CN109363676B

CN109363676B - Double-breast symmetry detection method for breast electrical impedance scanning imaging

Info

Publication number: CN109363676B
Application number: CN201811172339.4A
Authority: CN
Inventors: 季振宇; 董秀珍; 马航; 史学涛; 付峰
Original assignee: Fourth Military Medical University FMMU
Current assignee: Air Force Medical University
Priority date: 2018-10-09
Filing date: 2018-10-09
Publication date: 2022-03-29
Anticipated expiration: 2038-10-09
Also published as: CN109363676A

Abstract

The invention discloses a double breast symmetry detection method for breast electrical impedance scanning imaging. First, standardized positioning and area division are carried out on the breast surface, and according to the divided area numbers, the whole breast detection is completed by moving a probe to obtain the corresponding detection area. Serial detection data; further, based on the measurement data obtained in different regions, the whole breast impedance distribution information of unilateral breast is reconstructed by fitting the data at the boundary of the region; finally, based on the whole breast impedance distribution information of bilateral breasts , and use the similarity measure method to analyze the characteristics of the symmetry region. This method introduces the idea of double breast symmetry analysis into breast electrical impedance scanning imaging technology, and establishes a regional symmetry feature analysis method for double breast electrical impedance distribution, which can provide auxiliary discrimination information for breast electrical impedance scanning imaging technology inspection and improve diagnosis. Accuracy.

Description

Double-breast symmetry detection method for breast electrical impedance scanning imaging

Technical Field

The invention relates to a mammary gland impedance detection method, in particular to a double-mammary gland symmetry detection method for mammary gland impedance scanning imaging.

Background

The breast is a symmetric organ of a human body, and in clinical breast health examination (such as palpation, breast X-ray molybdenum target and the like), the breast diseases are often determined in an auxiliary manner by using symmetric analysis of anatomical structures and physiological characteristics of bilateral breast tissues so as to improve the accuracy of determination.

The breast Electrical Impedance Scanning imaging (EIS) technology utilizes the principle that the Electrical Impedance characteristics of a lesion tissue and a normal tissue are different, the health state of the tissue in a detection probe region is judged by acquiring the distribution characteristics of the Electrical Impedance of the tissue under the detection probe, and an operator can realize the health examination of the whole breast by gradually moving the handheld probe. In the study of electrical impedance scanning imaging of mammary gland, researchers focus on how to effectively extract and analyze information data in the detection probe region. However, if the thought method of the double-milk symmetry characteristic analysis is introduced into the EIS detection analysis and the symmetry characteristic information of the impedance distribution of the double milk is fully utilized, richer discrimination information is provided for the EIS, and the detection precision is improved. The EIS adopts a detection mode of a handheld probe, which brings certain difficulty for realizing the symmetry detection of the double breasts. The reason for this is that:

1) images acquired by the probe at a time are all local tissue state information (under the coverage area of the probe) of the breast, impedance distribution information of the whole breast cannot be directly acquired, and the symmetric characteristic contrast analysis of the double breast is not facilitated;

2) the probe is moved in a handheld mode, the detection probe needs to be accurately positioned in a symmetrical area of the contralateral breast, the operation experience is high in requirement, and the difficulty is high.

In the research process, the applicant finds that the idea of double-breast symmetry characteristic analysis is introduced into mammary gland Electrical Impedance Scanning (EIS), so that more auxiliary information is hopefully provided for EIS to analyze the inspection result, and the detection accuracy of EIS is improved. However, the handheld probe detection method adopted by the EIS cannot intuitively obtain the impedance state information of the whole milk tissue, and is not beneficial to realizing the contrast detection of the symmetry of the double milk.

Therefore, the study on a method for detecting the symmetry of the double breasts by electrical impedance scanning imaging of the mammary gland aims to overcome the defects of a handheld probe detection method, realize the symmetry detection of the double breasts by utilizing the impedance distribution information of the whole breasts on the basis of accurately positioning a detection area, improve the EIS detection efficiency and improve the accuracy of the EIS detection, and is always a technical problem concerned by the applicant.

Disclosure of Invention

The invention aims to provide a method for realizing double-breast symmetry detection in mammary gland EIS, which comprises the steps of accurately dividing the areas of two breasts by using a light grid positioning scale, and obtaining a plurality of groups of detection results corresponding to the detection areas after completing the breast detection in areas by using a movable probe. The detection results of different areas of the single-side breast are processed to reconstruct the full-breast impedance distribution data of the single-side breast, and the area positioning information and the full-breast impedance distribution information are further utilized to realize the symmetric detection of double breasts, thereby being beneficial to improving the detection accuracy of EIS.

