CN109567935A - A kind of laser therapeutic system of combination tumour cell detection - Google Patents
A kind of laser therapeutic system of combination tumour cell detection Download PDFInfo
- Publication number
- CN109567935A CN109567935A CN201811500315.7A CN201811500315A CN109567935A CN 109567935 A CN109567935 A CN 109567935A CN 201811500315 A CN201811500315 A CN 201811500315A CN 109567935 A CN109567935 A CN 109567935A
- Authority
- CN
- China
- Prior art keywords
- laser
- tumour cell
- therapeutic system
- fluorescent
- laser therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004881 tumor cell Anatomy 0.000 title claims abstract description 32
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 22
- 238000001514 detection method Methods 0.000 title claims abstract description 14
- 239000000523 sample Substances 0.000 claims abstract description 22
- 238000002647 laser therapy Methods 0.000 claims abstract description 15
- 230000008685 targeting Effects 0.000 claims abstract description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 18
- 229920001184 polypeptide Polymers 0.000 claims description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
- 238000003384 imaging method Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 9
- 239000000835 fiber Substances 0.000 claims description 8
- 238000012632 fluorescent imaging Methods 0.000 claims description 8
- 230000008520 organization Effects 0.000 claims description 7
- 229910052761 rare earth metal Inorganic materials 0.000 claims description 7
- 229910052775 Thulium Inorganic materials 0.000 claims description 6
- 238000004020 luminiscence type Methods 0.000 claims description 6
- FRNOGLGSGLTDKL-UHFFFAOYSA-N thulium atom Chemical compound [Tm] FRNOGLGSGLTDKL-UHFFFAOYSA-N 0.000 claims description 6
- 238000000799 fluorescence microscopy Methods 0.000 claims description 5
- 239000002159 nanocrystal Substances 0.000 claims description 5
- 150000002910 rare earth metals Chemical group 0.000 claims description 5
- 238000012377 drug delivery Methods 0.000 claims description 4
- 230000000007 visual effect Effects 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 3
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000001900 immune effect Effects 0.000 abstract description 3
- 238000003780 insertion Methods 0.000 abstract description 3
- 230000037431 insertion Effects 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 3
- 238000001356 surgical procedure Methods 0.000 abstract description 3
- 239000013307 optical fiber Substances 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000001112 coagulating effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 208000012260 Accidental injury Diseases 0.000 description 1
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 description 1
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00589—Coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00601—Cutting
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Electromagnetism (AREA)
- Optics & Photonics (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Radiation-Therapy Devices (AREA)
- Endoscopes (AREA)
Abstract
The present invention provides a kind of laser therapeutic system of combination tumour cell detection, in laser therapy, the detection to tumour cell is realized using tumour cell targeting specific fluorescence probe, realize the accurate mark to tumour cell, auxiliary doctor distinguishes normal tissue and tumour cell during surgery, realize the accurate processing to tumour cell, and this system realizes that minimally invasive insertion type is directly administered using endoscope, realize the accurate administration to target site, greatly improve detection accuracy, and pharmaceutical use is effectively reduced, reduce bad and immunological rejection.The present invention can provide the precise information of therapentic part for user, help to improve treatment accuracy, reduce error, also greatly facilitate user, improve the operating characteristics of laser therapeutic apparantus.
Description
Technical field
The present invention relates to a kind of laser therapeutic systems, more particularly to a kind of laser therapy system of combination tumour cell detection
System.
