CN109549191A - A kind of fructus cannabis oil microcapsules and its preparation method and application - Google Patents
A kind of fructus cannabis oil microcapsules and its preparation method and application Download PDFInfo
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- CN109549191A CN109549191A CN201710882636.7A CN201710882636A CN109549191A CN 109549191 A CN109549191 A CN 109549191A CN 201710882636 A CN201710882636 A CN 201710882636A CN 109549191 A CN109549191 A CN 109549191A
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- wall material
- fructus cannabis
- cannabis oil
- protein
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- 102000004169 proteins and genes Human genes 0.000 claims abstract description 53
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 27
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 4
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
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- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 240000008564 Boehmeria nivea Species 0.000 description 1
- 235000008697 Cannabis sativa Nutrition 0.000 description 1
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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- 238000006701 autoxidation reaction Methods 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
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- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
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- 150000002148 esters Chemical class 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- SYUXAJSOZXEFPP-UHFFFAOYSA-N glutin Natural products COc1c(O)cc2OC(=CC(=O)c2c1O)c3ccccc3OC4OC(CO)C(O)C(O)C4O SYUXAJSOZXEFPP-UHFFFAOYSA-N 0.000 description 1
- 235000004280 healthy diet Nutrition 0.000 description 1
- 239000011487 hemp Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
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- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
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- 239000005720 sucrose Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
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- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Cosmetics (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
The present invention relates to microcapsules technology field, a kind of fructus cannabis oil microcapsules and its preparation method and application are disclosed.Fructus cannabis oil microcapsules of the present invention include fructus cannabis oil, wall material A and wall material B；Three kinds or more of the wall material A in whey protein isolate, casein, rapeseed protein, flax protein and rice residue protein；The wall material B is selected from least one of Arabic gum, maltodextrin, starch octenyl succinate anhydride, tapioca and cyclodextrin.The present invention is combined using specific protide wall material as one of fructus cannabis oil microcapsule wall material, cooperate with dextrin class, starch and gelatin substance wall material, so that the fructus cannabis oil microcapsules is had good stability and higher encapsulation rate and carry oil cut rate, is applied in relevant healthcare food or drug with more excellent quality.
Description
Technical field
The present invention relates to microcapsules technology fields, and in particular to a kind of fructus cannabis oil microcapsules and preparation method thereof and answers
With.
Background technique
Fructus cannabis also known as cannabis,fructus, hempseed, edestan, fiery pockmarks, pockmarks benevolence, are moraceae plants hemp (Cannabis
Sativa L.) fruit or remove pericarp kernel be classified as top grade first recorded in Shennong's Herbal.The cultivation history of fiery fiber crops is long-drawn-out
Long, the cultivated area of China's fire fiber crops and yield position are at the forefront in the world, but the scientific research in relation to fiery ramie product field much lags.Fire
Extract of the edestan oil as fiery numb dry mature fruit, is a kind of functional grease rich in unsaturated fatty acid, has wide
General edible and medical value, meets demand of the current people to healthy diet, can be used as a kind of new type functional oil plant money
Source is developed and used, and has good development and application prospect.
Fructus cannabis vegetable protein rich in, lecithin and the vitamin E largely to delay senescence, selenium, zinc, manganese, germanium etc.
The essential trace elements of the human body, fatty oil about 50% or so, wherein unsaturated fatty acid content is up to 85% or more, n-3 not
Saturated fatty acid alpha-linolenic acid content is about 20% or more, thus sensitive to oxygen, light and heat, is easy to produce oxidation, according to
Microcapsules technology can effectively delay the autoxidation process of unsaturated fatty acid, while carry out at microencapsulation to fructus cannabis oil
Reason, thus it is possible to vary its form makes its water-soluble and mobility enhancing, is convenient for storage and transport.
