dissolved in 5-10 parts of purified waters, the salicylic acid of formula ratio, dextrin, xanthan gum and amylopectin mixture be dissolved in
In the purified water of surplus；The fermentation of bacillus product of formula ratio, water, the mixture of propylene glycol and 1,2- hexylene glycol are individually placed
It is spare；
Anti acne of traditional Chinese medicine liquid preparation step: the fruit of summer cypress of 2-3kg, 2-3kg cork tree, 1-2kg Rhizoma Chuanxiong are wrapped in gauze respectively
In, it is placed in 50-60 DEG C of insulating box dry 12-24h, obtains the dry packet of the fruit of summer cypress, the dry packet of cork tree and the dry packet of Rhizoma Chuanxiong；Then
90kg purified water is placed in extraction concentration unit, is heated to 90-95 DEG C, by the dry packet of the fruit of summer cypress, the dry packet of cork tree and Rhizoma Chuanxiong
Dry packet is added in the concentration tank for extracting concentration unit and is concentrated for the first time, and reflowing extracts 2-4h, when the quarter in concentration tank
When degree liquid level is 73-80kg, 60-70 DEG C is cooled the temperature to, continues that 4-8h is concentrated, it is dense when liquid level reaches 50kg scale liquid level
Contracting is completed；If liquid level does not reach 50kg scale liquid level also, then secondary concentration, the operating procedure of secondary concentration and first concentration are carried out
Operating procedure it is identical, until liquid level reaches 50kg scale liquid level, obtain anti acne of traditional Chinese medicine liquid；
Heating stepses: the oil-phase component of formula ratio is sequentially added in emulsification oil cauldron, is heated to 80-85 DEG C, setting stirring
Speed is 500-1000rpm, and stirring heat preservation 20-40min stirs evenly dissolution；The antipruritic anti-inflammation components of formula ratio are successively added
Enter to emulsify in kettle, be stirred and heated to 80-85 DEG C, setting mixing speed is 600-1000rpm, stirs 20-40min, then protects
Pretreated anti-corrosion composition is added in temperature, and setting mixing speed is 600-1000rpm, stirs 20-40min；
Mixing step: will emulsify the material in kettle and be pumped into emulsification main cooker, open homogenizer, and setting homogeneous speed is
2000-2500rpm, homogeneous 3-6min；It is then shut off homogenizer, opens blender, setting mixing speed is 40-60rpm, is being stirred
The material for emulsifying oil cauldron is pumped into emulsification main cooker in the case where mixing, opens vacuum, closes blender, opens homogenizer, setting
Homogeneous speed is 2000-2500rpm, homogeneous 4-8min, is then shut off homogenizer, opens blender, and setting mixing speed is 40-
80rpm stirs 40-60min, opens vacuum defoaming, stirs evenly dissolution；Then, when being cooled to 70 DEG C, sequentially add thickening at
Point, blender is closed, homogenizer is opened, setting homogeneous speed is 2000-2500rpm, and homogeneous 3-6min is then shut off homogeneous
Device opens blender, stirs 40-60min, continues cool to 45 DEG C, sequentially add pretreated anti-acne synergistic component, is arranged
Mixing speed is 40-60rpm, stir 30-50min, until stir evenly dissolution to get.
The preparation method of Whelk-eliminating paste provided by the present invention, process is simple, and operational safety is high, is suitble to industrialized production.
It is specific embodiment of the present invention below, used raw material, equipment etc. remove special limit in the following embodiments
It can be obtained by buying pattern outside fixed.