Background technique
In recent years, with the continuous development of laser technology, laser is in disease treatment field using more and more extensive.Using
Laser action is in human body and treats disease, is primarily referred to as the fuel factor using laser to biological tissue, inhales in the tissue of exposure
Heat is generated after receiving luminous energy, increase the temperature of organization internal, tissue is solidified, burn, cut off or is vaporized.Laser therapy tool
Have the advantage that bleeding is few or not bleeding；Surgical field of view is clear, and surgical quality is high；Without Mechanical Contact in art, so as to avoid connecing
The sexy dye of touching；Pain is light in art, and after-operation response is small.But there is also some limitations for laser therapy, such as, it is difficult to it is accurate to control
Especially in surgical operation, the accidental injury that be easy to cause except diseased region；Therapeutic effect can not be determined after the treatment；It is special
It is not that effective inspection and means of tracking are more a lack of for subcutaneous tissue and bodily lumen.Existing laser therapeutic apparantus passes through
Endoscope obtains the image information for the treatment of object in human body, and the image information that user obtains according to endoscope is defeated to laser
Power is set out.And the high energy pulse laser that laser generates passes through optical fiber again and is transferred into human body, until therapentic part.
But the therapentic part image that is obtained by endoscope of user can only be general the information for knowing therapentic part, can not be comprehensive
Grasp therapentic part information, can only according to endoscopic images and by personal experience set laser output power, especially
For the tumor resection of some vital tissue organs, only with being visually difficult to distinguish tumour cell and normal tissue.In addition,
In surgical operation, surgical field of view has suffered from the interference of operation residue such as blood, water etc., seriously affects the judgement of doctor.
CN104789207A discloses a kind of rare earth ion doped nano fluorophor of hydrophily, and rare earth upconversion nano crystal is glimmering
Luminescent material utilizes two-photon absorption property of the rare earth ion Yb3+ at 980nm, in the laser that wavelength is 980nm as exciting light
Under source excitation, the relatively short fluorescence of wavelength can be launched.But for exciting the near infrared light of upconverting fluorescent material to people
The penetration capacity of body tissue is limited, and upconverting fluorescent material luminous efficiency is low, when upper conversion nano fluorescent particles are gathered in depth
When layer tissue or organ, external excitation light source cannot excite intracorporal nanoparticle and obtain fluorescence signal.
CN108815537A discloses a kind of tumour cell targeting specific fluorescence probe and the preparation method and application thereof,
The part that fluorescence probe contains polypeptide complex and fluorescent molecule is connected to form；The polypeptide complex by target polypeptide, wear
Film peptide, the peptide containing binding groups and nuclear location peptide are formed by connecting in any order；The polypeptide complex passes through the bonding
Group and the fluorescent molecule are covalently attached；The fluorescent molecule is aggregation-induced emission compound.The fluorescence probe has target
To being positioned at high express alphaⅤβ3And/or CD13The tumour cell of albumen, and taken polypeptide, fluorescent molecule orientation are transferred to cell
It is interior, have many advantages, such as fluorescence imaging in core, good biocompatibility, low toxicity, the target to pathogenic sites such as tumours may be implemented
To combination and fluorescence imaging, it can also be used to pharmaceutical carrier.
Summary of the invention
To solve the above problems, the present invention provides a kind of laser therapeutic system of combination tumour cell detection, controlled in laser
In treatment, the detection to tumour cell is realized using tumour cell targeting specific fluorescence probe, is realized to the accurate of tumour cell
Mark, auxiliary doctor distinguish normal tissue and tumour cell during surgery, realize the accurate processing to tumour cell, and this system
It realizes that minimally invasive insertion type is directly administered using endoscope, realizes the accurate administration to target site, greatly improve detection
Accuracy, and pharmaceutical use is effectively reduced, reduce bad and immunological rejection.The present invention can provide for user
The precise information of therapentic part helps to improve treatment accuracy, reduces error, also greatly facilitates user, improve
The operating characteristics of laser therapeutic apparantus.
The invention provides the following technical scheme:
A kind of laser therapeutic system of combination tumour cell detection, the system comprises based endoscopic imaging part and laser therapies
Part, the based endoscopic imaging part include visual light imaging part and fluorescent imaging moiety, and the fluorescent imaging moiety includes will
Tumour cell targeting specific fluorescence probe is applied to the drug delivery device of destination organization.
