CN109568651A - A kind of long-lasting liquid dressing - Google Patents
A kind of long-lasting liquid dressing Download PDFInfo
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- CN109568651A CN109568651A CN201811583910.1A CN201811583910A CN109568651A CN 109568651 A CN109568651 A CN 109568651A CN 201811583910 A CN201811583910 A CN 201811583910A CN 109568651 A CN109568651 A CN 109568651A
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- 239000007788 liquid Substances 0.000 title claims abstract description 35
- 230000005923 long-lasting effect Effects 0.000 title claims abstract description 21
- 239000001913 cellulose Substances 0.000 claims abstract description 51
- 229920002678 cellulose Polymers 0.000 claims abstract description 51
- 239000003094 microcapsule Substances 0.000 claims abstract description 43
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 39
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 39
- 241000894006 Bacteria Species 0.000 claims abstract description 31
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000011259 mixed solution Substances 0.000 claims abstract description 26
- 229920001661 Chitosan Polymers 0.000 claims abstract description 23
- 239000000017 hydrogel Substances 0.000 claims abstract description 22
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 21
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 21
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 21
- 239000011734 sodium Substances 0.000 claims abstract description 21
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 15
- 150000001718 carbodiimides Chemical class 0.000 claims abstract description 13
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 13
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 6
- 239000004615 ingredient Substances 0.000 claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 72
- 239000000243 solution Substances 0.000 claims description 56
- 238000003756 stirring Methods 0.000 claims description 27
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 24
- 229940069328 povidone Drugs 0.000 claims description 24
- 238000002156 mixing Methods 0.000 claims description 23
- 239000000839 emulsion Substances 0.000 claims description 22
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 20
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 20
- 229920000053 polysorbate 80 Polymers 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 15
- 229920002101 Chitin Polymers 0.000 claims description 14
- 230000006196 deacetylation Effects 0.000 claims description 12
- 238000003381 deacetylation reaction Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 12
- 239000003921 oil Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- 238000005119 centrifugation Methods 0.000 claims description 9
- 238000012545 processing Methods 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000011017 operating method Methods 0.000 claims description 2
- 239000012266 salt solution Substances 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- -1 silicon quaternary ammonium salt Chemical class 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims 3
- 239000000835 fiber Substances 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 16
- 229940079593 drug Drugs 0.000 abstract description 15
- 239000004964 aerogel Substances 0.000 abstract description 6
- 230000003578 releasing effect Effects 0.000 abstract description 4
- 230000000857 drug effect Effects 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 2
- 238000007599 discharging Methods 0.000 abstract description 2
- 230000002459 sustained effect Effects 0.000 abstract description 2
- 230000008961 swelling Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012567 medical material Substances 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 30
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
- 230000005855 radiation Effects 0.000 description 11
- 125000001453 quaternary ammonium group Chemical group 0.000 description 10
- 238000009938 salting Methods 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000007710 freezing Methods 0.000 description 8
- 230000008014 freezing Effects 0.000 description 8
- 230000002045 lasting effect Effects 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- 239000000499 gel Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 230000035876 healing Effects 0.000 description 4
- 238000001237 Raman spectrum Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/622—Microcapsules
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to medical material production technical fields, specifically disclose a kind of long-lasting liquid dressing, the long-acting aerogel dressing of the present invention is the hydrogel microcapsule dressing being prepared by nano silver, hydroxy cellulose sodium, bacteria cellulose, modified chitosan, and the gel-type vehicle of hydrogel is polyvinylpyrrolidone；Microcapsules by with hydroxy cellulose sodium, bacteria cellulose, modified chitosan and nano silver ingredient mixed solution, atoleine and emulsifier, and be prepared by crosslinking agent of carbodiimides.By the way that nano silver is wrapped in microcapsules, then gel-type vehicle is added in microcapsules again and forms aerogel dressing, microcapsules gradually occur swelling and release drug ingedient, realize the controllability discharged to drug ingedient, with slow releasing function, sustained drug long-acting can be made in wound, avoiding traditional dressing from directly discharging drug induced drug ingedient completely cannot continue to play drug effect, need to constantly change the defect of dressing.
Description
Technical field
The present invention relates to a kind of medical dressing patch, specifically a kind of long-lasting liquid dressing.