Current fructus cannabis oil micro capsule technology more considers the indexs such as embedding rate, surface oil content, peroxide value, and
The rare concern of mobility and dissolution dispersity for microcapsules, and according to actual production with detection the results show that current
The mobility and dissolution dispersity of fructus cannabis oil microcapsules are all poor, require further improvement preparation process.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of fructus cannabis oil microcapsules, so that the microcapsules have more
Excellent mobility and dissolution dispersity；
Another object of the present invention is that a kind of fructus cannabis oil microcapsules are provided, so that the microcapsules are with higher
Encapsulation rate, lower surface oil content and peroxide value；
Another object of the present invention is that provide above-mentioned fructus cannabis oil microcapsules preparation method and micro- glue
Related application of the capsule in drug and/or food.
For achieving the above object, the invention provides the following technical scheme:
A kind of fructus cannabis oil microcapsules, including fructus cannabis oil and wall material, the wall material are divided into wall material A and wall material B；The wall
Three kinds or more of the material A in whey protein isolate, casein, rapeseed protein, flax protein and rice residue protein；It is described
Wall material B is selected from least one of Arabic gum, maltodextrin, starch octenyl succinate anhydride, tapioca and cyclodextrin.
The present invention prepares micro- glue of fructus cannabis oil using multiple protein and dextrin class, starch and gelatin substance as wall material
Capsule can significantly improve the powder fluidity and dissolubility of fructus cannabis oil compared to conventional wall material type, just with subsequent preparation at
Type (application of such as solid beverage).
Preferably, the fructus cannabis oil and the mass ratio of wall material are 1:(2~4)；In the specific embodiment of the invention,
The fructus cannabis oil and the mass ratio of wall material are 1:2,1:3 or 1:4.
Preferably, the mass ratio of the wall material A and wall material B is (1~3): (1~3)；In the specific embodiment of the invention
In, the mass ratio of the wall material A and wall material B are 3:1,2:1,1:1,1:2 or 1:3.
The restriction of the wall material A according to the present invention, is preferably at least whey protein isolate, casein and rapeseed protein
Three kinds, i.e., be following four kinds of situations in the specific implementation process:
(1) whey protein isolate, casein and three kinds of rapeseed protein；
(2) whey protein isolate, casein, rapeseed protein and four kinds of flax protein；
(3) whey protein isolate, casein, rapeseed protein and four kinds of rice residue protein；
(4) whey protein isolate, casein, rapeseed protein, flax protein and five kinds of rice residue protein；
Preferably, the whey protein isolate, casein, rapeseed protein, flax protein and rice residue protein mass ratio
For (1~5): (1~2): (1~3): (0~2): (0~3), wherein the ratio of flax protein and/or rice residue protein is accepted or rejected or
Adjustment can respectively correspond the composition situation of above-mentioned four kinds of wall material A.
In the specific embodiment of the invention, the wall material A is selected from combination A (whey protein isolate, casein and vegetable seed egg
White, mass ratio 4:1:1,3:2:2,5:1:3 or 2:2:1), combination B (whey protein isolate, casein, rapeseed protein and flax
Albumen, mass ratio 3:1:2:2), combination C (whey protein isolate, casein, rapeseed protein and rice residue protein, mass ratio 3:
2:1:2:2), combine D (whey protein isolate, casein, rapeseed protein, flax protein and rice residue protein, mass ratio 5:1:1:
2:3).
In the specific embodiment of the invention, the wall material B is selected from maltodextrin, starch octenyl succinate anhydride or ring paste
Essence.
Preferably, fructus cannabis oil microcapsules of the present invention further include antioxidant, can be selected from tocopherol acetate,
At least one of ascorbyl palmitate, Rosmarinus officinalis extract and fat-soluble tea polyphenol；In a specific embodiment, described
Antioxidant is tocopherol acetate.
Preferably, the antioxidant accounts for 0.1 ‰~the 0.5% of fructus cannabis oil microcapsules gross weight；In specific embodiment party
In formula, the antioxidant accounts for the 0.3 ‰ of fructus cannabis oil microcapsules gross weight.