Preferably, the fluorescence probe includes polypeptide complex and fluorescent molecule, and the polypeptide complex passes through the key
It closes group and the fluorescent molecule is covalently attached.
The fluorescent molecule includes the centre of luminescence and clad；The centre of luminescence is rare earth upconversion nano crystal phosphor
Material；The clad contains azido group.
Preferably, the binding groups are alkynyl.
The laser therapy part includes laser light source, laser transmission fiber and laser probe, and what laser light source generated controls
Laser is treated to be emitted through laser probe.
Preferably, the laser therapy part uses thulium doped optical fiber laser source, and thulium doped optical fiber laser source generates 2 μm of laser,
Thulium-doped fiber laser is close with the absorption peak of water, has fabulous due to can provide wavelength in 2 μm or so of long wave laser generation
To tissue cutting and coagulating effectiveness, can be transmitted with ordinary optic fibre, be ideal surgical laser light source.
The fluorescent imaging moiety further includes near-infrared light source, and near infrared light is transmitted through optical fiber, for irradiating destination organization,
Activate the tumour cell targeting specific fluorescence probe.
Treating can be transmitted with 2 μm of laser, visible light, the near infrared light by same or different optical fiber of losing, institute
It states and loses optical fiber and enter inside of human body through endoscope.
Preferably, the dosed portions include endoscope-use syringe, and the endoscope-use syringe will be for that will include institute
The medicament for stating tumour cell targeting specific fluorescence probe is injected into the blood vessel on destination organization periphery.
The system also includes image display devices, for showing visible light and fluorescent image, described image display device
Visible light and fluorescent image can be shown simultaneously, fluorescent image can also be added on visible images, directly in visible light
Fluorescent spots are indicated on image.
Compared with prior art, beneficial effects of the present invention:
1, in laser therapy, the detection to tumour cell is realized using tumour cell targeting specific fluorescence probe, it is real
Now to the accurate mark of tumour cell, doctor is helped to distinguish normal tissue and tumour cell during surgery, realized to tumour cell
Accurate processing.
2, this system realizes that minimally invasive insertion type is directly administered using endoscope, realizes the accurate administration to target site,
Detection accuracy is greatly improved, and effectively reduces pharmaceutical use, reduces bad and immunological rejection.
3, the present invention has selected ligand and image forming material carrier of the preferable polypeptide of bio-compatibility as target, has target
The characteristic of more accurate position, good biocompatibility, low toxicity is demarcated, the introducing of cell-penetrating peptide is so that the delivery of image forming material is safer
Efficiently；Relative market similar product, the present invention is low in cost, is metabolized faster in targeting body.
4, polypeptide and rare earth upconversion nano crystal fluorescent material are used in combination, and small toxicity, chemical stability are high, light is stablized
Property it is good, fluorescent emission is high-efficient, accurate targeting to pathogenic sites such as tumours may be implemented and combine and fluorescence imaging.
Detailed description of the invention
Fig. 1 is laser therapeutic system overall construction drawing of the present invention；
In figure, 1- laser therapeutic system, 2- laser therapy part, 3- based endoscopic imaging part, 4- visual light imaging part, 5-
Fluorescent imaging moiety, 6- drug delivery device, 7- near-infrared light source.
Specific embodiment
In order to be more clear goal of the invention of the invention, technical solution and advantageous effects, with reference to embodiments,
The present invention will be described in further detail.It should be understood that embodiment described in this specification is just for the sake of explanation
The present invention, be not intended to limit the present invention, embodiment design parameter setting etc. can adaptation to local conditions make a choice and simultaneously to result
Without substantial effect.