Background technique
Dressing essential material when being wrapping, processing wound or the surface of a wound.Medical dressing, which refers to, to be covered on the surface of a wound,
Play the role of temporarily substituting damaged skin protective tissue in the continuous rehabilitation course of the surface of a wound, as a kind of barrier, avoids surface of a wound quilt
External environmental pollution, while a kind of medical supplies of excellent healing rehabilitation environment being provided.In order to promote the healing of the surface of a wound, usually
Need to be added some functional ingredients, such as antimicrobial component, promoting healing ingredient, hemostatic compositions etc. in dressings.However it passes
Functional components in the dressing of system are usually to be fabricated to not with the reset condition of the ingredient directly as one of the raw material of dressing
With the dressing of form, such as in aerogel dressing, antibacterial agent, hemostatic compositions is added, gel-type vehicle is added directly as raw material
In, aerogel dressing is made.Although the dressing of this traditional approach preparation can also play antibacterial, the rush that functional components have
Heal effect, but its drug ingedient is disposably directly to discharge completely, and the medicine effect duration is short, hair that cannot be long-acting
Wave to the surface of a wound sterilization and promoting healing effect, need ceaselessly more change dressings, cause using inconvenience.
Medicine controlled releasing is slowly to discharge drug outward by controlled release agent, and drug effect is made to keep constant, drug control for a long time
The function of making release can be reached by film through control system, body diffusion system.The dressing controlled release ratio of existing drug containing auxiliary material
It is more difficult, it can not meet daily medical demand, in known gel processing procedure, since the reaction mixing to form gel is molten
Solution state can be presented in liquid before carrying out polymerization reaction, therefore need to first contain and carry out polymerization reaction in a reservoir to form gel
Block, then gel mass is cut into the gel dressing with suitable thickness and size, processing procedure is cumbersome.
Summary of the invention
The main purpose of the present invention is to provide a kind of long-lasting liquid dressing, can slow nano silver, have long-acting anti-
Bacterium performance.The hydrogel being specially prepared by nano silver, hydroxy cellulose sodium, bacteria cellulose, modified chitosan is micro-
Capsule dressing.The gel-type vehicle of hydrogel is polyvinylpyrrolidone；Microcapsules by with hydroxy cellulose sodium, bacteria cellulose,
The mixed solution of modified chitosan and nano silver ingredient, atoleine and emulsifier, and using carbodiimides as crosslinking agent
It is prepared.
The preparation method of above-mentioned hydrogel microcapsule, including following operating procedure:
(1) it will be added in aqueous slkali and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state, acid solution is recycled to carry out
It neutralizes, is then washed with deionized to neutrality；
(2) bacteria cellulose and nano silver, hydroxy cellulose sodium, modified chitosan that step (1) is prepared are added
Enter in organosilicone quaternary ammonium salting liquid, after mixing, obtains mixed solution；
(3) atoleine is taken, emulsifier is added, is uniformly mixed；
(4) mixture prepared by step (3) is added dropwise in mixed solution prepared by step (2), during dropwise addition
Be stirred continuously to form emulsion, after being added dropwise, crosslinking agent carbodiimides added in emulsion, after persistently stir, be centrifuged
Upper layer oil reservoir is discarded, retains lower layer's particle, to get microcapsules after washing, freeze-drying；
(5) aqueous povidone solution is prepared, the microcapsules of glycerol and step (5) preparation are added, after mixing,
Radiation treatment forms hydrogel.
Nano silver, hydroxy cellulose sodium, bacteria cellulose and modified chitosan preferred mass ratio: (0.01-0.1):
(10-20): (20-50): (10-20), further preferably are as follows: (0.05-0.1): (15-20): (30-50): (10-15), into one
Step is preferably 0.1:15:40:10.
The mass concentration of organosilicon quaternary ammonium salt is preferably 2-5% in step (2).
Emulsifier is preferably Tween 80 and span80 according to 1:(2-5 in step (3)) mixture of ratio.
Speed of agitator is preferably 1200-1500r/min in step (4).
The mass concentration of aqueous povidone solution is preferably 5-10% in step (5).
Glycerol in step (5), the microcapsules of step (5) preparation, aqueous povidone solution mass ratio be preferably
1:(10-20):(20-30)。
Modified chitosan preferably uses the deacetylated product of chitin, or the derivative using modified chitin or chitin
Object, further preferred chitin deacetylation are 60-80%, and more preferable chitin deacetylation is 80%.