Embodiment 1-6
A kind of Whelk-eliminating paste, is prepared in accordance with the following methods:
Material preparation step: preparing raw material includes oil-phase component, anti-corrosion composition, antipruritic anti-inflammation components, thickening ingredient, anti-acne synergy
Ingredient and purified water, wherein antipruritic anti-inflammation components include that (embodiment 1-6 raw materials used specifying information is detailed for anti acne of traditional Chinese medicine liquid
It is shown in Table 1-3)；
Anti-corrosion composition pre-treatment step: the methyl hydroxybenzoate of formula ratio and Nipasol are heated to 80-85 DEG C, are then dissolved in
In the 1,3-BDO of formula ratio, anti-corrosion composition is obtained；
Anti-acne synergistic component pre-treatment step: the borneol of formula ratio is dissolved in the ethyl alcohol of formula ratio, the oily olive of formula ratio
Olive berry extract is dissolved in 5-10 parts of purified waters, the salicylic acid of formula ratio, dextrin, xanthan gum and amylopectin mixture be dissolved in
In the purified water of surplus；The fermentation of bacillus product of formula ratio, water, the mixture of propylene glycol and 1,2- hexylene glycol are individually placed
It is spare；
Anti acne of traditional Chinese medicine liquid preparation step: by the fruit of summer cypress (KOCHIA SCOPARIA) extract, cork tree of formula ratio
(PHELLODENDRON AMURENSE) extract, Rhizoma Chuanxiong (LIGUSTICUM CHUANXIONG) extract are wrapped in yarn respectively
In cloth, dry 12-24h is placed in 50-60 DEG C of insulating box, and then weighing records respectively, and it is dry to obtain the dry packet of the fruit of summer cypress, cork tree
Packet and the dry packet of Rhizoma Chuanxiong；Then 90kg purified water is placed in extraction concentration unit, is heated to 90-95 DEG C, the fruit of summer cypress is dry
The dry packet of packet, cork tree and the dry packet of Rhizoma Chuanxiong are added in the concentration tank for extracting concentration unit and are concentrated for the first time, and reflowing is extracted
2-4h cools the temperature to 60-70 DEG C when the scale liquid level in concentration tank is about 76kg, continues that 4-8h is concentrated, when liquid level reaches
When 50kg scale liquid level, concentration is completed；If liquid level does not reach 50kg scale liquid level also, then secondary concentration is carried out, secondary concentration
Operating procedure is identical as the operating procedure being concentrated for the first time, until liquid level reaches 50kg scale liquid level, obtains anti acne of traditional Chinese medicine liquid；Concentration
After the completion, the Chinese medicine of package in the gauze is taken out, is drained until no longer dropping liquid, is placed it in dry in 80-90 DEG C of insulating box
12-24h, then weighing records respectively, is the leaching quality of the Chinese medicine with the front and back difference weighed when drying before concentration extraction,
It is again the mass fraction of effective component of chinese medicine divided by obtained Chinese medicine liquid total weight；
Heating stepses: the oil-phase component of formula ratio is sequentially added in emulsification oil cauldron, is heated to 80-85 DEG C, setting stirring
Speed is 500-1000rpm, and stirring heat preservation 20-40min stirs evenly dissolution；The antipruritic anti-inflammation components of formula ratio are successively added
Enter to emulsify in kettle, be stirred and heated to 80-85 DEG C, setting mixing speed is 600-1000rpm, stirs 20-40min, then protects
Pretreated anti-corrosion composition is added in temperature, and setting mixing speed is 600-1000rpm, stirs 20-40min；
Mixing step: will emulsify the material in kettle and be pumped into emulsification main cooker, open homogenizer, and setting homogeneous speed is
2000-2500rpm, homogeneous 3-6min；It is then shut off homogenizer, opens blender, setting mixing speed is 40-60rpm, is being stirred
The material for emulsifying oil cauldron is pumped into emulsification main cooker in the case where mixing, opens vacuum, closes blender, opens homogenizer, setting
Homogeneous speed is 2000-2500rpm, homogeneous 4-8min, is then shut off homogenizer, opens blender, and setting mixing speed is 40-
80rpm stirs 40-60min, opens vacuum defoaming, stirs evenly dissolution；Then, when being cooled to 70 DEG C, sequentially add thickening at
Point, blender is closed, homogenizer is opened, setting homogeneous speed is 2000-2500rpm, and homogeneous 3-6min is then shut off homogeneous
Device opens blender, stirs 40-60min, continues cool to 45 DEG C, sequentially add pretreated anti-acne synergistic component, is arranged
Mixing speed is 40-60rpm, stir 30-50min, until stir evenly dissolution to get.
The formula table of the acne eliminating cream of 1 embodiment 1-6 of table
The formula table of the acne eliminating cream of 2 embodiment 1-6 of table
The formula table of the anti acne of traditional Chinese medicine liquid of 3 embodiment 1-6 of table
Effect assessment and performance detection
1, pH and viscosity test
The acne eliminating cream that Example 1-5 is obtained, to its pH and viscosity (test condition: 25 DEG C, No. 5 rotors, 20 turns/min)
It is tested, test result see the table below 4.