Embodiment
As shown in Figure 1, the present invention provides a kind of laser therapeutic system 1 of combination tumour cell detection, the system 1 includes
Laser therapy part 2 and based endoscopic imaging part 3, the based endoscopic imaging part 3 include visual light imaging part 4 and fluorescence imaging portion
Divide 5, the fluorescent imaging moiety 5 includes the drug delivery device that tumour cell targeting specific fluorescence probe is applied to destination organization
6。
The fluorescence probe includes polypeptide complex and fluorescent molecule, the polypeptide complex by the binding groups with
The fluorescent molecule is covalently attached, and the polypeptide complex is using more described in patent document (publication number CN108815537A)
Peptide complexes.
The fluorescent molecule includes the centre of luminescence and clad；The centre of luminescence is rare earth upconversion nano crystal phosphor
Material；The clad contains azido group.
The binding groups are alkynyl.
The laser therapy part 2 includes laser light source, laser transmission fiber and laser probe, and what laser light source generated controls
Laser is treated to be emitted through laser probe.
The laser therapy part 2 uses thulium doped optical fiber laser source, and thulium doped optical fiber laser source generates 2 μm of laser, mixes thulium light
Fibre laser is close with the absorption peak of water, has fabulous to people due to can provide wavelength in 2 μm or so of long wave laser generation
Body tissue cutting and coagulating effectiveness, can be transmitted with ordinary optic fibre, be ideal surgical laser light source.
The fluorescent imaging moiety 5 further includes near-infrared light source 7, and near infrared light is transmitted through optical fiber, for irradiating target group
It knits, activates the tumour cell targeting specific fluorescence probe.
Treating can be transmitted with 2 μm of laser, visible light, the near infrared light by same or different optical fiber of losing, institute
It states and loses optical fiber and enter inside of human body through endoscope.
The dosed portions 6 include endoscope-use syringe, and the endoscope-use syringe will be for that will include the tumour
The medicament of cell-targeting specificity fluorescence probe is injected into the blood vessel on destination organization periphery.
The system also includes image display devices, for showing visible light and fluorescent image, described image display device
Visible light and fluorescent image can be shown simultaneously, fluorescent image can also be added on visible images, directly in visible light
Fluorescent spots are indicated on image.
The preferred embodiment of the patent is described in detail above, but this patent is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be under the premise of not departing from this patent objective
It makes a variety of changes.
Claims (9)
1. a kind of laser therapeutic system of combination tumour cell detection, which is characterized in that the system comprises based endoscopic imaging parts
And laser therapy part, the based endoscopic imaging part include visual light imaging part and fluorescent imaging moiety, the fluorescence imaging
Part includes the drug delivery device that tumour cell targeting specific fluorescence probe is applied to destination organization.
2. laser therapeutic system according to claim 1, which is characterized in that the fluorescence probe include polypeptide complex and
Fluorescent molecule, the polypeptide complex are covalently attached by the binding groups and the fluorescent molecule.
3. laser therapeutic system according to claim 2, which is characterized in that the binding groups are alkynyl.
4. laser therapeutic system according to claim 1, which is characterized in that the fluorescent molecule includes the centre of luminescence and packet
Coating；The centre of luminescence is rare earth upconversion nano crystal fluorescent material；The clad contains azido group.
5. laser therapeutic system according to claim 1, which is characterized in that the laser therapy part includes laser light
Source, laser transmission fiber and laser probe, the treatment laser that laser light source generates are emitted through laser probe.
6. laser therapeutic system according to claim 1, which is characterized in that the laser therapy part uses thulium doped fiber
Laser source.
7. laser therapeutic system according to claim 1, which is characterized in that the fluorescent imaging moiety further includes near-infrared
Light source.
8. laser therapeutic system according to claim 1, which is characterized in that the dosed portions include endoscope-use injection
Device.