Then by the way that nano silver to be wrapped in microcapsules gel is added again in microcapsules by the long-acting aerogel dressing of the present invention
Matrix forms aerogel dressing, and in use, dressing is coated in the surface of a wound, in the effect of wound fluid and body temperature for the dressing
Under, microcapsules gradually occur swelling and release drug ingedient, realize the controllability discharged to drug ingedient, there is slow releasing function,
Sustained drug long-acting can be made in wound, avoiding traditional dressing from directly discharging drug induced drug ingedient completely cannot continue
Drug effect is played, the defect of dressing is needed to constantly change.
Specific embodiment
Principles and features of the present invention are described in following implementation, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the invention.
Embodiment 1
The preparation method of the present embodiment long-lasting liquid dressing, comprising the following steps:
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) 40g bacteria cellulose and 50mg nano silver, 10g hydroxy cellulose sodium, 20g that step (1) is prepared are changed
Property chitosan (chitin deacetylation be 80%) be added in organosilicone quaternary ammonium salting liquid, the mass concentration of organosilicon quaternary ammonium salt
It is 5%, after mixing, obtains mixed solution；
(3) atoleine is taken, according to Tween 80: the mass ratio of span80=1:3 is added in atoleine, so that Tween 80
Mass percentage with span80 is 8%, is uniformly mixed；
(4) mixture 150g prepared by step (3) is added dropwise in mixed solution prepared by step (2), was added dropwise
It is stirred continuously to form emulsion in journey, stirring rate 1200r/min, after being added dropwise, crosslinking agent 5g carbodiimides is added to
Lasting to stir in emulsion, stirring rate 1500r/min, centrifugation discards upper layer oil reservoir, retains lower layer's particle, and washing, freezing are dry
To get microcapsules after dry；
(5) aqueous povidone solution that mass concentration is 5% is prepared, according to glycerol and polyvinylpyrrolidone water
Glycerol is added in the mass ratio that the mass ratio of solution is 1:20, according to the volume ratio of microcapsules and aqueous povidone solution
Microcapsules are added for 1:20, after mixing, radiation treatment forms hydrogel.
Embodiment 2
The preparation method of the present embodiment long-lasting liquid dressing, comprising the following steps:
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) 20g bacteria cellulose and 100mg nano silver, the 20g hydroxy cellulose sodium, 15g step (1) being prepared
Modified chitosan (chitin deacetylation is 70%) is added in organosilicone quaternary ammonium salting liquid, and the quality of organosilicon quaternary ammonium salt is dense
Degree is 7%, after mixing, obtains mixed solution；
(3) atoleine is taken, according to Tween 80: the mass ratio of span80=1:3 is added in atoleine, so that Tween 80
Mass percentage with span80 is 10%, is uniformly mixed；
(4) mixture 120g prepared by step (3) is added dropwise in mixed solution prepared by step (2), was added dropwise
It is stirred continuously to form emulsion in journey, stirring rate 1200r/min, after being added dropwise, crosslinking agent 8g carbodiimides is added to
Lasting to stir in emulsion, stirring rate 1500r/min, centrifugation discards upper layer oil reservoir, retains lower layer's particle, and washing, freezing are dry
To get microcapsules after dry；
(5) aqueous povidone solution that mass concentration is 10% is prepared, according to glycerol and polyvinylpyrrolidone
Glycerol is added in the mass ratio that the mass ratio of aqueous solution is 1:25, according to the volume of microcapsules and aqueous povidone solution
Than microcapsules are added for 1:20, after mixing, radiation treatment forms hydrogel.
Embodiment 3
The preparation method of the present embodiment long-lasting liquid dressing, comprising the following steps:
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) 50g bacteria cellulose and 30mg nano silver, 15g hydroxy cellulose sodium, 10g that step (1) is prepared are changed
Property chitosan (chitin deacetylation be 60%) be added in organosilicone quaternary ammonium salting liquid, the mass concentration of organosilicon quaternary ammonium salt
It is 8%, after mixing, obtains mixed solution；
(3) atoleine is taken, according to Tween 80: the mass ratio of span80=1:5 is added in atoleine, so that Tween 80
Mass percentage with span80 is 10%, is uniformly mixed；
(4) mixture 180g prepared by step (3) is added dropwise in mixed solution prepared by step (2), was added dropwise
It is stirred continuously to form emulsion in journey, stirring rate 1200r/min, after being added dropwise, crosslinking agent 5g carbodiimides is added to
Lasting to stir in emulsion, stirring rate 1500r/min, centrifugation discards upper layer oil reservoir, retains lower layer's particle, and washing, freezing are dry
To get microcapsules after dry；
(5) aqueous povidone solution that mass concentration is 8% is prepared, according to glycerol and polyvinylpyrrolidone water
Glycerol is added in the mass ratio that the mass ratio of solution is 1:10, according to the volume ratio of microcapsules and aqueous povidone solution
Microcapsules are added for 1:15, after mixing, radiation treatment forms hydrogel.