The encapsulation rate of fructus cannabis oil microcapsules of the present invention can reach 98% or more, carry oil cut rate 30% or so, surface oil
Content is less than 1%, and peroxide value is not higher than 38 ° between 1.6-1.7mmol/kg, mobility angle of repose, and the dissolution dispersity time is not
Higher than 10s；Relative to the control microcapsules of other different wall materials, the present invention is significantly better than control in the effect of above-mentioned various aspects
Microcapsules illustrate that fructus cannabis oil microcapsules of the invention have preferable stablize especially in mobility and dissolution dispersity
Property, mobility and dissolution dispersity.Based on above-mentioned excellent technical effect, the invention proposes the microcapsules to prepare food
And/or the application in drug.
Meanwhile the present invention also provides the preparation methods of the microcapsules, comprising:
Step 1, by wall material A and water mixed dissolution, carry out pressurized treatments, obtain solution A；By wall material B and water mixed dissolution
And solution A is added, obtain wall material solution；
Step 2 mixes wall material solution with fructus cannabis oil, obtains colostric fluid by high speed shearing emulsification；
Colostric fluid is carried out super-high-pressure homogenization processing by step 3, is prepared into the lotion of Nano grade.
Step 4, the emulsion spray of Nano grade are dry, obtain fructus cannabis oil microcapsules.
Wherein, the mass ratio and the wall material B of the wall material A and water and the mass ratio of water are (3~9): (7~
11)；The temperature of water is preferably 40~60 DEG C.
Preferably, further including that antioxidant is added in step 2, mixed together with wall material solution, fructus cannabis oil.
In addition, during the preparation process, the present invention provides each technological parameter, in step 1 pressurized treatments be 200~
Pressurized treatments 10-20min under 600MPa pressure value；Step 2 high speed emulsification pretreatment speed is 6000~25000rpm, when emulsification
Between be 1-15 minutes；The parameter of super-high-pressure homogenization technique is 10000psi~30000psi in step 3；Step 3 is spray-dried item
Part are as follows: 0.1~0.4MPa of atomisation pressure, 110~130 DEG C of inlet air temperature, charging rate is 30~60L/h.
From the above technical scheme, the present invention is combined using specific protide wall material as fructus cannabis oil microcapsule wall material
One of, collaboration dextrin class, starch and gelatin substance wall material, make the fructus cannabis oil microcapsules have good stability with
And higher encapsulation rate and carry oil cut rate, be applied in relevant healthcare food or drug with more excellent quality.
Specific embodiment
The invention discloses a kind of fructus cannabis oil microcapsules and its preparation method and application, and those skilled in the art can borrow
Reflect present disclosure, is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to this field
It is it will be apparent that they are considered as being included in the present invention for technical staff.Microcapsules of the present invention and its preparation side
Method and application are described by embodiment, and related personnel can obviously not depart from the content of present invention, spirit and scope
It is interior that method described herein and application are modified or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
If not otherwise specified, fructus cannabis oil employed in the specific embodiment of the invention and each wall material raw material are all made of phase
With the raw material in source and quality, preparation process and comparative test condition are compared in addition to due difference, remaining is consistent.
In the present invention, it is related to the detection of some indexs, can refer to as follows:
Determination of POV according to GB 5009.227 method；Acid value determination according to GB 5009.229 method；It is aqueous
Measure the fixed method according to GB 5009.3.
Surface oil: the free oil mass of surface oil, that is, fructus cannabis oil surface of microcapsule accounts for the total weight of the fructus cannabis oil microcapsules
Percentage.Fructus cannabis oil surface of microcapsule oil is soluble in petroleum ether (30~60 DEG C of boiling range), and microcapsules other compositions are insoluble
In petroleum ether, using the i.e. separable surface oil of petroleum ether and microcapsules, to obtain surface oil weight.