9. laser therapeutic system according to claim 1, which is characterized in that the system also includes image display device,
For showing visible light and fluorescent image.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811500315.7A CN109567935A (en) | 2018-12-07 | 2018-12-07 | A kind of laser therapeutic system of combination tumour cell detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811500315.7A CN109567935A (en) | 2018-12-07 | 2018-12-07 | A kind of laser therapeutic system of combination tumour cell detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109567935A true CN109567935A (en) | 2019-04-05 |
Family
ID=65927840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811500315.7A Pending CN109567935A (en) | 2018-12-07 | 2018-12-07 | A kind of laser therapeutic system of combination tumour cell detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109567935A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772318A (en) * | 2019-11-06 | 2020-02-11 | 刁冬梅 | Tumor surgical resection system |
| CN111557676A (en) * | 2020-05-13 | 2020-08-21 | 山东省肿瘤防治研究院（山东省肿瘤医院） | System and equipment for dynamically adjusting target area position according to change of tumor in radiotherapy process |
| CN113616330A (en) * | 2021-08-30 | 2021-11-09 | 河南大学第一附属医院 | Laser intervention operation system for cutting tumor tissue |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1787778A (en) * | 2003-05-14 | 2006-06-14 | 光谱治疗股份公司 | Therapeutic and diagnostic systems and methods incorporating radiation distributing optics |
| CN103491847A (en) * | 2011-06-07 | 2014-01-01 | 奥林巴斯医疗株式会社 | Endoscope apparatus and light quantity control method for fluorescent light observation |
| CN104873268A (en) * | 2015-06-05 | 2015-09-02 | 湖南中聚光电科技发展有限公司 | Optical fiber laser scalpel |
| CN104873269A (en) * | 2015-06-05 | 2015-09-02 | 湖南中聚光电科技发展有限公司 | 2-micrometer optical fiber laser scalpel |
| CN105473049A (en) * | 2013-08-23 | 2016-04-06 | 奥林巴斯株式会社 | Fluorescence observation apparatus |
| CN108209842A (en) * | 2018-01-12 | 2018-06-29 | 广东欧谱曼迪科技有限公司 | A high-precision near-infrared fluorescence navigation endoscope system and its image registration method |
| CN108336637A (en) * | 2018-03-29 | 2018-07-27 | 上海瑞柯恩激光技术有限公司 | Medical thulium doped optical fiber laser therapeutic device |
| CN108338774A (en) * | 2018-04-17 | 2018-07-31 | 深圳大学 | It is a kind of to peep micro- photo-thermal therapy device and its operating method based on interior |
| CN108815537A (en) * | 2018-06-08 | 2018-11-16 | 华中科技大学 | A kind of tumour cell targeting specific fluorescence probe and the preparation method and application thereof |
-
2018
- 2018-12-07 CN CN201811500315.7A patent/CN109567935A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1787778A (en) * | 2003-05-14 | 2006-06-14 | 光谱治疗股份公司 | Therapeutic and diagnostic systems and methods incorporating radiation distributing optics |
| CN103491847A (en) * | 2011-06-07 | 2014-01-01 | 奥林巴斯医疗株式会社 | Endoscope apparatus and light quantity control method for fluorescent light observation |
| CN105473049A (en) * | 2013-08-23 | 2016-04-06 | 奥林巴斯株式会社 | Fluorescence observation apparatus |
| CN104873268A (en) * | 2015-06-05 | 2015-09-02 | 湖南中聚光电科技发展有限公司 | Optical fiber laser scalpel |
| CN104873269A (en) * | 2015-06-05 | 2015-09-02 | 湖南中聚光电科技发展有限公司 | 2-micrometer optical fiber laser scalpel |
| CN108209842A (en) * | 2018-01-12 | 2018-06-29 | 广东欧谱曼迪科技有限公司 | A high-precision near-infrared fluorescence navigation endoscope system and its image registration method |
| CN108336637A (en) * | 2018-03-29 | 2018-07-27 | 上海瑞柯恩激光技术有限公司 | Medical thulium doped optical fiber laser therapeutic device |
| CN108338774A (en) * | 2018-04-17 | 2018-07-31 | 深圳大学 | It is a kind of to peep micro- photo-thermal therapy device and its operating method based on interior |