Embodiment 4
The preparation method of the present embodiment long-lasting liquid dressing, comprising the following steps:
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) 30g bacteria cellulose and 80mg nano silver, 20g hydroxy cellulose sodium, 20g that step (1) is prepared are changed
Property chitosan (chitin deacetylation be 80%) be added in organosilicone quaternary ammonium salting liquid, the mass concentration of organosilicon quaternary ammonium salt
It is 10%, after mixing, obtains mixed solution；
(3) atoleine is taken, according to Tween 80: the mass ratio of span80=1:4 is added in atoleine, so that Tween 80
Mass percentage with span80 is 10%, is uniformly mixed；
(4) mixture 160g prepared by step (3) is added dropwise in mixed solution prepared by step (2), was added dropwise
It is stirred continuously to form emulsion in journey, stirring rate 1200r/min, after being added dropwise, crosslinking agent 5g carbodiimides is added to
Lasting to stir in emulsion, stirring rate 1500r/min, centrifugation discards upper layer oil reservoir, retains lower layer's particle, and washing, freezing are dry
To get microcapsules after dry；
(5) aqueous povidone solution that mass concentration is 10% is prepared, according to glycerol and polyvinylpyrrolidone
Glycerol is added in the mass ratio that the mass ratio of aqueous solution is 1:10, according to the volume of microcapsules and aqueous povidone solution
Than microcapsules are added for 1:20, after mixing, radiation treatment forms hydrogel.
Embodiment 5
The preparation method of the present embodiment long-lasting liquid dressing, comprising the following steps:
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) 50g bacteria cellulose and 60mg nano silver, 10g hydroxy cellulose sodium, 15g that step (1) is prepared are changed
Property chitosan (chitin deacetylation be 80%) be added in organosilicone quaternary ammonium salting liquid, the mass concentration of organosilicon quaternary ammonium salt
It is 10%, after mixing, obtains mixed solution；
(3) atoleine is taken, according to Tween 80: the mass ratio of span80=1:3 is added in atoleine, so that Tween 80
Mass percentage with span80 is 10%, is uniformly mixed；
(4) mixture 170g prepared by step (3) is added dropwise in mixed solution prepared by step (2), was added dropwise
It is stirred continuously to form emulsion in journey, stirring rate 1200r/min, after being added dropwise, crosslinking agent 6g carbodiimides is added to
Lasting to stir in emulsion, stirring rate 1500r/min, centrifugation discards upper layer oil reservoir, retains lower layer's particle, and washing, freezing are dry
To get microcapsules after dry；
(5) aqueous povidone solution that mass concentration is 9% is prepared, according to glycerol and polyvinylpyrrolidone water
Glycerol is added in the mass ratio that the mass ratio of solution is 1:10, according to the volume ratio of microcapsules and aqueous povidone solution
Microcapsules are added for 1:20, after mixing, radiation treatment forms hydrogel.
Comparative example 1
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) the modified chitosan (crust of 50mg nano silver, 10g hydroxy cellulose sodium, 20g step (1) being prepared
Plain deacetylation is 80%) to be added in organosilicone quaternary ammonium salting liquid, and the mass concentration of organosilicon quaternary ammonium salt is 5%, is uniformly mixed
Afterwards, mixed solution is obtained；
(3) atoleine is taken, according to Tween 80: the mass ratio of span80=1:3 is added in atoleine, so that Tween 80
Mass percentage with span80 is 8%, is uniformly mixed；
(4) mixture 150g prepared by step (3) is added dropwise in mixed solution prepared by step (2), was added dropwise
It is stirred continuously to form emulsion in journey, stirring rate 1200r/min, after being added dropwise, crosslinking agent 5g carbodiimides is added to
Lasting to stir in emulsion, stirring rate 1500r/min, centrifugation discards upper layer oil reservoir, retains lower layer's particle, and washing, freezing are dry
To get microcapsules after dry；
(5) aqueous povidone solution that mass concentration is 5% is prepared, according to glycerol and polyvinylpyrrolidone water
Glycerol is added in the mass ratio that the mass ratio of solution is 1:20, according to the volume ratio of microcapsules and aqueous povidone solution
Microcapsules are added for 1:20, after mixing, radiation treatment forms hydrogel.