The pH and viscosity results record sheet of the acne eliminating cream of 4 embodiment 1-4 of table
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| pH | 4.1 | 4.8 | 4.3 | 4.4 | 4.2 | 4.2 |
| Viscosity mPas | 12600 | 18500 | 15200 | 15800 | 16100 | 16300 |
It can be obtained from the record in table 4, the pH value range of the Whelk-eliminating paste of embodiment 1-6 is faintly acid, which can press down
System inhibits the growth of propionibacterium acnes, while meeting the requirement of skin faintly acid physiology.
2, it is formulated based on embodiment 1-3, is resisted cold to it, resistance to Thermal test, as a result can be passed through.Skin sensing examination
It has been shown that, 1 grease additive amount of embodiment is more, there is greasy feeling, and Oily experience sense is general；Embodiment 2 is slightly sticky thick, and skin sense is slightly
Difference；3 skin sense of embodiment can generally receive, therefore be formulated based on selection embodiment 3.On the basis of embodiment 3, it will dispel
Acne Chinese medicine liquid active constituent content is prepared as minimum, as embodiment 4；On the basis of embodiment 3, anti acne of traditional Chinese medicine liquid is had
Effective component content is prepared as peak, as embodiment 5；On the basis of embodiment 5, anti-acne peptide additive amount is promoted to highest
Value, as embodiment 6.
Selection closes light moderate acne patient totally 30, is divided into three groups, uses acne eliminating cream prepared by embodiment 4-6 respectively,
Once in the morning and once at night, it persistently uses 2 weeks, symptom eliminates when such as one week, is stopped using when continuing to using to 2 weeks.In treatment phase
It is observed three times, respectively treats third in the future, after a week, after two weeks.It is commented respectively for acne healing recovery extent
Valence, evaluation index is divided into acne or acne disappears, no pain or gargalesthesia, substantially without acne print skin lesion, non-stimulated allergic phenomena.Test
As a result 5 be see the table below:
The rear effect evaluation table of the acne eliminating cream of 5 embodiment 4-6 of table
Show that embodiment 4-6 has good therapeutic effect to acne from the record of table 5, embodiment 5 is dispelled by improving
The effective content mass fraction of acne Chinese medicine liquid, can be substantially reduced pain and gargalesthesia, show that it has the effect of anti-inflammatory anti-itch；It is real
Example 6 is applied by increasing the dosage of anti-acne peptide, the available good maintenance of healing stage skin lesion acne print, and without mistake in use process
Quick stimulation phenomenon.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of anti acne of traditional Chinese medicine liquid, which is characterized in that the cork tree extract of Fructus Kochiae extract, 4-6g/L containing 6-12g/L
With the Rhizoma Chuanxiong extract of 4-8g/L.
2. the preparation method of anti acne of traditional Chinese medicine liquid as described in claim 1 characterized by comprising
Drying steps: the fruit of summer cypress of 2-3kg, 2-3kg cork tree, 1-2kg Rhizoma Chuanxiong are wrapped up in the gauze respectively, are placed in 50-60 DEG C
Dry 12-24h in insulating box obtains the dry packet of the fruit of summer cypress, the dry packet of cork tree and the dry packet of Rhizoma Chuanxiong；
First concentration step: 90kg purified water is placed in extraction concentration unit, 90-95 DEG C is heated to, the fruit of summer cypress is done
The dry packet of dry packet, cork tree and the dry packet of Rhizoma Chuanxiong are added in the concentration tank for extracting concentration unit, and reflowing extracts 2-4h, works as concentration
When scale liquid level in tank is 73-80kg, 60-70 DEG C is cooled the temperature to, continues that 4-8h is concentrated, when liquid level reaches 50kg scale liquid
When position, concentration is completed.
3. the preparation method of anti acne of traditional Chinese medicine liquid as claimed in claim 2, which is characterized in that further include secondary concentration step: just
After the completion of secondary concentration step, if liquid level does not reach 50kg scale liquid level also, then secondary concentration, the operating procedure of secondary concentration are carried out
Identical as the operating procedure being concentrated for the first time, until liquid level reaches 50kg scale liquid level, concentration is completed.
4. a kind of acne eliminating cream, which is characterized in that including 9-28 parts of oil-phase component；2.3-6.3 parts of anti-corrosion composition；Antipruritic anti-inflammation components
12.51-33.5 parts；Ingredient 1.8-2.2 parts of thickening；2.61-8 parts of anti-acne synergistic component；Purified water, surplus；The use of mentioned component
Measuring summation is 100 parts；Wherein, the antipruritic anti-inflammation components include anti acne of traditional Chinese medicine liquid described in claim 1.