| CN108815537A (en) * | 2018-06-08 | 2018-11-16 | 华中科技大学 | A kind of tumour cell targeting specific fluorescence probe and the preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 洪广言，庄卫东: "《稀土发光材料》", 31 May 2016, 冶金工业出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772318A (en) * | 2019-11-06 | 2020-02-11 | 刁冬梅 | Tumor surgical resection system |
| CN110772318B (en) * | 2019-11-06 | 2020-09-01 | 西安交通大学医学院第一附属医院 | A tumor surgical resection system |
| CN111557676A (en) * | 2020-05-13 | 2020-08-21 | 山东省肿瘤防治研究院（山东省肿瘤医院） | System and equipment for dynamically adjusting target area position according to change of tumor in radiotherapy process |
| CN111557676B (en) * | 2020-05-13 | 2023-12-19 | 山东省肿瘤防治研究院（山东省肿瘤医院） | Systems and equipment that dynamically adjust the target location according to changes in the tumor during radiotherapy |
| CN113616330A (en) * | 2021-08-30 | 2021-11-09 | 河南大学第一附属医院 | Laser intervention operation system for cutting tumor tissue |
| CN113616330B (en) * | 2021-08-30 | 2023-03-14 | 河南大学第一附属医院 | Laser intervention operation system for cutting tumor tissue |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bown | Phototherapy of tumors | |
| Bown | Photodynamic therapy for photochemists | |
| McCaughan Jr et al. | Palliation of esophageal malignancy with photoradiation therapy | |
| Patrice et al. | Endoscopic photodynamic therapy with hematoporphyrin derivative for primary treatment of gastrointestinal neoplasms in inoperable patients | |
| US11540720B2 (en) | Methods, software and systems for imaging | |
| US20030187427A1 (en) | Method and apparatus for in VIVO treatment of mammary ducts by light induced fluorescence | |
| KR20090094331A (en) | Abnormal electrical conduction-blocking apparatus using photodynamic therapy(pdt) | |
| Marcus | Photodynamic therapy of human cancer: clinical status, potential, and needs | |
| Deng et al. | A biodegradable, flexible photonic patch for in vivo phototherapy | |
| CN109567935A (en) | A kind of laser therapeutic system of combination tumour cell detection | |
| McCaughan Jr et al. | Palliation of esophageal malignancy with photodynamic therapy | |
| Filauro et al. | Office-based procedures in laryngology | |
| Jin et al. | Photodynamic therapy for upper gastrointestinal tumours over the past 10 years | |
| Meisgeier et al. | Wound healing after therapy of oral potentially malignant disorders with a 445-nm semiconductor laser: a randomized clinical trial | |
| CN114451866A (en) | Diagnosis and treatment system for early cancer in cervical canal and working method thereof | |
| Katzir | Optical fibers in medicine | |
| Liu et al. | High‐power 450 nm blue diode laser for endoscopic mucosal resection/endoscopic submucosal dissection in the stomach: Preliminary results on a porcine model with a modified flexible endoscope | |
| Grossweiner | Photodynamic therapy | |
| CN209361672U (en) | A laser prostate treatment system capable of stimulating autofluorescence | |
| Hermann et al. | Office‐based transurethral devascularisation of low grade non‐invasive urothelial cancer using diode laser. A feasibility study | |
| Friedberg | Photodynamic therapy for malignant pleural mesothelioma: the future of treatment? | |
| Satpathy et al. | NIR‐II fluorescent nanophosphors for bio‐imaging | |
| US11654195B2 (en) | Eco-friendly smart photosensitizer and photo-stem cell therapy product comprising same | |
| Nishioka | Applications of lasers in gastroenterology | |
| Andersson-Engels et al. | Photodynamic Therapy Alone Or In Conjunction With Near-Infrared Light-Induced Hyperthermia In Human Malignant Tumors. A Methodological Case Study |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190405 |
|
| RJ01 | Rejection of invention patent application after publication |