In order to realize the task, the invention adopts the following technical solutions:

a double-breast symmetry detection method for breast electrical impedance scanning imaging is characterized by comprising the following steps:

before EIS detection, performing regional division on bilateral breasts by using a standardized positioning and regional division method;

step two, according to the areas divided on the surface of the breast, the mobile EIS detection probe is used for completing the detection of different areas of the breast one by one, a series of detection data corresponding to the detection areas are obtained, and the detection data of the different areas are used for reconstructing the full-breast impedance distribution information of the breast on one side;

and thirdly, carrying out symmetry characteristic analysis on the bilateral breasts by combining the area positioning information and the whole breast impedance distribution information.

According to the present invention, the method for performing segmentation of bilateral breasts by using the standardized localization and segmentation method before EIS detection in the first step is implemented as follows:

(1) the subject lies flat and exposes double breasts, selects the xiphoid process as a reference point and the sternum as a central axis, and establishes a reference coordinate system;

(2) according to the area of the unilateral breast, the light source is adjusted to project N multiplied by N light grids on the breast, the area of each light grid is equivalent to that of the detection electrode, and the total area of the light grids can cover the breast. Recording the adjusting parameters of the light source;

(3) and (3) symmetrically projecting the reference point of the xiphoid process and the central axis of the sternum to the breast on the other side according to the light source parameters adjusted in the step (2) so as to divide the detection area of the breast on the other side.

Furthermore, the implementation method of completing the examination of different areas of the breast one by using the mobile EIS detection probe according to the divided areas and reconstructing the full-breast impedance distribution information of the single-side breast by using the detection data of the different areas in the step two is as follows:

(1) the regions of the breast partition are numbered and the order of detection by the probe is specified.

(2) The detection is performed in a predetermined order, and when the detection of a certain area is completed, the area number and the detection result are recorded at the same time.

(3) And splicing the detection data of the plurality of areas according to the serial number sequence of the detection areas, performing fitting processing on the data at the junction of the detection areas, and reconstructing the full-breast impedance distribution data of the breast at one side according to the method.

The implementation method for carrying out the symmetry characteristic analysis of the bilateral breasts by combining the region positioning information and the whole breast impedance distribution information comprises the following steps:

(1) and searching suspicious regions of the single-side breast whole milk impedance distribution information data, and judging whether the suspicious regions exist.

(2) If the suspicious region A is found in the unilateral breast, the symmetrical region A of the contralateral breast is determined according to the position coordinate information of the suspicious region A_Symmetry. And for area A and area A_SymmetryThe electrical impedance parameter distribution characteristics of (a) are subjected to similarity measurement.

(3) If no suspicious region is searched, the impedance data of the double breasts can be symmetrically divided into N multiplied by N regions respectively, the similarity measurement of the impedance parameters is carried out on the corresponding regions, and the health state of the breasts is estimated and judged by calculating the similarity measurement parameters.

The similarity measurement method is used for carrying out difference analysis on the overall level characteristics of the impedance parameters in the region, such as the difference of the mean level of the impedance parameters; or performing similarity analysis on distribution characteristics of the impedance parameters in the region, such as correlation analysis or Babbitt distance analysis.

The invention relates to a method for detecting the symmetry of double breasts by mammary gland electrical impedance scanning imaging, which introduces the idea of analyzing the symmetry characteristics of the double breasts into the mammary gland electrical impedance scanning imaging technology and realizes the symmetry detection and the characteristic analysis of the double breasts by the technologies of standardized detection region positioning, full-breast impedance information reconstruction, similarity measurement of the symmetrical regions of the double breasts and the like. In practical application, the method can provide a new auxiliary discrimination method for the mammary gland electrical impedance imaging technology, and has important significance for improving the detection precision.

Drawings

FIG. 1 is a schematic diagram of standardized segmentation and localization of a breast prior to electrical impedance scanning detection of the breast.

Fig. 2 is a schematic diagram of double breast partitioning and numbering.

Fig. 3 is a schematic diagram of single-sided breast full milk information reconstruction.

Fig. 4 is a flow chart of a method for detecting contralateral double breast sex for electrical impedance scanning imaging of the breast.

Fig. 5 is a schematic diagram of full breast impedance distribution information gray scale mapping and suspicious region labeling.