Comparative example 2
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) the modified chitosan (crust of 40g bacteria cellulose and 50mg nano silver, 20g step (1) being prepared
Plain deacetylation is 80%) to be added in organosilicone quaternary ammonium salting liquid, and the mass concentration of organosilicon quaternary ammonium salt is 5%, is uniformly mixed
Afterwards, mixed solution is obtained；
(3) atoleine is taken, according to Tween 80: the mass ratio of span80=1:3 is added in atoleine, so that Tween 80
Mass percentage with span80 is 8%, is uniformly mixed；
(4) mixture 150g prepared by step (3) is added dropwise in mixed solution prepared by step (2), was added dropwise
It is stirred continuously to form emulsion in journey, stirring rate 1200r/min, after being added dropwise, crosslinking agent 5g carbodiimides is added to
Lasting to stir in emulsion, stirring rate 1500r/min, centrifugation discards upper layer oil reservoir, retains lower layer's particle, and washing, freezing are dry
To get microcapsules after dry；
(5) aqueous povidone solution that mass concentration is 5% is prepared, according to glycerol and polyvinylpyrrolidone water
Glycerol is added in the mass ratio that the mass ratio of solution is 1:20, according to the volume ratio of microcapsules and aqueous povidone solution
Microcapsules are added for 1:20, after mixing, radiation treatment forms hydrogel.
Comparative example 3
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) 40g bacteria cellulose and 50mg nano silver that step (1) is prepared, the addition of 10g hydroxy cellulose sodium are had
In machine silicon quaternary ammonium salt solution, the mass concentration of organosilicon quaternary ammonium salt is 5%, after mixing, obtains mixed solution；
(3) atoleine is taken, according to Tween 80: the mass ratio of span80=1:3 is added in atoleine, so that Tween 80
Mass percentage with span80 is 8%, is uniformly mixed；
(4) mixture 150g prepared by step (3) is added dropwise in mixed solution prepared by step (2), was added dropwise
It is stirred continuously to form emulsion in journey, stirring rate 1200r/min, after being added dropwise, crosslinking agent 5g carbodiimides is added to
Lasting to stir in emulsion, stirring rate 1500r/min, centrifugation discards upper layer oil reservoir, retains lower layer's particle, and washing, freezing are dry
To get microcapsules after dry；
(5) aqueous povidone solution that mass concentration is 5% is prepared, according to glycerol and polyvinylpyrrolidone water
Glycerol is added in the mass ratio that the mass ratio of solution is 1:20, according to the volume ratio of microcapsules and aqueous povidone solution
Microcapsules are added for 1:20, after mixing, radiation treatment forms hydrogel.
Comparative example 4
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) 40g bacteria cellulose and 50mg nano silver, 10g hydroxy cellulose sodium, 20g that step (1) is prepared are changed
Property chitosan (chitin deacetylation be 80%) be added in organosilicone quaternary ammonium salting liquid, the mass concentration of organosilicon quaternary ammonium salt
It is 5%, after mixing, obtains mixed solution；
(3) aqueous povidone solution that mass concentration is 5% is prepared, according to glycerol and polyvinylpyrrolidone water
Glycerol is added in the mass ratio that the mass ratio of solution is 1:20, according to the mixed solution and polyvinylpyrrolidone water of step (2)
The volume ratio of solution is the mixed solution that step (2) are added in 1:20, and after mixing, radiation treatment forms hydrogel.
Comparative example 5
(1) it will be added in the NaOH solution of 30% mass concentration and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state,
It recycles the hydrochloric acid solution of 20% mass concentration to be neutralized, is then washed with deionized to neutrality；
(2) 40g bacteria cellulose and 50mg nano silver, 10g hydroxy cellulose sodium, 20g that step (1) is prepared are changed
Property chitosan (chitin deacetylation be 80%), 120g atoleine, 10g Tween 80 and span80 (Tween 80: span80
=1:3), it is added in organosilicone quaternary ammonium salting liquid, the mass concentration of organosilicon quaternary ammonium salt is 5%, after mixing, must mix cream
Liquid；
(3) aqueous povidone solution that mass concentration is 5% is prepared, according to glycerol and polyvinylpyrrolidone water
Glycerol is added in the mass ratio that the mass ratio of solution is 1:20, according to the volume of mixed emulsion and aqueous povidone solution
Than being added in mixed emulsion for 1:20, after mixing, radiation treatment forms hydrogel.