The measuring method of surface oil are as follows:
It weighs fructus cannabis oil microcapsules sample 5g and (accurately to 0.002g) in 50ml centrifuge tube, 30ml petroleum ether is added
(30~60 DEG C of boiling range), be vortexed concussion 5 minutes, filtering, and filtrate is placed in that drying to constant weight in 105 DEG C of baking ovens in advance (accurately extremely
In 100ml round-bottomed flask 0.002g).Filter residue is transferred in centrifuge tube, and petroleum ether is added, and the concussion that is vortexed washes twice, every time
Petroleum ether additional amount is 10ml；Filtering, merging filtrate to above-mentioned round-bottomed flask, 35 DEG C of vacuum rotatings are evaporated petroleum ether, then at 105
Drying to constant weight in DEG C constant temperature oven, cooling, weighing.
X (%)=(W1-W2)/W × 100%
In formula: surface oil content, % in X- grease microcapsule
W- sample mass, g
The weight of evaporating dish, g after W1- constant weight
The weight of evaporating dish and leaching oil, g after W2- constant weight.
The measurement of total oil content amount is referring to the acid-hydrolysis method in GB/T 5009.6.
Embedding rate is calculated according to the following formula:
The measurement (funnel method) at angle of repose:
The culture dish that a diameter is 6cm is put in bottom, and funnel is fixed on iron stand, makes the distance between funnel and culture dish
For 10cm, powder 10g is weighed, powder is fallen above funnel, is gradually accumulated in culture dish after funnel buffers, forms cone
Body.Until obtaining highest cone, a height of h of the cone and radius r of conical bottom circle is measured.Find out angle of repose
α is averaged in triplicate.Calculation formula are as follows:
Tan α=h/r
Dispersed measurement experiment: weighing sample 5g, 25 DEG C is dissolved in, in 50mL deionized water, in constant temperature blender with magnetic force
It is stirred with certain revolving speed, the time required to record all disperses since stirring to powdered oil agglomeration tissue；Repeat test 3
It is secondary, its average value is taken, this value is as jitter time (s).
DT=(t1+t2+t3)/3
In formula, ST- jitter time, s；T1- first time jitter time, s；Second of jitter time of t2-, s；T3- third time
Jitter time, s.
Jitter time is shorter to show powdered oil not easy to knot groups in water, being capable of quickly uniformly diffusion in water.
In the testing result of the embodiment of the present invention and each comparative example, the encapsulation rate of microcapsules of the present invention can
Reach 98% or more, and the encapsulation rate of comparative example 1-5 is in 80-90%；The surface oil content of microcapsules of the present invention does not surpass
1% is crossed, and comparative example 1-5 has been more than 3%；The peroxide value of microcapsules of the present invention between 1.6-1.7mmol/kg, and
Each comparative example peroxide value has been more than 2.8mmol/kg；The angle of repose of microcapsules of the present invention is not higher than 38 °, and comparative example
The angle of repose of 1-6 is more than 48 °；Dissolution dispersity time of microcapsules of the present invention is not higher than 10s, and comparative example 1-6
Dissolution dispersity is the results show that time up to 60s or more is even more than 100s, and the insoluble object that the presence having can not disperse
Matter.
Just a kind of fructus cannabis oil microcapsules provided by the present invention and its preparation method and application are described further below.
Embodiment 1: fructus cannabis oil microcapsules of the present invention are prepared
(1) prepare wall material solution: by wall material A (whey protein isolate, casein, rapeseed protein mass ratio be 4:1:1)
It is dissolved in water, 400MPa pressurized treatments 10min obtains solution A；Wall material B (starch octenyl succinate anhydride) is dissolved in water and is added molten
In liquid A, the mass ratio of wall material A and wall material B are 3:1, are prepared into the wall material solution that solid content is 30%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 3:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 35%,
10000rpm high speed shear is handled 1 minute, obtains colostric fluid；
(3) nanoemulsions are prepared: colostric fluid being subjected to super-high-pressure homogenization processing (12000Psi), is prepared into Nano grade
Lotion；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
110 DEG C, charging rate 30L/h, obtain fructus cannabis oil microcapsules.
It is 98.8% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 0.4%, and peroxide value is
1.64mmol/kg, angle of repose are 31 °, and dispersed measurement experiment is 5s.