5. acne eliminating cream as claimed in claim 4, which is characterized in that the oil-phase component includes 1-3 parts of cetostearyl alcohol；Spermaceti
0.5-3 parts of stearyl alcohol and the mixture of cetearyl glucoside；1-4 parts of caprylic/capric triglyceride；Three (ethyl hexyl of glycerol
Acid) 2-8 parts of ester；2-10 parts of dimethyl silicone polymer；0.5-2 parts of mixture of stearine and PEG-100 stearate；
The anti-corrosion composition includes 0.1-0.2 parts of methyl hydroxybenzoate；0.1-0.2 parts of Nipasol；2-6 parts of 1,3 butylene glycol；
The antipruritic anti-inflammation components include 0.5-2 parts of mixture of Laurocapram, Cremophor RH40 and propylene glycol；It is raw
0.5-2 parts of mixture for educating phenol, Cremophor RH40 and propylene glycol；0.01-0.1 parts of EDTA-2NA；The anti acne of traditional Chinese medicine
10-30 parts of liquid；
The thickening ingredient includes hydroxy-ethyl acrylate/1-2 parts of sodium acryloyldimethyl taurate copolymers；Sodium acrylate/the third
0.2-0.8 parts of mixture of alkene acyl dimethyltaurine sodium copolymer, isohexadecane and Polyoxyethylene Sorbitan Monooleate；
The anti-acne synergistic component includes 0.1-1 parts of ethyl alcohol；0.01-0.1 parts of borneol；1-5 parts of olea europaea fruit extract；Bigcatkin willow
Acid, dextrin, 0.5-2 parts of mixture of xanthan gum and amylopectin；Fermentation of bacillus product, water, propylene glycol and 1,2- oneself two
0.1-0.8 parts of the mixture of alcohol.
6. acne eliminating cream as claimed in claim 5, which is characterized in that in the oil-phase component, the pure and mild spermaceti of cetearyl alcohol is hard
The mixture of aliphatic radical glucoside is provided by hundred Hao Bo Co., Ltd of Guangzhou, and product name is MONTANOV 68；Glycerol stearate
The mixture of ester and PEG-100 stearate is provided by hundred Hao Bo Co., Ltd of Guangzhou, and product name is Simulsol 165；
In the antipruritic anti-inflammation components, the mixture of Laurocapram, Cremophor RH40 and propylene glycol is by Guangzhou
Zhong Rong trade Co., Ltd is added to provide, product name is water-soluble azone；Tocopherol, Cremophor RH40 and propylene glycol it is mixed
It closes object and adds Zhong Rong trade Co., Ltd to provide by Guangzhou, product name is water soluble vitamin E；
In the thickening ingredient, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers are had by good win in Guangzhou hundred
Limit company provides, product name EMT10；Sodium acrylate/sodium acryloyldimethyl taurate copolymers, isohexadecane and poly- mountain
The mixture of pears alcohol ester -80 is provided by hundred Hao Bo Co., Ltd of Guangzhou, and product name is SIMULGEL EG；
In the anti-acne synergistic component, salicylic acid, dextrin, xanthan gum and amylopectin mixture bright biological section is converged by Guangzhou
Skill Co., Ltd provides, and product name is BIOGENIC SA200；Fermentation of bacillus product, water, propylene glycol and 1,2- oneself two
The mixture of alcohol is provided by Beijing Tai Kang Biotechnology Co., Ltd, trade name antibacterial peptide liquid.
7. acne eliminating cream as claimed in claim 4, which is characterized in that including 17 parts of oil-phase component；4.3 parts of anti-corrosion composition；It is antipruritic
22.05 parts of anti-inflammation components；2 parts of ingredient of thickening；5.05 parts of anti-acne synergistic component；49.6 parts of purified water；Wherein, the anti acne of traditional Chinese medicine
Liquid contains the Fructus Kochiae extract of 10g/L, the cork tree extract of 5g/L and the Rhizoma Chuanxiong extract of 5g/L.
8. acne eliminating cream as claimed in claim 4, which is characterized in that including 17 parts of oil-phase component；4.3 parts of anti-corrosion composition；It is antipruritic
22.05 parts of anti-inflammation components；2 parts of ingredient of thickening；5.05 parts of anti-acne synergistic component；49.6 parts of purified water；Wherein, the anti acne of traditional Chinese medicine
Liquid contains the Fructus Kochiae extract of 12g/L, the cork tree extract of 6g/L and the Rhizoma Chuanxiong extract of 8g/L.
