CN109688814A - Microbicide composition - Google Patents
Microbicide composition Download PDFInfo
- Publication number
- CN109688814A CN109688814A CN201780055758.7A CN201780055758A CN109688814A CN 109688814 A CN109688814 A CN 109688814A CN 201780055758 A CN201780055758 A CN 201780055758A CN 109688814 A CN109688814 A CN 109688814A
- Authority
- CN
- China
- Prior art keywords
- dipropylene glycol
- phenyl ether
- glycol phenyl
- phenoxetol
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/14—Ethers
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a synergistic microbicidal composition having two components: phenoxyethanol and dipropylene glycol phenyl ether, and a method of inhibiting microbial growth using the synergistic microbicidal composition.
Description
The present invention relates to the Synergistic microbicidal compositions containing 2- phenoxetol and dipropylene glycol phenyl ether.
It is disclosed in U.S. Patent number 4,295,932 comprising 5- chloro-2-methyl isothiazoline -3- ketone, 2- methyl-isothiazol
The composition of quinoline -3- ketone and non-ionic dispersing agent.The composition contains 5- chloro-2-methyl isothiazoline -3- ketone and 2- methyl
3: 1 mixtures of isothiazoline -3- ketone and the copolymer of ethylene oxide and propylene oxide, the copolymer seem have with
The identical composition of PLURONIC L61 or TERGITOL L61 dispersing agent.However, it is necessary to which there is association for various microbial strains
With the combination of active microbicide, to provide effective control to microorganism.In addition, being needed for environment and economic benefits
It to include such combination of low-level individual microbicides.Such microbicide is to provide by problems solved by the invention
Synergistic combination.
Summary of the invention
The present invention relates to a kind of synergistic microbicidal compositions comprising phenoxetol and dipropylene glycol phenyl ether.
The invention further relates to a kind of method for inhibiting the microorganism in aqueous medium to grow, the method includes to institute
It states and adds phenoxetol and dipropylene glycol phenyl ether in aqueous medium, wherein the weight of phenoxetol and dipropylene glycol phenyl ether
Amount is than being 1: 0.01 to 1: 27.
Specific embodiment
" phenoxetol " is 2- phenoxy group -1- ethyl alcohol (CAS 122-99-6).Dipropylene glycol phenyl ether is No. CAS
The compound of 51730-94-0.Unless the context clearly, otherwise following term as used herein is determined with specified
Justice.Term " microbicide " refers to the compound for being able to suppress microorganism growth or control microorganism growth；Microbicide
Including bactericide, fungicide and algicide.Term " microorganism " include such as fungi (such as yeast and mould), bacterium and
Algae.This specification uses following abbreviation: the parts per million (w/w) of ppm=by weight in the whole text, and mL=milliliters.It removes
Non- other explanation, otherwise temperature is degree Celsius (DEG C), and the percentage referred to is weight percent (weight %), and amount and ratio
It is by active ingredient.
In the present invention, Synergistic antimicrobial compositions are formed by combination phenoxetol and dipropylene glycol phenyl ether.
Synergistic effect between phenoxetol and dipropylene glycol phenyl ether is confirmed in the range of 1: 0.01 and 1: 27.
Preferably, every kind of synergistic microbicidal compositions are substantially free of in addition to dipropylene glycol phenyl ether and phenoxetol
Microbicide, that is, it, which has, removes dipropylene glycol phenyl ether and benzene oxygen lower than 1 weight % by active constituent total weight
Microbicide except base ethyl alcohol, preferably shorter than 0.5 weight %, preferably shorter than 0.2 weight %, preferably shorter than 0.1 weight %.
Preferably, when aqueous media adds dipropylene glycol phenyl ether and phenoxetol, it is micro- that the medium is substantially free of its homicide
Biological agent, that is, it, which has, removes dipropylene glycol phenyl ether and phenoxetol lower than 1 weight % by active constituent total weight
Except microbicide, preferably shorter than 0.5 weight %, preferably shorter than 0.2 weight %, preferably shorter than 0.1 weight %.