Embodiment 2: fructus cannabis oil microcapsules of the present invention are prepared
(1) wall material solution is prepared: by the wall material A (quality of whey protein isolate, casein, rapeseed protein and flax protein
Than being dissolved in water for 3:1:2:2), 400MPa pressurized treatments 10min obtains solution A；Wall material B (starch octenyl succinate anhydride) is molten
It in water and is added in solution A, the mass ratio of wall material A and wall material B are 2:1, are prepared into the wall material solution that solid content is 30%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 3:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 35%,
10000rpm high speed shear is handled 1 minute, obtains colostric fluid；
(3) nanoemulsions are prepared: colostric fluid being subjected to super-high-pressure homogenization processing (12000Psi), is prepared into Nano grade
Lotion；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
110 DEG C, charging rate 30L/h, obtain fructus cannabis oil microcapsules.
It is 98.8% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 0.4%, and peroxide value is
1.62mmol/kg, angle of repose are 35 °, and dispersed measurement experiment is 9s.
Embodiment 3: fructus cannabis oil microcapsules of the present invention are prepared
(1) wall material solution is prepared: by wall material A (whey protein isolate, casein, rapeseed protein, flax protein and rice residue egg
White mass ratio is 3:2:1:2:2) it is dissolved in water, 400MPa pressurized treatments 10min obtains solution A；By wall material B (octenyl succinic
Acid-starch ester) it is dissolved in water and is added in solution A, the mass ratio of wall material A and wall material B are 1:1, and being prepared into solid content is 30%
Wall material solution；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 3:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 35%,
10000rpm high speed shear is handled 1 minute, obtains colostric fluid；
(3) nanoemulsions are prepared: colostric fluid being subjected to super-high-pressure homogenization processing (12000Psi), is prepared into Nano grade
Lotion；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
110 DEG C, charging rate 30L/h, obtain fructus cannabis oil microcapsules.
It is 98.8% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 0.4%, and peroxide value is
1.65mmol/kg, angle of repose are 38 °, and dispersed measurement experiment is 10s.
Embodiment 4: fructus cannabis oil microcapsules of the present invention are prepared
(1) prepare wall material solution: by wall material A (whey protein isolate, casein, rapeseed protein mass ratio be 3:2:2)
It is dissolved in water, 600MPa pressurized treatments 10min obtains solution A；Wall material B (maltodextrin) is dissolved in water and is added in solution A, wall material
The mass ratio of A and wall material B is 1:2, is prepared into the wall material solution that solid content is 35%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 2:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 40%,
10000rpm high speed shear is handled 1 minute, obtains colostric fluid；
(3) nanoemulsions are prepared: colostric fluid being subjected to super-high-pressure homogenization processing (12000Psi), is prepared into Nano grade
Lotion；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
120 DEG C, charging rate 30L/h, obtain fructus cannabis oil microcapsules.
It is 98.2% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 0.6%, and peroxide value is
1.61mmol/kg, angle of repose are 33 °, and dispersed measurement experiment is 6s.
Embodiment 5: fructus cannabis oil microcapsules of the present invention are prepared
(1) wall material solution is prepared: by wall material A (whey protein isolate, casein, rapeseed protein, flax protein, rice residue egg
White mass ratio is 5:1:1:2:3) it is dissolved in water, 600MPa pressurized treatments 10min obtains solution A；Wall material B (maltodextrin) is dissolved in
Water is simultaneously added in solution A, and the mass ratio of wall material A and wall material B are 1:2, is prepared into the wall material solution that solid content is 35%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 2:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 40%,
10000rpm high speed shear is handled 1.5 minutes, obtains colostric fluid；
(3) nanoemulsions are prepared: colostric fluid being subjected to super-high-pressure homogenization processing (15000Psi), is prepared into Nano grade
Lotion；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
120 DEG C, charging rate 30L/h, obtain fructus cannabis oil microcapsules.
It is 98.4% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 0.5%, and peroxide value is
1.67mmol/kg, angle of repose are 38 °, and dispersed measurement experiment is 9s.