The test of 6 rate of release of embodiment
Test method: its pH=is adjusted by citric acid is separately added into the hydrogel of embodiment 1-5 and comparative example 1-5 preparation
5.5, hydrogel is heated to 35-40 DEG C of progress Acceleration study, every the total of the nano silver that 0.5 hour releases in detection hydrogel
Mass content.Nano silver is measured using Raman spectrum, and specific test condition is as follows when test:
Excitation light source wavelength: 785nm
Excitation light source intensity: about 3mW
Object lens magnification: 10
Raman spectrum tests section: 300cm-1-900cm-1
Each Raman spectrum test interval: 120s.
As a result as follows:
1 rate of release test result of table
The results show that the embodiment of the present invention 1-5 has preferable control releasing effect, can be made with the extended release time
It must discharge more uniform, reach preferable fungistatic effect, the hydrogel rate of release of comparative example 1-5 is too fast, needs to frequently replace
Dressing.
Claims (11)
1. a kind of long-lasting liquid dressing, is characterized in that, the dressing is by nano silver, hydroxy cellulose sodium, bacteria cellulose, changes
Property the hydrogel microcapsule dressing that is prepared of chitosan, the gel-type vehicle of hydrogel is polyvinylpyrrolidone；Microcapsules
By with hydroxy cellulose sodium, bacteria cellulose, the mixed solution for being modified chitosan and nano silver ingredient, atoleine and cream
Agent, and be prepared by crosslinking agent of carbodiimides.
2. long-lasting liquid dressing according to claim 1, which is characterized in that the preparation method of the liquid dressing include with
Lower operating procedure:
(1) it will be added in aqueous slkali and heat after the cotton-shaped bacteria cellulose rinsing of hygrometric state, acid solution is recycled to be neutralized,
Then it is washed with deionized to neutrality；
(2) bacteria cellulose and nano silver, hydroxy cellulose sodium, modified chitosan addition that step (1) is prepared are had
In machine silicon quaternary ammonium salt solution, after mixing, mixed solution is obtained；
(3) atoleine is taken, emulsifier is added, is uniformly mixed；
(4) mixture prepared by step (3) is added dropwise in mixed solution prepared by step (2), it is continuous during dropwise addition
Stirring form emulsion, after being added dropwise, crosslinking agent carbodiimides is added in emulsion, after persistently stir, centrifugation discards
Upper layer oil reservoir retains lower layer's particle, to get microcapsules after washing, freeze-drying；
(5) aqueous povidone solution is prepared, the microcapsules of glycerol and step (5) preparation, after mixing, irradiation are added
Processing forms dressing.
3. long-lasting liquid dressing according to claim 2, which is characterized in that nano silver, hydroxy cellulose sodium, bacterial fibers
Element and modified chitosan mass ratio are as follows: 0.01-0.1): (10-20): (20-50): (10-20).
4. long-lasting liquid dressing according to claim 2, which is characterized in that nano silver, hydroxy cellulose sodium, bacterial fibers
Element and modified chitosan mass ratio are as follows: (0.05-0.1): (15-20): (30-50): (10-15)
5. long-lasting liquid dressing according to claim 2, which is characterized in that nano silver, hydroxy cellulose sodium, bacterial fibers
Element and modified chitosan mass ratio are 0.1:15:40:10.
6. long-lasting liquid dressing according to claim 2, which is characterized in that the quality of organosilicon quaternary ammonium salt in step (2)
Concentration is 2-5%.
7. long-lasting liquid dressing according to claim 2, which is characterized in that in step (3) emulsifier be Tween 80 and
Span80 is according to 1:(2-5) mixture of ratio.
8. long-lasting liquid dressing according to claim 2, which is characterized in that speed of agitator is 1200- in step (4)
1500r/min。
9. long-lasting liquid dressing according to claim 2, which is characterized in that polyvinylpyrrolidone is water-soluble in step (5)
The mass concentration of liquid is 5-10%.
10. long-lasting liquid dressing according to claim 2, which is characterized in that in step (5) prepared by glycerol, step (5)
Microcapsules, aqueous povidone solution mass ratio be 1:(10-20): (20-30).
11. long-lasting liquid dressing according to claim 2, which is characterized in that modified chitosan takes off second using chitin
Acyl product, chitin deacetylation are 60-80%.
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