Composition of the invention can contain other active components, such as defoaming agent and emulsifier.By to experience microorganism
The composition for killing antimicrobial effective amount is introduced in the aqueous medium of attack, Synergistic microbicidal compositions of the invention can be used for inhibiting micro-
Biological or more high form aquatile (such as protozoan, invertebrate, ectoproctous polyzoa, double flagellates, crustacean,
Mollusk etc.) growth.Suitable aqueous medium is present in for example: industrial treatment water；Electropaining film depositing system；Cooling tower；
Air washer；Gas washer；Ore pulp；Wastewater treatment；Ornamental fountain；Reverse osmosis filtering；Ultrafiltration；Ballast water；Evaporative condenser；Heat
Exchanger；Paper pulp and paper treatment fluid and additive；Starch；Plastics；Lotion；Dispersion liquid；Paint；Latex；Coating, such as clearly
Paint；Product for building, such as adhesive, gap filler and sealant；Sticker for building, such as ceramic sticker, carpet backing
Sticker and lamination sticker；Industrial or consumer's sticker；Photographic chemicals；Printing fluid；Family product, example
Such as washroom and kitchen cleaning agent；Cosmetics；Bath accessory；Shampoo；Soap；Personal care product, for example, wet tissue, lotion,
Suncream, hair conditioner, creams and other non-washing type applications；Detergent；Industrial cleaners；Floor polish composition；Rinsing clothes water；Gold
Belong to process fluid；Conveyor lubricant；Hydraulic fluid；Leather and leather products；Fabric；Textile；Timber and Wood products,
Such as glued board, sawdust-board, flakeboard, laminated beam, oriented wood chipboard, hardboard and particle board；PETROLEUM PROCESSING fluid；Combustion
Material；Oil field fluid, such as water for injection, fracturing fluid and drilling mud；Agricultural product auxiliary anticorrosion；Surfactant anti-corrosion；Doctor
Treat device；Diagnostic reagent anti-corrosion；Food Preservation, such as plastics or papery food packaging；Food, beverage and industrial treatment Pasteur disappear
Malicious device；Water closet；Recreational water；Pond；And wabering place.
The Specific amounts for inhibiting in the application or controlling Synergistic microbicidal compositions of the invention necessary to microorganism growth will
Change.In general, if the present composition amount provide 1, the composition of 000 to 30,000ppm (parts per million) activity at
Point, then it is enough to control microorganism growth.Preferably active constituent (i.e. the dipropylene glycol phenyl ether and phenoxy group second of composition
Alcohol) at least 2,000ppm, preferably at least 3,000ppm, the preferably at least amount of 4,000ppm is present in medium to be processed.
Preferably, the active constituent of composition with following amount be present in the medium: be no more than 16,000ppm, preferably more than 14,
000ppm, preferably more than 12,000ppm, preferably more than 10,000ppm, preferably more than 8,000ppm, preferably more than
7,000ppm.In the method for the invention, by concurrently or separately adding non-ionic surface with the amount that will generate above-mentioned concentration
Activating agent and phenoxetol carry out treatment compositions to suppress growth of microorganism.
Example
Phenoxetol and dipropylene glycol are evaluated by measuring combined index of cooperation (synergy index, S.I.)
The synergistic effect of phenyl ether.Based on the minimum inhibitory concentration individually with two kinds of Antimicrobe compounds (A and B) when combination
(MIC) index of cooperation is calculated.MIC tests the method according to described in U.S.9,034,905 and carries out.Test organism is that leather is blue
Family name's negative bacteria (Pseudomonas aeruginosa (Pseudomonas aeruginosa) ATCC#15442), gram-positive bacterium are (golden yellow
Staphylococcus (Staphylococcus aureus) ATCC#6538) and yeast (Candida albicans (Candida albicans)
) and mould (Brazil's aspergillus (Aspergillus brasiliensis) ATCC#16404) ATCC#10231.When the contact of bacterium
Between be 24 and 48 hours, time of contact of yeast is 48 and 72 hours, and the time of contact of mould is 3 and 7 days.Test is 96
It is carried out in the microtiter plate of hole.In more details shown in table 1-4 of test.
The product that table 1. is tested
The inoculum that table 2 uses
The medium that table 3. uses
For confirming that the test result of the synergistic effect of MIC combination is shown in Table 4.When each table is shown for incubating
Between the combination of two component results of microorganism tested；Pass through individual compounds A (CA), independent component B (CB) and mixture
(Ca) and the terminal as unit of ppm of the MIC of (Cb) measurement is active；SI calculated value；And the association for the every kind of combination tested
With the range of ratio.SI is calculated as follows:
Ca/CA+Cb/CB=index of cooperation (" SI ")
Wherein:
The concentration (MIC of compound A) as unit of ppm of terminal is generated when CA=compound A independent role.
Ca=compound A in the mixture when generate terminal the concentration as unit of ppm.
The concentration (MIC of compound B) as unit of ppm of terminal is generated when CB=compound B independent role.
Cb=compound B in the mixture when generate terminal the concentration as unit of ppm.
When the sum of Ca/CA and Cb/CB are greater than 1, antagonism is indicated.When with being equal to 1, addition is indicated, and
When with less than 1, it was demonstrated that synergistic effect.
The collaboration ratio (synergistic ratios) or ratio using level for reducing any component are only shown in table 4
Example (ratios).