Embodiment 6: fructus cannabis oil microcapsules of the present invention are prepared
(1) prepare wall material solution: by wall material A (whey protein isolate, casein, rapeseed protein mass ratio be 5:1:3)
It is dissolved in water, 500MPa pressurized treatments 10min obtains solution A；Wall material B (cyclodextrin) is dissolved in water and is added in solution A, wall material A
Mass ratio with wall material B is 1:2, is prepared into the wall material solution that solid content is 35%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 2:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 40%,
12000rpm high speed shear is handled 1.5 minutes, obtains colostric fluid；
(3) nanoemulsions are prepared: colostric fluid being subjected to super-high-pressure homogenization processing (15000Psi), is prepared into Nano grade
Lotion；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
120 DEG C, charging rate 30L/h, obtain fructus cannabis oil microcapsules.
It is 98% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 0.8%, peroxide value 1.63mmol/
Kg, angle of repose are 37 °, and dispersed measurement experiment is 10s.
Embodiment 7: fructus cannabis oil microcapsules of the present invention are prepared
(1) prepare wall material solution: by wall material A (whey protein isolate, casein, rapeseed protein mass ratio be 2:2:1)
It is dissolved in water, 500MPa pressurized treatments 10min obtains solution A；Wall material B (maltodextrin) is dissolved in water and is added in solution A, wall material
The mass ratio of A and wall material B is 1:2, is prepared into the wall material solution that solid content is 35%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 2:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 40%,
13000rpm high speed shear is handled 1.5 minutes, obtains colostric fluid；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
120 DEG C, charging rate 40L/h.Obtain fructus cannabis oil microcapsules；
It is 98.3% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 0.7%, and peroxide value is
1.62mmol/kg, angle of repose are 37 °, and dispersed measurement experiment is 9s.
Comparative example 1:
(1) it prepares wall material solution: wall material A (rapeseed protein) being dissolved in water, 500MPa pressurized treatments 10min obtains solution A；
Wall material B (maltodextrin) is dissolved in water and is added in solution A, the mass ratio of wall material A and wall material B are 1:2, are prepared into solid content and contain
The wall material solution that amount is 35%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 2:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 40%,
13000rpm high speed shear is handled 1.5 minutes, obtains colostric fluid；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
120 DEG C, charging rate 40L/h.Obtain fructus cannabis oil microcapsules；
It is 78.3% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 5.7%, and peroxide value is
3.62mmol/kg, angle of repose are 48 °, and dispersed measurement experiment is 88s.
Comparative example 2:
(1) prepare wall material solution: by wall material A (casein, rice residue protein mass ratio be 2:1) be dissolved in water, 500MPa adds
Pressure processing 10min obtains solution A；Wall material B (maltodextrin) is dissolved in water and is added in solution A, the quality of wall material A and wall material B
The wall material solution for being 35% than for 1:2, being prepared into solid content；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 2:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 40%,
13000rpm high speed shear is handled 1.5 minutes, obtains colostric fluid；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
120 DEG C, charging rate 40L/h.Obtain fructus cannabis oil microcapsules；
It is 81.3% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 3.7%, and peroxide value is
2.89mmol/kg, angle of repose: 55 °；Dispersed measurement experiment still has insoluble matter after being 120s and can not dissolve always.
Comparative example 3:
(1) it prepares wall material solution: wall material A (converted starch) being dissolved in water, 500MPa pressurized treatments 10min obtains solution A；
Wall material B (maltodextrin) is dissolved in water and is added in solution A, the mass ratio of wall material A and wall material B are 1:2, are prepared into solid content and contain
The wall material solution that amount is 35%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 2:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 40%,
13000rpm high speed shear is handled 1.5 minutes, obtains colostric fluid；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
120 DEG C, charging rate 40L/h.Obtain fructus cannabis oil microcapsules；
It is 80.2% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 4.7%, and peroxide value is
4.27mmol/kg, angle of repose are 53 °, and dispersed measurement experiment is 109s.