FIG. 6 is a graph showing the results of similarity measurement using the Papanicolaou distance.

The present invention will be described in further detail with reference to the following drawings and examples.

Detailed Description

To further illustrate the features and advantageous characteristics of the present invention, the present embodiment provides a method for detecting the symmetry of breast in a double breast by electrical impedance scanning imaging.

It should be noted that the following examples are only for facilitating understanding of the present invention, and the present invention is not limited to the examples, and those skilled in the art should make modifications, additions and substitutions according to the technical scheme of the present invention.

The method for detecting the double-breast symmetry of the breast impedance scanning (EIS) imaging is implemented according to the following steps:

step 1: before EIS detection, the bilateral breasts are regionally classified by utilizing a standardized positioning and regionalization method.

In this embodiment, the division of the breast surface detection area is performed by using a laser light source to project light grids, as shown in fig. 1, the subject lies flat to expose double breasts, the patient's xiphoid process is selected as a reference point, the sternum is selected as a central axis, and a reference coordinate system is established.

According to the area of the breast on one side, the light source is adjusted to project 3 x 3 light grids on the breast on the left side, the area of each light grid is equivalent to that of the detection electrode, and the total area of the light grids can cover the breast. The adjustment parameters of the light source are recorded.

And further taking the sternum as a central axis, and symmetrically projecting a light source to the right breast according to the adjusted light source parameters of the left breast so as to divide the detection area of the right breast.

Step 2: according to the divided areas of the surface of the breast, the different areas of the breast are inspected one by using a mobile EIS detection probe (handheld type), a series of detection data corresponding to the detection areas are obtained, and the full-breast impedance distribution information of the breast at one side is reconstructed by using the detection data of the different areas.

As shown in fig. 2, after the breast is divided into regions, the divided regions are numbered, the probe is moved in a predetermined order to detect the breast, and when the detection of a certain region is completed, the region number and the detection result are recorded at the same time. And splicing the detection data of the plurality of areas according to the number sequence of the detection areas to form a prototype of the single-side breast whole milk impedance distribution data. As shown in a diagram of fig. 3, it is considered that, due to a probe placement error, overlapping of detection data, partial absence of detection data, and the like may occur at a boundary of a detection region. According to the principle that the tissue electrical impedance distribution characteristics cannot be mutated, the data at the junction of the regions are restored by adopting a data fitting mode, and the reconstruction of the full-breast impedance distribution data of the unilateral breast is completed. The gray scale map before and after data processing is shown in the B diagram of fig. 3.

And step 3: and (4) carrying out symmetry characteristic analysis on the bilateral breasts by combining the region positioning information and the whole breast impedance distribution information.

After reconstruction of bilateral breast full-breast electrical impedance data is completed by using breast EIS detection data, analysis of bilateral breast symmetry characteristics can be performed, and a flow chart is shown in FIG. 4. The method comprises the following steps:

the method comprises the steps of standardizing and distinguishing breasts, reconstructing EIS whole milk impedance distribution information by using multi-region EIS detection data, and performing bilateral breast symmetry analysis by using the whole milk impedance distribution information to provide auxiliary diagnosis information for EIS;

a "suspicious region" search was performed on the whole milk impedance distribution data at a unilateral breast:

and if the suspicious region exists, carrying out similarity measurement on the electrical impedance parameters of the suspicious region and the symmetric region thereof to obtain a similarity evaluation parameter, and then outputting the auxiliary information.

And if no suspicious region exists, symmetrically dividing the whole-breast impedance measurement data corresponding to the bilateral breasts into N multiplied by N data sub-regions, and carrying out similarity measurement on the electrical impedance parameters in the symmetrical regions. And obtaining a similarity evaluation parameter, and then outputting the auxiliary information.

In this embodiment, whether or not there is a suspicious region is determined based on the presence or absence of a "bright blob" in the EIS grayscale image. First, gray imaging is performed on the whole milk impedance distribution data according to an EIS gray mapping imaging method, as shown in fig. 5, a whole milk image of left and right breasts is shown, and a highlight region is an A, B, C, D, E region. From the position coordinates of the suspicious region, its corresponding symmetry region can be determined at the contralateral breast.

The mean of the measured data in the a region was significantly greater than that of the measured data in the opposite region, with a difference of 16.7%. B. C, D, E areas and the areas opposite to the areas have average difference of less than 7%; thus, it was confirmed that the A region was highly likely to be diseased, and was then confirmed to be a breast cancer region.