Table 4
Ca: the component of the NeolonePH100 (phenoxetol) as unit of ppmAI
Cb: the component of the Dowanol DiPPh (dipropylene glycol phenyl ether) as unit of ppmAI
Ratio: Ca:Cb
Claims (4)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402769P | 2016-09-30 | 2016-09-30 | |
| US62/402769 | 2016-09-30 | ||
| PCT/US2017/053203 WO2018063971A1 (en) | 2016-09-30 | 2017-09-25 | Microbicidal composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109688814A true CN109688814A (en) | 2019-04-26 |
Family
ID=60037721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780055758.7A Pending CN109688814A (en) | 2016-09-30 | 2017-09-25 | Microbicide composition |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11849726B2 (en) |
| EP (1) | EP3518674B1 (en) |
| JP (2) | JP2019532923A (en) |
| CN (1) | CN109688814A (en) |
| ES (1) | ES2965944T3 (en) |
| MX (1) | MX2019003400A (en) |
| PL (1) | PL3518674T3 (en) |
| WO (1) | WO2018063971A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019136398A (en) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | Game machine |
| JP2019136400A (en) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | Game machine |
| JP2019136399A (en) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | Game machine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102433036A (en) * | 2010-06-25 | 2012-05-02 | 陶氏环球技术有限公司 | Coalescent for aqueous compositions |
| CN105592697A (en) * | 2013-10-03 | 2016-05-18 | 陶氏环球技术有限责任公司 | Microbicidal composition comprising phenoxyethanol |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4295932A (en) | 1980-07-14 | 1981-10-20 | Naloc Chemical Company | Synergistic blend of biocides |
| DE3904099C1 (en) * | 1989-02-11 | 1990-07-12 | Schuelke & Mayr Gmbh, 2000 Norderstedt, De | |
| DE3943562C2 (en) * | 1989-08-24 | 1994-07-14 | Schuelke & Mayr Gmbh | Disinfectants and preservatives |
| JP2899946B2 (en) * | 1994-11-01 | 1999-06-02 | 花王株式会社 | Aqueous detergent composition |
| DE10224979B4 (en) | 2002-06-05 | 2004-07-15 | Schülke & Mayr GmbH | Use of synergistic preparations based on mixtures of glycerol ether with aromatic alcohol to combat mycobacteria |
| US9034905B2 (en) * | 2003-02-05 | 2015-05-19 | Rohm And Haas Company | Synergistic microbicidal combinations |
| KR100554450B1 (en) | 2003-05-07 | 2006-03-03 | 주식회사 우보테크 | Car Armrests |
| JP5481714B2 (en) | 2007-09-20 | 2014-04-23 | ライオン株式会社 | Liquid detergent composition |
| CN102361554A (en) | 2009-03-26 | 2012-02-22 | 陶氏环球技术公司 | Biocidal compositions and methods of use of 2,6-dimethyl-m-dioxan-4-ol acetate |
| US9415330B2 (en) | 2010-12-02 | 2016-08-16 | Dow Brasil Sudeste Industrial Ltda. | Blends of polypropylene polyglycol and phenolic glycol ethers and method of foam control using such blend |
| DE102011085798A1 (en) * | 2011-11-04 | 2013-05-08 | Symrise Ag | Synergistically active ternary antimicrobial mixtures |
| JP2016507612A (en) | 2012-12-20 | 2016-03-10 | ブルー キューブ アイピー エルエルシー | Low emission epoxy curing agent |
| JP6142991B2 (en) | 2013-03-29 | 2017-06-07 | セイコーエプソン株式会社 | Inkjet recording device |
-
2017
- 2017-09-25 CN CN201780055758.7A patent/CN109688814A/en active Pending
- 2017-09-25 US US16/324,168 patent/US11849726B2/en active Active
- 2017-09-25 EP EP17780957.1A patent/EP3518674B1/en active Active
- 2017-09-25 ES ES17780957T patent/ES2965944T3/en active Active
- 2017-09-25 MX MX2019003400A patent/MX2019003400A/en unknown
- 2017-09-25 JP JP2019513853A patent/JP2019532923A/en active Pending
- 2017-09-25 WO PCT/US2017/053203 patent/WO2018063971A1/en not_active Ceased
- 2017-09-25 PL PL17780957.1T patent/PL3518674T3/en unknown
-
2022
- 2022-07-22 JP JP2022117035A patent/JP7377926B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102433036A (en) * | 2010-06-25 | 2012-05-02 | 陶氏环球技术有限公司 | Coalescent for aqueous compositions |
| CN105592697A (en) * | 2013-10-03 | 2016-05-18 | 陶氏环球技术有限责任公司 | Microbicidal composition comprising phenoxyethanol |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3518674B1 (en) | 2023-09-20 |
| BR112019004784A2 (en) | 2019-06-04 |
| EP3518674A1 (en) | 2019-08-07 |
| US20200205405A1 (en) | 2020-07-02 |
| PL3518674T3 (en) | 2024-03-11 |
| JP2019532923A (en) | 2019-11-14 |
| US11849726B2 (en) | 2023-12-26 |
| ES2965944T3 (en) | 2024-04-17 |
| WO2018063971A1 (en) | 2018-04-05 |
| JP7377926B2 (en) | 2023-11-10 |
| JP2022141874A (en) | 2022-09-29 |
| MX2019003400A (en) | 2019-07-18 |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210317 Address after: Delaware, USA Applicant after: DDP special electronic materials USA No.8 Co.,Ltd. Address before: Pennsylvania, USA Applicant before: Rohm and Haas Co. Effective date of registration: 20210317 Address after: New York State, USA Applicant after: Nutrition and biotechnology USA second Ltd. Address before: Delaware, USA Applicant before: DDP special electronic materials USA No.8 Co.,Ltd. |
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