Comparative example 4:
(1) wall material solution is prepared: by wall material A (whey protein isolate, wheat gluten, glutin, flax protein, rice residue
Albumen quality ratio is 5:1:1:2:3) it is dissolved in water, 500MPa pressurized treatments 10min obtains solution A；Wall material B (maltodextrin) is molten
It in water and is added in solution A, the mass ratio of wall material A and wall material B are 1:2, are prepared into the wall material solution that solid content is 35%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 2:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 40%,
13000rpm high speed shear is handled 1.5 minutes, obtains colostric fluid；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
120 DEG C, charging rate 40L/h.Obtain fructus cannabis oil microcapsules；
It is 85.3% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 3.1%, and peroxide value is
3.33mmol/kg, angle of repose are 51 °, and dispersed measurement experiment is 98s.
Comparative example 5:
(1) it prepares wall material solution: wall material A (soybean protein isolate, casein, rapeseed protein, mass ratio 4:1:1) is dissolved in
Water, 500MPa pressurized treatments 10min obtain solution A；Wall material B (maltodextrin) is dissolved in water and is added in solution A, wall material A with
The mass ratio of wall material B is 1:2, is prepared into the wall material solution that solid content is 35%；
(2) it prepares colostric fluid: fructus cannabis oil and tocopherol acetate being added in wall material solution, wherein wall material and fructus cannabis
The ratio of oil is 2:1, and tocopherol acetate additive amount is 0.3 ‰, and water is added to be made into the emulsion of solid content 40%,
13000rpm high speed shear is handled 1.5 minutes, obtains colostric fluid；
(4) dry: lotion obtained in step (3) is subjected to low temperature spray drying, atomisation pressure 0.3MPa, inlet air temperature
120 DEG C, charging rate 40L/h.Obtain fructus cannabis oil microcapsules；
It is 85.2% that the microcapsule embedded rate of fructus cannabis oil, which is made, surface oil content 3.0%, and peroxide value is
2.99mmol/kg, angle of repose are 49 °, and dispersed measurement experiment is 86s.
Comparative example 6:
(1) wall material solution is prepared: with maltodextrin 45%, converted starch 30%, Arabic gum 9%, 3% and of beta-cyclodextrin
Sucrose 13% is wall material, at room temperature, is added in material-compound tank, as the wall material solution that solid content is 50% is made in water.
(2) sterilize: wall material solution is gone out mattress 30min in 85 DEG C of water-baths.
(3) it emulsifies: after the wall material solution after sterilizing is cooled to 50 DEG C, being mixed with fructus cannabis oil, wherein wall material and fire fiber crops
Benevolence oil quality ratio is 1:1.5, stirs 15min, mixes well it, water is added to be made into the emulsion of solid content 50%.
(4) high-pressure homogeneous: the emulsion high pressure homogenizer that step (3) is obtained is with pressure 30MPa (300bar) homogeneous 2
It is secondary, then with pressure 60MPa (600bar) homogeneous 2 times, obtain the emulsion of stable homogeneous, 50 DEG C of heat preservation 60min.
(5)) be spray-dried: the emulsion that step (4) is obtained is spray-dried, atomizer rotating speed 16000rpm/min,
190 DEG C of inlet air temperature, 90 DEG C of leaving air temp, 75 DEG C of feeding temperature, charging rate 40L/h obtains fructus cannabis oil microcapsules, adds
Add 0.3% silica.