According to the flowchart of fig. 4, if no suspicious region is searched, the impedance data of the breasts can be symmetrically divided into N × N regions, the similarity measurement of the impedance parameters is performed on the corresponding regions, and the estimation and the judgment of the health state of the breasts are performed by calculating the similarity measurement parameters.

Although in the present embodiment, the suspicious region is found by the first suspicious region search. However, in order to illustrate the implementation method of the similarity measurement of the symmetric regions involved in step 3, the data of the embodiment is still used for analysis. First, the impedance data of the double milk is divided into 3 × 3 regions by region, and the babbit distance parameter is used as a symmetry characteristic analysis index.

(1) And (6) mapping data. The data of the symmetric regions of the double breast, namely ML (m, n) and MR (m, n), are firstly normalized to amplify the difference, and meanwhile, the measured values can be mapped onto integers for facilitating the subsequent processing.

Min＝MIN{ML_i(m,n),MR_i(m,n)}

Max＝MAX{ML_i(m,n),MR_i(m,n)}

GL_i(m,n)＝ML_i(m,n)/(Max-Min)×100

GR_i(m,n)＝MR_i(m,n)/(Max-Min)×100

(2) Calculating the Papanicolaou distance

As shown in fig. 6, first, statistical analysis is performed on two matrices GL (m, n) and GR (m, n) corresponding to symmetric regions of double milk through a histogram, so as to obtain corresponding discrete probability distributions p (x) and q (x), and the barbituric distances of p (x) and q (x) are calculated according to the following formulas, so as to obtain barbituric distance parameters corresponding to 9 symmetric regions respectively.

From the above calculated barbituric distance data of the symmetric region, it can be seen that the barbituric distance of the region 1 on the left breast from the symmetric region thereof is the smallest, and the probability of lesion of the region 1 is high. It follows that by selecting a suitable threshold, the babbitt distance parameter can be used as a parameter for lesion estimation.

Claims

1. a double breast symmetry detection method of breast electrical impedance scanning imaging, is characterized in that, comprises the following steps:

Step 1: Before the EIS detection, use the standardized positioning and area division method to divide the area of the bilateral breasts. The implementation method is as follows:

(1) The subject lays down to expose both breasts, selects the xiphoid process as the reference point, and the sternum as the central axis to establish a reference coordinate system;

(2) According to the size of the unilateral breast, adjust the light source to project N×N light grids on the breast, the area of a single light grid is equal to the area of the detection electrode, the total area of the light grid can cover the breast, and the adjustment parameters of the light source are recorded;

(3) Taking the xiphoid process as the reference point and the sternum as the central axis, according to the light source parameters adjusted in step (2), project it symmetrically to the other side of the breast, so as to realize the division of the detection area of the other side of the breast ;

Step 2: According to the area divided by the breast surface, use the mobile EIS detection probe to complete the inspection of different areas of the breast one by one, and obtain a series of detection data corresponding to the detection area, and use the detection data of different areas to reconstruct the whole breast impedance distribution of the unilateral breast. information, the specific implementation method is:

(1) Establish a number for the area divided by the breast, and specify the detection sequence of the probe;

(2) The detection is carried out according to the established order, and when the detection of a certain area is completed, the area number and the detection result are recorded at the same time;

(3) splicing the detection data of a plurality of regions according to the number sequence of the detection regions, performing fitting processing on the data at the junction of the detection regions, and reconstructing the whole breast impedance distribution data of the unilateral breast according to this method;

Step 3: Combine the regional positioning information and the whole breast impedance distribution information to analyze the symmetry characteristics of the bilateral breasts. The specific implementation method is as follows:

(1) Carry out a suspicious area search on the unilateral breast whole breast impedance distribution information data to determine whether there is a suspicious area;

(2) If the suspicious area A is found in the unilateral breast, further according to its position coordinate information, determine that the symmetry area A of the contralateral breast is _symmetrical , and measure the similarity of the electrical impedance parameter distribution characteristics of the area A and the area A _symmetrical ;

(3) If no suspicious area is found, symmetrically divide the impedance data of both breasts into N×N areas, and measure the similarity of the impedance parameters in the corresponding areas. By calculating the similarity measurement parameters, the health status of the breasts Make an estimation judgment.

2 . The method according to claim 1 , wherein the method for measuring the similarity of impedance parameters in the corresponding area is to perform a difference analysis on the overall level characteristics of the impedance parameters in the area; or to analyze the impedance in the area. 3 . The distribution characteristics of the parameters are analyzed for similarity.