9. acne eliminating cream as claimed in claim 4, which is characterized in that including 17 parts of oil-phase component；4.3 parts of anti-corrosion composition；It is antipruritic
22.05 parts of anti-inflammation components；2 parts of ingredient of thickening；5.35 parts of anti-acne synergistic component；49.3 parts of purified water；Wherein, the anti acne of traditional Chinese medicine
Liquid contains the Fructus Kochiae extract of 12g/L, the cork tree extract of 6g/L and the Rhizoma Chuanxiong extract of 8g/L.
10. a kind of preparation method of such as described in any item acne eliminating creams of claim 5-9 characterized by comprising
Anti-corrosion composition pre-treatment step: the methyl hydroxybenzoate of formula ratio and Nipasol are heated to 80-85 DEG C, are then dissolved in formula
In the 1,3-BDO of amount, anti-corrosion composition is obtained；
Anti-acne synergistic component pre-treatment step: the borneol of formula ratio is dissolved in the ethyl alcohol of formula ratio, the olea europaea fruit of formula ratio
Extract is dissolved in 5-10 parts of purified waters, the salicylic acid of formula ratio, dextrin, xanthan gum and amylopectin mixture be dissolved in surplus
Purified water in；The fermentation of bacillus product of formula ratio, water, the mixture of propylene glycol and 1,2- hexylene glycol are individually placed standby
With；
Anti acne of traditional Chinese medicine liquid preparation step: the fruit of summer cypress of 2-3kg, 2-3kg cork tree, 1-2kg Rhizoma Chuanxiong are wrapped up in the gauze respectively, set
The dry 12-24h in 50-60 DEG C of insulating box obtains the dry packet of the fruit of summer cypress, the dry packet of cork tree and the dry packet of Rhizoma Chuanxiong；Then will
90kg purified water is placed in extraction concentration unit, is heated to 90-95 DEG C, by the dry packet of the fruit of summer cypress, the dry packet of cork tree and river
The dry packet of rhizome of chuanxiong is added in the concentration tank for extracting concentration unit to be concentrated for the first time, and reflowing extracts 2-4h, when in concentration tank
When scale liquid level is 73-80kg, 60-70 DEG C is cooled the temperature to, continues that 4-8h is concentrated, when liquid level reaches 50kg scale liquid level,
Concentration is completed；If liquid level does not reach 50kg scale liquid level also, then carry out secondary concentration, the operating procedure of secondary concentration and it is described just
The operating procedure of secondary concentration is identical, until liquid level reaches 50kg scale liquid level, obtains anti acne of traditional Chinese medicine liquid；
Heating stepses: the oil-phase component of formula ratio is sequentially added in emulsification oil cauldron, is heated to 80-85 DEG C, setting stirring
Speed is 500-1000rpm, and stirring heat preservation 20-40min stirs evenly dissolution；By the antipruritic anti-inflammation components of formula ratio according to
In secondary addition emulsification kettle, it is stirred and heated to 80-85 DEG C, setting mixing speed is 600-1000rpm, stirs 20-40min, so
The pretreated anti-corrosion composition is added in heat preservation afterwards, and setting mixing speed is 600-1000rpm, stirs 20-40min；
Mixing step: the material in the emulsification kettle is pumped into emulsification main cooker, opens homogenizer, and setting homogeneous speed is
2000-2500rpm, homogeneous 3-6min；It is then shut off homogenizer, opens blender, setting mixing speed is 40-60rpm, is being stirred
The material of the emulsification oil cauldron is pumped into the emulsification main cooker in the case where mixing, vacuum is opened, closes blender, open homogeneous
Device, setting homogeneous speed are 2000-2500rpm, homogeneous 4-8min, are then shut off homogenizer, open blender, setting stirring speed
Degree is 40-80rpm, stirs 40-60min, opens vacuum defoaming, stirs evenly dissolution；Then, when being cooled to 70 DEG C, successively plus
Enter the thickening ingredient, close blender, open homogenizer, setting homogeneous speed is 2000-2500rpm, homogeneous 3-6min, so
After close homogenizer, open blender, stir 40-60min, continue cool to 45 DEG C, sequentially add pretreated described dispel
Acne synergistic component, setting mixing speed be 40-60rpm, stir 30-50min, until stir evenly dissolution to get.
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