As a result: the peroxide value 0.069g/100g of obtained fructus cannabis oil microcapsules, acid value 0.43mg/g, water content
0.92%, oil content 50%, surface oil 0.52%, embedding rate 98.96%, yield 87.69%, angle of repose is 53 °, point
Dissipating property measurement experiment is 65s.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (12)
1. a kind of fructus cannabis oil microcapsules, which is characterized in that including fructus cannabis oil and wall material, the wall material is divided into wall material A and wall
Material B；Three kinds or three in whey protein isolate, casein, rapeseed protein, flax protein and rice residue protein of the wall material A
Kind or more；The wall material B is in Arabic gum, maltodextrin, starch octenyl succinate anhydride, tapioca and cyclodextrin
It is at least one.
2. fructus cannabis oil microcapsules according to claim 1, which is characterized in that the fructus cannabis oil and the mass ratio of wall material are
1:(2~4).
3. fructus cannabis oil microcapsules according to claim 1, which is characterized in that the mass ratio of the wall material A and wall material B is (1
~3): (1~3).
4. according to claim 1 or the 3 fructus cannabis oil microcapsules, which is characterized in that the wall material A be whey protein isolate,
Casein and three kinds of rapeseed protein；Whey protein isolate, casein, rapeseed protein and four kinds of flax protein；Whey protein isolate,
Casein, rapeseed protein and four kinds of rice residue protein；Or whey protein isolate, casein, rapeseed protein, flax protein and rice residue egg
White five kinds.
5. fructus cannabis oil microcapsules according to claim 4, which is characterized in that the whey protein isolate, casein, vegetable seed
The mass ratio of albumen, flax protein and rice residue protein is (1~5): (1~2): (1~3): (0~2): (0~3).
6. fructus cannabis oil microcapsules according to claim 1, which is characterized in that further include antioxidant.
7. fructus cannabis oil microcapsules according to claim 6, which is characterized in that the antioxidant be tocopherol acetate,
At least one of ascorbyl palmitate, Rosmarinus officinalis extract and fat-soluble tea polyphenol.
8. fructus cannabis oil microcapsules described according to claim 6 or 7, which is characterized in that it is micro- that the antioxidant accounts for fructus cannabis oil
0.1 ‰~the 0.5% of total capsule weight.
9. fructus cannabis oil microcapsules described in claim 1-8 any one are preparing the application in food and/or drug.
10. the preparation method of fructus cannabis oil microcapsules described in claim 1 characterized by comprising
Step 1, by wall material A and water mixed dissolution, carry out pressurized treatments, obtain solution A；By wall material B and water mixed dissolution and add
Enter solution A, obtains wall material solution；
Step 2 mixes wall material solution with fructus cannabis oil, obtains colostric fluid by high speed shearing emulsification；
Colostric fluid is carried out super-high-pressure homogenization processing by step 3, is prepared into the lotion of Nano grade；
Step 4, the emulsion spray of Nano grade are dry, obtain fructus cannabis oil microcapsules.
11. preparation method according to claim 10, which is characterized in that the mass ratio and the wall of the wall material A and water
The mass ratio of material B and water is (3~9): (7~11).
12. preparation method according to claim 10, which is characterized in that further include that antioxidant is added in step 2, with wall material
Solution, fructus cannabis oil mix together.
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| CN114847359A (en) * | 2022-04-20 | 2022-08-05 | 无锡励成医学营养有限公司 | Microcapsule type fat powder for diabetes food and preparation method and application thereof |
| CN117981873A (en) * | 2024-01-31 | 2024-05-07 | 新疆农垦科学院 | Chili seed oil microcapsule and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114271499A (en) * | 2021-12-29 | 2022-04-05 | 江南大学 | A kind of microcapsule powder with high embedding rate and preparation method thereof |
| CN114847359A (en) * | 2022-04-20 | 2022-08-05 | 无锡励成医学营养有限公司 | Microcapsule type fat powder for diabetes food and preparation method and application thereof |
| CN117981873A (en) * | 2024-01-31 | 2024-05-07 | 新疆农垦科学院 | Chili seed oil microcapsule and preparation method thereof |
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